Document mBrD5rzvMLBR0252754jpQ65b

Tm en _ . + E. 1. ou Pont oe NEMOURS & COMPANY CENTRAWLIRLEMSIENAGRTCOHN&,DDEVEELLAOWPAMRENET1D9E8P9A8RTMENT. TOXICOLGEY AND INDUSTRIAL MEDICINE (carbon copies listed on page 3) AR224-1567 May 6, 1981 PERSONAL & CONFIDENTIAL MEMO TO: HP.PD,E. MOSNETRCENHBAENTIZN 642 FROM: CB.. FW.. RKEAIRRNHH,ARDMTD,, MEDR,D", CRNE-D1,140H0ASK(EvLiLc :CAR RamonTomperiTuorooctaFnCc-a1t4e3] Ref. CFReinhardt BWKarrh to HC-E8;SeCrAeSn-b3et8z2,5-26-1) " : WEC-143," dated 4/10/81. - FICo-c1o4mT3mheencdasurseef"detrheaantbcnewoormmmeaenlmo eoydfeescchlrieilnbsdeebssearaiinnpgirlaotctapfaesttcuuisdtyeys.bbye T3hMe inmewmohich rteemnotvieadl frfoorm JJaoocbpkaegsruhoreuernedto ilteFvChe-al1ss43b(ea0en-nd0.4bdelmopoopmnd)s.tlreaAvtreeeldsas othfwahteFrbCe-at1ch4ekt3rgheeroaruieesnmdpplaoobryoaevneegsedheaafnvidened DoTeioenErotSvheievseilaosinraoblfornoaercgcaecnpoitncacbelnfetlruaoertxiipnooensurionfe tFlhiCem-i1t43ofis 0.i0n1 cmogm/pml'ianscheouwlidth present no significant risk to the fetus." arnouinmdOprriecgcoiinnscaeelnlmtyeraaswteuiroeenmsetoniftmaotorefgdantbioltcaolofdloucroorgniancneei,nctrdfaelttuioeorrnimsnien.eofd TFhCe-14b3ackb:y by0-0m.e4asuprp.m a(12%2el1Htlu0oFirniFntCeh-ye1:4b5loSioutdbsseeolffqueWwnaistllmyidnegvateolmnoeptehodof.fdicfeoIptrwroemirseskauesmsrueesrmd,isnitgwthaiasvttehebtaobclkogaorbdoouutnd 0Hl2oe0wv0ee4vlesrp,pbyn ien(4iittphipeabrl),mmeeta3shsoudrfelmwueoolnrueitlvnsdeel.ogfiovfeWItbivllwaomaloisudnegstFoCni-n1o4f3tfheiicsesabmweeolrokwreanrtgshee.indi- orSeatreveeS1tt"hfaetndtehwtehecettbsihahoeconrku,glrdtohtuehbnaetdaclcioesw,petraelbdelssetobthltaohnoedd0.el0te0ve4ecltpipofmno.r lefvTeehmlealeqoufeesmFtpCil-oo1yn4s3 e(0s.00146.4ppmp)p.m) ] EID096478 z g BETTER THINGS FOR BETTER LIVING .. . THROUGH CHEMISTRY. = 000061 . MR . PERSONAL CONFIDENTIAL 1 H. E. SERENBETZ -2- May 6, 1981 We advise against this step because our information is limited. 1. Trhaet eisvidiennccoencltuhsaitveF.C-14T3eraistogaentiecrattoegsetns mienettiheng acnudrrDenut Posnttandaanrddsresaureltsbeisnhgoulcdarrbeiedavaoiutlabblye 3bMy 3-81. 2. Even if the preliminary 3M study is assumed to demonstrate teratogenicity, setting acceptable exposure sittanidsaridnsa.dequTaheteoufro-r reesnttablainsihmmaelntstuodfieasccesphtoaubllde pwroovrikdpelacaebasstiasndafrodrs. The human data now being collected should also help in setting standards. 3. Because of the unusual difference between male " and female rats PC-143, the rat in their rate of excreting may mot be the best model for : man. A better model is being sought. - 4. We need many more measurements before we can say tlhaattiontheofbatchekgrUo.Su.ndwolmeevnel isoflPeCss-14t3hanin 0.t0he04popppmu.- 5. FenCt-14a3dvehrassebeeefnfecitns usien fhuomrandse.cades without appar- not beWe chraencgoemdm e nudntitlh atwe ohuarveacmcoerpetabdleefinbiltoiovde leivnefloromfati0o.n4. ppm We x should have enough information for a decision in a few months. The departments have already taken significant steps to lower exposure to FC-143. A few months, particularly with lowered exposure, should not significantly extend the hazard of a sub- stance that has been in use for many years. J. R..Gibson, Director of Health and Safety, concurs with our conclusions. CFR/BWK/bjd ~ i g EID096479 000062 tot. PERSONAL & CONFIDENTIAL H. E. SERENBETZ -3- " May 6, 1981 cc's to: J. R. Gibson, Admn, D-90S8 W. F. E. E. Tatum, Admn, French, Jr., CD&-P9,064B-17249 . A. L. Dade, F&F, B-2202 A. C. Haven, Intl, D-3047 G. A. Hapka, Legal, B-13373 C. C. Griffith, Photo, RSQ-210 J. T. Smith, PPD, D-12008 J. L. Stowell, PA, D-8112 R. L. Rhodes, Fibr, N-4448 H. E. Simmons, Jr., CRED, D-6036 B. C. McKusick, CRED, Haskell J. G. Aftosmis, CRED, Haskell T EID096480 000063