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PO Box No 6 Bessemer Road Welwyn Garden City Hertfordshire AL7 1 HD Telephone Welwyn Garden 23400 (STD Code 07073) STD Code from London Area 96 Telex 264251 Iciplast Welwyn Imperial Chemical Industries Limited Plastics Division R*S 103530 Dr T R Torkelson Corporate Medical Department The Dow Chemical Company Bennett Building 2030 Dow Center Midland Michigan 48640 USA Your ref. Our ref Tel ext Date JS/MJE/DS0-107 3162 29 July 1977 Dear Dr Torkelson Thank you very much for your letter of 6 June which reached my office on 23 July - I think it must have come by seamail. I have checked with David Duffield and find that hie copy arrived on 27 July also by seamail. Hence the delay in replying to you. I am very grateful to you for sending me the NIOSH letter of 31 May plus their tables of 31 March 1977 and their 12 September 1975 table which I agree is hopelessly inappropriate on many counts. The figures I gave in my letter of 9 May included the US as well as Europe and Canada. As I understand the situation, the angiosarcoma cases are stacking up as follows. Table A AS Cases (Alive & Dead) in PVC Monomer & Polymerisation Plants Belgium Canada C sechoslovakia France Germany Italy Japan Norway Sweden UK USA Yugoslavia Alive Dead 1 10 2 8 8* (a) 1 alive (b) NIOSH 08 is not known to CEFIC 2* 1 1 4 1 alive 2T 21* 2 alive 2 62 4 58 * * *** **** Excludes Ge 03 pesticide can filler Excludes It 01 bag extruder Excludes UK 02 which has been totally discounted in UK Excludes US 14 and 15 so called non polymerisation cases which I suspect are discounted in some US circles Registered in England No. 218019 Registered Office - Imperial Chemical House. Millbank, London SW1P 3JF. s t R&S 103531 15 Capacity v No of AS Cases You made the point that the AS cases in Europe are more numerous than in the USA but that capacity is in step with this* I do not know about capacity but if one takes a ,,normal,, year for consumption (ie 1974)* North America looks high in AS cases. PVC Consumption AS Cases to Date North America Western Europe 2.2 m te 3*4 31 26 The Canadian situation does however cause a heavy distortion in the North American situation - if the Canadian cases are deducted however, 1 still think the US incidence looks high in relation to consumption but this may not be the correct yardstick. 16 Clustering of Results The clustering of AS cases in a few places is a remarkable feature of this whole Btory. Shawinigan BFG Louisville UCC S Charleston Kemanord Dynamit Nobel French Plant German Plant BFG Avon Lake Goodyear Niagara 10 AS eases 10 * 4 4 3/4 (4 if one counts the can 4 filling operation) 2 2 2 42 out of a total of 62I There may be further clusters of 2 in Europe but I am uncertain of them and will not make inspired guesses here. -.1 suspect that the Czechoslovakian and Yugoslavian deaths are also clusters of 2. However* if we could explain the clusters of 10 and 4, we could perhaps gain a lot of useful data on VCM as a human carcinogen. Similarly we could analyse why some plants have had only 1 case so far and why many have had 0. Naturally people who have had a "cluster" will be sensitive about others probing into their affairs but I do believe that lack of such data has been a dis-service to the whole industry. In the Du Pont epidemiological survey on acrylonitrile at their Camdeft SC plant, I was struck by their observation that the excess cancers occurred among employees involved in their start-up operation 1950-52. I wonder how many of our VCM clusters were among employees who were involved in start-up or pilot plant type operations. I believe Dr M N Johnson told us once that Louisville was very much a pilot plant in its early daysi 17 Moving Averages of all Known AS Deaths I thank you for your moving and cumulative averages of US deaths in PVC workers from AS of the liv r. Looking at the global picture as we se it, I hav great difficulty in knowing whether things are getting better or worsel I fear "worse" in reality. 3 11 USA 12 Yugoslavia 13 Reconciliation NIOSH Table 1 NIOSH Table 2 I have made some minor corrections to my listings to bring them into line with NIOSH. Is your Case l8 the Charli Arthur of the Rolling Stone Magazine article which gives slightly different data from NIOSH? Is your case 22, th BFG No 10 I give in my list? Which company and factory has Case 23? Can you demolish non-polymerisation cases 14 and 15? No change for some years. No new information. All AS cases by NIOSH 56 cases 7" 63 total myself 62 cases 5 non-polymerisation cases _____ (some dubious) 67* R&S 103532 * Additional to NIOSH France 08 Sweden 03 & 04 Belgium 01 4 14 PVC Producing Countries without AS Cases So far as I know, there have been no AS eases in Austria, Finland, Greece, Holland, Portugal, Spain and Switzerland which produce PVC in Europe. There have been no cases in Australia. I have no data on the USSR or any oth r part of the World. It would of course be necessary to examine the "no case" countries more closely with relation to date of start-up of manufacture and also build-up of seal / numbers exposed at given dates. Looking at the European no case list I believe the start-up dates of PVC production were Austria Spain Holland Finlarid Switzerland Portugal Greece 