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CONFIDENTIAL World Register of Cases of ANGIOSARCOMA OF THE LIVER (ASL) due to VCM j REVIEW DATE 1st JANUARY 1989 :4kbr - n. marim Bamatt Occupational Health ICI Chemical* and Polymars Ltd Hillhouaa Site PO Box 4 Thomton-Clarolays Blackpool FV5 4BD England CTOlaphon* miox Facsiml1* cm* 01015? CSSS BB1B3B 1 474*3 ICIFUm 0299 BB1BB1 / liver angiosarcoma cases CIRCULATION OF REGISTER CONFIDENTIAL FEBRUARY L9S9 APPLETON B BAGSHAW Dr I M M BAND Dr P R BARON Dr C BARRAT Dr G BAXTER Dr Peter BAYLAC Dr BELLEC Dr BENECH Dr M BENNETT Dr B BERTAZZI Dr P BERTUZZI M BEYNON D W S BISHOP Dr C BORRELLI F E BRAUN Dr C L J BREWER Dr M D BRYSON Dr D D BYREN Dr David CARTER Dr J T CATANZARITI A CELLA C CHANCE M CLARKE Dr E A CLAYTON H CONTASSOT Dr J C DAVIES J G DE JONG Dr G DELORME Dr F DEPLAN Dr F DIETZ Dr H W DOLL Prof Sir Richard DOMBROWSKI S L S DRUMWRIGHT Dr J R DUPONT G EMMINGER H ERNST Dr W EVANS Dr A E J FALK, Dr H FAVRE Dr FIELDING Miss C FILLINGER J FINCHAM Ms Shirley FOA Prof V FORMAN Dr_D FRASE R W FREIESLEBEN Dr W FRIEDEL Dr H P GAFFEY Dr W GOTTESMAN R T GROISMAN D HILUiAN Dr D W HOWARD Dr J K HUMPHRY Dr N F ICI Runcorn, UK Hydro Polymers Ltd, Newton Aycliffe, UK Cancer Control Agency of British Columbia, Vancouver, Canada ICI Runcorn, UK AECRP, Commentry, France University of Cambridge, UK Atochem, Chauny, France Rhone Poulenc, Aubervillers, France Naphtachimie, Lavera, France ICI Hillhouse, UK Inst of Occupational Health, Milan University, Italy EVC, Brussels, Belgium ICI Runcorn, UK EMAS, Cardiff, UK Georgia Gulf, Delaware City, USA Akzo, Arnhem, The Netherlands Imperial Oil, Sarnia, Ontario, Canada ICI Wilton, UK Nobel Industrier, Sundsvall, Sweden EMAS, London, UK EVC, Brussels, Belgium EVC, Brussels, Belgium ICI Runcorn, UK Ontario Cancer Foundation, Toronto, Canada Norsk Hydro, Newton Aycliffe, UK Atochem, Saint-Fons, France EVC, Brussels, Belgium Shell, An Den Haag, Holland Quebec, Canada Atochem, Jarrie, France B F Goodrich, Akron, Ohio, USA Imperial Cancer Research Fund, Oxford University, UK Dow Chemical, Midland, Michigan, USA Vista Chemical, Houston, Texas, USA APME, Brussels, Belgium VKE, Frankfurt, Germany Berufsgenossenschaft der Chemischen Industries, Nurnberg, Germany Lever Bros, Warrington, UK Centres for Disease Control, Atlanta, Georgia, USA Atochem, Montluel, France ICI Millbank, London, UK Solvay, Brussels, Belgium Alberta Cancer Board, Edmonton, Canada Inst Industrial Medicine, Milan, Italy Imperial Cancer Research Fund, Oxford University, UK DiversiTech General, Akron, Ohio, USA ECVM, Brussels, Belgium Berufsgenossenschaft der Chemischen Industries, Heidelberg, Germany Monaanto Co, St Louis, Missouri, USA The Vinyl Institute, Wayne, NJ, USA Electrochemical Industries, Acre, Israel Diamond Shamrock Corp, Dallas, Texas, USA University of Otago School of Medicine, Wellington, New Zealand ICI Australia, Melbourne, Australia o WPX/ASL - ASL ADDRESS,! O O JOHNSON Dr C A JOHNSON Roy N KAIPERT Dr J H KLEIN Dr H LAGAST Dr H LANHAM Dr John LANOUZIERE Dr Claudine LAWRENCE-JONES Sir C LEE Dr F I LELBACH Prof Dr WK LEVEQUE Dr G LEVISON Prof Dr D A LEWIS Dr P LIGO Dr R N LO MARTIRE Prof N LUSS R D LUSSATO Dr Josette MALTONI Prof C MATTIUSSI Dr R MELTON B MIDDLETON D MOKKA Mr MONTESANO Dr R MOTTI Dr A A MUNOZ MOUTON Dr M MacSWEEN Prof RNM NAKAMURA Dr S OSMAN Dr J PADDLE Dr G M PAGLIALUNGA Dr S PAQUET Dr Christiane PATERSON Dr J C PIRASTU Dr Roberta POSSBERG Dr J PUECH Dr A M PURDHAM Dr J RAMBADD Dr J RICHARD Dr A ROBSON Mrs D RODRIGUES Dr MJF RUTY Dr J SALG Dr Joyce A SCHIPPER Dr H SCHUCKMANN Dr F SERONNE Dr D SHAH Dr Has SIGRIST Dr- J SIMONATO Dr L SMITH Prof Allan H SMITH J S SMITH Dr P M SPIRTAS Dr R STAFFORD Dr J STAHNECKER Dr E SULAIMAN Dr -2- Goodyear Tire 4 Rubber, Akron, Ohio, USA GenCorp, Fairlavm, Ohio, USA Dow Chemical Europe, Horgen, Switzerland Dynamic Nobel, Troisdorf, Germany Solvay, Brussels, Belgium Dow Chemical, Midland, Michigan, USA Solvay, Tavaux, France Chief Medical Officer, ICI, London, UK Victoria Hospital, Blackpool, Lancs, UK University of Bonn, West Germany CDF Chimie, AZF, Bully-les-Mines, France Guy's Hospital, London, UK Chemical Industries Association, London, UK Dupont, Wilmington, Delaware, USA EniChem, Milan, Italy Occidental Chemical, Pottstown, Pennsylvania, USA Atochem, Port de Bouc, France Institute di Oncologia, Bologna, Italy Montedison, Milan, Italy Formosa Plastics, Delaware City, USA Hydro Polymers Ltd, Newton Aycliffe, UK Neste Oy, Espoo, Finland 1ARC, Lyon, France Duperial SAIC, Buenos Aires, Argentina Rio Rodano, Madrid, Spain Western Infirmary, Glasgow, Scotland Japanese PVC Association, Tokyo Health 4 Safety Executive, Bootle, UK ICI Central Medical Group, Alderley Park, UK Montedison, Novara, Italy Atochem, Serquigny, France ICI Runcorn, UK Istituto Superlore di Sanita, Rome, Italy Wacker-Chemie, Munich, Germany Atochem, Brlgnoud, France University of Toronto, Ontario, Canada RP Racherches, Antony, France Rhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada ICI, Sao Paulo, Brazil Atochem, St Auban, France NIOSH, Cincinnati, Ohio, USA University of Manitoba, Winnipeg, Canada Hoechst, Frankfurt, Germany Diamond Shamrock, Dallas, USA CMA, Washington DC, USA Shell Chimie, Berre L'Etang, France IARC, Lyon, France University of California, Berkeley, USA ICI Hillhouse, UK Llandough Hospital, Penarth, UK NCI/NIH, Bethesda, Maryland, USA Somerset, UK BASF, Ludwigshafen, Germany Arabian Petrochemical Co, Saudi Arabia CMA 10Ul WPX/ASL - ASL ADDRESS,2 -3- TACHECI Dr H TAMBURRO Prof CH ten 8ERGE Dr W F TENKHOFF Dr N TEPPER Dr L B TERWIESCH Dr B THERIAULT Dr Gilles THIIS-EVENSEN Dr E THOMSON Dr D H TONER H ? VAN DER MERWE Dr H J WALLACE J R WALTEMATE H WEJDLING S 0 WILLIAMS Dr DMJ WILSON Prof R YORK J YOUNG A ZOBER Dr M A Hoechst AG, Frankfurt, Germany University of Louisville, Kentucky, USA DSM, Geleen, The Netherlands Huls AG, Marl, Germany Air Products, Allentown, Pennsylvania, USA Huls AG, Marl, Germany McGill University, Montreal, Canada Norsk Hydro, Porsgrunn, Norway Cancer Treatment & Research Foundation, Halifax, NS, Canada Society of the Plastics Industry, Washington DC, USA AECI, Sasolburg, South Africa Esso, Sarnia, Ontario, Canada BF Goodrich, Cleveland, Ohio, USA Norsk Hydro, Stenungsund, Sweden BP Chemicals International, Barry, UK Harvard University, Cambridge, Massachusetts, USA EVC, Brussels, Belgium EVC, Brussels, Belgium BASF, Ludwigshafen, Germany From: Dr B Bennett, Occupational Health Department, ICI Chemicals & Polymers, Hillhouse Site, PO Box 4, Thornton-Cleveleys, Blackpool FY5 4QD, England WPX/ASL - ASL ADDRESS,3 CMA 010162  9 1 0 1 0 VWO CONFTD" 07 '1 TT L REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 1989 PREFACE : ACKNOWLEDGMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS 1 The 7 new cases in the Register ere the following: Canada 13; France 23f 24 and 25; Italy 07; UK 15 and 16. 2 There are amendments froa the yrev&ous Register against the following cases: Canada 11 and 12, UK 14 and US 41. 3 I would like to thank the following for information about new cases: Dr Dietz, Dr Contasaot, Dr L&gast, Dr Benetta, Dr Williams, Dr Smith, Dr Lee. 4 For additional information about other cases I thank also Dr Delorme, Monsieur Bibeau, Dr C A Johnson, Mr Roy N Johnson and Professor Lelbach. 5 So far as I know the following people are still alive: cases France 15, 22, 23 and 24; Germany 31 and 32; US 33 and 36. Is this correct? This is important information for the industry world-wide and I would appreciate news, especially regarding the cases in Germany, please. 6 Tables 40 and 4h have been enlarged by the addition of the factories at Tavaux (France) and Hillhouse (UK), as each of these has now had 4 oases. 7 I ahnnTA be glad if all recipients of this Register would continue to keep me fully informed of any new cases, or give the "*" and address of someone who can send me the necessary details. 1 have again attached a blank she t at th back of the Register so that information can be supplied under the appropriate headings, so far as possible. Please also send any other relevant information about earlier cases, or about factory changes. 8 RESEARCH: (a) May I again ask that all individuals involved in relevant research keep me informed and if possible send me reports. Perhaps recipients of this Register would pass on my request. (b) Co-factors - I have recently met Professor Carlo Tamburro at the University of Louisville, USA, to assess the data which many of you kindly sent in response to my questionnaire about possible co-factors with Vinyl Chloride. We found there was no correlation within Europe but among the North American cases there was a suggestion of a co-factor effect on latency. In plants where Di-Ethyl Maleate had been used, the latency period seemed to have been shortened. 9 There was an excellent response to the circular I sent in June 1988 about the Register mailing list. Please continue to keep me up to date with news of retirements, movements and changes of address. Thank you. FROM: Dr Brian B nnett. Occupational Health, ICI Chemicals &`Polymers Limited Hillhouse Site, P O Box 4, Thornton-Clev 1 ys, Blackpool, FY5 4QD, England February 19&9 BB/BGS 1 ICI CHEMICALS & POLYMERS UPX/ASO - LANGIOCASES,A Index Table Sequence Belgium 1 Canada Czechoslovakia France Germany Italy Japan Norway Sweden UK USA Yugoslavia Incidence of Cases per annum (Table 1) Distribution of Cases by Country (Table 2) Pattern of Cases by Factory (Table 3) L tency Periods (Table 4A) Distribution of Latency Periods (Tables 4B-4H) Annual Geographical Incidence (Table 5) LIVER ANGIOSARCOMA CASES (REVIEW DATE - 1 JANUARY 1989) \ 1 Page 1 1 1 1 ASL Case Numbers by year of Death ( (Table 6) 2-3 1 l ASL Case Numbers by year of first exposure 41 (Table 7) I 5-9 1 Western Europe PVC Producers - Start-up Dates vs ASL Cases 1 (Table 8) 10-15 1 1 USA PVC Producers - Start-up Dates vs ASL Cases 16-17 1 (Table 9) I 18 1 Canadian PVC Producers - Start-up Dates vs ASL Cases t (Table 10) 19 t East European PVC Producers - Start-up Dates vs ASL Cases 20 t (Table 11) 1 21-24 1 Japanese PVC Producers - Start-up Dates vs ASL Cases 1 (Table 12) 25-32 1 1 South & Central American PVC Producers - Start-Up Dates 33 1 (Table 13) 1 34 1 Australasian PVC Producers - Start-up Dates 1 (Table 14) 1 35 1 Middle Eastern PVC Producers - Start-up Dates 1 (Table 15) \ 36 t Blank form for notifying new cases 1 | 37 1 1 38-44 1 1 1 l 45 ! 