Document mBrnwY4k4dDJ8Y0xgqk2VJ3Q4

FILE NAME Quebec Asbestos Mining Association QAMA DATE 0000 DOC QAMA025 DOCUMENT DESCRIPTION Abstracts of QAMA Research Projects 1970s JHE oo7g7 Project No. 4 - Ultrastructural study of experimentally induced asbestos granulomas in hamsters 4, Samples of chrysotile obtained from Dr. Holt Reading to be injected into the peritoneal cavity of hamsters Formation of asbestos bodies to be investigated by classical histology microscopy and histochemistry Other samples of chrysotile to be injected into Selye's granuloma pouches pouches Local reaction to be investigated and its mn modification by various agents incl P204 P204 Cost 11,266 Dr. Andr^' Dumont M.D. & Dr. A. Alcindor M.D. Universit^' de Montr^'al Montr^'al CANCELLED ~ : JHM 00768 SUM 00759 Project No. 5 - Epidemiological study on the biological effects ans of asbestos dust at the Balangero Mine and among the Port of Genoa and LaSpezia Arsenal insulation workers Epidemiological study of all workers past and present of the chrysotile mine and of a representative cohort of insulation workers from the shipyards and environmental study of their dust exposure Objectives are ) Does the inhalation of asbestos fibres bear any relationship with a the occurrence of carcinoma of the lung and b the occurrence of mesothelioma of the pleura and the peritoneum 2 Do people exposed to the inhalation of very low concentrations of asbestos dust such as workers exposed to concentrations well below any threshold limit or people living in villages in the vicinity of asbestos mines exhibit an abnormally high incidence of calcified pleural plaques 3 Do the different types of asbestos behave in the same way in regard to lung cancer mesothelioma of the pleura and pleural plaques or is one type of asbestos prevalent among the others as a causative agent Dr. Enrico C. Vigliani Clinica del Lavoro Milano Italy M.D. Cost 85,000 JHM 00770 r DAIL DOCUMER INGERED INGERED soo : ' ade ody 1 t 21 DOCUMENDOCUMEN mie EDITED BY PAGE a 194 Ghezzi I. Aresini G. & Vigliani E.C eee ee OF \ DOCUMENT MO 3864 LOCATION KEY CODE KEY WORD OR CHARACTERISTIC SCOPE NOTES -~ asbre isks ofaast bsebseto sotsoss iIstii n a s mine of chrysotile 12 Il rischio di asbestosi in una miniera di 13 amianto crisotilo 14 La 36 37 38 43 60 70 85 A ah Medicina del Lavoro 63189-21 1972 2 | tile usbestos The Authors have carried out a study of the causes of death and a study of clinical epidemiology on the working population of a mine of chrysotile asbestus in Bar langero In this mine between 1932 and 1970 1098 workers have worked for at least one month of these 242 were at work un March 31st 1970. Informations could be obtained in 998 workers that is 90.8 % of the total population 270 subjects have died a 6 of these 2.2 % died from lung cancer No case of serosal mesolbelion was aster- lained The percentage of lung cancers was not significantly different from that observed in muile subjects of the same age who died in the same period in two towns of the area where the nune is situated Aelinico radiological examination and a stude of the respiratory function dave been carried out in workers at work since more than one year 29.8 % of 474 subjects showed an ray pattern classifiable in categories 1 2 and 3 of the CINCINNATI classification the highest percentage of subjects 48.6 % with abnormal ray pattern was observed in the groups at highest risk 51 subjecis sbowed fibroue changes of the pleura 10 of which with calcific opacity The respira tory function test performed were the vital capacity the maximum expiration volume in one second YEMS the capillary dillusion at rest and at work steady state method half subjets with abnormal ray pattern showed a venulatory insufficiency restrictive in type while approximately one third showed a damage of capillary diffusion In 14 workers with a completely normal ray pattern an impairment of capillary pas diffusion was demonstrated in at least 5 of these cases all at bigh risk be existence of any other possible pathologic cause except asbestos exposure could be ruled out 25 of the workers who received physical examination was found to have chronic bronchitis no correlation was demonstrated between chronic bronchitis and asbestos exposure The physical examination showed the existence of fine crepitant rales at the thorax bases in 27 % subjects with abnormal ray pattern the highest percentage of subjects with fine crepitant rales was detected in the group with the highest risk The linging was present also in 7.5 of the radiologically normal subjects On the basis of the clinical and functional data it seems possible 10 confirm that an impairment of capillary diffusion of gases and the appearance of bibasilar fine crepitant rates can constitute one of the carly consequences of exposure to asbestos even in the absence of pulmonary changes radiologically evident CASION K^ TDES~IM- MOULL FORM KQ TL KR Q TL R / INDEX TRACING CARD AVI JHM 00771 . of l; dy ' la if, a of ft NUMRIM NUMRIM IRUSBED HY ot afr tt ads adr ads 3 CUILD T GOCUMENT a2, DOCUMENT TILE PAGE Ghezzi I. Maranzana P. & Zannini .: KEY CODE 3 10 36 KEY WORD OR CHARACTERISTIC CHARACTERISTIC t Considerations on asbestosis in Piedmont Ligurianad Lombardy It 38 Piemonte Liguria e Lombardia 60 Medicina del Lavoro Lavoro 62 111-119 1971 61 111-119 1971 62 63 43 mo LA TTG S OOU M FE oon core Since 1943 when the compulsory insurance against asbestusis was started in Italy 1530 workers were compensated by 1.N.A.I.L. for asbestos pneumoconiosis in Piedmont and in the provinces of Milan Bergamo and Genoa out of these 1205 were sull Ite ving on March 31 st 1970. The asbestoses of moderate or advanced degree constituted 31 30 42 70 85 32 of the cases such percentage was higher than 50 if one considered only the workers who had been employed in the textile industry and in yards Pleural ebanges both calesfic and not were radiologically demonstrated in 52 of asbestolic subjects who had worked in textile mills while among the former chrysoule miners such changes resalted to be present only in 14 of the subjects Out of the 325 dead workers compensated for asbestosis 165 57 % died due to causes directly related to asbestosis asbestosis respiratory insufficiency tuberculosis pleural and lung tumours Pleural and lung tumours were found in 34 subjects that is 10.5 of the dead cases | such percentage rose to 26.3 ^ if one considered only the 61 autopsied cases in 16 of whom the presence of a pleural or lung neoplasia was found The incidence of pleural and lung tumours was maximal 19.5 % and minima_ l 2.6 % | among the miners who in this last group no pleural mesothelioma was among the former had been exposed found insulation workers only ta chrysotile . _ _ _ Beside,s the epidemiologic data the results are reported of 466 measurements of air dustiness carried out in as many work places in 36.3 % of the counts the asbestos T concentration was higher than 12 fibers The maximal concentration of asbestos eet was observed in the atmosphere of a textile department carding |. ots or 4 A . = ee DOCUMEN^ k 3586 LOCATION SCOPE NOTES a Book A III aensem YEA CANT - MERCE FORM 1930 INDEX TRACING CARD F) JHM 00772 ee EDILL = by AT DAIL re SS SE = VOLUMENTY VEDIC PAGE . DOCUMENT DOCUMENT TITLE PAGE OF 3839 3839 _ Sartorelli E. Zedda S. Aresini G. & Ghezzi .: LOCATION KET CODE KEY WORD OR CHAHACTERISTIC SCOPE NOTES 113 3 Respiratory physiopathology of asbestosis Italian Fisiopatologia respiratoria dell'asbestosi 61 La Medicina del Lavoro 63 7-8 269-281 July 1972 62 ( fm ) deren Welch 70 / i ) 85 III 843209 REYDES CIN MEBLE FOFN FIM DOCUMENT DOCUMENT TITLE | Vigliani Vigliani Vigliani Vigliani Enrico Enrico INDEX TRACING CARD | PAGE KEY CODE 20 21 KEY WORD OR CHARACTERISTIC Fibrogenesis The fibrogenic to asbestos response 25 Lu 45 48 73 DAMA 2nd Antigua Conference IV 151-167 Nov. 22 | Medic deliLn avoa ro 6-7 407- 410 1968 1967 . 85 OF wt ~ SCSoCS. 2870 2870 LOCATION eee SCOPE NOTES 00773 CHM CHM CHM 00773 00773 00773 00773 : tee DATE . 3651324 ki : . ~ Voto ce we DOCUMENDOCUTMENT liter meee PAG eo Vigliani Enrico .: KLY CODE et CODE KEY WORD ON CHARACTERISTIC MAC 2 Criteria for determination 3 ofasbe ans d at sbo ests os in the air It 40 determinazione Criteri per delle determinazione 43 concentrazioni tollerabili e silice amianto nell'aria _ 48 | Med Lavoro 60 85-89 Feb. 1969 85 List # 4 i ay ar DOCUMEN1 AJ 3333 LOCATION LOCATION SCOPE NOTES and The Preventive paper given at the International Congress of Hygiene Medicine in Rome 1968 describes in some detail the Italian hygienic norm for prevention of silicosis & ( 29 4. 