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-*e SPECIAL PROGRAMS NEWSLETTER CHEMICAL MANUFACTURERS ASSOCIATION 2501 M STREET NW. WASHINGTON, DC 2003? 203/SB7.11OO Volume 4, No. 2 BEGINNING THE BEGUINE WITH SARA eived ,u_ DR. A. i-- r-1 iVM;r' The Superfund Amendments and Reauthorization Act (SARA) was signed into law last October. The Act contains extensive new provi sions on health related authorities which could result in enormous costs for individual companies. An understanding of the requirements in Title I, Section 110 is critical for any person responsible for the manufacture or fate of affected chemicals (listed on the next page). Can you do anything if your chem ical is on the Section 110 lists? Yes. Soon. Read on. The Agency for Toxic Substances and Disease Registry has primary respon sibility for the health related authorities, with some EPA involve ment. Section 110 gives ATSDR responsibility in four areas: Hazardous Substances List and Toxicological Profiles. ATSDR, along with EPA, must list 200 substances by October 1988 and 25 substances per year for the subsequent three years. The list, shown on the next page, of the 100 most hazardous substan ces found at waste sites was published on April 17. For the first 25 chemicals (Priority Group 1), toxicolo gical profiles that identify data needs and set significant human exposure levels (SHELs) will be developed by October 17. Profiles on chemicals in IN THIS ISSUE Proposition 65 Update . . . . 4 TSCA/RCRA Engagement Announced ............................... Spotlight: Biocides . . . . 5 News Briefs ............................... People ........................................ New Programs .......................... Recent Releases Special Program Comments .......................... Federal Register Notices. .12 Final Reports ...................... Priority Groups developed over period. 2-4 will be a three-year SHELs will be used to calculate potential risks for populations near waste disposal sites and could have significant liability implications. ATSDR has not yet determined criteria for setting SHELs. BOR 007426 *************************************'******************************** * * * * ** * * ATSDR PRIORITY LIST OF 100 HAZARDOUS SUBSTANCES * ** k* ** * Priority Group 1 k k CAS NO. Subatanca nama k k k k 50328 53703 56553 6507517215 BOaibnaznozlatXlpayi.rnainaanthracana CByaamrundtaaianthraeana Oialdrin/aldrin k 67663 7715403124 Chloroform VBiannyzl acnhaton*da k k 75092 7769404166 MHaapintyaicaMnaare/hhalopnUdcahlar aponda TricMoroathana k 18066340667. N1,w4*wOriacaMooOrapthoaannzyaianmana k 211021577916961247 BTaiatr(a2c-awvoiyroihathiyaf)npahihalata Banzo(b)fluoramnona k k k 1271485001196 Chryaana P-Olon 77443490902210 LNoicakdal k 77444400346127 BArearaylnliwum k k 7440439 7440473 11196625 CCPahCdrSom-m1iui2um6m0.54.46.42J2J21.1016 Priority Group 2 CAS No. Subatanca nama 56235 Carbon tetrachloride 6527775499 Crtfhwtorordaaontaamatnytamm* 72559 4.4--OOE DOT. OOO 75003 75274 Chloroathana Bromocftetiioromstftar* 75354 1.1-Oicftlotoatnana 7788589715 t1a,o2p-Dniocrhotnoaropropane 7799040355 11..11.,22.-2T.nTcehtlroarcomamoraoneatna.ie 9617984615 P3,a3n'-tDacicnnioiorrooponaannzoidl ina 11900278806768523 B1,a2m-Odicinhaioroeman* Toluana 110161945424 PBhiUa2n-ocinioroemyl)ether 121142 2.4-Oimirotoluen* 319646 564221668417 BBHiC(e-amJoprhoam. aotahmy!m)aam. abreta. dalta N-nitroodi-n-propylamine 7439976 Mercury 7440666 Zinc 7782492 Selenium * * * * * * k * k k k k k k k k k k k k k k k k * * Priority Group 3 Priority Group 4 k k k CAS No. StUatanca nama k * 7714567536 1.1,1-Inchloroathana Chtoromamana * * * 7755221582 Outran* Bromolorm 8745734432 D1,i1-N-O-bicuhtyto! rponatthhaalnaata 66062 2.4,6-Tncniorophanol 91203 Napthaiana k 98953 Nitrobenzene k 100414 107028 EAictrryoilbaainrizana k k k 111010706179340117 Acrytommia CHhalxoarCobMeonrzoeonaenzon* 112242466617 156606 1,2-Oiphanyihydrazina C1.h2i-oTrroadnUar-odmicMomOerothaathnaen* k k k 1631039603223009725 7221934 7440224 tndeno(i ,2.3-cdlpyrene 2.6,Oinrtfotoiuene Total xylene* ESnilvdeitrn aidanyda/andrin 7440508 Coppar k 7664417 Ammonia k 8001352 Toxaphena CAS NO. Subatanca nama 51285 59507 62533 6675782510 2.4-Oirtrophenoi PA-nCilihnieorcMivcraaol Banzoic acid Hexachioroethane 74839 75150 CBraormboonmdiastuhlafindaa 75694 75718 6748696323 2FD-liBuchoulrtoaorntonodcninl*hiioorroommeaninnaen* Diathyl phthalata 6875061883 95487 95501 110085160719 Phenanthrana HPtaiaxnaocnl,2io-rmab*tuntyalowna 221,.