Document mQyD8e5mn5dGaGp7jkayM47g

r -I/i. i pi M nh*ytf Vi.I /I, ICK.7U / J'b p ii: 'min:', mill in mi. ill. fit i- 'ivi* |i t.lio.i, me <'i mi ill .util i'ip slnkiit,; sitml.irii n * Im-iwviii ibcm ii -i-ii. |i ilr. -iii,it.i< 1li.il i'li may Ik* ii imir ik*h ilinn,mii in iln. p-ub*. i.. 1 In* Jlaiii test (Davis .uni AikIi Imaii, In*,.') v.,is it* il fr lilt* ilrln. of urinary i-nuiiunlevtihuic :irn| ill kid-, in p.itimis ami eniitrolx. Results * In twi'tl an mint nsnndy snoidie.inl no* in I levels between controls ami linlicaiiil pnlnnli ..ml pilieiils treated with Li.CCh. Li may interfere with lib synthe-is in a similar way to I'll. *11 references. S. M. Maxwell 89010s Effects of DTPA Idiethylcnetriaminipcntaacelic acid} aerosol on lung contamination by lanthanum. Pastiuier, Christian; Vnisin, Dominique; Thieblemont, Pierre; Permult, Gorartl; Bayard, Jiau 1*. (Ihr. Prot. Stirele Kuilml., C.K.N., rontenny-aus-Kiisei, I*r.). Cumims. Emrg. .It. |/*V.|, h'app. 1909, CEA-R-3733, 10 pp. (!>). Avail. CEA. liy use of DTPA aerosol in the treatment of pulmonary contamination by La, its effectiveness was detd. as a function of time. Provided that it is administered at an early stage, in the 2 hrs. after expo sure. >oQ/ can )>e ilimiiiatrd using lower IhcraiK'ULic doses titan those prescribed for oilier methods of administration. Its assocn. with some enzymes did not enhance the therapeutic effect of the chelator. The const, for the passage of tlie DTPA- La complex from the lung to the blood is --0.016/ min., corre sponding to a period of 44 min. A significant nonchctalable fraction, persisting after prolonged action of the DTPA, of the order of IMS',; is observed. ^DWJF 89617t Ferric cyanoferratcfll): an effective antidote in thallium poisoning. Hcydlnuf, Horst (Inst. Strahleiilhol., Kernforschungszcmrum, Karlsruhe, Gcr.). Ear. J. Ptsarmacol. 1969, 6(3), 340-4 (Eng). The influence of orally administered ferric cyanofcrrate( 11), (Prussian Dluc, PE) on the distribution and excretion of ***TI was studied in the rat. PB lowered the retention of *"T1 by inhibition of its absorption and rcabsorption from the intestinal tract. The toxicity of TLSCL was decreased by PB. EB is suggested as an antidote in T1 poisoning. V. N. Gupta 89618u Cycloheximide-induced ultrastructural changes in the adrenal cortex of the rat. D/sinich, Cs.; Ezalyi. U.; Okros, I. (Inst. Exp. Med., Hung. Acad. Sci., Budapest, Hung.). Expcricnlto 1969, 2-3(3), S33 6 (Eng). Wistar rats of both sexes weighing about LSI) g. were used. Conspicuous changes in the ultraslructure of the zona f.nCK-ul.it.i cells were oliserved follow ing decapitation at nil min. even after the lowest (.7 mg.) dose. At low-power magnification, compact masses of irregular sltapc, medium d. and blurred outlines were seen to have accumulated between organelles. In expts. involving both cyeloheximide and ACT!I treatment, the changes were similar, although the cells ap)>carcd swollen. Similar observations were made in some cells of tint zona reticularis, but not in tlie zona glouicrulosa.. The findings suggested a correlation between the substance seen to accumulate among organelles and the increased cholesterol .content of the adrenal cortex. The ullrastruclural changes were the consequence of an impairment of the enzyme system. P. J. Parisck 89619v Effect of acetone on the level of ketone bodies in the blood and urine of experimental animala of different species. Linyucheva, L, A.; Tiunov, L. A.; Kolosova. T. S. (USSR). Farmakol. Toksikol. (.Moscow) 1969, 32(4), 403-7 (Russ). Rats and mice exposed to 30 mg. McjCO/l. and rabbits and guinea pigs exposed to 72 mg./l. for 2 hrs. showed increased levels of