29 R = where R hazard of pneumoconiosis Q % of free silica in dust N number of particle5s micron in 1 cc of air Sennen " ALTOLA INI - MEBLE F^ RNKEILLA DOCUMENT TITLE . ' Vigliani Vigliani Vigliani Vigliani . E.C es a INDEX / TRACING CARD . JEBUL we cee ee eee 3291 LOCATIO 3291 3291 KEY CODE 70 Asbestos KEY WORD OR CHARACTERISTIC Exposure and its Results in Italy SCOPE NOTES 61 International Conference LaMedicina del Lavoro paper 325-330 May 1969 on Pneumoconiosis Johannesburg April 1969 62 SUMMARY Of 307 deaths among asbestosis compensation cases in fou 36 38 85 __ Italian provinces 31.6 died of asbestosis 10.8 of cancer Lung and pleura A minority of subjects were autopsied and of thes thes subjects exhibited a higher mortality from asbestosis 42.4 and and Lung and pleura number of lung cancers 27.1 tumors found at The author necropsy is comments that rather high the Four types of asbestos workers were studied miners textile and frict the indicate products asbestos and insulation workers Mining has thelowesantd insulation the highest incidence of tumors of the lung study on dockyard workers is also under way Prel hary findings_among findings_among this group in the incidence 9.4 of tumors of the Nosignificant differen lung was seen between workers with continuous and intermittent exposure to asbestos -- Pneumoconiosis -- H ry , i PROCEEDINGS Internat mom eee. - ce 4 tee we + aa JHM00774 JHM00774 pp .192-190 a ee ee published published 1970 + - ( een! " 1 DATC i " ee 2 INDERED BY 1 48 -- , = d, ed: VOLUMENT 2 il, ata EDITED ST ; DOCUMENT NO DOCUMENT wa TITLE Vigliani Maranzana KEY CODE PAGE Of 3091 Vigliani Vigliani Vigliani Ghezzi E.C Ghezzi .; Maranzana Pernis .; Maranzana P. & LOCATION B. KEY WORD OR CHARACTERISTIC SCOPE NOTES 36 Epidemiological Study of asbestos 38 workers in Northern Italy 60 La Med del Lavoro 59 481-485 : 43 Aug.Sept 1968 61 . 62 62 31 70 ceed ~ 85 85 SUMMARY During the period 1943-1967 265 workers 209 men and 79 women compensated by the INAIL for asbestosis died in Piedmont Liguria and Lombardy Trirty two workers had been engaged in asbestos mining 161 in manufactures fasbestos brake and friction products 60 in the production of asbestos and 35 in insulation works Out of the 288 dead workers 28 10 died from a lung tumiaur . _ ~or from a mesothelioma of the pleura 36 from neoplasias at other sites 93 from www respiratory discase complicating asbestusis 22 from tuberculosis $ from other causes in 28 cases the death cause could not be determined In 56 cases the ~wm autopsy was performed among these cases Jung and pleura tumours constituted the 23 wT The percentage of lung tumours among the male asbestoties was approximately twice ___ ] that observed among the inhabitants of Milan Turin and Pavia and approximately ae | 8 times higher than that of silicotic patients who died in the same period Among . the 32 miners who had been exposed only to chrysotile the incidence of lung tumours resulted to be 3.1 lower than that observed among other categoris of asbestos worke_ rs _ textile and friction products asbestos and among the insulators 127 , Sorter KEYLA 192 MEALL FORM 113 INDEX TRACING CARD JHM 00775 DOCUMENT TEL KEY LODE aot fe Pp bt tt c Seles: 2 sas 3 oY ne Vigliani Vigliani eons & HH ee eee eee roe we pes ee er fe Mem Ue eh HUMI 124 2 ee SSS sles 1 ' LOOCUMENT NU E.C. & Pernis B .: = KEY WORD ON CHARACTERISTIC CHARACTERISTIC CHARACTERISTIC LULATION Maranzana P. , Chezzi -I eee SCOPE NOTLS Study of Epidemiolorical 60 in Northern Italy Asbestos Workers International_Conf 12- 12- Biological Effects Asbestos Dresden April 1968 42 Proceedings published 1973 pp 147-150 85 . . 2001. BITURA LIM BITURA BITURA ( MEBLE FORM AL 2135 * o* Cail INDEX TRACING CARD JHM 00776 - | ! ALY LOSIE ype [.a, Li ere ae, ado 4 Or 7 wee Le * ... LE be Ra... eeanare ... ... ......... Zanardi, S. S Lee rza enP. & Russo .: y 0 41- 41- Qe 3838 3838 WK AMA KEY WORD OR CHARACTERISTIC Clinical and radiological problems <a SCOPE NOI concerning asbestosis Italian e Problemi di clinica radiologia dell'asbestosi dell'asbestosi Medicina del Lavoro 63 7-8 257-268 July 1972 Englisabhs PVP eee ee lene ) | One of the most serious problems concerning asbestosis asbestosis is certainly that of early clinical and radiological diagnosis The Authors therefore aim to bring a contribution to the subject by reporting end discussing discusing the semerological findings obtained in nu- 1 merous cases of relatively early asbestous 700 cases of asbestous at first observation found aniong almost 3000 workers workers of the naval industry The clinical aspects consi- dered include subjective symptoms physical physical signs chest ray findings functional and laboratory findings Moreover the availability of a second group of patients followed for a long time 70 asbestosis patients abv~ and periodically contioned for 50 10 1 . years as well as of a thirst group of dead asbestosis cases 32 cases controlled at autopsy enable the Authors to bring a further contribution to the knowledge of the ' clinical course and prognosis of this pneumoconiosis both in its typical evolution and . 1 in the evolution modified by the various complications | + | i geen DATE ~ 4 1ehsy oe j 2 8 : NOIXED BT G ast arr ia sts be rerr SO EDITED Ps ee ee ee go DOCUMENT SO DOCUMENT DOCUMENT TOTAL KEY CODE ZanninDi. Bogetti B. & KEY WORD OR CHARACTERISTIC Ottenga .: PAGE OF 3866 LOCATION SCOPE NOTES The risk and prevention of asbestosis asbestosis in shipyard works Italian Il rischio e laprevenzione dell asbestosi nelle lavorazioni navali La Medicina del Lavoro 63 5-6 221-244 1972 . whet " * Since the first few reports of cases of asbestosis among workers workers engaged in insulation jobs by means of asbestos aboard ships in building or repair the risk of pneu nioconiosis in such workers has revealed so far more and more severe and has in- volved also other groups of workers of the naval industry in whom in the last years pleural or pulmonary lesions are found more and more frequently Of no minor con- cern is the increasing frequency of pleural or pulmonary tumours tumours among the same workers The actual diffusion of such diseases can be related not only to a more sy- stematic medical checkup of the workers but also to the more and more intensive use of asbestos in the last 30 years In fact asbestos is used aboard not only for the insu- lation of engines but also for the thermic and ac^"stic insulation of all ship strictures bath by means of panch and by spray Almost all people working aboard ships in building and repair are therefore exposed to the inhalation of asbestos as it has been demonstrated also by the cases stinked at the Institute of Occupational Medicing in Genoa and by the comumetric findings is therefore required a resoline organization of the preventive measures which consist both ir substituting asbestos with juther mas terials and in reducing the endsent Justiness in using individual indivdual protection measures for the workers directly or indirectly exposed the risk in organizing organizing the work aboard in instructing the personnel in shudying the ambient dustiness TAA Te ee are eet ee ee ee ee) eee eee mee | IHM 00777 . v r = 9 ee oe e ee ees em eee ee, JHM 00778 Project No. 6 - The cellular basis of the biological effects of asbestos Study of morphological and biochemical changes of macrophages and fibroblasts cultured in vitro in the presence of well defined particles of asbestos such as chrysotile amosite crocidolite anthophyllite tridimite and in each of them long fibres and very finely divided particles separately Whenever indicated the in vitro experiments to be expanded by suitable studies on experimental animals Dr. Benvenuto Pernis M.D. Universit^ degli studi di Genova Via Balbi 5 Genoa Italy Cost 45,000 JHM 00779 cr ceeltho sh gp pbs it, et fe cg ds ee ryury MOL Ae yr MED BT PAGE 14364 DOCUMAN y = Governa KET CODE M. & Pernis .: KEY WORD OR CHARACTERISTIC oSn or NO ws NO DOCUMENT 3862 _ LOCATION LOCATION SCOPE NOTES 20 Biological effects of asbestos It Azioni biologiche dell'amianto 27 La Medicina del Lavoro 63 5-6 161-178 1972 36 69 . English abs PVP 72 4. 