Document nkOR0RrN4ee8RwGKBRbXYO11X

JP'll<OJJJ!E.<CT AN!lll ll.l.lJ][ l!l>IF &JP'n' IBlJEp,f?lJ&~IE 'li'A~ lFOlFl.<CE (August 5, 1997) I llmntl! I ItComfllrilctm l?'oo.illl!::~$11!1!1lilte/ ~- Medlanism of Benzene Induced Lealamia Rlchard Irons (Wayne Stillman, David Ross) University of Colorado Validation experimeot on CP colony forming uni!S successful in showing qt!aliwive a!X:UliCJ of 3BRA predictions. ($200.1() Nillllre of flow cytometry subgroup$. BTF ccmrnents sougbt on manuscript about diagnostic value ofMPO activity for leukemia type. Bi~logically-Based Ri!!c IUsessme!tl (BRRA)Modd Tony Cox Colt A550Ciates (li64K from 1996) 1996-7 projects: 0 GeooiOxicity module; 0 Analysis of da!a fri)lll validation expuiment underway; 0 Draft manoscripton validation ofBBRA. Pro bono woJ!< on non-futear mmuscript (Thomas/EBSO l A:IIOOnn llli:!lJIJD ~lhrom '1/fi.flfl~ I MBPdraftleuer for PB'& sigllature: 0 Start ~ruing meul!olism in 5-Us. with empbasis on biological significance; 0 Stut investigatioo of differences in Imeubolism & swsilivicy between non-smolrers &smo!r.m; 0 Reqoest quarterly reports /k. enooUfliJl_e~blicalion. TC: Write up CP BBRA for publication & prepare to share wilh oiher-modelets. MBP: .Amnge wOIIOOop of modelf.rs w assess CP BBRA moc!el in conj1nction with SRA meeting in BaltimOte, Thurs., Dec. 11. Bncourage clinical vzlidatioo. MeWiolism Rogeoe Henders<Jn (Bill Bechtold) ITRI ($!26KbaW!cefrom 1996) Rc--establislled GCIMS mt l:bod. In June/July dete.nniru:d thai use of 3 derivilization metbuds necessa;:y to cover metabolila ofiniest. Gene!llle standard curves in July/Aug~st; to be followed lly Baldwin audit. Chuck Ross: PIJm S)llllpotYUDl at A.COOM fo~aie..J>.hysieian< Monitor progress regularly (biweekly amfen:nre caDs) Judy 6alclwin aVllilable or audii of sLmldardcurves on August6-7 in 0011junclion wilh CMA BD visit. Futalize protnml for exposures lllllposure ai -60 JIIPdl ll!xoosure at- 6 IOODI, wi!b COillllllletion bv Oc1ober 1997 Sdleclult site visit 10 OK protocOl for animal swdy (S~'!) N l.&:l ~ ;";":' ..., ~ iiJ I> X vI BP-00017704 Cimltoxicity GaryWilllams (John Whysoer) American Health f'oundalion (li92K) Gino Scarano ll.SI (S36K from 1995) Exposure of Pli~f!lm Cohort (legslregs) Chinese Epidemiology Study Denis Paus~eobacb (Paul Price) CbemRis.k (SI2.5K) Compilaltion of Benzelle Monitoring Levels DynCotp witb oversight by IH'IF Worftsllop on BenllCI!Ie Re3earcb Stmte!l!v f!.IJro!llliUI Community Coottact signed in Julie. 7n9 Table of DNA adduct studies recieved. bReview of geno10xicity tileralllre on btnzeoe (a) Pllase I: DNA reactivity and adduct formation Litetatwe search for all metabolites initialed - 9-J31. (b) Pllase IT: Mutal!ellicitv and clastol!ellititv eudtminU -Beozeoe case study (along with BDarul VC) or bow nontumor data oouldfsbould be used in cancer risk assessment Outline exJK'Cied from llew.eoe team of Martyn Smidl, Rich Irons, and R1ly Tice in July, with draft report in fall 1997. Outline for PiiiJ\7 received. (CbemR.isk bas decided 10 undertat<e a more comJH'ebensive Monte Caclo analysis, covering expenses above amtract amoun~lhemselvcs.) July 1997 JNCI publication on NCI stndy snworts ben1ene -associated wilb neoplasms other than AML, but still no ris.k estimates. Question: (1) accuracy of case diagnosis, (2) bow low bcazene e!