Document kmo6b19VYg5eYKKZxV7KRVg8O

2004 Meetings and Conference Call Schedule: June 23 (2:00 p.m. EDT), July 21 (Meeting), September 8 (11:00 a.m. EDT), October 19 (Meeting), December 15 (11:00 a.m. EST) 2 SH ELL-MCCLU RG-06S469 4/25/04 Shanghai Health Study Subscription Research Background Information Subscription Research Programs are research projects that are funded outside of the regular API dues budget structure to fund research on behalf of the petroleum industry. These programs are designed to enable funding by both API members and non-members. Subscription research programs serve as a vehicle to conduct large, long-term research, which can be difficult to accomplish within the current API yearly budget cycle. The Shanghai Health Study is the most recent addition to the subscription research programs administered by API. Shanghai Health Study Purpose: To gain an accurate understanding of the relationship between benzene exposure and the risk of certain hematopoietic (blood and blood forming organs) diseases. This study is an important element in the product stewardship programs of participating companies. It can also lead to improved benzene-driven, health-based regulatory (e.g., ambient air, water & occupational) standards worldwide, by providing the regulatory and scientific communities with information for more accurate assessment of the risks from exposure to benzene. Benefits: Information gained from this project will have a direct relevance for worldwide regulatory standards designed to protect workers and the general population from benzeneinduced disease. These include air and water quality standards, as well as hazardous waste and site remediation standards. These studies will assist 9#t~~P#t~#g9mp~i~$ (or, industry) in achieving the highest product stewardship goals and in oversight of their risk management programs. A unique set of circumstances exists at this point in time in Shanghai to conduct meaningful benzene research. These include a database of occupational exposures in a different regulatory environment, and willing and qualified co-investigators influential in local scientific medical, and regulatory establishments. Therefore, questions that have plagued (plagued seems a little strong; how about questions that have been troublesome for) benzene health risk assessment for decades appear to be answerable in Shanghai. The Studies: The program involves three inter-related studies: Case-Control Study - A hospital-based case control study to investigate the potential relationship between benzene exposure and both Non-Hodgkins Lymphoma (NHL) and Acute Myelogenous Leukemia (AML), including an attempt to quantify the potency of benzene for the AML response. Disease Progression Study - A hospital/clinic-based investigation of the relationship between non-cancer diseases of the bone marrow (e.g. xxx, yyy) and AML (cancer) to determine if effects on bone marrow progress through non-cancer stages to an ultimate leukemia. This study would also attempt to define the shape of the dose response for possible "precursor" diseases and could result in characterization of unique identifiers of benzene-induced AML. Molecular Epidemiology Study - Investigate if there is a quantitative relationship between benzene exposure and potential early indicators of both exposure and effect in a focused population of workers. (This is not my understanding of the ME study. I thought that it was SH ELL-MCCLU RG-06S470 4/25/04 looking for bio-markers as indicators of change resulting from benzene exposure. Also, this implies more on the exposure side than I thought that we could expect.) The investigators are leading experts in their fields, coming from such well-known institutions as the University of Colorado Health Sciences Center and Fudan University Medical Center and Applied Health Sciences in the private sector. The combined studies apply cutting-edge, 21 st centurytechnol()gies. ill. ",ays. t~at",illl1otonly. <l~vallce .ollrunderstall~illg .ofbellzelle~induced disease, 9ijtm4t.Y:U$Q it:t1"l.t~fYPQtijt~:UPl"YijtiQ1"l. $tl"4t.tgi$9~1"l.8m(:1ijt:t (:1i$~$ iij m<tjy~<t:q~l$, (how is our study doing this?) Challenges: The proposed studies meet several technical, ethical, and cultural/political