Document n9vvkY29Md70akE99D7OrZnjz

U)KIS lRI <>f I SI IM; KM! l S UK Ml-'l MAM HI.I I <*JAC II n/ithiiK .Si't n'ftJ/i - I H'JIMOK) KAS \SA(.II K I i K.AVDI.N > IA S SI X I ON OKI? ISUISUI HI-.NKY MOSS JA< OH KKI O / i'Viil ( ,nni\rlnf otoi) iu;kns ices >&e ANNALS OF THL NEW YORK ACADEMY OK SCIENCES l) 11 , rrr--.T, :* '' '* ., ' . .. . ................... , ' Volume 246 ` January 31, 1975 Volume 266 ci/PV ? TOXICITY OK VINYL CIILOKIDL-KOLYVINYL CHLORIDE* Editors and Conference Chairmen Irving J. SruKorF and E. Cuvli k Hammond CONTENTS Acknowledgments ..................... Introductory Remarks toy Marcus M. Krv Pari L ToMooIngirul Investigation^ of Vinyl Ohloriilu-PoH \ iuy 1 Chloride A. Clinical Similes Clinical Manifestations and Course of Vinyl Chloride Disease, toy G. Vlltman, C.-E. Langi:, S, Juhi , G. .S1 hn, and U. Bactini r................................... ... Further Results in Polyvinyl Chloride Production Workers, toy C.-L. Langl, S. Jumi , G, SriiiN, and G, Vi liman................................. .................................. Prevalence of Disease among Vinyl Chloride and Polyvinyl Chloride Workers toy Ruin Lius, Hlnky Andirson, William J, Nicholson, Susan Daum, An S, KlSCMlILlN, AND IRVING J. Si L1K0U-, . - ............ Changes in Pulmomry Function in Workers Expos'd to Vinyl Chloride and Poly vinyl Chloride, toy Aum ur Mii.li r, Alvin 5. T iusti in, Ming Ciiuano, Irving J. Sl.LIKOI F, AND RaRHAIL WahSIIAW, , , ..................... Clinical Manifestations in Vinyl Chloride Poisoning toy 1 Suciu, L. Pkooan, Elina Illa, A. Paduraru, and I.ivia Pascu Persistence ol Vinyl Chloride-Induced Liver Injury alter Cessation of Exposure. toy Paul D. Bi:kk, Jamls I: M vrtin, and Jiannt G. Waggonir , . Bone Lesions among Polyvinyl Chloride Production Workers in Japan, toy HmovuKi Sakaeh........................................... An Epidemiologic Study of Blood Screening Tests and Illness Histones among Chem ical Workers Involved in the Manufacture of Polyvinyl Chloride, toy Rom rt H. Wyatt, Jani, m. Kotchln, Donald L Hochstrasslk, Jack W. Buchanan, Jr., Duncan R. Camimilu., Josli'h C. Slaughtlr, and Alphonsl H. Doll. .. Liver Disease among Polyvinyl Chloride Production Workers toy John L. Crllch, Jr. and Laszlo Mark .......................................................................................... Unusual Splenomegahc Liver Disease as Evidenced by Peritoneoscopy and Guided Liver Biopsy among Polyvinyl Chloride Production Worker*, toy H. J. Marstll- llr, W. K. Lclhach, R. Mullck, and P Gldigk ., 6 18 22 42 53 70 78 80 SS 95 It, Experimental Muilie* Preliminary Studies of the Fate of Inhaled Vinyl Chloride Monomer in Rats. By R E Hi ks'lr, Ju , P G. Watanaul, and P. J Glhking..., Discussion of Preceding Paper, tov Gerald Cstlr ........................................................ 135 149 * This senes of papers is the result of a uorkihop entitled Ta\t.ii) of Vinyl Chloride-Polyvinyl Chloride, sponsored by The New York Academy of Silence*. the Amcri. an Cancer Society, the National Institute of nmiroitmcnlal Health Sciences. (he National Institute I'or Occupational Safety and HcjUh. And the Society for Occupational and Environmental Health and held on May 10 and ll, 197-1. yfai* A*. f Vinyl Chloride Monomer: Comments on Its Hcpatotoxicity and Interaction with 1,1Dichlorocthylcnc. By Rudolph J. Jaeger.............................................................. A Procedure for Preparing HC-Labclcd Vinyl Chloride. By Eugene R. Wagner and Wesley W, Muelder................................................................................................ Experimental Acute Toxicity of Vinyl Chloride (Monochlorocthenc) By Li:on PRODAN, I Suciu, V. PiSLARU, ELENA IlEA, AND LlVlA PaSCU Experimental Chronic Poisoning with Vinyl Chloride (Monochlorocthenc). By Leon PRODAN, I. SUCIU, V. PiSLARU, Ellna Illa, and Livja Pascu ..................... Hematogenous Dissemination of Ingested Polyvinyl Chloride Particles. By Gerhard VOLKifLlMER..........................