73 85 = Vly eves}a eo DATE . a DOCUNS DOCUNS TITLE KEY CODE 21 ca 6 0 1 Ef INDEXED BY eas 6G MS NUMBER a oe NUMBER DOCUMENT NUMBENUMRBER EDITED OT . PAGE OF 84 DOCUMENT AD 35 LOCATION Governa M. & Rosanda .: KEY WORD OR CHARACTERISTIC SCOPE NOTES A histochemical study of the asbestos | 20 body coating 85 Brit I. Industr Med 29 154-159 1972 Governa M. and + Rosanda C. 1972 Brit J. industr Med 29 154-159 A histochemical of the asbestos body coating Asbestos bodies after iron extraction were tested by _-- stud- y | methods for mucopolysaccharides The results of the reactions suggest that histochemical . ' in the coating of most bodies During the formation acid mucopolysaccharides are present matrix for iron deposition on the of the bodies acid mucopolysaccharides might act as a | coating ; S ae F44319 BLIES 911 th 11 111 INDEX TRACING CARD JHM 00780 waltie aos id, " volt IMULSIU IMULSIU ST oe 4 KUMEN ya Governa M. tbr $n i, at an 3r sfr Tene . ...bea nee efOTUNT NTmE ......... & Rosanda .: eka PAGE vdeo ale of is 1 DOCUMENT 3863 LOCATION FET CODE . KEY WORD OR CHARACTERISTIC The mechanism of formation of asbestos bodies Italian Meccanismo di formazione dei corpuscoli dell asbesto La Medicina del Lavoro 63 179-188 1972 5-6 From the results of the most recent studies on the mechanisms of formation of asbestos bodies it seems that one can conclude according to SUZUKY and Chung 1969 that asbestos bodies are the terminal product a biological process which ^beursin the macrophage which has phagocytosed a mineral fiber within the phapo- tysosome the fiber would be covered with the coating of organie substances In this report the results are presented of a series of experimental studies from which it is possible to propose an alternative mechanism of asbestos hodies formation By an in vuro experiment in an acellular system previous observations have been confirmed according to which the formation nasbesins bod 44 postible without the active intervention of cells in fact asbestos bodies have been obtained by incubating chrysotile fibers in sterile satine solution containing albumun hyaluronic acid and ferritin By histochemical studies on the coating of human asbesios bodies it has been de- monstrated that the inner layer is composed by proteins mixed with haematoidin and ferrie iron above this there is hyaluronic acid finally covered by an outer layer containing ferric iron Histochemical studies on the substances which deposit themselves on the asbestos present in experimental granulomata from carrageenan have demonstrated the high affinity of asbestos forhaematoidini haematoidini hyaluronic acid and iron In fact already in the initial phases of granulation tissue formation all these substances had stratified them selves on ashestos fibers These were coated even though they were free in the tissue ground substance and were not phagocytosed within the macrophages : Hyaluronic acid is a physiological extracellular component of the gound substance t crophages matory the tosed core ; dies cel sby of the is the rich In lung One in can in of ts be the the in the acid intersktnim can found proces the intracelur thenislve conlusion conetiv conetiv therfore ground shorterfibers mucoplysachridesifintersktnim is free in tisue tisue microphages ocuring one one even the Haematoiche ETE asbetos sugest would completly can keps even mucoplysahride subtance completely in the intersum Haemtoicheconetiv budiesgive of phagocytosed hypothesis sugest without and mind tisue rise hypothesi whileto two that that the as is a EE dlso conetiv the a phagocytsed EPP ground by theintienrtevrevennttiioonnthat substance mechanismhaemt~-nd intervion consequc asbetostisure longer ofsubstance mebrane asbetos subtance EEE bodiesfibers of can of past in macrophges usaly whichwhich be of macrophages bodies macrophages areas formation ETT alveolar are are would of found macrophages might haemorges xtracelur formednot within be where E an macrophages phagocy-repsent asbetos PrP outside thebo- mt1h3-e ifounnd intam- tirooonpresnt * x , . weet} Lahe@ pathy <a Br16 UMENT BITLE , ALY CODE 21 73 85 . < 9 s [> F INDEXED ST faye gt gt 1 ube Se nt G < WY /STRAC NC Lat Lat cde > 69s DOCUMENT NUMBER EDITED BY . Governa M. Vadala C. Rosanda KET WORD OR CHARACTERISTIC ee cr > e2a abe ete t fA 2 PAGE DOCUMENT 40 OF 3785 LOCATION SCOPE NOTES Histochemical demonstration of hematoidin in the innermost layers of human asbestos body coating Int Arch Arbeitsmed 30 4 273-282 1972 Summary The known histochemical reactivity of asbestur bodies has been treatment modified by with sron extracting solut sons and enzymes Asbestos bodies did not exhibit any bure Prussian blue paritesity paritesity alts treatment treatment with iron extract- avidi ing solutions but showirl a tuludme blue metavleruma adu^to hyaluronie The satir lokines teratesh delate with irun temayng solutiotis and digested with suurtaclitematic negative testicular by abutonulase were not teluiline lilie suurtaclitematic fait exhibited ^ againa Perls pussitivity Then these kimi ladies becaine ngai Perls after a second nun extraction niil showed instead a pussitive hern^to~-l~-tnraction The apywareik juogissively diameter of the same body apywareik smaller after each treatnient Moreover the hematoidin positive layer tail l^en su digested by trypsin that asbestos , fibres were at least optically risked costing | These findings suggest that during the development development of asbestos badly costing first gostems gostems hematoulin stud letrar uvis are dejaisited dejaisited dejaisited user nakustive lebron muka sonjacatly hyaluronte hyaluronte weid is laul stunned tla t^...rk laver sud finally oiler oiler fearic Int sonjacatly is etiches sonjacatly issetiches issetiches impreguate impreguate the kyabqueen kyabqueen acel acel moden moden colon sees rr . cove a T mmm ee eee eee IHM00781 . te er - es oe _ ee: ^' w . v0 tae " a . a = DASI VOLUMENE THILL ca if, if. SE aS 2 ee ee ody " ade of2 SHET LEMEME KUMITH a2) a eee) re PAGE or tad Governa Vadal^ KEY CODE Histochemical M. & Vadal^ Rosanda KEY WORD OR CHAHACTLHISTIC 43 Histochemical study of asbestos fibre LOCATION SCOPE NOTES ~ 24 coating in experimental carrageenin 28 72 granulomas British J. : Industr Med 30 3 248-252 1973 85 : nn) a] To study the composition ofasbestos body coating asbestos particles carrageenin granulomas were tested histochemically for present in experimental ferrous iron haemoglobin and haematoidin The mucnpolysrechur.des stains ferric and sections both untreated and treated with were applied on microscopical "1_ results indicate that extracting solutions and enzymes The fiyaluronic acid asbestos is rapidly coated with haematoiain ferric iron and Seen r t - aan tae bap ae A . - 4 ' Ne ee +, . en ae ea ett as DATE INDERED BY i * DOCUMENT AW o> : * Parazzi + KEY CODE COITED . Elena Pernis .; KEY WORD OR CHARACTERISTIC Secchi 43 Studies on in vitro 44 cytotoxicity of asbestos dusts del LaMedici Lan voa ro 59 10 561- . 576 Oct. 1968 G.C. DOCUMENT NO PAGE or 3140 LOCATION & Vigliani E.C SCOPE NOTES Also Proceedings Conf on Biological Interna Interna EffectsEffects 561- of Asbestos Dresden April 1968 published 197 PP 74-81 . The cytotoxic action of different types of asbestos dusts mee phages cultured in vitro was studied This on guinea pig micro- the production of lactic acid the lots of was done through investigation of | culture medium of Nuorochromasia and the release into the - and lysosomes lysosomes enzymes betonging to different intracellular structures -- + from cytoplasma and crocidolite dusts macrophages The cultured in vitro and treated with chrysotile <a both types of asbestos results obtained using the three methods listed show that is evidenced possess a marked estotoxic action for macrophages this action loss of by a reduced production Nuorochronesis of lactic acid in the treated cultures by a rapid of lactate in the cells and by a marked release in the culture medium of the dehydrogenase cells Crocidokite which is an enzyme belongbelonginging to th cytoplasmatiz fraction | un even exerts a more marked cytotoxic action th"flnchrysotile and preater action than tridymite dust used as a compirisun compirisun Experiments made using separately the particulat and fibrous fractions of the above mentioned types of asbestos showed a high toxicity of the fibrous fraction two a moderate damiging action of the particulate fraction the different and the macrophages of the two types of asbestos ured in this toxicities for |op be attributed to a greater richness in fibres of the investigation might therefore of these fibres treatment of the erazidolite or to some properises reduce the asbestos dusts with PVPNO or EDITA did not estolovi~ action the authors ate therefore inclined to believe that the |a cwyittohtotxhiec cahcetimoincails cchoanrnaecctteeridstwiictsh the physical characteristics of the dusts rather than BIIIJune 1969 1+ LS eT) wrmre deem or 10 JHM JHM 00782 ene oe - . a eoef , els DATE , by : $3 ' (ef 1 ads 1 } ' as =r HO~ UMEME INDIGED LUIFLO DOCUMENT SALE KEY COOL 120 P^razzi P^razzi Secchi P^razzi .;.; Secchi Pernis G.C Pernis B. & Studies Studies KEY WORD OR CHARACTERISTIC on the Cytotoxic Action of 12, |, PAGE Vigliani aseia -- -- .: a ^ DOCUMENNOT 3087 LOCATION LOCATION SCOPE NOTES 40 Silica Dusts Dusts in Summary Dusts on Macrophages in Vitro 72 Arch Environ Health 17 850-859 , Experiments were performed in order 7 85 Dec. 1968 investigate the site of cellular damage . 