Document nka3pYvRyKVMNJ9KoJprpywV2
CGU BEN0000865
CGU BEN0000866
CGU BEN0000867
CGU BEN0000868
CGU BEN0000869
CGU BEN0000870
CGU BEN0000871
CGU BEN0000872
CGU BEN0000873
Number Male
Female Mean age (SD) in years
Marital status- married
Education- None
Primary school
Middle school
High school University or higher
0
G)
~~ -Smokers (ever)
z
0
~ -Body mass index (SO)
~
722 1OO.OOo/o 406 56.23o/o 316 43.77% 49.92 (16.85) 605 83.80/o 57 7.89/o 137 18.98/o 227 31.44/o 183 25.35o/o 115 15.93/o 277 38.37/o 22.6 (3.3)
1444 100.00/o 812 56.23/o 632 43.77/o 49.98 (16.49) 1204 83.38o/o 60 4.16/o 199 13.78o/o 448 31.02o/o 393 27.22o/o 340 23.55o/o 508 35.18% 23.1 (3.7)
AML with current cytogenetic abnormalities (AML-RCA)
AML with t(8;21)(q22;q22),(AML1/ETO)
AML with inv(16)(p13q22) or t(16;16)(p13;q22),(CBE~/MYH11)
Acute promyelocytic leukemia (APL)
AML with 11 q23 (MLL) abnormalities
AML with multilineage dysplasia, with or without prior MDS (AML-MD)
AML and MDS, therapy related
AML not otherwise categorized (AML-noc)
AML, minimally differentiated
AML without maturation
0
G)
-c
I
OzmJ
0
0 0 0
(X)
-..J
01
AML with maturation Acute myelomonocytic leukemia Acute monoblastic and monocytic leukemia Acute erythroid leukemia
722 100.00!0 244 33.80!0 64 8.86/0 23 3.19/0 124 17.17!0 33 4.57/o 186 25.76!0
5 0.69%,
269 37.26!0 26 3.60/o 64 8.86%, 48 6.65%,
60 8.31%
42 5.82%)
AML-RCA APL AML-MD
0
G)
c
I
OzmJ
0 0 0 0
(X)
-..J
(j)
1'-..J
u u
1'-..J
fl
1'-..J
u
.1'-..J 1'-..J 1'-..J 1'-..J
u
1'-..J
1'-..J
~
1'-..J
t
1'-..J 1'-..J 1'-..J 1'-..J
fl 1'-..J
1'-..J
1'-..J
1'-..J
1'-..J
1'-..J
1'-..J
fl 1'-..J
AML-RCA
APL
AML-MD
-0
G)
c
I
OzmJ
0 0 0 0
(X)
-..J -..J
AML-noc
t ,...,
ft ,..., ft ft -
- -ft ,..., t
,..., fr fr fr fr
fr fr,..., ,...,
,...,
0
G)
c
AML-noc
I
OzmJ
0
0
0
0
(X)
-..J
(X)
1 (1.27-2.03)
(1.02-2.29) 1.22
(0.69-2.15)
(1.19-2.91)
(1.07-2.29)
1.52 (0.87-2.66)
(1.09-7.51)
(1.72-113.77) 0.73
(0.18-2.91) 1.22
(0.51-2.90)
2.50 (0.99-6.33)
5.99 (0.62-57 .52)
---
---
(1.21-18.05)
1 (1.22-3.64)
.
(1.07-8.43)
2.67 (0.60-11.91)
1.71 (0.58-5.1 0)
1~74
(0.76-3.96)
0
G)
c
AML-noc
I
OzmJ
0
0
0
0
(X)
c-...oJ
0.75 (0.29-1.92)
0.80 (0.16-4.12)
0.67 (0.07-6.41)
0.50 (0.06-4.47)
0.86 (0.22-3.32)
1.80 (0. 73-4.43)
1.20 (0.29-5.02)
0.67 (0.07-6.41)
2.67 (0.60-11.91)
2.00 (0.28-14.20)
(1.05-9.77)
3.00 (0.50-17 .93)
2.00 (0.13-31.97)
2.00 (0.40-9.91)
.....