1 1 Page 46 47 48-49 50-51 52 53 54 55 56 57 - CMA 0 1 0 1 M Page MLCUM IC1 CHEMICALS A POLYMERS LIVER AnglMircoiu Caaei - (Review Oate : t January 1949) WPX/ASL - LAHOlLtCASES , b COUNTRY AMD reference NAME OR INITIALS DATE OR liTU 01 12.01.11 Solvay 02 29 09 AO Solvay FACTOR! FIRST VC 00.07. 5t DATE OF DIAGNOSIS 00.05.76 ACE AT DIAGNOSIS YEARS OF EEROSURE TO DIAGNOSIS 1ft YEARS Of EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OLLUPAriON High Autoc I eane r IA yia 1958-1966 exposed Co Poly worker 200 pp* ) yra tor 6 hra per day and certainly 500 pja In 6 Co *.) autoclaves iltt-iiJi eapoaed Co 50-200 ppm t hra per day In 25o* autoclaves n72-i*7i eapoaed to 50-200 ppa In auto clave roota 1974-100 PP* 1975- 50 PP RETIRED I feb 1975 uVhek | ilTHEK CAREER | aJttHEMfb HIGHLIGHTS _Jl____________ I l Driller In a (Heput It r ee * v foundry || Oil 19/4 <2 yra) |we re iiurne i - tiracr |Rei lied ( 15 yra) | Feb I* ? S Work In glasi |Huflpltelised Ind. A rhenl- lHey | 976 Ical Industry (Cunplet e iCUnltal and (career dec alls |are given lit Ipaper by I Hub I el ei at fin Arch. Relg . (Med. Sue., lyg. Med. |Trv. Med. i Leg. 1197 7 page* J6UI-622 li l I J*Wa 00.10.79 17 06.62-0 j. 61 01.67 -III.71 * 200 pp*t Rh/day 04,61-12. 66 4 200 pp Autucleaner 5 yru 5 nth# Operator } yia 9atha. FI rnuifl 10 71. wince Jlar algit Inly |79. Ihut di 1. |pain 0 f,If, |Heput It l ^ I a 11 e i *<i ii>. ;y. (Pov11 1 ve leihogr aphy 111.79. K-ij (tet 1 mj ItS . rt>t. (4 lirs<;i l<r ,4|.y . 1..l..J..-.n.m..a.i 1 uo | 1 l-l I < I I N-.* k IVOh I i ..at Ut J Ik SI ..* i . CMA 0 1 0 1 6 5 Nde 2 CANADA Sheet I I Cl CHEMICALS * POLYMERS LIVES Aagtoaarcoaa Ceeee - (Review Dele: 1 Jen 1969) DAY - MONTH - YEAR All"Jelei uee UK aywten UPXSASL - LAHGlOCASfcb^ COUNTRY AND reference NO INITIALS DATS Of Dim 15.12.13 02 06.03.14 03 24.09.19 05.04.19 07.05.11 COMPANY FACTORY SHAHIN1CAN run vc 1944 1943 1941 1945 1944 DATS Of DIAGNOSIS 1455 1931 1942 196V I960 ACE AT DIAGNOSIS 41 49 57 YEARS Of EXPOSURE TO DIAGNOSIS 22 24 YEARS OP EXPOSURE DATE OF DEATH 14 21.12.57 20 23.03.62 05.07.4 12 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION 15 \ OTHER CAREER HIGHLIGHTS I | | | OTHER CUMMEN lb I I Reactor Operator ( (Saoker cleaner polyaerlaat Lon| I I Maintenance, Operator {Worked I IIwrlghi, pipe!I it cr (overt Ik iSaoker I_______ I Operator, (Worked 1 oreaan lover t lee |Nan-satAr I I Reactor Operator. | Worked clcane r lorcarn, (overt lae water cooling jSaoket unit 1 __________________ I___________ Reactor cleaner Water coo Ilag (Worked on It (overt In (Saoker 15.12.19 1947 1971 10.04.71 Reactor cleaner HaInt enance, aJilwrlglil 1 (Worked /over! lae (Saoker 09.11.19 1.05.20 19.07.21 1946 1961 1 25 React or Machine a hop (Worked rleaner operator and invert(a poly unit |Saw>ket __ 1_________ I Kt-ai l or iLeaner Halnreiiaiue aclilne shop I I'1 P*'"11 (25 yrvl I__________ tornare op. plpe-llller (Worked InvertIm Jbaokc i I________ * Paper by Dr DELURHh In Annalea d'Anatoale pathologl^ue Pari a. (976 Vol 23 No 2 ppl05-ll4 clalaa thia rate had both a hepatoaa and ASL b Inal t aneuua ly. 9 9 T 0 T 0 VW3 Page CANADA Stoeat 2 I Cl CHEMICALS 4 POLYMERS LIVER An|lMarcou Cases - (Review Date; I Jen 1969) PA - MONTH - YEAR All dates use UK ayiu WPX/A5L - LANLIOCASES.B COUNTRY AND MIEUNC1 HAW OR INITIALS un or NINTH COMPANT | RACTOn RINNT VC | OATS OP | OIACMOS1S I J_________ ACC AT DIAGNOSIS TEARS OP EXPOSURE TO R1ACHOSIS YEARS or EXPOSURE DATE OR MATH HISTOLOGICAL C0NPJRHAT10N ESTIMATED EXPOSURE LEVEL OCCUPATION n OTHER CAREER HIGHLIGHTS OTHER COMMENTS (14.05.15 11 LC in. 10.25 | Gulf 114.09.20 | Cull 11 110.04.24 | NEC 1953 1974 mi Nov 85 AO 14 100*04.17 (0i.04.NA 3?1945 Mar 12 Al V I3I.01.N2 19)7 1987 40 23 124.1.8) (Furnace op, alntenance, (packaging J High | 1943-47 (Operator 4 (Supervisor |VC Plant j l ni i J 19;; I (Me iederv hua i)t lentand Delores, Pal ho lug lac a H 81 beau. Utr. High I1945-55 (Autoc lave (Operator, iPVC Reatna 1 |1455-45 |VC (Manufacture (Retired 1972 ((Age 52) (Letters trua |Dr Fernand |Deloree (Pathologist a JH At beau, ftlL I 1 1 1957-10 High 1970-80 Low 1(965-72 I | Autoclave I (Operator. 1 |PVC Rea low _L 1( |Poly Cleaner |Retired 1980 (Jntoruation |4 Operator |(Ae 54) 11 run 1 l Dr K W (itetr. (Supervlaur |*1L. IVOB CMA 0 1 0 1 6 7 r * CZICNOSLOVMIA ICI CHEMICALS 4 POLYMERS | LIVER ta|iM*rcou Ceeee - (Review Date: I Jen 09) WX/ftSL - LAWGIOLASLS, * s > * 10 COUNTRY AMO HAHE 01 IMITCAU DATE Of 01R1H COMPANY FACTORY ruor VC hate or DIAGNOSIS ACE AT DIAGNOSIS TEARS Of EXPOSURE TO DIAGNOSIS TEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTMtK COHHLNTS OCCHOSUh tarIU 01 20.06.2* State Co NovaRy 01,07.5? 24.12.73 45 14 14 24.12.73 Autoc Lev Cleaner IARC letter of 1-4-S2 gluing detel|i It<m Fiot A David af Centre ld Hygiene end Occ dleeeee*. 02 04.07.27 State Co 01.11.50 27.11.44 37 14 15 24.11.64 l Autoclave Cleener I ARC letter of 1-4-B2 gave eoaewhet eleered detee fur tble ceee. I Neve [accepted the [change* aluce |lhe datea coae If row Prof [A David of the [Centre of | Induet rial [Hygiene and |Occupet tonal |DI*ea*ea, Hy [detee come [originally [froa N10SH. o vwo Page 5 FIANCE Sheet I ICl CHEMICALS A POLYMERS LIVER AAgloearcotu Caaea - (Review Date: I Jen 19) 10 12 1) WX/AbL - LANClOtASLS,LU COUNTRY AMO MAM 01 DATE OF tereuMci INITIALS urai COM!AMY l n*fr *c ractor* I a^ttVM DATE OF DIAGNOSIS AGE At DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER CUMMENfb PRANCE 01 02 1 | *H | | | 1 i i |S1H 1 11 11 111.06.24 1 RP 11 11 11 1t 1| i1 101.06.11 1 reux 11 i i 1 (lOdAI* 1 HIM 1 I 1 1 1 llrliWMl 1 Ii ti 1 I 00.01.44 i ii 1i |i ii ii i | 04.07.39 1i 11.02.61 13.01.73 i i | i i i i i ( i i i 43 43 i t i i i i 21 14 1 tt 1 ii | || i 19 II*.02.67 | i 1| 1 1| i i| 1 11 Yea i1 11 1 1 High (Autoclave (worker and |cleaner 1 II* yr. 1 i _it 1 11 1 12 124.01.71 | _j___ 1 11 Yea 1 High |2 yre on Italian 1 1 1 (NIOSH no leunoaer origin 10 yn on polymer- ieatloo 1 1 |Ret. Mauler ec |al Arch. Mat. (Prof. 1 JO ' |3 Nov 75 ip 171-171 1 i (Ret. |C Runnelon et al "NuuvelL preaae erftcale" 5 Nov 19/; p n*> 03 04.01*10 19u Rom 00.00.44 13.01.73 35 29 29.04.73 High Polyworker 10 yr* aa autoclave cleaner Compounding 3 yra VCM production Ret. Rely cl lb y al Ait h. Hat. Italian PON Pro!. I 1/ u' Shepherd. 6 June it Sawyer. Haaon p 5W-iSi 05 O > O H* O K o 27.01.27 PCtIK 29.01.3f ItlfMul | 19.10.49 1 I I I I 14.01.74 IrlgMud | 14.01.45 13.05.74 24 24 04.01.74 Ye High Monomer product ton worker A yra rvc flit rat Ion IB yra II High KoIy Murk er I)Thuracoloay U yra 9th Feb 1976 el aJ 'Si-kjl.tv coetal de& lu>b pit aim angloaarcoaa ID bepteubre 7>SclntIgraphy J9/6 found ASL fievlttubly |aj 1)Haemorrhage tune frue ASL 4>Rlght ailgtubal t .a Also Nepal ei t uay PI 11, IlllHSt I l I a J La N-in+v t I | c 'l cbt Ml' J k. <11c 7lb July IV/V i CMA 0 1 0 1 7 0 Pgfi prance Sheet 2 COUNTRY AMP unuia NAME OR INITIALS DATE 0V Aim COMPANY Pe 14.04.34 PCUR 07 11 2ft.04.27 Oft 01.04.34 Salver 09 SPE ,0ft.10.14 1CI CHEMICALS 4 POLYHERS LIVER AA|loircoM Uau - (Review Date; 1 Jan 1989) UPX/ASL - LANUUCASfcS.lt rAcrorr tJ rim vc DATE Or eucuosis Rrlgeoud 01.03.3ft 12.Oft.74 St 4Im 01.07.30 After ftlOSM *P 00.07.7ft Teveu* 23.03.37 03.12.73 St fa 10.01.4ft 2ft.04.7ft ACE At dughosis 42 49 42 ftl 10 i n YEARS Of J1 I | YEARS OP | DATE OR EXPOSURE TO | EXPOSURE | DEATH DIAGNOSIS | ___________L 1ft | II.09.7ft |(NIOSM |eeye 112.09.74) 2ft 22 102.07.74 j it 19 (30.01.77 2ft 2ft Hi.ii.7t 1 12 13 1 14 t 13 !1 l HISTOLOGICAL ESTIMATED I CONTIRMATION EXPOSURE | OCCUPATION 1 OTHER CAREER LEVEL 1 J 1 I HIGHLIGHTS J 1 1 Yee Node rate 1(1938-1960) 12 yr. (lillrai1on |10-11 yra (polywurker (end worha | lebf l 1 J. Tee (KIOSH no CMMRt) Hlfh 1 J 1 fPleiu tote- 11972-6 adnln |aan In (eectlon In | polyMr- (St Auban (leattoo 1 1 ( 16 .1___________________ 1 ( emit* | COHMLNlb 1 1 1 1 (Title aan had (AOL prior to (AS. Ann. de (Hal. Prut. (July 'il |p 6A5 4 6. (AOL wee found |In (971 five lyre before (ASL ) 1 (Died of laeptIcaeela (Seal 1 liver (lea Ion found (after eulupuy 11 Yee Moderate |4 yra packer! (Had been |4 autoclave (tunnel wuikei |c lor (prevl ouily |U yr ( |autaclave (worker 1 1 ji 1( Yee Very High iPolyeer- ((0 yra In (Operated 4. ft* 1949-1944 | leatlon |aufphurlc |for removal ul Leaser (operator, (acid factory , 11 ueioui 111 Eapoeure lautocleaaer. (atorekeeper 4 lllver and 1944-1976 (autoclave (general Idled atLer (ealcueaaace (eervicee (second 1 jeurglta1 1 (operat(on t .k 1 (blllo 1 IbromliUJ 1 | f 1 atula 1 |Paper by 1 |l)r Reiy n d| 1 | 1n ftithlvea dc 1 |Ha1adeu ( | Pi ot et.i l ..il.* | I IV.. 1 40 Ho t, 1 |19)V pagea l ( 741 - 1. A___________ 1 Page J FRANCE Sheet 3 1C1 CHEMICALS 4 POLYMERS LIVE* AnglourcoM Caaea - (Review Dele: I Jen 1969) 3I* 10 12 WFR/ASL - LANCIflCASES, I 2 COUNTRY AN0 HAW 06 INITIALS DATS or SlftlN COMPANY PACT06T nut vc DATE OP DIAGNOSIS ACE AT, DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION EST(MATEO EXPOSURE LEVEL OCCUPATION OfHLR CAREER HIGHLIGHTS OTHER COMMENTS France u 24,03.19 I5.6i.ii St Pom 00* 12.34 10.01.76 36 St V. tsoot H.TSOr ir TT TOOT pent grlgacW TW.BTTf aa.Tsrrr TT tt.oi.ii Soleay Tavawt TOTtT 14.06.19 Tir 14 MJ 03-04-24 Ctrtoe Ch 1*1 e (ForMarly RP) 1943 00.01.6k 57 tr 10 16 36 10.01.76 TT7TT77T IT TOOT n. tr H.6*;74 36 29.07.61 High High Antuclave cleaoer 10 yra In Mechanical engineer Lng Industry 1946-1936 1511-1946 pok/Mer- laalton general purpane worker 194&-1972 VCH eyntheele (HCI 6 Acetylene) Porenen (agent de nattrlae) T5Ti retired Died of pulaoneiy eaboltau 3 daya after aurgcry High Nonoerr produc cI on and polyner- l>ttIon operetor Autocleaner 7 yri, Auto- 2 yra aa cycle Cigarette echanlc. anoker wot 10 yr* aa (974. Ill operaLor enaneller In ot 197/ J.. 9 yen, Copolymer^ 4 yra aanitary ware Manufacture Oeaoptiagea v*l I t en . Sul gleel 1 til erveiu 1 23.03.79 ( r Lglit l i.ia Very High 1943-1975 1973-1979 1943-1973 All cypea of Maintenance and Juba on work (literal 11 - a itutiiluft ent (y 1973-1979 A wliUeium In Vi.H Koly 1*F Ui ehh CMA 0 1 0 1 7 1 Page FRANCE Sheet 4 1CI CHEMICALS 4 POLYMERS LIVU tailMtcoM Uia - (Review Date; 1 Jen 1989) WPI/ASL - LANClOCASfcS,I J 5|8 10 12 I) COUNTRY AND NAME OR INITIALS DATS or SIBTN raenu nttT vc DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OP YEARS OF exposure to EXPOSURE DIAGNOSIS DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION Prance I) Oi.OI.37 Cfeloe CkUlt ((ofearlf rf) t You 07.07.15 20.09.82 41 27 27 High-20 yr Moderate 7 yr Autoclave cleaner 1911-1962 autoclave operator 1962-1982 OTHER CAREER HIGHLIGHTS OTHER COMMENTS Left Hapai ectony 1983 J C Coniaaaol Letter* of 1 10 1983 and 29 7 88. 