Document kmE7g6nwXGB3w76eL5KeDavKn

AR226-2896 E. I. du Pone de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 HASKELL LABORATORY REPORT NO. 239-81 MR MO Haskell No. 14,008---- Study Initiated/Completed ----4/7/81-4/9/81------ Material Submitted by 'Polymer Products Department Experimental Station SKIN IRRITATION TEST OH RABBITS Procedure? Six aale New Zealand White rabbits were the trunk and lateral area asd placed in PDA-type clipped free of hair on test 1/2" material 12-ply were applied ae aqueous paste to stocks* intact skin Doses of 0.5 gm and 1 1/2" x 1 of was then gauze squares were secured over treated areas. loosely wrapped around the trunk and secured with Rubber sheeting adhesive After 24 hours, the rabbi were removed froa the stocks, the tape* patches taken off and the reactions observed. Observations were also made at 48 hours* 24--Hour Observation Erythema Edema 48-Hour Observation Erytheoa Edema 1/6 Slight 5/6 Negative 6/6 Negative 6/6 Negative 6/6 Negative SunmaryTj^BBB^BBBBBBBBBBBfclyaused 4sh8a-vherd. oinbtsaecrtvartaiobnb*it skin after a 24-hr. applicsalitgiohnt aanndd nnoo iirrrriitcaattiioonn aont the good Tinhdisusmtraitaelrihayl gmieanye cause slight skin irritation. If skin contact occurs, soap and water. practice would be to wash any contaminated area with Company Sanitized- Does ""* c""??'" TRC& r^ Report by: Reviewed by: of^^y^--^l J^!y^.^^^^L>e^4 I^nn S. Silber Technician ^b^ O/ ^ w i 0. Lout's Dashlell Study Director Approved by: JESis^jJi-f. Gerald L. Kenngfly Chief, Acute Investigations Section LSS.-jtd ----------'3 Date Issued; April 23, 181 - 2 - Sai^pany Sanitized. Does na'i conSaIn TSCA CB1