1.93 (0.98-3.79)
2.80 (0 .89-8.81)
2.00 (0.58-6.91)
1.50 (0.34-6.70)
1~61
(0.58-4.49)
0
G)
c
AML-noc
I
OzmJ
0
0
0
0
(X)
(X)
0
(1.24-1.97)
(1.04-2.32) 1.21
(0.69-2.12)
(1.13-2.78)
(1.06-2.24)
1.75 (0.64-4.83)
1.00 (0.18-5.46)
---
8.00 (0.89-71.56)
0.67 (0.07-6.41)
1.40 (0.88-2.25)
(1.14-5.93)
2.33 (0.78-6.94)
0.75 (0.25-2.21)
1.22 (0.58-2.55)
(1.02-2.56)
(1.24-5.53) 2.11
(0.76-5.89) 1.18
(0.45-3.07) 1~ 13
(0.50-2.55)
AML-MD
I ..,.,_I~ "VV
zm
0 0 0 0
(X)
.(.X...).
1.50 (0.95-2.71)
2.50 (0.99-6.33)
1.67 (0.51-5.46)
1.65 (0.63-4.32)
0.79 (0.30-2.08)
(1.05-1.93)
(1.00-2.61) 1.95
(0.98-3.88) 1.16
(0.60-2.24) 1.38
(0.83-2.28)
2.00 (0.79-5.04)
3.33 (0.80-13.95)
1.33 (0.22-7.98)
2.00 (0.28-14.20)
0.50 (0.06-4.47)
1.44 (0.71-2.95)
2.00 (0.58-6.91)
1.00 (0.18-5.46)
2.00 (0.40-9.91)
0.80 (0.25-2.55)
AML-MD
I ..,.,_I~ "VV
zm
0 0 0 0
(X) (X)
1\J
1.16 (0.85-1.59)
1.16 (0.69-1.95)
1.17 (0.55-2.49)
0.92 (0.44-1.88)
1.35 (0.83-2.20)
1.07 (0.72-1.61)
0.91 (0. 76-2.07)
1.07 (0.44-2.64)
1.09 (0.41-2.87)
1.31 (0.68-2.51)
0.94 (0.39-2.25)
1.14 (0.34-3.90)
2.00 (0.28-14.20)
0.40 (0.05-3.42)
1.28 (0.24-6.99)
1.23 (0.81-1 .89)
0.83 (0.36-1.96)
0.79 (0.24-2.61)
0.75 (0.29-1.92)
(1.03-3.57)
AML-MD
I ..,.,_I~ "VV
zm
0 0 0 0
(X) (X) (...)
1.71
(0.93-3.16)
1 (1.12-8.65)
2.94 (0.95-9.1 0)
1.20 (0.29-5.02)
1.18 (0.45-3.07)
2.00 (0. 79-5.04)
3.33 (0.80-13.95)
2.67 (0.60-11.91)
1.50 (0.34-6.70)
1.00 (0.09-11.03)
(2.13-7.35) 2.44
(0.97-6.15) 1.40
(0.46-4.30)
(1.03-11.96)
(2.47-30.41)
(1'4 7-8 '34) 2.67
(0.60-11.91)
3.33
(0.80-13.95) 5.00
(0.97-25.77)
0
G)
c
AML-noc
I
OzmJ
0
0
0
0
(X)
(X)
~
(1.16-2.04) 1.44
(0.88-2.35) 1.26
(0.65-2.44) 1.39
(0.80-2.43)
(1.11-2.78)
1.83 (0.99-3.38)
1.94 (0.63-5.92)
---
2.68 (0.74-9.68)
1.46 (0.59-3.62)
'
(1.23-2.19)
1.61 (0.95-2.73)
1.41 (0.70-2.82)
1.34 (0.79-2.27)
(1.17-3I 03)
1 (1.09-4.39)
(1.21-18.05)
3.33 (0.80-13.95)
1.20 (0.29-5.02)
1~83 (0.63-5.29)
CGU BEN0000885
AML-RCA
AML with t(8;21)
APL
AML-MD
AML-noc 8c -
I
OzmJ
0 0 0 0
(X) (X) (j)
(1.19-2.08) 1.65
(0.97-2.80)
){
1.78 (0.85-3. 74)
(1.20-3.39) 1
(1.03-2.60)
0.68 (0.45-1.02)
~
~
){:
(0.18-0.99) 0
(1.19-3.35)
1.29 (0.97 -1. 73)
~
X