1953 1953 1950 1972 1945 1962 recent? Some factories eg Switzerland and Holland hav be n in action 1 nger than the latency period. There is a lot of work to be don to correlate capacity build-up, process and plant nature, plant practice in past etc with incidence of AS but regrettably we still lack data here. R&s 103533 6 Table B has some minor differences from the figures I gave you in my letter of 9 May - I think some of the dates of deaths have been altered in the latest listings and 1 may also have made some mistakes* I become a bit dazzled by some of the figures under study and make errors - I hope the present letter is the more accurate. I have not done your 3 year moving average. I have given a copy of this letter to our bio-statistician Dr Paddle for his comments particularly to find out if by calculation of moving averages, weighted averages, etc, etc he can s e any "peaking" of AS cases around 1975 and hopefully the start of a decrease thereafter. When I saw Dr Paddle on 14 June to review what we should be doing in the field of epidemiology etc, one thing to which he thought effort should be devot d was the keeping of a register of AS cases for analysis. I am grateful to you for all the help you have given here and I hope you may be able to encourage Hose Kaminski to continue with her efforts. Assessment of Risks At the present time 1 am busy trying to re-assess risks on VCM in an amateurish sort of way. I was therefore fascinated to read in European Chemical News 22 July page 22 an article on an interview with your Dr Gehring. On the basis of metabolic work. Dr Gehring suggests that 25 ppm VCM exposures would result in no greater occurrence of human angiosarcoma than would be expected to occur spontaneously. The article goes on to attribute to i\im a statement that 1 ppm exposure to VCM would be expected to give 1 case of AS in 100 million subjects ie lower than the spontaneous occurrence* Unfortunately I was unable to attend the Toxicology Conference at Surrey University where Dr Gehring was speaking. Do you hav any papers emerging from Dow on this subject soon? They would be very timely. Any papers or calculations to back up Dr Gehring's statements would be very welcome in Europe. With best wishes Yours sincerely J Division Manager Health & Environment Protection TABLE B 5 r&S 103534 Deaths from AS in PVC Workers in World (based on NIGSH tables 31/3/77 + CEFIC info) Case Number Year of Death Ca 1 Ca 2 US 08 Ca 3 US 05 Cz 2 Fr 01 Ca 4, Ca 5, US 04, US 07, US 10 Ge 01, US 12, US l6 Sw 01, US 11 Ca 6, Ge 02, US 02* Ca 7, It 02, Nor 01, Sw 02, UK 01 Ca 8, US 01, US 03, US 23, YU 01, YU 02** Ca 9, Cz 1, Ge 04, Ge 06, UK 03, US 13 Fr 02, Fr 03, Ge 05, Ge 07, Ge 08, It 03 *** Jap 1, US 06, US 09, US 18 Be 01, Fr 04, Fr 05, Fr 06, Fr 07, Sw 03, US 20 US 22 Ca 10, Fr 08, US 21 1955 6 7 8 9 60 1 2 3 4 5 6 7 8 9 70 1 2 3 4 5 c 0 7 . No of Deaths 1 0 1 0 0 0 1 1 o 1 0 1 1 5 3 2 3 5 6 6 10 8 3 Cumulative Average since 1955 1 0.5 O.67 0.5 0.4 0.33 0.43 0.5 0.55 0.5 0.45 0.5 0.54 0.86 1.0 1.06 1.18 1.39 1.63 1.85 2.24 Cumulative Average since 1968 5 4 3.3 3-25 3.6 4 4.3 5 2.5 5-3 -- 58 *** * ** *** ** ** excludes It 01 (bag extruder) excludes Ge 03 (pesticide can filler) includes Ge 08 in NIQSH list about which CEFIC knows nothing UK 021 US 14 and US 15 non-polymerisation cases (bo called) totally excluded ICX FUSTICS Division BESSQffiR mU WKLYTO GARDES cm LIVER Aaglosarcona Gun - (Rarlav Cat*:- 1 August 1977) Shaat 3 1 2 3 4 5 4 7 e 9 10 11 ia 13 14 15 COtWTRT AHD hue on UTS OF coKPurr ncTonr FIRST VO DATE OF 401 4T nuts op TX1RS OF DATE OP HISTOLOGICAL ESTIMATED cccumtioh cmna RETEREHCE HO 1HITULS BIRTH EXPOSURE DIUH0SI3 Duomsis EXPOSURE EXPOSURE DEATH COHFIRHinOH EXPOSURE CAREQt TO D1A0S0SI3 LEVEL HKHU0BTS 14 other cohmots Oernany (aout'd) 00 19.10.17 09 13.la.34 CVH 19.04.54 1975 (I prasuna 58) aa 31 a5.ia.75 Tss ir s3 ? 00.03.41 (HIOSH ays a.ia.59) ad '74 (HIOSH say l 14.4.74 42 15 (HIOSH lays 17) Still (HIOSH says High liTS w) paaka Autoworkar A claaaer 0 yrc Hart Job 3 jw Control roos 1 yr In HIOSH list of 16.3.77 awaiting dttails, Thai* dataill givan by HIOSH oa 31.3*77. Vhosa oast la this? Why bar* wa not board of It? Still Ally* ______ .______i --------------! ____ _ _ . iH. -W' R&S 103535 R&S 103536 ICI FUSTICS DIVISI0H BESSEMER ROAD VZLVTH GARDEN CITT LITER Ajigiosarcosa Cuts - (Revimr Eats:- 1 *"* 'OT ) Sheet 1 1 2 3 4 5 6 7 a 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE HO NUZ OR INITIALS DATE OR BIRTH coHFunr factory FIRST TO OPOSUBE date or DIAGNOSIS AGE AT DIAGNOSIS TEARS OP OKISURE TO DIAGNOSIS TEARS OF EIFOSURE DATE Or DEATH HISTOLOGICAL CONFIRMATION ESTIMATED .OCCUPATION EIFOSURE LEVEL OTHER CAREER HIGHLIGHTS Osraany OTHER COMMENTS j 01 or 04.06,30 Dynaslt 01.10.56 13.9.68 38 11 11 25.01.6! Tss (NIOSH) Polyworker Datss altered to fit NIOSH 31/3/77 list - 02 03' HA 26.07.31 Dynnlt Cl 16.07.30 Dynaslt? w| 04.0J.30 Haoker j 05 ! HV 01.01.32 Dynaslt 1--------------------------------- ___________________ 06 03.05.36 Hoaobst 07 2J.OJ.76 Vacker . ..... ,1 14.10.57 25.9.70 03.06.52 00.03.73 40 (39?) 