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IRIS QuickView, IRIS Web Site, US EPA Page 1 of 2 Integrated Risk Information System Recent Additions | Contact Us I Print Version Search: EPA Home> Browse EPA Topics > Human Health > Health Effects > IRIS HorrrelRIS QuickView IRIS QuickView \ : -5 v ^ List of IRIS Substances |Select a Substance Full IRIS Summary QuickView Asbestos (CASRN 1332-21-4) Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the Full IRIS Summary to put this information into complete context. For definitions of terms in the IRIS Web site, refer to the IRIS Glossary. Status of Data for Asbestos____________________________________ File First On-Line: 09/26/1988 Last Significant Revision: 09/26/1988 Category Oral RfD Assessment' Inhalation RfC Assessment Carcinogenicity Assessment Status No data No data On-line Last Revised 07/01/1993 Chronic Health Hazard Assessments for Noncarcinogenic Effects Reference Dose for Chronic Oral Exposure (RfD) Not Assessed under the IRIS Program. Reference Concentration for Chronic Inhalation Exposure (RfC) Not Assessed under the IRIS Program. Carcinogenicity Assessment for Lifetime Exposure _ Weight of Evidence Characterization Weight of Evidence (1986 US EPA Guidelines): A (Human Carcinogen) Weight of Evidence Narrative: Observation of increased mortality and incidence of lung cancer, mesotheliomas and gastrointestinal cancer in occupational!y exposed workers are consistent across investigators and study populations. Animal studies by inhalation in two strains of rats showed similar hrrrv/'cfnuh ena sovtirit/ntiickview cfrrUsubstance nmbr^QjTl 9/22/2002 IRIS QuickView, IRIS Web Site, US EPA Page 2 of 2 iitiutiiys iui luny cancel anu mesuuieiiumas. Ainmai eviuence iui caicmuyeniciiy via inyesuuii is nmiieq ynaia rats leu iiueimeuiaie-ianye chrysotile fibers; i.e., >10 um length, developed benign polyps), and epidemiologic data In this regard are inadequate. This may be a synopsis of the full weight-of-evidence narrative. See Full IRIS Summary Quantitative Estimate of Carcinogenic Risk from Oral Exposure Not Assessed under the IRIS Program. Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure_______ Air Unit Risk(s) Extrapolation Method 2.3 x 1 O'1 per f/mL Additive risk of lung cancer and mesothelioma, using relative risk model for lung cancer and absolute risk model for mesothelioma Air Concentrations at Specified Risk Levels Risk Level Concentration E-4 (l in 10,000) 4x1 O'4 f/mL E-5 (l in 100,000) TxlO'5f/mL E-6 (1 in 1,000,000) 4x10`6 f/mL Dose-Response Data fCarcinooenicitv. Inhalation Exposure) Tumor Type: Lung cancer and mesothelioma Test Species: Human Route: Inhalation, Occupational exposure Reference: Selikoff et al., 1979; Peto etal., 1982; Seidman etal., 1979; Peto, 1980; Finkelstein, 1983 Revision History_______________________ Review Full IRIS Summary for complete Revision History. Synonyms_____________________________ 1332-21-4 Calidria-asbestos Asbestos What's New | Search IRIS I IRIS Homd NCEA Home I ORD Home EPA Home I Privacy and Security Noticd Contact Us Last Updated on URL; http7/cfpub.epa.gov/iris/quickview.cfm?substance_nmbr=0371 httD' ,/cfpub eDa.ov/iriS''quickview.cfm0substance_nmbp=0371 9/22/2002