Document nkoye46w6Oxw2BZq64Rgro7v2

ABD00019810 STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY OFFICE OF ENVIRONMENTAL HEALTH HAZARD ASSESSMENT SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986 CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER OR REPRODUCTIVE TOXICITY JUNE 2, 2000 The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and republish at least once per year the list of chemicals known to the State to cause cancer or reproductive toxicity The identification number indicated in the following list is the Chemical Abstracts Service (CAS) Registry Number No CAS number is given when several substances are presented as a single listing The date refers to the initial appearance of the chemical on the list For easy reference, chemicals which are shown underlined are newly added Chemicals which are shown with a strikeout are chemicals recommended for removal from the list by the "state's qualified experts " CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER Chemical A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) Acetaldehyde Acetamide Acetochlor 2-Acetylaminofluorene Acifluorfen Acrylamide Acrylonitrile Actinomycin D Adriamycin (Doxorubicin hydrochloride) AF-2,[2-(2-furyl)-3-(5-mtro-2-furyl)]acrylamide Aflatoxins Alachlor Alcoholic beverages, when associated with alcohol abuse Aldnn AIM chterwie Delisted October 29.1999 2-Aminoanthraquinone p-Ammoazobenzene ortho-Ammoazotoluene 4-Aminobiphenyl (4-aminodiphenyl) 1-Amino-2,4-dibromoanthraqumone 3-Amino-9-ethylcarbazole hydrochloride 2-Aminofluorene 1-Amino-2-methylanthraquinone 2-Amino-5-(5-mtro-2-furyl)-1,3,4-thiadiazole 4-Amino-2-mtrophenol Amitrole Analgesic mixtures containing phenacetin Aniline Aniline hydrochloride ortho-Amsidme ortho-Amsidine hydrochloride Antimony oxide (Antimony trioxide) Aramite Arsenic (inorganic arsenic compounds) Asbestos Auramme Azacitidine CAS Number 26148685 75070 60355 34256821 53963 62476599 79061 107131 50760 23214928 3688537 -- 15972608 ... 309002 107051 117793 60093 97563 92671 81492 6109973 153786 82280 712685 119346 61825 ... 62533 142041 90040 134292 1309644 140578 ... 1332214 492808 320672 Date January 1, 1990 April 1, 1988 January 1, 1990 January 1, 1989 July 1, 1987 January 1, 1990 January 1, 1990 July 1, 1987 October 1, 1989 July 1, 1987 July 1, 1987 January 1, 1988 January 1, 1989 July 1, 1988 July 1, 1988 January 1,1990 October 1, 1989 January 1, 1990 July 1, 1987 February 27, 1987 August 26, 1997 July 1, 1989 January 29, 1999 October 1, 1989 July 1, 1987 January 29, 1999 July 1, 1987 February 27, 1987 January 1, 1990 May 15, 1998 July 1, 1987 July 1, 1987 October 1, 1990 July 1, 1987 February 27, 1987 February 27, 1987 July 1, 1987 January 1, 1992 ABD00019811 2- - Azaserme Azathioprine Azobenzene Benz[a]anthracene Benzene Benzidine [and its salts] Benzidine-based dyes Benzo[b]fluoranthene Benzo[|]fluoranthene Benzo[k]fluoranthene Benzofuran Benzo[a]pyrene Benzotrichlonde Benzyl chlonde Benzyl violet 4B Beryllium and beryllium compounds Betel quid with tobacco 2,2-Bis(bromomethyl)-1,3-propanediol Bis(2-chloroethyl)ether N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine) Bischloroethyl nitrosourea (BCNU) (Carmustine) Bis(chloromethyl)ether Bis(2-chloro-1-methylethyl)ether, technical grade Bitumens, extracts of steam-refined and air refined Bracken fern Bromodichloromethane Bromoform 1,3-Butadiene 1,4-Butanediol dimethanesulfonate (Busulfan) Butylated hydroxyamsole beta-Butyrolactone Cacodylic acid Cadmium and cadmium compounds Caffeic acid Captafol Captan Carbazole Carbon tetrachloride Carbon-black extracts Ceramic fibers (airborne particles of respirable size) Certain combined chemotherapy for lymphomas Chlorambucil Chloramphenicol Chlordane Chlordecone (Kepone) Chlordimeform Chlorendic acid Chlorinated paraffins (Average chain length, C12, approximately 60 percent chlorine by weight) p-Chloroaniline p-Chloroamhne hydrochloride Chtorodibromomethane Delisted October 29. 