){:
~
AML-RCA
AML with t(8;21)
APL
AML-MD
AML-noc
0
G)
c
I
OzmJ
0 0 0 0
(X) (X)
-..J
1.29 (0.95-1. 76)
(1.18-3.09)
~
(1.01-4.00)
~
~
(1.18-1.85) 13
(1.13-2.36)
~
1.58 (0.95-2.62)
1 (1 .01-2.67)
~
1.36 (0.92-2.1 0)
){:
4.02 (0.76-21.22)
){
(1.07-5.03)
){
AML-RCA AML with t(8;21) APL AML-MD
0
G)
c
I
OzmJ
0 0 0 0
(X) (X) (X)
AML-noc
1.20 (0.84-1. 71)
1.37 (0. 76-2.50)
. (1.01-17.96) 1.85
(0.87..3.94) 0.95
(0.45-1.98) 0.99
(0.51-1.94)
~
2.34 (0.76-7.18)
~
~
~
~
~ ~ ~ ~ ~
0.17 (0.01-2.24)
AML-RCA
AML with t(8;21)
APL
AML-MD
,!
z
0 0 0 0
(X) (X)
c.o
AML-noc
(1.40-5.460
~ ~ ~ ~
(1.91-21.48)
2.39 (0.96-5.98)
~
~
~
2.89 (0.60-13.78)
3.86 (0.69-21.48)
~
~
0.18 (0.02-1.39)
~
0.55
(0.27-1.13)
~
Benzene exposure variable OR (95o/oCI) Ca Co
OR(95%CI
Ca Co
Ever/never
(1.05-1.93) 78 113
(1.00-2.61) 33 43
Length of exposed jobs Non;.exposed S10 years >10 to S20 years >20 years
Maximum exposure (EGS) Non-exposed EGS1 EGS2 EGS3&4
Decades of first exposure
Non-exposed
1940-1959
1960-1979
0
G)
11980-1999
Ic
I
2000-
OzmJ
0 0
Cumulative EGS-years
0
0
(X)
c.o
0
1.00 (0.98-1.02) 78 113 1.00 (0.97-1.03) 33 43
1.00 (reference)
644 1331
1.00 (reference)
211
445
.29-3.07) 43 45
(1.42-5.14) 23 18
1.44 (0.82-2.51)
21
30
1.01 (0.38-2.67)
6 13
0.74 (0.39-1.39) 14 38
0.71 (0.23-2.22)
4 12
P-trend=0.84
P-trend=0.89
(1.06-1.46) 78 113
(1.03-1.80) 33 43
1.00 (reference)
644 1331
1.00 (reference)
211
445
1.18 (0.79-1.76) 40 70 1.55 (0.86-2.79) 21 28
1.63 (0.90-2.94) 20 25
1.05 (0.39-2.82)
6 12
(1.05-3.98) 18 18
(1.00-15.99)
6
3
P-trend=0.01
P-trend=0.03
1.00 (reference)
644 1331
1.00 (reference)
211
445
1.33 (0.54-3.26) 8 12 2.97 (0.50-17.80)
3
2
0.97 (0.57-1.62)
22
46
0.90 (0.37-2.19)
7 16
(1.00-2.46)
36
49
1.44 (0.70-2.94)
14
22
(1.56-11.15)
12
6
(1.79-23A6)
9
3
1.01 (0.99-1.02) 78 113 1.01 (0.99-1.03) 33 43
P-trend=0.38
P-trend=0.56
Benzene exposure variable
Ever/never
Length of exposed jobs Non;.exposed S10 years >10 to S20 years >20 years
Maximum exposure (EGS) Non-exposed EGS1 EGS2 EGS3&4
Decades of first exposure
Non-exposed
1940-1959
1960-1979
0
G)
11980-1999
Ic
I
2000-
OzmJ
0 0
Cumulative EGS-years
0
0
(X)
.c....o..