43 13 12 14.12.71 Tss (NIOSH) 21 21 10.10.7; Tss (NIOSH (NIOSH) aaja 14) Polyworker mill* pestis Ida aerosol cam with TC 16.04.57 26.11.74 16.12.62 00.00.75 02.04.60 00.12.73 15.04.54 12.11.75 44 17 17 25.11.74 Tas (iiosh (NIOSH - no 117) sonant) Polyworker 8 teap awtoeleansr 43 13 12 10.01.75 Tea Polyworker 39 13 05 16.12.74 Tas (NIOSH eaya (NIOSH (NIOSH) 03) says 03) Polyworker (HIOSH eays assistant factory eheslst) *7 21 21 13.11.75 Tti (NIOSH say* (NIOSH 17) says 12) Autosleaner 12 yrs fsreaan Tech Dew 8 yrs __________ 1_______ ___________________ Datss altered to fit NIOSH 31/3/77 List Reported under 'honpolyatrlsatlon workers In nOSH Ust of 31/3/77. Is this eorrsot? Reported under nonpolyaerleatlon workers In HIOSH list of 31/3/77 ICX PLASTICS MTISIOB Bessemer mad muni oardek cm LITER Angiosarcoma Cases - (Rerlev Ehts:- 1 Augmst 1977) SHEET 2 UX System of dates DAT - HOKTH - YEAR 1 2 3456 78 9 10 11 12 13 14 15 COUSTRT AND REFERSHCE HAKE OR IHITULS date car BIRTH COKPAHT FACTORY FIRST TO EXPOSURE DATE OF DIAGNOSIS AGE AT DUOHOSIS mus or EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATE OP DEATH HXSTOLOOICAL COHFIRKATIOH ESTIMATED EXPOSURE LEVEL OCCCPATIOI other CAREER ED3RL3DHT3 16 OTHER cowcmrs USA 07 RATHOKD SETTLE. FIH3ER? 38-11-31 BPS Lonlvvil 07-09-5- 01-03-74 43 10 16-08-13 Ooodyear Niagara 12-06-51 00-05-68 55 11 27-05-0? Goodyear Niagara 14-10-46 00-03-70 61 IS 17-11-13 Firestoni Pottatov 13-09-45 02-05-69 50 13 EDVARD 01-12-21 TOC S Cbarle - 19-08-44 00-05-74 5a CLEtiDEHIH ston 14 15 16 04-11-27 BTC? 08-05-50 OO-OO-69 41 f 19 [HIOSH lijn 17) 17 11-03-75 YES 17 33 . 20 30 17 10-05-68 ns 33 16-03-70 TES 15 32-05-69 YES 30 37-04-74 YES 18 (HIOSH uyi 17) 4 27-03-6? YES 17 06-05-31 BfO? 23-06-55 11-10-74 <3 19 19 ILIYE? YES 2000 ppa t Raf 1 has wrong figures re first exposure. Louisville Times 29-10-74, 12-3-75, 10-3-76 fief 1 Ref 1 Ref 1 2000 ppm Charleston Dally Mail 21/7/75 Dubious fabrication cjise Dubloua fabrication cast 1951-4 VCM Polymerisstlon From 1954 onwards la Army and other ser vice, 46-50-Army Table 4 In Wagoner Testimony to US Senate. ___ ________ 1 ^fjr m R&S 103537 R&S 103538 ICI FUSTICS DIVISION BESSEHER ROAD UELVTN GARDEN CITT lira Angiosarcoaa Cues - (Review Date:- t August 1977) SHEET 7 OK systea of dates MI - MONTH - TSUI 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 COONTRT AND REFfflEHCE NO HAKE OR INITIALS DATE OP BIRTH COKRANT rACTonr FIRST TO EKPQSQRE DATE OF DIAGNOSIS AGE AT DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS TEARS Or EXPOSURE DATE Or DEATH HISTOLOGICAL CONnRKATIOH ESTIMATED exposure LEVEL OCCUPATION OTHER CAREER fflOOHUOHTS 16 OTHER COMETS USA 01 02 , 03 04 05 06 07 EARL PARKE >7-10-23 B70 Loulsvll e 09-12-41 03-03-73 49 19-06-33 . BIO LouieTil 15.11.55 00-05-70 37 25.05.15 BFQ 15-01-24 BfO 25-01-12 BIO RAT AUSTD 00-00-29 JOKES? BFO Loulsvli: e 28.11.45 19-12-73 Loulsvll e 06-07-51 19-08-67 Loulsvll e 19-06-44 09-04-64 Loulsvll e 17-01-6! 00-02-74 58 43 52 45 24 (NIOSH says 22) 14 28 15 20 12 16 33-03-73 TES 13 27-09-71 TES (NIOSH s ATS 28.09.71 ) 28 19-12-73 YES 15 >7-01-68 TES 18 >9-04-64 TES 12 14-07-75 YES nan with 03-05-22 held at ftally request UCC 3 Charle- OO-OB-44 00-00-68 ston 45 24 18 13-03-68 TES OS Air Force Rolling Stone Art Ref 1 HT Acad of So Sya; Ref 1 Also Blook JAHA 1/7/74 P53 Ref 1 Ref 1 Ref 1 Ref 1 + Louisville Tin 23/7/75 Retired April 1974 Ref 1 08 06-05-20 Goodyear Kimgars 07-10-46 00-08-61 41 15 15 >9-08-61 TES Ref 1 1_________________ ________________ ___________________ - - - .. . ICI FUSTICS DIVISION BESSEMER ROAD warn garden cm urn Angioeaxcosa Cum - (ReTiev Ds.tei- 1 August 197?) Sheet 4 1 2 3 56 7S 9 10 11 12 13 14 15 COUWTRT AMD REFERENCE SO HAKE OH initials DATE OF BIRTH COXPAHX TACTOKT TIRST TO EXPOSURE DATE.Or DIAGNOSIS AGE AT DIAGNOSIS TEARS Or EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATE Or DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LfiVEIf OCCUPATION OTHER CAREER HIGHLIDBrS 16 OTHER CONNORS Is this 22? BFO Loulsrli: 24-01-76 20 ALIVE b 10 Loulsrillt Tims 26-1-76. Ssld to be 10th AS viotia st Belli Ism factory of who* 8 bare 4U so far. _______ U K:f ` -4 j R&S 103539 -- R&S 103540 ICI FUSTICS DIVISIOH BKSSQGR ROAD WELWYN GARDEN CITT LIVEH Anglosaroona Caaea - (Fteriev Datti- 1 Angaat 1977) UK systen of data* hat - month - teu Shaft 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 COUNTRY AND REFERENCE NO noa (st INITIALS DATE OF BIRTH COHRUff rACTOHT FIRST VO EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS TEARS ON EXPOSURE TO DIAGNOSIS TEARS OT DATE Or EXPOSURE DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER moHUGHTS 16 OTHER COMMENTS USA 18 la thla Charlit Arthur? 22-04-S8 It thla EVG? la thla Arm fekt 00-00-94 00-00-75 19 VIRGIL 00-00-15 UCC CHRISTIAN 1 Cbarla- 10-00-43 aton 19-06-75 46 60 , 17 31-06-71 00-00-47 30-01-76 Si CHESTER HINKLE 1910 UCC 5 Chari* 1946 early 1977 aton 67 ss 23 If tbli 18? jkariib ARTHUR 02-10-23 la thla BIG? la this 00-00-49 10th uonlarlll a vlotla? OO-OI-76 00-00-23 22-07-26 BIG IVON UU 00-03-75 52 *7 21 13 02-11-75 Taa 32 32 ALIVE? 2000 ppa 29 22 30-01-76 Ta* 30 22 02-01-77 Taa 27 27 04-12-76 ?*9 06-04-76 21 13 75 . 13 yeara AUTO- HAVT C LEANER 8 yra an TYRE STORE ESTOL PUS ICISER AND CARDOSET _____ Vllllanport Sun Gaaatta 21 Jtmt 1975 Charlaaton felly Mall 21/7/75. 