Document n9ZwbVr1EeLNxE8RaMvr5ZOza

August 5 19 3 7 Mr. H , R. Wo lf'1' . Ch e m ical Re search. De partm e n t Research Labo rato ries D ivis ion I4B5 we s t Milw auke e Avenue D e tr o it, Miches an Deer Mr* Wo lf? 30So f a r a s I know, th e questio n rais e d in your le t t e r of Ju ly th concerning the s kin abso rptio n o f such o rgan ic le a d compounds as .haphthanat o r o le a t e , has n o t been s o lve d by experim en tal o bs e rvatio n s * I t seems im p ro bable t o ms t h a t an y s i g n i f i c a n t amount o f abso rptio n would occur as a consequence o f s kin co n t a ct Tilth lu b r ic a n ts c o n ta in in g s u ch compounds* Th e re fo re I doubt th e e x is te n c e o f any s i g n i fi c a n t h e a lth h azard s from the normal h an d lin g o f such lu b r ic a n ts * I t i s q u ite p o s s ib le th a t seme abs o rptio n does o ccu r, tho ugh I sh o uld e xp e ct i t to be o f th e ra p e u t i c im p o rtan ce o n ly* On th e o t h e r h an d , i n a s much as th e r e a re no d a ta w i th w h ich I am f a m i l i a r , w hich would s e t t l e th e m atte r c e r ta i n ly , th is state m e n t must be re ga rd e d a s an o pin io n b a s e d on h y p o t h e t i c a l re as o n in g ra th e r than any p re c is e knowledge o f the fa c ts * I f th e pro ble m i s on o f c o n s i d e r a b le im p o rta n c e , I sho uld th in k th a t some e xpe rim e n tal o bs e rvatio n s in se arch o f the fa c ts m ight w e ll be ju s tifie d * Very tr u ly yo u rs , RAKiis R o b e r t'A* Ke ko e ,' *t>* He 0\)0<G54 N7986