91 duced by silica particles in vibo to peritor al guinea pig macrophages macrophages The release into the culture medium cell sap enzymes lactate and aldolase and - GHIJKL AUTOEX 1992 MOLE FORM 1138 the deliydrogenase umal unzymes ac phosphatve and rikonidense as indicate of lesions to different cellular structures v followed Loss of fluorochretaasia from ed as evidence of damage in the till^,be till^,be ma brane was also studied with this method is possible to elucidate the early me fications of macrophages treated with sili particles When the interaction between quartz s tive groups and the cellular membrane w prevented by coating the particks with s rum a delayed release of enzyines was c served These observations suggest that when s ea is added to nazcrophage cultures in viti it interacts with the external cellular met ~ brang and that the first cellular ksion o201 at this site Further dainage might then * inflicted by the liberation of lystsomal, ,, zymes TRACING CARD sees IHM 00783 been hu t sad |! pe ome , et, .< IMOLA U IMOLA U 67 . sh H = . $e rte ovae teres cory lone hein, a} o MENOIRD ary = me riede a], ety Sey seems 5 Bes PAGE of 4 La = 6 MU 3507 KET CODE 44 72 Pernis B. & Castano .: KEY WORD OR CHARACTERISTIC CHARACTERISTIC The effect of asbestos on cells in vitro Effetto dell'asbesto sulle cellule in vitro It LOCATION NOTES -- Medicina del Lavoro 62 8-9 120-129 120-129 74 Feb March 1971 - B 111-2 111-2 English abstract PVP Experiments have been carried out to investigate the effect of different asbestos dusts erocidolite and chrysottle on long term cultures more than 6 weeks of mouse peritoneal macrophages Some cultures were treated with ferritin with the aim of te- sting the possible formation of asbestos bodies in vitro Finally trials with silica in the same culture conditions have been made as controls The preliminary results indicate that in optimal culture conditions asbestos is not cytotoxic Such data are discussed with reference to the contrasting results previously obtained and to the effect of silica More More oe More More ona the problem of the effect of asperne in viro and the problem of asbestos body formation is briefly discussed Le ilk @afitlr BATC DOCUMENT DOCUMENT TITLE KEY CODE 72 44 srk |, DOCUMENT if, INDEXED AT aay > 463. 4a eee Se ee 4 ofa DOCUMENT NUNUMMPERPENUMPERR e2y ote 4 EDITED BY Pa DOCUMENT NO Pernis Vitro Efects & Vigliani Vigliani Vigliani Vigliani Vigliani .: KEY WORD OR CHARACTERISTIC and In Vivo Studies of Asbestos Fibres on : on the Macro- PAGE OF 2981 LOCATION LOCATION SCOPE NOTES 45 Lecture 17-2nd Internat Conf Bio 40 Effects Asbestos Dresden April 1968 120 85 em wee ee oo we eee IHM 00785 Project No. 7 - Anthophyllite asbestosis in Finland 1. 1. Clinical picture of anthophyllite asbestosis fibrosis ed, of the lungs to be investigated in a cohort of past and present workers of Finnish anthophyllite mines and mills Diferences from the classical asbestosis in radiological picture speed of development frequency of simultaneous findings of pulmonary fibrosis of death etc. to be explored with pleural plaques cause 2 Prevalence of pleural plaques and calcifications in the general population to be investigated in correlation with the environmental conditions 3 Prevalence of all signs of asbestos exposure to be investigated in a cohort of construction workers Dr. Leo Noro M.D. Institute of Occupational Haartmaninkatu 1 Helsinki 25 Finland Health Cost 42,000 JHM 00786  . ' vei " F ; Gra11 1 we me wre toe DONT DONT HILL [ee rah ine eee Ls S. TT Rs AD mere cree tea m a Ahn lmAhlaman n mas , .: svt ... ... ...... ste 1 PO eer TORT wears eeceree. wu PAGE or 3779 7 To Locating KIT KIT LODE . oe. KEY WOUD ON CHARAT 11 HISTIC -- Industrial 40 Industrial Industrial pulmonary discase in Finland 84_f Scand Resp Diseases Suppl 63 101-104 SCOPE MOTLS 1968 4 wwe = eee[ils 1 DATE DATE INDERED BY > 6S) it, 47 DOCUMENT 43, i, 2 1 ats 1 _ DOCUMENT DOCUMENT KUMOLP f . yf.. EDITED ST _ DOCUMENT no sae atames oF DOCUM r79 PAGE or 3500 3500 B.Siltanen KET CODE KEY WORD OR CHARACTERISTIC SCOPE NOTES insulation _asb|e_sastbeostsos Environment B 1-5 1971 summary me meee 44 nnn 7 No a INDEX TRACING LARD Ahlman .; Partanen T.J Rintala E. & Viikeri .: Anthophyllite mining and milling as a cause of asbestosis Paper No. 25 Conference on Biological Effects of Asbestos Lyon October 2-5 1972 Summary Clinical and epidemiological experiences concerning occupational exposures to antophyllite asbestos are reported The data base is a cohort of 1 249 individuals with an exposure at an antophyllite mine and mill since 1936 and 105 known cases of asbestosis among them Results and progress of different phases of the project are illustrated and discussed A pic- ture of a dangerous working environment arises with_ heavy health risks especially in workers with longlasting exposures JHM 00788 : 2 2 : 2 > - " | DOCUMENT ETEL . - " - - rf 1 ade - - KUMBEIE - - KUMBEIE - nS bl PAGE ioe PAGE OF TYE 31001 10LATION Laamanen Arvo KEY CODE 1 3 KEY WORD OR CHARACTERISTIC The use of studies snow samples in air pollution SCOPE NOTES 84 Environment 42-50 1968 76 | In one investigation of air pollution in lin land we have measured the distribution of p different impurities in the environment of J somer point and area sources by primarily using the snow sampling method The -now Psampling avthat is easily appdicalde in esti- mating sleposit levels and is especially useful in sparselspyarsely populated areas although we have demonstrated that under circumstances circumstances where there are similar criteria for evaluations we tn can also use the in thel that we have developed in densely populated areas as well 0 fowls ie 0 ec f DATE IA. . INDEXED ST DOCUMENT T1768 eg G " bees 3 Laamanen Arvo DOCUMENT dean ah H cele DOCUMENT DOCUMENT BUMPER BUMPER _ EDITED T PAGE ofa os a DOCUMENT 97 OF 3650 LOCATION KEY CODE KEY WORD OR CHARACTERISTIC SCOPE NOTES 1 Calcium Calcium Calcium magnesium iodide iodide 8 chloride sulphate and nitrate concentrations 56 in drinking water in the surroundings of 60 an asbestos quarry a 48 Report from the Institute of Occupational Health Helsinki 84 No. 72 5 pages 1 fig 7 tables March 1972 w purculated.16.2 purculpuraculatted.16e.2 d) .16.2 ) LOA * * ee eee ee es + ele pe rcwmmne amerwes = ee eee Ci 2 oh IM TRACING TRACING LARI SKAY 00789  ppetde . |} bdaese pate , 11 [irene or 1 theses eed _ gees ce a A amet ... DOCUNAK 11906 Laamanen Arvo KIT COUL KEY WORD ON CHARACTERISTIC reli y/ ... det ... ... InLumini re T ...... ...... ...... 0 InLuminii InLumini InLumini T 01 ree FAGS LOCATION NOTES 6 Insfrt om i thet Inu stit tue te Occupational 5 Health Helsinki Finland No. 72 fig 5_pages under 5_pages No. LA c a |p RALp_tpeleAe 2 under under 56 1972 305 March .. . 