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MANUFACTURING CHEMISTS ASSOCIATION
1825 CONNECTICUT AVENUE, N.W. WASHINGTON, D.C. 20009 (202) 483-6126
: November 11, 1975
i
To: Technical ,^anel on 'Vinyl Chloride Research
Subject: Meeting on December 11, 1975, 9:00 a.m. at MCA Headquarters, Washington, D.C., Room #407
Gentlemen:
Enclosed is the tentative agenda for the subject meeting. Please note, you will be asked to vote on the question of granting permission to IBT to publish their results in accord with the letter from Dr. Keplinger I forwareded to you October 21.
It has been called to my attention that section 12 of the minutes of the last meeting, which deals with division of effort between MCA and SPI, is intended to relate only to administration and support of scientific studies and was not meant to apply to direct liaison with regulatory agencies.
Sincerely,
MF/m j Enclosure (1)
Milton Preifeld Project Manager
see
5-0251
/.
MANUFACTURING CHEMISTS ASSOCIATION
1825 CONNECTICUT AVENUE, N.W. WASHINGTON, D.C. 20009 (202) 483-6126
November 26, 1975
To: Technical -Panel on Vinyl Chloride Research
Subject: Information Items
Gentlemen:
Please add the following items to your tentative agenda for the December 11 meeting:
5.2 Vote on acceptance of Industrial BIO-TEST's (IBT) September 23 report distributed September 30.
5.3 Vote on IBT request for $20,000 reimbursement.
6.1 Vote on acceptance of final report on metabolism from Dow.
Enclosed for your information are the following:
a. Most recent version,(November 12, 1975) of NIOSH Table I "Reported Cases of Angiosarcoma of the Liver Among Vinyl Chloride Polymerization Workers."
b. Selected parts of pre-publication copy of EPA report on "Dynamic Behavior of Vinyl Chloride in Aquatic Ecosystems" only title page, abstract, contents, conclusion and recommen dations. Sincerely
MF/m j Enclosures
Milton Freifeld Project Manager
nyl Chloride Research
see
5-0252
TABLE X
REPORTED CASES OF ANGIOSARCOMA OF THE LIVER AMONG VINYL CHLORIDE POLYMERIZATION WORKERS
KIOSK November 12, 1975
COUNTRY
CASE //
Canada Canada Canada Canada Canada
Ca nada Canada Canada Canada Canada Czechoslovakia Czechoslovakia Fed. Rep. Germany Fed. Rep. Germany Fed. Rep. Germany Fed. Rep. Germany Fed. Rep. Germany France France France Great: Britain Great Britain Italy Italy Norway Sweden
01* 02*
03* 04* 05* 06* 07* 08
09 10 01* 02* 01* 02* 04 05* 06* 01* C2 03* 01* C3 02* 03* 01*
or*
BIRTH DATE
1st VC or PVC EXPOSURE
AWAITING DETAILS
AWAITING DETAILS
AWAITING DETAILS
AWAITING DETAILS
AWAITING DETAILS
AWAITING DETAILS
AWAITING DETAILS
AWAITING DETAILS
AWAITING DETAILS
AWAITING DETAILS
00-00-28
00-00-57
00-00-26
00-00-51
07-26-31
30-14-57
06-24-30
10-01-57
09-04-30
04-16-57
04-28-25
02-00-57
01-01-32
07-26-62
04-15-24
01-00-46
06-03-11
07-06-59
CG-00-19
00-00-46
00-00-01
00-00-46
05-02-37
02-00-66
11-13-29
00-00-57
03-14-20
00-00-53
12-23-15
03-00-50
06-23-27
08-14-51
DX ANGIO SARCOMA
00-00-73 00-00-66 09-25-70 09-19-68 00-00-74 07-00-74 00-00-75 02-18-67 01-08-75 01-00-75 12-00-72 00-00-74 12-13-72 07-10-75 12-20-71 02-00-70
