Document mBZaX8RM0JRDM8aoVJkx4kaJ0

Verified study diagnoses of approximately: o 500-600 cases of AML o 400-500 cases ofNHL Follow-up of Disease Progression through 12/31/07 Continued maintenance of the JCML Tissue Bank and formal transition of the Tissue Bank to ICMRC. Assessment of Benzene Exposure for above casesand a matched (2x) set of controls with documented IC's and questionnaire administration for all cases and controls. Review and consideration of several data sources for exposure assessment including the IPHS data set, Yang Pu database, the Chinese literature, real-time monitoring in selected factories and simulations to arrive at credible benzene exposure estimates. Development of an EA matrix using the above data sources for all study cases and controls. Continuation of QA procedures for documentation and cooperation with an independent QA auditor. Migration of data RE. diagnosis, confounders and EA to CC study coordinator. Molecular Epidemiology Study Quantitative IH analysis of benzene, toluene, xylenes for workers in 5 factories (est. 500750 workers) in which benzene is present. Continuation of the development and validation of methods for the analysis of benzene metabolites. Application of the above methodology to the analysis of a subset of workers in these 5 factories. Continuation of measurement of hematologic parameters and genetic polymorphisms for workers in these 5 factories Post-Study Professional and Technical Support Final case diagnostic review and completion of CC and DP datasets Post-study data analysis and migration Continued data-analysis (ME, DP) preparation through June, 2008 24 SH ELL-MCCLU RG-059469