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Microbics saltof PFO ---I'@.--.-.1. pownwo MICROBICS MICROTOX@ TOXICITY TEST TEST SUBSTANCE Identity:PerfluorooctanesulfonaLtiet,hiumsaltm;ay alsobe referredto as PFOS LisaltF,C-94,orFC-94-X. (I-Octanesulfoniacid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadeclaiftlhuiourmsoa-l,t, CAS # 29457-72-5) Remarks: The testsample isa mixtureofthetestsubstanceinwater (approximatel2y4.5% testsubstanceand 75.5% water).No calculations were made to adjustfortheactualconcentratioonfthetestsubstancein the testsample. METHOD Method: MicrobicsMicrotox@"BASIC" Procedure Test type: Staticacute GLP: No Year Completed: 1994 Species:Photobacteriupmhosphoreum Analyticalmonitoring:pH and osmoticcondition Statisticmaelthods: EC1 0 and EC50 valuescalculatebdy statistical linearegressionprogram providedforMicrotox@) Test organism source: Microbics,Reagent Lot# AM025. Test conditions Dilutionwater: MilliporMeilli-Q"wmater Stock and testsolutionspreparation:A primarystocksolution was preparedindilutiownaterat2000 mg/L. The pH ofthe stock solutionwas then adjustedfrom 5.9to7.0using0.02N NAOH and an osmoticadjustmentwas made using200 mg NaCl dissolvedin 10 mL of stocksolutionA.ppearance oftestsolutionwsas noted as "clearand colorless"A.lltestsolutionwsere made by proportional dilution. Exposure vessels: 3 mL glasscuveftes. Number of replicates:2 Number of concentrations:Four concentrationasnd controls Element basis:Percentlightloss RESULTS Nominal concentrations:125,250,500, 1000 mg/L Element value: 15-minuteECIO = 564 (367-866)mg/L 15-minuteEC5o = >1 000 mg/L 30-minuteEC,o = 487 (320-738)mg/L 30-minuteEC5o = >1000 mg/L Remarks: Values reportedareforthetestsample. No calculations were made to adjustfortheconcentratioonfthetestsubstanceinthetest sample. CONCLUSIONS The testsample containing24.5% PerfluorooctanesulfonaLtiet,hiumsalt exhibiteda 30-minuteEC50 forPhotobacteriumphosphoreum of >1000 mg/L. Submifter: 3M Company, EnvironmentalLaboratory,P.O. Box 33331, St..PaulM,innesota,55133 I'@, DATA QUALITY ReliabilityK:limischranking2. Thisstudy,whilewellconducted,lacks analyticadlata for:determinatioonfthe testsubstanceconcentratioinnthe testsolutionsa,nd determinatioonfthesample purity. REFERENCES Thisstudywas conductedby the3M Company, Environmental Laboratory,Lab Request number M 1018,2/07194. OTHER Last changed: 512/00 ENVIRONMENTAL LABORATORY MICRO131CS MICROTOXO TOXK:ITY TEST SAMPLE: FC-94-X LR M1018 JBD 2t7/94 Test Conc. (mg/L) 125 250 500 1000 EC50, mg/L (95% C.I.) PERCENT LIGHT LOSS OF P. phosporsum AFTER: 5-Minf,fa=&ule 15-MinE.j=sure 0 0 0 2 > 1000 7 5 9 15 > 1000 8 7 10 18 > 1000 ample Desc.