Document kmwV59Np63wkLO1DgjqQdykjy

FILE NAME: Chemical Abstracts (CHAB) DATE: 1953 DOC#: CHAB036 OCUMENT DESCRIPTION: Abstract Originally Published in 1952 by Fairhill H\ 1953 2361 . 11H--Pharmacology 2362 the VI as much at a.dose of 25 mg./kg. as II did at 50 m g./ concn. of nicotine from 0.01 to 0.2 M for 60 days and when kg. HI, IV, and V were inactive at doses of 500 mg./kg. given for 100 days in 0.005 and 0.01 M nicotine soln. were In mice the oral LD> doses, in g./kg., were, 1.5-2 for I, in brain cortex: - 1 0 , - 2 2 ; - 8 , - 1 8 ; - 7 , -1 2 ; in kid 12 for II, 5-6 for III, and > 10 for IV and V. I was 20 times ney: --20, --35; --15, --26; --7, --22; and in liver: more toxic intraperitoneally than orally. C. D. J. , + 5 , +33; 0, +13; _+10, +35. S. Kitaoka Estimation and comparison of histamine release by muscle Significance of spinal cord for the action of caffeine, relax&nts in man. W. Sniper (Victoria Infirmary, Glasgow, cocaine, etc., on blood pressure. Bunzaburo Nuki, Wataru Scot.). Bril. J. Anesthesia 24, 232-7(1952).--d-Tubocur- Kaida, and Hideo Nozuhara (Kyushu Univ., Fukuoka). arine (I), dimethyltubocurarine (II), gallamine triethiodide Folia Pharmacol. Japon. 47, No. 2, 66-7(1951).--Caffeine, (HI), and decamcthonium iodide (IV), at concns. said to be" "cocaine, and morphine raised blood pressure of decapitated equiv. in muscle relaxing potency, were injected intra rabbits. They lost the action when the spinal cord was , dermally into human subjects. The area of the wheal, pre destroyed, while pituitrin, BaClj, and digitalis retained sumed to arise from histamine release, was compared in their actions. Cocaine injected intraspinally (cervical) in each case with that caused by a control injection of HjO. i normal rabbits notably lowered blood pressure and later I and II were equally potent in causingshistamine release. raised it._ Percaraine did not show this delayed effect. Ill was 75% and IV about 50% as potent as I. C. D. J. Caffeine increased pulsation of decapitated rabbits; after The black-rotten sweet potato, n . Toxic action of the destruction of the spinal cord the effect was reduced and in essential oil of the black-rotten sweet potato. Hiroyasu some cases, the pulsation decreased. S. Kitaoka Watanabe and Hisayoshi Iwata (Kyushu Univ., Fukuoka). - - Pharmacological study of Digitaria ischaemum. H. J . Agr. Chem. Soc. Japan 26, 180-3(1952); cf. C.A. 46, The influence on the blood picture. Yoshie Kajimoto and 9203A.--Rats (00-70 g. body wt.) were not affected noticeably Kaichiro Harada (Tokushima Univ. Med. Coll.). Folia in growth when they received orally 0.01-0.02 g. of the Pharmacol. Japon. 47, No. 2, 81(1951).--D. ischaemum essential oil (I), prepd. from the black-rotten sweet potato has been reported to have desirable therapeutic effects on as formerly reported, per day for 20 days. They were af- ' patients subjected to irradiations (x-ray, y-ray, neutron, fected remarkably with 0.02-0.03 g. I. Oral administration etc.) of the at. bomb at Hiroshima in 1945. It was extd. of 0.1-0.2 g. I to rats (120-150 g.) and abdominal injection with water at 80 for 2 hrs. and treated with Pb(OAc)j of 0.0075-0.010 g. I into mice (20 g.) were fatal within 27-42 to give MeOH-sol. prisms (I). Rabbits irradiated with x-ray hrs. and 24-48 hrs., resp. On autopsy both victims showed - . (voltage 153 kv., secondary current 3 ma., distance 26 cm.) fatty degeneration of liver, hemorrhage of lung, retrogres for 20 min. were observed for changes in blood picture and sive change of heart, and injury of small intestine, kid after 3 weeks were injected intravenously with 0.174 g./kg. neys, and stomach. Fowls lost their appetite when 0.2 g. I body wt. of I. I increased the leucocyte no. to max., 2 per kg. body wt. was given, and some parasites in them were times as much as before the irradiation, at the 5th day and expelled. Dosage of 0.3 g. I/day was harmless to adult c then decreased it to the original no. in 1 week. The per humans. In the urine of adult rabbits orally administered centage of lymphocytes decreased by the irradiation was 0.1 g. I/day for 10 days, there was observed 1.3-fold in further decreased by the I injection, while that of the pseudo crease of creatinine, and 1.5-3.0-fold increase of acetone eosinophile leucocytes was increased abruptly. The blood bodies; creatine increased remarkably for the first 2-3 days pigment and the erythrocyte no. were affected slightly by I. followed by gradual decrease; glucuronic acid slightly in-~ S. Kitoaka creased; urea did not change in amt., and neither protein The colored compound excreted in santonin-urine. nor indican was found. III. Chemical properties of ipo- Yoshito Kobayashi and Takeo Bando (Univ. Tokyo). meamarone. Hiroyasu Watanabe and Sadao Nishiyama. Folia-Pharmacol. Japon. 