Document km1n69a1Og24vezpppnaZ9g1V

'V n* v:f. r i*< *i y...... . or \crivi n i `: \! <nr.vcrs (it. \r.fsurfCf i:v.o A*. :l;A l U T U F \ M i l V I M S fA llON r<;i u,! v r.m or i m ovoi o.iv A i*::--.o s.\s . lANfi >t.o r.\*t;:\11>,r\r;y kjr.MrJF.cmiiprma :n: December3, 1968 * *> Dr. Cummings Paton Organic Division Development Monsanto Company 800 llorth Lindbergh Boulevard St. Louis, Missouri 63166 BeEfr;. Dr. .Paton: .* ** I wonder if it would be possible to obtain from you 100-gran research samples each of the following Monsanto P.roclor plasticizers of your highest available com.v.ercial grade of pur itvs Monsanto numbers 1221, 1232, 1242, 1248, 1254, 1260, 1262, 1263, 2565, 446b, and.: 5460. yhan): ypu_ in _advance.for,your,,gpur tesy. Sincerely yours, V * ( In**' " ') .*7 / ^/t // * i H, Francis A. `Gunther Professor of Entomology FG :b); tr / ' C ' L C C - v- ^ "ti L A * * NEV 031160 780698 ,, t , I.,,V >k< tfccc.r.bsr 9, 1?S8 AViKhOR ? M jO. K, V.'heeler - KV7H V*l WUM><V. r E. 'flicker .JKQ R. K d 3or - J?*o \l. Johnson woc:m K. Welle KVr7:i,L F. Bcnir.nuc/J, Bryant R. Munch JFQ The iesues on Aroclor tonicity testing are cc.r.olicated X know you el an to Issue written nro^rnm objectives, My understand irvg after last meetins 12/6/66 is as fellows: 1. Determine whether Jensen and Co, really have Aroclor or not in tissue of birds: (a) by putting Aroclor through rats and . chickens and seeing if \ie get the same or different peaks than found in Jensen paper, (Use mass spectrograph for check,)* ) by getting hold of tissues frerr. nature which others siy is Aroclor but which com r* be pn*f nthsr covtnounds. Use r.sr-s spectrograph to check vs, nown Az'oclor results. 2, Determine a tolerance level for Aroclor in feeding studies. Run a material balance on Aroclor to find out where it ends up, 3. Determine 'whether Aroclor is an enzyme inducer which affects steroids and Ca metabolism, (I really don* U know wha*c I an* saying here but you can clarify,) ,i. Keep track of what Govt, research labs are coins in way of testing, plus interpret their results for Monsanto, :5 Keep track of what in the way of geog: FC3 peaks, end in 1 doas this mean in * Monsanto. Check w oratorio,". Contest Raeyer In Gcrmvny to see if* they hove taken ry action, Keep track of Japan incident through MMK; * 031Ui l-;. It. Richard 6A December* $*. ' k J** it LVi .i j* _ K'./RLT, } . V. *;r,.i or - l i K v i Arou i o'rl. * 1 c C u Discussion v.'.'.tPi*. h. V. u o';r :;on - KVi'/M C. fa t or: - CPATO ?. B. Hoi gC 51 - i n odo V/. n. R ic h s rd K. a!* "i'el i l . D. - Ki WHICH .1 b e l i e v e the :'o] low! r-.g summaric s? b r i e f l y our d i s c u s s i o n s . F r i o ay : 3) Dr. Calandri'; i s to uose s e v e r a l ehioktr.* v.lth the /-.rodo to make a v a i l a b l e ample t i s s u e s f o r or.c.]ysir. by i>ccc-; T.icke Thu ol.cs to he used w i l l approach the lethal* dose l e v e l s . A p p r o p ria te t i s s u e s arid, orarne w i l l be f r o z e n and forwarded t o St*. Louis f o r a n a l y s i s . This i s in tended t o y i e l d some pros? - in d ic a t io n of r e t e n t i o n s i t e s and l e v e l s in f o w l . * 2 . Dr. C*: l a n d r a ' i s to b e g in 30-day "range f i n d i n g " to x i c i t y s t u d i e s w it h rati< on each o f the f o u r A r o c l o r s which have been s e n t to him. The purpose i s to e s t a b l i s h l e v e l s which w i l l be a p p r o p r i a t e f o r chronic, t w o - y e a r s t u d i e s . A d d itio n s a 0?.]y I- i s c f - e x c r v t u s.r.d a p p r o p r i a t e organs and t i s s u e s w i l l p ro vid e sono i n f o r m a t i o n no to m e t a b o l i c pa thw ays, r e te n tio n r.r.c /'*r acc.v.rulotion hpi^nn^n (j** 1n:l c a s e d nv cheaiical analysis using "coU'." m aterial). 