-42P--eODniicmt*hnaloothrnoyeblp,ah4na.zMneo*nltehyt 120821 1.2.4-Tnchlorobenzena 120632 2.4-Oicmoropnanol 112331911113 206440 1.4-Oioxana DFliumoaratnnytthpehntehalata 553441572311 7440280 T41.,h63u--OOhuiicnmnitlroor-o2o-man*zihaynlapnanol k k k * k k k k k k k k k k * * k k k k k *********************** k BOR 007427 ATSDR's handling of the Priority Group 1 chemicals will set prece dents for the remaining Groups and future listings. In parti cular, the toxicological pro files for these first 25 chemi cals will serve as standards for data evaluation, determination of data needs and methods for setting SHELs. Health Effects Research. Where adequate information is not available on the health effects of a listed chemical, ATSDR, in consultation with EPA and the Public Health Service, must initiate a research program to fill the data gaps. The program must include studies to determine short and long-term health effects. ATSDR has not yet determined the mechanisms for accomplishing the studies. One solution mentioned is requirinq manufacturers and processors of the chemical to bear the costs of research. This overall expense could dwarf current toxicological testing costs under Section 4 of TSCA. Health Assessments. ATSDR must perform a health assessment for every site on the National Priorities List by December 1988. A health assessment is a preliminary estimation of poten tial risks to human health posed by an individual site. Ultimate ly the health assessment will help determine whether action should be taken to reduce human exposure and whether additional information on human exposure and health risks is needed. ATSDR states that the average cost of a health assessment is $4,000 per site. Costs of conducting health assessments may be paid initially from the Superfund trust fund and subse quently recovered from responsi ble parties. Further Health Studies. ATSDR may conduct pilot or full scale epidemiological studies based on the results of the health assess ments. ATSDR estimates that the cost of a pilot study will be at least $30,000 and a full scale study will be at least $100,000. Like the health assessments, costs of these studies may be paid initially from the Super fund trust fund and subsequently recovered from responsible parties. CMA's Hazard Assessment Task Group has drafted comments on the April notice. The comments point out the shortcomings in the selection pro cess for listed chemicals. CMA also asks that the toxicological profiles contain a critical evalua tion of each health effects study, include all relevant positive and negative studies, and use a weight- of-evidence approach in drawing con clusions on the effects of the chem icals. In addition, the comments recommend that several risk approaches be used to determine the SHEL and that a range rather than a single value be selected for the SHEL. What should you do? First, if your company's chemical is listed in Priority Group 1, you should submit significant data quickly to the EPA contractor responsible for preparing the profile. You also can nominate profile peer review ers. These reviewers must have knowledge of the chemical and not have a conflict of interest. Nomin ations can be sent directly to ATSDR at Building 28 South, Chample, 1600 Clifton Road, Atlanta, Georgia 30333. A 90-day comment period following publica tion of the toxicological profile will allow another opportunity for input later this year. If your company's chemical is listed on Priority Groups 2 through 4, BOR 007428 comments and unpublished data should be sent to Document Control Officer, OTS, EPA Room NE-6004, 401 M Street, SW, Washington, D.C. Representatives from affected panels will be invited to a SARA Inter-panel Coalition meeting on August 6. The agenda will include briefings on current status and consideration of strategies for joint actions. Affected panel mem bers should contact their program manager for further information and advice. E. Moran L. Ramonas PROPOSITION 65 UPDATE Recently, representatives of eleven panels met to discuss means of addressing specific chemical concerns during imple mentation of the Law. The Prop. 65 Coalition will meet again on August 5 at CMA to