Document mYYKo6pzNw9qVOoRxgMZ4LvJ

CHEMICAL MANUFACTURERS ASSOCIATION January 3,1995 Dear Vinyl Chloride Health Committee Members: The agenda for the January 30,1995 meeting is endosed. As mentioned in my December 9,1994 letter, Drs. Ken Mundt and Carlo Tamburo will attend the meeting. Discussion with Dr. Mundt will enable him to collect new data for the epidemiology update more efficiently. Discussion with Dr. Tamburo will enable the Committee to decide on a course of action with respect to the proposed brain cancer case control study. The October 6 and 7,1994 Records of Meeting and subsequent Records of Conference Call are being mailed to you separately. Information on agenda items 5.0, 6.0, and 7.0 is enclosed. I will follow-up with Dr. Holtzer of Cal-EPA on vinyl chloride risk assessment near a hazardous waste landfill. Please discuss Dr. James Swenberg's proposal with your toxicologists prior to the meeting. I will request a more detailed proposal from Dr. Swenberg if the project merits further consideration. I will contact Dr. James Cogliano of EPA to learn the process for modifying the Heast Table. The Heast Table predicts a much higher vinyl chloride unit risk than estimated by Richard Reitz based on the pharmacokinetic data. I am looking forward to seeing you on January 30 and I wish you a very happy new year! Sincerely, Enclosures Hasmukh C. Shah, Ph.D. Manager, Vinyl Chloride Panel 250' M Street, NW, Washington, DC 20037 Telephone 202-887-1100 Fax 202-887-1237 BFG 00122 LfJ Responsible Care W A PublicCommitment CHEMICAL MANUFACTURERS ASSOCIATION Vinyl Chloride Health Committee Tentative Agenda Date: January 30,1995_. Time: 10:30 a.m. - 3:30 p.m. EST Place: CMA Offices 2501 M Street, NW Washington, D.C. 1.0 Approval of October 6 and 7,1994 Records of Meeting 2.0 Discussion of Vinyl Chloride Epidemiology Study Update with Ken Mundt , v. 3.0 Discuss*ion of University of Louisville's Proposal for a Brain Cancer Case Control Study wvijth Carlo Tamburo -//? rrco-' 1 % (( Tut \ 4.0 Status of ATSDR and EPA Responses to the Committee's November 28 Letters) for a Negotiated Voluntary Program and Discussion of a Course of Action Caffey Norman ( Cx^ f "G A i S. A C -T.V u*_". AtA--'. \^ h 5.0 Status of Cal-EPA Risk Assessment of Vinyl Chloride Near a Hazardous Waste Landfill '^' t (x> i^t s~ &~233pA , 'A .Xtx.Jsw. Tt- --v- ^'/r _ 6.0 Discussion of Richard Reitz's Manuscript and the Committee's Course of Action with Respect to Modification of the Heast Table --x* \ Cc>- 7.0 Discussion of James Swenberg's Research Proposal 8.0 Discussion of International Workshop on Vinyl Chloride 9.0 Distribution of Financial Statement 10.0 Set Date for Next Meeting or Conference Call Subject to Approval if 0-0 Hasmukh C. Shah, Ph.D. Manager, Vinyl Chloride Panel BFG 00123 Tbc School of Public Health Dtptrtmciu of Environswnul Sacnect and Enfintcnni THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL The Umw**y of Nonh Carolina at Oipd Hill CB 7400. ftottsiau Hal) Chapel HiU, N.C. 27J99-7400 October 19,1994 Dr. Hasmukh C. Shah Manager, Vinyl Chloride Panel Chemical Manufacturers Association 2501 M Street, NW Washington, D.C. 20037 Dear Dr. Shah: I enjoyed seeing you at the CUT Open House last week. This letter is a follow up to our conversation regarding the discussions that the Vinyl Chloride Panel held following our visit to the EPA. 1 would be interested in working with you on some of the issues that axe still of concern such as determining the T1/2 of the ethenoguanine DNA adduct (EG), and quantitating the amount of the methyl purine DNA glycosylase (MPG) and P450 2E1 in tissues of humans of different ages. We discussed the approach that 1 would use to determine the Tia of EG. This would require the synthesis of [13CJ-vinyl chloride. I would then expose groups of 3-4 rats using the closed chamber technique to the stable isotope and sacrifice them at different times (0,4,12, and 24 hours) after a 6 hour exposure to -1000 ppm VC. This would be repeated several times to determine the average T,* Of EG using our GC/ high resolution MS methodology. Dr. Johannes Filser will visit me next week and X plan on discussing the details of the animal exposure with him, as he is an expert in the closed chamber technique. We are just setting up a quantitative polymerase chain reaction (PCR) method for measuring the expression ofthe MPG DNA repair protein We plan to evaluate age differences in rats and mice under our Superfund Basic Research Program proposal, providing it gets funded. What 2 hadn't considered until I met with the VC Panel was doing this in human tissues of different ages. This may require slight adjustments in methodology and the synthesis of different primers. I believe that 1 can obtain human tissues from various tissue banks such as Vanderbilt University and the University of BFG 00125 TQ FROM : PHO NO. : 0012019906633 OCT. 12.1994 11:48PM Pi A^ME ASSOCIATION Oi` IM.AVIICS MAMIIMCPUHHRX IN mMOPh Brussels, 12 October 1994 To the attention of Mrs. Meredith Scheck The Vinyl Institute Fax: 00-1-201-890-7029: This note to let you know that I have been contacted recently by Mr. R. Holtzer M.D. from California * Environmental Protection Agency, Hazardous Waste Toxicology Section, requesting information about the cases of ASL linked to occupational exposure to VCM. The Agency is conducting a "Health risk assessment, of exposure to Vinyl Chloride in a residential community immediately adjacent to and downwind from a closed hazardous waste landfill". T sent some extracts of the ASL Register, and specified that all the reported ASL cases occured after a continuous and very high exposure to VCM and that, so far, there has not been any ASL cases reported by workers first exposed after the mid-seventies, which is the time when exposure to VCM was drastically reduced in Vinyls plants. Yours sincerely F. Drion M.D. Medical Working Group of A.P.M.E. BFG 00127 & ** TOTAL PAGE.02 **