Document mbzp9eo97w4vJE5xoj90q1g9Z
CENTRAL ANALYTICAL
LABORATORY
Report No. ---@219 -----------Date--- --May-- 16,- 1978 ------
Subject: F C-143 Analysis of IRDC 137-090 Samples
Requestor:
Dept. Name ---T,(Z4iCQlggY-
Request No.
------
Dated
--------
Report:
Proj. No._2121,LU004
Serum and livers from IRDC study 137-090 (90 day subacute rhesus monkey toxicity with FC-143) were received for analysis of FC-143 content.
Monke@p
Dose
Survival
Serum PPM
Liver ppm
Liver total_v_l
7362M
0
7386F
0
yes
0.05
3
yes
1
0.07
5
7364M
3 mg/kg/day
yes
7366M
01
yes
7384F
of
yes
7385F
to
yes
53
3
48
-
65
7
50
250 -
350 -
7363M
10 mg/kg/day
yes
7458M
yes
7328F
yes
7383F
yes
7367M
30 mg/kg/day
no
7 4 5 5,L4
it
yes
7382F
if
no
7387F
it
no
45
9
71
79
71
10
-
125
145
60
-
80
-
125
600 -
750
8000 400 0 7500 9000
7456M
100 mg/kg/day
no
7381F
no
(D
M = male,
F female
-
100
-
325
--
6000 20000
A.R. #t)919
2
14ay 16, 1978
Altliougli no effects (preliminary observation) were seen during the 90 day rat study at 10 - 1000 ppm FC-143, the monkeys at the higher dosage levels were adversely affected; however, the monkeys were studied at approximately 100 times greater concentration than the rats.
Note that both male and female monkeys accumulate FC-143 to about the same extent whereas with rats, only the male was found to contain higli levels of FC-143. It is interesting to speculate regarding the conclusion of Prof. Singer's latest study with perfluorooctanoic acid. He used a female rat and found rapid excretion of the compound. has lie also studied a male rat to verify either his female study or would tiie results agree with the IRDC (137-089)study?
one obvious question, wliat is the difference acid, ammonium salt and FC-143?
in toxicity
of octanoic
/jz c:H.E.
J.D. B.W. R.A. F.A. D.G.
Preier LaZerte Nippoldt Prokop Ubel Welblen
201-IS 236-1 201-lS 236-3B 220-2E 201-lS
n Belisle