Document kaNaM7aV0ewbj8wvmG78znyzq

COPIED r MANUFACTURING CHEMISTS ASSOCIATION ^ 1825 CONNECTICUT AVENUE. N.W. WASHINGTON. D. C. 20009 (202) 483-6126 J ,CD MMSeptember 12, 1977 stpy9\977 TO: Vinyl Chloride Technical Panel SUBJECT: Updated Summary of Reported Cases of Angiosarcoma of the Liver Among Vinyl Chloride Polymerization Workers G ntlemen: Because of Dr. T, R. Torkelson's excellent liaison work on the maintenance of an international registry, Ms. Rose Kaminski has made available to him the most recent update on reported cases of angiosarcoma. Dr. Torkelson thoughtfully has requested that copies of these data be sent immediately to all Panel members. Your copy is attached. As is shown in the attached copy of Dr. Torkelson's letter addressed to Mr. John Lawrence and the undersigned, there exists a need for additional data to complete the record on new cases. Please cooperate with Dr. Torkelson in his efforts to have the registry be both complete and current. Sincerely, JTSsec Enclosure u. T. Seawell Project Manager Vinyl Chloride Research ASI 000012420 SEP 0 9 `W THE DOW CHEMICAL COMPANY BENNETT BUILDING 2030 DOW CENTER MIDLAND. MICHIGAN 48E40 September 7, 1977 John Lawrence Society of Plastics Industry, 355 Lexington Avenue New York, N. Y. 10017 Inc, J. T. Seawell Manufacturing Chemist Association 1825 Connecticut Avenue Washington, D. C. 20009 Gentlemen: Rose Kaminski, Statistician from NIOSH has kindly sent me an August update of their angiosarcoma registry. Ms. Kaminski asks some questions about new cases that I cannot answer. Will you please distribute this tabulation, calling attention to the need for additional data to complete the new cases? I have had excellent cooperation exchanging information with this NIOSH group and I encourage our membership to help them keep this registry. Sincerely, Corporate Medical Dept. Enclosure mh cc: John Stafford, PhD. Health & Environmental Prot. Plastics Division Imperial Chemicals Ind., Ltd. P.O. Box No. 6 Bessemer Road Welwyn Garden City Hertfordshire England AL7 IHD Rose Kaminski Illness Effects Section Surviellance Branch Division of Surveillance, Hazard Evaluation, and Field Studies NIOSH R. A. Taft Laboratories 4676 Columbia Parkway Cincinnati, OH 45226 ASI 000012421 DEPARTMENT OF HEALTH. EDUCATION. AND WELFARE PUBLIC HEALTH SERVICE CENTER f CH tURCESi CONTROL September 1, 1977 NATIONAL institute FOR OCCURATIONAL SAEETT AND HEALTH ROBERT A TAFT LABORATORIES 46TG COLUMBIA PARKWAY. CINCINNATI OHIO 4S226 T. R. Torkelson, Sc.D. Corporate Medical The Dow Chemical Company Bennett Building 2030 Dow Center Midland, Michigan 48640 Dear Dr. Torkelson: Thank you for the information concerning angiosarcomas associated with vinyl chloride in your letter of August 22, 1977 to Dr. Spirtas. We would like to obtain more details on the cases new to this office and would, therefore, appreciate any additional information you have on these, or better yet, the name and address of the person we could contact for more information. Also, to your knowledge, have these additional cases been microscopically confirmed? In regard to your question concerning the U.S. cases, you are correct about the name of case 18, and case 23 was employed at the Great American Chemical Company in Fitchburg, Massachusetts. In regard to German case 8, I have enclosed a copy of the documentation we have received concerning the German cases. Several weeks ago you mentioned correspondence among Drs. Philip Landrigan, Hans Popper, Louis Thomas and Marcus Key concerning the validity of U.S. cases 14 and 15. I was unable to find any such correspondence in our files. I telephoned Dr. Thomas and Dr. Falk in regard to this matter and it was agreed that case 14 should be removed from our lists. Dr. Thomas stated that case 15 couldn't be discounted as an angiosarcoma since it was microscopically confirmed but that a determination couldn't be made as to whether or not this angiosarcoma was VC induced. As a result, Table II will not be presented in the Current Intelligence Report we intend to submit to JOM. ASI 000012422 Page 2 - Dr. T. R. Torkelson Since I spoke with you last, two more U.S. cases have been reported to this office. I have enclosed a