8118 13.07.22 Chloe i Pom 17.10.41 01.01.S3 41 03.04.83 Hlgh-33 yra PoJynerlaat Retired Qiiala Moderate- loa Procaea Jan 1979. (Idnwtiy Low - 1 yra J C Contaaaot tr> Letter# of Maintenance 1 10 1983 and Worker 21 7 84. X II 22.02.23 OllM c r 17.08.40 03.04.83 80 Chlale (fQiwcijr > Health 4 Safety Agent X 28 03.04.83 Tee High - Autoclave Other aectora Ret 1red 23 pra Cleaner ot St Fone OJ .01.79 1948-1971 Factory 1971- J C Cootaaao 1978 Letter of 1 10 1983 18 14.07.42 Solvay evaua 09.09.83 21.03.84 42 TO 27.12.84 21.03.84 High-12 yra Autoclave Low - 9 yra Cleaner 09.01.84 Right Hepatertoay Ob.Ob.8424.09.84 cIwautiiet apy lot lungaetaataelu part fat realsalon. 08.84 - llvet reiur rente. 10.84 - Lmi* fvululton ol I lie J1 b eJae to Pge 9 FRANCE Sheet 1 COUNTRY AND icreuHCi FRANCE It "1T MAM DR DATE OF INITIALS ftira JS.J2.12 02.01.21 Fa 01.10.60 COMPANY Acocbem *n.t cOCHli.ALh 6 PULtHtKS LIVER Angiosarcoma Cases - (Review Date: l Jan 1989) FIRST VC UFOSUSf DATE OF DIAGNOSIS II IQ J_ JL ACE AT | YEANS OF f YEANS OF DIAGNOSIS | EIPOSURE TO | KFOSUNE | DIAGNOSIS | i___________ i________ I DATE OF DEATH IclfMN 07.0A.lt 26.1Q.R4 12 21 06.JI.SI ItlgOMl 1911 27.l2.il 63 36 22 26.12.61 SEP Most Iwm TKT ol.oi.it TT IT lt.0i.S6 HISTOLOGICAL CONFIRMATION 16 ESTIMATED EXPOSURE LEVEL High High High OCCUPATION OTHER CAREER HIGHLIGHTS I ( \ I OlHtK CUMMIN IS _L I |Myocardial Autoclave operator and cleaner |Inf sre t ion |1960.Coronaly (bypass 1981. (Letter feu* |Di Contiitut fl.4.66__________ |Port al Aut oclave In other part, i If Ibruala tna operator and of factory 126.04. )6. The alnce 1966 )11kneaa war (diagnosed sa (presumably (work related (on 20.04.24. |Letter fro* |Dr Contaaaol Autoclea 6 years Halnienance worker fU*>. 04.6b (Hepatic teat (Hay 64 nt*c*a L. (Hepatic tear (Hay 66 showed (abnormal It lea. (Letter fro* (Dr Barral ---------- IT" 1 AL in.ot.it 1 Atmehear lit Mm | 6l.OD.5D i 05.11.1? I ii i H-- i li i.tlva | Yea | || 11 1 t i t 11 | || 11 1 1 i 11 ( || 11 1 1 11 I i1 11 1 1 i 1 J1 TT 1 .J_____ _ ____ .---ir- ____ 1---- 1 ..J. TT DO mrir UodM ' iwr T55T TT TT IT *n TT u--ira;i : Solv.jr Tavaua itti w ~2t~ TT 07.05.as 1 High |12 yeara | | 1918- 70 |Auioclave | 1 |worker. | | Low 1 J ( J970-H4 J J4 yeara In J |Control Roum| Cleaner 6 all PVC product Jon Juba High 1! year.) High) J 2 year a) Low ) PVC Production - 2 years HCV Detection - ) years PVC Produi t Ion alot ensuee - )<J years Polycleaner - 1 yeara Poly ILoor - 6 yeara Control Rou* - 12 yeara (Letters from (Dr Contassoi, J Atochem (2.12.62 and |29 1 66. _________ i__________________ JC rairapJ ant (Nay I9SH. | Inf ureal lun ii tJ (Dr J C Coni aetau (At PChem. I9d iPartlal f fiepatectomy , Ap . 166, Cheoiheip (Information t<o |Dl Coitl ( JAtoihe*. ISttft _i |Prlaajy llvti (Tuawit Ht,-U4i..c l i ui<k , buih, |b Line , spleen , | ktdney. I 1 ........................................g. |D tl l , CMA 0 1 0 1 7 3 Page GERMANY I ICl CHEMICALS 4 POLYHERS LIVES Angloearco Uus - (ftevUw Oatr. I Jan 1989) 10 12 JJ UP1MSL - LANC LUCASES , (`i COUNTRY AMD REFERENCE NO HAW OR INITIALS UTt Of NINTH COMPANY | FIRST VC FACTORS | UIOW I I________ DATE Of DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS Of EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATE!* EXPOSURE LEVEL OCCUPATION OTHER CAREEN HIGHLIGHTS OTHER COMMENTS GERMANY 01 i 02 i i i 0) i 1 1 i i t i 1 1 1 I i t i i i i i i 04 1 1 I | 1 100.00.10 1 11 11 too.00.11 1 11 11 100.00.M 1 t1 11 11 11 11 t1 11 11 11 11 1t 11 11 t1 11 11 1I 1 1 100.00.10 1 11 11 1 11 11 A A 11 |A |4 f 11 | 01.10.10 1 lf.OI.4l i 11 1 1 t 14.10.17 1 21.00.70 i i i t1 i i 00.00.11 00.01.71 i i t i1 |I i t t1 i i1 t i1 i 1i t1 i1 t1 i1 t1 1 11 t1 t 1i tt ii t i 4. 1 j___ t t U.04.SI 2A.11.24 i i1 k 1 |1 1 k 1 11 3S 41 44 J- t i t.. I i i i i i i 1 1 1 1 1 __J__ 1 1 12 13 21 12 1 12 123.01.69 tie. (N10SH) i 1 _J J _i i it i t 11 114.12.71 ttmm (NIOSK) i | Polywrler i 1 1 Poly worker 1 k 1 t ! lt ii 1 11 1 1 IA 110.10.7} |Yea (N10SH) 1 I 11 k 1 |FI 1 ling (peatIcide (Reported tmJej |non polyer- I 1i I 1k 1 11 1 latroioi c*ne| k IwItA VC 11 | laacIon |worker* In (HlOSH lint of I l1 I 11 1 14 (1 11 *1 |H .3.7 2. |Thla of cihiioc (la atrUt 1 y 1 11 1 11 1 11 l 11 t 11 11 1 11 k 11 1 11 11 11 1( 1k 1i 1l 11 1l 1l (correct. (However 1 (wonder | whet Iter iltta lean had high feapoaure to |VCH in hia (can filling (opcratIon? ! 1A ii __ i___ ________________ 1 11 i* I I 12 123.11.24 I Yea (MlOSH) 1200 -SCO ppe| Poly worker 4 | L93H was |CIInicai f ti Ibut high (temporary |autocleaner (detalI In I 11 (during 1 ft(autucleaner |for 1 yr (paper by * 1l |iutocUMr| (Cokel el at 1 11 k1 (VI i chow a At i it 1 1i 11 |A Path IV76 |H2 CMA 0 1 0 1 7 4 l PA GERMANY Shct 2 1C I CHEMICALS A POLYMERS LIVE! An|loiitcoaa Ctici - IRvUh Date: I Jan 1989) 10 12 n WPX/ASL - LAMClOCASES.ib country and reference UAHS GE DATS or INITIALS I1ITH GERMANY 1 | 1 OS | | (NiOSH glvaal a. Ca.a Ott 1 | | 1 1 04 I 1 (H10SH glvai a* Caaa OS) i i 1 100.00.34 | 1 i | | | | | | | | | | I tt 1 100.00.32 1 u 7 02 00.00.IS 00.00.IT rim vc FACTOR* ljUomM 1 1 1n 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 l 17 1 i 02.0*.tO It.12.42 DATE or DIAGNOSIS AGE AT DIAGNOSIS YEARS or EXPOSURE TO DIAGNOSIS YEARS OP | OATS OP EXPOSURE | DRAIN HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS ii ii 1 1i 1 1i i1 11 J 4 1 (Cunt 1raed 10.12.11 1 i i i 1 I i 1 1 1 i 1 I 1 i i 1 i j__ 1 00.00.7S 1 1 3R A3 i i i i i i i i i i i i i i --il-- i i 13 13 1 OS tit.12.J* | Vaa (NIOSH) i 11 i 11 i 11 i 44 \ 11 i1 i |i i 11 i I1 i |i i 11 i |i i Ii i |i i |i i 1i i 1i __L_ t _j_______ 1 1t i 12 109.01.73 1 Vaa i 11 | i 1 1 I 1 1 1 \ t 1 1 1 1 i 1 i 1 t 1 1 1 IRC Cheate | laays | (Vhealatry | |1aboratorlan| |In the | |Techno- | lloglcal | (Reaaarch | | Department" | UtnOSH aaya | (factory | Jc heal at | (which aay be| |wrong ( |traaalatlon)| 11 11 11 11 (PVC - Hanu- | (factore | Shill Leader (Reported under |non-polyaer|laatIon (workere In | NIOSH Mat ot | 11.3.7/ and I l.M. 1 dor.' 1 (think thl* la (a correct (claaalt teat tun |by NIOSH. The (aan aay have (been Involved (In VCH |polymer(eat tun (In pilot plant |or In aaln (plant. i 1 1 1 13.04.34 12.II.IS At 19.07.bA 0A.0A.7S _L I 21 |I3.)I.7* <141 OSH | aays 12) | _L I 20 I2S.I2.7S 1 1_______ PVC Manu facture and all work Inc I auto- cleaning 12 yr* (19S4-to6) foreman Tech Dev 8 yre ( ft967-im> Polywoxker CMA 0 1 0 1 7 5 Page GERMANY Shttl 3 12 1C I CHEMICALS i POLYMERS LIVER ta|loirc<)M Caeca - (Review Date; I Jen 1969) 12 WhX/ASL - LANGIOL'AbtS, I / COUNTRY AMO UMCt NAME 00 INITIALS DATE OS 0I0IH COMPANY FACTORY nur c DATE OT DIAGNOSIS AGE AT DIAGNOSES YEARS OF EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL COMP1RMATIOH ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHtK COMMENTS 09 00.00.34 10 (NIOSH give# ll> 00.00.34 (NIOSH give* 10) 12 00.00.29 00.00.30 20.02.41 14.04.24 41 IS I) 24.03.78 Yea Hl|h peak* 12 yra poly- tiorker Incl 172 auto clave cleanlng Control rooa I yr 01.01.41 00.01.77 40 14 10 07.03.77 X High peak* 10 yra polyworker incl 172 autoc lave c leaning 10.10.55 20.04.77 47 21 22 20.04.77 00.00.41 00.10.77 14 07.10.77 Nigh X 3 yra eut cl eve cleaner 19 yra litter operator _L PVC Manu facture Aut octave worker tor 6 yra 10/70 Coni 1raed Average eipoaura 111* 9 yra ISO pp* occ 1000 ppM Neat 3 yr av 7S ppa. U( yr av IS ppa Average expoeure I 1 rat 9 yra ISO ppa, occ 1000 ppe. Laat yr av 7 S p[a. CUH letter ot lI.04.m CMA 0 1 0 1 7 6 Page GERMANY Shed * country and NAME OR INITIALS OATt or BIRIN I Cl CHEMICALS 4 POLYMERS LIVER Aft|lMft(coM Case* - (Review Date: 1 Jan 949) WPX/ASL - LANMOCAbtS , U3 ryr 4 COMPANY j Piisf~wT FACTORY | EXPOSURE I BATE OP DIAGNOSIS ACE AT DIAGNOSIS i nr YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE II DATE 0? DEATH 12 HISTOLOGICAL COMPIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION IS HICHLICKTS OTHER CUMMENTb Germany i) 14 00.00.14 n (NIOM *tM (hi* h 13) "IT tonr 66.8&75T 04.04.74 43 TOOT h.iot TT TOir TOOT" (Leiheck euapactad ASL at Pah 1923 laparotony) ~5T 14 ir ~TT 14 19.03.24 Yaa ir 20 Aag loeercuaa In bla lactar of 21 12 41. I* Prledel aid thla waa a *PlettenepitkeUuilMa Dai' Bpalaarobra** (a carcinoma of the oeeopbagua) not att rlbuta41a to VCH A aot recogoieed aa an ioduetrlal dlaaaaa X t1 11 6T.04.TT J1 \ Yaa I |ASL and f |Hepatoce11ular| |Carclnone 1 J1 11 11 11 1t 11 11 1\ High Autoclave cleaner and worker. Drier operator. Later ehllt | leader 1 1 ____ ____ |Autocl ive (worker tin tm*. i (Leader and laaater 1 1 1i 1 1 1 1 1 P W Meet letter ot 10th June I9dtl enclosing data t roe Hr H P Pried*l ot RC Chewle P U Beat letter ul 30th June ISRO enclosing data f rua M P Piiedel ot AC Cheate withdrawing thla caae Angioaermaa coni lined 09/79. Sow det al 1 ot t h I u 4 alio canea 9. M. I*. Ih |4 17 given In IHKU Hepoit lor j 1924 | AoRtosacciin* (coat 1 raeil, |tul1 del alia |of 11 Ineat, |eince Henli | 19 7 3 K^ru In |MRU Ned ln*p |Rep toi |9/4. IDlt t elent (del alia ((1 (In "VC | Aaruc lit ed 1/ibearr by |.e I l>l<. li KdibiciI* r ( 19HI I |7 I . CMA 0 1 0 1 7 7 Ft 14 Germany Sheet 5 ICj CHEMICALS 4 POLYMERS LIVER Angiosarcoma Canes - (Review Date: I Jan 1969) UPX/ASL ~ LAHCLOCAi.fcb.1V 1 1 | 1 COUNTRY AMD REFERENCE I NO 1 1 2 MANE OR INITIALS 1 11 1 1 DATE OF l mm 1 1 1 4 COMPANY j 6 1 FIRST VC 1 FACTORY J*W*M i1 1 7 DATE OP DIAGNOSIS 6 ACE AT DIAGNOSIS 9 YEARS OF EXPOSURE TO DIAGNOSIS 10 YEARS OP EXPOSURE 1 11 12 1) i 14 | DATE OP DEATH ___________________ ! HISTOLOGICAL CONFIRMATION L1 I1 ESTIMATED 1 L EX POSORE L OCCUPATION | LEVEL I ( ____________ ___________________ ______________ 1 1 15 OTHER (fAREEK HIGHLIGHTS L Lb OTHER OOMHENTb GERMANY 17 (KIOSK five# aa Cue IS) 00.00.17 TT M.00.11 01.11.61 14.Qt.7S 41 U 11 26.06.76 06.00.ti inrir sr TT sr IJ.1J.71 High Autoc Lave worker Autoclave Worker Angloaert oa coal I laed. Annual repoii of Ihe North Rhine Ueatphalla Medical Inspectorate for 1976 pages 14?- 17? gives lull details. Vinyl chloride d laease diagnosed 02-02-)!. Oeaophageal varlcea. Rsdlolugli ally confirmed aero osteolysi a . TT TiT 21 o 3: 21 HOOT 60.A0.I5 00.60.iJ 60.00.il II.16.SC vrsrrr TT lV.SJ.iT THTSTTBr TT St.6f.if 6S.64.7r" pronounced cHaicsl 1 Iver aptoss) 15.10.61 irarszr 59 25 TT 16 "75" "TT iT.Girur (u Netutulng TT TT 1*.IS.oo r. HMSltflO Endothelioma of liver with l4.oi.ta X III HitsIB|1o Endothelioma of liver with 06.12.61 Yea HetaataaIng ASL Hl(h Autoclave Worker High High x Autoclave Worker | | \ \ I i_ Autoc Lave Worker and | worked In | drying shop | I HIKh Autoc Lave Worker |Chargehaud, | subae<|ueitt I y |tor email Dr Beeche letter ot I1-U4-B2 n. D( V U' Ada* Dr Besche letter ut J1-04-62 t Dr W C F A Dr Best he lectet <tt I 1-04-62 Dr U L. h ill he J 11 let o I fl..' pc W l. t SCIO TO PK b CEMMMV Shct 6 IC1 CHEMICALS i POLYMERS LIVER Angloaarcoma Case* ( Rev Date: 1 Jan 1909) WPX/ASL - LANClOl AbLb.20 II 12 I) 14 COUNTRY AMO REFERENCE n NAME OR INITIALS OATS OF 1IRTH 00.00.27 COMPANY FACTORY FIRST VC | OATS OP llRpgpi | DIAGNOSIS +t '.