-iption LA Page ot Environmental Lab - Work Sheet Oate: M e-t@\ Analysol: o L GCX) . \CL\ CA C- 0 A@ ci-C-\N) L c,-\e-,z c@O H @r\ \C) Y"A c,C,-\/, :vl-TCROTOX DATA REF:@OR! FILE NAtoIE:MlolS.K30 TEST DAT;:'. Li TEST TilmE.. Inves-i--i-aator: Samc'@e Description: M4@crotox Testina Approv,:---dov: o-F Procedt-,,re-.BASIC Osmo@'-ic Adjustmen"-: NaC! Initiaj' Concentratior, ma/L Test Time-. 30. mit-iutee Fi. ----- I TT ------------ DilLtt'LonFactor : 2 Un,-;ts.-ma/: C 0 NL-,* ---------- GAMMA --------- .i 97 .94/' /r7.IJ5 2 97.7-7! 75.86 125.0000 5 .00 O@07276 O.Oq498 CONTROL 'o-9.54/ -/3, ie- 2 5 0. t) 4 7 5 96 .4/ 4 5()C, C, qC,.-57/ 71). 2.'_:' 5 0000 7 93.75/ 64.43 1")Ot@j,.()Ooo .3 9"4.2t*e' 64.48 1000.000i@ IT@'IO = q6.69 63.78/ 97.62-p* 0. 0-'!140L7# 1 244 0.11509!@ 0. c)9495-4 (D.'-73597# 0.24)221# RATIOS = @34()6 0.2532w* CORRECTION FACTOR = ).C-494 10 ZD DDDDDDDDODDDDODDDODDDDI--, .3SI-OPE O.C-6(--@7 3 C, 3 A m A ODDDDDDDDDDDDD DDRM-DDDDODODDD DD ODD D? .3 .3 3 3 1 >zzzzzzzzzzzzzzz--:,zzz-7zzzzzzzz-. .3 .3 .3 .3 ..10 ODD 100 a 4 6 DDDDDDDDDDTDDVDDD-DDDDVD 1000 E5 DDD. DDT)DDDDDD-DDD CONCENTRATIQI* lOE4 3 '7 3 .3 -T)D,-,!)DDDDL.-)-V,D7DDDDY I C)E (95% CON*R-IDENCE RANGE: 600.'7Sa6 7r--'I'l-5462.l@29-@i) STATIS71CAL REPORT FOR DATA FILE Mlt)18.e*--Ii) ESTIMATING EQUATID.N.- :-OC-0 r@.8:351 x LOrz b NUMBER OF DATA PAIRS US=D.- 6 RE=TD;_iA'- ITANCE: 0.0254C- 95% CONr-IDENC;-r r-ACt--"-iR-5..07*----,2-FlOyR EC5o CC.RRE'@-AT--C!N @:'-)Ei--;z'LCIENT@,:R U-@IEFFTCT@;4T OF DETERMTNATION: R"'@2 O@74379 EFFECTIVE CONCENT7<r,--i!ONS (95% 'L-ONFT-'-."E,,RiACNEGE'T. EC50 EC20 ECIO =-)048.3767 = ?57.7f-96 = 466.5695 = 65.6808 ina/L ma/L mall mci/L (600.9,231"Z Tlr_'"jf'..'L5462.1i.E3*q5l**4 (474.9458 TO l@931.4671-I-) (3c@-0.5834 TO 738.4969) 1(:).7405'TC, 4C,1.6@@49)*** E X.-.i-"--@APOLATEA---'-.;-7.SUT'S INIT'.RAL DATA I\iljlv',BER 1 X3 4 5 6 CONt@,@CNTRATION 4L 2 -=i'tr.0-)o 0 .4L25.0000 25(.).01)0 0 25'--'. 500.0000 500-0000 io0i).0000 10()0.0()Ot@ 0 i@3 )95 0.04t) o0.. 11@-,:? il=i -d.1)95 (@j.27@6 IS K3 0 EFi=l-=CT 6.7PS.67 3.6-2 9.85 10.32 8 .ez'7 19. .@)9 16.62 7.7::, 6.86 9.5.,-) 'L7.96 ii-.cf-L-i-CTouch SPAC-M BAR 10 'IICRL '@@X DATA REPORT FILE NAME: NIOIS.K!5 TEC,[-'L-ATE.- TEST TIME: Aporaved by; -zamole Descrioti oFi: Microtox Testina of FC-3l't-X Procedure: BASIC - Adjustmen"--: NaC!- iriit4-al Concentration : IOC%.,r"r,a/L Dilution Factor 2 Test Timel- 1&5 minutes ancentration Uii-ts.-ma-I.L NUMBER i(.)/IT ------------- cor4c. ---------- 13AMMA --------- @l 97.34/' ?'6.80 2 97.79/ 7t.09 96..@il-77*4@l' 3C'2.54/ 7--,,-:15 6 -iO.53/ 69.03 7 93.75/ 65.86 c- 9'L . @C-6/ 6Z-:. J.4 i 0000 12 C,, 0 0 2 5 0. 