0 (95o/oCI)
1.26 (0.56-2.83)
0.97 (0.90-1.04) 1.00 (reference) 2.17 (0.83-5.63)
---
0.50 (0.06-4.47) P-trend=0.33
1.36 (0.85-2.17) 1.00 (reference) 1.00 (0.37-2.74) 1.00 (0.37-2.74)
---
P-trend=0.20
1.00 (reference) 2.00 (0.50-17.80)
---
0.97 (0.25-3.81) (1.44-99.64)
1.01 (0.93-1.09) P-trend=0.85
Ca
10
10 54 9 0 1
10 54 6 2 2
54 1 0 3 6
10
Co OR (95o/oCI Ca
16 1.95 (0.98-3.88) 18
16 1.01 (0.97-1.05) 18
112 1.00 (reference) 106
8
(1.86-17.92)
13
4 0.89 (0.23-3.42) 3
4 0.67 (0.14-3.3) 2
P-trend=O.79
16 1.29 (0.88-1.89) 16
112 1.00 (reference) 106
12
(1.14-6.34)
13
4 0.69 (0.14-3.36)
2
0 2.00 (0.40-9.91)
3
P-trend=0.20
112 1.00 (reference) 106
1 --- 2
7 1.14 (0.34-3.90)
4
7 1.79 (0.69-4.61)
9
1 7.13 (0.72-70.61)
3
16 1.00 (0.98-1.03) 18 P-trend=0.85
Co
20
20 228 6 8 6
20 228 10 7 3
228 0 7 12 1
20
Benzene exposure variable
Ever/never
Length of exposed jobs Non;.exposed S10 years >10 to S20 years >20 years
Maximum exposure (EGS) Non-exposed EGS1 EGS2 EGS3&4
Decades of first exposure
Non-exposed
1940-1959
1960-1979
0
G)
11980-1999
Ic
I
2000-
OzmJ
0 0
Cumulative EGS-years
0
0
(X)
c.o
1\J
OR(95%CI)
1.16 (0.60-2.24)
0.99 (0.95-1.03) 1.00 (reference) .1.56 (0.64-3.81) 1.95 (0.63-6.09) 0.16 (0.02-1.39)
P-trend=0.59
1.22 (0.89-1.67) 1.00 (reference) 0.58 (0.21-1.65) 1.56 (0.47-5.15) 2.40 (0.73-7.86)
P-trend =0 .22
1.00 (reference)
-
0.66 (0.23-1.92) (1.18-8.87)
---
1.01 (0.98-1.03) P-trend=0.65
Ca Co
16 28
16 28 170 344 9 12 66 1 10
16 28 170 344 5 17 56 65
OR (95o/oCI
1.38 (0.83-2.28)
1.00 (0.98-1.03) 1.00 (reference) 1.35 (0.60-3.06) 2.00 (0.79-5.04) 1.02 (0.42-2.47)
P-trend=0.95
1.17 (0.91-1.50) 1.00 (reference) 1.08 (0.53-2.19) 2.58 (0.96-6.94) 1.22 (0.43-3.47)
P-trend=0.22
Ca
27
27 242 10 9 8
27 242 12 9 6
170 344
1.00 (reference)
242
0 4 1.69 (0.51-5.53) 5
5 14 1.28 (0.57-2.87) 10
11 8 1.07 (0.47-2.43) 9
0
2 5.99 (0.62-57.52)
3
16 28 1.00 (0.99-1.02) 27 P-trend=0.60
Co
40
40 498 15 9 16
40 498 23 7 10
498 6 16 17 1
40
CGU BEN0000893
CGU BEN0000894
Number
Male
Female
Mean age (SD) in years
Marital status- married
Education- None
Primary school
Middle school
High school
University or higher
0
G)
~~ -Smokers (ever)
z
0
; -Body mass index (SO)
01
649 1OO.OOo/o 392 60.40o/o 257 39.60% 52.5 (16.5) 546 84.13/o 50 7.70/o 140 21.57/o 218 33.59/o 134 20.65o/o 103 15.87/o 272 41.91/o 22.6 (3.48)
