Document mqwJX2Qb3Q8JLBNq2RgnZpO8O

BUREAU OF s t a t e : s e r DEP ARTM EN T OF H EALTH , ED U CATI O N , AND W ELFARE PUBLIC H E ALTH SERVICE W A S H I N G T O N 15 , D. C. Refer to : D r. Robert A. Kehoe D irector, Ketterin g Lab o rato ry College of M edicin e U n iversity of Cin cin n ati C in cin n ati 19, O h io FEB 2 9 1960 D ear D r. Keh oe: M em b ers of our st aff h ave d isc u sse d the p rop osed su b stitu tion of tetram eth y l lead (TM L) for tetraeth y l lead (T EL) in ce r t ain ga so lin e s to be m ar k e t e d by a m a jo r p etr oleu m com pan y. A s you know , the P u b lic H ealth Ser v ice h as no le gal au th orization to r e gu lat e th e u se of su ch su b st an ce s in ga so lin e . We b e lie v e th at th e d e cisio n to u se TM L a s a su b stitu te for T E L is on e w h ich sh ou ld b e m ad e by th e co m p an ie s con cer n e d a ft e r due co n sid e r at io n of th e h a z a r d s w h ich m ay r e su lt to th e ge n e r al p u b lic an d to w o r k e r s en gaged in the m an u factu re of TM L and it s blen din g and a lso th ose en gaged in th e w h olesale an d r e t a il m ar k et in g of t h e se g a so lin e s. We a lso b e lie v e th at r e p r e se n t a t iv e s of th e co m p an ie s sh ou ld d isc u ss th is m at te r w ith th e Stat e h ealth au t h o r it ie s in th e St a t e s con cer n ed . If the d ecision is m ade to u se TM L as a gasolin e ad d itive, w e w ould su gge st th at th e com p an ies con du ct st u d ie s th at w ould d em on strate its accep tab ility from th e pu blic h ealth view poin t. Sh ou ld it d e v e lo p t h at T M L can n o t b e m a n u fa c t u r e d an d u se d in gaso lin e w ith out un due r isk to th e w o r k e r s or to th e p u b lic, the P u b lic H ealth Se r v ic e w ould reco m m en d th at it s u se be d iscon tin u ed . In th e m an u factu re and blen din g of TM L, it is a lso su ggested th at the sam e h ygien ic stan d ar d s ap p licab le to T E L be u se d . Sh ou ld th e c o m p a n ie s c o n c e r n e d p r o c e e d w ith th e su b st it u t io n of TM L for T EL, we su ggest th at liaiso n be estab lish ed betw een the com p an ies an d th e P u b lic H ealth Se r v ic e w ith th e u n d erstan d in g th at the P u b lic H ealth Ser v ice w ill h ave a c c e ss to all clin ical, en viron m en tal and oth er pertin en t d ata relatin g to any stu d ies u n dertak en . k 0009268 D r. Robert A. Keh oe 2- - We also su ggest th at the com p an ies p resen t to the P u blic H ealth Se r v ice one y ear aft e r in itiatin g th e su b stitu tion a r e p o r t on th e im p act of TM L on the con tam in ation of th e at m o sp h e r e in a m a jo r m etropolitan cen ter a s w ell a s clin ical an d en viron m en tal d ata d em on stratin g the safe ty of co n tr o ls in the m an u factu r e, u se and h an dlin g of TM L an d of gaso lin e s con tain in g th is com poun d. Sin cerely y ou rs, / '- c y/ ' 2 t L; A ssist a n t Su rgeon G en er al Ch ief, Bu r e au of State Se r v ic e s KE 0009263