<pOSUre estimstes; (3) wlletber coofounding exposures. 2114197: MBP learn if NCI bas SAil 418197 oonr. call: 0 As.k Rotheman to next D.C. BTF meeting; 0 RS diaft l.i$1 of qaestions. Repor~ rereived documenting derivation and cooteniS of databaie witll. appendices JH'cScoling analyses requested by IHTP; aa:eptability as final version will be delemlinedat July 15 BTF meeting. Delivery of e1eawoic datablllse e~ ahordy for use by B'Illmemhm. Similar to Airlie WS, Falll992. Aim for Summer 1!198. SWK!Diat}' prql8l'eCI focCON'CAWBby EBSI delivered to Gc:nnan m~ ill Mr.y 1996. Adaped risk assessment expected tn be fioal in fall of 1997. Use worlr ofQu I Chen of NYU for HEI to validate biomaritetS-i:.-separate Chinesoe study to ciLallenlle NCI expo es~ AJ: Have DyoCorp oom:ct text wilh IEl:U<mio problem & provide BTF epideoliologi&l:l wiih e!eclronic form of databue fOI' approval. Feel out? atE!>A {CH) arul llU'ewslti at Healih Canada (GG) for co-su111DJ1 a:! tl1 c .~... .... .".. 0J "X ------ -- BP-00017705 U.S. EPA AEGL& - Priority Chemicals List U.S. EPA California North Carolina May 21, 1997, Federal Register 110lice tlult btlnzeoe among 1!5 cheJnicals 011 priority list for detennination ofaate erposure guideline (AEGL); request for daJa or other info. Julian Preston ($4.5K) June 30. 15197, Federal Registt!P'Doti.ce ofrcleasefor enfrnal reviewofNCEA"s revision of EPA's 1985 JllltciiCy Vijay Reddy (SlK} factar as equeslfld b}'-Oime of Molrilc Source in c~Gtie.'l wi4h CAAA ill l992 External Review Panel named (Rob Schnata:r one of siX IIICIIlbtn) in June 1997 with wDibhop to be held July 16 andpublic written COIJIIMRIS due August 29. Meeting on July 2 at BBSI to initiate comments. Vijay Reddy and Juli.m Preston under contraCt to write pieces 011 relalive sensitivity of DNA-adduct teehniQllf$ and non linearilies associated with gcnotoxic~ndpoints other dian _j)Oint muWion. WSPA requestill! review from CARB; OEHA then makes decision whether !0 do n:view State SAB lead by George Lucier proo11cing RICs and RIDs for benzeDe and numerous other subSWtces tllal ue finding their way into DOilMC decisioo-malring, e.g., New Jersey Sapt:rf'urul site evaluations U.S. EPA initi.ally (Febrwuy 1997) expressed concern, but ball dooe niJibillg.siace-~iteJ>rOOding. PB giving 2-3 minute statement for API at 1/16 EPA WS. Schedule far API CQlllllll:lll.8: IllS API outline (PB. RS, MBP) 817 conference call 8J II drafts li:om API(??), PrestoJt, Reddy 8/14 conference call 8/IS fmal from Preston & Reddy 8120 API final to g=n slip 8!22 API submission (MBP & PB gone) [S/29 official de..tlineJ Let it go? I v BP-00017706 -> Zlo SB6 831~ D. STR~THER Fax to Mmry Paxton at 202-682-8270: S/fltJ/1!