AGE AT DX
46 40 40 38 44 49 43 43 63 55 71 37 43 55 56 43
YRS 1st EXP TO DX
TOT YRS EXP
DATE OF DEATH
16 15 13 11 17 17 13 21 15 29 26 9
15 22 22 19
16 00-00-74 15 00-00-66 12 12-14-71 11 01-25-69 11 11-25-74 12. ALIVE
12 01-09-75 19 02-19-67 12 01-24-75 29 ALIVE 20 1 ()>' -7 2 4 1 1-74-74 6 12-00-72 21 07-10-75 21 01-04-72
18 10-20-70
see -02^
ir
TABLE I (continued)
REPORTED CASES OF ANGIOSARCOMA OF THE LIVER AMONG VINYL CHLORIDE POLYMERIZATION WORKERS
COUNTRY
United States United States United States United States United States United States United States United States United States United States United States United States United States i.a i ted States United States Un Ltcd States United States Yugoslavia Yugoslavia
CASE it
01* 02* 03* 04* 05* 06* 07* 08* 09* 10* 11* 12* 13* 16* 17* 18* 19 01* 02*
BIRTH DATE
10-17-23 08-19-33 05-25-15 01-15-24 01-25-1.2 00-00-29 05-03-22 05-06-20 11-08-31 08-16-13 05-27-09 11-17-13 12-01-21 11-04-27 05-06-31 04-22-28 00-00-15 04-05-14 11-15-31
1st VC or PVC EXPOSURE
12-09-40 11-15-55 11-28-45 07-06-52 06-19-44 01-17-62 03-00-44 10-07-46 09-09-54 06-12-51 10-14-46 09-13-49 ` 08-19-44 05-08-50 06-23-55 00-00-54 00-00-43 00-00-53 00-00-50
DX ANGIO SARCOMA
03-03-73 05-00-70 12-19-73 08-19-67 04-09-64 02-00-74 00-00-68 08-00-61 03-01-74 05-00-68 03-00-70 05-02-69 05-00-74 00-00-69 10-11-74 00-00-75 06-19-75 04-08-73 07-12-73
AGE AT DX
49 37 58 43 52 45 45 41 43 55 61 50 52 41 43 46 60 59 42
Y RS 1st EXP TO DX
22 14 28 15 20 12 24 15 17 17 23 20 30 17 19 21 32 20 23
Total Reported Cases - 45 Median Values: 17 U.S Ca s c:> 17 Non-U.S. Cases 34 Total Casas
46.0 43.0 45.0
20.0 17.0 18.0
TOT YRS EXP
16 13 28 15 18 12 18 15 17 17 23 15 30 4 19 13 32 20 18
17.0 15.0 16.0
DATE OF DEATH
03-03-73 09-28-71
12-19-73 01-07-63 04-09-64 07-24-75 03-23-68 03-29-61 03-00-75 05-10-66 03-16-70 05-02-69 07-04-74 03-27-69 ALIVE 11-02-75 ALIVE 04-08-73 07-12-73
`
Indicates microscopically confirmed angiosarcoma of the liver. ''00" Indicates unknown <data.
see
5-0254
COPIED BY MCA 11/26/75
c>
DYNAMIC BEHAVIOR OF VINYL CHLORIDE IN' AQUATIC ECOSYSTEMS
by James Kill. IV Heinz Po Kollic Doris F* Paris
N* Lee Wolfe Richard G Zepp
ROAP 04AEM, Tasks 005 and 009 ROAP 03ACO, Task 009
Program Element 1J3A0 2 3
U S. ENVIRONMENTAL PROTECTION AGENCY OFFICE OP RESEARCH AND DEVELOPMENT
KMVLROECENTAL research laboratory
ATHENSt GEORGIA 30601
see
5-0255
ABSTRACT
To evaluate "the behavior of vinyl chloride in aquatic
ecosystems ,
best estimate and worst case taodels of lake and
stream ecosystems were analyzed through
the
use
of
mathematical
simulation*
The
characteristics of the
chemical* bi.ological| and physical transformations of vinyl
chloride.
indicated
in the models were determined by
laboratory experimentation and extrapolation of reaction
data for similar compounds* These transformation's included
oxictation substitution^ elimination* hydrolysis* and free
radical
reactions*
coMplcxatlonJ
direct and indirect
photochemical reactions? microbial degradation and toxicity?
bacterial* algal) and fungal sorption?
