Document n9ej3MzN66oGEe1QqeKJ8mwoG

work! facxl' $: Wj* 'w % ifte -23- j-iy CASE STUDY 3. VINYL CHLORIDE - REST AVAILABLE TECHNOLOGY by Donald V. Lassiter, T'K'.iT^^^ccupationaX Safety and Health Administration, Washington, D.C. ite yea res due ligna profi of ca VC. bers , Promulgation of a standard regulating occupational expo *.. sure to vinyl chloride (VC) by OSHA on October 4, 1974, marked the initial Federal attempt to regulate occupational repor revie prima exposure to a carcinogen on the basis of available ana lytical methodology. Demonstration of carcinogenicity of VC had included experimental, animal studies performed by separate investigators and a continuing case list of human cancer in workers occupationally exposed to VC. Although various tumors were observed both in experimental animals and in occupationally exposed workers, the finding of angiosarcoma of the liver in both instances revealed a def inite correlation between chemical exposure and induction of cancer. The significance of polyvinyl chloride (PVC) production to the Nation's economy rendered impractical Whe males anime in te of th 33 S (/> ONC o rtIOon VINYL u o> even de_ facto elimination of this important industry through unattainable controls prescribing ''zero" employee exposure to VC. Rather, exposure to VC was limited to one ppm as an 8-hour TV/A and 5 minutes as a / 5-minute TWA. The one ppm exposure limit was based on recommendations made to OSHA by NIOSH and represented the sensitivity of available ana lytical methodology for determination of compliance. 1 cantfl the' p occur in ,4 rat el werp of si malfc a noma 5.62$ f Indi prociu malfc possi m