Document mbd2J84BXLMNEMeNX9vj5vB

Induetrial Hygiene Digest - 27 January, 1950 Injection an the hellies of rabbits, are comparable .to those of ethyl __ crotanate dimethyl phthalate. It. is .as, Irritating to the corneas of 'rabbits as ethanol and about one twentieth as irritating as ethyl crotanate. Concentrations, of ethyl acrylate: vapors of 4000, 2000, and 1000 p.p.m. killed all of blx, five of six, and none of six rats respectively in four hours. Saturated vapors, concentration 50,000 p.p.a. killed all of s lx In fifteen minutes, and none in five minutes. Babbits and rats suffered lung damage and secondary effects In liver and kidneys from repeated 50 day exposures to a concentration of ethyl acrylate of 500 p.p.m. Bats were , not significantly affected by a 50-day exposure to 70 p.p.m. ethyl acrylate. These findings suggest a hygienic standard for repeated human Inhalation ' of ethyl acrylate vapors of not above 50 p.p.m. -- Condensed from Authors1 Summary 85 The Toxicity of Methyl and Ethyl Acrylate. J.F. Trean, H. Sigmon, B. Wright, and K.V. Kitzmiller. J. Ind. Hyg. & Toxicol. 51, 517-526 (Nov. 1949). Animal experiments lead to the tentative conclusion that men may breathe air containing concentrations of the order of 75 p.p.m. (0.26mg. of methyl acrylate per liter or 0.50 mg. of ethyl acrylate per liter at 25C and 745 mm. of mercury) for periods of several hours per day without any con-? slderable likelihood of Injurious effectB. This presumption should be accepted cautiously In practice and careful medical supervision should be maintained until the facts with reference to human susceptibility can be established. -- Condensed from Authors' Summary 86 Fatality and IllnesB Caused by Ethylene Chloride in an Agricultural Occupation! A.F. Bush, H.K. Abrams, and H.V. Brown. J. Ind. Hyg. & Toxicol. 51, 552-558 (Nov. 1949) (l) Ethylene chlorhydrin is now widely used in rural areas to hasten the germination of seed potatoes. (2) This chemical recently caused the death of one the illness of five persons who were engaged In this occupation. The clinical and autopsy findings are given. (5) Ethylene chlorhydrin 1b a potent poison with special effectB on the nervous, hepatic, renal and vascular "systems. It is absorbed readily through skin,. intes tine and respiratory tract. (4) The maximum allowable concentration should be. lowered to 2 p.p.m. In atmosphere, and no contact with the skin should be permitted. (5) A method of safely applying ethylene chlorhydrin to potatoes Is described, (6) Mechanical ventilation is recommended for all treatment chambers. Five hundred continuous air changes seem necessary before a chamber Is opened. The ventilation should "remain on" during unloading. (7) Proper'health-control should Include medical examinations and engineering controls. . . -- Authors' Summary 87 The Betentian of Methallyl Chloride and Methyl Bromide .by Fumigated Grain. N, Van'Tie1 'J. Hygiene. 46, 451-455 (Dec. 1948). ~ While the toxic properties of methyl bromide are greater than those of methallyl chloride it is more volatile and evaporates mare rapidly from grain that has been fumigated by it. Bowever, there was no mortality in groups of rats that were fed far bIx and one-half weeks an grain that had been fumigated by these substances. Diere were ho significant differences