MciCQ, acctoacctic acid, and 3-hydruxybutyric acid in their blood and urine immediately after inhalation and 24 hrs. later. In all 4 species the fl-hydroxybutyric acid level increased to a greater extent than did the other ketone bodies. The largest in creases in the NfctCO and acctoacctic acid levels in the blood both immediately and 21 hrs. after acute inhalation occurred in rats and tlie smallest changes ap|>eared in rabbits. IIJ J R 89620p Mature of the acute action exerted on the organism by monoethanolcthylcnediamine. Tikhonova, I1.; Sidorov, K. K. (Inst. Mcd.-IJiol. 1`robl., Moscow, USSR). Farmakol. Toksikol. (.1loscmo) 1906. 32(1), 473-3 (Ruse). Muiincthnunl- Cthylcucdinmiiic 11) injected into tlie stomach of rale in a max. tolerable dose (2.3 g- kg. in .Uu). ,u|. sulu.) disrupted tlu* acid- base balance in the bloiKl after 3-3 hrs,, increased the fill frutn 7,18-7.35 (control) to 7.4-7.40, and increased the level of free basts. One day after I injection the Ca level in the scrum in creased, the time of blood coagulation decreased, tlie blood pll dropped to 7.11-7.21, ami the amt. of free bases was below nor mal. The level of globulins decreased and the content of albu- n in- mcm-ed in lln- bln,id: ilie lev 11 of et'-Iolid, - in the urine decreased. I t.lU-et. net-.-,i *,,:.* ... *i., live system or. am, ptnb.d,!y tar..-a i.s: I.;,;ir-*|- .; --i. It I i I; 89021q Changes in cdien.dine like substances in labbit blood following chronic exposure to vinyl chloride lumcs. Varan, A. N'.; plokhuva, E. I. (Inst. Gig. Tr. Prof/.abol., Gorki, USSR). Cig. Tr. Frol. Zabol. 1969, 13(6), 40-7 (Russ). A group of 8 chinchilla rabbits was exposed for 4 hrs. daily, during 5 months, to the vapors of vinyl chloride (I) m air at 0.02- 0.03 mg., I. Samples of blood were taken from the ear veins and analyzed for adrenaline (II) and adreiialme-likc tUa) substances. In fin r 1 In* i v |*i mi* t** I and a I .ii in I In* n.iiti i*l i-itiU|i of i a Mil I *. Il"1 H ami 11a li'vet-. Valii-il little anil avvtagvd .1,3 ,,|.r' After I'li dav *. r\|si ilie ilu* h vt I of II and lln m e in li.l.", ,,1*,.'after -Id dae- it tiaehid fkti ,, amt it feuiauied eiiusi, tbeieafter. Tag liiopiuetni d of the posterior hypothalamus also changed. 1 In le cflcrli of 1 .III* till dine I I'.llln* of hy)iet leusiou, CPJR 8'ffi22r ATP and lipid euiiteids in the liver of mice after in halation of chlorinated hydrocarbons. Ogata, Mamiia: Tomo- kuui, Ktitsumaio; \YatauabC, Shinsaku (Med. Sch,, Okayama Univ., Okayama, Japan). Ini. Health (Kawasaki, Japan.) 1963, 0(3), 11G-!) (Eng). The hepatic ATP level decrease and the onset of fatty liver as indicated by the increase in the amt. of tin- total lipids ami triglycerides in the mice exposed to 3 kinds of chlorinated liyilrwarhoiis arc in tlie following order: CCL, tetraclilorocthylenc, and trichloroethylene. The total lipid and triglyceride contents increased proportionately to the fall in the ATP level before and after the exposure to 3 kinds of chlorinated hydrocarbons. It was suggested that there is some close rela tionship between the decreased hepatic ATI' levels and tlie de velopment of fatty liver in chlorinated hydrocarbon poisonings. U. V. Shclty 89623a Influence of subacute intoxication with manganous chloride and carbon tetrachloride on the lethal dose of digitoxin, lanatoside C, and strophanthosida in guinea pigs. Leuce, 1'.; Valctuineie-Budihna, Mclka (Med. Fac., Ljubljana, Yugo slavia). Ihuoslur. Physiol. Pharmacol. Acta 1968, 4(2), 157-04 (Eng). In guinea pigs the toxicity of the title cardiotonic gluco- sides is modified in suljacitlc intoxications with MuCb and CCi* (when evident morphological changes are