Document mvgQ8X82ZOv5dOVwmOoMjNyg

Kxi:cimvj:'Grr:ci:s twkntt two i.a> r roi. ri ::tii s iiii.nr .vt:w Yimi:. x. y. January 12, 1940. Hr. Suroncr Simpson, President, Raybe s tos-ilanha t tan, Inc., Bridgeport, Conn. Dear Mr. Sinason: \v''n 'Ms*-- Sap:Hone nting Dr.. Gar cner* S lit test r eport l his c>:pc riir.ents with a sees to s cius t, 1 urn or. closing rewith copy of a let ter cpnta ir.ing the comae nts of . A. J. Lanza cn the results tints far a ctaiu od. You will not o that in his cpin ion it would r well V.rorth v.hil c to have Dr. uii. acr pursue iis :pe ri men tal vvori: to i ts cor.ciu sion. Sincerely, YB:y Enc. I Vandiver Brown, General Attorney. t 1t V J -4 (d) Anthophvlllte -- stiff, straight fibres - atypical asbeatoale ' bodies forma slowly but no localization or fibrosis in lungs.'' (e) Aaoslts - Ditto. (f) Aciohlbole - Ditto. (f) Treaollta - Ditto but very few asbestoele bodies - Observation* being oontlnued. . V Control Mineral . (a) Granular Sernentlne of ease ohemioal oonpoeition aa ohryeotile la inert caualng no flbroala in lunga or other organa, ut V* - attraota iron fron the lunga but of oourae, no "bodies1 develop. (b) Olaag Voolta aynthetlo silicate) fibrae are not inhalabla fron ; air-borne suapenalona, apparently beeauaa of their atiffneaa (the dlaneter is not responsible ae aone used vara laaa than'.'' 1 alcron thick) On lnjeotion into the lunga, they do not y localize in the air .tubes but are widely aoattered. They oauae no flbrool8. After 3 or 4 oontha in oontaot with lung fluid, * a few glass flbrea take up iron but remain smooth. They newer show the evollen ends and lateral projections of the true -* > asbeat06i8 bodies. (c) Bruclte of interest because it la a fibrous mineral praotically free of allies (o.9$). Cryatallographioally the arrangement of its Ho and OH groups in eaoh unit oell ia similar to that in chryeotlle. The sample used also oontalned about 16> iron, pro bably from contaminating magnetite. The flbrea are etiff and needle like. ObaervAlona not yet completed but after 2 months in the lungs, typlpal aabeetoala bodies develop but there la aa yet no flbroala. *he fibre are scattered through the lung lnate of being, localized inside the terminal air tubes and tissue reactlon'.occura around, instead of within the tubes. # VI Chernies! Composition jin Relation to Irritation (a) Nothing in the following chemical compositions can be cor related with variations in capacity to provoke tissue reaction. (See Table Next-Rage) :> v-tir.* :? ChP7- Croold- **w**w- .~ otlle ollte * tahYl3.ltn tj Q? P^ Q: Pa 0 37.43* 2.35* 54.99* 67. Aa*'*--4** *46.23* 55 :04*;>-66.20* 0.90*'<^*-? 16.27*_____ &1*.' 61* *. *4*'.06*' V.j*-.-*'3**.08* - 7..21**.*. 6.7e*- -*^iV$/^3. *% 0__________ 4.29* Q) 7 r 33.83* 6 Q^r.:; ' 9.36*~%r*S> 0.36* 1.02*-' 0>..2255* 11..0099** ii^:6V9*^': Q.M*. 0.66*'0.4 C._0________ 0.05* 0.79* 0.44* 2.01* 12.22* ` * 4,45* 0.40* r--i Mi. HuO KvO 38.77*' -0.2$ 0.08 L*as410S* 4.30 12.25* 6.92 0.57 0.02 29.64* 0.52 0.15 0.62 6.29* -91??. 0.10 0.66 23.29* 20.`62*'.63.99*' '*.=* . * 0.40 6.78 a. 0.91 *: \*v rt.19 A.OQ -a i.c. - fr-'/ 0.32 - 0.34, 0_ .5_3_ ****i* -a '>105* 14.92 (b) 2.56 2.42 1.51 8.69* 2.78 r- - .';,* *-*. .v ' Acid treatment.of ohrysotlle fibress^;\ -L. 1 One hour in dilute or oonoentrated BCL does not altar ap--*. pearanoe of fibre but aftor suoh treataent it rapidly-dis solves and disappears on lnjeoting into living tissues %- - , ,*r ii Treataent with C02 bubbled through water* or lung juice \* suspensions of ohrysotlle fibres aauaes partial solution with liberation of silloa and magnesia. (c) Colloidal alluaina does not neutralize the'effeota of asbestos as it does o.uartz. On injecting ohrysotlle suspended in alunlnua hydrate solution, fibrosis and asbestos bodies dev elop at the usual rate, it reaalne to deaonstrate whether the fibres*beooae ooated with a layer of alunlnua nonohydrate as . has been proved in the case of quartz, -if they have, the ooat. does not affect their oapaoity to irritate tissue. VII Physical Properties In Relation to Irritation of Lung Tissue (a) Length ,a Plbre Short ohrysotlle fibres under 3 microns are praotlcally inert. 20 to 50 nloron fibres cause typical fibrosis. The effects of longer ones oould not be tested for technical reasons. - (b) Crushing completely destroys the fibrous structure of " - chryeotlle. Ylth lose of etruoture, all oapacity to irritate disappears.