Document mBNdwb97qKMpxeRjadjZVzrvQ

Industrial Hygiene Digest Novemoer This effect was evident aiso in a subgroup of the men studied who reported no signs of mild bronchitic sv-- toms (cough and phlegm tor at least three months in a year) . Among men with pneumoconiosis there ws; -- evidence of a reduction of FEVj q in excess of that attributable to their dust exposures, smoking habits, s-e and physique. Increasing severity of bronchitic symptoms was associated with a loss in FEV^ q greater' than that expected from the effects of dust exposure as measured, smoking, age, and physique. Possible ey planations for this phenomenon are discussed. It is suggested that the results may indicate that once earlv bronchitic symptoms are present the disease may progress and ventilatory capacity may deteriorate inde pendently of factors initiating the disease process. --Authors' abst. 1367/73 Aabestos in the Work Place and the Community. M.L, Newhouse. Ann. Occ. Hyg. ljk 97-102, Aug. is?'; 17 refs. The fibrogenic properties of asbestos dust were detected early, later knowledge accumulated about the car cinogenic properties of the mineral and a hazard of bronchial carcinoma and mesothelial tumours was recog nised. Mortality studies have measured the effect of exposure on working populations. Recent analysis of data from a cohort of asbestos factory workers shows that even with low to moderate exposure there is excess mortality from cancer of the lung and pleura and other cancers, after more than 25 years' observation. Tis mesothelioma rate increases both with severity and length of exposure. Occurrence of these and other :u- -- mours appears to be dose-related. The markers of a community effect of asbestos dust in the environment -are the occurrence of mesothelial tumours in neighbourhoods of a source of asbestos dust, and the presence of asbestos bodies or calcified asbestos pleural plaques in the general population. Conditions giving rise to neighbourhood mesothelial tumours may not now occur, but the importance of adequate control in all coun tries where asbestos is mined or manufactured is stressed. --Author's abs:. 1368/73 Hi8tochemical Study of Asbestos Fibre Coating in Experimental Carrageenin Granulomas M. Govema and C. Rosanda Vadaia. Brit. J. Ind. Med. 30: 248-252, July 1973. 12 refs. To study the composition of asbestos body coating, asbestos particles present in experimental i_.-.i' rgeenir granulomas were tested histochemically for mucopolysaccharides, ferric and ferrous iron, haemoglobin, and haematoidin. The stains were applied on microscopical sections both untreated ana treated with iror.- extracting solutions and/or enzymes. The results indicate that asbestos is rapidly coated with haematoid- ferric iron, and hyaluronic acid. --Authors' abst. 1389/73 Effects of Asbestos or Quartz Particles on the Mixed Cultures of Macrophage and 3T6 Cell. K. Kosh. andH. Sakabe. Ind. Health 1: 125-127, Dec. 1972. 1 ref. Study of pathogenesis of pneumoconiosis at cellular level has been hindered by the lack of a suitable r.oc`- system. It may be assumed that the first reaction of cells to inhaled dust particles in alveolar cavity is ^ phagocytosis by alveolar macrophages. The way in which this is followed by fibrosis is obscure. Th* toxic effect of silica on macrophages is documented, and may well lead to the release of factors respons* for stimulation in fibrosis. There is a correlation between the toxicity of various silica particles to m ^ phages in culture and the capacity of these parucles to stimulate fibrosis in vivo, but this relation *B ^ clear in other particulate matter. In this report the authors have tried to observe the effects oi var. on the model system at cellular level. --Cond. *r0IB 1370/73 Improved Techniques of Identification and Determinadon of Airborne Asbestos. L. BartosiewiczAm. Ind. Hyg. Assn. J. T4: 252-259, June 1973. 6 refs. 1371 -73 Collection, identification and data analyzing techniques are presented for airborne mineral fibers. limitations of the techniques are discussed. It is shown that the adaption of a plenum 1 3/4 inches ` ^ 5^ sample collection is important since it leads to a much more uniform particle collection and di=tr aration of the asbestos particles from other solid airborne pollutants with the refractive index 9 f;: is shown to be accurate, convenient and useful in distinguishing asbestos from other fibrous 5 a-5' analysis of this type the image analyzing microscope is a very valuable tool. r - Vs0 J A Radiographic Survey of Monumental Masonry in Aberdeen. T.A.L. Davies, etal. Brit- 30: 227-231, Julv 1573. 12 refs. a- A survey of radiographic appearances of the lungs of monumental masonr.,.rv> workers in Ab_erdeencon:.-- out to determine the present prevalence of abnormalities and to serve as a standard -or iU . -' ir. view of changes m methods of working. No major change could be detected in the tatu^.a*,, m ipr',% workers in Aberdeen ever the past 20 years but the different methods of survey used b- `or-cv t by the present study did not allow of strict comparison. Chest radiographs were reporte ers indeoendentlv using the National Coal Board elaboration of the H.O classification ana a ^.as y TO