develop strategies in conjunction with the CMA Toxics Initiative work Group. Interested persons should contact Dr. Elizabeth Moran at 202/887-1182. The Director of the California Department of Health Services, Dr. Kenneth Kizer, recently called Proposition 65 the "wave of the future." He predicted that most states will adopt similar legislation and that nearly all states with an initiative and referendum process will eventually have it on the ballot. Meanwhile, California's Health and Welfare Agency continues to develop regulations to implement the new law. A court battle is ongoing to determine the statu tory listing of carcinogens and reproductive toxins. The Governor's office has filed an expedited appeal to the recent state Superior Court ruling that increased the list to over 200 chemicals. It is anticipated that the recently appointed Science Advisory Panel will add chemicals to the list regardless of what happens in the lawsuit. The Agency is polling state and federal agencies to ascertain which chemicals should be labeled as carcinogens or reproductive toxins -- criteria for listing under the Act. Undersecretary of Health and Welfare, Thomas Warriner, has established three ad hoc committees to advise him on specific areas of regulation: environmental warnings, product warnings and discharge prohi bitions. Representatives from state and local governments, public interest organizations and business form the membership of these committees. Business and industry groups, meeting through the Environmental Working Group, are commenting on the regulations and developing papers on issues and defini tions related to implementation of the law. The CMA State Affairs Committee continues to monitor implemen tation of the Law through the California Chemical Industry Council. The Committee is parti cularly sensitive to possible precedents for other states. You should be alert to any Proposition 65-type issues (either ballot initiatives or proposed legislation) and keep vour state organization, as well as CMA. informed. The CMA con tact is Joan Riley at 202/887- 1268. Joan Riley Manager, State Issues, CMA BOR 007429 TSCA/RCRA ENGAGEMENT ANNOUNCED In the March Newsletter we reported that a TSCA Section 4 test rule was expected soon from EPA which would require industry to pay for testing 73 chemicals of interest to the Office of Solid Waste. The proposed test rule was published in the Federal Register on May 29 (see Recent Releases Section). The required data is intended to support EPA's hazardous waste "relisting" program under the Resource Conservation and Recovery Act. Relisting is an effort aimed at determining the concentration of a waste constituent, below which no significant risk is associa ted. Establishing this concen tration will allow the continued disposal of wastes not consider ed hazardous in landfill facili ties. The Agency is proposing that current manufacturers pay for the required testing. This may be contradictory to Section 4(b) of TSCA which states that the activity for which the Agency makes Section 4(a) findings determines who bears the responsibility for testing. In this case, disposal is the acti vity of concern, not manufac turing. EPA also proposed that for chemicals no longer manufac tured, testing would not be required until manufacturing is resumed. A threshold volume, below which testing would not be required, is being considered for small quantity research and development chemicals. Comments on this proposed rulemaking may be submitted to EPA until July 28. The CMA Health and Safety Committee has estab 5 lished a TSCA/RCRA Ad Hoc Work Group to address generic con cerns raised by the proposal. CMA comments will focus on the statutory requirements of TSCA and the category approach taken in this rule. Concerns on specific chemicals will not be addressed directly by the Group, however these issues may be included as examples or submit ted as attachments to the CMA comments. Affected panel mem bers may work through your Special Program to develop comments. Others may contact Nancy Doerrer of CMA (202/887- 1282) to coordinate efforts through the Work Group. K. Rosica SPOTLIGHT: Biocides This is the seventh of a series, highlighting the activities of various Special Programs. Manufacturers of industrial biocides formed a Special Program in 1988 to address the