Document nm9g6rbOmrM9jaJDdeeRDOVr6

FI 3 e / Destroy ' CD5 ,JTC June 5, 1968 4K.\M Wil " Mr. Wayne Thornburg, Manager Organic Chemistry Research California Packing Corporation Plant Ho. 554 4204 Hollis Street Emeryville, California 94608 Dear Mr. Thornburgt We do not have any subacute oral toxicity on the chlorinated biphenyls, we have, however, serried out a 90-day subacute oral toxicity test on Aroc3oj/lfiOpJa chlorinated terphenyl, on rats. These were fed at 100, 300, and lOOO ppm. The 300 ppm group was entirely negative. The 1000 ppm group showed some change In the liver'to body weight. Microscopic pathology findings in all groups were normal. Tests comprising 18 weeks were carried out with chickens with the same compound at levels of 500, 1000, and 2000 ppm. There seemed to be a drug related effect on mortality on the dose levels of 1000 and 2000 ppm. All our work on chlorinated biphenyl has been either by In halation or by skin absorption because the compounds are not intended to be taken internally. I attach a Hygienic Guide series reprint on the chlorinated diphenyls. The long-term study on inhalation Is No. 3, by J. P. Troon. In addition, I attach a summary of our unpublished data on the chlorinated diphenyls when applied to the skin of rabbits. If you will let me know what your particular planned use of the Aroclors is, I might be more helpful. Sincerely, REK/ln R. Emmet Kelly, M. D Medical Director 087S07 moms UNPUBLISHED DATA 20 Day Subacute Dermal Toxicity to Rabbits Aroclor 1221 LDjo 250 mg/kg/day No adverse effect on body weight, local skin reactions, hematology, urine analysis, or gross or micropathologic findings Aroclor 1242 LD50 75 mg/kg/day Slight adverse effect on body weight at 75 mg/kg/day. None at 50 mg/kg/day No adverse effects locally on skin, hematology, urine analysis, or gross or mioropathologic findings. Aroclor 1268 LD50 1250 mg/kg/day Moderate to severe adverse body weight effects at 1500 and 2000 mgAg/ day. Slight at 1000 and none at 500 mgAg/day. Local skin reaotions were slight erythema, subdermal hemorrhages, drying, wrinkling and fissuring from all doses (500-2000 mgAg/day). There were no adverse effoots on hematology or urine analysis. No gross pathologic effects at 500 or 1000 mg/kg but 1500 and 2000 mg/kg/day produced liver discoloration (lighter). No mioropathologic affects at 500 ox 1000 mgAg/day but moderate hepatic necrosis from the 1500 and 2000 mgAg/day doses. HONS 08790"