48, No. 3, 213-14(1952).--Human Ibid. 200-2.--The semicarbazone of the main fraction, t urine obtained within 5 hrs. after giving 0.1 g. santonin was b 127-8, of the crude I was decoinpd. with 5% oxalic acid colored red by adding 5% KOH and it was fractionated. to give pure ipomeamaronc (II), CuHnOa, dl 1.0260, 1 No relation between the effect on Ascaris and the coloring I. 4831 [a] if, 21.6. II was reduced catalytically in AcOH intensity was found. S. Kitoaka soln. to form hexahydro-II(III), and in EtOH soln. to form The influence of irgapyrin on water retention and carbo tetrahydro-II (IV); III gave the reactions of ale., while IV - hydrate metabolism (irgapyrin-edema and irgapyrin-gluco- gave no reactions of ale. but those of ketone. These indi suria). H. K. v. Rechenberg (Kantonsspitals, St. Gallen, cated the presence of 2 C:C groups and 1 CO group in II. Switz.). Klin. Wochschr. 29, 726-30(1951).--The litera II, III, and IV gave the reaction of a methylenedioxy group, ture on the pharmacodynamic action of pyrazole compds. is OCHjO, and the detn. of phloroglucide produced by warm- i reviewed. Of the side effects of pyrazole derivs., the anti ing II at 80 with 1% phloroglucine in 19% HC1 soln. indi diuretic and the glucosuric effects under irgapyrin (Geigy) cated the presence of one OCH:0. II did not react with (IP) medication were given special consideration. In 20 carbazole (cf. Votocek and Vesclv, C..4. 1, 1287), thus ex patients out of 450 treated with IP extensive edema was cluding the possibility of having OCH;0 attached to singly observed, and in 5 cases glucosufia without hyperglucemia. bound C atoms. If OCHiO were attached to a benzene- Examn. of 12 persons showed a clear diuretic retardation ring, it would form acridine (cf. Freudenberg, C.A. 33, under IP similar to that produced by its two components, 31439), but the expt. gave a neg. result. From these data, 4-dimethylamino-l,5-dimethyl-2-phenyl-3-pyrazolone and II must have 2 rings other than benzene, one of which con 4-butyl-l,2-diphenyl-3,5-pyrazolidinedione sodium. The tains OCII2O. S. Kawamura and I. Uritani sp. gr. of the urine increased appreciably following intra The hypnotic action of antihistaminics. Kivoslii Tanaka 6 venous injection of IP, whereas, in the controls it decreased (Tottori Univ.). Folia Pharmacol. Japon. 47, No. 2, 30-2 slightly. This effect is similar to that of hypopituitarism. (1951).--Benadryl hardly shows hypnotic action in rabbits, Glucose dosages and the detn. of blood-sugar values during mice, and children; this suggests a close relation with brain .3 hrs. immediately following the i'P injection gave no essen development. In rabbits a hypnotic action appears when-- tial difference in the curve followed from .hat of the un applied directly to the sleeping center or its vicinity in the treated control. It is suggested that the action of pyrazole brain. By ordinary injections the other parts of the brain compds. is through the midbrain and thus parallels the appear to be excited simultaneously so that other excita mode of action of adrenocorticotropic hormone and corti tions suppress that of the sleeping center. Injections after sone. 42 references. Eleanor Grunwald Kuhn administration of urethan produce further hypnosis in rah- A Toxicology. Lawrence T. Fairhall (Yale Univ.). Ann. bits. S. Kitoaka Rim. Med. 3, 265-82(1952).--A review with particular The influence of cocaine and nicotine on the tissue respira reference to the toxicology of arsine, Be, Cd, F, Ga, Pb, tion of cocainized and nicotinized animals. Iwao Yamamoto Hg, agene, rare earths, Si, asbestos, CeHe, halogenated and Yutaka Kurogoehi (Nara Med. Coll.). Folia Pharma- _ methanes, amino and nitro C derivs., silicones, CSi, and cnl. Japon. 47, No. 2, Proc. 50-1(1951).--As detd. by the insecticides. 139 references. Theresa McKee Warburg manometer the changes (%) of tissue respiration Curariform substances from roots of Cissampelos pareira. in brain cortex between normal and cocainized rabbit with S. N. Pradhan, C. Roy, and K. S. Varadan (Central Drug daily 2 cc./kg. injection of 0.1% cocainc-HCl for 60 days, Research Inst., Lucknow). Current Sci. (India) 21, 172 and for 120 days when given in 0.005 and 0.01 M cocaine i (1052).--The alkaloidal ingredients of curare are increas soln. were: --28, --41; --33, --40; --45, --57, in kidnev: ingly important in medicine as muscle relaxants because - 1 5 , - 3 1 ; - 1 4 . - 3 6 ; -2 5 . -5.3. and in liver: +14. of their neuromuscular blocking effect The curariform