305 , 60 47 47 nN * - en :: DATE S D INDEXED 9 , fas 1 433 wl, i COITED BY | AE 1 1 22g DOCUMEST PAGE cle OF it So DOCUMENT NO 2947 LOCATION DOCUMENT Tete * KEY CODE Meurman L. & Kiviluoto KEY WORD OR CHARACTERISTIC .: SCOPE NOTES 36 Retrospective prospective study of 37 anthophyllite asbestos workers in Finland Effects 48 Lecture 34-2nd Int Conf Bio t Proceedings 70 | Asbestos Dresden April 1968 of Finnish 84 The The mortality mortality from all causes of Finnish Proceedings Proceedings asbestos published PP.135-23 == m=i| ners is briefly discussed 60 woisee International Similar paper presented at International Conf on Pneumoconiosis Johannesburg S.A. April This very brief paper presents presents refined data similar | to that presented by the same authors authors at Dresden is in 1968. The mortality mortality rate from lung cancer is 3-5 times higher than the expected but the authors note that incidence of G^ cancer is normal pointedly of mesothelioma and there were no cases JohannesburgJohannesburg PROCEEDINGS._PRpOCEDIrNGS._pr 190-191 in 1970 ees oe afer me et cere ame erm nt te en ene ee cee ee Oe oe Sd INDEX TRACING TRACING TRACING CARD ae . ... . ve : INDEXEO INDEXEO INDEXEO 6 . ' oe. HT DOCUMENT 1466 Noro Sears tee Leo jonas tei, 1 | , il, treed pega _ a = ae HT ted Nourt see mee oe ord oe m SB tea SHELL IAGE 2887 IAGE atnig aad a inst GMMENT of 2887 KEY CODE KEY WOND OR CHARACTERISTIC CHARACTERISTIC 0 Occupational and occupational Asbestosis Finland Amer Industrial Hygiene Assoc J. = SCOPE NOTES 10 195-201 June 1968 331 1 ee vn eee - -. ee _ ~ - i Ideas t a ste fA 8 < 6 ' < fF G Hy / INDERED UT 683 ' edn EDITED OT ( ty 3a Ab COCUMENT SUMMER a2) i|, ole 4 DOCUMENT DOCUMENT 10 DOCUMENT TITLE \ ap ' " Noro KEY CODE wr L. KEY WORD OR CHARACTERISTIC PAGE OF 3216 LOCATION SCOPE NOTES 30 Epidemiology of Asbestos Related Disease = Presenat t ed Internat 36 Congress on Occup Hlth Tokyo Sept. 1969 38 | _Proceedings published pp 207-209 84 1971 + In some thousands of operations and jobs - the workers are exposed to asbestos dust Facts concerning the health effects in the mining and asbestos industries MM are well known but other occupational groups have not yet been studied enough cases Improved dust control has diminished the number of classical asbestosis } but the late results such as malignant tumors have entered into the focus of research Smoking the increasing amount of air pollutants and other potential environmental carcinogenic agents however complicate epidemiological studies pinong workers and the general population exposed to small amounts of asbestos ee ee ee dee ee em ee. wm- o __ x ha ee ee ec ee os oe wes eee ewe: - le wee ee Cor Soho | J JHM 00791 ewe Te BTS ee SRS TIS Sl tS eet = a 4. ro DATI 6 tae LASTE KETE Hee ke te -- FRIED oo. WON ee ee oT es ee een Paes os be. eee es HOCHMENT HOCHMENT N . DOCUMENT DOCUMENT teke PAKE or 2560 / lloro KLY CODI Leo Ahlman Kaj Laamanen = KEY WORD DIE CHARACTERISTIC Arvo E Vikeri .: LOCATION LOCATION LOCATION SSS eee SCOPE NO10 Asbestose als Berufskrankheit in 48 Einnland . 57- Gewerbepathologie und Gewerbehygiene 22 179-184 1966 , 53 84 HUI Zusammenfassung Die Produktion von Auflugby Ilit Ashest in Finnland liegt gegenw^/rtigbei 1500 im Jah~-rMehr als 1200 Arbeiter sind beruflich Ashest staub ausgesetazusgetsetzt Zus^/tzl~-rl~z-u technischer Staubverfuiting s^>mi zu den Jetzten 10 Jaben verst^/rkt medizinische Arbeitsuntersuchungen durchs gef^...hrt worden und ungef^/hr4000 R^ntgenaufnahmenin Verbindung mit periodischen Untersuchungen gefertigt worden Bis jetzt wurden 193 Asbestosef^/lleim Verlaufe von 30 Jaluen diagnostiziert DTS davon in der Asbestindustrie und 35 unter Isolierern In der Asbestindustri lag die Zeit die die Arbeiter dem Asheststanli ausgesetzt waren un 69 F^/llen zwischen 2 mul t^ Jahren und in 49 F^/llen bei weniger as 11 JahreInn der zuletzt erw^/hnten Besch^/ftigungarheiteten & Par sonen l^/nger als 35 Jahre ohue Pneumokomiose zu bekommen Die Situation fordert mehr Aufmerksamkeit in bezug auf die technische und medizinische Kontrolle in Ashestwerken Q A DiOCUMENT DAIL a INDEXED BY H > a$4 el, - ede H 127 127 ili EDITED BY KUMBER DOCUMENT TITLE PAGE KEY COOL 70 48 Yu ov _10 12 31 * Noro Rintala and al KEY WORD OR CHARACTERISTIC MANUSCRIPT not published CONFIDENTIAL amthopoh f y aml tholphi ylt lie te asbestosis Prelinary results 1967 }ye Lecture Dresden published 1973 Conference pp 130-135 Proceedings -- estas OF / IDOCUMENT NO 2726 LOCATION , SCOPE NOTES 7 -13- -34 84 ~~~ The Institute of Occupational Health has until in the asbestos now collected in Finland 144 ceses of cabestos industry - insulators excluded Industrial hygiene studies from show that the dust exposure has been rather recent years mill but the situation heavy in some jobo especially in the quarry and is improving During the last 30 years exposed to anthophyllite sobestos in the approx 320 workers have been quarry and mill during more than one year One half retired workers total 135 of which 12 were new ray being in stage 0 - I 12 in been diagnosed in 1/4 111 present workers and 24 have been studied roentgenologically and clinically In 37 cases changed indicating occupational asbestosie have been I 5 in II and 2 in III found 18 In we. the aubestosis phle^ cases the age exposure history of smoking pneumococionis production of a shortness of breath and abnormal lung function testa in the nobestouia were significally greater than Compering ` breath with the ordinagrryoumpale rural poptuhleatrieonpaonrd ted symptoms phlegm and shortness of symptoma were lumberjacks at the enne age theso , more frequent among workere exposed to sabcatos dust The with more detailed ray and ultrasonic study is continuing Coen mm ee fg ee ee ey a echograph and other examinations wee HM HM we examinations -: See ie a oe wee. ... mmm - ee cen = st emer oe -- ee wee | 00792 . pin . oe ' wily if ~ matte WATE { t Df " Jom21o0 #T oe tele te 1 ' aan = pe ere FOFILO 6 aye resect: Rives KEY CODE Nurminen Nurminen ia Markku KEY WORD OR CHARACTEHISTIC ...... ...... 36 study of the mortality of workers 37 in anthophyllite asbestos factory 38 in Finland rfsiate ... ee ... are ee. DOLUMENT43 DOLUMENT43 PAGE OF 3789 40661104 SCOPE NOTI Environment 9 112-118 1972 : 48 a JL - " ee ee 60 ~ Nurmimen M environm 9 1972 112 70 workers in an authophyllite asbestos 118A study of the mortality of wn factury in Finland workers workers employed at an anthophyllite anthophyllite asbestas A cohort study of 1030 84 the information about asbestos related mining factory is described disease Ji extends available only for workers with at this factory which was previously ea the workers with severe exposure The cohort was defined as a minimum exposure of three months who had started ment at any time between 19J6 and 1966 and the employ up to t- he - end of 1968. The hazards of main analysis was of mortality . indicated by the main results of this exposure to anthophyllite asbestos dust are w _ was found to have morta ty study 1. The cohort of workers bronchus and excess overall mortality accounted for by cancer of the lung trachea respiratory tuberculosis and other 2. Asbestosis as an underlying or contributing cause was respiratory discoset c. ertificate of every fifth deceased member of the mentioned on the death lung cancer among onthophyllite three months was in asbestos cohort 3. The mortality from workers with a minimum exposure of expected certain dge groups over three times that A r i ~~ - - - -.eE = - - ods wf; a4 sa ofr 46$a sf fs |, Sosa le < oe Ff 6 # 3 she 23s sft COCUMENT AUMUER 2? edn COCUMENT AUMUER t~ DATE IADEREO GT EDITED OT DOCUMENT DOCUMENT AC AC DOCUMLAT VITLE Siltanen * Siltanen Eero PAGE . OF 2957 LOCATION KEY CODE 3 84 KEY WORD OR CHARACTERISTIC Measurement of asbestos dust Nordisk Arbeidsmedisinsk M^te P^ Fagernes 28 - 30.11.1968 pp 1-2 SCOPE NOTES Seto mee fame ne. a om 7 foe Ce ee Oe ey oom = ss a ee eo ae ee ee ere Poe om JHM JHM om JHM we - ee JHM el 00793 _ . . ee ee Ce ed . ~ oe  - ... -... ... ... ...... ... ... ...... ... ... ... ... - -... ... ...... ... ... ... ... - ......... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ......... ... ... ...... ...... ... ... ... ... ... ... ... ... Ti-lkk ... ... ...... ... ... ... 1 ... ...... ... ... ... ... ... ... ......... ...... ......... ... ... ......... / - / - ... / - ... ......... ...Oe ... ...... -... ... ...-... ... ... ... - ... ... ... ... ... - ... 01 - . 