revised copy of Table I, which includes these cases, plus the additional cases you provided. Again, thank you for the information you have provided. Sincerely yours. Enclosure Rose Kaminski, Statistician Illness Effects Section Surveillance Branch Division of Surveillance, Hazard - Evaluations, and Field Studies ij i i ASI 012423 AUaiST, 1977 TABLE 1 REPORTED CASES OF ANGIOSARCOMA OF THE LIVER AMONG VINYL CHLORIDE POLYMERIZATION WORKERS COUNTRY BELCIUM CANADA CANADA CANADA CANADA CANADA CANADA CANADA CANADA CANADA CANADA CZECH. CZECH. FED.REP.CER. FED.REP.CER. FED.REP.CER. FED.REP.CER. FED.REP.CER. FED.REP.CER. FED.REP.CER. FED.REP.CER. . CASE NO. 01 01* 02* 03* 06* 05* 06* 07* OS 09 10 01* 02* 01* 02* 04 05* 07* 08* 09* 10 1ST VC SIXTH OR P\'C DATF. EXP. 00-00-00 00-00-00 12-15-13 00-00-44 03-06-14 00-00-43 03-26-19 00-00-41 04-05-19 00-00-45 05-07-11 00-00-44 12-15-19 00-00-47 11-09-19 05-13-20 07-19-21 00-00-46 00-00-61 00-00-46 05-16-15 00-00-53 00-00-28 00-00-57 00-00-26 00-00-51 06-04-30 10-01-56 07-26-31 10-14-57 09-04-30 04-16-57 01-01-32 12-16-62 09-29-26 04-15-54 10-19-17 04-19-54 12-13-34 12-02-59 AWAITING DETAILS DX ANCIOSARCOMA 00-00-00 00-00-55 00-00-57 00-00-62 00-00-67 00-00-68 00-00-71 00-00-72 00-00-73 00-00-74 00-00-76 00-00-73 00-00-66 09-19-68 09-25-70 00-00-74 00-00-75 00-00-75 00-00-75 06-16-76 ACE AT DX 00 41 43 42 48 57 51 53 53 53 61 46 40 38 40 44 43 49 58 42 YEARS TOT. 1ST EXP. YRS. TO DX EXP. 00 00 10 11 14 14 21 20 22 22 24 05 24 23 26 25 12 05 28 26 23 14 16 16 15 15 11 11 13 12 17 11 13 12 17 12 22 21 17 15 DATE OF DEATH 06-29-76 09-02-55 12-21-57 03-22-61 01-21-68 07-05-68 04-10-71 12-24-72 06-12-73 09-04-74 04-00-77 00-00-74 00-00-66 01-25-69 12-14-71 11-25-74 01-09-75 11-13-75 12-25-75 ALIVE FRANCE FRANCE FRANCE FRANCE FRANCE FRANCE 01* 04-15-24 01-00-46 02-18-67 43 21 02 06-03-11 07-06-59 01-08-75 63 15 03* 00-00-19 00-00-46 01-00-75 55 29 04* 01-27-27 10-19-49 01-04-76 49 26 05* 01-29-38 00-00-65 04-00-76 38 11 06* 04-14-34 00-00-58 09-00-76 42 18 19 02-19-67 12 01-24-75 29 06-29-75 26 01-04-76 10 05-13-76 17 09-12-76 FRANCE 07 00-00-27 07-01-50 07-00-76 49 26 23 07-02-76 FRANCE 08 00-00-00 00-00-00 00-00-00 00 00 00 01-30-77 GREAT BRIT. 01* 00-00-01 00-00-46 12-00-72 71 26 GREAT BRIT. 03 06-02-37 02-00-66 00-00-74 37 09 ITALY ,, 02* 11-13-29 00-00-57 12-13-72 43 15 20 12-00-72 04 12-24-74 06 12-00-72 ITALY JAPAN NORWAY SWEDEN SWEDEN 03* 03-14-20 00-00-53 07-10-75 55 22 01 08-01-22 04-00-53 08-21-74 52 22 01* 12-23-15 03-00-50 12-20-71 56 22 01* 06-23-27 08-14-51 02-00-70 43 19 03 AWAITING DETAILS 21 07-10-75 22 10-24-75 21 01-04-72 18 10-20-70 SWEDEN 04 AWAITING DETAILS U.S.A. U.S.A. 01* 10-17-23 12-09-48 03-03-73 49 22 02* 08-19-33 11-15-55 05-00-70 37 14 16 03-03-73 13 09-23-71 U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. . 03* 04* 05* 06* 07* 08* _______ 09* 05-25-15 11-28-45 12-19-73 58 28 01-15-24 07-06-52 08-19-67 43 15 0i-25-12 05-19-44 04-09-64 52 20 00-00-29 01-17-62 02-00-74 45 12 05-03-22 `08-27-44 00-00-68 45 24 05-06-20 10-07-46 08-00-61 41 15 11-08-31 09-09-54 03-01-74 43 17 28 12-19-73 15 01-07-68 18 04-09-64 12 07-24-75 18 03-23-68 15 08-29-61 17 03-00-75 U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. U.S.A. 10* 11* 12* 13* 16* 17* 18* 08-16-13 06-12-51 05-00-68 55 17 05-27-09 10-14-46 03-00-70 61 23 11-17-18 09-13-49 05-02-69 50 20 12-01-21 08-19-44 05-00-74 52 30 11-04-27 05-08-50 00-00-69 41 17 05-06-31 06-23-55 10-11-74 43 19 04-22-28 09-15-54 00-00-75 46 21 17 05-10-68 23 03-16-70 15 05-02-69 30 07-04-74 4 03-27-69 19 ALIVE 13 11-02-75 U.S.A. 19* 00-00-15 00-00-43 06-19-75 60 32 32 ALIVE U.S.A. U.S.A. U.S.A. 20* 08-31-17 00-00-55 01-30-76 58 21 21* 00-00-10 12-00-46 00-00-77 67 30 22* 10-02-23 00-00-49 01-00-76 52 27 18 01-30-76 22 01-02-77 27 12-04-76 U.S.A. 23* 00-00-23 09-08-58 00-00-00 50 00 14 04-06-73 U.S.A. 24* 00-00-17 00-00-39 05-27-77 60 38 26 05-27-77 U.S.A. 25* 08-07-10 09-00-47 03-10-77 67 30 20 03-10-77 .YUGOSLAVIA .YUGOSLAVIA 01* 04-05-14 00-00-53 04-08-73 59 20 02* 11-15-31 00-00-50 07-12-73 42 23 20 04-08-73 18 07-12-73 . Total reported case* " 63 * - Indicates microscopically confirmed angiosarcoma of the liver. "00" - Indicates unknown data. ASI 000012424