Document kmp20zLRmy6qz8vDr1Zywa9pb

Younger Laboratories ... PkatmaadoqUU ... Antiaabbf&fiU 111 CLIFT C1VI ROAD Saint Louis, mo, lain PRONE! TILDIN 6-9S40 SUBJECT Toxlcologloal Innatifatlon Oft FTSMOL 2 8 0 Novaakar 9th, 1946 wnhtil aara arataa* aaoTooaopIaolly. Dm 4ata in ahaoa la Ml* 1. ) aia mwrttia ms (hahhita, dm sm) Iha miMi iM|Wil m April*8 la laaraaalac Imn at laaraaaata af 0.2 fraotiaaal l*f latanola to tha olaaaljr ollppat, lataat akla f Mo 7--1--^ ahlta aala aat faaala rabhita. '- - Tha traatat apoaa aara aaaara4 alth plastlo atrlpa api tha aalaala plaaat la Nta atoaka far parlata ap t* toaatp-faar haara, ittar Odak tiaa Mr aara aaalpaal to laAlrltaal aagaa. Otaarvatlaaa aaoa aa4a /hr taada apaptaaa aa4 tha tlaaara af tha -1--' ttet auaaoMa* aapo aaaalaai aaaraaaaploallj. Iha 4ata ara ahoaa la hMa IX. ' MONS 037886 TU. maMmMiI vapart i. a.1 N> b. an4 la Bay fm A *4nrtfetn withoal wHlwa yRailihiia Toi Won--ato Coop*ay St. I--ila( Missouri lauapar Laboratories Cortlfloat* *f Analysis - Pag* 2 (11/9/6*) * T-6S-161 smuor - PIPBAgl 2 8 0 A) Oral LOyo (Rata, Mixad Saw) lb* Oral Up* far aala aad f--ala rat* aaa plaoad at 8,440 nilllgraa* par kllopraa altk laaar end upper llalta af 6035 to 10,380 all11proa* par kllagr--. Th* ooapeuad aaa alaaaad aa prectloally aaa-t--lo bp oral iageatloa la aal* aad faoala rata. B) (kia Ak--rptlaa KU> (BakUta, Mixad sax) Aa Miala-- Lethal Das* by Hdi Ab--iptloa la aal* aad faaal* rabbita aaa faaad t* b* greater thaa 2000 adlUpra-- par kllapraa aad laaa tins }1<0 ailllpra-- par kllapi--. lb* oaapaaad aaa alaaaad aa allphtly taal* by --la ab--rptlaa la aal* a-- faaal* rabbit*. TOOna LABOBATOBXM The material ia this report 1* to ba uiad In development ol tha product aad nay ba given to reepoaelbl* eale* contacts, but it ia not to ba uaad by them ia advertising copy. Tba source of this material ia not to be divulged until it appeal* ia formal publication*. No exceptiont to thteatabliabad rule may be mad* without the approval of the Medical Depart, meat in St. Louis.Hustomers' inquiries regarding --Mm *f toxicity are to be referred ae before ta th* Median! Depart maat in St Louie for reply. HONS 037887 toi Nooaaato Coapaap St. Louts, Missouri IouB(r Laboratsrlaa Cortinosts of Aaslpala - Psps J (11/9/U) . r-64-l6l TAILS I TIC QBAL LO]g OF 'PTD8AUL 210' 201 IASS SsspXo fad Ba*ilata* Anjaal No. - Saa *al(ht aa. 1- fseals 2* Halo 5- raaalo 4- Mala 9- raaalo 6- Mala 7- raaalo a- Mala 9- roasis 10- Mala U- raasla 12- Mala 19* raaalo IV Mala 19- raaalo 16- Mala 17- rsaala IS- Mala 19- raaalo 20- Mala 220 299 2)0 240 219 260 ' 229 290 220 270 229 269 2)0 290 229 2<0 219 299 210 240 Doaa StUHi t, no 6,910 ,)10 6,910 6,910 7,540 7.940 7,940 7.940 7,940 10,000 10,000 10,000 10,000 10,000 12,600 12,400 12,600 12,600 12,600 ______ fils__ Sorrlrad Buraias* Survive* Surrlaad Dlad Survive* Ola* Buraiaad Died Survive* Suralaad Ola* Ola* Burrlaa* Suralaa* Ola* Ola* Ola* Ola* Ola* DISCUSSION - Iks Oral LOm for ssls aad foasis tots ass plaaa* at 1,440 .m slth lossr aad upper llalts of *,)) to 10,9*0 aUllpraas par kllaciaa. Tho aoapouad too slaasaS as piastlaallp raa tnrl o bp oral iacaatlaa la asls aaS faaala rats. Surrirsl tlso saa ssseral hsura to fear daps. ISala apaptoas lasladad traasra after tas to tkraa hoars, lathaatp, loss sf appotlta, sad collspas. At aatspap thara aas Inflaaaatloa of tho (astrio aaoaaa as soil as liaur hppsraais. MQNS 037888 Toi Moaaaato Coapaar St. ImU, Missouri louseor Hhoratorioo Csrtlfioats of Anal/sls - Pags 4 (11/9/66) - J-66-161 imi 11 THX MINIMUM LETHAL DOSE 07 'F1DBAUL 2 S O' n sun assonpixon in babbits Saaplo Appliol UnHUtsl Ailaal *pj_- its toifht H-- Doao Hi./Ka. Wsi*ht Chan** 9 Days Latsr . . Ka. 1 - Milt 2.6 794 2 - rsaals 2.3 1260 3 - Mala 2.7 2000 4 - rsaals 2.3 3i<o i - Malt 2.7 3010 6 - rsaals 2.3 7940 0.0 - 0.2 - 0.2 - 0.4 - 0.3 - 0.3 ftt* Sarrltsl Sartlstl Sarrlrti Dlol - 10 Daps mol -- 7 oapa Bisl -- 7 Dora DISCUSSION - Iks Minins Lathal Doss hp Skla Ahasrptioa la aals sal fasals rahhlts sas fowl to ho srsatsr than 2000 rtlllirisi par kilagiaa aol lsaa that 3140 atniima par kilogm. Ths asapsual sas olasssS as slicktlp toalo hp skla abssrptlsa la aals sal ftaalo rahhlts. SurslTal Um aaa sssas to tsa daps. taels apaptsn laslalsl ssskssss sal lnastlrltp aftor too to thrs* asps foUsasl hr troaora sal oollapao. At aatopap thoro sas llssr iskplratloa sal Ussolsratlsa as soil as palaoaary osassstlsa. 037889 HONS