* -i 2A.03.79 ACE AT DIAGNOSIS 32 YEARS OF EXPOSURE TO DIAGNOSIS 29 YEARS OF EXPOSURE DATE OF DEATH 21 29.09.01 HISTOLOGICAL CONFIRM ATION ESTIMATED EXPOSURE LEVEL OCCUPATION High Cheatatry t*WO ppm) Worker TT 66.6673" Twr TTTIOr TT ir iOOI Sigh Autoclave ('0 pp>) CUintr OTHER CAREER HIGHLIGHTS || | ] OTHER COMMENTS I |Prleery hepalucellac (carcinoma; (proliferation of the (Inualodal cello with lilouiolJal eclaala. IFrledel letter 21.12-06. 1 |Prof Mr (Munich) lletter 22.06.01. iPrledel letter 19.09.0b. ---------- 25 IT norm--sr-| ---------- (557TSOT i--i--i--t--rrear-- | | 1 11 i i | | 111 i i 1 _J___ I I ii -j____ _i.i-- i ii ...1.................... i i i i Ik TT "66.66714 ir II.Ik.11 TOT U.6T.IT TT 0I.I0.U 11.00.*5 TT ir ir t n 3: rr > o 51 o I-* si 12 'O "6675T.il" 66.66.17 oo.oo.il oo.oo.16 mr TOT TT5T 1*55 lT.T5I.4T 0T.6t.l6 10.66.45 06.61.4T fr TF hi TT 29 "52" 50 i "IT i i 1 1 IIA.0i.l3 | 1 1 1 1 1 i SiT | High iPotycleva | |Worker and | (Autoclava | tCIaaner i............j . | | | 1 J______ ... |Prof Selmair (Munich) lletter 22.06.6). IFrledel letter 19.04.0b i !- TT 4J.61.4f r.. TT TOUT Tee High High Autoclave Ciaaner till 1912 Proceea _L worker 1997 64 (01.10.40 -31.01.64 PVC product- Ion, |lttor area). ~VT I5.0l.a4 High Cheelat ry worker |anj(luatu la t ilnurokdrl lectaala. Frledel lettet 121.12.04. |Lei bach. _____ (Frledel letter 119.04.6b |Annual VCH screening 124 .04.6b: no complaint, (no abnormality detected. 12970 tuo-thlrda Jgaatrectumy for ukent. f 1971 Coronary throaboala 11963 Feuorai | ImplantatIon 11964 Pulaonary em hollas (and pieuropneumonI a. |Lander* lettera 16.09.Hb (and 04.02.67. J___________________ (Haemangtoearkoa*. IFrledel letter 2).I2.H6. ~ir J1.6T.41' 10 All..? Alivct Hlgh Polyworker Shift leader Aut-oc 1 ave c leaner Polyworker AiiliK-1 awe ileaner |Haemang1oaa rkoaa. IFrledel letter 2l.ll.dti. J___________________________________ | Haemang losarkua. IFrledel lelUi no. J (Haeaa <ig I at ark oea. IFrledel letter Ps JTALV Sheet I 16 IC1 CHEMICALS 6 POLYKiKb UVKI Ad|toircou Caeca - (Review Date: I Jen 1969) 1 COUNTRY AND RenUNCK NO TfAVt 01 (On N10SM Met ary I let) NAM 01 DATS or initials lira 15.06.16 COMPANY PAMSAC fACTOSV HI re Venice rust vc Uv 00.00.41 OATS OP DIAGNOSIS 19.04.71 ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS 06 10 YEARS OP DATE Of HISTOLOGICAL EXPOSURE DEATH CONriRMATION 01 16.04.71 TYee 1) I ESTIMATED | EXPOSURE | OCCUPATION LEVEL | X I IPVC Rft jciUeter l I I I WHX/ASL - LANCIULA^CS , M OTHER CAREER HIGHLIGHTS OTHER COMMENTS Prleery tumout ay heve been per lcrdlue. Not hiwiogeneoue with other crtei. 02 01 VC ti.n.2* NoeteHieoe Porto NergNere 00.00.57 11.12.72 16.03.20 Soley Re r re re 00.01.51 10.07.75 61 55 22 06 r 20.07.37 AN 1C 00.06.59 00.01.SI 21 C Oeneele 19.01.17 PANSAC Hire Venice 00.00.67 07.01.67 06 27.12.72 10.07.75 21 10.01*61 06.04.S3 Yee Yee Yee Nigh |Polyworker l J_______________ X I |Autocleaner 1977-5 did IS yre (195) e verlety ot |6i) Autoclave Jobe loperetor Includlng |12 yre (1961 I 7 2) PVC packing. 12 yre - 11 y r Very High | Itonoaer Never cleaned aut oclevee. loperetor Sec peper by 5 yre - 1 Herflue (20 yre - CHIAPP1N0 et el Ned Levoro | Autoclave Vo 1 6 (1962) 4 yre - loperetor 4 pp 555-561 lotlier dot lee (In euepena- Jion polyner- IieetIon. I |Atee Po tenon | lit tree Dept jalnce 1975. Medlue-T High j________________ I |Rag eat rude | 1967-1975 (Dept 1976| 1961 I Non-aauker . Concerned little alcohol. Nu A0L. S Pag J I a I mi lelea ot 2 Aug 196 ) See Me It uni He4 4i Lavoro 65 p445, 1974. .further detail* In letter Iroe Dr Nonteeeno ot 1ARC on April let 1962. * Alao wee Helton! end Rondlnella in Acte Oncologlce Vo I I I960 page* 75 - 49. CMA 0 1 0 1 8 0 Page JAPAN IS I Cl CHEMICALS 4 POLYMERS LIVER An|iaai[cou Case* - (Review Date: I Jan 1989) WPK/ASL - LANL LOCASLS,i1 10 12 1) kb coutim aw UPUINCI MO MAMC OR INITIALS DATS OF | BIRTH | CQtfAMY I ________L I I 01 Toeojt 01.OR.22 |Ml caul Nor I IlMtM FACTORY Nagoya 02 SC I I I I I I ______I______ 02.00.19 JEanegafuchi |Ch--teal I 1 PINT VC 00.04.il 00.11 SO dare of DIAGNOSIS 24.IO.7i 10.06.76 ACE AT DIAGNOSIS S3 YEARS OF EXPOSURE TO DIAGNOSIS 22 YEARS OF EXPOSURE DATE OP DEATH 13 24.10.PS 13 10.06.76 HISTOLOGICAL J ESTIHATtO CONFIRMATION | UPOSURE | LEVEL 1 I L OCCUPATION |PVC Aaaoc 1) yra auto- | tap* not c lave (known, c leaner j* Japan 1964 - |Tl*ee aaalgned to |indicated different |on 25.10.75 work alnce (eapoauree had 111 Joften at health 13000 ppm up | to 1974 jI In polyaer- laation work 1 deludlog autoclave cleaning OTHER CAREER HIGHLIGHTS i)THtk COMHENIS Japan Tluea 25.ID.75 4 Japanese PVC Aaaoc letter* ol 3UOJ.7B 4 30.Ik.67 Japaueae PV Aaaoc tailon ietteiv of 11.03. 4 ID.LI.67 03 01.09.30 lltttMl Nage?a 0.07.61 26.06.61 14 20 IToatnu I I 14.09.65 High 5 years Autoclave cleaner Let tei 11 o* Dr Nakdauri, Japaneae PVL Aaaoc I VC Ion 10.J1.67 CMA 0 1 0 1 8 2 Page 19 NORUAY COUNTRY AND amunct NO OR INITIALS OATS OR SIRTH COMPANY 1CI CHEMICALS 4 POLYMERS LIVE! Afl|loitrcoM Case* - (Review Dele: I Jen 1999) MPX/ASL ' LANCIUCAbtb , i d 10 J1 12 run vc DATE Or DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSES YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATE!) EXPOSURE LEVEL OCCUPATION OTHER CAREER HICHLICHTS OTHEH COMMENTb 01 21.12.13 Ibrck Neropa 00.03.90 21.12.71 Hydro 22 21 04.01.72 High Paresan 4 Autoclave auffrerviaor Coal I rmeti by Dr ThlleEvanaen ut NH. At APME Hr g ol 9 June 1976 Mr P ftangnea stated chat AH had been a aeaber at a atart-up teas. VCH 4 PVC were adc In teu building. The VCH vaa aude fro* acetylene CMA 0 1 0 1 8 3 Pag* SWEDEN ICI CHEMICALS 6 POLYMERS LIVER AngloaxcoH Cases - (Icvltw Data; I Jan 1989) WPX/ASL - LANClOCAStS, 2`j 10 COUNTRY AMO rotrence MANE OR INITIALS MTS or sum CONTAIN | FACTQQI nin vc DATS or DIAGNOSIS ACE AT DIAGNOSIS YEARS Or EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTIitA COHMLNIb I I 01 23.06.27 I--isail ISaaltvaU 14.08.SI 20.10.70 43 19 20.10.70 02 27.11.11 Kasasorl |SualavaU 00.01.43 00.01.72 61 27 27 16.06.72 03 10.06.10 aaarl iSuedavall 00.03.47 16.03.76 63 29 19.03.76 16.11.14 KaaaaaU |SuaOiI! 00.00.46 12.05.77 62 31 31 12.05.77 I I I I I I I I I I 05 12.03.19 Eestesord | Sondsva I1 11.05.64 22.11.60 61 16 16 22.11.60 High Po L/worker VCM produciIon High Nigh Poly worker X 194b-1958 poiyne rlaalIon worker (12 yrs) 6 19581977 fureuu (19 prs) High b Years Low - 10 Years 1964-19/0 cent r11uge operator 1970-1980 drier ope ralor I |Nr Sf oe11n * a (letter o| | 26 Htuh 19/8 |conf I im 1L (was s aoriMct Iwurker who h< | heev 11 y Jeaposed, (probably even (ore so (lieii (a noraal (reactor |c Issuer J_______________ X 11n t ln>[ I 2 lyra ol leaployweni. had | been hes vI Iy Jexposed. in (1974, il*e | abnorea1 try land necrosis (diagnosed. | Dels Cuilt lini-J | In 04 0 bye e (let t rr IB.H.M (to CLt 1C I |Let lei ut |2ud Nov I 4 tt I II run (Dr David byi I CMA 0 1 0 1 8 4 In bis letter ol Ut April 1942, Dr Itontesano of IARC saya In Sweden's National Hoard ot OS Health gives 2U-02-70 as date ol diagnosis Case (Jl and 15-05-7 2 lur Cae 02. Page 21 UK Sheet I ICi CHEMICALS 4 POLYMERS L1VCI ta|lottcoM Caaea - (Review Dele: I Jen 1909) UpK/ASL - l.ANC. IOC AbfcS , i b 13 COUMTM AMO lErEUMCK HO MAIC Oft INITIALS DATE OP ism COMPANY PACTOtT nut vc DATE OP DIAGNOSIS ACE AT | TEAKS OF DIAGNOSIS | EXPOSURE TO | DIAGNOSIS _________ I___________ YEARS Of exposure DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COHHtNlb 01 20.04.01 ICI HIUImmm 04.04.44 03.12.22 n 2D (Fob 4 Collier P*P*r 23.12.12) 02 03 02.04.31 04 JSt 23.04.20 Berry 00.02.44 00.12.14 24.04.S4 00.04.19 I 31 | 09 I I S9 I 25 22 03.12.12 (Foe A Collier paper eye 23.12.12) X X 1.3 24.12.14 10 12.10.19 300 ppa J944-1 VCN 1941-8 Drier I94B-41 Autoclave operator 1941-44 Drier Lee and Ha i < y Lam el 29-06-M page* l I 16 0 Dub Iuuu fabric*!. I High Antocleve cleaner Eipo* u e Halted Ui 2,66 - 9.t>9 Nelliehigh 54-5 Aegtftng Plant 55-6 Drier Plant 54- SR Au toe Iave worker 38-61 Chargeband Drier Plant 61-12 Foreaan C 2/3 Plant Pre-war tlah pat her I91I-M .ray vehicle alntenance I lab pacher VWD io-- o CMA O lO lg ^ Page 22 UK Sheet 2 I i--r COUNTRY AMO REKUNCK MO UK OS MAKE Ot INITIALS turn OP R1RTH 10.01.14 COMPANY Barry "58" cET 19)1 nr U3 H.M.lO "55" UTH 6TM7TC larry EfrT Barry ICI CHEMICALS A POLYMERS WPX/A5L - LANClOCAStb./l PIRSt VC upoauu 1.01.51 w TKT LIVER ringloaarcoM Cases - (Review Date: I Jan 1989) i DATE OP ACE AT i ~9-------------i--------- re" YEARS OP YEARS OP 01AGH0SIS DIAGNOSIS EXPOSURE TO EXPOSURE DIAGNOSIS rr DATE OP DEATH 2100.10.79 65 29 19.11.79 TI" HISTOLOGICAL CONFIRMATION TOOT wr ir ir 69.OI.tA SOOtT TT tr lonr n ESTiMATED EXPOSURE LEVEL OCCUPATION 1951-52 Folyc Leaner 1952-55 La tea 1955-60 Polyflour t960-64 Poly Chargehand 1964-70 Charging operator 1970-72 Drier operator 1 yra Poly Floor Operator 5 yra Greaaer on Poly floor Polycie 1961-5 Recovery 1965-1971 i5 OTHER ' CAREER HIGHLIGHTS OTHER CUHMENIS n..w TTTOT tt TT TT i5.i5.il TTHP755i 500 ppa 1968-1974 200 ppa 11950-51 |Autoclave |1918-J948 (Motor Mechanic (operat or |1948-1950 |1951-1957 (Operator on fChargeaen (Acetylene |auioclave | product Ion |bu!Idlng | PI ant 11957-1974 iShltc {au|>erv Jaor lautoclave |bulIdlng |Never |c leaned utuclave* ( 1 1 L ( 1 1 but aupervf nor 1 a Job ent aI led ruttflog utot I ave b to I ob pee t 2) UK Sheet 3 i COUNTRY AND reference NO 09 NAME OR INITIALS un or RIRTH 07.05.23 10 04.04.4/ Jt'l CHEMICALS 4 POLYMERS UKK/AM. - LANCiOLAStb , 'fl COMPANY FACTORY F Barry LIVER AnflMarcoM Cie - (Review bate; I Jen 1969) T 10 11 TV 13 15 FtRSf VC OAft Of DIAGNOSIS l5.fU.30 02.03.43 2/.04.44 01 05 B4 ACE AT DIAGNOSIS 3/ YEARS 6r EXPOSURE TO 01ACH0SIS 33 YEARS OP EXPOSURE DATt OP DEATH 29 24.02.43 4.2 I4.03.t4 NISTOLOCICAL I ESTIMATED CONFIRMATION t EXPOSURE ^ LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 1 Tee t Hcdluw Polyvurker 2 yaara on Acrylonitrile i Reals Plant. I Alao prior to I 1950. 