Document nmKq3Y7BrXZ05adwEg1DxDBL1

m i n u t e s o r the K u m j i c at k z t t z a I kg laboratory - -June 22. # 5 6 . , . . Present: Dr. i U p o n d R. S u s k t n d , K e t t e r i n g Dr. J u lin 7an n , Dr. R. C. W a l l a c e , Monsanto, N i t r o Mr. C. F. L u e c k e , M on sa n to , N i t r o K r. E. L. G o d f r e y , M o n s a n to , N i t r o Kr. E. P. V h e e l e r , M onsanto , S t . Louis K r . P. K. B o w l e s , E l a g x , S t o n e , Maury, Anderson, and Bowles K r . L. C. U e g e r , M onsanto , K i t r o L Dr . S u s k i n d p r e t e r . ; e d t h e g r o u p w i t h c o p i e * o a w r i t t e n r.,,--c a r y o the e x p e rim e n ta l work done a t the K e tte rin g Laboratory during the p a s t s e v e r a l o o n th s. A copy of th is L=.ai-y is a tta c h e d . Dr. S u s k i n d e l a b o r a t e d on t h e work c o v e r e d by t h e r e p o r t arid by sketching a c r o i s - s e c t i o n of the sk in explained to the group how c h l o r - a c n e e f f e c t s t h e h e i r f o l l i c l e end t h e s e b e c e o u s g l a n d . Dr. S u s k in d p o i n t e d o u t t h a t th e p e r c e n t c o n c e n t r a t i o n .and t o t a l dose r e f e r r e d to In the ta b le In h is sunxaary re p r e s e n ts the sample In ea c h c a s e and n o t a c t u a l t r i c h l o r o p b m a t e . I t was n o t p o s s i b l e t o u s e h i g h e r c o n c e n t r a t i o n s o f S o d i u r TCP b e c a u s e o f t b c e x t r e a t i r r i t a t i o n o f t h e s h i n 0 t h a t w h i l e t h e R a l o w a x was a p p l i e d u a 2C1 c o n e e n t r a t i o n t h e M t l r n n c o n c e n t r a t i o n o f a n y o f t h e TCP s a m p l e s was 71 and i n some i n s t a n c e s was h e l d as low as 2 . 5 1 o r 2 .51 end 0.7S1 tr ic h lo r o p h e n o l. ( ' " ----- , ............................. ... . Even ,.io .view: of^.tha, d i f f e r e n c e s in . concentration, Dr.. Suskind ^ 2 found o u r . n o m s l Sodlua T richlorophenat* producing d e f i n i t ^ c h lo r - a c o e . ' The Sodiua T r i c h l o r o p h m a t t p re p a re d from d i s t i l l e d tric h lo r o p h e n o l gave by comparison a e i l d resccio n and with the ex cep tio n o f one s lid e seen from one of the four su b jects used, t h e r e was no e v id e n c e o f a c t u a l c h l o r - a c o e . The r e a c t i o n to the = -* te r la l p r e p a r e d by the Diamond A l k a l i p u r i f i c a t i o n p ro c e ss ( d i l u t i o n , f i l t r a t i o n , and p r e c i p i t a t i o n ) vas le ss marked than the sample p re p a red by d i s t i l l a t i o n . Dr. Suskind in d ic a te d th a t fu tu re work a t K e tte rin g e ig h t extend along sixrilar lin es to further c la rify whether p u rified a te ra is ? ^w r e a c t u a l l y n o n - a c n e g e n i c o r t h a t w o r k n i g h t be u n d e r t a k e n t o ' i ''h ^ n k fo ^ <w. - r *_- `VT - , - - 2- I c t t e n i n e i u : r . c : h t : i r . f c m a i i o r . At w ou l d be c i : r . : e : t $: t o f i o r . u t t o . !