1298 100.00/o 784 60.40/o 514 39.60/o 52.7 (15.9) 1088 83.82o/o 78 6.01 /o 211 16.26o/o 399 30.74o/o 324 24.96o/o 281 21.65o/o 537 41.37% 22.8 (3.37)
NHLN-total (all subtypes) 8-cell neoplasms (all}
Precursor 8-cell neoplasms Mature B-cell neoplasms Chronic lymphocytic leukemia (CLL) Small lymphocytic lymphoma (SLL) Plasma cell myeloma Follicular lymphoma (FL) Diffuse large B-celllymphoma (DLBCL) T- and NK-cell neoplasms (all)
0
G)
I~. Precursor T-cell neoplasms
z
0
; Mature T-cell &NK-cell neoplasms (j)
649 100.00% 521 80.28/o 134 20.65% 387 59.63% 30 4.62% 37 5.70% 21 3.24% 45 6.93/o 186 28.66% 118 18.18% 31 4.78/o 87 13.41%
I .. .. ..... """-I
- - -y
"""' v
"""'
8-cell (all) Precursor B-cell
-H """'
u """'
--
- - -- -u ,.,..,
Mature 8-cell
- - -u """' ~
"""'
CLL/SLL
- - - - -"""' """'
- - - --FL """'
-
DLBCL u - - u - - -
I0
G)
c
T/NK-cell
I
u """'
-"""' """'
-"""'
OzmJ
0
0
0 0
(X)
c.o
fl (U) =significant increase (decrease); t (~)=borderline significant increase (decrease);- =no patter...
-..J
8-cell (all)
,...,
II
I I II
II
fl ,..., fl fl fl
Precursor 8-cell Mature 8-cell
t tfl,..., ,..., fl ,..., fl ft ft
CLL/SLL
,..., ,..., ,..., ,..., ,...,
FL
DLBCL
0
G)
c
T/NK-cell
I
OzmJ
0
0
0
0
(X)
c.o
(X)
,..., ,..., ,..., f'lotl f'lotl
fi ,..., fl fi fi
,..,
,..., ,..., f'lotl
,..,
B-cell neoplasms (all)
Precursor 8-cell neoplasms Mature B-cell neoplasms
CLL &SLL
FL
0.72 (0.48-1.08)
0.66 (0.42-1.03)
0.93 (0.37-2.33)
0.60 (0.36-1.00)
0.72 (0.23-2.27)
0.89 (0.27-2.89)
II~
OmJ
I~ T/NK-cell neoplasms
(O~ 16-0.94)
1.00 (0.38-2.66)
(1.14-1.78)
(1.19-1.96) 1.50
(0.89-2.25)
.
(1.15-2.04) 0.83
(0.40-1.74) 1.18
(0.53-2.50)
(1.24-2.76) 0.88
(0.50-1.50)
0.75 (0.39-1.46)
0.64 (0.29-1.42)
0.75 (0.20-2.83)
0.59 (0.22-1.60)
0.40 (0.05-3.42)
---
0.80 (0.16-4.12)
1.14 (0.34-3.90)
(1.95-7.76)
(1.81-8.25)
(2.77-46.66) 2.29
(0.90-5.81) 4.00
(0.36-44.11) 0.67
(0.07-6.41)
.
(1.1427.75) 8.00
(0.89-71.56)
8-cell neoplasms (all)
Precursor 8-cell neoplasms Mature B-cell neoplasms
CLL &SLL
1.60 (0.63-4.05)
1.75 (0.64-4.83)
8.00 (0.89-71.56)
0.86 (0.22-3.32)
---
FL
II~
OmJ
I~ T/NK-cell neoplasms
0.80 . (0~16-4.12)
1.00 (0.09-11.03)
1.67 (0.51-5.46)
1.33 (0.38-4.73)
0.67 (0.07-6.41)
2.00 (0.40-9.91)
---
0.60 (0.19-1.89)
0.88 (0.26-2.99)
4.00 (0 .36-44.11)
0.47 (0.09-2.35)
4.00 (0.36-44.11)
2.00 (0.28-14.20)
---
-----
1.54 (0.94-2.50)
.