3409 ... KEY COVE ee Siltanen Ecro Wee WS oe renee peo KEY WORD OIL CHANAE FRIASTIC FRIASTIC Stas PS Eat? H , ear TiS ee SCOPE KON ee, 3 43 m_a | ss me 44 eel Comparison of asbestos dustmeasurements by counting counting particle and concentrations massconcentrations concentrations with different 45 _} methods Gen __ _48_ Vergleich einiger Methoden Massen - 60 und teilchenkonzentrationsbestimung teilchenkonzentrationsbestimung 61 der messung asbeststaub a a oe eee - Staub 76 Reinhalt - Luft 436-439 -Oct 170 English abstract H. Bohlig & Pelnar -"- 84 __ r . DATE TT DATE _ 4 Cee ea Le INDEXED ST ae 7 TG 4$3 ars ae $43 EDITED BY | -~--t~ a DOCUMENT a2, - |, ~ mw ~-nee eters x DOCUMENT I DOCUMENT Taskinen PAGE OF 3885 , K YCODE 25 Taskinen Eero Ahlman Kaj Kaj Wiikeri Wiikeri & Wiikeri KEY WORD OR CHARACTERISTIC Current hypothesis of the lymphatic Matti Matti LOCATION SCOPE NOTES 29 40 73 transport | Chest 64 of inspired dust to the 2 193-196 , Aug. 1973 parietal parietl pleura 84 eee ~ en mm _ _ ena. - In the light of a case report we will describe a hypothesis hypothesis of the lymphatic lymphatic otfransport mechanism of inhaled dust particles to the parietal pleura The autopsy a molder who had been employed for 41 years in iron foundries showed mixed pneumoconiosis In the heavy parietal pleura there were black lingar streaks afaollowing the course of intereostal arteries These formations were cally interpreted interpreted as periaaterial lymphangitis and fibrosis caused bymictrheosdeunsgti According to our hypothesis hypothesis the dust partiel ^ have been transported from the lungs via the lymphatic lymphatic vessels partly in retrogression The mechanism is posed to be the same in the transport of small asbestos slip- plaques particles causing pleural wes ane on see ee > meee tw ewe - ro Wee oe dee ewe vote ee emo INDIA THACING CARD JHM 00794 a2e ody J) Veg COTS md Datt ~ 01 DOSUNIKE DITEL om Soe KEY WOUD OR CHARACTERISTIC CHARACTERISTIC CHARACTERISTIC CHARACTERISTIC Ultrasound Examination of Pleural Plaques _experimental _experimental _experimental patholoric studies Suppleme3 n301 0t1301 to Acta to oe Radiologica L 62pp Discussion of May 1970 Helsinki Circulated Front page 55 andpacespaces and 56 3359 ker AT40 AT40 000. |Poe # DAIL aoe |; bot rr MAGIXED BY Ts PT | A Smee aot 4 6 mf e$e of: sty 63. sho 622 4 U BOMC ELT wd EDITED LT DAC tT VT KEY CODE PAGE ViikerMi. J^/^/skel^/ineJ.n & T^/htie KEY WORD OR CHARACTERISTIC Ultrasonic Examination of Pleural Thickenings_and_Calcifications in Occupational Asbestosis Dis Chest 17-2J0 uly 1968 ali 3 DOCUMENT LOCATION SCOPE NOTES we eee The roentgenologie diagnosis of occupational asbestosis is based upon typical pulmonary fibrosis and anteriorly detected pleural calcifications which appear nivel kater than parenchymal parenchymal changes Therefore a definite diagnisis usually demands a ling observation period We used ultrasonic A. and B. + mode methods to examine pleural changes in nine occupational asbestasie patients and five normal persons ^ n normal persons the parietal pleura was shown as thin sharp line when the Beurode method of examination was used Roentgenographically observed calcifications were easily detected and distins guished from the normal pleura by this examinations It is noteworthy that sinis far echo peaks were seen in mode examinations in lateral and posterior pleura where roentgenograms did not reveal pleural calcifications and their size could be traced well with the mode examination Thus it is possible in find early pleural elanges which in our opinion are connected connected with necupa fional asbestosis Diagnosis could he made carlier without a long observation observation time time se ew ed rere sw prers eee ' ne eed | rem a es ee eee fw te oe twee mrere mes eee es cee ee fem ee oP - rt 0 eee. . - / = . .. wm am eetrcwmes a | oc cee .. + tame meee . 0 me ee ee tae see wie Oem ees om am ermemate te meee ee es e ee ee ee . 8 mmmmcc mmm 6s te wt oe te mes se ees emmen omens | mee ees one < am ees. wee tm tek ees ore e" ee me ne +o cece ee ee oe . - me fe cee ems ewe we meme oe rn De ee ee me me ee ee eee ee memes oe Litter 400144 ' - 611414 611414 oe oe SDE TRACI ( ARD Mem ve memes 8 eee JHM oe 00795 , once 0416 ofr 4 8 oa it, < pw e@ ft INDLAED BY aoe afer G6 Wf aSe if, ede COULD BY ,|, dr adr ...H UMKI ...K a2 it, DOCUMENT title KEY CODE 12 30 31 PAGE * Viikeri .; J^/^/skel^/ineJ.n & T^/hti .: KEY WORD OR CHARACTERISTIC Ultrasonic examination in Occupational Asbestosis Scand J. clin Lab Invest 21 Suppl 101 105 1968 eleoo OF ve _ DOCUMENT NO 3036 LOCATION SCOPE NOTES Wi Gizi Wi Wi Gizi Wi Wi Wi Wi Wi Wi Wi Wi Wi Wi Wi DATE INDEXED T Wi Wi Wi EDITED V Wi Wi Wi DOCUMENT NUMBER Wi Wi DOCUMENT TITLE PAGE KEY CODE Viikeri .; J^/^/skel^/ineJ.n & T^/hti.: KEY WORD OR CHARACTERISTIC 12 Early detection of cal3c 0 ifi aanc nda d tccalcifi icaations o lcalccn ifiicas tfionsications 31 ultra sound pleural thickenings determined by 76 Environment 5 68-72 1968 84 Wi OF Wi } Y/Y DOCDUOCUMENT MDOECUNMETNT NO 3089 LOCATION SCOPE NOTES Ht SUMMARY . The thoracic wall of ten asbestosis was examined by ultp rasonie and pmatoiedne ts examinations to determine the existence of ; pleural calcifications and thickenings Roents Enea: ceeeed genographically observed calcifications were found in seven patients In the ultrasonie examinations distinct changes changes were ^...bserved at these plans In addition pleural pleural thickens pm sal inge were recizn^>alsu posterioch where they had not been seen in the fortilgenveztanto fortilgenveztanto Ultrasonic Ultrasonic examinations cem to offer pulssj Lilities for improving improving the early diagnosis of pleural changes _ _ ms HO 7! ees " ssw Ps - ew - OD OE tLe I = rere eae INDEX TRACING CARD = THAT THAT 00790 - 00790 |. JHM JHM 00797 id, V4 eT Pia _ Project No. 8 - A study of the health effects related to asbestos exposure in workers of the industry . and other residents of New Orleans Phase I All employees of a Manville plant and National Gypsum plant manufacturing asbestos goods to be examined by a questionnaire on occupational and respiratory history by a physical examination by PA and two oblique chest rays and by spirometry and transfer factor measurements Additional physiological measurements to be done in those with abnormal clinical or radiological findings employees to be traced and the cause of death to be investigated in those who died Attempts to be made to assess the past dust exposure and current measurement done in the plants to be utilized Phase II Plans for community investigation of risk of malignancy in individuals outside the plants to be prepared during the first year for the later realization Cost 291 380 Dr. Hans Weill M.D. & Continues as IOEH # 16 Dr. Morton Ziskind M.D. Tulane Medical School - Section of Pulmonary Diseases New Orleans Louisiana JHM 00798 Enterline Philip E. & Weill Hans Asbestosis in asbestos cement workers Paper No 28 Conference on Biological Effects of Asbestos Lyon October 2-5 1972 Summary The asbestos cement industry consumes the bulk of the world's output of asbestos Workers in this industry are exposed to silica and and y asbestos and develop both asbestosis and silicosis - with the amount related to their total dust exposure It is estimated that radiographic changes of 2/1 category or above appear after a total dust exposure of 1,000 months Asbestosis appears to be less of a problem than in other asbestos products industries possibly because the asbestos cement industry is growing more rapidly and it's work force has had less dust exposure Both chrysotile and crocidolite asbestos are used with the latter confined almost entirely to asbestos cement pipe Ce- ment pipe workers appear to have a great excess in respiratory cancer but little asbestosis whereas other cement workers have a modest ex- cess in respiratory cancer but a considerable amount of asbestosis JHM 00799 i Ff , Geen], " f . ame len's w tfone DATI trees soeoega ebb eee comes iL. ober |. ... 1 vc mee mace Tre Vee teet PT od, ... Seems ... See aenedl ... ed lait J ... 3406 3406 . ia BOLUMENT BOLUMENT BAILE SET KEY SATH 1 * * Waggenspack Carmel Serr Tee Waggenspack RI TLS eT r mO eee. on S PEP . KEY WORD THE BLANADIIHISTIC BLANADIHISTIC BLANADIIHISTIC PAGE Ss 01 -- LED & RAIN 2S at ee rd SCOM NUTES of former A mortality study 70 of two asbestos employees products manufacturing manufacturing - companies : 80 Proposal for doctoral dissertation submitted to Dept. Epidemiology Tulane Univ.July 1973 32 pp ; \ = t fenu |!I > @o ooci "| ried: oe TF BAYC FINDERED BT ol DOCUMENT TITLE Weill * Weill # KEY CODE Th A =" _ Sa te ts , te ^' i i 1 5 4 3 aE DO~ UM~ N^ KUMMER EDITED Hans KEY WORD OR CHARACTERISTIC Pulm|oPn ula mor nay ry function testing in industry 76 J. Occup Medicine 15 9 693-699 Se|pSet pt. . 