restricted to the liver). The following doses were used: 0.01 ml./kg. CCL in 2'i> oil soln. and 0.003 g./kg. MuCL in 3% aq. soln., i.in., twice a week, or 10 times successively; glucosidcs were administered 30-39 days after the last dose of CCL or MnCL. In intoxicated guinea pigs the lethal dose of digitoxin did not differ significantly from that of controls. The lethal dose of lanatoside* C was significantly smaller only in CCL treated animals and the lethal dose of stro- phauihusidc was significantly smaller in both intoxicated groups, G. Muacevic 896241 Antidote! for phosgene-induced pulmonary edema, lloyd, Eldon M. (O'tceii's l iuv., Kingston, Ont.). J. I'ltarm. Pharmacol. I960, 21(3), 337 (Hug), Death rates from phosgene werc reduced in rabbits, cats, mid rats if vhc animals wrre allowed to inhale the phosgene through the nose rather than directly into the trachea. David B. Sabine 89625u Demcthylphalloin. Puchingcr, Ilcnvtg; Wieland, Theodor (Univ. Frankfurt, Frankfurt, Gcr.), Justus Liebigs Ann. Chem. 1969, 723, J3S-40 (Gcr). Dcnicthyiphalloiii-*// (I) was ohininrd by redu. of the CO group of ketopli.dloidiu with IM,'dieted NaRIL- I had almost the same toxicity ax phalluidin. During storage I gave a degradation product whose uv spretrum indicated a sulfoxide structure. HTJG 89626v Histochemical study of cytochrome oxidase and succinic dehydrogenase activity in encephalon of rabbits poisoned by alcohol. Lo Memo, G.; Chiara, A. (Univ. Catania, Catania, Italy). Mtd. Leg. Assicurazioni 1968, 10<3-4), 103-72 (Eng)'- An increase in both cybichromc oxidase and succtmc dehydro genase was observed in the cells of the cerebellar cortex of rabbits which had undergone either chronic or acute ale, pinioning, as compared to the conpoisoued control animals. No change was evident in other encephalic regions. The increase of these en zymes at cerebellar level agrees with the symptomatologies! data indicative of functional damage of the area during ale. poisoning. Murrie V. Burgan 89627W Nicotine degradation in hamsters and rats and its modification by foreign substances. II. Effect of carbon mon oxide treatment of the animals on their nicotine metabolism, liarkc, Hans 1\; Fralim, II.; Schultz, Cli.; Donunwill, W. (Inst. Wins. Forscliuiigstcllc VYrbaud, Cigaretteuind.. Ham burg, C,cr.). Nalurwissettscha/lcn 1969, obi3), 413 |Gcr). Deg radation of nicotine to cotmiuc ill rat and hamster liver homog enates was not affected by prior exposure to CO. GKJG 89628s Toxic effects of calcium, titanium, anil niobium borides in rats Ka*-p.irov, A. A.; /.Inlova, N. A (USSR). AT:*. Donnye Tokuko!. KcJk. .Metal. Iklt Moctlin. 1967, 152*t'*) IRuss). Emm K.f. /.I:., Farmakol.. Khiaiiotcr. Sreistta. 7V8ri- kol. 1968, Abstr. No. 7.3-1.779. LD^ of CaB (I), during i.p. administration to rats, was 1.UI3 ing. kg. Intoxication with I is expressed by depression and disorder in movement coordina tion. Chronic oral administration of I to rabbits (100 mg. kg./- day for 4 month.*-) caused leukocytosis. lymphocytosis, increase in if.uti. *f . - ;*1|,l;i;11ii m,,| activity of aldolase, ami ibercj-e in albmnn in Mih-I. I'rotliromimi m blood -t 3. ,;::iiin. d - creased ami tai d increased to the cud oi expl. In lit.:.,i tli.re was polyei.iia of ti'sites and ihiekriiing of interalveolar septums. Ill intestines there was sclerosis of all vessels in snbumens d layer, tkcrcased glycogen in liver, and accumulation of ae*d mucopolysaccharides in the region of hepatic triad. Moderate intensification of lung pattern was observed by \-ray studies m animals 6-9 mouths after Single intratracheal administration to rats of Ti boride (II), Nb boride i.III), and esp. of I ,30 mg.i. OLI 5124