28 yra with UCC at SC Retlrad Btvs Relaaaa 23-2-77 Rolling Stone Kagatlna 15/1/76 J >r;f V' Id PLASTICS DIVISIOX BSSSDffiR ROtAJ) usum QAHDKS CITT UTSt Angioaarcooa Cuu - (Ravlav Data:-1 Augnat 1977 ) 1 i 3 4* 5 6 7 0 9 10 ii 12 13 14 15 COtWTRT WTO RKFEtBC* DO HUS (St INITIALS UTS OP BIRTH COKPIHT FACTOR! FIRST TO acpostns UTS OP DIAGNOSIS AOS AT DIAGNOSIS TEARS OP uposras TO DIAGNOSIS TEARS OP EIFOSURE UTS OP DEATH HISTOLOGICAL COWIRHATIOH ESTIMATED EXPOSURE LEVEL occmnoH OTHER CAREER HIGHLIGHTS 16 OTHER COKHOTS Canada 9 10 19-7-21 16-5-15 . *9*6 1974 53 1953 1976 61 29 73 26 4-9-74 Tat 14 00-04-77 Tat Purnaoa op plpaflttar Uatananea Vorkad orartlat Sooktr Raaotor Claanar Furnaea op alntananoa, packaging Ez-aaokar r~ j ----- .. R&S 103541 . jL R&S 103542 ICI PLASTICS DIVISION BESSEHER ROAD WELWYN GARDEN CITT LIVER Anglosarcoaa Cue* - (Review Date:- 1 August 1977) AU data* use OK systea Sheet *1 PAT - HONTH - TEAR ** All this information should be held confidential until it Is published by Dr Theriault of Laval UniversIty in Quebeo. ** Many of dates altered to fit NIOSH 31/3/77 list. 1 2 3456 78 9 10 11 12 13 14 15 1( COUNTRY AND REFUXHCE NO HAH OR INITIALS DATE OP BIRTH COKPAHT FACTORr FIRST TO EXPOSURE DATE OF DIAGNOSIS AON AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS TEARS Or EXPOSURE DATE OP DEATH HISTOLOGICAL COXTIRKATIOR ESTIMATE) EXPOSURE LEVEL OCCUPATION OTHER CAREER GOOBLIGHTS OTHER COHKDFFS CANADA 1 I 3 4 5 ( 7 a _______ 15-12-13 SHAN NIOAN 1944 1*5 41 (-3-14 1943 1*7 43 26-8-19 5-4-19 1941 1945 19(2 1*7 42 48 7-5-11 15-12-19 9-11-19 1944 19(0 57 1947 1946 1971 1972 51 53 13-5-W 19(1 1973 53 14 14 21 22 24 24 2( 12 in plent 11 2-9-55 Tea 14 21-12-57 Tee 20 23-3-(2 Tea 22 21-1-0 Tes 5 5-7-0 Tea 23 10-4-71 Yes 25 24-12-72 T* 5 12-6-73 Tea Reactor Cleaner Operator polymeris ation Saoker AalntsMinee, Operator, alllvrlght, pipefitter Worked evortiao Saoker Operator, foreaan Worked orertiae Non-saoker Reactor Cleaner Operator, foreaan, Aterooolinj unit Worked orertiae Saeker Reactor Cleaner Voter 000Ling unit Worked orertiae Saoker Reactor Cleaner Kalntsnancq sillwTight Worked orertiae Saoker Reactor Cleaner Machine Shop oper ator and poly unit Worked orertiae Snoker Reactor Cleaner ____________ 1 laintenance aachlne 3ho; In plant * years] Saoker ICI PUSTICS DIYISIOT BESSEMER ROAD HTUmi OARDSH COT LITER Anglos&rooaa Cast* - (Rrrlav Eht:- 1 Afl^ust 1977} 1 2 3 4 5 i 7 8 9 10 11 12 13 14 15 COUNTRY AHD REFERENCE HO Kin OR IHTIALS DATE OP company BIRTH factory FIRST TO EXPOSURE DATE OF DIAGNOSIS AOE AT DIAGNOSIS TEARS OP EXPOSURE 10 DIAONOSIS TEARS OF DATE OF EXPOSURE DEATH HISTOLOGICAL COXFIRKATIOH ESmtATED EXPOSURE LEVEL OCCUPATION OTHER CARETS RDSHLmSTS Tugolrl 01 03 05.04.14 15.tt.31 00.00.53 08.04.73 00.00.50 12.07.73 5? 42 20 20 08.04.73 Ti( 73 18 12.07.73 Tm 16 OTHER COHHmS __________ 1 TFT # 4 m1 . ________ 1 R&S 103543 ICI PLASTICS DIVISION BESSEMER ROAD MELVIN GARDEN CITT R&S 103544 Lim Asglomrcam Casas - (Rrrisv Cat*:- 1 August 1977) 1 3 3 4 5 6 7 8 9 10 11 13 13 14 15 COUNTRY AND REFERENCE NO HANS OR INITIALS date or COMPANY BIRTH FACTORT FIRST VC DAT! OF EXPOSURE DIAGNOSIS AGZ AT DIAGNOSIS YEARS Or exposure TO DIAQNOSIS YEARS OF DATE Or EXPOSURE DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS Cztohoalovaklt 01 03 00.00.3E 00.00.3< 00.00.57 00.00.73 46 00.00.51 00.00.66 40 16 15 16 00.00.7J Y*i 15 00.00M In 16 OTHER COMMENTS _____ 1___ . ICI FUSTICS DmSION BESSEMER ROAD weumf OARDCT CITT URR Angiosarcoma Gases - (Rsyies Datei- 1 August 1977) Should this cast ba reaOTed from the list? NIOSH bar* It tm thslr esppleaentary list raleting to nonpolymerisation vorksrs. JS 1/8/77 1 2 3 4 5 6 7 S 3 10 11 12 13 14 15 comma akd REFERENCE NO KAMI OR INITIALS DATS or BIRTH COMMIT FiCTORI FIRST TO exposure RATI or DIAGNOSIS AOB AT DIAGNOSIS TEARS Of exposure TO DIAQNOSIS TEARS OF EXPOSURE DATE Or DEATH HISTOLOGICAL COKFIRKinOX ESTIMATED EXPOSURE LEVEL OCCTPATIOI OTHER CAREER HmBUQBIS 16 OTHER COMMENTS Italy 01 07 03 15.06.34 00.00.6$ 13.04.71 36 06 03 16.04.71 7T*a PVC Bag Cctruder 13.11.25 rtonttdi- Porto 1357 13.12.72 43 15 06 10.12.72 Taa on ferghera Polyvorker 14.03,20 Solvmy 00.01.53 10.07.75 55 22 21 10.07.75 Taa High iutooleanar 8 yra Autoclave operator 12 jrrs Primary tumour may hart beau pericardium. Not homogeneous with other cases. V - .'.J ' _ ..........-J _______________ L_ ______ J h.;r'A.' R&S 103545 R&S 103546 ICI FUSTICS DIVISION BESSDER ROJU) WELWYN GARDEN CITY LIVER Angiosarcoma Casta - (Rarlev Data:- 1 August 1977) 1 2 34 56 7a 9 10 11 12 13 14 15 COUWTRT AND REFERENCE NO MAKE OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VO EXPOSURE DATE OF DIAGNOSIS AGE AT DIAOHOSI3 YEAR3 Or EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH KISTOLOQICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HZGHUOUHTS 16 OTHER COMMENTS Belgium 01 12.01.1j Solray Jenappe 00.07.58 00.05.76 6jJ IS 17 29.06.76 Yaa High Autocleaner Driller in Hepatic tact* in 14 yrs a foundry October 1974 marc Polyworkar 3 (2 yrs) Faraer (15 yra) normal. Retired Feb 1975 Hospitalised May 1976 Work in glaai lad. & chemical lnduatry 1 l ____ ICI PLASTICS Division BESSEMER ROAD vrunra garde* cin UVER Angiosarcoma Cuts - (Rerlew Data:- 1 August T977) 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 COtWTRT AMD REFERENCE HO MAKE Oft INITIALS DATE OP coxHuir BIRTH FACTOR! FIRST VC EXPOSURE DATE OF DIAOROSIS AOE AT DIAGNOSIS TEARS OF SEFOSORE 10 DIAGNOSIS TEARS OF DATE OF EXPOSURE DEATH HISTOLOOICAL COMFIRKATIOM ESTIMATED EXPOSURE LEVEL OCCDPATIOH OTHER CAREER HIGHLIGHTS Norvay 01 AH T3.H.15 Norsk Hydro 00.03.50 20.12.71 36 22 21 M.01.72 Taa PTC vorker 16 OTHER COMMENTS I '! " * -- ' ---- -- R&S 103547 ._ 1 R&S 103548 ICI PUSTICS DIVISION BESSEMER ROAD UEUm) GARDEN CXTT LIVER Angloaarcons Cases (Review Date 1 August 1977) * Could Japanese PVC Association be asked to oonnent on this table. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 COUNTRT AND REFERENCE NO NIKE on INITIALS DATE OP GIRTH COKPAOT PACTORT FIRST VC EXPOSURE BATE OP DIAGNOSU AGE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH KISTOLOOICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS JAPAN 01 TOHOJI HORI MITSUI TOATSU 01-00-22 HAGOYA 1951? ' / NIOSH |00-04-53J 21-08-75 / NIOSH \ f 21.08.74 \/ 52 stnzuo SATO SHIGEO TANAIA SUB CON. NAGOYA TRACTOR TO MITStr TOATSU MITSUI TOATSU HAGOYA 1953 Nor *60 43 XAZUYOSHI 0N0 MITSUI TOATSU NAGOYA Deo *6? 17 13 yra auto- Japan Tinea 25-10-75 often slave 0leans r 22 22 24-10-75 YES 3000 ppa 1964-asslgt id / NIOSH .] ( Bo eoBaeny and no pro - to differs it teotive (oric alnee h id neasures LU health. until 1974 Reactor cleaner 1964-1974 Pre-canearoas disorder sf liver. Japan Tines 25.10.75 16 14-01-69 Deo *67 Japan Tines 27-10-75 (sons figures uncertain - bad print) Japan Tines 27-10-75 * 1........... ................. ICI PLASTICS DIVISIOH BESSEMER ROAD WEUnm GARDEN CITT uvra Anglosarcoaa Cum - {Review Eate:-' 1 August 1977) 1 2 3456 7a 9 10 11 12 13 14 15 CO0HTRT ADD NAME OR Din or COKPAKI PACTORT FIRST VO Din or AOI AT TEARS OF TEARS OF DATE or HISTOUOICAL ESTIMATED occupation OTHER HETBUfflCE HO INITIALS BIRTH EXPOSURE DIAGNOSIS DIAGNOSIS EXPOSURE EXPOSURE DEATH COKTIRMlTIOH EXPOSURE CAREER TO DIAQNQSIS LEVEL kxghudhts 16 OTHER coHKnrrs UK 01 ICIWJ 20.04.01 Hillhow 00.00.44 00.12.72 71 28 22 00.12.72 500 pp- 1944-7 VCH 1947-8 Drier 1940-61 Autoclave operator 1961-66 Drier 03 BJU 02.06.37 BP Berry 00.02.66 00.12.74 37 09 3.5 24.12.74 r* Autool*re cleaner Exposure Halted to 2/66 - 9'69 * NIOSH are etill quoting Case 02 fron loco vlicb bee. been discounted in the UK. IOCO spread cany polyaere Including PTC onto fabric!. * ----------- ----- v^ R&S 103549 . R&S 103550 ICI PLASTICS DIVISION BESSEHEfl ROAD WELWYN GARDEN CITY LITER Anglosarccm Cuts - (Rertew Ceito: -- 1 August 1977) 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 COUNTRY A)0) REFERENCE NO HAKE (St INITIALS DATE OP BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAONOSIS YEARS OF EXPOSURE TO DIAONOSIS YEARS OF EXPOSURE DATE OF HISTOLOGICAL DEATH COKPIRKAnOH ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS Sweden 01 02 NO 23.06.27 Kaaanord BL 27.11.11 Keaanord 14.08.51 20.10.70 00.01.45 00.08*72 *3 61 19 27 03 HE 10.06,10 Kemnord 00.05.47 1B.03.76 65 29 .04 Keaanord 19*5 1977 62 18 20,10.70 27 16.08.72 Tm Yes 21 19.03.76 Yes 31 Polyworker VCM production High Polyworker High 10 years polyaerisat; on and 20 years foreBan but Mr Blonquist reraabers bin as polymerisation worker and personally pulling hia unconscious froa the PVC works In first 10 years of eaploynent had been hearlly exposed. ______ 1___________ -- . r&S 103552 i | jci m.Mjos wi,;.r jv bisismii-ti r.o:.>) we[;./vtj G'.ura cirr UVLl: AiislonarcoK'i Casus - (Review iv.ta:- 1 Ai'yel 1?W/ | 11 2 3 6 7 ri 5 10 tl . .. 13 14 15 coumto aro itcma/;c;: ro HA tCC OR INITIALS bat:: of Dlll'i'C Finer V'.; KCSOaURO W.TE OF iuaoiiosis (CB AT DUU1I05IS YEAR:! OF WKirilKfi TO DIAGCOKIS YEA111! OF KXF06Uii" FATE OF Ilf-Vi II MOTCI/'OfCAL A`f;vjf,ATK k'.Oa'ltE LrM!, pc'.-i.tatio;; O'iF! 1! luOUUOllTR 16 011,771 C.Mr fha/as 01 02 03 01 0.1 06 15.01.21 00,01.46 18,0?.67 43 03.06.11 06.07.55 15.01.75 63 06,01.SO 00.00.16 15.01.73 55 S7.ol.37 15.10.43 16.01,76 4? 25.01.30 lu.0i.G5 13.05.75 30 14.4.31 01.03,58 ia.oo.7C 42 ' Si 19 19.OS.67 Te? 16 is 2-1.01.75 Tus 2? ' ?9 S9.C6.75 Yen 26 ft/ 01.01,76 Tea 11 11 13.05.76 Y&.n 10 13 11.09.76 Vo 3 (1110311 (1II03H nys 17) 12/13,76 MJ.Sh IH:;h ilifjh J'lfih lllfili iriKb 'olyvorhcr 19 years Pf, RarJor at A1 Arch, F . 1. FroF, 1 30 n 3 - no-s 75 p. 171-1/7 I'olyworl'.r > 10 years *. R, Poena ton oi ` "Roiirellu pro:ir, tictllealo" 5 nw. 77 - p. 735 Filyworkor 10 years YCH tro- luC. Rely <jt A1 itucticn 16 Arch, Mnl, Frc>r, years Coo- 1 37 n 6 Join 76 j ouniira ? 0, 551 - 565 years hredue tion worker U years AutocZeaner 18 years Poly-worker 11 years Polyworker 10 years , Ref P Ccni-loro ut A1 "Reir.-.jno Res,hepLtauc 10 Erptenl'n1 76 Previcmr.ly hail tors crgltBaroora" icx w-iiius nav-ioa DKSiiuu.n lioAU vixvtH QAiiDKif city UVKR Anglosanxca Cases - (itorloif fetor- 1 Aug.-at 137?) i, - f-t U i. 2 3c 70 9 10 11 12 13 14 15 couin-siv Aim KM OH hath op PIItST VC DATE OP ACE AT YEAH3 0? TEAH3 OP BATE OF IITETOIOOICAI. ESTI11ATE0 OCCUI'ATIOi.' HEKHiEACE TO imim HIM EXTO3W1B DIAOTOSIS BIAOUOSI3 i.-:rosoiiR CdUSUKS HEATH COHFIHfUTOM l'XTOKUKE TO DIAGNOSIS LEVEL OTHEl! C*ilV~2 1!j OTttFdR CCW-irS K Cl 1 07 00.00.2? 01.07.50 After *9 26 death 02.07.7f Yea High Plant forensn Died c? anptieftorjlft Spall ii/or loaion found :Jtue autopsy 03 01,04,34 23.05.57 03.12.75 42 19 19 30.01.77 Yaa High Fnufcnr then polyuorher . 