1999 Chloroethane (Ethyl chloride) 1-(2-Chloroethyl)-3-cyclohexyl-1-mtrosourea (CCNU) (Lomustine) 115026 446866 103333 56553 71432 92875 -- 205992 205823 207089 271896 50328 98077 100447 1694093 -- -- 3296900 111444 494031 154938 542881 -- -- -- 75274 75252 106990 55981 25013165 3068880 75605 -- 331395 2425061 133062 86748 56235 -- -- -- 305033 56757 57749 143500 6164983 115286 108171262 106478 20265967 454484 75003 13010474 July 1, 1987 February 27, 1987 January 1, 1990 July 1, 1987 February 27, 1987 February 27, 1987 October 1, 1992 July 1,1987 July 1, 1987 July 1, 1987 October 1, 1990 July 1, 1987 July 1, 1987 January 1, 1990 July 1, 1987 October 1, 1987 January 1, 1990 May 1, 1996 April 1, 1988 February 27, 1987 July 1, 1987 February 27, 1987 October 29, 1999 January 1, 1990 January 1, 1990 January 1, 1990 April 1, 1991 April 1, 1988 February 27, 1987 January 1, 1990 July 1, 1987 May 1, 1996 October 1, 1987 October 1, 1994 October 1, 1988 January 1, 1990 May 1,1996 October 1, 1987 January 1, 1990 July 1, 1990 February 27, 1987 February 27, 1987 October 1, 1989 July 1, 1988 January 1, 1988 January 1, 1989 July 1, 1989 July 1, 1989 October 1, 1994 May 15, 1998 January 1,1990 July 1, 1990 January 1, 1988 2 ABD00019812 i -3- 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1- nitrosourea (Methyl-CCNU) Chloroform Chloromethyl methyl ether (technical grade) 3-Chloro-2-methylpropene 1 -Chloro-4-mtrobenzene 4-Chloro-ortho-phenylenediamine p-Chloro-o-toluidine p-Chloro-o-toluidine, strong acid salts of 5-Chloro-o-toluidine and its strong acid salts Chloroorene Chlorothaloml Chlorotriamsene Chlorozotocin Chromium (hexavalent compounds) Chrysene C 1 Acid Red 114 C 1 Basic Red 9 monohydrochloride C 1 Direct Blue 15 Cl Direct Blue 218 C 1 Solvent Yellow 14 Ciclosporin (Cyclosporin A, Cyclosporine) Cidofovir Cinnamyl anthramlate Cisplatin Citrus Red No 2 Clofibrate Cobalt metal powder Cobalt [II] oxide Cohalt sulfate hentahvdrate Coke oven emissions Conjugated estrogens Creosotes para-Cresidme Cupferron Cycasin Cyclophosphamide (anhydrous) Cyclophosphamide (hydrated) Cytembena D&C Orange No 17 D&C Red No 8 D&C Red No 9 D&C Red No 19 Dacarbazine Daminozide Dantron (Chrysazin, 1,8-Dihydroxyanthraquinone) Daunomycin DDD (Dichlorodiphenyldichloroethane) DDE (Dichlorodiphenyldichloroethylene) DDT (Dichlorodiphenyltrichloroethane) DDVP (Dichlorvos) N,N'-Diacetylbenzidine 2,4-Diaminoamsole 2,4-Diaminoamsole sulfate 4,4'-Diaminodiphenyl ether (4,4'-Oxydiamline) 13909096 67663 107302 563473 100005 95830 95692 -- -- 126998 1897456 569573 54749905 -- 218019 6459945 569619 2429745 28407376 842079 59865133 79217600 113852372 87296 15663271 6358538 637070 7440484 1307966 10026241 -- -- -- 120718 135206 14901087 50180 6055192 21739913 3468631 2092560 5160021 81889 4342034 1596845 117102 20830813 72548 72559 50293 62737 613354 615054 39156417 101804 October 1, 1988 October 1, 1987 February 27, 1987 July 1, 1989 October 29, 1999 January 1, 1988 January 1, 1990 May 15, 1998 October 24, 1997 June 2. 2000 January 1, 1989 September 1, 1996 January 1, 1992 February 27, 1987 January 1, 1990 July 1, 1992 July 1, 1989 August 26, 1997 August 26, 1997 May 15, 1998 January 1, 1992 January 29, 1999 July 1, 1989 October 1, 1988 October 1, 1989 September 1, 1996 July 1, 1992 July 1, 1992 June 2. 2000 February 27, 1987 February 27, 1987 October 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 February 27, 1987 February 27, 1987 May 15, 1998 July 1, 1990 October 1, 1990 July 1, 1990 July 1, 1990 January 1, 1988 January 1, 1990 January 1, 1992 January 1, 1988 January 1, 1989 January 1, 1989 October 1,1987 January 1, 1989 October 1, 1989 October 1, 1990 January 1, 1988 January 1, 1988 3 ABD00019813 -4- 2,4-Diaminotoluene Diaminotoluene (mixed) Dibenz[a,h]acridine Dibenz[a,j]acridme Dibenz[a,h]anthracene 7H-Dibenzo(c,g]carbazole Dibenzo[a,e]pyrene Dibenzo[a,hjpyrene Dibenzo[a,i]pyrene Dibenzo[a,ljpyrene 1,2-Dibromo-3-chloropropane (DBCP) 2,3-Dibromo-1 -propanol Dichloroacetic acid p-Dichlorobenzene 3,3'-Dichlorobenzidine 3,3'-Dichlorobenzidine dihydrochloride 1,4-Dichloro-2-butene 3,3'-Dichloro-4,4'-diaminodiphenyl ether 1,1-Dichloroethane Dichloromethane (Methylene chloride) 1,2-Dichloropropane 1,3-Dichloropropene Dieldrm Dienestrol Diepoxybutane Diesel engine exhaust Di(2-ethylhexyl)phthalate 1,2-Diethylhydrazine Diethyl sulfate Diethylstilbestrol (DES) Diglycidyl resorcinol ether (DGRE) Dihydrosafrole Dnsopropyl sulfate 3,3'-Dimethoxybenzidine (ortho-Diamsidine) 3,3'-Dimethoxybenzidme dihydrochloride (ortho-Diamsidine dihydrochloride) Dimethyl sulfate 4-Dimethylaminoazobenzene trans-2-[(Dimethylamino)methylimino]-5-[2-(5-mtro-2- furyl)vmyl]-1,3,4- oxadiazole 7,12-Dimethylbenz(a)anthracene 3,3'-Dimethylbenzidine (ortho-Tolidme) 3,3-Dimethylbenzidine dihydrochloride Dimethylcarbamoyl chloride 1,1-Dimethylhydrazme (UDMH) 1,2-Dimethylhydrazine Dimethylvinylchloride 3,7-Dimtrofiuoranthene 3,9-Dimtrofluoranthene 1,6-Dimtropyrene 1,8-Dmitropyrene Dimtrotoluene mixture, 2,4-/2,62,4-Dmitrotoluene 