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/ THE HOSPITAL FOR SICK CHILDREN GREAT ORMOND STREET. LONDON, W.C.1 Ch a ir ma n > CLAUDE A. LUCAS, e s q .. T.D.. m.a .. f .c .a . Ho u s e g o v e r n o r a Se c r e t a r y : G. J. PtLLER. F.H.A. Dear Jr. Aehoe, TELEPHONE: MOLBORN 9200 2jth Te l e g r a p h ic Ad d r e s s : GREAT. HOLB, LONDON August, 1964 On nj return from holiday Sir Alan Moncrieff has passed your interesting letter to me. It may be that we have not .made our point clear, hy the ``normal range of lead in blood11 we mean the levels we found in a series of children exposed to the environmental lead of a city like London but who have not been chewing at all sorts of objects. I would fully appreciate your conclusions about the levels of lead at 'which clinical evidence ox toxicity definitely is apparent, ro my mind, much work remains to be done to determine whether there is any evidence of damage as a result of the intake of lead so that the level in the blood lies between that normally found and the higner levels giving- clinical toxicity, fhese borderline cases may be of groat significance in the aetiology of mental retardation. I am of course familiar with your worn and already possess reprints of your aarben Lectures, these were mindly given to me by Jr. Camps. they have, of course, been a great source of interest. I agree with you that the possibility of lead poisoning is an extremely important one in industry and it is certainly of growing importance in paediatrics. I strongly agree that our aim must be to prevent the possibility of children receiving increased intakes of lead. Blank you very much for the interest you have taken. Xours sincerely Barbara A.Clayton, JuJ., IAR.C.P., Ph.D., Chemical pathologist. Copy to Prof, Air Alan Moncrieff. Dr. A. A..Aehoe, university of Cincinnati, College of Medicine, Aden Avenue, Cincinnati 19, Ohio. N14042 0012370