1 i \ 1 es se<n S9U R&S 103554 COUNTRY BELGIUM CANADA CANADA CANADA CANADA CANADA CANADA CANADA CANADA CANADA CANADA CZECH. CZECH. FED.REP.GER. FED.REP.GER. FED.REP.GER. FED.REP.GER. FED.REP.GER. FED.REP.GER. FED.REP.GER. FED.REP.GER. FED.REP.GER. FED.REP.GER. FRANCE FRANCE FRANCE FRANCE FRANCE FRANCE FRANCE FRANCE FRANCE FRANCE FRANCE GREAT BRIT. GREAT BRIT. ITALY ITALY JAPAN JAPAN NORWAY SWEDEN** SWEDEN SWEDEN U.S.A. U.5.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A.^ U.S.A. U.S.A. U.S.A. YUGOSLAVIA FEBRUARY,1979 TABLE 1 REPORTED CASES OF ANGIOSARCOMA OF THE LIVER AACNG VINYL CHLORIDE POLYMERIZATION WORKERS 1ST VC DX AGE YEARS TOT. CASE NO. 01* 01* 02* 03* 09* 03* 06* 07* OS* 09* 10* 01* 02* 01* 02* 09 05* 07* 08* 09* 10* 11* 12* 01* 02 03* 09* 03* 06* 07 OS* 09* 10* 11* 01* 03* 02* 03* 01* 02* 01* 01* 03* 09* 01* 02* 03* 09* 03* 06* 07* OS* 09* 10* BIRTH DATE 01-12-13 12-13-13 03-06-19 OS-26-19 09-03-19 03-07-11 12-13-19 11-09-19 05-13-20 07-19-21 03-16-15 00-00-2S 00-00-26 06-09-30 07-26-31 09-09-30 01-01-32 09-29-26 10-19-17 12-13-39 07-23-29 12-29-36 06-19-3S 09-13-29 06-03-11 00-00-19 01-27-27 01-29-38 09-19-39 00-00-27 09-01-39 10-0S-19 05-26-19 02-15-12 09-20-01 06-02-37 11-13-29 03-19-20 08-01-22 08*02-39 12-23-13 06-23-27 06-10-10 11-16-19 10-17-23 08-19-33 05-25-15 01-13-29 01-25-12 11-23-28 05-03-22 05-06-20 11-08-31 08-16-13 OR PVC EXP. 07-00-58 00-00-99 00-00-93 00-00-91 00-00-95 00-00-99 00-00-97 00-00-96 00-00-61 00-00-96 00-00-53 00-00-37 00-00-51 10-01-36 10-19-37 09-16-37 12-16-62 09-13-59 09-19-39 12-02-39 10-10-33 01-02-61 09-01-61 01-00-96 07-06-39 00-00-96 10-19-99 00-00-63 00-00-58 07-01-50 03-23-37 01-10-98 12-29-36 01-00-91 04-09-99 02-00-66 00-00-57 00-00-53 09-00-53 11-00-58 03-00-50 08-19-51 05-00-97 00-00-96 12-09-98 11-15-55 11-28-95 07-06-52 06-19-99 01-17-62 08-27-99 10-07-96 05-28-95 06-12-51 ANGIO- AT SARCOMA DX 05-00-76 63 00-00-35 *1 00-00-37 *3 00-00-62 92 00-00-67 98 00-00-68 37 00-00-71 31 00-00-72 33 00-00-73 33 00-00-79 53 00-00-76 61 00-00-73 96 00-00-66 . 90 09-19-68 38 09-23-70 39 11-26-79 99 00-00-73 93 11-12-73 99 00-00-75 58 06-16-76 92 06-28-77 97 00-00-77 91 00-00-77 39 02-18-67 93 Ql-Ot`7) 63 01-00-73 33 01-09-76 99 09-00-76 38 09-00-76 92 07-00-76 99 12-03-76 92 09-26-76 .62 01-10-78 58 08-12-78 66 12-00-72 71 12-00-79 37 12-13-72 93 07-10-75 55 08-21-79 32 08-10-76 37 12-20-71 36 08-00-79 93 03-19-76 63 03-12-77 62. 03-03-73 99 05-00-70 37 12-19-73 58 08-19-67 93 09-09-69 52 02-00-79 96 00-00-68 93 08-00-61 91 03-04-79 93 05-00-68 33 1ST EXP. YRS. TO DX EXP. 18 17 11 11 14 14 21 20 22 22 24 05 24 23 26 25 12 05 28 26 23 14 16 16 13 13 12 12 13 12 17 17 13 12 21 12 22 21 17 13 22 22 (6 10 16 06 21 19 15 12 29 29 26 26 11 10 JS 17 26 23 19 19 28 28 21 21 37 . 31 28 22 09 . 04 13 06 22 . . 21 22 22 IS 13 22 21 19 IS 29 21 31 31 24' 21 14 13 28 28 15 20 20 12 12 24 17 13 13 29 24 17 17 11* 05-27-09 10-19-96 03-00-70 61 23 12* 11-17-18 09-13-99 05-02-69 30 20 13* 12-01-21 12-11-92 05-00-79 52 32 16* 11-09-27 05-08-50 00-00-69 91 19 17* 05-06-51 06-23-55 10-11-79 93 19 23 19 26 04 19 IS* 09-22-28 09-15-59 00-00-75 96 21 19* 00-00-13 00-00-93 06-19-75 60 32 20* 08-31-17 00-00-55 01-30-76 38 21 21* 09-02-09 12-00-96 00-00-77 67 30 22* 10-02-23 07-11-97 01-00-76 32 29 23* 00-00-23 09-08-58 09-06-73 50 13 29* 05-07-17 00-00-39 05-27-77 60 38 25 08-07-10 02-00-97 03-10-77 67 30 26* 07-07-23 10-03-97 00-00-77 52 21 27* 05-11-16 07-01-91 11-30-78 62 37 01* 09-05-19 00-00-53 09-01-73 39 20 11 22 18 21 28 14 26 20 IS 27 20 DATE OF DEATH 06-29-76 09-02-53 12-21-37 03-22-62 01-21-68 07-05--68 04-10-71 12-24-72 06*12-73 09-04-74 04-00-77 00-00-74 00-00-66 01-23-69 12-14-7 1 11-23-74 01-09-75 11-13-73 12-23-73 03-24-78 06-28-77 03-07-77 10-07-77 02-19-67 01-24-73 06-29-73 01-04-76 03-13-76 09-12-76 07-02-76 01-30-77 12-16-77 01-10-78 11-13-78 12-03-72 12-24-74 12-00-72 07-10-73 10-24*73 08-10-76 01-04-72 10-20-70 03*19-76 05-12-77 03-03-73 09-28-71 12-19-73 01-07-68 04-09-64 07-24-73 03-23-68 08-29-61 03-00-73 05-10-68 03-16-70 05-02-69 07-04-74 03-27-69 ALIVE 11-02-73 04-06-76 01-30-77 01-02-77 12-04-76 09-06-73 03-27-77 03-10-77 02-11-73 11-25-78 04-08-73 TOTAL REPORTED CASES <70 --DIAGNOSIS WAS MICROSCOPICALLY CONFIRMED *00"--IMMCATES UNCNCWN DATA THIS CASE WAS LATER DIAGNOSED AS HAVING CHOLANGIOSARCOMA. ______ THIS CASE WAS CONFIRMED 9 YEARS AFTER DEATH THtOUGH A REEVALUATION OF THE MIOtOSGOPIC SLIDE DIAGNOSIS AT AUTOPSY WAS PRIMARY LIVER CANCER. 1 AOWU6I.1V70 \ ' *3 . // BEIXIMfEU CASE a Ilf T AIILL l AMGlQSAt.CLMA Uf T ML ----------------- ~----- ---- tUIM-mua~l^ IMIWHU.iUAI.UM>- ISVILMC C.AM_O_NG . --... --. ................ -- "A w(.riiNl >i> 1**1 YC D* Aoe Yh AH S 1CT< JAIE CA6 NO, UlklAl- TM -lik- PWC.-- AM410KUAtt, hXl>. SAhCUHA AX-- -- L3J-LXM . ---a*. JX TO OX LAF. death ^ . 9 (/) J * Ml l.taUjM cana.:a CANADA oi* , 0l-t2*t3 07-00-56 05-00-76 02 16 0I*H 02* 12*lo~la -ji- -- - 00*00-55-----4 1_-- LI 02*040-14 00-00-42 06-00-*5 7 42 14 17 ,,U_ Oo'TM#---022>**57i6* 14 12-^1-S7 . ,, ^ _ O 1 CAUAilA 04* y-*o-1* 00-00-41 00-20--o2 42 21 20 03-J2-62 W CANADA - 04* . 00-00-43.-_-2A-02*t2_ 4d---42------- ^3.-- ---- tL CANADA 05* 05-0 t- 1 I 00-00-44 00-00-68 57 24 05 7-90-63 YU *"l C AhAuA 06* 12-10-10 lo-oo-%7 00-00-71 51 24 23 0**10*71 CANAOA CANADA - 07* o** * ; CANAOA ON* 11-00-15 00-00--iu- JJ-00./2 ,.