2,6-Dimtrotoluene Di-n-propyl isocinchomeronate (MGK Repellent 326) 1,4-Dioxane Diphenylhydantoin (Phenytoin) 95807 -- 226368 224420 53703 194592 192654 189640 189559 191300 96128 96139 79436 106467 91941 612839 764410 28434868 75343 75092 78875 542756 60571 84173 1464535 -- 117817 1615801 64675 56531 101906 94586 2973106 119904 20325400 77781 60117 55738540 57976 119937 612828 79447 57147 540738 513371 105735715 22506532 42397648 42397659 -- 121142 606202 136458 123911 57410 January 1, 1988 January 1,1990 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1988 July 1, 1987 October 1,1994 May 1,1996 January 1, 1989 October 1, 1987 May 15, 1998 January 1, 1990 January 1, 1988 January 1, 1990 April 1, 1988 January 1, 1990 January 1, 1989 July 1, 1988 January 1, 1990 January 1, 1988 October 1, 1990 January 1, 1988 January 1, 1988 January 1, 1988 February 27, 1987 July 1, 1989 January 1, 1988 April 1, 1993 January 1, 1988 October 1, 1990 January 1, 1988 January 1, 1988 January 1, 1988 January 1, 1990 January 1, 1988 April 1, 1992 January 1, 1988 October 1, 1989 January 1, 1988 July 1, 1989 August 26, 1997 August 26, 1997 October 1,1990 October 1, 1990 May 1, 1996 July 1, 1988 July 1, 1995 May 1,1996 January 1, 1988 January 1, 1988 ABD00019814 -5- Diphenylhydantoin (Phenytoin), sodium salt Direct Black 38 (technical grade) Direct Blue 6 (technical grade) Direct Brown 95 (technical grade) Disperse Blue 1 Epichlorohydrin Eriomte Estradiol 17B Estragole Estrone Estropipate Ethinylestradiol Ethyl acrylate Ethyl methanesulfonate Ethyl-4,4'-dichlorobenzilate Ethylene dibromide Ethylene dichlonde (1,2-Dichloroethane) Ethylene oxide Ethylene thiourea Ethyleneimme Fenoxvcarb Folpet Formaldehyde (gas) 2-(2-Formylhydrazino)-4-(5-mtro-2-furyl)thiazole Furan Furazolidone Furmecyclox Fusarin C Ganciclovir sodium Gasoline engine exhaust (condensates/extracts) Glasswool fibers (airborne particles of respirable size) Glu-P-1 (2-Amino-6-methyldipyrido[1,2- a 3',2'-d]imidazole) Glu-P-2 (2-Aminodipyndo[1,2-a 3',2'-d]imidazole) Glycidaldehyde Glycidol Griseofulvin Gyromitnn (Acetaldehyde methylformylhydrazone) HC Blue 1 Heptachlor Heptachlor epoxide Hexachlorobenzene Hexachlorocyclohexane (technical grade) Hexachlorodibenzodioxm Hexachloroethane Hexamethylphosphoramide Hydrazine Hydrazine sulfate Hydrazobenzene (1,2-Diphenylhydrazine) Indeno [1,2,3-cd]pyrene IQ (2-Amino-3-methylimidazo[4,5-f]quinoline) Iprodione 630933 1937377 2602462 16071866 2475458 106898 12510428 50282 140670 53167 7280377 57636 140885 62500 510156 106934 107062 75218 96457 151564 72490018 133073 50000 3570750 110009 67458 60568050 79748815 82410320 67730114 67730103 765344 556525 126078 16568028 2784943 76448 1024573 118741 34465468 67721 680319 302012 10034932 122667 193395 76180966 36734197 January 1, 1988 January 1, 1988 January 1, 1988 October 1, 1988 October 1, 1990 October 1, 1987 October 1, 1988 January 1, 1988 October 29, 1999 January 1, 1988 August 26, 1997 January 1, 1988 July 1, 1989 January 1, 1988 January 1, 1990 July 1, 1987 October 1, 1987 July 1, 1987 January 1, 1988 January 1, 1988 June 2. 2000 January 1, 1989 January 1, 1988 January 1, 1988 October 1, 1993 January 1, 1990 January 1, 1990 July 1, 1995 August 26, 1997 October 1, 1990 July 1, 1990 January 1, 1990 January 1, 1990 January 1, 1988 July 1, 1990 January 1, 1990 January 1, 1988 July 1, 1989 July 1, 1988 July 1, 1988 October 1, 1987 October 1, 1987 April 1, 1988 July 1, 1990 January 1, 1988 January 1, 1988 January 1,1988 January 1, 1988 January 1, 1988 April 1, 1990 May 1, 1996 5 ABD00019815 6- - Iron dextran complex Isobutyl mtnte Isoprene Isosafrole Lactofen Lasiocarpine Lead acetate Lead and lead compounds Lead phosphate Lead subacetate Lindane and other hexachlorocyclohexane isomers Mancozeb Maneb Me-A-alpha-C (2-Amino-3-methyl-9H-pyndo[2,3-b]indole) Medroxyprogesterone acetate MelQ(2-Amino-3,4-dimethylimidazo[4,5-f]quinoline) MelQx(2-Amino-3,8-dimethylimidazo[4t5-f]quinoxaline) Melphalan Merphalan Mestranol Metham sodium 8-Methoxypsoralen with ultraviolet A therapy 5-Methoxypsoralen with ultraviolet A therapy 2-Methylaziridine (Propyleneimme) Methylazoxymethanol Methylazoxymethano! acetate Methyl carbamate 3-Methylcholanthrene 5-Methylchrysene 4,4'-Methylene bis(2-chloroamhne) 4,4-Methylene bis(N,N-dimethyl)benzenamine 4,4-Methylene bis(2-methylamline) 4,4-Methylenedianiline 4,4'-Methylenedianiline dihydrochloride Methylhydrazine and its salts Methyl iodide Methylmercury compounds Methyl methanesulfonate 