Document nm7bg4MRej8K8r8qzZgv5208m
`DuPont
DuPont
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Visit
Visit
MJeuentien3g0M,2in00u0tes
June 30, 2000
IInn AAtttteennddaannccee
DDJouuhpPnooOnn'ttC:onnor, Reproductive and Developmental Toricology
JJJBoooohhhbnnnHGOGoaka'Cnnenon,onoEnnnc,o,otrEE,onnxRvviieicrrpooorlnnoommdgeuyencntttiaavlleFFaaanttede: Developmental Toxicology
.
GBaorbyHJoekpseo,nE,cPohtoaxrimcaoclookgiynetics
GGearrryyJeKpesnonne,dPyh,aDrirnreacctookrinoeftAicpsplied Toxicology
Gerry Kennedy, Director of Applied Toxicology
aS3uMme:: Beach SJJDoouahhennnBHBBeauuaktcteeehnsnhh(ooaftfffbeginning only) DPPNaeaauulnldl HaLLiiaMeekaddereeserrc(kait beginning only) NGeea]rdya OMlasreencki GMMieikkaereySSOaannltstoeornroo
P"PTuuhrreppsootssaeeteoodffpM Muereepetotiisnneggof the meeting was to "clear our mutual understanding of the TppeehrrettiisnntaeentnettdddapatutaarpooonnsPPeFFoOOfAAt.h."e" meeting was to "clear our mutual understanding of the
NeNvooitrdaaenbbteetnnheea::t TTthhhirrsoouuDgguhhPosseenvvteetrreaaallmccoowmmammsecenhntatssrgmmeaadddeewiddtuuhrridinneggvetthhleeommpeieenetagtiinnrgse,,ciiottmbbmeeeccnaadmmaeetion 1e0vibdeepnrte~seantttelddstDobuuPsionnetstselaemadwerass acthDarugPeodnwtriethladtievveeltoopPinFgOaAraencdo,mpmerehnadpast,ion ttoelboemperre-sbeanseteddprtoodbuucstisneassswleealdlers at DuPontrelative to PFOA and, perhaps,
telomer-basedproducts as well.
Agenda TTA1.hhgrreeEenenedvppairr:riiommnaamrreyyntaaarreelaadssafftooar,r ddiinisspccauursstssiiicoounlnawwr,eerbreieoaamggarrgeeneiedfdiuucppaotonin:o:n 2312.... EBBDieniosovpcpierreriorspsnitimsisttveeeennntcctoaeexlaiadcnnaoddtlaott,ghhyieen,iccpunuarprrrrateerinctntuitcluuaunnlr,dadrebe,rirossfmttuaanancngtddniiioninfnggiaclooafftrieeeollpniirmmoiidnnuaactttiiiooonnnhhaallLf-lliiffee
3. Descriptive toxicology, in particular, functional reproduction
The subjects above were taken in the order indicated.
The subjects above were taken in the order indicated.
Then meeting began at approximately 9:15 am and continued through lunch with Taaddhjjeoonuumrrhnemmeeteinnnttgaabtteaagppappnrrooaxxtiiammpaapttreeollxyyim11:33a00tepplymm.9.:15 am and continued through lunch with
33MM CCoonnfiifiddeennttiiaall I
Exhibit 1721
11772211..00000011
SMA0O4e991 1
3MA00469911
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available. As additional information is developed by 3M, it will be submitted.
DuPont did not appear to have any substantial information to contribute and sDhhuaaubddPmnnioosontsttiaadossindyyteenottodEdteePavvpAeepllweooaappsreetddportthohhvaeeivaadenneaaadln,lyyytatiissccuaaplblrsommtmeaeitntshhteoioadddl,ooilbnlooyfgogyGry.em.rarAAtyioccKnooeppntoyynecoodfofyntt.hthreeitbDDuwuutaPePsoaonnntdt soubbvimoiusssifornotmotEhePAsuwmamsaprryovliedveeldi, nafsoprrmoamtiiosneda,nbdycGomermreynKtesnmnaeddye.fIrtowmatshe
obvious from the summary leve! information and comments made from the
cDDouumPPpoolnenttt erredepporrenessPeenFntOtaaAtt.iivveeAssntthheaaxttplloiittsttulleereeerfdlivoviicrrouonmnmemneentnttiaanll taahnneddfeeoccroomttoooxxf wwanoorUrkkEIhhPaaddwbabeseeefnniled
completed on PFOA. An exposure document in the form of an UEIP was filed
w`wiitthh EEPPAAoonn JJuunnee 2266%th..
"T`TThhheeeyDDhuuaPPdoonontbttrraeeippnrreeedsseeanntstaaattmiivpvelesse iiinnnqqtuuhiierreepddasaatbbfoourutotmtthh3eeMa.avvaa3iillMaabbriiellisttyypooonffd1Ce4-dClta-hlbaaebtlaellleseddamPPpFFlOOeAA.. Texhiesytehd;adhoowbetvaeirn,editawsaasmnpolte iinmmtehdeipaatsetlfyroavmai3lMab.le3fMor useresponded that a sample
existed; however, it was not immediately available for use.
