Document n64b3e3pnV3gkoq1oaEgoyM8

'ir ? 7- , *>;**V J, r ' U * c*K r -~r7- - - ^ r :... h - ; r i ... . " r' ' 1 < .' J` > > fv ' ;| if5 t ff ^ iI S l^ i ?.< -:..<>.*<<^ . - ' s ;-:..-;--1 ; !Xi- ':<.. .< ,'. -, w . * s ; ; 'h? : x < ,r ' sSSfs<Wigai ' \ i v ^ v -/ i0 $WM%mg0 Bx 'II SS I. | ig g j^ m r&m t. im m r ': ' t & r & f & Q S z s .............................,r ,, , .............................. - N o . D- 1 2 5 2 V2 Man u fact u r ed Dy Braw ne -Morse C o mpa ny MUSKEGON, MICHIGAN Ca s e s of TEL poisoning I. G. F a r b e n Ma n u fa c tu r i n g P la n t, Fro se -H arz Mountains, Germ an y X E 002082 2 y e a r s I n t h e ch a m b e r a t a l e a d i n a i r c o n c e n t r a t i o n o f . O75 m g. p e r c u b ic m e t e r h a s b e e n o u t o f t h e ch a m ber s i n c e t h e en d o f 19 52 To d a t e t h e p o s t e x p o s u r e r e s u l t s o n t h i s s u b j e c t i n d i c a t e t h a t h e h a s r e t u r n e d t o e s s e n t i a l l y th e same le a d e q u ilib r iu m , as ju d ged by u r in a r y e xcr e t io n r a t e and blood con cen tr a tion as e xis t e d b efor e exp osu re. The s e c o n d s u b j e c t , h r i s now in the cham ber on a sch ed u le I d e n t ic a l with the f i r s t s u b je c t . H owever, the ch am ber le a d i n a i r c o n c e n t r a t i o n i s now .15 0 mg. p a r c u b ic m e t e r , f r . f i r s t e n t e r e d the cham oer a t the above co n ce n t r a t io n P e b . l 6t h , 1953 H i s e x p o s u r e was d i s c o n t i n u e d fr o m f o b . 2 5 t h u n t i l Apr i l 1 7 t h , w h i l e we i n v e s t i g a t e d a s a m p l i n g a r t ! f a c t w i t h t h e e l e c t r o s t a t i c p r e c i p i t a t o r a t lo w s a m p li n g r a t e s . The p r e s e n t s t a t u s o f t l i i s i n v e s t i g a t i o n i s g i v e n i n m em oran d u m a t t a c h e d . The month exp osu re s in ce Ap r il 17t h to d ate has r e s u lt e d in r a is in g t h e s u b j e c t s l e a d b l o o d l e v e l t o a p p r o x i m a t e l y . 035 m g . / i O O g . a n d h i s u r i n a r y c o n c e n t r a t i o n t o a p p r o x i m a t e l y . 07 m g . / L . T h e s e valu es are s u b s t a n t ia lly h igh er than h is pre-exposure va lu es, and are ge n e r a lly in lin e with valu es expected* X'N r\ 0020825 n ?.4TH S 0 ? LFAD THKAhATIOH m iD Y A3 OF v AT 1 8 . 1 9 5 5 The f i r s t s u b je c t , Mr. who s p e n t a p p ro x im a te ly 7 hours par day, 5 days per week, fo r a pe rio d o f appro xim ately 2 ye a r s i n th e cham ber a t a le a d i n a i r c o n c e n tr a t i o n o f *0 75 stg. pe r cu bic m eter has been o u t o f the chamber s in c e th e end o f 1952* t r .. To-_date-Tfche--pea-fr expo ewao-HPetrulrta on t h i s s u b ja c ^ i n d i c a t e t h a t he h as re tu rn e d to e s s e n t i a l l y th e same l e a d e q u i li b r i u m , aa Ju dge d f * ' V-l '^ >3u .3*' +* </*.* < & */ &*!/ ** i & S * y] u r i n a r y e x c r e t i o n rarfee and b l a s d c o n c e n tr a t i o n h 6 Lfn r e--exp 'C^ a ? ^ ''*"""^ The s e c o n d s u b je c t , Mr* id now i n th e chamber on a s ch e du le i d e n t i c a l w ith ^ th e f i r s t s u b je c t . However, the chamber le a d l a a i r c o n ce n tra tio n i s now .15 $ g* per oubi m eter* Mr. Cre e c h f i r s t e n te r e d th e cham ber a t th e abo ve c o n c e n tr a t i o n Feb* l >th, 1955 H is e xpo s u re was d is c o n tin u e d from r e b . 