1973 : te te ZEKE SEE PAGE T! tye ; DOCUMENT NO OF 3925 LOCATION SCOPE NOTES . . ~ . ~ . Teme es J 7 ee - TO oem Ot aie a 2 ae Suminary on. 7 of . a. As a result of the increasing number of demonstrated or potential occupational inhalant exposures which may adversely affect lung function tests to delegi im- paired pulmonary function should become a part of the health surveillance program in many industries In order to funther this objective I have tried to provide some answers to the questione What must the pulmonary function test do and what will it tell us How can we extend the information obtained from simple spirometry ? What additional tests should be considered Who should form the tests and with what equipment What are the problems in analysis and interpretation of results And tnally under what circuinstances might inkilation provocative testing and development development of a molite function unit be considered ; : ee MaliqueM N alique ENL INDEX TRACING CARD JHM 00800 00800 12 Re oo ' 1 - Tm e 48 1 eo om ee ew tom rts ai fees oe we SEE oe ee fet ree adn at oo et ee 1 igs cae [ee _ ow soe qe BIGHLIAMEBNIGHLITAMENT DILL Weill H. Wangenspack C. Bailey W. 0 Radiographic andphysiologic patterns 40 - among workers engaged in manufacture 42 ofasbestos cement products 43 - J. Occup Med 15 3 248-252March 44 12 13 62 70 80 tam trees et tt or , M. & 3797 Rossiter Rossiter = 13:112 Be JHM 00801 JRMoog02 Project No. 9 - Monograph The Health Problems of Asbestos Preparation of the manuscript of a new book entitled The Health Problems of Asbestos Cost 3,291 Dr. John Beattie Professor oc. Ash Tree House Swavesey . Cambridgeshire England Not yet published JHM 00803 , JHM 00804 Project No. 10 - Continued epidemiological research relating to the effects of asbestos on man on Still in progress ) Cohort Study Observation of causes of death in the present cohort of workers of asbestos mines who were born 1891-1920 to be prolonged up to 1972 to see causes of additional about 100 deaths expected until then 2 Mesothelioma Survey All cases from Ontario and Qu^'bec which occur until 1973 to be investigated epidemiologically Additional about 25 cases a year can be expected in these provinces 3 Clinical Study Standard examination of chest radiogram two simple tests of pulmonary function vital capacity and ventilation rate on exercise and a questionnaire of respiratory symptoms to be introduced and their reliability and their relative efficiency to be evaluated 4 Etiology of pleural plaques to be investigated by a case control inquiries b chemical and mineralogical examination of plaque material c geological studies of mines where the JHM 00805 6 ... - ane ::: ::: ' ood Coen on al: faceted ts / 1 erry ROR Iee) oo wom ot or ry) 1.691 Tou emcees McD| onald J.C BeeklaJkIMeIN Gibbs G..W; McDonald 13919 13919 mm McDonald ed 9 ge: PY seer fe wee et eevee + -- wee Ue - > me .; .; Gibbs Gibbs G.W McDonald - McDonald Pir b M.R , Foe J.+ C sme, oe e eMPSe* e sere Bir tet Fo tte pgeraee 2. TET ST ... Rossiter Rossiter C. Dds KEY CODE . KEY WORD THE CHAKAT TEHISTIC TEHISTIC asbestosRossiteRossirter Rossiter C. Beam kane ~ ] - | Thehealthhealth ofchrysotile asbestos J2 mine and mill workers of Quebec . on 33 Arch Environ Health 28 61-68 Feb. Feb. J 14 .* . 0 2 case vee The results of stud.ed of respiratory os + symptoms and function roentgenograph changesand mortality in relation to 2 _. . 36 = dust exposure in the Quebec chrysolile - 7 meses Industry which has employed some oe = *** 28,000 workers are brought together and 43 ae he 69 oom ds soe their Implications for control examined ~ _. Breathlessness on exercise dimin aces Ished inspiratory capacity parenchymal . 60 -- 70 rr and picural chianges and respiratory disease mortality were related to dust expo- ce - sure and to each other Respiratory con- , eens Ene cer was also related to dust exposure wee The overall excess of deaths font to ~ some see = piratory cancers Including five with ma- er - lignant mesothelioma was at most 50 S specific abovo expectation based on ~ talos for Quebec and the mining region . - = If safely standards are set they should be based on epidemiolonical evidence From these data for the chrysolile produc- er mo , . oo rete + ing ingindustry of Quebec a resonable lig ingure based on ^ % risk of acquiring elinieatly significant disease would lie 2 between lo 4 million partieles per cubic . foot calculated for a working life of 50 pn nme ee} ws =~ . x epidemiological years In the absence of findings based on liber counts and lack of ee a satisfactory means of conversion particle counts should continue to be used for control in this Industry Set =s Caron ot oeme te of ' Wrest cere als INDEX TRACING CARD 197 197 - JM 00808 JE 00809 ret Project No. 11 - A chemical and mineralogical study of insulation material Still in progress a The nature of the insulation material used now and in the past in Canada and in the U.S. to be investigated and samples to be examined for mineralogical and chemical composition b ; Samples of insulation material from old boilers and heating systems to be obtained and examined for mineralogical and chemical composition Changes to be sought between a and b Cost 52,000 Dr. Graham W. Gibbs Ph.D. Department of Epidemiology and McGill University Montreal Canada Health JHM 00810 JHM 00811 Project No. 12 - Identification and quantitation of fibrous dust and ferruginous bodies in lungs of autopsied adults Lungs to be obtained from autopsies of persons 1 not occupationally exposed to asbestos whose life has been spent chiefly in urban areas 2 not occupationally exposed to asbestos whose life has been spent chiefly in rural areas 3 . occupationally exposed to asbestos with asbestosis 4 occupationally exposed to asbestos without asbestosis Fibre counts and ferruginous bodies counts to be made in the lungs and compared in order to determine whether there is any relationship between asbestos related disease and fibre content of the lungs This one year study should test feasibility of method available to authors Dr. Paul Gross M.D. & Dr. R.T.P. deTreville M.D. Industrial Health Foundation 5231 Centre Avenue Pittsburgh Pa 15232 U.S.A. Cost 19,921 JHM 00812 : cote ms . nn BULIESENT im 6491 hur saiee Bt Be oe rer - . LEAGEL 10 3749 LOCATION P. R.A. aaapa Davis Davi Davis s Marley mein Cralley Cralley J. , deTreville RTP NOTES KEYCODE CHARACTE WORR D OI R CHS ARACTERT ISTIC CHARI CTERISTC CHARAC CTERISTIC Asbestos identificatioonf fibrous _particles in lungs |J.Occup 23__ J.Occup Med lk_ 757 1519972 _ < in- nonspecificity nonspecificity nonspecificity nonspecificity necesarily necessarily necessarily not are bodiesbodies Because Because Because _ kirruginous Summary kirruginous kirruginous of people tubular excessively people . tubularhave tubular results excessively identitying results people method metho ustel tibers Server excessively tubular rock and into results people and plants way asbestos rock metho it of were into Serveer Serveer results significance glass economical identitying excessively significance Serveer economical way the excessivare denl tify ied aluminum woor Health diffraction unique significance with ashestos units aluminum at nuneral lungs Health diatoms described asbestos servoering ashestos servoering asbestos find exposed Puli the described electron fiballar servoering aluminum leaves of leaves lungs described exposed Puli discussent _ analysis practical inhaleel expensive addition fiballar the which quantitating quantitating series buslogical occupationally % practical electron can readik may the cuntain occupationally are lis quantitattihneg practical inhaleel have have rapid asbestos readik may methods 45 Ir readik lungs identified siinze On sediments occupatocuipationaloy ndiscussaent lly identified microprobe sediments chrysoble microprobe vs 45 country of asbestos as sediments chrysoble TERIT marized chrysoble recognizert respirable Supymutasd dicative definitive developedrepresents about microprobe definitive developed been the asbestos asbestos represents represents hstruuctumre awonol and marized chrysoble represents structure human been Fibrous and and Methods marized marized respirable Methods buelly buelly about the buelly chrysobleis Supymutasd OPE OPE _ _ _ Summary a Vreven serene Guan a4 . 