^*2._- Zii --- -28_ __ 05--12--20 00-00-61 00-00-72 53 12 05 Ju--12--73 07-IV-2I OO--00--40 . 00*02-74 52 26 26 OV-04-74 CANAU.V 10* 06*lo~l5 00-00*53. 00-20-76__ 61 ______1A_ J4*oO-T7 C/lCM* 01 * 00--00--20 00-00-57 00--26--72 44 10 16 J--09-- 76 i ; c/*.ch. 02* 01* 00-00-26 Oi^oO--ot oi-o-2a_ - -l_6^aL-fS/)_ 0602---102U--*h2H6 410A 15 l9 13 00*00-64 17. _ill--26*69. . ' Ff.O,HEH*GLR* 02* 07-26-21 10-14-57 09-i2-70 29 13 12 12-- 1 A-- 7 1 Ft :i .r rr . 0* 99-0%-30 0.- lb-67 1 1-26-74 44 17 IT 11-23-7% f l.lU-'aL (Ut.H* 05* F i iJ * f< i* * UtT/ 0/* r t ii *w i f* *gl* O0* j ' Fuu*Ki.P*GLJ - 05* Ul*0t~32 00-20-2^ 19*19-1/ 12*1^*34 lZ-lb-6_ 04- 1 j" j** 04-1 9-54 12-J2t3-- 00-06-75-_.41 1 l-l4-7a 40 00-20-78 56 .02- 16--7a. 42^ --213j----------L122-_ 22 21 LZ__ 11-13-75 12*25-75 .-33^2%-ZU____ F Co*Hf.l'GfcH . 10* 0 7-2 o-29 10-10-55 02--r*o--77 47 22 22 06*20-77 ! Ft.n.i->.cr.n. Fgj*t:i*6M* . 1121** 17-25-20 04-14-22. ol--07--61 00-20-77 41 Q4-JL-6l_. .00-02-00__ 16 -- ao. 10 03-07-77 _ Ui=J)l~T2___ FHANLt r HANCf* 1 FkANCL 01* 02 03* 34-l-*-24 06*02--11 00*02*15 01-00-46 02-10-07 07-06-50 01-00-75 . . 00-20-44*- -- O1-00T-75 43 63 ,,_3i_ 21 3150 19 02-19-47 12 01-24-75 2N 06-^9-7* MAMCt 04# 21-27-27 1 6-|9*40 01-04-76 49 26 26 01-04-76 MANCL * f ra*iC 05* 01-7V-JA 00--00--65 24-00-76 36 06* . 04-14-24 . ,QO-Oa-2Q___fl9-0O*7o__ A> 111tt 10 03-13-76 _17 09-I2-7A ; FMANCZ FRANCE OF OH* 00-06--2 7 07-01-50 07-00-76 49 26 04-01-2* 05-22-5/ 12-02*76 42 10 23 - 07-02-76 10 01--30--77 1 FllANCe. FMANCl ' C-Wt'Af UU1T. ' ' GALAf CHI I. 05* . 1 0* 01 * JJ# io-oti-i* 05-2-19 06-02-27 . 01* 10-4 0__04-2o-7u.ai,. l-i4-S6 01-16-78 56 'J4--04--4 4 12-02-72 7\ -33_____ 21 20 -23-. 21 22 _ 02-00*66^. __-XI-- ~JU^_ .04 Ii-1L.-7T 01--10--70 l1-2'--703--772. I T*LY ; --1TAUY 02* 72* 11-12-25 00-1 *-20 02-00*5/ 00-00-52 li-lJ/I 07*12-76 43 55 15 22 06 12-30-72 21 07-10-73 ^^Hapan *AY 01* 02* 00-01-22 00-02-26 04-2(9-52 _ 00-21-74 1 1--10-50 OH-12-76 3272_-2IZO__ 31* 12-22-15 02*02--50 12-20-71 56 22 22 10-3%-7S 13 Od-IO--74 21 01-04-72 |4 Swt lit' N 01* 02** 0** llt-3.W7 Ov* t 0-- 1 0 U-lo-14 Jd*14-SJ__ 00-- 00--4 7 20-00-/4.. 02-19-76 -j__ 11*-----09 2*0 00-20-46 05-12-77 6Z 31 'ia,, 21 31 10-20-70 03--iv--76 93-12-77 , U A* U.S.A* U.SA* * U* > A* U J-A . U * !* A * U,'\.A. U A ^ -- Jl* 10-1/-2J 0*** 06*1 S-32 02* 05-25-15 J* * ai-i*-3% OJ# Ol-.'li-lii J4t 11-24-2H J7* U--J3-ii2 0 4# 05*06-20 09* 11--j..- ii 10* . . . 06-16-12- 12-0'J-4a~ -.oj-oj- __-49 11-15-55 OS-OU-73 37 1 1-74*45 12-19-73 56 07-06-52 . 06--19-o7... 44 06-17*44 W4*29--04 22 01-17-62 02*00-74 44 U3-2/-44. OJ-JO-ti6_. 45 10-J7-46 04-00-61 4| 0*- *S2--4 5 02*21-- 7 4 *47. >J. ^ .21. 14 13 2S 20 -.15------- .13 20 20 12 ' 12 ,2A___ .17 15 IS 29 21 4T _03-113^73. 04--2H--7l 12-10-73 ..01-07-66. ________ 04--os--04 07*24-75 00*3-*2S3--*4fc0l .. . . *. 03-00*75 .... . ___ _______________ ., _,, U.S*A* U^A * U*j*A U*^f A* U '> # A . Ut'jtA* Ut'ttAi U *'** A * m 2 1* 12* 12* 1 a* 06--2 7-J** I l-l 7-1 ti 12--Jl--21 1 | --.*4--? 7 - | 0* | 1-46 04-12-49 12-11-42 26--4JH-- 50 03-00- 70 05*22*6# 05-20-74 41 50 SC 23 20 32 - -62-20--4N--r--4 L- - - V<L-------- 23 19 26 03-16-70 09-02-60 07-O4-74 ---33-37-60........ ............. ....................... ................. 1 7* 1 Is* >n Oa-j%-JI CO-2 j.i- u-i / OOuS--. H1 25---5A*j 00-02-42 CO-02--ji. 12*11-/4 02*22--/S 0-is-75 01 *20-- 7 4 2 19 u 21 20 32 -a5t6- 2in1 1 0* ALIVl. 11 I 1-02-75 22 04--Uo--7o 16 J1-3J-77 Uj A (J * 'j A * UtS>A* A 2* ,* J* i* A* 10-0C-2J 07-1 1-4 7 01-02-70 j* 29 00-00-22 Ob-07-17 ii1*-- (14-26-/2 2 3 Ou-JO-39 .. OC-27-77 . 60 15 36 26 l2-04-7b 14 .26 0054"-"0*10Z---7737.-. ........ .....--m.~ .,...__ .. ___ Ot .it A Ui(i*At YlJCw^AVU 2 5* 20* Jl* JO-O/-10 ABA IIino 04-05-14 02--06-4 7 02*10*77 u7 30 20 03-10-77 DETAILS 00-22--52 . - 04--il*72 , 50.-- CO--- ____ ^2U- . , 04-04*70. . ..... - - --- ---------------------- - ----------- A---- ---- - - ---------------- ---- _____ __ TnlAL H FI'STffl 6A5S * 6* *J * - - ----------j---- . ----------------------- - -- ------------------- --iiIAOnilElS A.i Ml EMCSI.MMCAL4.Y CCNFIHMtO "110"--I'JLllCAT! S UNKHH.X ^^^E mm LA.,1 **_. (..(IMF til AbMILI Aul n* UATA - . U * Yl AH I, A IlH lilAtH 1MHUU6H MY LIVI-.M LANCHI. ,, _ A (.LE VALUATION .. lE THL ,. a ICKCSCL91c 3LIDLS. __ - --^ NJUSH ... xtreosT, 1*70 tad lfi--------------------------------- ---------------------- REPORTED CASES OFDNCIUSARCaHADF"THmVEOTOW -------------NnH-PDLVHERTZATION"HnBKEIS'EXPDSED TU'VC-- 1ST"VC------"mt------------ "AGE " TEARS----- "TDT~DATE---------- COUNTRY' CASE NO, HIRTH " DATE --dr^fttc EXP. ENGTU- AT ~3ARCUHX---- OX rsrw. "YRS ~~OF------------TU DX Txrr DEATH feo.reptbeft. 1 03* o fib-io 06-09D2 03-00-73 S3 21 14 " 10-10-73 TOTED FEO.WEP.GER, Ob* GREAT bR IT , 02* ITALY 01 SNEUtN " 1)2* U # 31 * s IS* 05-09-16 t-02^6o TFff-00-74 ' 3S 10 03 UV-Ob-lO (T0-O0-9S~TF2VtfffV7ir* "55 is---------- 11 06-15-30 oo-oo-bb 00-19-71 3b 06 03 i i-2t-h"~ 00-00-95 . os-oro-7r~ 61 27 OO-00-2S 00-0TTVO0 07-00-72 - 47- 00 23 00 12-16-74 TOTED "12-00-70"' TOTE 1 ' " ": 09-16-71 --NOTE-2*7------------------------ 08-16-72 notedh D 2^15-73" --TOTED----- YUCOStlVTS YUGOSLAVIA 02* tr-r5=rt "00-00-50 ' " 07-12-73 " 4Z 1 03* )2-21-31 Ob-Ott-54 Ol-11-76 05 13 IS "07-12-7A --NOTE 3--------------------------------22 81-11-76 NOTED Nnn r~putijNt; pveoif h ik ran e-os i oniri c d a sets-;------------------------------------------------- NnTr"2"^PfinDUcriOKrTiF'FVC^ACKy;---------------------------------------------------------------------------------------------------- NOTE ITPHQDOC mun~of vinvit"CHCTJifiDF; note s"'s_AccouNTANr at plant naking pvctfabrut;----------------------------------- Nf>TE~b~~^~rDAOING~PESTlClE>E~CA~ffS~gnH~TC PROPFULTFiTi--------------------------------- NOTE 7"V"ANGI0SARC0MA "lNvOLVlNG_TIVEFrrTUNG"XMOTETainROIIIH.