2-Methyl-l-mtroanthraquinone (of uncertain purity) N-Methyl-N'-nitro-N-nitrosoguamdine N-Methylolacrylamide Methylthiouracil Metiram Metronidazole Michler's ketone Mirex Mitomycin C Monocrotaline 5-(Morpholinomethyl)-3-((5-nitro-furfurylidene)-ammo]-2-oxazolidinone Mustard Gas Nafenopm Nalidixic acid 1-Naphthylamme 9004664 542563 78795 120581 77501634 303344 301042 -- 7446277 1335326 -- 8018017 12427382 68006837 71589 77094112 77500040 148823 531760 72333 137428 298817 484208 75558 590965 592621 598550 56495 3697243 101144 101611 838880 101779 13552448 -- 74884 -- 66273 129157 70257 924425 56042 9006422 443481 90948 2385855 50077 315220 139913 505602 3771195 389082 134327 January 1,1988 May 1,1996 May 1,1996 October 1,1989 January 1,1989 April 1, 1988 January 1,1988 October 1,1992 April 1, 1988 October 1,1989 October 1,1989 January 1,1990 January 1,1990 January 1,1990 January 1,1990 October 1,1994 October 1, 1994 February 27, 1987 April 1, 1988 April 1, 1988 November 6, 1998 February 27, 1987 October 1,1988 January 1,1988 April 1, 1988 April 1, 1988 May 15, 1998 January 1, 1990 April 1,1988 July 1, 1987 October 1, 1989 April 1, 1988 January 1,1988 January 1,1988 July 1, 1992 April 1, 1988 May 1, 1996 April 1, 1988 April 1, 1988 April 1, 1988 July 1, 1990 October 1, 1989 January 1, 1990 January 1,1988 January 1,1988 January 1,1988 April 1, 1988 April 1, 1988 April 1, 1988 February 27,1987 April 1, 1988 May 15, 1998 October 1, 1989 6 ABD00019816 -7- 2-Naphthylamine Nickel and certain nickel compounds Nickel carbonyl Nickel refinery dust from the pyrometallurgical process Nickel subsulfide Niridazole Nitnlotriacetic acid Nitnlotnacetic acid, trisodium salt monohydrate 5-Nitroacenaphthene 5-Nitro-o-amsidine o-Nitroamsole Nitrobenzene 4-Nitrobiphenyl 6-Nitrochrysene Nitrofen (technical grade) 2-Nitrofluorene Nitrofurazone 1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide Nitrogen mustard (Mechlorethamme) Nitrogen mustard hydrochlonde (Mechlorethamme hydrochloride) Nitrogen mustard N-oxide Nitrogen mustard N-oxide hydrochlonde Nitromethane 2-Nitropropane 1-Nitropyrene 4-Nitropyrene N-Nitrosodi-n-butylamine N-Nitrosodiethanolamine N-Nitrosodiethylamine N-Nitrosodimethylamine p-Nitrosodiphenylamine N-Nitrosodiphenylamine N-Nitrosodi-n-propylamine N-Nitroso-N-ethylurea 3-(N-Nitrosomethylamino)propionitnle 4-(N-Nitrosomethylamino)-1-(3-pyridyl)1-butanone N-Nitrosomethylethylamine N-Nitroso-N-methylurea N-Nitroso-N-methylurethane N-Nitrosomethylvmylamine N-Nitrosomorpholine N-Nitrosonormcotine N-Nitrosopiperidme N-Nitrosopyrrolidine N-Nitrososarcosine oNitrotoluene Norethisterone (Norethindrone) Ochratoxin A Oil Orange SS Oral contraceptives, combined Oral contraceptives, sequential Oxadiazon Oxazepam Oxymetholone 91598 -- 13463393 -- 12035722 61574 139139 18662538 602879 99592 91236 98953 92933 7496028 1836755 607578 59870 555840 531828 51752 55867 126852 302705 75525 79469 5522430 57835924 924163 1116547 55185 62759 156105 86306 621647 759739 60153493 64091914 10595956 684935 615532 4549400 59892 16543558 100754 930552 13256229 88722 68224 303479 2646175 -- -- 19666309 604751 434071 February 27,1987 October 1,1989 October 1,1987 October 1, 1987 October 1,1987 Apnl 1, 1988 January 1,1988 Apnl 1,1989 Apnl 1, 1988 October 1,1989 October 1,1992 August 26, 1997 April 1, 1988 October 1, 1990 January 1,1988 October 1,1990 January 1,1990 Apnl 1, 1988 Apnl 1, 1988 January 1, 1988 Apnl 1, 1988 Apnl 1, 1988 Apnl 1, 1988 May 1,1997 January 1,1988 October 1,1990 October 1,1990 October 1, 1987 January 1,1988 October 1,1987 October 1, 1987 January 1,1988 Apnl 1, 1988 January 1, 1988 October 1, 1987 April 1, 1990 Apnl 1, 1990 October 1,1989 October 1,1987 Apnl 1, 1988 January 1,1988 January 1,1988 January 1,1988 January 1,1988 October 1,1987 January 1,1988 May 15, 1998 October 1,1989 July 1,1990 Apnl 1, 1988 October 1,1989 October 1,1989 July 1,1991 October 1,1994 January 1,1988 ABD00019817 8- - Oxythioqumox 2439012 Palygorskite fibers (> 5pm in length) Panfuran S Pentachlorophenol Phenacetin Phenazopyridme Phenazopyndme hydrochlonde Phenesterin Phenobarbital Phenolphthalem Phenoxybenzamine Phenoxybenzamine hydrochloride o-Phenylenediamme and its salts Phenyl glycidyl ether Phenylhydrazine and its salts o-Phenylphenate, sodium PhiP(2-Amino-1-methyl-6-phenylimidazol[4,5-b]pyridine) Polybrominated biphenyls Polychlorinated biphenyls Polychlorinated biphenyls (containing 60 or more percent chlorine by molecular weight) Polychlorinated dibenzo-p-dioxms Polychlorinated dibenzofurans Polygeenan Ponceau MX Ponceau 3R Potassium bromate Primidone Procarbazine Procarbazine hydrochlonde Procymidone Progesterone 1,3-Propane sultone Propargite Pronamide beta-Propiolactone Propylene oxide Propylthiouracil 12174117 794934 87865 62442 94780 136403 3546109 50066 77098 59961 63923 95545 122601 -- 132274 105650235 -- -- -- -- -- 53973981 3761533 3564098 7758012 125337 671169 366701 32809168 57830 1120714 2312358 23950585 57578 75569 51525 Quinoline and its strong acid salts -- Radionuclides Reserpine Residual (heavy) fuel oils ... 