BBiiooppeerrsisstiesntceeanancnded tthhee CCuurrrreenntt UUnnddeerrssttaannddiinnggooffEElilimmininaattiioonn HHaallff--LLiiffee
HHDuuuPmmoanannt DDwaaatstaa:i:nterested in any measurements of PFOA in general population
sDaumpPloenst.wGaesairnyteprersotveiddeind aannyomveeravsiuerwemofenwthsaotfwPeFOcuArrienntgleyneurnadleprostpaunldataionnd
ssssahahmomopwwplleeeeddss.tthhGeeerraeerccyeennpttroddavatitdaaeffdrrooammn
deceased overview
deceased
individuals of what we
individuals
matched liver and serum currently understand and
matched liver and serum
samples.
Geary then gave an overview of on-going or planned research, including the
GHHPaoeocpaipkfrkiyicinntNhsseWccnoollgglleaaarbvbioeoartraaartnitiicooosnnva,,emttrphvhleeieeGGwsrraooonfuudoppntAAh-geS.oSaiitrdrneuegplp.t.oscrclalpiignnleiaicdcnaanl2l.e0-ttdr.ri5iara9lelssppeaeeamddrpicialahtet,rrsiiinccfcrsslaoaummmdpipbnlllgeeosost,dh.ttehhee
Pbwbaaiannctkihksfsi.rc.eNsDDpW ueuPcPtogontenotrtiPaeetFxxrpipOcrrAeesssadssmeeetddpelraaemnnsinaiinanntttdeierroteenhsssett.
in the adults
in the
outcome of aged 20-59
outcome of
these sampling programs samples from blood
these sampling programs
with respect to PFOA determinations.
3M emphasized, once again, that the presence of telomer in samples has not been a3Mfoceumspohfaosuizreidn,voesntciegaatgiaoinns, that the presence of telomer in samples has not been
a focus of our investigations.
EliminationHaltLife: EDDGeuluiaPPmrooyinrnktsatthaaioosskwnkeeeHdddafftloofh-rreL33irMM fee'c:'sesnuutnndddaeetrrasstftaarnnoddmiinongugroofrfettthhiereeeeellimimomniiinnatatotiirooinnnghhaapllrff-loligiffreeaffmoo,rrTPPhFFiOOsAAd.ata Gsuegagreystsshoawmeudchthelornegceernhtadlafltaifferoomf eoliumrirneattiireoen mfroonmitsoerrinugmptrhoagtrhaams.beTehnis data
suggests a much longer half-life of elimination from serum that has been
33MM CCoonnf2ifiddeennttiiaall 2
11772211..00000022
3SMMAAc000446699991122
observed in other species, including cynomolgus monkeys. While its consistent owibtshertvheedrienpoorthteedr espliemciiensa,tiinocnluhadlinLigfceyinno3mMo'lguprsemvioonuksepyusb.liWcahtiiloenist,iDs ucPoonnsitstdeindt wnnaoopitttrhssoetebheelmeemtrmteoowpaiaoctcrchcteeetpdphtteettldhihamaattati.ntthhaiitDssiuowwPnaaohssnatrrlefe-aoallfli,,ffeeaarninenddd3iinM nnotti'rismamptaairtteoeenvddailotthehuaascttoptnthuchebeeylyrincbbiaeentlligiioeentvvshee,eddDcttohuhnePetrroeeennwwttiadaossind athpatrotbhleem halwF-litihfetdhaetdaamtaa.yDbuePionnetrroofrfeortehdernothraantiothnealdeifcfoenrecnecrensinbgetthweeeconntention `teihenxxadppiteectrrahiitmemeehednnattlthafaa-llltissftppeheeidccsiaieeftsaasacm atnonarddyhmmabadeann.ib.neeeW Wnrhrhiotilarleekoetttnhhheeieyynrttssohuucassonppneestchcitdteeeedrddaifrtrfeiee-o-reneex.xnppcooesssturbreee,,twGGeeeaearnryy
indicated that this factor had been taken into consideration.
lNNeosotstcaaobbneecnneeer.:"nTTehdheewiiimmtpphrrPeesFsssOiioAonndwwauasstecoctoohnnevvseehyyoeerddtttehhraastteDDruuuPlm~oonentltiaamssisnsuautmmieeodndthtahhleefEEliFPfAAe wwaass lsooeubsgbssgecersosvnteecediedirnrnanrreseveldssieegweahaitrrtldcchyhhPhaaiFnrgOithimmAearaldslms.u.eedTTitohhaeenthddheaaatsltaahfloGGirefeteaearfrroyysrepprrPrueeFsmsOeennAettleeiamdds,,ionwwpahphdioioccsnhhehdccauutrlrofrr-ePleinnfOtetllSyy `suagpgpeesaterdteoda srlaiigshestloymteugchoenrcmerend.ian haff-li[e [or PFOA as opposed to PFOS
appeared to raise some concern.