3) I t i s a n t i c i p a t e d t h a t the long rangf. (tw o -year s t u d i e s ) could be i n i t i a t e d sen;: a f t e r completion of thn 30-day studi w i t h i n the next CO to pO days. T h is i s n o t a commi hment, however, to begin the two-year studies at that time. . Jj) The a c t u a l preparatici*; o f "hot" m a t e r i a l i s t c be h e ld i abeyance but e x p l o r a t i o n as to the a v a i l a b i l i t y and c o s t of tagged m a te ria l i s to bo continued and firm ed up. !) The a v v i s a t i l i ty o f d e t e r g i n g the c h a r a c t e r and p c s s i b i l o f i s o l a t i n g the"r.ajor f r a c t i o n 1.* in each o f the A r o e l o r s to be s t u d i e d i s to be e x p l o r e d . 0) I t would be h e lp f u l f o r Lcott Tucker to obtain appropri- cini.v.ai orguRf. end t i s s u e s t*> become f a m i l i a r w ith the e x t ra s i-.nd aii.Mytic.M t e c h n i q u e s u sin g a c t u a l spe cim ens. (T. have a "I>. aay arrangedd iwk'..itnh ? roc d YYooungger o f Younger Labora t o r i e s i P;>l-*yV'* Lt ' ?3;> ci;re rii; from r a t s c(j a!... co .pc l.u .1? V.'e w i l l J iv. -c irk.ee V vd to p ro v id e us k? Js re i t l y d o sin g v;it .. j .'j Tl.c so eh culli b 1,. j - Vi;* , Lt w i l l p ro vid e S c o t t an o p p o rtu n ity to f u r the 0 . 0. pr. re p o rte d Lr. the- H i e ra l u r e . NV 0311&2 780700 W. K. Kl cm; rei P- December 9# 19'38 7 ) Analytical work should be initiated to determine the decomposition products when represent?.tive materials (paper) containing Arcelor are burned. B) There should be follow-up with the fish and wildlife people at Pa tu;:cat with a request for duplicate samples of some of the tissues in which they have identified PCBs so that Scott can attempt to confirm their*results. 9) There should be further discussions initiated -with Kisebrougl* and others around the country whom we have not yet contacted but who we believe to be actively engaged in research projects looking for the PCBs. 10) It was deemed advisable to arrange more formally for the correlation and analysis of all of the publications end bits of information whicn are available.- This would include possibly statistical analysis by someone with appropriate biological and biochemical background as well as statistical analysis capability. )1 ) It was the consensus that the group should schedule inoni*.>*1y yn ntingC tO rCViC ; pregrutoa. The first such meeting was tentatively scheduled for January 15 at Dr. Calar.dra's Laboratories in Chicago. heeler cs NfcV 3U*>3 780701 v. H. Richard - Research_Conter Ds cember IS!> 3-SiSft V!n.DLT.r." .. AROOIOW J2. Scott Tucker Res, 2 $. Second Street ec K, Viheeler Vi. K, Johnson K. Well R,. Davis P. Bculgnuu/J. Bryant W. Kuhn Eki-EE V'JOHH kv;etj. RDAVI PBS21 VKUHi I have asked Jim Sullivan to order 5 gal. each of the chlorinated naphthalene scries containing from 1 to 6 chlorine atoms. Seme of the chlorinated naphthalenes could bo fed to chickens.and the tissue extracted to see if these compounds elute in the GLC at the same positions as Ai'oclor, I understand you plan to run DDT, Aroclor, Toxaphene and Cl naphthalene. Are there any other likely candidates of a similar chemical nature? /it*fav*,/ W. R. .'Richard *ms \ O NEV 031164 780702 1 780705