>r. S u s k i n c w i l l be cr. v a c a t i o n t h r o u g h t h e --o n t b of J u l y so t b * t no f u r t h e r work could be i n i t i a t e d b e fo re t t n c *>_>*<-T- tin e In Augutt. f t htr. E l m e r V h e e l e r d i s c u s s e d b i s r e c e n t v i l i t w i t h BASF l_n ^ G e r m a n y . Be ( t i l e d t h e e e s s e n t i a l l y e l l t h e p e r t i n e n t i n f o r m a t i o n i s c o n t a i n e d f_n L i s n m o r o d u a end e n p b a s i r e d t h a t t h e -1 p e o p l e s t LASF w e r e v e r y a ru x i ou s t o t i c h t r . g e i c f c r o i l i c r o w i t h , h b r i u o t o c ad K e t t e r i n g on e l l p h a s e s o f t h e p r o b l e m . Re v i s ^ given the impression a t the tid e of his v i s i t th at they were i prepared to exchtoje a ll ir f o n u c io a including process data* b u t t h a t i t was n o t p o s s i b l e a t the m eeting s in c e he d id n o ^ h a v e M o n s a n t o p r o c e s s i n f o r m a t i o n w i t h b i n . I t a p p e a r e d t o ' j >t r. W h e e l e r C h a t t h e s y ^ t o e s a nd c o c p l a i n t s m a n i f e s t e d by . v* t h e w o r k e r s i n t h e German p l a n t p a r a l l e l e d t h e Mons an to e_r- p e r i e n c e , b u t i t v u hi op in ion t h a t German c a se s were p r o b a b l y c o r e s e v e r e . D r . O e t t e l o f B-A5F t e e e d p a r t i c u l a r l y * in t e r e s t e d th a t ths Monsanto cases had also presented o b je c tiv e com plaints sugge s tin g p e rip h e ra l n e u r i t i s . j . ' . -<~Z- I t was ag resd t h a t Mr. V h e e le r w i l l r e q u e s t ap p ro v al from th e O r g e n i c D i v i s i o n f o r e x c h a n g e o f i n f o r m a t i o n w i t h LAST, and i t i s a n tic ip a te d th a t Dr.' Suskind w ill correspond d i r e c t l y w ith Dr. O e t t e l . and t h a t someone a t R itr u w i l l be d e s ig n a te d to c a r r y out the exchange o f such p la n t in fo rm a tio n as is approved. Each p a r ty ccmdue tin g correspondencs w i l l p ro v id e the o th e r p a r t y and the Monsanto M edical Department w ith carbon c o p ie s a l l m a te ria ls sent snd re c e iv e d . I l l htr. Taul Soviet discussed c e r ta in aspects of the chlor-acn_g " c l a i m s Vvov i n l i t i g a t i o n a n d r e v i e w e d f o r D r . S u s k l n d ' s b e n e f i t sene of the o e d ical asp e c ts which hsve been a lleg ed by t h e p h y s i c i a n f o r t h e c l a i m a n t s . The p o s s i b i l i t y o f Dt . S u s k t n d a p p e a rin g as an e x p e rt w itn e s s was d is c u s s e d and i t was a p p a re n t t h a t Dr. Suskind f e e l s t h a t t h e r e was m inim al e v id e n c e o f l i v e r ` d is o r d e r s and in one e s s e , evidence o f nerve damage in people e x a m i n e d i n 1 9 ^ 9 . He s t a t e d t h a t t h e r e was n o s i g n o f s u c h d i s o r d e r s i n any o f 35 p e o p l t w hich th e K e t t e r i n g Croup examined . a t K itro in 1953. Dr. Suskind stro n g ly urged th a t c o n s id e ra t i o n be g i v e n t o p u b l i c a t i o n o f a l l _ o l --r h e u p t r b c n t a l r e s u i t s ^I SL J\ S 3 2 S 0 6 5 ... . T: " Vr -'V S L' S O B G #^ - -- %*.f *tSS?5^k>v.