Document ndYLzjgQ2QOrMjDRzRQRmn8X

Evaluation-- 33% 2,^-Dichlorophenol Memorandum to File J . H . Senger D. Wilson H. W. Kilbourne P. J. A m a l i On November 2*1, 1 9 8 1 , the above named persons and the undersigned met to consider whether certain information reasonably supported the conclusion that 93% 2,*l-dichlorophenol. marketed by Monsanto presents a substantial risk of injury to health or the environ ment requiring immediate notification to the EPA. An analysis of 93% 2jiJ-dichlorophenol for chlorinated dibenzofurans (CDF) was recently performed by the Dayton Laboratory. The analytical results indicated that the product contained up to 1 to 2 ppm of total CDF. The- question presented, was whether this level of CDF in this product presents a substantial risk of injury to health or the environment. It was recognized that this level of CDF did not present an acute toxicity risk. After considerable discussion, however, it was concluded that very little was known concerning the chronic toxicity of CDF. Dr. Roush was requested to study this matter, including reviewing the report from the Dayton Laboratory, after which the group would reconvene. The group described aboye (.except J. H. Senger) reconyened on December Hi, 19,81. The limited* information ayailable generally supports th conclusion that the acute toxicity of CDF is approxi mately an order of magnitude less than the acute toxicity of com parable chlorinated dibenzodioxins. Also, it was noted that no 2,3i738-.dibenzofurans were found in the 2,*J-dichlorophencl. Levels of up to 100 ppb 2 ,3 a7 i8r-tetrachlorodioxin. have been believed to be safe levels by some toxicologists for 2,4,5-T. Further, PCBs containing CDF as impurities have been extensively studied. A recent review of the extensive data on PCBs has led to the con clusion that there are no significant human health hazards from low exposure. These considerations indicate that the small con centration of total CDF described above should not be considered a substantial risk. ,It was also noted that the product' has been produced and marketed for 30 to *10 years without any evidence of substantial danger to health or the environment. After considering the information described above, it was consi dered that notification is not required by TSCA 8 (e). Phocion S. &033O