Document n9kOBanV7Gnp5ebb9EEDKDVkX

August 12, 1950 Mr. L. F. Wagner, Chief Chemist, The Clidden Company, Reading, Penn. Dear Mr. ."agner: In r eply to your l e t t e r of August 3, 1950, I may say that our work consists primarily in making toxicolog ical investi g a t i o n s of compounds use d in industry. `7e em p l o y our facilities for analytical work only to the extent that is necessary for furthering our toxicological work. In the course of our work we have had frequent occasion to advise manufacturers of fo o d containers as to the steps to be taken in order that they m a y be able to furnish n e c e s s a r y i n f ormation as to the toxicity of plasticizers for food wrappers, ingredients of lacquers for f o o d containers, etc. \7e u s u a l l y suggest that they secure I n formation in their own or another chemical laboratory as to whether or not the material In question enters into food kept in contact with coating containing it. They then present their evidence to the Food and Drug Administration directly, and, if they agree that none is present in the food, its use m a y be a p proved. If, however, the chemical determinations should prove that the product enters the food in ueterminable concentrations, we may then undertake loxxg-teim experiments in which the material in question is adued in tnree or four known c o n c e n t r a t i o n s to all of the f o o d f u r n i s h e d respective groups of rats and dogs. The results of such experiments supply evidence u p o n -which the Food and Drug n d m i n i s t r a t i o n m a y case their c o n clusions as to whether the amounts found in the food in tests conducted elsewhere will be deleterious. Because our analytical staff Is at present over burdened with work, we are unable to un d e r t a k e the chemical p o r t i o n of such investigations. If, however, you secure evidence elsewhere that the material you have under consideration does enter food stuffs, we should be glad to discuss with you the question of undertaking the toxicological Investigation of the material. Ifr 0 00553 Mr. L. P. .Vagner -2 August 12, 1950 Your impression that we have performed chemical work on steel containers with baked organic coatings probably has Its basis in the fact that some years ago we did a little work of the sort you mention at a time when we were designing experimental chambers in which to confine animals in testing the toxicity of vapors at atmospheric contaminants. Yours very truly. FFH/mjg Francis ?. Heyroth, M.D. assistant Director The Gmowkjt Company STPECTS R k a j j i x o ,P k x x a . August 3, 1950 Kettering Laboratories for Applied Physiology University of Cincinnati Cincinnati, Ohio Attention: Dr. Robert Kehoe, Director Gentlemen: We understand that you have run extraction tests on materials contained in steel containers that have been coated with organic baked coatings, and that you are familiar with the procedure. In connection with our business as paint and varnish manufacturers we have developed coatings for steel containers, these coatings being baked on at fairly high temperatures, which makes them practically insoluble in ordinary products such as water, lard oil, oleomargarine, etc. These coatings are for the most part, or almost exclusively, non-toxic. However, the pure Food and Drug Administration and the Bureau of Animal Industry in certain cases request that we have extraction tests run on these coatings and suggest as representative materials hot lard or oleomargarine in one case and water in another. Therefore, what we would propose to do would be to send you containers coated with organic coatings and then have you subject them to contact with lard and water for a period of, say, 30 days at room temperature. You would then test the lard and water to see what, if anything, of an appreciable nature had been extracted from the baked coatings. If you are set up to do this work and have experience with it, we would appreciate your quoting us as to the cost for running several different coatings with these materials mentioned and possibly a few others, such as Coca Cola syrup and tomato juice. We would appreciate your prompt attention to the above, 3ince it is a matter of importance to us. Yours very truly, LFW y