Document mmjXRQq7BL9jZeor642dVjBwO
6-month toxicitsytudy withPFOS Monkeys
Date: T-6295.7 Covance 6329-223 3/16/99
inCynomolgus
Urobilinogen(UB) AnalysisResultsfrom Dr Joseph P.McConnell.,Porphyrins and nutritionaBliochemistrylab,Dept of LaboratoryMedicineand Pathology. Mayo Clinic,Rochester MN.
Female
Average SD n
Average SD n T -TEST
Male
Average SD n
Average SD n T-TEST
mg UB/q
Control 0.078 0.017 6.000
0.75 mcjfka/d 0.112 0.075 6.000 0.357
mg UB/q
Control 0.097 0.031 6.000
0.75 mo/kWd 0.064 0.018 5.000
0.059(n--6)
6-month toxicitsytudy
inCynomoigus Monkeys
T-6295.7
Covance
6329-223
Date:
3116/99
UrobilinogeAnnalysisResultsfrom,Dr Joseph P.McConnell.,Porphyrinsand
nutritionBailochemisrylab,Dept of LaboratoryMedicineand Pathology.Mayo Clinic,
RochesterMN.
Animal number
Dose Level
Water StoolWeight Added
Total Weight
mg UB per gram specffied
105529 1F 105530 IF 105531 IF 105535 IF 105544 IF 105549 IF Average SD n
10.0
10
20.0
0.07
8.0
10
18.0
0.11
9.0
10
19.0
0.07
4.0
10
14.0
0.08
8.0
10
18.0
0.06
6.0
10
16.0
0.08
7.5
10
17.5
0.08
2.2
0
2.2
0.02
6.0
6
6.0
6.00
105533 4F 105534 4F 105536 4F 105540 4F
105542 4F 105551 4F Average SD n T -TEST
13.0
10
23.0
0.16
9.0
10
19.0
0.08
12.0
10
22.0
0.24
10.0
10
20.0
0.09
6.0
10
16.0
0.05
5.0
10
15.0
0.05
9.2
10
19.2
0.11
3.2
0
3.2
0.07
6.0
6
6.0
6.00
0.36
105508 im 105517 1M
105519 IM 105520 IM 105526 IM 105527 IM Average SD n
6.0
10
16.0
0.15
10.0
10
20.0
0.08
8.0
10
18.0
0.10
10.0
10
20.0
0.11
7.0
10
17.0
0.07
8.0
10
18.0
0.07
8.2
10
18.2
0.10
1.6
0
1.6
0.03
6.0
6
6.0
6.00
105506 4M 105507 4M 105511 4M 105512 4M 105522 4M Avemge
SD n T-TEST
8.0
10
18.0
3.0
10
13.0
10.0
20
30.0
6.0
10
16.0
7.0
10
17.0
6.8
12
18.8
2.6
4
6.5
5.0
5
5.0
0.09 o.04 0.06 0.06 0.07 0.06 0.02 5.00
0.059492809 (n=6)