OKKitinhneeettriicctssh::an the datathat3M was already aware of, DuPont had litte to offer in Oretghaerrdthtoanphtahremdacaotakithneatti3cMs owrahsuamlraenadsyamapwlianrge.ofT, hDeuyPwoinllt hpardocleitetldewtiotohffer in `reLeemagmbppallrtodooyydteeoeeevpmemhlooaonrnpimittsoaoercrriionunkggminaaaennntadidclysaasrroieerscchtuueurrcrmrheennanitntqllyuyseaccsmoo.mpmlmimunngui.nciTcaahtteiinynggwwwiililttphhrttohhceeeeEEdnnvvwiirritoohnnmmeennttaall
Lab to develop serum analysis techniques.
`GKGiaanrreytyiJJceesp,p"ssooanndhhoaacdduaamllisesttnhooetff qqpuureeossvttiiiodonnessd rrteeollauattseed(datttotoahhcihissed"")A.AppHppirrsooqaauccehhstffooirronDDseesiscncicibbliuindneggdP:PFE1OO)AA sKoixnedtiifcfse,r"eancdeso;cu2)maebnstohrpetpiroonvciodeeffdictoieuntss(faotrtadcehremda).l aHnisdqouraelsteixopnossiunrcelu(dtehdey: 1) esesxtidmiaftfeertehnecedse;r2m)aalbasbosroprtpiotniocnoceofefficfiiecnitesntfotro dbee1rmxal1an0demo-rah5l rexipno2s0ur%e a(tqhueeyous seosltiumtiaonte);th3)e tdiesrsmueaplaarbtistoiropnticooneffcioceifefnitcsi;en4t)tsokibne eIxxpo1s0u-5recdmat/ah;r5i)no2r0al% aqueous dsoislutrtiiobnut);io3n) t(i3ssMuoefpfearretidtiaoncocpoyefoffictiehnetrsa;d4i)oslkabinelesxtpuodsyu);re6)daotraa;l5a)bosorarlption rate cdoinsstrtiabnutt;ioannd(,3M7)oifnffeorerdmaaticoonpoynofpatrhteitriaodniionlga,bedilfsftuusdiyon),; 6p)rootreailnabbisnodrpintigon(3rMate ocfofnesrteadntf;aattnyd-,ac7i)d icnafrorrimera-tpiroonteoinn bpianrdtiitinognsitnugdi,eds)if.fusion, protein binding (3M
offered fatty-acid carrier-protein binding studies).
DuPont asked for our participation in assisting them with a better understanding oDfuPPFoOntAaksikneetdicfso.r oTuhrepyadritidcicpoanttioenndinthaastsitshteinregctohuelmd wbeitshpeacbieesttedrifufnerdeenrcsetsaninding boifnPdFiOngAokriontehtiecrs.chTarhaecytedriidstcicosnttehnatdmtihgahtttheexrpelacionutldhebleosnpgeecreielsimdiifnfaetrieonncheaslint life bininhduimnagnosr.other characteristics that might explain the longer elimination half-life
in humans.
Descriptive Toxicology, inparticular, Functional Reproduction
Descriptive Toxicology, in particular, Functional Reproduction
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that, if and when 3M conducts the study, DuPont is certainly welcome to review
33MM CCoonnf3fiiddeennttiiaall 3
11772211..00000033
3MMA0A000446699991133
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respective senior management should address.
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alternagve plans to be developed, i~necessary.
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that the twhraittttheen
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had still not been written up into a report format.
SSuurmammaawry_
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ttios thpeoisrsmibalneatgheamt tehnetyoanrethbeelienvgelreoqfureisskteadsstoocbiraitendg fwoirthwacrodnstiinmuileadruse of APFO.
orIrteencicsotoepmmlommosemseneibndrldaecatottihimooapnntosstuhwwneidiyttshha.rrreeeggbaaerriddngttoorettqeelulooemmseterersds..tToThbhereinEEgPPAAforhhwaassarnndoottsiyymeettilaaassrkkeedd
for
for
ddaattaa
on telomer compounds.
DuPontwishes to work with 3M in gaining a more complete understanding of DAPuFPOo.ntTwhiesheensvitorownmoernktwalithfa3teManindgeaffiencitnsg, kainmetoircescaonmdprleepteroudnudcteirsvteabnidoilnoggyofare kAePyFaOr.eaTshoef einntverireostn.mental fate and effects, kinetics and reproductive biology are
key areas of interest.
PPrreeppaarreedd bbyy JJoohhnn BBuutteennhhooffff oonn JJuullyy 1111,, 22000000 33MM CCoonnfsfiiddeennttiiaall
4
11772211..00000044
SMACO69914
3MA00469914
DDiissttariibbuuttiioonn
DDaallee BBaaccoonn
SSTuuoeemBBDeeiaaPccahhsquale
Tom DiPasquale
DPDaaaunnl HHLaiakekdeeessr JPJNeeeaffluff dlM MaLaaniMnedaddereeelrlcki
GNeeolrdga eMMialrelectki
GGCGeheeauaorcrryygkeOORlMelssiieeclnnlhet
Chuck Reich
DDaavvee SSaannddeerrss
MBMiilikkleWeeSSpaanpntntooerrroo
:
LBailrlrWy Zeopbpenler
Larry Zobel
33MM CCoonnfyifiddeennttiiaall
11772211..00000055
3MADOAG9915
3MA00469915