challenges. Technical - In order to stand up to scientific scrutiny, studies must be large, well-managed, independent, and incorporate the latest technology. State-of-the-art research is absolutely necessary to make real progress in developing sound benzene risk assessments. To that end, a Scientific Review Panel made up of leading experts from a number of fields relevant to these studies has reviewed and endorsed the research protocols. Additionally, the protocols have been reviewed by Use of Human Subjects Committees (lRB) both in the US and China. Ethical - To address the ethical issues, the study protocols have all undergone a thorough analysis to ensure that they meet international standards for research involving humans, including that the subjects and participating communities benefit from having participated in the study; that confidentiality is preserved, and that researchers are working with local regulatory authorities to improve worker safety. An Ethics Review Panel is part of the oversight for the project and includes a Chinese bioethicist. Cultural/Political- A key to this program's success is local partnerships. Collaborators on these studies include researchers from the Medical School at Fudan University, the Institute for Public Health Supervision, and the Shanghai Municipal Centers for Disease Control and Prevention (the latter two are responsible for occupational exposure monitoring and enforcement in Shanghai). Sponsors, Benzene Health Research Consortium BP, ChevronTexaco, ConocoPhillips, ExxonMobil, Shell Chemical Company SHELL-MCCLURG-06S471 DRAFT AGENDA DOWNSTREAM COMMITTEE American Petroleum Institute Wednesday, May 12,2004 - 8:00 a.m. - Noon CT- Houston, TX 8:00 a.m. 8:05 a.m. 8:30 a.m. 9:00 a.m. 9:30 a.m. 10:00 a.m. Continental Breakfast 7:30 a.m. Introductory Remarks Presentation by a Member Company on Activities to Improve Environmental and Safety Performance National Energy Bill Status and strategies for the future Action: Provide guidance on further advocacy efforts NAAQS Review EPA's anticipated final rule implementing the 8-hour ozone standard Results of April 23 NAAQS strategy discussions among API committees ofjurisdiction Action: Provide guidance on advocacy goals and objectives Fuels Committee Activities Review EPA's non-road diesel rule Northeast states initiatives: low sulfur heating oil, regional fuels NAAQS implementation issues for fuels Auto's Top Tier Gasoline Program Action: Provide guidance on strategies to address the above API Health Effects Subscription Research Programs Overview of API Programs Status of Shanghai Health Study (China Benzene) 0 Potential business impacts 0 Use in advocacy Gary Heminger Chair, Downstream Committee Jeet Bindra, ChevronTexaco Patricia Richards Chair, Transportation Fuels Committee Bob Hermanson Chair, Title I Task Force Gerry McPhee Chair, Environmental Strategies Committee Mike Leister Chair, Fuels Committee Ed Murphy Downstream Group Director Patsy Clegg, Chair, Benzene Health Research Consortium Oversight Committee 10:45 a.m. 11:15 a.m. 11:20 a.m. 11:30 a.m. API Involvement in International Activities World Petroleum Congress IPIECA (global climate, corporate reporting, transparency, corporate social responsibility) UN Partnership on Clean Fuels and Vehicles Update on Strategic Communications Steering Committee Next phase of planning: envisioned future DOE's FreedomCar & Fuel Partnership Executive Steering Group Activities Partnership operating issues: intellectual property and confidentiality On-board fuel processor R&D continuation: DOE's decision- making process Marketing Committee Activities Update Gasoline supply and communications activities, underground Brian HarneylBrian Doll ExxonMobil Pamela Beall MarathonAshland Joe Kaufman Chair, Fuel Operations Group Mary Ellen Peters Chair, Marketing SH ELL-MCCLU RG-06S472 11:45 a.m. Noon storage tank legislation, SPCC litigation, effluent guidelines rulemaking Other Business Review 2005 Budget Time Line and 2005 Major Issues Adjournment Committee Ed Murphy Gary Hemin~er 2004 Meetings and Conference Call Schedule: June 23 (2:00 p.m. EDT), July 21 (Meeting), September 8 (11:00 a.m. EDT), October 19 (Meeting), December 15 (11:00 a.m. EST) 2 SH ELL-MCCLU RG-06S473