50555 -- Sacchann Saccharin, sodium Safrole Salicylazosulfapyndine Selenium sulfide Shale-oils Silica, crystalline (airborne particles of respirable size) Soots, tars, and mineral oils (untreated and mildly treated oils and used engine oils) Spironolactone 81072 128449 94597 599791 7446346 68308349 ... ... 52017 August 20, 1999 December 28, 1999 January 1, 1988 January 1,1990 October 1,1989 January 1,1988 January 1,1988 July 1,1989 January 1,1990 May 15, 1998 April 1, 1988 April 1, 1988 May 15, 1998 October 1, 1990 July 1, 1992 January 1,1990 October 1,1994 January 1,1988 October 1, 1989 January 1,1988 October 1, 1992 October 1, 1992 January 1, 1988 April 1, 1988 April 1, 1988 January 1, 1990 August 20,1999 January 1, 1988 January 1,1988 October 1,1994 January 1, 1988 January 1,1988 October 1, 1994 May 1, 1996 January 1, 1988 October 1,1988 January 1, 1988 October 24, 1997 July 1, 1989 October 1, 1989 October 1,1990 October 1, 1989 January 1, 1988 January 1,1988 May 15,1998 October 1,1989 April 1,1990 October 1,1988 February 27, 1987 May 1,1997 8 ABD00019818 -9- Stanozolol Stengmatocystin Streptozotocin (streptozocin) Styrene oxide Sulfallate Talc containing asbestiform fibers Tamoxifen and its salts Terrazole Testosterone and its esters 2,3,7,8-Tetrachlorodibenzo-para-dioxm (TCDD) 1,1,2,2-Tetrachloroethane Tetrachloroethylene (Perchloroethylene) p-a,a,a-Tetrachlorotoluene Tetrafluoroethylene Tetramtromethane Thioacetamide 4,4'-Thiodiamline Thiodicarb Thiourea Thorium dioxide Tobacco, oral use of smokeless products Tobacco smoke Toluene dnsocyanate ortho-Toluidme ortho-Toluidme hydrochlonde para-Toluidine Delisted October 29.1999 Toxaphene (Polychlorinated camphenes) Treosulfan Tnchlormethine (Trimustine hydrochloride) Tnchloroethylene 2,4,6-Trichlorophenol 1,2,3-Trichloropropane Trimethyl phosphate 2,4,5-Trimethylamline and its strong acid salts Tnphenyltin hydroxide Tns(aziridinyl)-para-benzoqumone (Triaziquone) Tris(1-azmdinyi)phosphme sulfide (Thiotepa) Tns(2-chloroethyl) phosphate Tns(2,3-dibromopropyl)phosphate Trp-P-1 (Tryptophan-P-1) Trp-P-2 (Tryptophan-P-2) Trypan blue (commercial grade) Unleaded gasoline (wholly vaporized) Uracil mustard Urethane (Ethyl carbamate) Vinclozolin Vinyl bromide Vinyl chloride 4-Vinylcyclohexene 4-Vinyl-1-cyclohexene diepoxide (Vinyl cyclohexenedioxide) Vinyl fluoride Vinyl trichloride (1,1,2-Trichloroethane) 10418038 10048132 18883664 96093 95067 -- 10540291 2593159 58220 1746016 79345 127184 5216251 116143 509148 62555 139651 59669260 62566 1314201 -- -- 26471625 95534 636215 106490 8001352 299752 817094 79016 88062 96184 512561 -- 76879 68768 52244 115968 126727 62450060 62450071 72571 ____ 66751 51796 50471448 593602 75014 100403 106876 75025 79005 May 1, 1997 April 1, 1988 January 1, 1988 October 1,1988 January 1, 1988 April 1, 1990 September 1, 1996 October 1, 1994 April 1, 1988 January 1, 1988 July 1, 1990 April 1, 1988 January 1,1990 May 1,1997 July 1, 1990 January 1, 1988 April 1, 1988 August 20, 1999 January 1, 1988 February 27, 1987 April 1, 1988 April 1, 1988 October 1, 1989 January 1, 1988 January 1, 1988 January 1, 1990 January 1, 1988 February 27, 1987 January 1, 1992 April 1, 1988 January 1, 1988 October 1,1992 May 1, 1996 October 24, 1997 July 1, 1992 October 1, 1989 January 1, 1988 April 1, 1992 January 1, 1988 April 1, 1988 April 1, 1988 October 1, 1989 April 1, 1988 April 1, 1988 January 1, 1988 August 20, 1999 October 1,1988 February 27, 1987 May 1, 1996 July 1, 1990 May 1, 1997 October 1, 1990 9 ABD00019819 -10- 2,6- Xylidine (2,6-Dimethylamline) 3neb Delisted October 29.1999 87627 T40m-4B00B0w-7-r7r CHEMICALS KNOWN TO THE STATE TO CAUSE REPRODUCTIVE TOXICITY Developmental toxicity Acetazolamide Acetohydroxamic acid Actinomycin D All-trans retinoic acid Alprazolam Altretamine Amikacin sulfate Ammoglutethimide Aminoglycosides Aminoptenn Amiodarone hydrochloride Amitraz Amoxapine Angiotensin converting enzyme (ACE) inhibitors Amsindione Arsenic (inorganic oxides) Aspmn (NOTE It is especially important not to use aspmn during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications dunng delivery) Atenolol Auranofin Azathiopnne 59665 546883 50760 302794 28981977 645056 39831555 125848 -- 54626 19774824 33089611 14028445 -- 117373 -- 50782 29122687 34031328 446866 Barbiturates Beclomethasone dipropionate Benomyl Benzene Benzphetamine hydrochlonde Benzodiazepines Bischloroethyl nitrosourea (BCNU) (Carmustine) Bromacil lithium salt Bromoxyml Bromoxynil octanoate Butabarbital sodium 1,4-Butanediol dimethanesulfonate (Busulfan) -- 5534098 17804352 71432 5411223 -- 154938 53404196 1689845 1689992 143817 55981 Cadmium Carbamazepme Carbon disulfide Carbon monoxide Carboplatin Chenodiol Chinomethionat (Oxythioquinox) Chlorambucil Chlorcyclizine hydrochlonde Chlordecone (Kepone) Chlordiazepoxide 298464 75150 630080 41575944 474259 2439012 305033 1620219 143500 58253 January 1,1991 January 1990 August 20,1999 Apnl 1,1990 October 1,1992 January 1,1989 July 1,1990 August 20,1999 July 1,1990 July 1,1990 October 1,1992 July 1,1987 August 26, 1997 March 30, 1999 May 15, 1998 October 1,1992 October 1,1992 May 1,1997 July 1, 1990 August 26, 1997 January 29, 1999 September 1,1996 October 1,1992 May 15,1998 July 1, 1991 December 26,1997 April 1,1990 October 1,1992 July 1,1990 May 18, 1999 October 1,1990 May 18,1999 October 1,1992 January 1,1989 May 1,1997 January 29,1999 July 1,1989 July 1,1989 July 1,1990 Apnl 1, 1990 November 6,1998 January 1,1989 July 1,1987 January 1,1989 January 1,1992 10 ABDOOO19820 -11- Chlordiazepoxide hydrochlonde 1-(2-Chloroethyl)-3-cyclohexyl-1-mtrosourea (CCNU) (Lomustme) Chlorsulfuron Cidofovir Cladribme Clarithromycin Clobetasol propionate Clomiphene citrate Clorazepate dipotassium Cocaine Codeine phosphate Colchicine Conjugated estrogens Cyanazine Cycloate Cycloheximide Cyclophosphamide (anhydrous) Cyclophosphamide (hydrated) Cyhexatin Cytarabine Dacarbazme Danazol Daunorubicin hydrochloride 2,4-D butyric acid o,p'-DDT p,p'-DDT 2,4-DP (dichloroprop) Demeclocyclme hydrochloride (internal use) Diazepam Dichlorophene Diclofop methyl Dicumarol Diethylstilbestrol (DES) Diflumsal Dihydroergotamme mesylate Dmocap Dmoseb Diphenylhydantoin (Phenytoin) Disodium cyanodithiomidocarbonate Doxorubicin hydrochloride Doxycychne (internal use) Doxycycline calcium (internal use) Doxycychne hyclate (internal use) Doxycycline monohydrate (internal use) Endnn Ergotamine tartrate Estropipate Ethionamide Ethyl alcohol in alcoholic beverages Ethyl dipropylthiocarbamate Ethylene dibromide Ethylene glycol monoethyl ether Ethylene glycol monomethyl ether Ethylene glycol monoethyl ether acetate 438415 13010474 64902723 113852372 4291638 81103119 25122467 50419 57109907 50362 52288 64868 -- 21725462 1134232 66819 50180 6055192 13121705 147944 4342034 17230885 23541506 94826 789026 50293 120365 64733 439145 97234 51338273 66762 56531 22494424 6190392 39300453 88857 57410 138932 23214928 564250 94088854 24390145 17086281 72208 379793 7280377 536334 -- 759944 106934 110805 109864 111159 January 1, 1992 July 1, 1990 May 14, 1999 January 29, 1999 September 1,1996 May 1, 1997 May 15, 1998 April 1, 1990 October 1, 1992 July 1, 1989 May 15, 1998 October 1, 1992 April 1, 1990 April 1, 1990 March 19, 1999 January 1, 1989 January 1, 1989 January 1, 1989 January 1, 1989 January 1, 1989 January 29, 1999 April 1, 1990 July 1, 1990 June 18, 1999 May 15, 1998 May 15, 1998 April 27, 1999 January 1, 1992 January 1, 1992 April 27, 1999 March 5, 1999 October 1, 1992 July 1, 1987 January 29, 1999 May 1, 1997 April 1, 1990 January 1, 1989 July 1, 1987 March 30, 1999 January 29, 1999 July 1, 1990 January 1, 1992 October 1, 1991 October 1, 1991 May 15, 1998 April 1, 1990 August 26, 1997 August 26, 1997 October 1,1987 April 27, 1999 May 15, 1998 January 1, 1989 January 1, 1989 January 1, 1993 11 Ethylene glycol monomethyi ether acetate Ethylene thiourea Etodolac Etoposide Etretinate Fenoxaprop ethyl Fluazifop butyl Flumsolide Fluorouracil Fluoxymesterone Flurazepam hydrochloride Flurbiprofen Flutamide Fluticasone propionate Fluvalinate Ganciclovir sodium Goserelm acetate Halazepam Halobetasol propionate Halopendol Halothane Heptachlor Hexachlorobenzene Histrelin acetate Hydramethylnon Hydroxyurea Idarubicin hydrochlonde Ifosfamide Iodine-131 Isotretinoin Lead Leuprolide acetate Levodopa Linuron Lithium carbonate Lithium citrate Lorazepam Lovastatm Mebendazole Medroxyprogesterone