Document mpdR4dnx0Gjz9Bep72emBxJK4

Oct 02 02 03:29p : Ralph Cooper 519 se1-s138 pz AR 2' 26 _ 1198 +"<3@8:x" NZ tron NUaNtIioTnEaDl HSeTaAltThEaSndENEnVvIiRroOnNmMenEtNalTEAfLfePctRsORTeEsCeaTrIcOhNLaAbGorEaNtoCrYy Reproductive Toxicology Division Research Triangle Park, NC 27711 MEMORANDUM October 2, 2002 SUBJECT: Control vs. PFOA (30 mg/kg) and vaginal cycling, FROM: Ralph L. Cooper, P.O Z- elleZrBrgunto' cz-om Endocrinology Branch (MD-72) RTD, NHEERL, ORD = = 8 z a2 = TO: RJeAnDn,ifeOrPPSeTe,d,OPPTS = fTheimsaliessintrreeastpeodnwsiethtoAyPoFuOquvse.stcioonntrcolo.nceInrntihnegF1thegevnaegriantailocnyacnliemsadliss,plthaeyevdagbiynaFl1 smear patter present in the control and "high dose" APFO (30 mg/kg) dosed groups were evaluated for cyclicity during a 21 day observation period prior to mating. There were pcthyeicrrlityeosdasn(iRo)mf.aplursnoelpvoenergngerdcoyudcpii.iensgtTrh(uIseR)(cdy(ecdfleiefnsiendweedarsaes4e-bv6raidlefauayptederidieosadtssruhwsaitvphienrigiroredeisgt)uhleearrxtrpeeagntudeleradnr)e4-so5trrudsay (defined as 3 or 4 2 &-greater days days of cornified of leukocytes) or psemresairsst)e,ntpoessstirbulsy(pPsEe,uddeofpirneegdnaasnt5,.0(rPgSrPo,atdoerfidnaeyds doiffcfoerrneinftiiend asnmyeaorfst)h.e pTahreasmeetdeartsa maeraessuurmemda.rized in table 1. The two groups were not Table 1 summarized the data ow Ovarian Pattern regTuylapreity Control APFO (3omglkg) 3 = RiR. 3daTyotEasltrus 18 120 20 9: - =Zz .~ PSP 4 ndaoypdaitesetrrus. 2 1 52 22 PE 1 1 ~ CONTAIN NO CF! ! UST Ue UZ UIiZIP Ralph Cooper 919 541-5130 ra . cgForinentaartloel,ratinnhietmhanelusdmobasenerddotvfhsecycococlncetusrroilrneawnnhciiemocafhlsa.thtiHswoosw-medevaaeyrr,epsaattsrtuetsrhnipsaistptanetorttnerudnniudcsaaunaplpb,eaaorbtao cbmeed in concluded that the vaginal cycles in the dosed rats was unaffected by Thus, APFO. 1 & 3 &