Document nmyL202B9eKKwr5k0yJOnYXga

JOHNSON & JOHNSON RESEARCH FOUNDATION New Brunswick N. fice ficefice CTPA Subject R.F. Schwenker G.H. Lord B. Semple G. Hildick ' W. Nashed R. Stites J. Marshall T. H. Shelley L. Kaplan E.R.L. Gaughran T. P. Finkelstein Oesterling Notes from CTFA Pharmacology & Toxicology Committee & Industry Aerosol Safety Committee Joint Meeting- Scottsdale Arizona - January 20 1977 The representative from Palmolive requested that the minutes from the last committee meeting 12/14/76 reflect the fact that his company . is opposed to the inclusion of talc in the proposed CTFA particulate testing program Based on the 1/11/77 letter from G. Lee requested any that this subject be referred to the CTFA Talc Subcommittee before decision is reached ; Dupont will argue for a delay in phase proposal for chlorofluorocarbons . 11 and 12. They believe that ozone depletion estimates are overly pessi- mistic and that a good case can be made based on benefit arguments 3 The outlook for Propellants 22 and 142B as alternatives does not Both have been shown to weak mutagensappear at promising this time be in the Ames assay Dupont has decided not to make them available for use in con- sumer products until the issue has been clarified 4. Methylene chloride has been shown by Stanford Research Institute to be a potent mutagen by the Ames test CTFA Pharmacology & Toxicology Committee to form a task force to review available data on long term safety of hydrocarbons propane butane iso- butane for use as alternative propellant systems CTFA Pharmacology & Toxicology Committee Task Force is preparing a response to FDA's proposed good laboratory practice regulations for non- clinical laboratory facilities Comments to FDA due March 21 1977 Vid Jaly Ell Jaly Ell 0099140 JNJTALC000588961