- *v^ y 7t ~ ' . r; .'* . - v. ; ^v ' k '.. ^ --T-. v - .- '? " ' v n ^ .* - l- 7V 3 : 1 . r" Tt Pr ajjcind t eostlet <" _ ''*, ben A C u a O rte l_ to _ _ : *r;*- r'T.V." iY 3-1 V *. -z,? 1 ^ ' ` :-^U~1lj , i ~ `d% ***L; "" - . ; .r r ^ . *- " - - . ' llT r:, T?rt T ir^ n ii * ".-J-`::.-i._ r.orenber IS , 155 E rv * Jli* " ,%j* > S itr in -- *.., .1 : -' ^ -v j*' y ~ *.' y r. ~J7* -' TV***A'* On Howenber 1 7, t . H c d t l n end I accom panied O r. S u a k ia d :-VVV :. o l th e l e t t e r i n g L a b o ra to ry to & t i n e **.t t h i k o rk n a n ' s ..' . Compensation Com aissicn In C harlesto n . _E tp rese n tln g t h t Comaatssloa a t t h i s m eeting w r * th e O ccupational D isease U:SU:.? ' U B oard composed o f D r*. E r ic k , B iern ,* and A lif f ,.lf c r . J a e k -.-a U*- 7 ?.? CantarbcTT, Legel A iris te n t, ltr . E arry B ess o f th e Oc- T :' cu p atio aai D isease D ivision. >'U '"* D ^ B r i c k 'p r e s e n t e d a eopy"o f * r e p o r t by Dr.' E. 7 . 'E = i t h an d O r. B. I . I t l l y a d d re sse d to Mr. . P au l B a ile y d a te d 1950 .'.>'-5: and ask ed D r. Suskind to co n sen t on t h t fin d in g s re p o rte d . ~ ~ y~ Ct . S u sk in d s a i d .t h a t h t I s f a m i l i a r T lth t h t r ^ > o r t r a d " V. 1r c o n c e n ts ! on t h t te c h n iq u e ts p lo y e d r e p o r tin g t h e t D rs . v ' ^ ".r.:v'.-. A dam , Spencer,* end I r i s h tho o rig in a te d th is technique - > using' th t ta r s of ra b b its hare s in e t abandoned i t . le tte r in g L a b o ra to ry h a s a tte m p te d to d u p lic a te to o t o f t h e i r work and ; h a r t found th t s a a t t p i t h t l l a l b y p e rp lts ia and f o l l i c u l i t i s a_s r t p e r t e d , b u t no a e n t i u p ro d u c e d .;. D r. Suskind s t a t e s . *.?. \ th a t i t is no t p o a sib lt to pre-detem nt~ acne genic p ro p e rtie * o f s e a compounds by th is r a o b it t a r t e s t . . - rl -:* . . ^ J.*. . .. D r. B ric k in q u ir e d i f th e re was any d if f tr a n c e h ix to - ' Ur.- c h e m ic a lly betw een acne v u lg a r is and c h lo r - a c n t. .By B it o f d ia g r a m D r. Suskind showed th e e o e p e ris e n o f th e two X ' t y r e s o f t e n t and s t a t e d t h a t h i s t o l o g i c a l l y th e two e r e U U ' ' -- th e s e n t 'r i t e , t h t e x c e o tio n t h a t c h l o r - t c n t l t s i c o s c o n ta in -"-UJ"'- '- 'e rn e rtu t acre free e h n its ttro l. '! : D r. B ie m asked s h a t causes' acn e .' D r. Suskind sa id th a t v*Ty^2*y.r/.