California Department of Food and Agricul ture's Data Call-In on over 700 pesticidal chemicals. Since then, the Panel has commented on the need for data generation, data compensa tion procedures, and data confiden tiality provisions. Now the Panel has expanded its focus to address regulatory issues affecting biocides at the Federal level. Currently, the Panel is chaired by Jane Yuster of Troy Chemical Corpor ation. Claude Wolf of Nalco Chemi cal Company is the Vice-Chairman. One of the Panel's primary objec tives is to persuade Federal and state regulators that non-agricultural pesticides should be regu lated differently from agricultural pesticides because exposures to industrial biocides are very limited. Also, markets are small and the economic impact of regula tion on the biocide industry is much greater. BOR 007430 California. The Panel estab lished five chemical-specific task forces -- Arsenic Acid. Creosote, Mercurial Compounds, Naphthenates, and Copper-8 -- to address the Data Call-In. The task forces first provided comments giving reasons why the testing required by CDFA is not necessary. This February, representatives of the Arsenic Acid, Creosote, and Copper-8 Task Forces met with CDFA. During the discussions, CDFA staff conceded they had not reviewed all the previously submitted material. Subsequently, the Department issued an errata sheet indicating that conclusions in its report to the legislature concerning arsenic acid, creosote, and copper-8 may not be correct. CDFA currently is reviewing the task forces1 c mments, and will issue a new decision soon. Antimicrobial Testing. In March, EPA initiated a data call-in on approximately 300 antimicrobials. The Agency believes that subchronic t xicity data are necessary to evaluate potential health hazards. In April, the Panel invited all EPA registrants of antimicrobials to a meeting to discuss the industry's options for responding to the data call-in. As an outcome, the Panel has submitted several comments to EPA outlining legal, technical and economic problems with the call-in. The Panel believes that completing exposure studies before establishing toxicological require ments would be more logical from technical and economic stand points. Currently, EPA has only arbitrarily placed chemicals into hic^i, medium, and low exposure categories. The Panel now has formed exposure assessment task forces to address several end-use areas. e The Panel plans t work with EPA in developing a rational research program and minimizing the negative impact on the industry. Inorganic Arsenicals. On April 7, EPA issued under FIFRA a special data call-in notice on wood preser vatives containing in rganic arsenicals. The Agency required protective clothing permeability studies on the arsenicals and a teratogenicity study on arsenic acid. The Arsenic Acid Task Force will sponsor the required studies. Pesticide Inerts Policy. EPA has classified approximately 1,200 chemicals registered as inert ingredients in pesticide formula tions into four categories based on known, presumed, inadequate know ledge of, or lack of toxicological concern. The Agency's inerts policy was issued in the Fed. Reg, ^see Recent Releases Section). EPA also provides copies of its operating procedures for inerts on an as requested basis. The Panel closely monitors EPA's activities in the inerts area and plans to work with the Agency when necessary. FIFRA Registration Fees. Last November, EPA proposed rules defining fees for various pesticide registrations. The fees may run as high as $163,000 for registration of a pesticide and could place major hardships on small producers of industrial biocides. The Panel filed comments on the proposed rule, stating that EPA lacks the statutory authority to impose these fees, and even if it had the authority, the Agency failed to consider the economic impact on industrial biocide producers. EPA has not issued the final rule; however, there are indications that the Agency is seriously considering the Panel's comments BOR 007431 and may reissue a revised proposed rule. FIFRA Reauthorization. The Panel is monitoring FIFRA reauthorization activities in Congress. Specifi cally, the Panel is concerned with user fees, re-registration of existing pesticides, and assessment of monetary value for health and safety data shared among manufac