/C (full name) (company) can participate in the fffim BTF conference emil on Thunmllmy, .&~ Z, m!t 3:~ IWIWir; A better time this week would be: can participate in the ~01llldl B"'"F conference caU on Th~y, A~~ ma 31:!1];3] ~lill'f; A better time that week would be: You will be notified if a-~ from these two times is cecessary. Tnparticipate, cmll-800-282-2343 at the-appointed time. would like a copy of the Canadian exposure report. BP-00017707 . - - - - - - - - - - - - - rp-----------~----------------------------------------------------------------------- 11:11 -> 21~ 58~ 831~ D. STROT~ER Page 001 VIA FAX TO: S~fROTHER, DALE E. BP AMERICA FROM: ATTN: DALE STROTHER TO: FAX PHONE#: 216-586-8314 Job Number: 66328762-009-27-0004 TIME: Tue Aug 05 11: 55:.43 1997 8 pages including cover sheet BP-00017708 ,.... 11:11 ~; 68/6Sf97 11:5&:35 Yia Fax -> ZlG 58& 831~ D. STROTHER ~= August 5, 1997 "'_ / 0Mary Pax~(.(v v fli!D@ffifij@ Benzene Task Force (BTF) ~e: l?roject updates and action items since July 14-15 meetings I Comments on EPA's revision on benzene's cancer potency I Exposure issues Atmched is an update of our projects and issues table with action items reflecting what transpired at oot: site visit with Rich lirons and Tony Cox and our BTF meeting the neJ~.t day: Our most pressing current item is preparation of comments for submission to EPA regardi11g its re~valumoXll dOt;UIDf:nt on bmzene's carcinogenic potential. We have contracted with Vijay Reddy mel .Julim lPlreston to write pieces on the relative sensitivities of various techniques for detecting DNA adducts and on oon-JineM.ties to be expected with specic sort.s of gcnotoxic endpoints, respectively. We arc c~ng drafts next Mlwday, August 11. We will need to generate comments quickly.._so they can produce revised fi!li!ll versions over the following wee!cend fur Monday, August 18. We have to finalize our comments and "green-slip'' them fur signoff withjn AIPI by Friday, Augustll, because Pat and I have commitments elsewhere the-next weetc. (M anyone wants to volunteer-to oversee submission on August 2~, the official deadline, they are ~ than welcome to assame the responsibility and thereby ea."'e up the schccMe.) mWe-should check very soon that we're Olrthe right track <Mid have all the imporuwt bases covered a conference call. I suggest that we review these matters on this Thursday. August 7, at 3:00 ElDST. 