and volatilization*
Loss of vinyl chloride from the aquatic environment by
volatilization appeared to be the most significant process
in its distribution*
This report was submitted in fulfillment Tasks 005 and 009, and ROAP 03ACQ, Tack Environmental. Research Laboratory, Athens* was completed as of September 1975*
of ROAP 04AEW, 009, at the
Georgia* Work
ii
see
5-0256
I II III
IV
Conclusions and Recommendations Introduction System Analysis
Assumptions Results and Discussion Chemical Interactions
V
VI
VII I
Materials and Methods Results and Discussion
pH Studies Oxidation Studies Natural Waters Cocploxation
Photochemical Interactions
Materials and Methods Results and Discussion
Direct Photolysis Indirect Photolysis
Microbiological Interactions
Materials and Methods Results and Discussion
Sorption to Microorganisms Bacterial Degradation Toxicity to Bacteria
Physical Interactions
Materials and Methods Results and Discussion
VIII
References
iii
1
3
7
9 16
.33
34 36
36 36 38 38 41
43 44 .
44 45
48
48 SI
51 52 53
54
55 55
Q
see
5-0257
SECTION I CONCLUSIONS AND RECOMMENDATIONS
A worst case oystea analysis of vinyl- chloride behavior in aquatic systems 9Uf;!?csta that unrealistically high levels ol vinyl chloride inputs would ' be necessary to maintain significant concentrations in these systems* However* given extreme environmental conditions* aquatic sediments could exhibit long--torn storage of lour levels of vinyl chloride*
Chemical degradation of vinyl chloride under pH's*
reactant concentrations*
environment
should not
oxidation nor degradation
and temperatures common to the
bo significant*
Neither auto-
by free radicals is important in
most natural waters at low vinyl chloride concentrations*
Increased persistence of vinyl chloride due to coaplcxation with Ag+ and Cu4- should be minimal* Data are not available
for consideration of other metal species*
Experiments with distilled water* water from the efflu ent of a PVC plant* aiid two natural waters indicate that photolysis of vinyl chloride is probably a slow process under envircnvien'cal conditions*
Vinyl
chloride
docs not appear to be sorbed by
microorganisms * as indicated by laborctory experiments with
five
raided
bacterial populations*
three mixed fungal
populations* tvro axenic bacterial cultures* and one alga*
The five islxod bacterial populations did not degrade the
vinyl chloride tc any detectable extent*
Also* at vinyl
chloride concentrations up to 900 rag 1"~1 no toxic effects
on the bacterial cultures could be detected*
The rate of bulk exchange of caseous vinyl chloride bet ween atmosphere and water* is about twice that of oxygen* Loss of vinyl chloride by volatilization from water is therefore probably the moot significant process in its dlstribution *
Ih`o assumptions and coafcocruently the conclusions of this analysis may be invalid when vinyl chloride enters a re ceiving water no a component of a tar or sludge or when large concentrations of surface active agents are present with the vinyl clilori.de in water* Further study is neces sary for specific situations where these conditions exist*
1
see
5 - O 2 c< 8
The reactions of vinyl chloride with chlorine and hypochlorous acid should bo studied under conditions that pre vail in tho chlorination processes of municipal water treat ment plants Also, the reactions of orpanlcs that may form vinyl chloride under these conditions should be studied
COPIED BY MCA *'11/26/75
2
see
5-0259
Manufacturing Chemists Association Technical Panel on Vinyl Chloride Research
9:00 a.m.
MCA Headquarters, Room #404 Washington, D. C.
December 11# 1975
Tentative Agenda
1. Minutes of Last Meeting
2. Financial Status
(Freifeld)
3. Selection of Vice Chairman
4. Review of Epidemiological Studies 4.1 TCA 4.2 Other Studies
(Torkelson)
5. Review of Industrial BIO-TESTStudies 5.1 Vote on Request for Permission to Publish Results
6. Review of Dow Studies
7. Review of Responses to Questionnaire on PVC Dust
(Freifeld)
8. Revision of SDS
9. University of Louisville Proposal
10. Future Meetings
(Dr. Tamburro)
11. Next Meeting
see
5-0260