- i s t very -large ru e s tio a and t h i t 't h e r e a r t cany th in g * " r u- 1S iiv - .C * y f t - t n ' b c l e r m t l . ; ' E a rre re r,-it i r b t l i e r e i th.*t acne rc L g ^ ric ' . is c in d u c e d .i n ; t h e c a l t b y : t e s t o s t a r m e nd i n th e f e n a le by U 4: ;"Sfr^**i-*iv:*'JL-- n ro g e x te re s a e . -*73M i . o p in io n i s b a te d on* c o n s id e r a b le e x o e r i - r u ^ ? n c n ta l-w o rk w ith an im als b u t. d o e s n o t p re c lu d e t h e e f f e c t o f -tU;.--^ ::r o th e r aD dm genic substances^ C hlor-acnt has onl: b e e n -rro d a c e d e x p t r i m f ^ a l l T S2^ t l e tte r in g 1 ^ stipg . rra L rln c B alorex lO lA '.in ccacentratlon or h u ra n f s r e a m for, one retk ..n r. h d r s . . . f t l i ce ** eanttet lth the sicln eja-parodoce ___ _ the rossibility thet .7 be proaoeed Ler atea i ot rule! 001. -/ * . < ,, .. . .. */; ' "*p**>'-';> ` *.** *" '' ,, ' ' . , *"* D r. Ele exked nhether sfcia reaetia eco be dne t stress :7\ ahenoaena or.fro* t rttr:.OTerlE7 .;;:Er. Soskind .stid be -wouId be tfrtld to hixrrd t..rjess,_bot -work.bs*.beca.done;*t i i ' ' * aell'OnlTerxltyjeltSijfoo&C*aeae Tnlftristetieats s o b j e c t e d *- V | ^'c.to laterrle,`ssttrre-s"'*"*`V''.. f"ieesnreaent o '.sebea, o o tp o t shoetd /lM . V-vvr'-*_'_st_r_e_ss.._._la_c_r__essee ^ o f.a s /w e h es ifiO% ia a c n e ceses-o n ly ;v ia -: ST':;L'-".. oo-eee-cases' tb e 'ln re e s e re s er7 .; lls h t. -fih e th e r 'th X s - ? # J * V \- i. rv ^ /'.ra i i. t rrs .^ -S e .th ta tJcec irb e tn e r th a i : '"fcg te ri J. saica - r e s -d re a v tc Pr-.gqskjod J o r - t e s tl. rr^~.'aa5e byvthe' State^Bepertaentof Sealth r e ad -rbea a*eopj.of theiryrport-coold not'be.forzad,be to . th * S lx t In .' .v;; -- " dos t r ie ! y tie n ix t.-> B e 'V - . - _ V -*.* ' *'-**" t n l t ' I I I . e tso ra b le beca Tea -tbt lxpreslcd_ fie Sf reobeSttd 'tEl totosetie ra th e board e copy oX .the 's a r r e j1.report** > - . ' * i n s jpasted th a t Xoasento -coold be a o rt *:.T*lt:; the 2,1 ,5-T sad spoke'of seeing ecatinooos operetlocas'at the da?cat pleat-. *fr rr-v-*:" * *- Brick also-laferred that each *of.the laforaetioa conceralac the ehlcr-ecne problem bad-at one tlae or*enother bees held .r-fe-i'li :T secret from.the".board 'His-iapressiens on.these t*o-natters H s lo rs x a o S ^ .re p o rte d ^th e t-th e re x ts a rra e tlra -.e r^ c h c B g e ^ ^Eoskladi.thfla described the'-work arlas^lortx 1011-end: '.g^^rrerytaintedi2,*;* 7an-eaiils*aad*dgasy-fie-reoortedss&i ^ t h r t v n * n e a a - '.o r r * t 3 - mx anifeststica bed`been-ladocel.'laiaay' jtk* talnela:byNeither-cf.'tbt-xeteriels/bntwthet oc i t ' akla:eklor-cene.-hadbecayprodaeed xith:."the'.5elocsx,`;bot -there a T5*53 * vr ^ -l-'-' -; n raan at .* iA.-J.*- 2 ' - ' 2TmV4 la e conference continues r i t h conversation d ecline r i t a the o v e r a l l i s c e c t s o f th e e h lo r-a c a e -.