acetate Megestrol acetate Melphalan Menotropins Meprobamate Mercaptopunne Mercury and mercury compounds Methacyclme hydrochlonde Metham sodium Methazole Methimazole ABDOOO19821 -12- 110496 96457 41340254 33419420 54350480 66441234 69806504 3385033 51218 76437 1172185 5104494 13311847 80474142 69409945 82410320 65807025 23092173 66852548 52868 151677 76448 118741 _ 67485294 127071 57852570 3778732 10043660 4759482 -- 74381536 59927 330552 554132 919164 846491 75330755 31431397 71589 595335 148823 9002680 57534 6112761 -- 3963959 137428 20354261 60560 January 1,1993 January 1, 1993 August 20, 1999 July 1, 1990 July 1, 1987 March 26, 1999 November 6,1998 May 15,1998 January 1,1989 April 1, 1990 October 1, 1992 August 20,1999 July 1, 1990 May 15, 1998 November 6,1998 August 26,1997 August 26, 1997 July 1, 1990 August 20,1999 January 29, 1999 September 1,1996 August 20, 1999 January 1, 1989 May 15, 1998 March 5, 1999 May 1,1997 August 20, 1999 July 1,1990 January 1,1989 July 1,1987 February 27,1987 August 26, 1997 January 29,1999 March 19, 1999 January 1,1991 January 1, 1991 July 1, 1990 October 1, 1992 August 20, 1999 April 1, 1990 January 1,1991 July 1,1990 April 1, 1990 January 1,1992 July 1,1990 July 1,1990 January 1,1991 May 15, 1998 December 1,1999 July 1, 1990 12 ABDOOO19822 -13- Methotrexate Methotrexate sodium Methyl bromide as a structural fumigant Methyl chlonde Methyl mercury Methyltestosterone Metiram Midazolam hydrochlonde Minocycline hydrochlonde (internal use) Misoprostol Mitoxantrone hydrochlonde Myclobutaml Nabam Nafarelin acetate Neomycin sulfate (internal use) Netilmicin sulfate Nickel carbonyl Nicotine Nifedipine Nitrapynn Nitrogen mustard (Mechlorethamme) Nitrogen mustard hydrochlonde (Mechlorethamme hydrochlonde) Norethisterone (Norethindrone) Norethisterone acetate (Norethindrone acetate) Norethisterone (Norethindrone)/Ethinyl estradiol Norethisterone (Norethindrone)/Mestranol Norgestrel Oxadiazon Oxazepam Oxymetholone Oxytetracycline (internal use) Oxytetracycline hydrochlonde (internal use) Paclitaxel Paramethadione Penicillamine Pentobarbital sodium Pentostatin Phenacemide Phenprocoumon Pimozide Pipobroman Plicamycin Polybrominated biphenyls Polychlonnated biphenyls Potassium dimethyldithiocarbamate Pravastatin sodium Prednisolone sodium phosphate Procarbazine hydrochlonde Propargite Propylthiouracil Pynmethamine Quazepam 59052 15475566 74839 74873 -- 58184 9006422 59467968 13614987 59122462 70476823 88671890 January 1,1989 April 1,1990 January 1,1993 March 10,2000 July 1,1987 April 1,1990 March 30, 1999 July 1,1990 January 1,1992 Apnl 1,1990 July 1,1990 Apnl 16,1999 142596 86220420 1405103 56391572 13463393 54115 21829254 1929824 51752 55867 68224 51989 68224/57636 68224/72333 6533002 March 30, 1999 Apnl 1, 1990 October 1,1992 July 1,1990 September 1,1996 April 1, 1990 January 29,1999 March 30,1999 January 1,1989 July 1,1990 Apnl 1, 1990 October 1, 1991 Apnl 1, 1990 Apnl 1,1990 Apnl 1,1990 19666309 604751 434071 79572 2058460 May 15,1998 October 1,1992 May 1,1997 January 1,1991 October 1,1991 33069624 115673 52675 57330 53910251 63989 435972 2062784 54911 18378897 -- -- 128030 81131706 125020 366701 2312358 51525 58140 August 26, 1997 July 1,1990 January 1,1991 July 1,1990 September 1, 1996 July 1,1990 October 1,1992 August 20, 1999 July 1, 1990 Apnl 1, 1990 October 1,1994 January 1,1991 March 30 1999 March 3, 2000 August 20, 1999 July 1,1990 June 15,1999 July 1,1990 January 29,1999 36735225 August 26, 1997 13 Resmethrin ABDOOO19823 -14- 10453868 November 6, 1998 14 ABDOOO19824 -15- Retinol/retinyl esters, when in daiiy dosages in excess of 10,000 IU, or 3,000 retinol equivalents (NOTE Retinol/retinyl esters are required and essential for maintenance of normal reproductive function The recommended daily level during pregnancy is 8,000 IU ) Ribavirin 36791045 Secobarbital sodium Sermorelin acetate Sodium dimethyldithiocarbamate Streptomycin sulfate Streptozocin (streptozotocin) Sulindac 309433 -- 128041 3810740 18883664 38194502 Tamoxifen citrate Temazepam Temposide Terbacil Testosterone cypionate Testosterone enanthate 2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) Tetracycline (internal use) Tetracyclines (internal use) Tetracycline hydrochloride (internal use) Thalidomide Thioguanme Tobacco smoke (primary) Tobramycin sulfate Toluene Triadimefon Tnazolam Tnbutyltin methacrylate Tnfonne Tnlostane Tnmethadione Tnmetrexate glucuronate 54965241 846504 29767202 5902512 58208 315377 1746016 60548 -- 