4 year I RAF I aintenance. I ) year* eotor car paimahop 2 year* In Craving Dock. I |Hlgh - || _L Polycleaner Heavy goods |*onthe < 300 1944-42. vehicle drive |pp). low- Spray-drier unt11 fInal I It eonthe 1(50 pp*>. bg|cr 1967- Ilinee. 68. IHedlue - low-down |21 wontha at ripper 1(200 pp*> operator I i968-20. OTHER CUHHtN I It InlorwatIon given In letter 18.06.84 lio Or D N J Hi illawe 0R.03.2t _L Barry 19.12.45 02.04.45 5/ 19 14 02.04.45 _L IHlgh |1965 -49 |*ted 49-/9 |Low 29-42 * \ I I I I Polycleaner 1965-68. Service operator 68-69. Poly Operator 69-79. Leading Hand 79-82. Letter ut 04.06.65 Or Paul Saliii and letter ut 04.06.83 Dr DID t.4iia Oesophageal aorrhage doe < o oesophageal varices due Uj Angloaac cosj ot liver 12 24.01.3/ ICi Hllihouae 16.09.57 03.04.85 _L I 1 Low 1957-59 Spare msr. |Hlgb 59-74 (Low 74-85 i begging t Loor 195/-39. Auioc Lave 1 Operator 1939-85 I I .el I ei 6.00.63 Dr E l l.e CMA 0 1 0 1 8 7 fC* 24 UK Sheec. 4 ICI CHEMICALS 4 fOLKHEItS | LIVES Angiosarcoma Caaea - (Review Data : 1 January 1949) WfM/ASU - LANL LoCAbLb , b COUNTRY AMO HAHE OR DATE Of REFERENCE INITIALS 1RTH COMPANY 10 I 12 n FACTORY FIRST VC YEARS OF uts or ACC AT EXPOSURE tears ori oats or 0UCM0S1S DIAGNOSIS TO EXPOSURE* DEATH OIACMOSIS HiSTO- LOGICAL CONFIRM ATION ESTIMATED) EXPOSURE LEVEL X XX OCCUPATION OTHER CAREER HIGHLIGHTS OTHER UJHHtHTb 02.03.4S 1ST Barry 196* Jw 14 3? IS (02.0S.SS 1 Yaa 1 Hth (Polycleaner 1 11 11968-69 (Moved to (Remained well, working | Acrylonltrtle [actively, until Jan 1986 1 1 1 Low iCantral | Plant unc tl | 1 1 | Da pot (left BP 198). | 11 *19*9-70 (Manager of 1 1 i m**> |Polyfloor J1C * SS Ltd at 1 11 |19)0-1971 (Cardiff Airport* ; 1l |198)86 X |1 i i1 14 I3.0S.42 1ST Carry 07.0I.SS I27.0S.S) 43 21 II I0I.12.SS i Yaa |10 months |Polyc leaner |i |Let(era from Dr 0HD Evans, (Pathologist, Penarth, Wales | i |10 yaara * Polyfloor (and Dr DM) Will leas, BP, Barry | 1 |CMatMt (worker at claaal 1 1 |Madlira |between i 1 |6ot oa I196S-I9S2 latar- 23.00.21 |BT Barry 1934 I9SS is 23.03.22 | ICI HUlfcoaee(J9*3 I9SS XX 32 | 01.03.SSI Yaa |9 yeara (Poly claanar 4 Information from HIrS 3 yaara Udit (Operator Eapoeure (Blow 4 Recovery perloAa | Of# rat or lateralttent Dr 0 H J Williams. BP. ami Or Paul Salth, Pathologist 2 yaara lUtlllt y (Operator j-------------------------- X 12.11 Packer Auloclave Operator Hepatic fibrosis 19/4 Oesophageal varices Porta-caval shunt 19/i Information troa Ur Benin-1 i [Cl. and Dl I I Lee, UI at 4 |n,u ] Victoria Hospital J9B8. 8 8 T 0 T 0 VW3 USA Sheet I COUNTRY AMO KIKttilC* HAW OR INITIAL DATE Of RUTH 01 Ear I 17.10,23 RFC Nika 02 If.00.33 03 Uwart 23.03.13 Meulddi* 13.01.24 RFC 03 23.01.12 RPC 06 Ray 23.11.28 RK kiltla 07 Charles 03.03.22 T Heart 1C1 CHEMICALS 4 POLYMERS LIVER Anglosarcoe* CAiei - (Review Dele; l Jen 198V) UK syatee o( <Jjteu DAT - MONTH - VLAN WFX/ASL - UiNO UH^Al>t'j , !H R1RJT VC date or DIAGNOSIS Loutavia* Of.12.A# 03.03.73 Loulavilla 13.11.33 00.03.70 Util*' villa 26.11.45 19.12.73 Lout*villa 04.07.32 If.06.67 Louis ville If.06.44 Of.04.64 Loula vl lie 17.01.62 00.02.74 S Chart*- 27.OR.44 atoa 00.00.6R ACE AT DIAGNOSIS 4f 37 43 32 43 TEARS OF EXPOSURE TO DIAGNOSIS 14 26 12 10 II 12 YEARS OF EXPOSURE DATE Of | HISTOLOGICAL DEATH | CONFIRMATION I 1 I I 03.03.13 1 I 1 I I I _L 13 27.09.71 | (NtOSN I aajra I 26.09.71)1 ____________ L 26 19.12.73 | I I L I 13 07.01.66 1 I ________L 20 Of.04.64 | I L I 12 24.07.73 | I 1 17 23.01.68 13 1 ESTIMATED EXPOSURE LEVEL OCCUPATION Pot Cleaner ( Block Jmi 1974} p 13 Pot Cleaner (Cl block) OTHER | OTHER CAREER | COHHENl^ HIGHLIGHTS I J___________ i History given 1 Roll tog iilmtc In Annals NY | Art ACAD SCIENCES 1 Rel J NY At Vol 12V (IV7V) |of Sc Syep page 190 In Paper by R R Cut t Le ( 19/4 |Akao block |J**a L./.74 OSHA Ip 3 3 L I ]Ret 1 lAUo block ( JAHA 1. 7. 74 fp 33 J_____________ Pot Cleaner (Ct Rlock) LoulavlIle Couz ler Journal 02-09-80 Pot Cleaner (Cl Rlock) I Ref 1 |AJao block I j_______________ 1 lltef I |Alao bio I Pot Cleaner (Cl block) US Ai r Farce Pot Cleaner (Cl Rlock) (Rel i (Also Rj j_________ | Rel I * J Luul h v l l l e |Tluen 2 1././') | Re tit eil Af i i l ll 974 |Also bl.u k J____________ \ (Re# I 06 06.03.20 Goodyear Niagara 07.10.46 00.08.61 13 |*et I roro vwo CO USA Sheet 2 COUNTRY AND reference NO NAME OR INITIALS DATE Of ftIRTH III CHEMICALS A POLYMERS LIVER Anglosatcuna Cases - (Review (late: ( Jao 1909) UK uystea at dateb 0AY - MONTH - YEAR UPA/ASl 2 - LANCtOLASL!:., I J2 13 FIRST VC urosuu DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION j OTHER CAREER HIGHLIGHTS uihtk COMHEN IS 09 layoond oe.ii.3i CattlePlaferT Louis ville 21.OS.A) 0i.01.7A 29 ll.03.7S 10 ti.oe.n Goodyear Niagara 12.OA.SI 00.01.Aft 55 17 W 10.05.A 27.05.09 Goodyear Niagara IA.10.AA 00.03.70 Al 23 23 IA.03.70 12 Prone la A 7.11.18 Pot t a town 13.07.49 Pa 02.05.A9 50 20 02.05.A9 13 Richard 01.12.21 UCC Edward Cleodeoin ll.12.A2 00.05.74 52 07.0A.7A 2000 ppe Ret I lias VI OUg t tgll [CM re I itst tKpoauic, Lou lev I Me Tlsea 29.10.74, 12.1. 75. 10. J.7fc High 10 yrs 10 yrs as reactor op. (not cleaner - separate crew cleaned autoclaves) Ut 11 it y A Service op. aKgtr Dryer up. Stripping op. 1 yrb prlur service let tyre plant 2bRet 1 t lettci ut April mti I rus Rusae M A Paik to J T Scab* 1 l ut HI A 2000 pp t-liar J e b 1 mi Dally Mail 21 . J.h Never dia* liused as ang lklbdl 1 nBJ uf l Iver . tut t>i al tmi glvdii 1 kllfl 21 Ha j I9B4 t l>s J A SaIg. AS! J*'IM * `lJ`*s CMrt 0 1 0 1 9 0 Page USA Sheet 3 1C1 CHEMICALS 6 POUHERS LIVER AngioearcoM Caaea - (Review Date: 1 Jen (469) UK Syatea ot daiea DAK - MONTH - YEAR UPXMSL 2 - LAND IOCASLS COUNTRY AMO REFERENCE NO NAM OR INITIALS DATE OF BIRTH * | FIRST VC FACTORY | UF06UU I ___________ I_____________ DATE OF D1AGNUSIS ACE AT DIAGNOSIS I YEARS OF | EXPOSURE TO 1 DIAGNOSIS | YEARS OF EXPOSURE _________________ L DATE OF ) HISTOLOGICAL DEATH 1 CONFIRMATION I 1 ESTIMATED EXPOSURE LEVEL OCCTIPA1lUH {/THEN CAREER HIGHLIGHTS I I | | | OTtltR CUMMENI^ _________________ i________________ Jmci HoMird 04.11.2) FC Loulawill* oe.os.50 00.00.69 41 27.03.69 1911-4 VCH pa | yme i leecion Fru* (914 (Table 4 In onuarda Ici |Wagoner Arey and other (Teat iuoiiy to acrvlce. I US Senate 4b-SO Amy l Con timed In |M H Johneon (Hr 07.00 . f 0 17 IVtrnbMal 06.0S.1J RFC Charlie Arthur 22.04.26 PC UnjIi' j villa | 23.06.15 I I I I ________L I Avon Lekel 15.09.54 I I I I I II.JO.74 00.00.75 43 19 21 | Yea 16.10.60 ( on II.10.74 ( but ao | port -ai>Fiea | I6.10.R0 I L I 02.11.75 | Yea 1 I) yra Navy autocleaner 8 yra on Eatol Tyre Store piaat It laer 4 Carboaet operat Ion 19 Virgil 00.00.15 Ctirlatiao 5 Charle-| too | 19.06.75 60 32 32 06.04.76 i I 1 I ________L I 20 31.08.17 Goodyear Niagara 1 00.00.55 30.01.76 58 I 30.01.76 J I 21 Cheater 02.09.09 Hinkle 1 I S CJarle-| 00.12.46 ton I I l I Early 77 02.01.77 1 | ( ( I 2000 (Dr H N JuImiaoii lletter ot (24.2.81 .'IfiraeJ (Jedllt (6 yeara atlei jdlagnuala_______ (Cool 1 rued in |H N Johnuun Jltr 07.08.78 |Alau Rol I 1ng (Stone nag. |IS.U1.76 J___________ |W11 Uaaie(H>i L |Sun Caret t e (21 June 1971 iCYiarieattxi fUal ly Natl |2I.7.75 J I (hi OSH l cl ( i-1 (ul 71. in. / `t I 28 n |UCl d | Ke( i i CMA 0 1 0 1 9 pigc USA Sheet 4 2a 1C I CHEMICALS 4 P0L.1THfc.US LIVER tegloiarcou Ceeee - (Review Date: I Jen 19E9) UK eyaiem of dateb 0AY - MONTH - YEAH WPX/ASL 2 - LANClULAStS,1 10 COUNTRY Am UPOCNCC NO NAME OR INITIALS DATE OF aim USA 22 02.10.21 "IT 00.00.1) ~TT Otarlaa Una rd Itoera TTW caarAmr riRST VC FACTQOp i IgNfWU DATE OF DIAGNOSIS arc Lout*- | 11.07.42 00.01*74 villa | I I I I I I I I I I Ctut to. it CM Chtotc.t ritcktoiii oo.6t.U S Qtatlt tea Tfir 04.0t.li 17.0*.tJ ACE AT DIAGNOSIS 42 M 40 YEARS OF EXPOSURE TO DIAGNOSIS TT YEARS OF EXPOSURE DATE OP DEATH 2R 04.12.74 "TT 501.71 HISTOLOGICAL CONFIRMATION fcST(HATED EXPOSURE LEVEL OCCUPATION I OTHER | OTHER CAREER | CUHNENJ S HICHLICHTS | _____________ L I I | Loulevl 1 ie |Tlaee 24.I.i6 |aald he wav (the 10th AS (vlctla at IRelle Lent: ul (who* ft had Idled by 126.1.74 | In Me ltiiti jut J6.trt.B1 |0r H N Joho |conl Ira* iltti |ie the |c*e devirlbed (by Dannatief IlMbucru i (w |in Veb I9RJ |Aa J HedJrliie I Voi ;o i2uu ------ST" (MIOSH iqi 14) rnvnr Choiengie- aercoea <E Real nek 1 26/2/79) jMedina to high for 24 yre lttl-45 non- 1947-49 wan |N H Uheeler oivent vinyl leeln unit and off end on Iabuuret liWtl uy (letter of j18.ft.77 tu |J Scaffold diepare ion have been ivev dec a IJ vinyl rev I ite eapoeed ae |Roee Kenfovkl unit tiret reactor (letter <it Utter cleaner (24/2/N_________ helper, then 1944 becane (I Kealnaki ehift ehift fitter lO Nov 1980) utility un 1944 he cane |eiRA<ac i l*4i ehift utility INIOSH will aao jret aln on 26.04.6') | cej(J olei bl*i. e eapluyaent wai (thi* Keof'taoai terainet ed (nay be *n<u I x (ated vl (h AM . CMA 0 1 0 1 9 2 Renova 1 fro ter confined in R Rani nek I let er ot S Nov CMrt 0 1 0 1 9 3 Page 29 USA Sheet b i I2 |I COUNTRY AND | REFERENCE | NO USA 1 i ham or t INITIALS l CATC or Rim 4 C0MTANY l |9 11 1 | FACTORY i i 8 FIRST VC urosuti Ji 28 1 Jobe Rerry(07,07.23 RFC |LouieIvlIU 1.10.47 |i | |1 |i |l |i |I |l |I l 1 I I 37 |J L | in.6s.it UCC IS Ault- | tM i | | | | "61.07.11' 1 -------n-- | | 1 i 11.61.'IT bU i 1rzwu= 00.00.4i | atoa 1 ---------- Ii--------- | | io |UW | iI II 2.I0.6J UCC i It Aerie- 00.65,41 I atoa | | 111.07.2> Taoeeco i iriMlaftoa J1.04.44 Ckaluli 1 | | | | |1 1 \i 1 loi.it.il UCC IS Aerie- ll.0S.4l ICt CHEMICALS 4 POLYMERS LIVER Angloaarcoea Caeca - (Review Date: l Jan 1989) UK Bytttn of date* DAY - MONTH - YEAR MrX/AbL 1 - l.AMClUCAbtb,^ 1 DATE OF DIAGNOSIS 00.00.77 (up to 2 yeere altar 4..th) 76.ii.71 6J.li.71 OO.OJ.W Jo.ii.4o OI.0S.fi 8 AGE AT DIAGNOSIS 52 (death) ii 41 71 SI 57 1i 9 1 10 i 11 1 1l 12 i n 1 14 \ lb 1 16 Ji YEARS Of | YEARS OF | DATE OF EXPOSURE TO | EXPOSURE | DEATH il HISTOLOGICAL | ESTIMATED 1 | CONFIRMATION 1 EXPOSURE | OCCJPATlOfi | OTHER CAREER 1 | OTHER | COMHEM TS DIAGNOSIS i 1 _i i | LEVEL J__________ | HIGHLIGHTS 1 11 !i 1 | 26 1 It |11.02.75 Yea lEapoeed In IVarlouw Job*] | R Kaailnakl (death) 1 1 (aaaa degree(ln PVC 1 (letter ot i1 I1 11 |to 22 (cheaicela (but aaln (plant* f roe 1 (cold rooa tu| ip..t. 1 | 26/2/79 and | Prut. Taabui .* (letter of 11 leipoeure (recovery tu 1 i9/im 1i |waa to VCH | PVC charging) 1 11 (probably (operator to 1 ( 11 |hl(h (put. l 1 11 1 1 charging. 1 < *i 1 |IIl Auguet 1 1 11 1 11965. 1 1 1i 1 |Teralnated 1 1 i1 17 i i. . 