Document mqaO35jmzRe4YVQd64nBgZxnZ

rrYLAMlNE production ano physiological measurements in subjects ingesting sodium cyclamate. ^eld and A. A. B. Swan. Tox. Appl. Pharmacol. 18i 535-541, March 1971 ejects capable of metabolizing cyclamate to cyclohexylamine ingested 5 g. sodium cyclamate for 7 or 8 days. The conversion to cyclohexylamine and consequent absorption was followed by asurement of the amine in consecutive 24-hr urine samples. The maximum daily excretion of ea 1)14 famine in 5 subjects in a total of 69 volunteers ranged from 0.1 to 0.9S of the daily cycllamheate intake. It was concluded that no pharmacologically active concentrations of cyclohexylamine eye reached in the tissues of these subjects capable of metabolizing cyclamate after daily ingestion ere jarge amounts of cyclamate for a week or more. --Cond. from Authors' abst. of INDUSTRIAL DUSTS' COMPLICATIONS OF ASBESTOS EXPOSURE. 0. R. Gracey, et al. Cheat 59: 77-81, Jan. 1971 Aie patient described in this article developed a malignant pleural mesothelioma more than 25 years fallowing brief employment In an asbestos processing plant. The authors discuss the relationship between asbestos exposure and neoplasm, the Intriguing subject of co-carcinogenesis and the potential hazard to urban dwellers from the increasing industrial usage of asbestos. Pleural and parenchymal fibrosis are conmon radiologic features of pulmonary asbestosls but are by no means unique to this disorder. Similarly, pulmonary function abnormalities may Include the entire gamut of ahyslologic changes, depending upon the stage of the disease, complications and associated pathologic lesions. Unfortunately, no treatment is possible for this type of mesothelioma other than temporary palliation of the pleural effusion. --Cond. from text MORTALITY IN THE CHRYSOTILE ASBESTOS MINES AND MILLS OF QUEBEC. J. C. McDonald, et al. Aroh. Environ. udth 2it: T77-fi85,"June 1971 Of 11.788 persons bom between 1891 and 1920 employed in the Quebec asbestos mining Industry, 88.4X Here traced. Of these 2,457 (23.6%) had died. Exposure indexes for each worker were calculated from job dust levels and duration of employment. The overall mortality was lower than expected for the population of Quebec but in the highest dust category, comprising 51 of the cohort, the age- standardized rate was 20% higher than in the other groups. Respiratory, cardiovascular, and malignant diseases In equal proportions accounted for the excess. There were 101 deaths from respiratory cancer including three from malignant mesothelioma, an estimated excess of about 15 deaths. The difference in rates for respiratory cancer between those maximally and minimally exposed was fivefold and, though perhaps exaggerated, was apparently determined by accumulated dust exposure and duration of employment. --Authors' abst. tutor's Sote: In view of questions raised in the past concerning the findings of the study conducted oy Ihr in 1957, it is extremely gratifying to note that the above study, which was more extensive and involved a longer period of observation, effectively confirms the conclusions reached in our study regarding pulmonary malignancy among chrysotile miners in Quebec. --D.C.B. PHYSICAL ASPECTS OF THE ENVIRONMENT WSE HAZARD METER. J. H. Botsford. Am. Ind. Hyg. Assn. J. 32: 92-95, Feb. 1971 A noise hazard meter has been designed to evaluate a noisy environment in terms of the anticipated emporary threshold shift (TTS). The instrument presents an electrical analog of the component the TTS. The noise hazard meter was tested with a group of normal individuals in a noisy -nviromrent. Encouraging results are reported and further studies are planned. --Author's abst. 19.