64755 50351 154427 -- 49842071 108883 43121433 28911015 2155706 26644462 37273840 13647353 127480 82952645 Uracil mustard Urethane Urofollitropin 66751 51796 26995915 Valproate (Valproic acid) Vinblastine sulfate Vinclozolm Vincristine sulfate 99661 143679 50471448 2068782 Warfarin 81812 July 1, 1989 April 1, 1990 October 1, 1992 August 20, 1999 March 30 1999 January 1,1991 August 20, 1999 January 29, 1999 July 1, 1990 April 1, 1990 September 1,1996 May 18, 1999 October 1,1991 April 1, 1990 April 1, 1991 October 1, 1991 October 1, 1992 January 1,1991 July 1, 1987 July 1, 1990 April 1, 1988 July 1, 1990 January 1, 1991 March 30, 1999 April 1, 1990 December 1,1999 June 18, 1999 Apnl 1, 1990 January 1,1991 August 26,1997 January 1, 1992 October 1,1994 April 1, 1990 July 1, 1987 July 1, 1990 May 15, 1998 July 1, 1990 July 1, 1987 Female reoroductive toxicitv Aminoptenn Amiodarone hydrochloride Anabolic steroids 54626 19774824 -- July 1, 1987 August 26,1997 Apnl 1, 1990 15 ABDOOO19825 -16- Aspinn (NOTE It is especially important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery) 50782 Carbon disulfide Cidofovir Chtorsulfuron Clobetasol propionate Cocaine Cyclophosphamide (anhydrous) Cyclophosphamide (hydrated) 75150 113852372 64902723 25122467 50362 50180 6055192 o,p'-DDT p.p'-DDT Diflumsal Dinitrotoluene (technical grade) 789026 50293 22494424 -- Ethylene oxide Etodolac 75218 41340254 Flumsohde Flurbiprofen 3385033 5104494 Gemfibrozil Goserelin acetate 25812300 65807025 Halopendol 52868 Lead Leuprolide acetate Levonorgestrel implants -- 74381536 797637 Nifedipine 21829254 Oxydemeton methyl 301122 Paclitaxel Pimozide 33069624 2062784 Streptozocin (streptozotocin) Sulindac 18883664 38194502 Thiophanate methyl Tobacco smoke (pnmary) Tnadimefon 23564058 -- 43121433 Uracil mustard 66751 Male reoroductive toxicitv Altretamine Amiodarone hydrochloride Anabolic steroids 645056 19774824 ... July 1,1990 July 1, 1989 January 29, 1999 May 14, 1999 May 15, 1998 July 1,1989 January 1, 1989 January 1, 1989 May 15, 1998 May 15, 1998 January 29, 1999 August 20, 1999 February 27, 1987 August 20,1999 May 15, 1998 August 20, 1999 August 20,1999 August 26, 1997 January 29, 1999 February 27,1987 August 26,1997 May 15, 1998 January 29, 1999 November 6, 1998 August 26, 1997 August 20, 1999 August 20, 1999 January 29, 1999 May 18, 1999 April 1, 1988 March 30, 1999 January 1, 1992 August 20, 1999 August 26, 1997 April 1, 1990 16 ABDOOO19826 Benomyl Benzene Cadmium Carbon disulfide Cidofovir Chlorsulfuron Colchicine Cyclohexanol Cyclophosphamide (anhydrous) Cyclophosphamide (hydrated) 2.4- D butyric acid o, p'-DDT p. p'-DDT 1,2-Dibromo-3-chloropropane (DBCP) m-Dmitrobenzene o-Dimtrobenzene p-Dmitrobenzene 2.4- Dimtrotoluene 2,6-Dmitrotoluene Dimtrotoluene (technical grade) Dmoseb Doxorubicin hydrochloride Epichlorohydnn Ethylene dibromide Ethylene glycol monoethyl ether Ethylene glycol monomethyl ether Ethylene glycol monoethyl ether acetate Ethylene glycol monomethyl ether acetate Ganciclovir sodium Gemfibrozil Goserelm acetate Hexamethylphosphoramide Hydramethylnon Idarubicin hydrochloride Lead Leuprolide acetate Myclobutaml Nifedipine Nitrofurantoin Oxydemeton methyl Paclitaxel Quizalofop-ethyl Sodium fluoroacetate -17- 17804352 71432 -- 75150 113852372 64902723 64868 108930 50180 6055192 94826 789026 50293 96128 99650 528290 100254 121142 606202 ... 88857 23214928 106898 106934 110805 109864 111159 110496 82410320 25812300 65807025 680319 67485294 57852570 ... 74381536 88671890 21829254 67209 301122 33069624 76578148 62748 July 1, 1991 December 26,1997 May 1, 1997 July 1, 1989 January 29, 1999 May 14, 1999 October 1, 1992 November 6, 1998 January 1, 1989 January 1, 1989 June 18, 1999 May 15, 1998 May 15, 1998 February 27, 1987 July 1, 1990 July 1, 1990 July 1,1990 August 20, 1999 August 20, 1999 August 20, 1999 January 1, 1989 January 29, 1999 September 1, 1996 May 15, 1998 January 1, 1989 January 1, 1989 January 1, 1993 January 1, 1993 August 26, 1997 August 20, 1999 August 26, 1997 October 1, 1994 March 5, 1999 August 20, 1999 February 27, 1987 August 26, 1997 April 16, 1999 January 29, 1999 April 1, 1991 November 6, 1998 August 26, 1997 December 24, 1999 November 6, 1998 17 Streptozocin (streptozotocin) Sulfasalazine Thiophanate methyl Tobacco smoke (primary) Tnadimefon Uracil mustard Date June 2, 2000 ABDOOO19827 -18- 18883664 599791 23564058 -- 43121433 66751 August 20, 1999 January 29, 1999 May 18, 1999 Apnl 1, 1988 March 30, 1999 January 1,1992 18