2 5 th u n t i l A p r i l 17 t h , w h ile we I n v e s t i g a t e d a s am p lin g a r t i f a c t w ith th e e l e c t r o s t a t i c p r e c i p i t a t o r a t lo w s am p lin g r a t e s , lie p r e s e n t s t a t u s o f t h i s i n v e s t i g a t i o n i s g i v e n i n memorandum a tt a c h e d * The it . "4 m onth,Exposure s in c e Ap r il 17 th to d ate has r e s u lte d i n r a i s i n g : the s u b je c ts le a d blo o d l e v e l to a p p ro xim a te ly .0 55 m g./ lOOg. and h i s u r i n a r y c o n c e n tr a t i o n to a p p ro x im a te ly .0 7 a i g . / h . ^These v a lu e s a r e s u b s t a n t i a l l y h i g h e r th an iyafcijiaiies^^ , and are ge n e ra lly in lin e w ith valu es expsated* Kf 0020826 n T A?XT8 Qy T. -AD I u TTh L h TI OT T' H' BY' W 0 ? T AT l' The f i r s t s u b j e c t , who s p e n t a p p r o x i m a t e l y 7 hours p er d a y, 5 days per week, fo r a p er io d o f a p p r oxim a tely 2 y e a r s i n t h e ch a m b er a t a l e a d i n a i r co n ce n t r a fe lo n o f .0 75 nig. p e r cu b ic m et er h a s been o u t o f th e cham ber s in c e th e end o f 15 5 2 . To d a t e t h e p o s t e x p o s u r e r e s u l t s o n t h i s s u b j e c t i n d i c a t e t h a t h e h as r e t u r n e d to e s s e n t i a l l y th e same lo a d e q u ilib r iu m , a s ju d ged by u r in a r y e xcr e t io n r a t e and b lood co n ce n t r a t io n as e x is t e d b efor e exp osu re. ' The s e c o n d s u b j e c t , i s now i n th e ch am ber on a sch ed u le id e n t ic a l w it h the f i r s t s u b je c t . H owever, the cham ber le a d i n a i r co n ce n t r a t io n , i s now .15 0 mg. p a r c u b ic m e t e r . . r . f i r s t e n t e r e d th e cham ber a t the above co n ce n t r a t io n T e h . l 6t h , 1955 H i s e x p o s u r e wa s d i s c o n t i n u e d fr o m f e b . 2 5 t h u n t i l A p r i l 1 7 t h , w h i l e we i n v e s t i g a t e d a s a m p l i n g a r t i f a c t wit h , t h e e l e c t r o s t a t i c p r e c i p i t a t o r a t lo w s a m p lin g r a t e s . The p r e s e n t s t a t u s o f t h i s i n v e s t i g a t i o n i s g i v e n i n memorandum, a t t a c h e d . The month exp osu re s in ce Ap r il 17t h to d a te h as r e s u lt e d in r a is in g t h e s u b j e c t s l e a d b l o o d l e v e l t o a p p r o x i m a t e l y *0 55 m g./ lQ O g. an d h is u r in a r y co n ce n t r a t io n to a p p r o xim a t e ly .0 7 a g ./ L . These valu es are s u b s t a n t ia lly h igh er th an h is p re-exp osu re valu es and are g e n e r a lly in lin o -with va lu es e xp e ct e d . K * 002082? The f i r s t s u b j e c t , l i r who s p e n t a p p r o x i m a t e l y 7 h ou rs p er d a y, $ days p er week, for a p e r io d o f a p p r o xim a t ely 2 ye a r s i n t h e cham ber a t a le a d i n a i r c o n c e n t r a t io n o f .0 7$ mg. p e r c u b ic m e t e r h a s b e en o u t o f t h e ch am ber s in c e t h e en d o f 19 5 2 . To d a t e t h e p o s t e x p o s u r e r e s u l t s o n t h i s s u b j e c t I n d i c a t e t h a t h e h as r e t u r n e d to e s s e n t i a l l y th e same le a d e q u ilib r iu m , as ju d ged by u r in a r y e xcr e t io n r a t e and blood con cen tr a tio n as e xis t e d b efor e exp osu re. The s e co n d s u b j e c t , h r . la now in th e ch am ber on a sch ed u le id e n t i c a l w it h th e f i r s t s u b je c t . H owever, the ch a m b e r l e a d I n a i r c o n c e n t r a t i o n i s n ow *1$0 m g. p e r c u b i c m o t o r . : :r . 1r t e n t e r e d t h e c h a m b e r a t t h e a b o v e c o n c e n t r a t i o n F e b . l o t h , 19>3 H i a e x p o s u r e wa s d i s c o n t i n u e d f r o m F o b . . 25t h 'u n t i l A p r i l 17 t h * w h i l e we I n v e s t i g a t e d a s a m p l i n g a r t i f a c t w i t h t h e e l e c t r o s t a t i c p r e c i p i t a t o r a t low s a m p lin g r a t e s * The p r e s e n t s t a t u s o f t h i s I n v e s t i g a t i o n . i s g i v e n i n m em orandum a t t a c h e d . The month exp osu r e s in ce Ap r il 17t h to d a t e h as r e s u lt e d in r a is in g t h e s u b j e c t 's l e a d b l o o d l e v e l t o a p p r o x i m a t e l y - . 0$$ m g . / l G G g . a n d h i s u r i n a r y c o n c e n t r a t i o n t o a p p r o x i m a t e l y . 0 7 s &g./ L. Th e s e valu es are s u b s t a n t ia lly h igh er th an h is p re-exp osu re va lu e s , and a r e g e n e r a lly i n lin e with, va lu es o xp a a t e d . 0020828