*.................................................................................... 164 C. Pathology Alterations of Liver and Spleen among Workers Exposed to Vinyl Chloride. By Hans Popper and Louis B. Thomas.................................................................................. Part II. Carcinogenesis Associated with Vinyl Chloride A. Experimental Studies Carcinogenicity Bioassays of Vinyl Chloride: Current Results. By Cesare Maltoni and Giuseppe Lefemjne............................................................................................ Interim Results of Exposure of Rats, Hamsters, and Mice to Vinyl Chloride. By M. L, Keplinger, J. W. Goode, D. E. Gordon, and J. C. Calandra......................... B. Epidemiological Studies Mortality Experience of a Cohort of Vinyl Chloride-Polyvinyl Chloride Workers. By William J. Nicholson, E. Cuyler Hammond, Herbert Seidman, and Irving J. Selikoff....................................................... .................................. Characteristics of Cases of angiosarcoma of the Liver among Vinyl Chloride Workers in the United States. By Clark W. Heath, Jr., Henry Falk, and John L Creech, Jr.................................................................................................................. From Mouse to Man--or How to Get from the Laboratory to Park Avenue and 59th Street. By Marvin A. Schnuderman, Nathan Mantel, and Charles C. Brown............................................................................................................. Two Possible Cases of Angiosarcoma of the Liver in a Group of Swedish Vinyl Chloride-Polyvinyl Chloride Workers. By David Byrn and Bo Holmuerg___ Comments for Opening of Discussion on "Neoplastic Effects " By Thom**'. F. Man- cuso............. ............................................................................................................. On the Possible Mechanism of Carcinogenic Action of Vinyl Chloride. Bv Benjamin L. Van Duuren............................................................... .......................................... C- Pathology Pathology of Angiosarcoma of the Liver among Vinyl Chloride-Polyvinyl Chloride Workers. By Louis B. Thomas and Hans Popper ... Morphology of Liver Damage among Polyvinyl Chloride Production Workers. A Report on 51 Cases. By P. Gedigk, R. MOller, and H. Bechtelsheimer Part III. Environmental Considerations Measurements of Vinyl Chloride from Aerosol Sprays. By Bruce W. Gay, Jr., William A. Lonneman, Kenneth Bridbord, and John B. Moran. Environmental Concerns beyond the Workplace. By Glenn E, Schweitzer. Discussion Paper. By Morton Corn Experience in Industrial Exposure Control. By V. K. Rowe 3J 99 w Surveillance of Workers wi A. Mazzocchi, and I Clinical Management of W /^'Clifford A. Johns Discussion Paper. By Rich A Bibliography on the Tr Harry Heimann, Rut Thin monograph was :i American Cancer So*. Industrial Union Dep Mount Sinai School grant from the N to vl. L. 'kcrs. and rkcrs (N L. vIan- CO