1 10 iis.ii.7i ((MIOSH 1 1 (euploynent I i 1 |Jan 1966 1 i Yea 1 High (Operator to (Eipoaure In (R N Uheelet 1 |10.10.76 (bulk aikd |(lr of 6 Ian l7 27 i laud C i |Daily Halil i1 1| 11 |dtaper*Ion PVC|1979 and laapufacture |Char lewtun 1 |Dally Mall |2S> | 1 1 1 1 1 | i 1 (30.11.78 and (R Kaalnakl U -{ n ioj.tl.70 j Yea i j_______________ i 11 126/2779 |R Kaulnakl i1 i1 1 (letter ot It i it --ioLi.-b--i.s-6-J Yea j---------------------- i i1 j 1 (6/4/79 |R Keelnekl i1 1) 1 (Letter* of 11 i| 1 (19th June I960 |7 j 1 _1__________ IS 1 Jo.11.so j j_______________ j Yea |6 - Unanoun|Maintenance 1 |t 5th Nuv I960 1 11 |9 - HIa fatal)Mechanic 1 1 * |6 yra 1 ( 11 i (Elaevhere 1 1 11 11 1 Ml yr* l 1 |Doller housel 1 1 11 1 |0perat or 1 1 95 i n ioi.04.Sl 1? 7" i j Yaa (High (But (Chest cal |Fri> 1959 Co |Dr Daiey not a* hlgh|Operatoc 1976 Aliphatic let tec ee reactor (charge Cheat cat* lb.lt>.til j.ui cleaner |react or operator and K N Whee lei would | Iron July 19/4 letter ot eiperlence) 1 Worked aa | to date Format* 9.11.81. A1 b o 0* Oai labourer trum | | At Iphat Ic Cheat cal letter ot ti/.ll J.fc 1 it June 1941 1 Ope rat Ion dale tit .U ji tv Mdy 194b) and nay | have | cleaned | t eai turn 1 ci | CMA 0 1 0 1 9 4 Page >1 USA Sheet } ICl CHEMICALS 6 POLYMERS Ut*/AuU - UlMuU^t'i.t* UK b>sle of dates LIVE,! Angiosarcoma Cases (Review Date; January 19B9) DAY - MONTH - YEAH i COUNTRY AND NAME OR DATE OF REFERENCE 1RITIALSI RUTH USA 37 Hr J Payton 2f.OR.29 38 28.08.22 Air Producta 39 21.04.181 O 3; > C<! 1 0 l9 , FACTORY FIRST VC YEARS OF DATS OF i ACE AT i EXPOSURE YEARS OF, DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATH n HISTO LOGICAL CONFIRM ATION X ESTIMATED! EXPOSURE OCCUPATION LEVEL OTHER CAREER i HIGHLIGHTS! X DIMER UJHHENTS Louis ville mi 06.08.64 34 31 22 06.08.84 (Ugh Worked regularly In FVC araa In the early days was a reactor cleaner 1953-73. Information given In letter 09.08.84 Iron Or M H Johnson Throwbo cytopenla and leukopenia since Calvert 100.02.83 If.01.8* City 61 20 28.10.83 Yee Nigh Normal 1963-1982 progression frost helper since 19/8. Gold treatment lor arthritis 1976. Under Dr*a care about 6 wont ha before death, had paased standard jihyvUsl to senior examination 1 wont ha earlier. J lair operator, letters of 22.10.84 and 23.Gl.B3. cleaned reactors, stripping and recovery areea ae well as charging operator. X Never In hospital for any chronic oi I960 March 63 24 23 29.06.84 Yea 1984 29.09.60 Hey 66 Vinyl Worked before I960 acute medical problems. Death cert If lid Staten cause of death cardlo-puleoust jr arrest secondary to angiosarcoma ot Febr I cation with US 1Iver. High PI ent May 66 Aug 70 Air Force t United Letter of 13.07.86 from John E tiiel of Psntasote ulth lettet of 24.02.8t> I rum Dr Aueibach, Patfculoglbi. Utility Wool Resin Dye ra Operator and (Inc JuL 66 Okanlte - Sep 67 Reactor Ope rator) Sep 70-82 Operator 1982-8 1 Ml 1 I Operator, Calendar Shop, uiit I I i et f | eecikt Peg* 32 USA Sheet 8 UPX/ASL2 LAMj iOCA^t > IC1 CHEMICALS A POLYMERS I OK by*tee ot datee LIVER Angioearcoae Caere - (Review bate: I Jiruiarjr 11*8V) l)AY - MONTH - TEAK COUNTRY AND REPKRIMCR USA AO 41 PATE OP INITIALS BIRTH COMPANY PP Cllaer 2AW0.U RFC R Buckler 2.02.13 Goodyear PACTORT Louie* villa Hlegere Fell* Pint vc 22.03.42 1949 10 YE AS OP OATt OP ACE AT EXPOSURE YEARS OF BMCNDBIS OU0MBIS TO EXPOSURE MACHOS! S OATS OP DEATH 19B7 22 A) 03.01.8? 19B7 72 27 20.08.8/ I 13 I !4 15 _L HISTD* | I j LOGICAL |ESTIMATEDl lOTHER CONFIRM*!EXPOSURE (OCCUPATION |CAREER ATEON |LEVEL | 1 HIGHLIGHTS OTHER COMMENTS Ye* JIL II | High | Cheat cel Letter tro |1942-l9/A|Hrker 10.3.8/ | |)942~45 Ur bleu, ftIC, I Low | |I9IS*192A|Foreaaa | |1963*26 _________ i____________ i------------------- _L II Nigh |1949~63 |Retired lOieaicel Op/ 1977 |Shift Sup/ | (Age62) Iforeuii, | (PVC Reeln | (Production | Hedlta 11965*77 | INF Pleat j Letter* fro* Prof Teohuxro University ot Loulevlile, 198/ end Or C A Johneon, Goodyear, 1906 (Left PVC eree lor 6 eonthi la 1965! I ____________ I_________________ !___________ V6 T0 T0 Page YUGOSLAVIA LCI CHEMICALS A POLYMERS LIVER AngloaarcM* Caaea (Review Dale; I Jan 1RR) WX/ASL - LANC|OLA:>t;>, H country and NAME OR DATS Ofl REFERENCE INITIALS! BIRTH I COWANT YUGOSLAVIA 01 02 03 I 0S.O4.14|Jio | Viol I I _______J______ IS.11.311Jugo iVInil I i I 2l.l2.1lMu*o |Vlall . .. I_______ 11.04.301 Juro iVloll 10 11 12 TEARS OF FIRST VC| DATA OF ACE AT EXPOSURE TEARS OFi FACTORY i REFORMER | DIAGNOSIS OlACNOSISi TO EXPOSURE, DIACNOSISl IH1STO- DATE OF |LOGICAL MATH | CONTI SH- (ATION X ESTIMATED| EXPOSURE (OCCUPATION LEVEL | OTHER CAREER HIGHLIGHTS OTHER COMMENTS _______ I_______ ________ I_________ I Sfiu Split I OO.OO.S3IOR.OA.73 I I 1I 00.00.SOI 12.07.73 I I I SR A2 20 20 OB.04.73 | Yea I 23 IS 12.07.73 | Tae I I I I X I | VOf (Production I I I SARIC el at paper Env Health Perspective Vul pp lttR-192 19/A _L *1A him lellec ol 1 0.1 19/8, 111 Vino. ..1 NIOSH changed tlie atatua at Cave 07 tu Vt M production eaptojree. Di Splrtaa a)u notified a new Caee 01 aLao a VCH pteJu* tiu. worker. Spilt SpUt 04.04. S4|11.01.7A I 1 I 1S.I2.SRI03.0R.7R AS 22 22 11.01.74 I 20 03.OR.7R | Tea j_____________ I | VCH |Product Ion J___________ Ruae Raulnakl letter of IV June J9RO a**d IARC letter ot 1 Apt 11 1962 CMA 0 1 0 1 9 7 4 Page 34 TABLE 1 {Review Date - 1 Jan 1989) Incidence of ASL Cases Per Annum fly date of death 1955 .. 6. 7 .j 8 .. 9 .. I960 .. 1 .. 2 .. 3 .. 4 .. 5. 6 .. 7 .. 8 .. 9 .. 1970 .. I .. 2 .. 3. 4 .. 5. 6 .. 7. 8. 9. 1980 .. 1. 2. 3. 4 . 5 .. 6 .. 7. 8 .. Total .1 .0 .1 .0 .0 .0 .1 .1 .0 .2 .0 .0 .1 .5 .3 .2 .3 .5 .8 .5 .11 .11 .9 .10 .5 .10 .5 .3 .10 .7 .6 .5 .3 .4 1~37 \ N.B. CHA i0,9o 1 Does not include Italian 01 but does include German 03. 2 The 1977 total Includes US case 24 which is a Choiangiosarcoma. 3 Does not include the following who are still alive, so far as known: Frl5, 22, 23 4 24, C31 4 32, US33 4 3(>. Page 35 Distribution of ASL Cases by Country TABLE USA W Germany France UK Canada Sweden Italy Yugoslavia Japan Czechoslovakia Belgium Norway 38 ** * 31 ** *** 25 *** 15 13 5 **** 6* 4 ***** 3 2 2 (Review Date - 1 Jan 1989) Total 1^5 * Omit ItOl - atypical case of PVC bag extruder. ** Includes G03 aerosol can filler. *** Includes case US 24 which was diagnosed as Cholangiosarcoma; & Frl5, 22, 23 & 24, G31 & 32, US33 4 36, who are still alive, so far as known. **** Includes one monomer worker. ***** Includes two monomer workers. 1 *e Western Europe North America Rest of World CHft 010199 WPX/ASL2 - LANGIOCASES,10 Total 85 51 9 145 Pag* 36 Pattern of ASL Cases by Factory TABLE 3 (Review Date - l Jan 1989) (a) W Europe Of the 85 caseB| In W Europe, 73 have occurred in clusters at 12 factories. Of the 31 German cases, 28 have occurred In clusters at 4 factories. ASL Cases Dynamlt, ^rolsdorf, Germany 12 BP, B*K7*`UK 11 o 3r Uaclter, Burghausen, Germany 9 > Atochem (formerly Chloe Chlmie, formerly RP), St Fons, France 9 Atochem (formerly PCUK) Brignoud, France 8 Kemanord, Sundsvall, Sweden o M CWH, Marl, Germany o o ICI, Hi11house, UK Solvay, Tsvaux, France 5 4 4 4 Lonza, Waldshut, Germany 3 Solvay, Jemeppe, Belgium 2 Atochem, St Auban, France _2 73 NB: There are 32 pre 1962 PVC plants in W Europe; 19 of these have had ASL cases (Ref Table 8) (b) N America Of the 51 cases In N America, 42 have occurred at four factories out of a total of 55 factories. In N America 42 plants have not had ASL cases. ASL Cases BFG, Louisville, US BFG, Shawlnigan, Canada UCC, S Charleston, US Goodyear, Niagara Falls, US 15 12 10 _5 42 NB: There are 29 pre 1962 PVC plants in N America; 13 of these have had ASL cases (Ref Tables 9 6 10) (c) Rest of World The 9 ASL cases are believed to be in one cluster of 4 and two clusters of 2 cases. WPX/ASL2 - LANGIOCASES.il m Page 37 TABLE 4A (Review Date - 1 Jan 1989) Latency Periods (Years from first Exposure to Diagnosis) W Europe Country ) Belgium No of Cases 2 France 25 Total Years 35 689 Average 17.5 27.56 * ! 0 l0 2 0 t Germany 31 632 20.38 * Italy 6 127 21.16 Norway 1 22 22 Sweden 5 122 24.5 N America UK 15 350 23.33 * 85 1977 23.25 W Europe Average US 38 993 26.13 * Rest of World Canada 13 314 24.15 * 51 1307 25.62 N America Average Czechoslovakia 2 30 15.0 Japan 3 59 19.66 Summary Yugoslavia 4 9 85 21.2 174 19.33 Rest of World Average W Europe 85 1977 23.25 N America 51 1307 25.62 Rest of World 9 145 174 3458 19.33 23.84 * World Average * Of the countries with 10 cases, France, USA & Canada have an average latency period above world average; Germany & UK below world average. 1 m V t * r*v Page 38 DISTRIBUTION OF LATENCY PERIODS TABLE 4B (Review Date - 1 Jan 1989) [ l i t 1 1 1 1 11 [ i l ! 1 l 11 | 0-9 yrs i 10-14 yrs 1 15-19 yra | 20-24 yrs | 25-29 yrs | 30-34 yrs 1 35+ yrs | i Total 1 i 1 1 1 1 1 11 t 1 1 1 1 1 1 11 1 I 1 1 1 1 1 11 Belgium Canada i 1 1 It 41 i 31 21 J 1 1 1 5| 1 i 21 1 11 11 1I 2 11 2 13 1 Czechoslovakia l 1 France 1 1 l| 1 1| 1t 1 4| 1 1 1 3i I 1 ( 9i 31 11 11 2 1t 3 i i 25 Germany Italy Japan Norway Sweden 1 1 1 1 1 t 41 i 1 1 11 il 5| I 9| i 10* | 1 5| i 2 i i 2| 2I 21 il i1 i 1 Li 2| 1 1 1 11 i i i 1I i iI l l I i i 21 i 21 11 11 11 31 11 11 6 11 11 3 11 11 1 11 11 5 i UK t i 11 11 1 5| 1| 5( 31 11 15 USA Yugoslavia i i i i t1l11 11 i 2| 7| 9| 8| 5 i 1 I i il 7 11 Ij 38 i i i 4 I i 1 11 4 i i i i 1 i 1 11 TOTAL ii iii t 12 | i 33 ( 1 37 | i 33 | 1 11 15 1 14 || 145 i i 1 1 1 1 1 11 1 | Average | Latency I, Period | (Table 4A) 1 | 17.5 1 I 24.15 1 l 15,0 1 i 27.56 1 I 20.38 j i 21.16 1 | 19.66 \ \ 22 1 I 24.5 | 23.33 L | 26.13 l I 21.2 1 1 I 23.84 I * Includes G 03 aerosol can filler WPX/ASL2 - LANGIOCASES,13 CHA 010202 TABLE 4C Page 39 (Review date 1 January 1989) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE I MAX POSSIBLE | YEAR OF 1 LATENCY PERIOD 1 ARITHMETIC MEAN 1 1 | LATENCY PERTOD | FIRST EXPOSURE 1 (NO OF YEARS) 1 OF LATENCY PERIODS 1 11 11 | 49 I 1939 1 38* i 1 1 48 I 1940 1 1 289 = 36.12 1 1 97 I 1 1 37,21,37,41 18 1 I 46 1 2 1 32,38,45 1 1 1 45 I 3 1 38,14,32,42,45*** 1 1 I 4 1 28,11,24,20,24,34,39, 1 886 28.58 1 1 1 44*** 1 31 1 1 5 1 27,22,28,29,37 1 1 1 6 1 21,29,31,26,28,15,23, 1 1 1 1 30,35 I 1 1 41 | 7 1 29,24,29,28 1 1 | 40 1 8 1 28,24,34 1 1 I 9 1 30,26,20,38 1 559 25.41 1 I 1950 1 26,22,31,19,23,14,33 1 22 1 I 1 1 19,28,17,28,34,29 1 1 1 36 1 2 1 21**,15 1 1 1 35 1 3 1 25,22,23,22,20,31,22, 1 1 I 1 32*** 1 1 1 4 1 21,21,25,25,21,28***, 1 I 1 1 22 1 849 22.94 1 | 5 1 22,23,24,14,19,21,27 1 ~f! 1 1 1 27*** 24,28,30*** 1 1 1 6 1 21,12,27***,32 1 1 1 31 | 7 1 19,17,15,13,16,28,30 1 1 | 30 1 8 1 18,18,15,17,20,29***28 1 1 9 1 16,21,25,27 I 598 19.29 1 | 1960 1 13,18,21,25,24,25 1 "5T 1 I 1 1 15,16,16,16,19,19,12 1 1 1 26 1 2 1 13,18,17,12,18,21,26 1 1 1 is I 3 I 16,17,20,21,25 1 1 1 4 1 16,17 1 5 1 11,19,20 1 246 1 ~TZ 17.57 I 1 1 6 1 9,18,21 1 1 1 21 1 ^ 1 16 1 1 | 20 1 8 I 18 1 1 | 9 1 13 1 31 15.5 1 1 1970 11 1 1 1 1 VIOLA r 1 16 1 2 1 1 15 1 3 1 1 41 1i 1 i MALTONI 1 i GOODRICH I TOTAL 1 145 CASES 1 3458 - 23.84 i 11 1 --ET5 i * Cholangiosarcoma ** Aerosol can filler *** The following are still alive so far as known Frl5, 22, 23 & 24, G31 and 32, US33 and 36 010203 WPX/ASL2 - LANGI0CA5ES,14 < % O TABLE 4D ?age 4Q (Review dace L January 1989) LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRaphtgat LOCATION ~-- ---------- MAX POSSIBLE 1 YEAR OF I LATENCY PERIOD 1 FIRST EXPOSURE I LATENCY PERIODS IN WESTERN EUROPE I NORTH AMERICA 1 49 1 48 1 47 1 46 I 45 1 1 ! 