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TOXICITY of.......VINYL CHLORIDE, POLYVINYL CHLORIDE and STRUCTURAL ANALOGUES -- March 20 -21,1980 NATIONAL INSTITUTES Of HEALTH MASUR AUDITORIUM BUILDING 10 CLINICAL CENTER BETHESOA, MARYLAND R&S 141413 National Inatttutas of Enviramnontal Health Sciences National Institute for Occupational Safety and Health Occupational Safety and Health Administration -I CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE, POLYVINYL CHLORIDE AND STRUCTURAL ANALOGUES March 20-21,1980 National Institutes of Health Masur Auditorium Building 10 Clinical Center Bethesda, Maryland 1 t*' 1 V Cosponsors National Institutes of Environmental Health Sciences National Institute for Occupastional Safety and Health Occupational Safety and Health Administration 1 R&S 141414 Thursday, March 20,1980 8:00 A.M, REGISTRATION 8:30 A.M. INTRODUCTORY REMARKS Dr. David Rail, NIEHS SESSION I - 8:45 A.M. 9:45 A.M. 10:00 A.M. 10:15 A.M. 10:45 A.M. 11:00 A.M. 11:15 A.M. CARCINOGENESIS BIOASSAYS OF VINYL CHLORIDE MONOMER Chairperson: Dr. Umberto Saffiotti, NCI 1. Carcinogenicity Bioassays of Vinyl Chloride Monomer: A Model of Risk Assessment on Experimental Basis Dr. Cesare Maltoni, Institute of Oncology and Tumor Center, Bologna 2. Experimentally Induced Pulmonary Cancer Dr. Y. Suzuki, Mt. Sinai Medical School Discussion Break 3. The Role of Aging on Cancer Induced by Vinyl Chloride Monomer Dr, David Groth, NIOSH 4. Carcinogenic Effects of Exposure to Vinyl Chloride Monomer and Ethyl Alocohol on Rats Dr. Martha Radike, University of Cincinnati 5. Cancer Induction Following Single and Multiple Exposures to a Constant Amount of Vinyl Choride Monomer Dr. Robert Hehir, CPSC SESSION II 11:30 A.M. 11:45 A.M. TOXICOLOGY STUDIES OF POLYVINYL CHLORIDE Chairperson: Dr. Peter Infante, OSHA 6. Pneumoconiosis in Animals Exposed to Polyvinyl Chloride Dust Dr. David Groth, NIOSH 7. Results of Carcinogenesis Bioassay of Polyvinyl Chloride Dr. Chris Wagner, BMRC, Penarth, Wales f | i l R&S 141415 Thursday, March 20,1980 SESSION III -- SPUTUM CYTOLOGY OF VINYL CHLORIDE WORKERS Chairperson: Dr. Peter Infante, OSHA 12:00 P.M, 8. Results of Sputum Cytology Among Workers Exposed to Vinyl Chloride Monomer and to Polyvinly Chloride Dr. Cesare Maltoni, Institute of Oncology and Tumor Center, Bologna 12:15 PM. Discussion 12:30 P.M. LUNCH SESSION IV -- MORTALITY STUDIES OF WORKERS EXPOSED TO VINYL CHLORIDE Chairperson: Dr. Philip Landrigan, NIOSH 2:00 P.M. 9. Multiple Site Risk Analysis of Vinyl Chloride Related Cancer in Workers -- Review Dr. Peter Infante, OSHA 2:15 P.M. 10. .Cohort Mortality Study of Vinyl Chloride Workers Dr. H. Weber, Der Staatliche Gewerbearzt Fed. Republic Germany 2:30 P.M. 11. Epidemiological Study of Vinyl Chloride Workers Dr. Clark Cooper, Consultant 2:45 P.M. 12. Power Considerations in Epidemiologic Studies of Vinyl Chloride Workers Dr. Jay Beaumont, NIOSH 3:00 P.M. Discussion 3:15 P.M. Break SESSION V 3:45 P.M. LIVER AND BIOCHEMICAL CHANGES ASSOCIATED WITH VINYL CHLORIDE Chairperson: Dr, David Groth, NIOSH 13. Epidemiologic Review of Hepatic Angiosarcoma in the United States Dr. Henry Falk, CDC Thursday, March 20,1980 4:00 PM. 4:15 P.M. 4:30 PM. 14. United Kingdom Angiosarcoma Registry Dr. Peter Baxter, CDC 15. Pathology of Vinyl Chloride Induced Liver Lesions Dr. Hans Popper, Mt. Sinai Medical School 16. Liver Screening Tests for Vinyl Chloride Exposed Workers Dr. Carlo Tamburro, University of Louisville SESSION VI - INDUSTRIAL HYGIENE MEASUREMENTS OF POLYVINYL CHLORIDE OPERATIONS Chairperson: Mr. James Gideon, NIOSH 4:45 P.M. 17. Polyvinly Chloride