6 6 2. 4t NOCKED * # Ay BATBATEE } NOCKED MY 3 ; 1 eae 1 1 ads HOCHOCUUMENTMEHNTOCUMENT.31 KUMBEN KUMBEN KUMBEN CDITED BY ee ee | j 2 tt PAGE OF 7 . : sd DOCUMENT , 3796 FLOTATION DOCUMENT KIILL GROSS Paul Paul DAVIS DAVIS John M.G. HARLEY Russell A. Jr. & , KEY KEY CODE KEY WORD OR OR CHARACTERISTIC Robert _ T.PscoPE T.PscoPE NOTES 25 27 LymphaticLympLyhmpahattiic c transport of fibrous dust from the lungs J. of Occup Med 15 3 186-189 March . 1973 43 46 The concentrations of inhaled mineral 52 dust and mineral fibers in the lungs and 71 80 a ee satellite lymph nodes uf 30 people wrie ektormined and tabulater fil^er concentrations tanging from nearly four to more than 125 million per gram of dry tissue were found in satellite kympi y nodis Approximately six per cent of all size fibers were identified as chrysolile Alilusugh 94 of the lil^ers temained unulentidest cogent reasons we | ee ee e s. ow: are given for ant believing that a significant quution of thein at man made no culer annesite vir crocidolite wee emene Lime . . cee = oe and for considering two other poslastaler identities No correlation was found ce between fiber concentraticin in lymph nodes and lung nor was there any "+ corelation between the liber con- cx croitation in lymph nodes and cnn centrations of mineral alust in either lng =: cur lym al~-nowles 7 WHE WHE WHE -00813- -_- eaters wn uw Me i see OST ee ' oot : DOCUMENT TILLE TILLE Gross Paul & Harley Russel .: 4 KEY CODE KEY WORD OR CHARACTERISTIC CHARACTERISTIC 01 SCOPE eae ttnt et | 3072 LOCATIONLOCATION LOCATION NOT15 56 The locus of pathogenicity of asbestos 43 Archiv Environ Health 27 240 24O2ct. 1973 44 .45 Tr / 20 80 / Documented experimental evidence as = well as the results of preliminary experi ments are presented which indicate a teduction in pathogenicity as the polyfilamentous arrangement of asbestos dust particles is replaced by a monofilamentous structure On the basis of this evidence it is proposed that the locus of pathogenicity of asbestos dust particles resides in their polyfilamentous structure X REASE PUOW PUOW BOOK REASSE AMZA MAULL PUOW HD TRACING CARD - ae JHM 00815 Project No. 13 - Epidemiological study on the biological effects of asbestos dust at the Balangero Mine - Continuation as a prospective study 1 Causes of future deaths in Balangero miners and miners to be investigated and correlated with same in a control group selected from adjacent villages - 2 The CO transfer in the workers exposed to asbestos to be repeatedly studied and compared to radiological appearance of the chest in order to see whether changes of the transfer factor precede radiological changes 3 Prevalence of pleural calficiations among the adult population of the villages nearest to the Balangero mines to be investigated by survey with 10x10 ray film apparatus 4 Dust concentration measurements to be repeatedly done in the mines in question Dr. Enrico C. Vigliani Clinica del Lavoro Via S. Barnaba 8 20122 Milano Italy M.D. Cost CANCELLED JHM 00816 JHA 00817 Project No. 14 - Fibre shape and biological activity Still in progress 19 samples of fibres glass microquartz and asbestos of various lengths and diameters to be tested for carcinogenicity in groups of 50 hamsters each The tests are designed to disclose whether carcinogenicity of fibrous particles is dependent on some critical shape independent of chemical composition and thus controllable by a general principle Cost 276,000 Dr. William E. Smith M.D. Director - Health Research Institute Fairleigh Dickinson University JHM 00818 yids ds |, ie oe oe vet SS 42 ea ote eS oda ieee SS Re iota (C1 01 i ,i kteteu wr DOCUMENT TERVE = KEY LODE 8 . Smith = == os William William William = .: veece KEY WORD OR CHARACTERISTIC Asbestos tale and nitrites PAGL iad a2) 1 ... ... - ... ... were PAGL of DOCKWEN DOCKWEN 43 3831 LOLA 0 in relation SCOPE NOTES 37 to gastric cancer 50 Indust Hyg .: pp 227-228 May 1973 46 . 12.- . summary . ~ oie . GINOD x RETEN 142 1686E FORM IFN a INDEX TRACING CARO : steteeeeece JHM 00819 - JHM 00820 Project No. 15 - Fibre diameter of dust in mining milling manufacturing and insulation operations ~< A pilot study Still in progress A preliminary study to be carried out of the asbestos fibre diameters of airborne dust to which workers are exposed to a mining and milling b textile manufacturing and c insulation work Five samples to be collected at each of at least 3 locations in each of a b and c All samples to be examined using a scanning electron microscope and the diameter and length of fibres to be measured Results to be interpreted in the light of available epidemio- logical information Dr. G.W. Gibbs Ph.D. Department of Epidemiology McGill University Montreal Canada and Health Cost 18 830 JHM 00821 JHJMHM 00822 Project No. 16 - Study of the health effects relatetdo asbestos exposure in workers of the industry and other residents of New Orleans - 2nd phase In progress 1 Analysis of data collected in previous study IOEH # 8 a correlation of clinical features with radiographic changes and pulmonary function b relationship of pulmonary function and total dust exposure relationship of smoking and radiographic changes and pulmonary function ) A study of mortality in 8,000 previously employed workers in the two asbestos cement factories 3 Follow examinations in yearly intervals of the 300 men aged 40-59 from the original study group IOEH # 8 Dr. Hans Weill M.D.R Dr. Morton Ziskind M.D. Section Tulane Medical School- Section of New Orleans La Cost Pulmonary Diseases 270,000 Jie oggag Project No. 17 - Relationship between asbestos and tissues In progress A. Mechanism of coating in formation of the asbestos body to be studied 1 in the lungs from patients with asbestosis 2 in tissues of animals exposed to asbestos and various other dusts 3 in cell cultures of fibroblasts and macrophages ; 4 in vitro systems incubating asbestos and various other dusts with substances present in asbestos body coating : Studies on the relationship between the asbestos content of the lungs and the degree of fibrosis To be examined 1 lungs from workers exposed to asbestos inhalation with and without fibrotic lesions 2 lungs from comparable exposed populations 3 tissues from experimental animals exposed to asbestos and to various other dusts 4 fibroblasts cultured in vitro with asbestos and various other dusts Cost 45,000 Dr. Benvenuto Pernis M.D. Instituto di Medicina del Lavoro della Universit^ di Genova 16132 Genova Italy . . JHM00825 THM o0 996 Project No. 18 - A factor to convert total airborne dust concentrations using the midget impinger technique to fibre counts as recorded by membrane filter method . In progress At 20 locations at each participating asbestos mine a minimum of 5 duplicate samples of airborne dust will be collected using side by side millipore membrane filters and midget impingers These at be least 1,800 samples will counted at McGill and by participating members of the industry Simultaneously the total and respirable mass concentration of dust will be determined using Hexlet and MRE samplers Objectives are 1 The calculation of a conversion factor to convert midget $ impinger counts to membrane filter fibre counts 2 the description of observer variation in counting fibres using the membrane filter or total dust using the midget impinger techniques 3 Measurement of total and respirable airborne dust - mass concentrations in the mines and mills to examine their relation- ship if any to particle and fibre counts Dr. G.W. Gibbs Ph.D. Department of Epidemiology McGill University Montreal Canada and Health Cost 37,375 JHM 00827 JHM 00828 Project No. 19 - Epidemiological study of mesothelioma in U.S.A. In progress 1 Ascertainment of fatal cases of mesothelioma by getting an answer from every pathologist as to whether or not he has made such diagnosis during the previous year 2 Visits by M.D. to every pathologist who reports a case to review the case and to select a control case ... ... 3 A field survey in which Public Health Nurses obtain occupational and residential histories for cases and controls 4 Pathological review by the U.S. mesothelioma panel Dr. Alison McDonald M.D. Department of Epidemiology McGill University Montreal Canada Cost 59,800 JHM00829 JHM00829