(1.11-3.21) 1.25
(0.41-3.82) 1
(1.17-3 I 93) 0.80
(0.16-4.12)
(1.17-85.58) 1.75
(0.64-4.83) 0.57
(0.12-2.75)
8-cell neoplasms (all)
Precursor B-cell ..
neoplasms Mature B-cell neoplasms
CLL &SLL
FL
I~ ~-----
i IOmJ T/NK-cell neoplasms
(1.18-1.85)
(1.21-1.98) 1.49
(0.89-2.50)
1' (1.18-2.07)
0.88 (0.43-1.79)
1.26 (0.56-2.85)
..
. (1~33-2.98) 1.03
(0.59-1. 78)
1.
(1.01-2.97)
1.65 (0.90-3.07)
1.55 (0.51-4.69)
1.71 (0.82-3.58)
1.00 (0.18-5.46)
0.77 (0.13-4.48)
2.55 (0.80-8.14)
3.00 (0.85-1 0.63)
1.20 (0.44-3.30)
1.33 (0.48-3.75)
1.33 (0.22-7.98)
1.33 (0.38-4.73)
1.50 (0.34-6.70)
---
0.68 (0.35-1.32)
0.68 (0.31-1.48)
1.00 (0.09-11.03)
0.65 (0.29-1.48)
0.31 (0.07-1.44)
0.75 (0.20-2.83)
B-cell neoplasms (all)
Precursor 8-cell neoplasms Mature B-cell neoplasms
CLL &SLL
FL
II~
OmJ
I~ T/NK-cell neoplasms
1.15 (0.62-2.14)
1.22 (0.63-2.37)
(1.45-99.67) 0.73
(0.32-1.63) 1.20
(0.29-5.02) 4.00
(0.36-44.11) 0.36
. (0~08-1.64)
0.77 (0.13-4.48)
1.06 (0I 74-1.51 )
1.16 (0.77-1.73)
1.57 (0.63-3.94)
1.07 (0.68-1.69)
2.05 (0.79-5.32)
1.00 (0.30-3.32)
1.33 (0.38-4.73)
0.33 (0.04-2.77)
2.00 (0.13-31.97)
(1.45-33.70)
0.66 (0.31-1.42)
0.55 (0.23-1.33)
---
---
1.08 (0.43-3.32)
1.20 (0.44-3.30)
0.80 (0.25-2.55)
1.33 (0.27-7.98)
0.50 (0.06-4.47)
0.67 (0.07-6.41)
B-cell neoplasms (all)
Precursor 8-cell neoplasms Mature 8-cell neoplasms
CLL &SLL
FL
II0
G)
c
I
OzmJ
0 0
T/NK-cell neoplasms
0
0c.o
0
(...)
1115 (0.80-1164)
1.06 (0 I 70-1160)
1.32 (0.50-3116)
1.00 (0163-1160)
1171 (0163-1160)
(1137-31.76) 0167
. (0~31-1148)
1123 (0157-2165)
1128 (0183-1196)
1.25 (0176-2107)
1.12 (0 136-3149)
1129 (0173-2126)
1134 (0 137-2126)
[6 cases vsl 0 control]
0176 (0131-1189}
1107 (0145-2157)
0157 (0119-1 I 74)
0.62 (0120-1189)
---
0146 (0113-1162)
1100 (0109-11103)
---
---
---
1111 (0168-1182)
1.09 (0161-1195)
1.00 (0129-3150)
1112 (0156-21160)
1177 (0150-6124)
1162 (0131-8140)
0150 (0111-2136)
1117 (0146-2196)
B-cell neoplasms (all)
Precursor B-cell ..