1 41 1 40 1 1 1 1 36 1 35 1 1 1 1 1 31 1 30 1 1 I 1 26 1 25 1 1 1 1939 1940 1 2 3 4 5 6 7 8 9 1950 1 2 3 4 5 6 7 8 9 1960 1 2 3 4 5 1 1 I 38* 1 1 37,41 1 21,37 1 1 32,38,45 | 38,45*** I 14,32,42 1 28,44*** 1 11,24,20,24,34,39 1 27 1 22,28,29,37 I 21,29,31,33 I 26,28,15,23,30,35 1 29 1 24,29,28 1 28,34 1 24 1 30,26 1 20,38 1 26,22,31 1 19 1 19,28,34,29, 1 17,28 1 21** ! 15 1 25,22,22,32*^ i 23,31 1 21,21,25,25 1 21,28*** | 22,23,24,27***24,28 1 14,19,21,27 | 30*** I 21,12,32 1 27*** | 19,17,15,13 28 1 30- 1 18,18,29***2$ I i5 t 16,21,25,27, I 13,18,21,25,25 1 24 | 15,16,16,16,19,19 1 12 1 13.18,17.18.21.26 1 12 1 16,17,21,25 1 20 1 16 1 17 1 U,19 1 6 1 9,18,21 21 1 7 1 16 20 1 8 1 18 1 9 1 13 1 VIOLA 1970 1 1 12 | MALTONI 3 _L TOTAL CASES 1 I 1 1 85 1 51 1 ROW 1 1 1 1 1 1 1 1 1 1 1 1 1 1 23,14 1 1 1 22,20 1 22 1 1 1 1 16 1 17,20 1 1 1 1 I 1 1 20 1 1 1 1 1 | 1 1 I9 * Cholangiosareowe ** Aerosol can filler *** The-following are still alive, so far as known Frl5 22, 23 & 24, G3l and 32, US33 and 36 WPX/ASL2 - LANGIOCASES,15 010204 Page 41 TABLE 4 (Review dace 1 January 1989) PLANT 1i I START i I UP i I DATE i LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES) 1I I NO OF | I CASES | I1 AVERAGE LATENCY PERIOD | | 1i 11 Ii 11 LOUISVILLE I 1940? i 12,14,15,19,19,20,24,27,28,28,28,29,29 1 15 | 24.53 yearsl USA 1 i 31,45 11 TROISDORF 11 I 1954 1 12,13,16,16,18,19,19,21,23,25,28,29 1 12 1 19.91 | W GERMANY i i 11 1 SHAWINIGAN t 1943 1 11,12,14,21,22,23,24,24,26,28,42,37 | 12 | 23.66 | CANADA 1(1941?) i 11 BARRY 11 | 1948 1 9,17,18,28,31,33,18,19,18,21,32 1 111 22.18 | UK i i 1\ S CHARLESTON I 1939? i 24,30,32,32,34,35,37,38,38,39, 11 || 1 10 | 33.99 | USA i i 11 ii 11 WPX/ASL2 - LANGIOCASES,16 CMA 010205 Page 42 (Review dace l January 1.989) TABLE 4F LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (IQ OR MORE CASES) YEAR OF^FIRST | LOUISVILLE 1 TROISDORF I SHAWINIGAN | BARRY EXPOSURE 1 USA 1 W GERMANY 1 CANADA 1 UK 1939 1 11 1940 1 11 11 1 21 1 21 11 31 1 14,42 1 4 1 20 1 11,24 1 5 1 28,29,27 1 22,37 I 61 1 26,28 1 7 1 29.28 1 24 1 8 1 24 11 91 11 1950 1 19 1 | 31,33 11 I 29 1 I 28 2 1 15 11 3 1 31 1 23 I 4 | 28 1 21,25 1 5 1 14,19 1 23,28 1 1 6I 1 12 1 I 32 71 1 13 1 1 8l 1 91 11 1960 1 11 11 I 16,16,19,19, 1 12 1 2 1 12 1 18 1 1 18 31 1 1 17 41 11 51 61 1 1 19 1 1 9,18,21 71 81 11 1 1 18 91 11 1970 1 11 11 11 21 11 | S CHARLESTON 1 USA 1 38 1 1 37 1 32,38 1 32 1 24,34,39 1 1 30,35 1 1 1 1 1 I 1 1 1 1 1 1 1 1 | 1 1 1 1 1 1 ! 1 1 1 1 WPX/ASL2 - LANGIOCASES, 17 Ciirt 010206 Page 43 TABLE 4G (Review dace [ January 1989) PLANT 1 START-UP DATE 1 i BURGHAUSEN l_ W GERMANY f 1933 ST FONS t I 1939 FRANCE 1 BRIGNOUD 1 | 1950 FRANCE 1 1 SUNDSVALL | 1945 SWEDEN 1 1 NIAGARA FALLS 1947 USA 1 1 SPLIT 1 YUGOSLAVIA! 1950 1 MARL 1 W GERMANY | 1948 TAVAUX 1 1 1953 FRANCE 1 1 HILLHOUSE | 1940 UK 1 1 |LATENCY PERIOD OF ASL CASES | |IN SPECIFIC PLANTS(4-9 CASES)| 11 1 17,21,22,25,24,13,21,32,30 1 11 1 21,28,29,37,38,27,41,34,44 1 I1 | 11,16,18,26,30,25,34,45 I | 1 11 ] 1 | 16,19,27,29,31 1 1 1 1 15,17,21,23,38 1 ! 1 I 20,20,22,23 1 | 1 | 15,16,22,21 1 1 | 19,16,21,26 1 1 I 1 I 1 I 28,25,28,25 1 I 1 1 1 NO OF CASES 9 9 8 5 5 4 4 4 4 AVERAGE PERIOD 22.77 years 33.22 25.62 24.4 22.8 21.25 18.5 20.5 26.5 F WPX/ASL2 - LANGIOCASES,18 CW* 010207 Page 44 TABLE AH (Review date 1 January 1989) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (A-9 CASES) 1 YEAR OF iBURGHAUSENl ST FONS> first exposure! w Germany! France < i!__________________________ ____ 1L 1939 | `71? | !.r.t ' 1940 11 1 37,41 21 1 31 1 38 41 1 44 51 6t 1 | 29 71 1 81 l 28,34 91 1 1950 1 1 11 1 21 1 3 125,32 | 4 121 I 5 122,24,30 | 27 61 1 21 7 1 17 I 81 1 9 1960 1 121 1 I l1 1 21 31 1 1 41 51 1 t 61 71 81 9 113 1 1 1 I 1970 1 1 !1 21 1 1 1 *Monomer worker 1 BRIGNOUDl FRANCE I 1 1 ( 1 1 45 1 1 t 1 1 1 26,30 1 1 34 1 1 1 1 1 1 1 18 1 16,25 1 1 1 1 1 1 11 1 1 1 1 1 1 t i 1 SUNDSVALL 1 SWEDEN | | 1 1 1 1 1 1 27* I 31 t 29 1 1 I 1 19 1 1 1 1 ) 1 1 1 l 1 1 1 16 1 1 1 1 t 1 1 i `i 1 NIAGARA | FALLS | USA I 15,23 38 1 17 l f 21 1 SPLIT 1 MARL 1 YUGO- IW GERMANY) SLAVIA I | TAVAUX FRANCE 11 11 11 1) 11 11 11 1l t1 11 1 23* 1 1 1 1l 1 20 | 22 22* 1 1 1 1 11 11 1 1 19 20 1 1 t1 11 115,16 1 | 21 1 26 1 1 16,21 1t 11 11 11 11 i1 11 l 11 t1 1 HILLHOUSE 1 UK ! 1 1 1 1 1 1 1 28 1 1 1 l 1 1 1 1 1 I 25 1 1 1 28 1 1 1 1 1 1 25 t 1 1 1 1 1 t 1 1 CMA 0 1 0 2 0 8 Page 45 TABLE 5 (Review Date - 1 Jan 1989) 1 Annual Incidence of ASL Cases (Date of Death) by Geographical Area CMA 0 1 0 2 0 9 1955 1 1961 2 4 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 1985 T553 1985 liras 1987 1988 TOTAL 1 Wet|*`ijurope 1 | North America 1 1 |1 1 I1 | 11 1 |1 1 |1 11 1 1 11 15 12 11 |1 11 14 12 I1 1i 14 I3 I6 |6 12 14 13 16 i3 I7 |5 12 | 16 l5 14 1o 11 17 12 i3 15 12 15 i 14 j1 t t3 t4 1 1 79* ** I 49** Rest of World Annual Total 1 1 1 1 12 1 5 3 2 3 5 38 -5 1 11 2 11 9 1 -f -I -, I I 10 5 10 5 3 10 7 16 5 3 4 9 137 | Cumulative 1 1 I Total I Key Events 11 I1 1 12 t 13 1 i4 1 16 1 |7 1 1 12 1 t 15 1 1 17 | Viola 1 20 1 1 25 1 | 33 | Maltonl I 38 l Goodrich 1 49 1 1 60 1 1 69 1 1 79 1 I 84 1 | 94 1 | 99 1 | 102 1 ( 112 1 1 119 1 1 125 1 i TJ5 1 | 133 1 1 137 1 11 * Includes GO3 aerosol can filler but omits It 01 bag extruder ** Does not Include the following who are still alive, so far as known: Frl5 22, 23 & 24, G31 & 32, US33 & 36 Page -to TABLE 6 (Review date 1 January 1939) ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING It.Ol) KEY EVENTS Viola Maltoni Goodrich - 1955 6 7 3 9 1960 1 2 3 4 5 6 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 3 4 5 6 7 8 | WESTERN EUROPE 1 I NORTH AMERICA 1 | REST OF WORLD 11 11 1 Cl 1 1 | C2 1 1 11 1I 1 i use 1 1 1 C3 1 1 I US5 1 1 Cz2 11 11 1 FI 1 I C4 ,C5,US4,US7,US10 1 1 ! Gl 1 Swl I US12.US16 | USU 1 1 I G2 | N1 ,Sw2,UKl,It2 | G3** 1 C6.US2 1 C7 | C8.US1.US3.US23 1 1 1 Y1 ,Y2,Czl 1 G4.G5.UK3 I F2,F3,G6,G7,G8,U3 I C9.USI3 1 US6,US9,US18,US26 1 1 Japl 1 Bl,F4,F5,F6,F7,Sw3 1 F8,F9,G10,Gll,G12,Sw4 1 US19,US20,US22, I C10,US21,US24* I Jap2,Y3 1 | F10,FI 1,G9,G13,G15 I US27.US28 1 Y4 1 G16.G17 1 1 I F12,F13,UK4,UK5,G18 1 1 1 UK6, UK7,G19,Sw5,G20,G21US | US17, US29, US30.US32I I It4,F14,UK8,G22,G23 1 1 G26 1 US31.C12 | UK09,It5,F17,B2,G24,G25,G30| US35, US34, US38 1 1 1 1 UK10, F16, F18, G27.G29 I UK11, UK12,F19,F20,G28 I F21,UK13,Xt6,lt7 | US37.US39 1 | Cll 1 1 Jap3 1 | US40.US41 ,C13 1 I F25,UK14,UK15,UK16 1 1 * Cholangiosarcoma ** Aerosol can filler *** Does not include the following who are still alive, so far as known: Frl5, 22, 23 4 24, G31 4 32, US33 4 36 010210 WPX/ASL2 - LANGI0CASES.21 Page 47 (Review date I January L989) TABLE 7 ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND'GEOGRAPHICAL LOCATION (EXCLUDING It.01) KEY 1 EVENTS 1 1 | WESTERN EUROPE I NORTH AMERICA 1 1 REST OF WORLD| 11 1 1I I 1 1939 1 1 US24* 1 1 40 I 1 1 1 |Frl1,Frl6 1 C3.US27 1 1 21 I 3 |Frl4 ,Fr24*** 1 4 |UKl,Fr23*** 1 US13, US29.US40 1 I C2,US19.C11 1 1 Cl ,C5,US5,US7,US28,US35 1 1 5 I Sw2 1 C4,US3,US9,C12 1 1 6 IFrl,Fr3,Sw4 I C7,C9,US8,US11,US21,US31 1 1 7 I Sw3 1 8 IFr9, Frl7 1 9 IFrl2,Fr4 1 C6.US22.US26 1 US1 I US12.US41 1 1 1 I 50 |Fr7,N1,UK8,UK9 I US16 IY2, Cz2 1 l ISwl,UK5,Fr20,G30 1 US10, US32 I 1 2 IG3** 1 US4 I 1 3 |G15,It3,G26,G31*** 1 CIO, US37 1 4 IG7,G8,UK4,G19 1 US18.US33*** 1Japl.Yl IY3 1 5 IG11,G16,G18, Frl5*** 1 US2,US17,US20,US34, 1 1 |G23,G28,G32*** 1 6 |FRIO,G1,UK15 | US36*** 1 1 1 7 |Fr8,G4,It2,G2,UK12 | C13 1 Cz 1 1 S |Fr6,Bl,Fr22***,It7 1 US23 1Jap2,Y4 1 9 |Fr2,It4,Frl9,Fr21 1 1 60 |G5,G13,G25,G28,It6 1 US39 1 1 |G9,G10,G12,G17,G20,G22 1 C8 1 2 |G6,UK6,G21,B2,G29,Fr25 I US6 1 1 1 1 3 IFrl3, UK7,Frl8,UK16 I US38 1 4 I Sw5 | US30 1 1 1 5 IFr5,UK11 1 Jap3 1 6 |UK3, UK10,UK14 1 1 7 I It5 1 8 IUK13 1 9 IG24 1 1 1 Viola | Jo J________________________ 1 11 \\tJt 1 1 11 11 1 Maltoni I 1 1.1 11 Total|85 1 51 1 19 1 _______ !____________________________ 1 * Cholangiosarcoma (US24) ** Aerosol can filler (G3) *** Frl5, 22, 23 & 24, G31 & 32, US33 & 36 are still alive, so far as known CMA 010211 WPX/ASL2 - LANGIOCASES,2 2 r Page 48 WFX/ASL2 LANGIOCASES,23 (Review date 1 Jamary L989) TJMF. 8 WESTERN EURDfE PVC PRODUCERS - START-UP MEES vs ASL CASS (CMITTING 003 & It.01) |START-UP1 COUNTRY NAME | COMPANY NAME | YEAR 1 1 | 1931 |Wesc Germany | BASF | 1933 I West Germany IWadcer I LOCATION 1 | Ludwigshafen iBurgbaussi 1 ASL CASE NWBEE | YEAR OF 1 | 1st Exposure 11 104,07,11,15,23,24 157,54,55,53,55,69,60,531 1 | 1938 1 Italy 1 | (-toneecatini 1 1 Acna 125,31,32 1 155 1 I 1939 I France I Rhone-ftaulenc/ ISC Fens 103,09,10,11,14 146,48,56,41,43, 1 IChloe/Atochem 1 115,16,17,23 | 1940 |United KingdoralICI/EVC Iftmoom (Closed 1948) 155,41,48,44 1 llhited Kingdom! ICI/EVC IHiUhame 101,04,12,16 144,54,57,63 1 19^5" I Sued IKemanord/Nbbel |Sundsvall(Stodcvik)101,02,03,04,05 151,45,47,46,64 1 1946 1 France IRhone-ftjulenc 1 Roussillon |01 146 | 1948 llhited Kingdom!BP Chen/ICI/EVC|Barry |03,05,06,07,08,09|66,51,62,63,50,50 11 IWeat Germany ICWH/lhls 1 |Marl 110,11,13,14,15 166,65,68,66,56 109,10,26,29 161,61,53,62 1 1949 I Belgium I 1950 |France 1Solvay IJaieppe IPCUK/Atochem IBrlgnoud 101,02 158,62 102,04,05.06,12,19159,49,65,58,49,59, I1 I 120,24 151.43 I France Ithcne-Foulenc/ I Sc Auboi 107,22 150,58 1 |Holland 1 Norway 1 1951 |Switzerland I 1952 | Italy |Chloe/Atochae |Shell | Norsk |Lonza/ ICl/EVC I Montedison/ 1 lltemis, Rotterdam IHeroya, Porsgrum ISlna iTemi 1 101 1 107 1 1 150 | 158 1 IMoplefan 1 1I 1 Italy 1 1953 |Austria IMontedison/EVC (Porto Marj^jera lHalvic/Solvay |Hallain 102,06 1 157,60 1 1 France 1 Italy ISolvay 1Solvay ITavaux | Ferrara 108,13,18,25 |03 157,63,63,62 153 I Spain |Rio Rodano iHernanl 1 1 llhited Kingdom|HXL/BIP/N3RSK. lAycliffe IWeat Germany Iffeediat IGendorf | 1954 |West Germany | Dynast,t iTroisdor? 