Document mpJObdbkYDN7EYvQB3DQdy9ZQ

DATE: TIME: PLACE: CHEMICAL MANUFACTURERS ASSOCIATION % Vinyl Chloride Health Committee C__< M Tentative Agenda October 31,1995 10:30 a.m. CMA Offices 2501 M Street, NW Washington, D.C. 20037 C ''4- \ i ct \ tA-\& . / \ U- V. :-C -- 10 AM 1.0 Discussion of Brain Cancer Case Control Study 1.1 Carlo Tamburo (University of Louisville) Proposal 1.2 Cost 2.0 Status Report on CMA Vinyl Chloride Epidemiology Study Update 2.1 Applied Epidemiology, Inc. -- Efforts To Date .X f-'__J: 2.2 ENSR -- Contracted Obligations and Problems 2.3 CMA -- Efforts and Actions To Date 2.4 Impact on AEI Contract -- Timetable and Financial 2.5 Decision on Extending the Update Through 1994 2.6 Additional Funding Needs 3.0 Discussion of ATSDR/EPA Testing Requirements 3.1 Developmental/Reproductive Effects Study Protocol ' 3.2 Neurotoxicity Testing Needs 3.3 Review of Memorandum of Understanding Between ATSDR and HSIA ' > ^ 3.4 Identification of Laboratories for Requesting Bids for Developmental/ j 1 Reproductive Effects Study X- ^ ^- * 3.5 Expansion of the Developmental/Reproductive Effects Study Prptocol to TInncHluiid^eo \MAonl1eacnutllaarr RReosceoaarrcrhh nonn \V7iinnuyll PChhllnorriiHdee - ^^ ^OJMA Mr------ 3.6 Cost Estimates 3.6.1 Developmental/Reproductive Effects Testing 6 c 3.6.2 Neurotoxicity Testing 3.6.3 Molecular Research WiV-, v- c\jsr , A w 3.6.4 Legal 1 ' 3.6.5 Contingency I/O 4.0 Discussion of Vinyl Chloride Risk Assessments 4.1 U.S. EPA 4.2 CalEPA -- No -'aMcMataM 4.3 Richard Reitz PB-PK Manuscript 5.0 Update on Vinyl Chloride Litigation c ka BFG 00103 AA 6.0 Discussion of Financial Statement 7.0 Development of 1996 Budget 7.1 ATSDR/EPA Testing Requirements 7.2 Epidemiology Study Update 7.3 Brain Cancer Case Control Study 7.4 Risk Assessment Activities 7.5 Administration LIC<P \^o lc A' 8.0 Set Date for the Next Meeting and/or Conference Call 0 i ^o 1C cAO Subject to approval Wuo ---- Hasmukh C. Shah, Ph.D Manager, Vinyl Chloride Health Committee BFG 00104 CHEMICAL MANUFACTURERS ASSOCIATION October 12,1995 Dear Vinyl Chloride Health Committee Members: The following items are enclosed: 1. comments prepared by Jonathan Ramlow on the draft protocol for Update of Mortality Among Vinyl Chloride Workers. These comments incorporate comments provided by Mark Gruenwald of Borden. No comments on the epidemiology study protocol have been received from any other member companies. Please review the enclosed comments and let me know if you have additional comments. I plan to send our final comments to Ken Mundt by October 20; and, 2. a revised protocol for the combined developmental/reproductive effects study. The revised protocol incorporates the ATSDR peer reviewer comments to the extent appropriate. Bill Breslin's response to the reviewer's comments also is included with the protocol. I have included ATSDR peer reviewer comments for your ready reference. Please call me with your comments on the revised protocol by October 19. I plan to send the protocol to the ATSDR on October 20. Dr. Breslin estimates the study cost at $650,000. Please call me at (202) 887-1192 if you need additional information. I am looking forward to seeing you on October 31. I will send you an agenda and other information for the meeting in the near future. Sincerely, Enclosures Hasmukh Shah Manager, Vinyl Chloride Health Committee 2501 M Street, NW, Washington, DC 20037 Telephone 202-S57-11CO rax 202-387-1237 BFG 00105 Responsible Care A Public Commitment