neoplasms
Mature B-cell neoplasms
CLL &SLL
FL
I DLBCL
0
IIG)
c
I
OzmJ
0 0
T/NK-cell neoplasms
0
0c.o
0
~
0.79 (0.35-1.83)
0.93 (0.38-2.29)
2.67 (0.60-11.91)
0.50 (0.14-1.77)
1.00 (0.18-5.46)
2.00 (0.13-31.97)
---
---
0.91 (0.32-2.62)
1.00 (0.34-2.93)
2.00 (0.13-31.97)
0.89 (0.27-2.89)
4.00 (0.36-44.11)
4.00 (0.36-44.11)
--
---
'1 (1.11-4I 40)
(1.08-5.67) 6.61
(0.72-60.86) 2.00
(0.79-5.04) 2.00
(0.13-31.97) 2.00
(0.13-31.97)
(1.03-11.96)
1.55
(0.43-5.58)
2.00 (0.50-8.00)
2.00 (0.40-9.91)
1.33 (0.22-7.98)
2.00 (0.13-31.97)
2.00 (0.13-31.97)
8-cell neoplasms (all)
Precursor B-cell neoplasms
Mature B-cell neoplasms
CLL &SLL
FL
DLBCL
0
G)
c
I II
OzmJ
0
0
T/NK-cell
0
0c.o
0
neoplasms
01
(1.22-2.07)
.
(1.39-2.49)
.
(1.04-3.68) .
(1.32-2.55) 1.76
(0. 76-4.08) 1.64
(0.62-4.34)
. (1..28-3.19)
0.57 (0.27-1.19)
(1.02-3.05)
(1.05-3.73) 0.57
(0.12-2.75)
(1.33-5.82)
---
---
(1.07-8.43) 1.00
(0.30-3.32)
(1.17-2.00)
(1.25-2.27) 1.62
(0.83-3.17)
(1.22-2.37) 1.51
(0.63-3.64) 0.84
(0.30-2.34)
(1.27-3.06) 0.74
(0.36-1.51)
CGU BEN0000906
B-cell neoplasms (all) Precursor B-cell neoplasms Mature B-cell neoplasms
CLL &SLL
FL
DLBCL
im .I~-
OJ
5 T/ NK-cell neoplasms
(0.35-0.85)
(0.36-0.97)
~
0.66 (0.38-1.14)
2.75 (0.82-9.24)
~
(0.08-0.70) 0.38
(0.11-1.27)
1
(1.05-2.05)
1.16
(1.08-2.30)
){:
1 (1.23-2.80)
1.96 (0.74-5.17)
X
(1.06~3.44)
~
(1.01-1.65) 1.26
(0.96-1.65)
){:
~
X
X
)-{:
1.47 (0.84-2.60)
8-cell neoplasms (all) Precursor 8-cell neoplasms Mature 8-cell neoplasms
CLL &SLL
FL
DLBCL
im .I~-
OJ
5 T/ NK-cell neoplasms
(1.19-4.56)
(1.78-8.92)
(2.97-204.02) 2.19
(0.84-5. 71) 6.41
(0.55-75.22)
~
. (1.0528.44) 6.40
(0.69-59.25)
~
~
~
~
0.41 (0.12-1.36)
~
(1.36~25.98)
~
1.39 (0.94-1. 79)
1.69 (0.97-4.70)
2.13 (0.97-4.70)
(1.15-2.39) 2.97
(0. 73-12.09)
~
)-{:
'
(0.13-0.86)
8-cell neoplasms (all)
Precursor B-cell neoplasms
Mature B-cell neoplasms
CLL &SLL
FL
DLBCL
0
G)
c
I II
OzmJ
0
0
T/NK-cell
0
0c.o 0c.o
neoplasms
0.62 (0.35-1.1 0)
0.77 (0.42-1.42)
0.88 (0.28-2. 75)
0.60 (0.29-1.26)
1.64 (0.58-4.67)
(1.45-33.70) 0.56
(0.23-1.34) 0.33
(0.09-1.22)
~ ~
(1.78-212.90)
~ ~ ~ ~ ~
1 (1.02-4.55)
2.13 (0.88-5.15)
~
1.95 (0.73-5.22)
~
~
3.50 (0.93-13.11)
2.72 (0.62-11.97)
Benzene exposure variable OR (95%CI)
Co OR (95%CI
Ever/never
Length .of exposed jobs Non-exposed S:10 years >10 to S:20 years >20 years
Maximum exposure (EGS) Non-exposed EGS1 EGS2 EGS3&4
Decades of first exposure
Non-exposed
1940-1959
0 1960-1979
G)
c 11980-1999
I
IOzmJ 2000-
0
0
0
.0c...o..