-------:-------- ALTHOUGH MFFlCULT~T0~DETERHlTlE7~PRrHAHY'SITE SEEKS TU HE-- PtHicAwoitjM;---------------- ------------------------------------------------------------------------------------------------------------ NOTE 9 -"ASSISTANT FACTORY chehist; :------------------------------------------------------- NOTE 10-"fhiS""HAN -as HEaVIL"E*[POSEO"TO"VEH in an ouj inouoh PLANT --DIAGNOSIS *AS ^ICKOSCOPICAILY COnFIRmED oo" --INDICATES'UNKNOWN data FED.REP.CfeP, Ffb.bfp.rpp. p /.___ 06* 09* _U-LStf5_--LL=J.2-_7i___ 10-19-17 00-19-50 00-00-75 56 lP.13.3u 12-02-50 06-16-76 02 22 17 M fed.pep.gfr. _FFn.fiEP.GER- FED.REP.CER.' Egft.CgP.figR^ FED.PEP.CER. Ffb.pfprfp. feo.rer.cer. France France France France FranCF France France France France France France France France ... _ 10* 11* 07-25-29 12-29-36 10-10-55 01-02-61 12* 06-10-38 OO-Ol-fcl 13* 06-03-29 . 10-19-53 15* 06-06-37 11-01-61 16* 0.0*00^33 0 i 1 17* Do-00-37 11-01-61 ' 01 * 00-15-20 01--00--06 02* 06-03-11 07-06-59 u3 00* 05* 01-27-27 01.29.3ft 10-19-09 1)0 -- 00--65 06* 07* 00-10-30 00-00-58 o'o-nn-27 . 01-01.50 06* 09* 00-01-30 05-23-57 io-OA-io __.D5 1 0. a g 10* 05-26-19 12-20-56 11* _ 02-15-12 oi-oo-oi 12* 08-16-10 02-09-09 13 01-19-3! 09-23-03 06-28-77 00-00-77 00-00-77 10-09-78 08-10-76 0B-07-7B 0B-1O-7J1 02-18-67 01-08-75 01-00-76 00-00-76 09-00-76 07-00-76 12-03-76 ftjm 01-10-78 08-12-78 05-00-79 06-26-79 07 fll T* 09. 01 40 01 03 63 55 09 3fl 02 09 02 62 58 .66 65 00 22 16 16 25 16 23 16 21 15 29 26 11 18 26 19 28 21 37 30 16 GREAT BRIT, GREAT bctt., 01* 00-20-01 00-00-00 12-00-72 71 26 03* _ _ 02-00-66 12-00-70 37 09 Great BrIt, 00* 06-23-20 00-26-50 06-00-79 59 25 Great BrTt, ... ...05___ 03-30-1 a oi.oa.5i 10-00-79 65 28 great brit. 06 00-00-31 00-00-62 01-09-80 09 16 Italy____ __ _02*_ _ il.J 3-29 00-00-57 12-13-72 43 15 Italy 03* 03-10-20 00-00-53 07-10-75 55 22 JadAn 01 OR.21 -711 52 22 Japan 02* ________ NnR.AV___________ Q1 ___ SnfOEn** 01* SkEDEAi___ Sweden 00* 01* U.S.*. -U.S.A.___ OiSt^i 02* 03* Ofl* UT-AT U.S.A, JL&jl. 06* -lXs^A- U.S.A. -DZt- 08* -H.S.A. -DS*. U.S.A, 10* -U-S.A. _XL*_ u.s.*. u,<.* , U.S.A. 12* -ii_ 16* _Ur8.A. 17. 08-02-39 12*23-15. 06-23-27 11-16-10 10-17-23 08-19-33 05-25-15 01-15-20 _0X2S*.12_ 11-23-28 -&5mii3*22- 05-06-20 08-16-13 J15j23 11-17-18 -X2j..Q 1t2.1. 11-00-27 11-00-58 06-10-76 . 37 -o3.ftQ.5p_ 12-20-71 56 08-lfl-5l 08-00-70 03 18 22 19 00-00-06 12-09-08 05-12-77 03-03-73 11-15-55 11-28-05 07-06-52 05-00-70 ;i2r-19al3 09-19-67 -OOalSailO- _0JI,,-096S01-17-62 02-00-7fl JHa2JsJiU- QA-JLO*iig- 10-07-46 08-00-61 J!5_- 22-OS___ 03-i l-7fl 06-12-5! ,10-1 flap6- 09-13-09 05-00-66 03-00-76 05< >02-69 _l2rJ_l-02____OS; OQ-70 05-08-50 00-00-69 1 o-l1-To 62 31 09 20 37 1 58 88 03 15 _S2_ _2JL 06 12 -05. -20- 01 15 03 29 55 17 -&J-- -2350 20 32. 3? 01 19 03 _ 19 U.S.A. U.S.A, 18* 19* 00-22-28 09-15-50 00-00-75 06 21 00-00-15 00--00--03 06-19-75 60 35 ... U.S.A. u.s.A 20* 21 * 08-31-17 n9_0#-0-9 00-00-55 01-30-76 58 j 2-on_i|h .00-00-77 . 67 21 3 0 ... U 5A a U.s.A. 22* 23* 10-02-23 07-11-07 01-00-76 52 29 -no-no.23 04-116*73 50 15 U.S.A.+ II . A 2o* 26* C5-07-17 00-00*39 05-27-77 60 07-07-73 __ LO-U1-07_____00-00*77__ 52 36 7ft U.S.A. 11, a. A 27* 05-11-16 07-01-0] 11-30-78 62 2ft * ___ 0U-LA -1.7____ nft-OP-un_____ LAj.11.3_70__ 37 tn U.S.A. YtlCf>Sl_AuT A YUGOSLAVIA ;7 29* 00* 10-12-07 06-11-30 05-OU-O2 03-00-80 nfl.00-53____ DU-06.73 j2-15-S8 09-03-78 72 59... 48 36 ?o 20 "i * -Uliuv73~ 17____ 11-1.-71 21 12-25-75 15 03-Pa-TP 22 06-28-77 10. 03-07-77 06 10-07-77 20 10-23-75 11 08-26-76 20 08-07-78 _ 11 08-28-78 19 02-19-67 12 01-20-75 29 06-29-75 26 01-00-76 10 05-13-76 _ 17 09-12*76 23 07-02-76 19 01-30-77 2B 12-16-77 ... 21 01-10-78 31 . 11-13-78 27 .06-24-79 13 ..... `08-22-79 22 12-03-72 00...... ..12-20-70 16 10-12-79 21 11-19-79 12 01-09-80 06 .12-00*72-- 21 07-10-75 22 10-2O-75 13 08-10-76 _____ 2J------- 01 -- 0 0 --7 2 18 10-20-70' 3J e </> . 0 G> tn 31 05-12-77 21 03-03-73 13 09-28-71 ___ 2fi__ __ 12-19-.7-3____________________ 15 01-07-68 -20- 12 -mijQg-ha 07-2U-75 -XZ- JX3.t23n.6A_ 15 -2JL 17 08-29-61 03.00.75 05-10-68 -23- -oAs-Utza- 19 05-02-69 -2600 -OJaDflaXfl03-27-69 19 nA-On-nft 1 1 11-02-75 22 OO.Ou.TA 18 01-30-77 01-09-7* 28 12-00-76 10 -00--06--73 26 05-27-77 1 ft (17-1 | -75 27 11-25-78 \1-ftl.Tft 16 03-01-60 aH.Aft.7t 18 09-03-78 TQ1AI REPORTED CASES = 81 --OTAGiinsJS -AS `'TCOOsenPICALUY cPN'FIRMfD JUio3.n*J:.DI1;*JEs _____________________________________________________ _________________________________________________ This CAFE -AS UATPA OTAGnosfd AS HAVJMU CMOLAr,ClOSANC'MA, .t*JUI.S-CA6--fcAS--0!jf IK.-EO. O YE.AKS AFTE DEATH ThROuGm A f:EEVALLiATIC6l. OF--lME-HlCKnscQPIC. SL-1DFS., DIAGNOSIS at AUTOPSY -AS PRIHAfiY LlvEk CANCER* -