Document mmw5yyGq2X2w45aQ0ODBn9Gdb

CHEMICAL MANUFACTURERS ASSOCIATION July 10, 1986 ^ S*)c<L> YK*4<aA*- TO: FROM: Health and Safety Contacts of CMA Member Companies Nancy G. Doerrer ! Manager, Health, Safety and Chemical Regulations RECE SUBJECT: IARC's Classification of Potential Chemical Carcinogens ppjx - - - The Chemical Manufacturers Association has been invited to nominate an observer to participate in two upcoming meetings of the International Agency for Research on Cancer (IARC). With the promulgation of the OSHA Hazard Communication Standard, these meetings have increased significance for the chemical industry in its duty to warn against potential human carcinogens. You are being asked to review a list of chemicals, to Identify those sub stances of interest to your company, and to contact CMA by July 28, 1986, with nominations of company experts for proper chemical-specific representa tion of your scientific views. BACKGROUND A Working Group of experts chosen by IARC will meet in Lyon, France, from December 2-9, 1986, to assess the activity of approximately 200 chemi cals and complex mixtures in short-term tests. At a second meeting, to be held in Lyon from March 10-17, 1986, the degrees of evidence for carcino genicity in humans and experimental animals will be assessed for these chemicals and exposures. An overall evaluation of carcinogenic risk to humans will then be made based on experimental and epidemiological data. The list of chemicals/exposures is attached for your review. These substances have previously been evaluated by IARC in volumes 1-41 of the Monographs, but are under a second review because of the existence of new data. INDUSTRY PARTICIPATION The CMA Health and Safety Committee has established an IARC Work Group to organize industry participation in these two important meetings. The number of chemicals and short time period for assessment of this list has dictated a method of action that requires full CMA member company participa tion. Since a single CMA observer will be expected to have technical knowl- BOR 007566 Formerly Manufacturing Chemists Association--Serving the Chemical Industry Since 1872. 2501 M Street. NW Washington. DC 20037 Telephone 202/807-1100 Telex.89617 (CMA WSH) CMA Health and Safety Contacts July 10, 1986 Page 2 edge of each of the chemicals to be considered at the Monograph meetings, the CMA IARC Work Group has constructed a tentative scheme to prepare the ob server. During the month of July 1986, the CMA IARC Work Group requests that you identify all chemicals on the attached list that your company manufactures, produces, or that present a specific concern. Next, you should identify company expert(s), e.g. toxicologists, pathologists, or health specialists, who will be asked in the upcoming months to collect and evaluate all avail able published and unpublished scientific data, with special emphasis on short-term test data and carcinogenicity information. A classification for carcinogenicity on each chemical will made bjr your expert(s) using the IARC system. (IARC uses the classifications 1, 2a, 2b and 3 to evaluate potential chemical carcinogens. This system is discussed and described in the Preamble to the IARC Monographs.) CMA recognizes that there may be significant overlap in company inter ests in a given chemical. When we receive your list of chemicals and names of company experts, we will initiate joint discussions with you and other member companies who have expressed the same interest to equitably distribute the task of literature searching and carcinogen evaluation. Additionally, the work load for this project will be divided into two phases: 1) collec tion and evaluation of data on short-term tests in preparation for the December 1986 IARC meeting; and 2) collection and evaluation of data leading to carcinogen classifications