Document mBe8Mj1YYEedj32gm7DLBq6NB

AR226-2863 Copies to t vE ' I* du Pont de Nemours and Company Haskell laboratory for Toxicology and Industrial Medicine Material Submitted by Organic Chemicals Dept., ACUTE ORAL TEST J S S T B E l* ____________ _____________ __________ lS i? tS e re l ly ln tr` M lr l`! N a t io n to ^ Se level` Survivors were sacrificed 1 kor 15 days later. Dose 22,350 13,700 11,000 7,500 5,000 3,^00 2,250 670 Solution (i) As Received As Received 80 80 80 50 50 50 Summary: Approximate Lethal Mortalitv** D - 1 d. S - lU d. S - 15 d. S - 15 d. S - 15 d. S - i d. S - Il* d. S - Il* d. Clinical Signs Lethal Dose; Lethargy and prostration. Sublethal Doses: Lethargy for 1-2 days and chromodacryorrhea for ALD 22 >350 mg/kg p i r i S S r fS"1?"i5 ?day7s *a52ft?G"rg/d,bogsin61g14aatb5o,v0e0j 0vmetg/akngd/anOdT asbtaoivnee-d riro^dTairmi/L^ dosineat 700^7,500* 5,ooo, *nrnn?if+-?OUth i*0".2"5-days after dosing at 11,COOmg5kg and abore- L . . 0X1 *d WBt body for 1-3 days after dosing at 7,500 mg/kg* dosim ^t 1^ 7on Etain<aTound on the Uth and 5th day after ? o o?TM /vi?' 7 u ^ 'kg; ataxia on the day of dosing at 11,000 and doRlmr^nH6 ' Y?*"88' ldnness, and convulsions on the day after W 1 ?f ?nd BaPiva"tion on the 2nd day after doBing at 11,000 mg/kg. Weight loss from 1-13 days after dosing at 670 mg/kg and above. (AH>) 1b ^ t3 lo X / S n ^ , S t ? ra U y ' ln ln e le aoses' to youD a d u lt " A ' Oim-CD ra te ; it s ompa"X Sanitiied. Does ,,ol co n tai"TM * 061 Composition: **D - ( ) d. = Found dead ( ) days after dosing. S - ( ) d. = Sacrificed ( ) dayB after dosing. JFM:scg Date Issued: October Report Mo. 775-77 1977 1 Report by: Joseph T. Matta Technician ;Approved by: Q .^|^C<lA julQ>. __ ____ A. Michael Kaplan Chief, Oral Toxicology Section CO*?*? LCB1 0QeS ;>.otcontainT5Ci Sander I