Processes and Products Dr. R. Nick Wheeler, Union Carbide 5:00 PM. 18. Characterization of Polyvinyl Chloride Homopolymers, Copolymers and Additives Mr. Jay Jones, NIOSH 5:15 P.M. Discussion Friday, March 21,1980 SESSION VII - MORBIDITY AND MORTALITY STUDIES OF WORKERS EXPOSED TO POLYVINYL CHLORIDE Chairperson: Dr. R. Greenberg, University of Louisville 8:30 AM. 19. Mortality Among Polyvinyl Chloride Fabricators Dr. Leonard Chiazze, Georgetown University 8:45 AM. 20. Heart Disease in the Swedish Polyvinyl Chloride Fabricating Industry Dr. Gustavo Molina, Colombia 9:00 AM. 21. An Epidemiological Study of Respiratory Disease in United Kingdom Workers Exposed to Polyvinyl Chloride Dust Dr. Anthony Seaton, University of Edinburg 9:15 AM. 22. Pneumoconiosis Induced by Polyvinyl Chloride Dust Dr. A. Arnaud, Marseille, France 9:30 A.M. 9:45 A.M. 10:00 A.M. 10:15A.M. 10:30 A.M. 23. An Epidemiologic Study of Pneumoconiosis in the Italian Polyvinyl Chloride Industry Dr. Guiseppe Mastrangeio, Padova, Italy 24. A Case-Control Study of Lung Cancer Among Vinyl Chloride-Polyvinyl Chloride Workers Dr. Richard Waxweiler, NIOSH 25. Review of Pulmonary Effects of Polyvinyl Chloride Exposure Dn Ruth Lilis, Mtj Sinai Medical School Discussion Break SESSION VIM 11:00 A.M. REPRODUCTIVE EFFECTS OF VINYL CHLORIDE Chairperson: Dr. James Wilson, University of Cincinnati 26. Transplacental Teratogenic Effects of Vinyl Chloride in Experimental Animals Dr. Jackie John, Dow Midland . -- . 11:15 A.M. 274 Transplacental Gareinogcnic-Effects Dr. Jerry Rice, NCI V 11:30 A.M. 28. Mutagenic Effects of Vinyl Chloride Dr. Jill Fabricant, University of Texas, Galveston 11:45 A.M. 29. Power Considerations in Studies of Reproductive Effects Associated with Vinyl Chloride and Some Structural Analogues Ms. Maureen Hatch, Columbia University 12:00 P.M. Discussion 12:30 P.M. LUNCH SESSION IX - ENVIRONMENTAL EXPOSURE TO VINYL CHLORIDE POLYVINYL CHLORIDE AND LIVER ANGIOSARCOMA Chairperson: Dr. Pier Bertazzi, Institute of Occupational Health, Milan Friday, March 21,1980 2:00 PM. 2:16 PM. 30. Fugitive Emissions of Vinyl Chloride-Polyvinyl Chloride Or. Susan R. Wyatt, EPA 31. Case-Control Study of Liver Angiosarcoma Among Residents in New York Dr. Nicholas Vienna, N.YJS. Department of Health j * \ SESSION X - 2:30 PM. 2:45 P.M. 3:00 PM. 3:15 PM. 3:30 P.M. CARCINOGENICITY OF SOME STRUCTURAL ANALOGUES OF VINYL CHLORIDE Chairperson: Dr. Kim Hooper, University of California, Berkeley 32. Comparative Pathology of Vinyl Chloride and Vinyl Bromide Induced Liver Pathology in Animals Dr. William Busey, Experimental Pathology Laboratories 33. Review of Experimental Carcinogenesis of Vinyl Chloride Related Compounds Dr. Ken Chu, NCI 34. Review of Epidemiologic Study Results of Vinyl Chloride Related Compounds Ms. Rosanne Apfeldorf, OSHA Discussion Break SESSION XI - RESEARCH NEEDS AND PUBLC HEALTH INTERVENTION Chairperson: Dr. Anthony Robbins, NIOSH Pane/ Discussion: 4:00 P.M. 35. Dr Dale Haddis, Center for Policy Alternatives, MIT 4:15 P.M. 36. Mr. Steve Wodka, OCAW 4:30 P.M. 37. Dr. Maurice Johnson, B.F. Goodrich 4:45 PM. 38. Dr. Irving Selikoff, Mt. Sinai Medical School i i A .i R&S 141419 Friday, March 21,1980 6:00 PM. 5:15 P.M. 39. Or. Joseph Wagoner, EOF Discussion Proceedings from the Conference will be published Program Planning Committee Or. Richard B. Everson NIEHS, Research Triangle Park, North Carolina Dr. Peter F. Infante OSHA, Washington, D.C. Dr. Philip J. Landrigan NIOSH, Cincinnati, Ohio Dr. Raymond E. Shapiro NIEHS, Research Triangle Park, North Carolina Dr. Richard J.Waxweiler NIOSH, Cincinnati, Ohio j* I R&S 141420