turers. H. Shah NEWS BRIEFS FAVORABLE RULING IN DIOXINS/FORANS SUIT (Washington, March 30) EPA's "right to set its own priori ties" in the face of citizen petitions under the Toxic Substances Control Act was affirmed in a Federal court decision. The Court ruled that EPA need not refute the possi bility of unreasonable risk to deny a TSCA Section 21 petition. The Dibenzofurans/Dioxin Panel had intervened on behalf of EPA in the suit. The ruling by the U.s. District Court for the District of Columbia came in a lawsuit filed in 1985 by the Environmental Defense Fund and the National Wildlife Federation. The two environmental groups had asked the Court to reverse EPA's denial of their request to initiate a comprehensive TSCA Section 6 rulemaking addressing dioxin and furan impurities in products and in the environ ment. CHLOROBENZENES PANEL INITIATES TESTING (Washington, April 1) Panel members initiated testing required under the TSCA Section 4 Chlorobenzenes Health Effects Test Rule. EPA is requiring 7 oncogenicity testing in rats and mice on 1,2,4-trichlorobenzene; developmental toxicity studies and a two-generation reproduc tive study on 1,2,4,5-tetrachlorobenzene ,* and a reproduc tion and fertility study on o-dichlorobenzene. A reproduc tion study on p-dichlorobenzene will begin next month. Environ mental effects testing will start when EPA finalizes the test standards for the final rule. OSHA ISSUES GLYCOL ETHERS ANPR (Washington, April 2) OSHA published an Advance Notice of Proposed Rulemaking on 2-methoxyethanol, 2-ethoxy- ethanol and their acetates (see Recent Releases). This action follows EPA's referral under TSCA Section 9(a) and OSHA's review of the reproductive, developmental and hematological effects associated with exposure to these compounds in animal studies. The Glycol Ethers Panel is in the process of reviewing the ANPR and preparing a response by the July 31 deadline. EPA ANNOUNCES PCB RULE (Washington, April 2) After more than two years of discussions, EPA's Office of Toxic Substances finally released its policy/rule on PCB spill cleanup. The Notice contained many of the provisions sought by the Consensus Group of industry and environmentalists, but several areas still require clarification. The PCB Panel is considering comments. PHTHALATE ESTERS PANEL, CUT, HSIA MEET (Washington, April 29) Members of the Phthalate Esters Toxicology Research Task Group met with Dr. Jim Popp of CUT, bor 007432 and Dr. Dan Byrd of the Halogen- ated Solvents Industry Associa tion to discuss similar research plans on the class of compounds known as peroxisome prolifer- ators. Die groups plan to pursue research efforts that will further clarify the relationship between peroxisome proliferation and cancer, and help to determine the relevance of this data to humans. Dr. Derek Guest, Chairman of the Panels' FDA Task Group, was also on hand to discuss a testing program covering similar con cerns on di-ethylhexyl adipste. TRIETHYLKNE GLYCOL ETHERS leGOTIATIONS BEGIN (Washington, Hay 19) EPA announced negotiations for development of a consent agreement on testing of triethylene glycol ethers (see Recent Releases). EPA solicited public participation and announced its timetable for negotiating a consent order. The Glycol Ethers Panel has signed on as an interested party and has since met twice with EPA. The Panel already had initiated voluntary testing and submitted plans for future studies in their response to an earlier NPR. A decision by EPA on whether to use a consent order or finalize the test rule is expected at the end of June. EPA PUBLISHES "SHOOLD-SHALL RULE" (Washington, Hay 20) EPA pub lished a final rule that amends the test guidelines under TSCA Section 4 (see Recent Releases Section). In many instances substituting the word "shall" for "should" constitutes the only, but significant, amendment. EPA intends that these test guidelines become mandatory and enforceable when issued as standards in test rules. Flexi bility of the test protocol as applied to a specific chemical will be subject to notice and comment at that time. It now is more important to give close attention to all aspects of test protocols at the proposed rule stage. The revisions involve minimum requirements for test procedures, analytical measure ments, test conditions, animal selection, use of controls, number