Cumulative EGS-years
0
1.06 (0.74-1.51)
1.00 (0.98-1.02) 1.00 (reference) 1.12 (0.87-1.85) 0.88 (0.43-1.83) 1.12 (0.59-2.11)
P-trend=0.80
1.03 (0.85-1.26) 1.00 (reference) 1.14 (0.73-1.78) 0.75 (0.35-1.64) 1.21 (0.53-2.76)
P-trend=0.76
1.00 (reference) 0.69 (024-2.01) 1.37 (0.83-2.26) 095 (0.51-1.77) 0.67 (0.18-2.46)
1.01 (0.99-1.02) P-trend=0.36
50 95
50 95 599 1203 24 43 11 25 15 27
50 95 599 1203 32 56 9 24 9 15
599 1203
5 14
27 40 15 32
39
50 95
1.16 (0.77-1.73)
1.00 (0.98-1.03) 1.00 (reference) 1.29 (0.73-2.26) 0.90 (0.38-2.14) 1.15 (0.56-2.37) P-trend=0.78
1.1 0 (0.89-1.37) 1.00 (reference) 1.18 (0.70-2.00) 0.80 (0.35-1.85) 1.64 (0.68-3.97) P-trend=0.37
1.00 (reference) 0.88 (0.26-2.98) 1.51 (0.83-2.73) 0.98 (0.50-1.93) 0.86 (0.22-3.32)
1.01 (0.99-1.03) P-trend=0.23
Ca Co
40 70
40 70 481 972 20 31 8 18 12 21
40 70 481 972 23 39 8 20 9 11
481 972 49 20 27 13 27 37
40 70
Benzene exposure variable OR (95%CI)
Co OR(95%CI Ca Co
Ever/never
length of exposed jobs
Non~exposed
~10 years >1 0to S20 years >20 years
Maximum exposure (EGS) Non-exposed EGS1 EGS2 EGS3&4
Decades of first exposure Non-exposed 1940-1959
0 11960-1979
G)
c 1980-1999
I
OzmJ 2000-
10
0
0
..0c.......o....
Cumulative EGS-years
1.07 (0.68-1 .69)
31
58 7.00 (1.45-33.70)
7
2
1.00 (0.98~1.03)
31
58
1.42 (0.76~2.67)
7
2
1~00 (reference) 356 716
1.00 (reference)
38
88
1.12 (0.58~2.16)
19
31
1.00 (0.09~11.03)
1
2
1.01 (0.39-2.61) 5 18
---
10
1.06 (0.49~2.31)
7
9
~--
50
P-trend=0.79
P-trend=0.27
1.04 (0.82-1.33)
31
58
2.1 0 (0.90-4.52)
1.00 (reference) 356 716
1.121(0.68-2. 16)
19
31
1.00 (reference)
---
0.57 (0.21-1.52) 5 18 2.00 (0.13-31.98)
1.57 (0.49-2.31)
7
9 2.00 (0. 13-31.98)
P-trend=0.74
P-trend=0.09
7 38 5
1 1
2 88 0 1 1
1.00 (reference) 356 716
1.00 (reference)
38
88
1.00 (029-3.50) 4 8
---
00
1.59 (0.84-3.01) 18 23
---
60
o~82 (0.36-1 .87) 8 20 2.00 (0.13-31.98) 1 1
0.29 (0.04-2.32)
1
7
01
1.01 (0.99-1.02)
31
58 1.26 (0.24-31.09)
7
2
P-trend=0.35
P-trend=0.47
CGU BEN0000912
CGU BEN0000913
CGU BEN0000914
CGU BEN0000915