11 713 155 101,02,08,12,16,17 156,57,54,61,55,61, 1 1 1955 I Spain | 195& |Spain 11 | Monsanto Iberiai|Monzon ICalqsa ISablnardgo 119,20.21,22.27.x 154,61,62.61,55,51 11 11 IHlapevic/Solvsv'ITorrelavega | 1958 IVfeac Gtawy 1 Solvay Iftielnbetg 1 1960 lltatft IS C Ravenna/EVC]Ravenna IWeat Genaviy | Lonza/ICI/EVC IWaldstut 1 1 |64 106,13,28 1 1 159 162,60,60 I -t9^1 1Italy 1 1962 llbrtwal I 1965 1 France 1 Italy iMontediaon/EVC I Brindisi Idles IOporto 1 Rhone-foulenc iMontlucon Ifozzl IFerrandina I 1 121 1 1 1 159 1 (Italy IPenaac IWeat Qermany IWadcer 1 1966 IVfest Germany iHoechst l"i55T IFrance lAtochem I Spain |Rio Rodano 1 Greece lEsao Pappas l--1588" iBelglue IBadipiiil | 1<&9 llhited KingdanlVinatex/Norak 1 Italy Iftmanica/EVC IMira, Venice 105 ICologne 1 | foapsack(Frarkfurt] 105* IBalan I (Miranda de Ebro 1 IDiavata Salonika 1 |Antwerp 1 IStaveley 1 |Cagliari Sardina 1 167 1 160 1 1 1 1 1 1 cm Contimed Table 8 - Continued tESHIN EUROPE PVC PRODUCERS - START UP DATES vs A3, CASES (CMTITPC G03 & It,01) | STAKT-UPI ODUNTEY E | OCMPANY NWE | ICCAXICN I YEAR 1 | 1970 I Italy 1 ism 1 | Porto Torres Sar HirLted Kingicn i ici/evc Iftmoom | 1971 1 Spain 1 Sweden IHispavic/Solvay|Martorell IKananoid/Norsk IStenungsund IlMted Kingdom IBP Oiem | 1972 |Finland IPekaua 1 Holland |D31 IBaglan Bay ISvartback IBeek Limbury I 1976 1 France |Soc Art D'vinylIMazingarbe 1 l(CDF) 1 1 1977" ISpain | Monsanto Iberia|Tarragona I 1982 |Vfest Germany IICI/EVC iVoslapp 11 IWIIhelmhaven | ASL CASE MMBER 1 11 11 11 11 11 11 11 11 11 11 11 1I 11 YEAR CF 1st Exposure * Laboratory worker In Research Department WPX/ASL2 - LHCIOCASS.24 010213 CHA Page 5J TABLE 9 (Review date l January 1989) USA PVC PRODUCERS - START-UP DATES vs ASL CASES I START-UP 1 COMPANY NAME LOCATION 1 ASL CASE 1 YEAR OF 1 YEAR 4_ 1 NUMBER 1 1st EXPOSURE I 1939? |*UCC S Charleston 107,13,19,21,24, 144,42,43,46,39, 1 127,28,29,31,35 141,44,42,46,44 1 Dow 1 Midland (made 1 Saran copolymer) | 1 1940? | *BFG Louisville 101,02,03,04,05, 148,55,45,52,44, 1 106,09,16,17,22, 162,45,50,55,47, 1 126,33,34,37,40 147,54.55.53,42 1 1946 I*UCC/Dow Texas City (Partially closed 1977) ! 1947 1 Goodyear Niagara Falls 108,10,11,20,41 146,51,46,55,49 | 1948 I Fireatone/ Pottstown 1 12 149 | Occidental 1 I Uniroyal Painesville I 1 (closed 1975) 1 1 1950 | Monsanto Springfield 132 151 1 (Closed 1975 1 1 1952 | Dow Midland (No PVC since c 1975) 1 BFG Avon Lake 1 18 154 I 1953 " 1 Diamond/BFG I 1954 | General Tire/ ** Deer Park Ashtabula ! lii 156 | DiversiTech (Closed 1984. Reopened 1986 by Vygen) | 1956 1 Air Products Pensacola (Pace) | 1 Atlantic Refining Brooklyn(Closed late 1960s) 1 Borden Leominster (Closed 1984) I Conoco Hebronville (Closed 1975) 1 - 1 BFG Niagara 1 | Great American Fitchburg 123 158 I Plastics | Hooker (Closed 1983) 1 Hicksville (Closed 1980-81) 1 | Pantasote Passaic(Closed 1984) 39 160 | 1957 1 Atlantic Tubing Cranston (Closed 1967) I Tenneco/ Flemington NJ I 30 159 I Occidental (Closed 1985) 1 | 1958 I Keysor Century Saugus, Cal 1 I Air Products Calvert City(Faducah) 38 163 1 I 1960 | BFG (Closed March 1982 Re-opened October 1983) Long Beach, Cal (No PVC now. I 1 Borden Formerly shown as Watson) Illiopolis 1 1 1962 1 ^wmeco/Occidental Burlington NJ 1 | 1963 " 1 Cenoco/Vista Aberdeen, Miss | I Stauffer Long Beach, Cal /Closed 1982) 1 "3)65 | Conoco/01in Assonet, Mass (Closed by Olin 1975) 1 Ethyl Baton Rouge (Closed 1984) | 1966 | Diamond/Georgia Delaware City 1 1 Gulf IGen Tire/Pantasote 1 Mt Pleasant W Va |(Closed 1982) 1 BFG Henry, 111 1 | Stauffer/Formosa Delaware City (Sold to Formosa 1981) I 1967 I Allied/Robintech/ I Georgia Pacific Painesville, ). (No PVC made by Robintech. GP converted to polystyrene) 1 Hooker/Occidental Burlington NJ 1 1 1968 1 Firestone/Occidental Perryville (Closed 1982) | | | | | | I | | | | | | 1 | 1 1 I I | 1 1 1 ChA 010214 WPX/ASL2 - LANGIOCASES.25 Continued Page 51 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES 1 START-UP I I YEAR 1 I 1969 1 1 1 1971 1 1 19'? 2 1 1 1973 1 | 1974 1 1 1 1 1975 1 1 1 1 1 1979 1 1 1 1983 1 1 1986 1 COMPANY NAME 1 1 BEG 1 Goodyear/BFG I Conoco/Vista I Nat Starch | Borden | Atlantic Tubing/ | Tallyrand 1 Shintech 1 Certain-teed I Georgia Pacific/ | Georgia Gulf | Tenneco/Occidental! Firestone/ 1 Occidental 1 Formosa I Vygen ** I LOCATION | ASL CASE 1 NUMBER Pedricktown NJ | Plaquemine I Oklahoma City | Meredosia, 111 1 Springfield | Cranston RI (Closed 1982) Freeport, Tex 1 | Lake Charles | Plaquemine, La I Pasadena, Tex 1 | Addis (formerly shown as Plaquemine) | Point Comfort, Tex| Ashtabula, Ohio I 1 YEAR OF | 1 1st EXPOSURE I 1 1 1 1 1 1 1 1 1 1 I 1 I 1 1 1 * My databank has no information on UCC before 1946 or BFG before 1950 ** Refer to same plant at Ashtabula, bought by Vygen from DiversiTech. NB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. WPX/ASL2 - LANGIOCASES,26 Page 52 (Review dace 1 January 1989) TABLE 10 CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES |START-UP | I YEAR 1 I 1943 1(1941?) 1 1 1 | I 1951 1 I 1957 1 1 I 1966 | 1 1 | 1979 | 1 COMPANY NAME | LOCATION I ASL CASE I 1 NUMBER Goodrich 1 | Shawinigan 1 101,02,03,04,05 (Formerly Gulf) | 106,07,08,09,10 (Formerly Shawinigan Chemicals) 111,12 (Formerly Canadian Resins & Chemicals) 1 11 Monsanto 11 1 La Salle (Closed 1975) 11 Goodrich 11 1 Welland (Niagara) 1 13 11 11 Esso (Imperial Oil) 1 Sarnia 1 11 11 Diamond Shamrock Alb/| Fort Saskatchewan 1 BF Goodrich 1 1 I YEAR OF | 1st EXPOSURE 1 144,43,41,45,44, 147,46,61,46,53 143,45 1 1 1 1 1 i 157 1 1 1 1 1 1 1 | I 1 | | | 1 1 I I 1 I | 1 1 1 1 1 1 I WPX/ASL2 - LANGIOCASES.27 CMA 010216 Page 53 (Review date 1 January 1989) TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES START-UP | COUNTRY NAME I COMPANY NAME YEAR 1 Pre 1939 |East Germany 1941 I Russia 1 |State Company | State Comps 1950 I Yugoslavia IJugo Vinil 1951 I Czechoslovakia |State Comps 1955 |East Germany I State Comps 1956 |Rumania |State Comps 1957 I Poland |State Comps |Rumania I State Comps 1958 1959 1961 1963 1965 1967 1969 1970 1972 1975 1976 1977 11 I Rumania I State Comps 1 Hungary I State Comps I Rumania I State Comps 1 Yugoslavia |0his 1 Bulgaria | State Comps |Poland |State Comps |Russia |State Comps I Rumania I State Comps |Russia |State Comps I Yugoslavia |Vinilplastika I Czechoslovakia |State Comps |Russia |State Comps I Yugoslavia 1 Hip I Rumania I State Comps I LOCATION 1 |Schopau |Vladimir et al I Split |Novaky |Bitterfeldt | Icechim lOsweicim (Dwory) |Tirnaveni ITurda |Risnov |Berente Borsod IBorzesti 1 Skopj e I Varna | Tamow 1 Djerlinsk IRimnicu Vilcea 1 Volgograd I Zadar INeratovice IKalush Area |Pancevo IRimnicu Vilcea | ASL CASE I NUMBER 1 1 101,02,03,04 101,02 1 1 1 1 1 1 1 1 1 1 1 \ 1 1 I 1 1 1 1 1 YEAR OF I 1st Exposure 1 1 153,50,54,58 157,50 1 1 1 1 I 1 1 1 1 1 1 1 1 I 1 1 1 WPX/ASL2 - LANGIOCASES,28 CMA 010217 Page 54 (Review date 1 January 1989) TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES 1 START-UP| I YEAR 1 I 1950 1 1 1 I 1951 1 1 1952 1 1 I 1951 1 1 1 1 1955 1 I 1956 1 1 1 1957 1 1 1 1960 1 1 I 1964 I 1 1966 1 1 1967 1 1 1 1968 1 1 | 1970 1 1 1 1 1 1 1 I 1971 1 1 1973 1 1 1974 1 1 I 1975 1 1 | 19?7 1 COMPANY NAME Chisso Corp Kanegafuchi Kag Tekkosha Mitsui Toatsu Mitsubishi Mon Sumitomo Kag Denki Kagaku Nippon Zeon Toa Gosei Ryo-Nichi Nippon Zeon Nisshin Kagaku Kureha Kasei Shinetsu Kag Denki Kagaku Kanegafuchi Kag Chisso Corp Tokuyama Seksui San Arrow Kagak Sumitomo Kag Ryo-Nichi Shinetsu Kag Chisso Corp Denki Kagaku Kanegafuchi Kag Kawasaki Yuki Mitsui Toatsu Nissan Kagaku Shinetsu Kag Tekkosha As ahi Glass Toyo Soda Central Kagaku Toyo Soda Unknown 1 LOCATION I I Minamata I Osaka ! Sakata 1 Nagoya I Yokkaichi I Kikumoto 1 Shibukawa I Kambara | Tckushima I Uozu | Takoaka I Takeo | Nishiki | Naoetsu I Ohmi | Takasago I Chiba I Tokuyama I Tokuyama I Chiba | Mizushima | Tokuyama I Mizushima I Goi (Chiba) | Kashima I Kawasaki | Sakai | Chiba | Kashima I Yokkaichi I Hayatsuki | Sakata | Yokkaishi | Kawasaki I Yokkaichi | Kashima I ASL CASE I NUMBER 1 I 02 1 I 01, 03 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 YEAR OF 1 1st EXPOSURE 1 1 58 1 1 53, 65 1 I 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 CMA 010218 WPX/ASL2 - LANGIOCASES,29 Page 55 (Review date 1 January 1989) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS I START-UP | I YEAR 1 I 1953 | 1 1954 | I 1955 | I 1956 | I 1960 I | I 1961 | 1 1965 1 I 1966 | I 1967 | 1 1 1968 | I 1970 | | 1 1971 I 1 1975 | I 1976 | I 1977 | I 1978 | 1 I 1 1979 | COMPANY NAME Monsanto Mexica Policyd Geon Do Brazil Elchlor/Solvay Electrochlor Viplastic Indupa PET Columbiana Carburo De Col Plasticos Omega SOC Paramonga Primex Policasa Petro Dow Polimeroa Mex Rico Chemicals Petroplas Indust Resistoc Huls Brasil Polychem Policyd PET Camacari I LOCATION | I| | Lecheria (Mexico) | I Mexico City (Mexico) | | Sao Paulo (Brazil) | I Sao Caetano (Brazil) | ICapitan Bermudez(Argentina)1 | Mendoz (Argentina) | I Clnco Saltos (Argentina) | | Cartagena (Colombia) | | Medellin (Colombia) | I Mexico | | Paramonga (Peru) | | Puebla (Mexico) | | Managua (Nicaragua) | | Conception (Chile) | | St Martin Puebla (Mexico) | | Guyanilla (Puerto Rico) I | EL Tablazo (Venezuela) | | Tlazcala (Mexico) | | Cubato (Brazil) | I El Salvador | | Coatzacoalcos (Mexico) | I Camacari Bahia (Brazil) | ASL CASE NUMBER 1 YEAR OF | 1 1st EXPOSURE | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 -| 1 1 1 WPX/ASL2 - LANGIOCASES,30 CMA 010219 Page 56 (Review date 1 January 1989) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP DATES START-UP | COMPANY NAME YEAR | 1 Mid 1950s | ICI Australia 1 1960s | B F Goodrich 1 Late 1970s| ICI Australia 1 1 I LOCATION | 11 11 1 Botany, Sydney | 1 | Melbourne I I 1 I Laverton 1 | I Melbourne | 11 ASL CASE NUMBER 1 YEAR OF 1 1st EXPOSURE 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGI0CASES.31 010220 Page 57 (Review date 1 January 1989) TABLE 15 MIDDLE EASTERN PVC PRODUCERS START-UP DATES START-UP 1 COUNTRY NAME DATE 1 I Sept 1986 1 Saudi Arabia ! 1 1 1 1 1 1 COMPANY NAME 1 11 LOCATION 11 | National Plastic |Arabian Petrochemical Company | Company IMadiant | (Ibn Hayan) 1Al-Jubail lAl-Sinahyah 11 11 i1 WPX/ASL2 - LANGI0CASES.32 CMA 010221 J. # t H1H-) 1C I CHEMICALS 4 POLlMtHS LIVER AngioMarc<MM Cases COUNTIV AMD iiruEiice NO HAMA 0 INITIALS DATA Of III1N COMPANY 10 FACTORY FIRST VC YEARS OP RATS OF ACS AT EXPOSURE YEARS OP DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS 12 I) IS _L HISTOLOGICAL ESTIMATED CONFIRMATION EXPOSURE OCCUPATION LEVEL OTHKK CAlittS HICHL1CHTS UTHtS COnHtNTb O ZS > O t* o w M w