of dose levels, facili ties, observation period, adninistration of substances, observation of arimals, clinical exams, gross necropsy, histo- pathology and reporting of the data. The Fed. Reg, notice did not include EPA responses to public comments and several important considerations are not discus sed. The responses include commentary on technical aspects of specific test guidelines and were published in a separate April 1987 document of 155 pages. The document is avail able through the EPA Freedom of Information Officer; U.S. EPA; Mail stop (A-101); 401 M Street, SW; Washington, DC; 20460. MESITYL OXIDE TEST STANDARDS APPEAR (Washington, May 20) Final test standards applicable to the Mesityl Oxide Final Test Rule were published (see Recent Releases). The Ketones Panel will seek a stay of the testing until a decision is reached in the challenge of the Rule in the Fifth Circuit Court. Briefing has been completed in the case and oral argument is scheduled for July 7. In the event that the stay is not granted, the Panel is making preparations to BOR 007433 i * initiate the first tier of required testing. CYCLOHEXANE PROPOSED TEST RULE PUBLISHED (Washington, Nay 20) EPA proposed that manufacturers and processors of cyclohexane be required to perform testing under TSCA Section 4 for chronic toxicity, oncogenicity, reproduc tive toxicity, developmental toxicity, neurotoxicity, dermal absorption and dermal sensiti zation (see Recent Releases). The proposed rule contains the same test battery that EPA proposed in July 1986 when initiating negotiations for an enforceable testing consent agreement. The Cyclohexane Program Panel is preparing written comments due by July 20. A final rule is anticipated in March 1988. CRESOLS PANEL TO INITIATE TESTING (Washington, May 20) The Final Phase II test standards and reporting requirements for cresols under TSCA Section 4 were published (see Recent Releases). The Cresols Panel will submit study plans for the required mutagenicity, reproductive and development effects testing on o-, m-, and p-cresol. Testing will begin this July and will be completed in 1989. HDA PANEL COMPLETES MEDIATED RULEMAKING (Washington, May 22) A fifteen member Mediated Rulemaking Advisory Committee established by OSHA to develop a Workplace Standard for 4,4'-methylene- dianiline completed its activities. The MDA Panel was involved in this mediated rulemaking procedure from its inception. The Committee consisted of representatives 9. from industry, labor unions., and government agencies including OSHA, NIOSH, DOE, EPA, the Department of Labor and California OSHA. Two government contractors also participated. Industry representatives were Roger Daniel (Dow Chemical) representing the Panel, John Keane (General Electric) representing NEMA and Richard Champlin (Hercules) representing SACMA. The Committee met monthly, beginning in July 1986, to develop a consensus standard. The standard, which the Panel feels is quite favorable, will be published in the Federal Register as part of the Committee report. Within 90 days of the report publicati n, OSHA will issue a proposed rule for a workplace standard on MDA which is expected to parallel the Committee report. The final OSHA rule, if uncontested, will appear in mid-1988. FINAL HYDROQUINONE TEST RULE READY (Washington, May 28) TSCA Section 4 test standards and reporting requirements for hydroquinone were published (see Recent Releases). The Final Phase II test rule becomes effective on July 13. The final test reports on oral and dermal pharmacokinetics studies and neurotoxicity testing are due at EPA by July 1989. The final report on two-generation reproductive effects on the rat is due by December 1989. The Panel is working with EPA to clarify the test standards before beginning the required testing. PCB PANEL TALKS TO CONGRESS (Washington, June 1) Representa tives of the PCB Panel met with members of Congressmen Synar and Skelton's staffs, other members BOR 007434 of the PCB Consensus Group, and staff members from several EPA offices to discuss the Agency's intention to move PCB storage and disposal regulations from TSCA to RCRA authority. Some members of Congress feel that pCBs could be more effectively regulated under RCRA. The plan proposed by EPA's Office of Solid Haste would take up to two years to implement and could