Document mBEn466ZDNLpzmR6oKJx9aB64

3M Corporate Toxicology and 3M Center, Building 0220-06-E-0 3 Regulatory Se rvices St . Paul, MN 55144-1000 651 733 1773 Fax p. 1 i - ` Certified Mail January 8, 2007 ~~4e If6'0 NO CBI Document Processing Center EPA East - Room 6428 Attn : Section 8(e) Office of Pollution Prevention and Toxies US EP A 1200 Pennsylvania Avenue N W Washington DC 20460- 00 I RE : TSCA. 8(E) SUBSTANTIAL RISK NOTIC E' 'ON : ,PFHS and PFOS ; Supplemental to Sulfonate-based Fluorochemicals, l:cc ket Nos . 8EHQ-1180-374 ; 8EHQ-0381-0394 ; 8EHQ0598-37 3 Dear Sir/Madam : In July of 2006 3M notified the EPA that prelimina ry data had been received from a study suggesting an effect of perfluorooctanesulfonate (PFOS) and per fl uorohexanesulfonate (PFHS) on body weight, food consumption, and serum cholesterol in 15% dieta rv fat fed E3 Leiden transgenic mice in vivo . The final repo rt for this study is enclosed . If there are questions, or if additional information is needed, please contact me at (651-73713 74) . Sincerely, Deanna J . Luebker, MS, PhD 3M TSCA 8(e) Coordinator Enclosure CONTAfNS NO CBI .~ ; - - -; IIIJJIiI ~ Il 11 U ,- 0 I (1 U U 111 U p 1 ,