-roblen, end F.. E i e n r e t d e x c e rp ts frcra th e t r a n s c r i p t In th e r e c e n t Dewey C arto n h e a r in g f o r D r. S o slctn i* ! b e n e f i t . The n e t t i n g te e n e d t o . be ap p reciated by th e c o c a la sic a e r, * rep resen tativ es,* end i t l a b e lie v e d t h a t e f a v o r a b le im p re ssio n r x i c r e a te d . ;4- . . -. a jj....Bs ooatehwJhoxhtn Mc c rit Clain ic a l' e ad oea I e 'f n ee ts, l th we a t in~viev o f Dr. hoold prepare a `B ric k s * ' fa irly L'.'z X `* 1 ^ erehensive''story o f the e n tir e eh lor-acne s itu a tio n - lc h s h o u ld l a c lo d e n o t o n ly th e e x p e rim e n ta l work done -at M ellon "J- r '~?S end L e tte r in g b u t la w e s tig a tic a u l work done in th e p la n t in co n n ectio n w ith the a u to clav e in c id e n t. " b e lie v e th a t .-r . 7 -7 .t h i hoold be made a v a ila b le to th e O ccu p atio n al /D isease B oard to g e th e r w ith c o p ie s o f any re p o rt w hich we ha ve / i h a t have n o t been wade a n i l a b le to th e n .* ' Such in fo rm a tio n e ta " be c i n a to th e * w ith th e t i p u l a t i o n . t h a t i t i s .f o r t h e i r 4 :V1 .e v a lu a tio n 'o n ly a n d - is n o t to beeome p a r t o f th e p u b lic ^ r e cord 'v-t t * " i t th e end" o f o u r `c o n fe re n c e a t ' t h e 'c o o l s s i an o f f i c e s / ^ Dr^SivL"^ ^ . " ~~Suskind to g e th e r w ith M cC lain-and 1 / d is c u s s e d o u r.p ro b le m w ith M r. P a u l Bowie* _aad M r.' JL. C. S to a t a t t h e i r o f f ic e * Both D r. Soskind and Mri' Stone f a e l t h a t i t would be w ise f o r 7t o fo llo w up on th e l e t t e r i n g r e c o a a a a d a tic n t h a t p e r io d ic a i r - sam pling be made In th e 2 , i , 5-T p l a n t . Both M cClain and I r?_* 'e x p re s s e d d o u b t as t o th e v a lu e o f i n f o r a a t l o n so o b ta in e d :^ - - .vV;' n a le ss I t be u se d .to counter Dr. E a llo ra n 's accu satio n s Me d i s c u s s ed th e f in d i n g s o f D r. E. M estsaan c o n c e rn in g -- psyc^icoeu r o s T r in m ost o f th e eiro lo rees he ha* t u b i r - 5 * 7 M r7~gtone i s a trp re n e a s lv e a* to th e l n a i i c u tlo a * may JbeH ra w n " if t h i s - I s "Subm it te d a* evidence". T h T . D r. S u sk ln d a l l . r e a d a o a r e r which I o b ta in e d f r o S 7 - *: yestnara~C cncerning sene o f "his e v iiu E tio n i on o th e r ^ c tie n t* usiag^ th e C o rn ell Jied lca l Ib d e r, and .Dr, Sgs^-i^d su g g ested ~ lot of-thl*-tree' cfA--- _.r *--*.fc**--*w* ...^ d n ^ S rc h 'o p in io n w . .c sv A cuereauftap=rw fu tu re work th lr b h r ' been o u tlin e d l o r c o n s id e ra tio n 'a t " . 7 L e t t e r i n g L a b o ra to ry ; ws-i r e v l e r e d . v l t h th e .a t t o r n e y s , *nA '' ^ ^ S t c a e . cade_-the .p o i n t ; ; t h a t . 'r f a l l t - . d i r t l l l i n c th e p h e n o l may