be potentially very disruptive. The Consensus Group feels it would be more efficient to strengthen TSCA rules to address the concerns of Congress. Group members have already outlined, in letters to OSW Director Marcia Williams, possible changes to TSCA that would improve the permitting of disposal facilities, manifes ting, and enforcement. The Group is considering further approaches to EPA. CPC ACTIVITY HEATS UP (Washington, June 1) NRDC and EPA have agreed to modify the timetable for proposing further U.5. regulation of chlorofluoro- carbons until after interna tional negotiations to control CFCs on a global basis have been completed. EPA now has until December 1 to decide whether further regulations (beyond the 1978 aerosol ban) are neces sary. Delegates to the UNEP negotiation session held in Geneva during May reached tentative agreement on a global protocol. Representatives agreed, in principle, to a cap on the production of as yet unspecified CFCs. The cap would be in place by 1990 and would h Id production at 1986 levels. A further phasedown is also being discussed. The U.S. position on the protocol is being hotly debated by members of the Reagan Administration. Some feel that it goes too far, too fast. EPA, the Department of State and some members of Congress continue to advocate stringent restrictions, including up to a 95% phaseout of all CFC uses. Interior Secretary Hodel reportedly suggested that people should take some personal responsibi lity in protecting themselves by wearing hats, sunglasses, and sunscreen to help decrease the number of skin cancers that are currently occurring due to exposure to ultraviolet light. Media coverage of the issue has increased tremendously, with many editorials and articles. The Fluorocarbon Panel is monitoring this activity closely. CUMENE PANEL RECEIVES DATA (Washington, June 2) The Cumene Panel received the final report on studies sponsored to clarify response to cumene in mutageni city assays. Cumene was tested in the Ames, chromosome aberra tions, unscheduled DNA synthe sis, point mutation, and cell transformation assays and was found to be negative in all assays under all conditions tested. In November 1985, EPA issued a proposed test rule on cumene. The Agency based the rule largely on the results of inadequate mutagenicity tests. The Panel will submit the new data to EPA in hopes that the clarified results will allay EPA's concerns. PEOPLE FLUOROCARBON PANEL LEADERS REAFFIRMED At elections held recently. Dr. S. Robert Orfeo of Allied-Signal Corporation was re-elected Chairman of the Fluorocarbon Panel. Dr. Gordon Diprose of ICI, PLC. was also re-elected BOR 007435 * to another term as Vice Chairman of the Panel. Their one-year terms began June 1. We again congratulate Bob and Gordon. ALKANOLAMINBS PANEL ELECTS OFFICERS The Alkanolamines Panel has elected Ed Bentley of Texaco Chemical Company to serve as Chairman and Stan Dombrowski of Dow Chemical USA to serve as Vice Chairman. Congratulations to both. We look forward to their leadership. NEW PROGRAMS SPECIALTY ACRYLATES AND METHACRYLATES Manufacturers and users of specialty acrylates and methacrylates have requested establishment of a Special Program at CMA. The Panel will address restrictions placed on new chemicals by EPA in the premanufacture notice review procedure under Section 5 of TSCA. EPA's concerns stem from a few rodent bioassays on chemicals that the Agency considers structurally related to the new acrylates and methacrylates. The restrictions include labeling requirements, limits on distribution and specific work practices. These restrictions are not mandated for the structurally related materials. The Program's member companies feel that the structural analogies are weak and that the restrictions are unwarranted. The Panel's major objectives are to obtain relief from the most restrictive provisions and to develop a better structureactivity framework for review of these chemicals. - 11 * Currently 14 companies have agreed to participate in the Program. Paul Nelson of Radcure Specialties will Chair the Panel. Harold Flegenheimer of Interchem, Inc. will serve as Vice-Chairman. If you wish to join the Panel. or want additional information. please call Dr. Elizabeth Moran at 202/887-1182. ALKYLPHENOLS AND ETHOXYLATES A group of manufacturers and users of