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- Gener Offices m SCianoesr son GEHQ- 0704 -- 00573 3M Certified Mail "aid oo _AR22%- DEoPcAumEeasntt-PRroocoesmsi6n4g2C8eAntttenr: Section 8() UOfSfiEcPe Aof Pollution Prevention and Toxics W1a2s0h0iPnegntnosnylDvCani2a04A6v0e-n0u0e01NW RE: TDoScCkAet8N(oE.) S$EUHPQP-L11E8M0E-3N7T3AL SUBMISSION: u /800 Dear Sirs: 3wiMthhapesrrlelcueoirvoeodctparneelsiumlifnoanryy! rfelsuuolrtisdefo(aPrO9S0F-,dCayASin#ha3l0at7i-o3n5s7t)udiyndiincarattisngcotnhdtuctthedtest substance metabolizes to perfluorooctane sulfonate (PFOS, CAS# 2795-39-3). "fTihvee sfteumdaylewsaasncdonfidvuecmtaeldebsypHerungtrionupg,downerLeifeexSpcoiseendcetso,PLOidS.FSvparpaogrueatD0a,w3l0,ey10r0at,s,and 3we0e0ksp.pmAnbiymnaolssewfoerrseixevahlouuartsepdearfdeary,a ffiovuerd-awyesekperrecwoeveekr,y fpoerrtihoidrtfeoelnlocwoinntgintuhoeus thirteen week exposure. AHyndarloylsyissiosfpsreordaucstamopflePsS,Fl.ivearss,wealnld ausripneerfflruoomrotohcetsaenaotatsei(dePnFtOiAfi)e,d aPFmOanSu,ftahceturing rmeasliedsu,alPoFfOPSOSaFn.d PPFOOSAFciotnsceelfnwtarastinoontsiidnecnriefaiseedd iinn tphreopseorrat,ioinvtro,PaOnSdFureinxep.osIunre cinocnrceeansterdatiinonprloepvoerltiinonalltobiPoOloSgFiceaxlpmoasturriceesc.oncIenntfreamtailoens,lePvFelOiSn calolncmeantrtircaetsi.onsPFOA whoawsedveetre,ctbeedcaiun speroPpForOtAionistroapPiOdlSyFcleixmpionsautreed cionncfeenmtaraltiraotns icnotmhpeaurreidnetoofmfaelmealraetss;, PinFsOeAruwmaasnodnlliyvedretseacmtpalbelse afbroovmeftehmealleimsitinotfhdeehtiegchteisotn (esxeprousmu)reorcobnaccekngtrraotuinodn(gIrvoeurp.) AssubsctonasnicsetemnettawbiotlhizpersevtioouPsFlOyS.sub3miMttdeodesstundoitesb,el3ieMvebetlhiaetvtehsetPhaOtStFhetePstOSsuFbstetsatnce rmaentgaeboelxipzeecstteodPbFaOseAd.onRatthheerl,evtehleoPfFPOFAOAcocnocennttarmaitniaotnisonion fmtahlee reasttsseruabswtearnecei antdhe =2 f2o9n8 L oubusm z . ME ; Imt 1 re the relationshipof exposure concentrationof concentrations (Hinderlitetr al. 2004)". PFOA to steady-state serum PFOA rAedsdpiitriaotnoarly fiimintdaitnigosno,fatnhdissostmuedycliinnicclauldechbeomdiystwreyiegfhftecetfsfescitmsi,llairvetro htyhpoesretorbospehry,ved after PFOS and/or was not observed; lPiFveOrAceltlrehaitsmteonpta,thaoslroegpiocretfefdecptrsevwieoruesloybsteorEvPeAd.at A no-effect 30 ppm. level PPFOOSSE awnadsruesleadteadsparnodiuncttesr.me3diMatneoglaosnigneranmainsuoflaatcetdurinedsusPtOrSiaFl.process to produce: A final report will be forwarded to EPA when received. Please contact John Butenhoff provide additional information. (651-733-1962)ifyou haveany questions orif we can Sincerely, Larry R. #Gbel, MD MPH Staff Vice President and Medical Director b! eHtiwnednerrlepieea,teP.d Min.h,alDaetLioonmmeexp,oMs.ureP.saannddpJleapssomna,PG.FOWA. c(o2n0c0e4n).traPteirofnluinortohoecrtaat.noiTcoxaiccdo:lorgeilcaatlionship Sciences, 78 (Supplement Number 1.8), abstract no. 1918.