0 0 . i)0 0 0 .5()C). ioo().O()00 1ooo., 0.,),.)o 0.06503 (,*@ C,@E-76i o.o2al7# .97 2 2 ().09912# o.09526# 0.188814 17()432# Ot'--NI'ROL1-1/10 = 80.4-6/ 96.69 97.62** RATJ@OS = i).-.I-F--.r71- CORRECTION FACTOR = O.A-351 iO ZDDDVDDDDDDDDDDDDDDDDDVDDVDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD? 3SLORE .3 1:1 .3 r_. .3 3 J. -,Z.,-r-@ZZZ-T@-"-@-@zzzzzzzzzzzzzz_lzzz-. 3 :EC5,) .3 4 6 .lo ODDDDDDDDDDDDDDDDDDD@DDDDDDDDD.DDDVDDDDD"-DDODDDDDDDZ@IDDDDDDDDY iCIC, 1000 CONCENTRATION I'--,E4 .3 .3 .3 .3 1t)E5 E 05o7(";P6. -?5*1'.CON7*-'DENC:--- @@jiANG-E.- TI-@j%l@@-917.8008) Used calculat4@cr-a ETA-irIET'@LCAL REPORT FOR DA-grA FILE M101E.K!5 ESTIMATING EQUA'7!CN: LOG C = 0.7754 x LOG b +3.4?05 NI-'PMBER OF DATA PA@rRs U-OEL,f: 6 RESIDUAL VARA'.ANCE.- ?5% 'L-,L-JNFI!-WC@F-ANCCTEOR: 5.1401a FOR EC50 C't@a'-%'RELATION R-'CEFF ILC TLENT: R 0.047@0 COEFFICIENT OF DETERMINATION: 0.7*@Lti76 EFFECTIVE CONCEN-IRAYIONS (95% CONFIDENCE Rf-@NGEI: EC@'O =3096.7422 EC20 =1056.9373 ECIO = 563.5806 ECO-1 = S7.7866 MO/L mall ma/L ma/L ( 602.4564 TO ( 488.4282 TO -:-6'0.85e@-T2O 865.8c.-167) 13.3214 -17'042c).6264)*4@* -cXTRAPOLA'@-ED @,'E:--"t-"LTS I-N-@TIAL DATA 2 3 4 5 6 7 CONCENTRATION 125.0(:)00 125.000o 250.0000 250.0000 500.0000 '1020a@.C)0 (-@.)1, .1000.0000 GAM.viA 0 @,)65 O.OGP- 1).087 0.0917 0.095 O.J.69 o.'L7C, mioi C-. 5 EFF=-CT @.74 8.02 13.@@-)4 S. 7,") 7 a.;36 i-:4iL CCCCTouch mmilim mllill-immm lltmii Pito,;itilim PY flif kt/IMMIlilmm il SPACE BAR to continue.... V VXi % I MIS@-ROTr-'X DA'I'*AREPORT FILE NAME: M1018.K5 TEST DA7E: T@nvestioator: TEST TIME: Aooroved bv.- S,::tmoleDescrioticn: Microt@ax Testine of FC-?4--A Procedure: BASIC initial Concentration : 1000 ma/L Test Tirrie-.5 minut*es NUMBER ----- J@O/IT ------------ Osma'iz Adjustment; DilLt4,ionFactor : 2 Co-icentra4-.;-onUnits: c 1-1c1!N ---------- GA!Oti!A --------- i ?7.94/ 85.74 12 97.79/ 83.68 3 Sq-54/ 80. 4 7- 82.60 5 8 4,.114e 9().Z::.8/0.46 7 q3.75/ 77.91. A 91.26/ 7$3. 10 -'.GN7ROL IT/IO = 6'-7,,959/6.69 RA-'Jv:D-0= ).8579 CORRE%@ITION FACTOR = 0.8587 4--25.0000 25. Ot)O,) )00t-',, 0000 50t).()ot.,C) io0o.ilao0o1000.0ooo 63.ql@/ (?-f.62-"* o.Bff96** -0.01-90--D* M 00352* --0,04506* 0.00667* -0.017674 -O.4'j3404* 0 -0.@1332 0 .0 0 3 NaC! ma/L cx 4fneaLs- ..........N.O TOXICT LTY Af U-ONCENTRATIONSTESTED Invali@-: r--'ataor controis ...14-ITIALDA'TA N U M F, CONCENTRATION 125.004)() 2 125.0000 2 5 0 -X) -z50.OOOO C@ 500.0000 6 500.0000 7 l@000.000() 1000.0000 7 ZNVALTLD DA-ra PEMOVED ,III Ifl1-1mI!i-ii-I (BA@IMA -O.o!9 0. @",04 045 0.007.'* -0.034 - 0.033 0.003 FOR C A L C U 0 @N' @l4L@)1,3.K5 !il."IIM"IliiiIif-iIIili7 EPFER-T -'t.72 0.66 -1.82 -3.52 3.22 r;.34 -0. at) -2.67 1.76 4-;,-CCTouch SPACE BAR 4%-ocontinug. ...