alkylphenols and ethoxylates met recently and agreed to request a Special Program under CMA. The new panel will address anticipated regulatory agency activities under TSCA and the Clean Water Act. The Panel also will gener ate and evaluate information necessary to assess any environ mental or health effects. Dr. Jay Ansell of the GAF Corporation was elected Chairman of the Panel. Dr. James Mieure of the Monsanto Company was appointed chairman of the Environmental Risk Assessment Task Group and Dr. Isadore Morici of the Rohm and Haas Company was appointed Chairman of the Toxicology Research Task Group. Companies interested in joining the Program should con tact Henry Sauer (202/887-1189). RECENT RELEASES SPECIAL PROGRAMS COMMENTS Comments to the State of New Jersey on the HAZARDOUS SUBSTAN CES FACT SHEET ON BIS(2-ETHYLHEXYL) PHTHALATE (DEHP). (filed by the Phthalate Esters Panel, March 17, 1987) Comments to the U.S. HOUSE OF REPRESENTATIVES on DEPLETION OF BOR 007436 THE EARTH'S STRATOSPHERIC OZONE LAYER (filed by the Fluorocarbon Panel, March 20, 1987) Comments to OSHA on the DRAFT MDA ADVISORY COMMITTEE REPORT (filed by the Methylenedianiline Panel, April 1, 1987) Comments to the THE U.S. HOUSE OF REPRESENTATIVES on WORLD WIDE PRODUCTION OF CFC-113 (filed by the Fluorocarbon Panel, April 3, 1987) Comments to EPA on EPA'S EFFORTS TO TRANSFER PCB STORAGE AND DISPOSAL REGULATIONS FROM TSCA TO RCRA AUTHORITY (filed by the Polychlorinated Biphenyls Panel, April 28, 1987) Comments to OSHA on the REVISED DRAFT ADVISORY COMMITTEE REPORT (filed by the Methylenedianiline Panel, April 28, 1987) Comments to UNEP on the report of the AD HOC MEETING OF EXPERTS TO COMPARE MODEL PROJECTIONS OF OZONE LAYER MODIFICATION RELAT ING TO THE APPLICATION OF CONTROL STRATEGIES FOR CHLOROFLUOROCARBONS UNDER A PROTOCOL ON THE CONTROL OF CHLOROFLUOROCARBONS TO THE VIENNA CONVENTION FOR THE PROTECTION OF THE OZONE LAYER (filed by theFluorocarbon Panel, April 29, 1987) Comments to EPA on CMA BIOCIDES PROGRAM PANEL REQUEST TO MODIFY ANTIMICROBIAL DATA CALL-IN (filed by Biocides Panel, May 15, 1987) Comments to EPA PROPOSAL TO ADJUST QUANTITIES on EPA'S REPORTABLE (filed by the Polychlorin ated Biphenyls Panel, May 15, 1987) Comments to the SYRACUSE RESEARCH CORPORATION on DEVELOP MENT OF A TOXICOLOGICAL PROFILE FOR PCBs (filed by the Polychlorinated Biphenyls Panel, May 22, 1987) Comments to the U.S. SENATE on STRATOSPHERIC OZONE DEPLETION AND SUBSTITUTES FOR OZONE DEPLETING SUBSTANCES (filed by the Fluorocarbon Panel, May 27, 1987) Comments to EPA on the ROUTE OF ADMINISTRATION FOR 2-EH BIOASSAY TESTING REQUIREMENTS (filed by the 2-Ethylhexanol Panel, June 2, 1987) Comments to FDA on INFORMATION ON CRITICAL ISSUES TO EVALUATE THE CARCINOGENICITY OF BUTYLATED HYDROXYTOLUENE FOR HUMANS (filed by the BUtylated Hydroxytoluene Panel, June 8, 1987) FEDERAL REGISTER NOTICES POLYCHLORINATED BIPHENYLS SPILL CLEANUP POLICY; FINAL RULE (52 FR 10688, April 2, 1987) HEALTH AND SAFETY STANDARDS; OCCUPATIONAL EXPOSURE TO 2-METHOXYETHANOL, 2-ETHOXY- ETHANOL AND THEIR ACETATES (52 FR 10586, April 2, 1987) INERT INGREDIENTS IN PESTICIDE PRODUCTS; POLICY STATEMENT (52 FR 13305, April 22, 1987) PROPOSED RULE UNDER TSCA TO GATHER INFORMATION ON 36 CHEMI CALS USED AS INERT INGREDIENTS IN PESTICIDES (52 FR 18245, May 14, 1987) BOR 007437 CHEMICAL INFORMATION RULES; ADDI TION OF CHEMICALS (52 FR 18250, May 14, 1987) TESTING CONSENT AGREEMENT DEVELOPMENT FOR CHEMICAL SUBSTAN CES UNDER TSCA SECTION 4; SOLICI TATION FOR PUBLIC PARTICIPATION (52 FR 18738, May 19, 1987) CYCLOHEXANE; PROPOSED TEST STANDARDS AND REQUIREMENTS (52 FR 19096, May 20, 1987) CRESOLS; FINAL TEST STANDARDS AND REPORTING REQUIREMENTS (52 FR 19082, May 20, 1987) GUIDELINES FINAL RULE, "REVISION OF TSCA TEST GUIDELINES (FR 19056, May 20, 1987) MESITYL OXIDE; FINAL TEST STAN DARDS AND REPORTING REQUIREMENTS (52 FR 19088, May 20, 1987) SOLID WASTE CHEMICALS; PROPOSED TEST RULE (52 FR 20336, May 29, 1987) HYDROQUINONE; FINAL TEST STAN DARDS AND REPORTING REQUIREMENTS (52 FR 19865, May 28, 1987) FINAL REPORTS "Acute Toxicity Study of 2-Ethyl- hexanoic Acid in the Rat," (Ethylhexanoic Acid Panel, May 6, 1987) "A 21-day Gavage Study of 2-Ethylhexanol and Tris (2-Ethylhexyl) Trimellitate to Rats; Effects on the Liver and Liver Lipids," (2-Ethylhexanol Panel, June 26, 1987)