in preparation for the March 1987 meeting. More specific instructions, recommendations, and a time schedule for comple tion of this project will be made available when you submit written confirma tion of your participation in the process. IARC issues draft working papers 4-6 weeks in advance of the Monograph meetings. This short review period is inadequate to evaluate chemicals of concern to industry, and does not provide the time necessary to train an Industry observer. Our proactive efforts to evaluate chemicals for carcino genicity, as described above, will thus provide us with a timely and accurate~ comparison of proposed industry/IARC classifications. We will have a full month to identify those chemicals likely to produce debate or controversy, and can prepare the CMA observer for the discussions. The CMA observer will not have a vote at the upcoming Monograph meet ings, but will have the opportunity to contribute to discussions concerning the scientific evidence for classifying chemicals as carcinogens. The nomination of this observer will consist of careful selection from a list of names generated by representatives of CMA member companies. The CMA IARC Work Group encourages you to suggest potential nominees in the coming months, CMA will provide the administrative assistance in collecting member company assessments on the 200 chemicals/exposures, nominating an industry observer to attend the meetings, and training the observer In communicating chemical-specific issues at the Monograph meetings. BOR 007567 CMA Health and Safety Contacts July 10, 1986 Page 3 In conclusion, CMA asks that you assist the Industry In providing a rational, scientific evaluation of carcinogenicity for chemicals under IARC review. Please make the appropriate identifications specified below, fill out the attached form, and return to CMA no later than July 28, 1986: o Identify chemicals/exposures on the attached list that are of specific concern to your company. o Identify company expert(s) to assess the health effects literature and to evaluate the carcinogenic data on chemicals of concern to your company. A second notice will be issued in early August to solicit additional participation from CMA member companies on a chemical-specific basis. Your prompt attention will facilitate the organization and administration of this project. Nancy G. Doerrer of CMA's Health, Safety and Chemical Regulations Division can be reached at 202/887-1282 with your responses, questions, and comments. Attachments 07S68 CHEMICAL MANUFACTURERS ASSOCIATION INDUSTRY PARTICIPATION IN IARC'S CLASSIFICATION OF POTENTIAL CHEMICAL CARCINOGENS RETURN TO: RETURN BY: Nancy G. Doerrer Chemical Manufacturers Association 2501 M Street, NW Washington, D.C. 20037 (202/887-1282) July 28, 1986 CHEMICALS/EXPOSURES COMPANY EXPERT(S) TELEPHONE NUMBER NAME COMPANY NAME ADDRESS TELEPHONE NUMBER Signed BOR 007569 IARC MONOGRAPHS ON THE EVALUATION OF THE CARCINOGENIC RISK OF CHEMICALS TO HUMANS: CHEMICALS AND INDUSTRIAL PROCESSES ASSOCIATED WITH CANCER IN HUMANS: UPDATING OF SUPPLEMENT 4 (PART I A PART U) exposure TENTATIVE LIST OF SUBSTANCES AND EXPOSURES TO BE CONSIDERED (At IARC Monograph Meetings December 2-9, 1986, and March 10-17, 1987) Exposure Acetaldehyde Acrolein Acrylonitrile Actinomycin D Adrianycin Aflatoxins Aldrin Aluminium production 4-Amincbiphenyl Amitrole Anaesthetics, volatile Analgesic mixtures ccxitaining phenacetin Fhenacetin Aniline (and its hydrochloride) Arsenic and arsenic expounds Asbestos Attapulgite Auramine, mnufacture of Auramine Azathicprine Bmaene Benzidine Benzidine-based dyes: Direct Black 38 Direct Blue 6 Direct Brown 95 Berylliixn and beryllium g.mp ninds Betel quid with and without tobacao (chewing) Betel leaf Areca nut H.N'-Bi* (2-chlaroethyl)-2-naphthyl" Seine (Qilamaphazine) Bischloroethyl nitroeourea (BQiU) Bis(chloramethyl)ether and technicalgrade chlorcmethyl methyl ether Bitunens Bleomycins Boot and shoe mnufacture and repair fracken fern 1,3-Butadiene 1,4-Butanediol dimethanesulphanate (Myleran) Cadmium and cadmium compands Carbon blacks Carbon tetrachloride Carpentry and joinery Cherotherapy for lynphomas: M3PP, etc. 0 BOR 007570 Chlorambucil Qiloraspheniaol Qilordane/Heptadilor JC o m Oilorinatad toluenes, production of: Benzol chloride Banzotrichloride Benzoyl chloride Benzyl chloride l-(2-Qiloroethyl )-3-cyclchexyl-lnitrosourea (COW) Chloroform Chlarqphenols 2,4-Dichlarophenol Bentachlarcphenol 2,3,4,6-TetrachlorophenoI 2.4.5-/Prichlarophenol 2.4.6-Trichlorophenol Qxloroprene Cholesterol Qironivan and dircmium compounds ortho-Chrysoidine Cisplatin Clofibrate Cbal gasification Coal-tar pitches Coal-tars Coke production Creosotes Cyclamates Cyclophosphamide Dacarbazine Depecne DOT Diazepam 1 * 2-Dibrooo-3-chlorcpropane egtho-Pichlorobenzene and para-Oichlorobenzene 3,3* -Dichlorobenzidine DidHorooethane 1.3- Dichlarcpropene Dieldrin Diethyl sulphate 3,3'-Dinethoxybenzidine (ortho- Dianisidine) Diaethylcarbamnyl chloride Dimethyl sulphate 1.4- Pioxane Epichlorohydrin Erionite Ethylene dib' snide Ethylene oxide Ethylene thiourea Fluorides (inorganic, in drinking- water) 5-Fluorauracil Formaldehyde Furniture and cabinet making Haeomtite mining, underground (with exposures to radon) tfeematite (iron oxide) Hexachlorobenzene Hexachlorocyclchexane Hydralazine Hydrazine Iren and steal founding BOR 007571 " Exposure -3- Exposure Iron dextran complex Iscniootinic acid hydrazide Isopropyl alcohol mnufacture (strangleid process) Isopropyl alcohol Isopropyl oils Imad and lead compounds leather dusts Leather goods mnufacture Leather tanning and processing Lusher and sawmill industry Magenta, mnufacture of Magenta Melphalan filtereaptopurine Methotrexate 5-Methoxypsoralen (+ UVR) S-Methoxypsoralen (+ UVR) Methyl bromide 4,4'-Methylene bis(2-chloroaniline) (MXA) 4,4*-Methylene bis(2-methylaniline) N-Methyl-N' -nitro-N-nitroeoguanidine Metronidazole Mineral oils Mistard gas 1-Naphthylamine 2-Naphthylamine 1-Naphthylthiourea Nickel refining Nickel and nickel compounds Nitrogen nistard Odiratoxin A Oxymetholone Rtenazopyridine (and its hydrobilaride) Rienelzine Fhenobarbital Rmoxyacid herbicides 2.4-D and esters 2.4-DP MC3A MCPP Silver ` 2,4,5-T and esters Phenylbutazone N-RTenyl-2-naphthylamine Rianytoin Polybrominated biphenyls Polychlorinated biphenyls Prednisone Procarbazine hydrochloride Propylene oxide Propylthiouracil Pulp and paper mnufacture Reserpine ftjbber industry Sacctarin Sepiolite BOR 07572 -4- Sex horsmes: Cbsfeinad oral aoitraceptives Sequential oral contraceptives Other oestrogen-progestin ccsbinatians Androgens: Testosterone Oestrogens: Qilorotrianisene Cbnjucpted oestrogens Dienoestrol Dicthylstilboestrol Diethylstilboestrol diprcpionate Ethinyloestradiol Hexoestrol Mestranol 0estradioi-17B and esters Oestriol Oestrone and oestrcne benzoate Progestins: Chlonoadincne acetate Diaethisterone Ethynodiol diacetate 170-Hydroxyprogesterone caproate Lynoestrenol Medroxyprogesterone acetate Megestrol acetateHorethisterone Norethisterone acetate Norethynodrel Norgestrel Progesterone Other: Claniphene Claniphene citrate Shale-oils Silica Smokeless tcbacoo products Soots (and soot extracts) Spironolactone Styrene Sulfafurazole Sulfamethoxazole Talc Exposure Tetrachlarodibenzo-para-dioxin (TQX>) % 1.1*2,2-Tetrachloroethane Tstrachloroethylene 2,4- and 2,6-Tbluene diisocyanates ortho-Toluidine TTeosulphan Tridiloroethylene 4,5`,8-Trimethylpsoralen (+ UVR) Tri s (azir idinyl J^ara-toenzoquincne (Triaziquone) Tris(l-aziridinyl) phosphine sulphidi (Thiotepa) Uracil xustard Vinblastine sulphate Vincristine sulphate Vinyl chloride Vinylidene chloride Nbllastanite Mood (lists BOR 007573