1'o review om consultants work and go over our own product we1>howd schedule another fur tbe next week, too. Elow about ThUIIiday. August 14, at 3:00 ESJDT? Plea.o;e respond as to your availability atJJne~ times. On Older' to facilitate your scheduling this call, I am not holding this memo for our waft outline; it will be fued by tomorrow for yOW' consideration prior to the tim-call.) Also att!i!ched are the cover page and table Of contents from a 90-report Canadil!lD report on balzenc expos~ in upstt"e8m oil and gas production. ff youd like-a copy, plecnsc so indiccnte en the i'CSJPODSe fonn. Along similar liDes. does 'l!llyone have any input for OynCorp on the-d!ocument on benzene levels wiihift ow industry? Fmalization of that project is targeted for the end of the summer, so I need to receive lll1lly comments immediarely. BP-00017709 \..; ... ..... 58/95/~7 11:59!13 Via Fax -> 216 586 8314 D. STROTHER Pdwe 6~? (.y-((j.q ~ ~ ~ M~Mas~~r . . Oc~u pa 6 ti on a l and sPI s I Y{'(Jt e;Jtri~c.~.~ Unsversity ~~:;:_..:,~<;;~:- Envtronmental Health Laboratory ~,t~ ()"1~n~Q..k. ;.~U 12001\ilain Stm!tWast. HSC 3H58 ~- ~Tel: (S05)525-g14(J, .go ' Hamilton. Ontario. L8N 32:5, CmMSI Fax; (205) 528-0060 [LW~~Dif' [Rj@WOW il ~l!~Mtr ~@ ~@!filiZITD@ Ollt9J ulifi [}{]wJrrU'!Q)(Q)[il)@ ouu mru lLD~@~[JIfiTi) no mJ@ @~ UITil@M~rfW ~:urucQJ ir[)=u ltnfQnw[l'D JfJ ~~MU' @[Jl)~!f@O ~~rr@U@O IC\\9" i1t. \1'ITifl! fl~JDto ~.lEn~ . C~~, ~0~ ~!PililillHI,Q)~ ~lillW~~~Ror) DuM ~- Jin~ll10 ~.$C. A J~t !Rtoow~ru !R!~rt !fi>!l@~~ ii@li': ~lru~~U/IDfil ~fffilrrl f ~Rm~@(!,Bffl I?IIOOflJJro ~~~~~o ~~~IIDi1f0 ~lQ)ult@ CW~ Prjd ~oorJon~~lf: J.[Q). {Jam) IMtllLM IQ)~ ~~lffr WIWumOOr ~ ~o il ~00 .. -..........-.. BP-00017710 i. ;; --; .. - ~ saiBS/97 11:59:46 Via Fax -> 21& 58& 831~ D. STROTHER Page 6!BJB IJL@u= ~IF 00~ ~. A~ . . . . . . . . . . . . . . . . ~ ~ DN"i"ROEI1Jel'!ON ~ ~- DIE~I~Ii\! OF UJ~ UM::II.J$'WN' ~K) ~A{)~~g@ . o o @ 3..1 ~~alb/~ ................. "............................ @ uro~~~ ................................................. 3..3 M~W Ul ~~OCIESS!NG ............ - - . - - . -- -- .. .. - 'il~ 3.4l- T~ ~gs ...................................... ., . . . . . . . . . . . . . . . . . . . . . . . . . . . . cg<ij 3.5 OOWNG ........ o o o '\1~ 3.~ 1?'111?6.!1NIE . . . . . . . . . . . . . - - . - - 'ii.Z 3.7 ~~~'YVOO ' .................................................... D 0 0 'll@ <$. ~$U~~ ~li:\ilfS . . 0 '\li' <S. 'I ~RAN COM~ANie$- . . . . . . . . . . . . . . . 'ill' <S.2 O'i1i~ ~~ISNCI$S . . . . . . 'i S. ~N\IIRONM~N'i'AL IMP'UCATIONS ............... <00 0.......5.11 G6V006 !)EH'fDRAiORS ...... (J'!I 3. 8~1EN1"1R~DDON ..:MID IPRIQRmY\iiON 0? DA'i'A ~S ........... , <::!@ IIi.~ 0/:\"ii"~S ............ fS.2! 19AYA~ MOYND OCCIJI"'Al'l~ ~~a,m~ M~YRI5Msl\mi . . . @.~ 1'\f'PO~ONM!ENi Qp ~PO$UR .... o IS.~ ~~IO~!ii:!AiiON OF DATA~S ................................... - . . ~ c. ~ ~'il "1. OON~SIONS AN!> RsOOMMENI:)A'i'fiN$ . . . o o ~ ~- ACNO~~ . . . . . . . . . . . . ~ ~- ~JE:Fe'~E~S . . . . . . . . . . . . . . . . . .. . . . . . . . . . . ' . . . . . . . . . . . II ~ t:W~EJM[)flr 'il ~fEND!}{, 2 T~Le~ OF DATA ~OM ~IAN COI\!WlmH~ . ~ GLO$$AAV OF ~MS .. . . . . . . . . . . . . .. . . . .. . . . . . . liD' TOTAL P.08 BP-00017711