Document kZpkYOw6Ggg8bnre8aKznJ0n

MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE. N W. WASHINGTON, D. C. 20009 (202) 483-6126 August 13, 1976 TO: Vinyl Chloride Research Coordinators SUBJECT: Exposure Concentration Data For Long-Term Inhalation Study Gentlemen: The subject information is enclosed for your perusal along with cover letter of August 10 from Dr. Goode. Dr. Torkelson felt this topic should be discussed at the next meeting of this group which is still unscheduled. Sincerely, MF: ec Enclosure Milton Freifeld * Project Manager Vinyl Chloride Research URL 17070 VINYL CHLORIDE RESEARCH COORDINATORS Dr. Z. G. Bell, Jr. PPG Industries, Inc. One Gateway Center Pittsburgh, Pennsylvania 412-434-2585 15222 Dr. W. D. Harris UNIROYAL, Inc. EMIC Building Naugatuck, Connecticut 203-573-2000, ext. 2139 06770 Dr. M. N. Johnson The B. F. Goodrich Company Medical Center 500 South Main Street Akron, Ohio 44318 216-379-3298 Mr. H. L. Kusnetz Shell Oil Company Box 2463 Houston, Texas 77001 713-220-5604 Dr. W. M. Smith Air Products and Chemicals, Inc. P. O. Box 538 Allentown, Pennsylvania 18104 215-395-7215 Dr. T. R. Torkelson, Chairman The Dow Chemical company Corporate Medical Department 2030 Dow Center Midland, Michigan 48640 517-636-5197 Mr. R. N. Wheeler Union Carbide Corporation Chemicals & Plastics Division P. 0. Box 8004 South Charleston, West Virginia 304-747-2164 25303 TOXICOLOGY ENVIRONMENTAL SCIENCES CHE Ml 5TRY PLANT SCIENCES MEDICAL 5CIENCES 3ndLu&ucd BIO -TEST J?oJwiabyu6', 3nc DECATUR RESEARCH 1800 EAST PERSHING ROAD DECATUR, ILLINOIS 62526 August 10, 1976 AREA CODE 217 TELEPHONE 877-925-4 Dr. Milton Freifeld Project Manager Manufacturing Chemists Association 1825 Connecticut Avenue, N.W. Washington, D.C. 20009 Dear Milt: Enclosed are ten copies of the means for the 261 exposure days of the vinyl chloride study. The averages of these means are: 50. 15 ppm for T-I Target 50 ppm 200. 10 ppm for T-II Target 200 ppm 2465. 71 ppm for T-III Target 2500 ppm 24 67. 23 ppm for T- IV Target 2 500 ppm T-IV as you will recall, was the group allowed food and bedding during exposure. The concentration data are also available in the 7th and 18th month status reports on this project. If I can be of any further service to MCA, please do not hesitate to call me. Sincerely JWG/dm enc. w- Goode, Ph. D. Manager, Decatur Research Laboratories i.O U 'K tfi ro BIO-TEST )nc. TABLE TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Expos ure N umb e r 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 Mean Chamber Concentration Data TE-I Chamber Concentration (ppm) TE-II TE-III 43 173 48 181 50 207 51 87 52 218 57 194 53 199 56 164 58 242 62 186 60 202 60 156 58 207 59 162 47 160 49 211 60 219 51 201 50 214 62 242 58 219 56 265 46 220 45 106 51 212 47 203 55 225 52 184 43 209 50 209 52 180 48 177 44 215 50 200 54 217 2510 2548 2098 2540 2202 2401 2475 2555 2283 1770 2510 2653 1972 2544 2556 2391 2922 2356 2690 2488 1561 2567 2659 2855 2496 1899 2337 2587 2474 2141 2659 1920 2190 2002 2377 TE-IV 2355 2467 2261 2293 2330 2329 2675 1915 2192 2481 3236 2733 1664 1794 2545 2612 2531 2777 1969 2510 2488 2105 2295 2441 1655 1799 2998 3356 2686 2756 2891 2564 1920 2379 2213 URL 17073 JttcUdticl B I O - T E S T Ja6o*at&uU, $nc. TABLE continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Exposure Number 36 37 38 39 40 41 42 43 '44 45 46 47 48 49 50 51* 52 53 54* 55* 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 * No exposure Mean Chamber Concentration Data TE-I 60 50 38 45 49 53 54 56 63 52 53 119 84 52 32 - 48 49 - - 48 56 54 46 45 43 49 60 48 53 42 48 42 39 43 Chamber Concentration (ppm) te-ii te-iii 171 190 198 193 278 128 21 9 238 211 195 199 298 255 206 105 - 210 202 - - 196 347 243 218 240 191 210 185 211 214 172 209 216 190 199 2083 2451 2225 2208 2018 2686 2579 2835 2344 2640 1968 1659 2910 2498 2348 _ 2565 2516 _ _ 2445 2141 2404 2333 2229 2077 2380 1659 2246 2394 1963 2401 2722 2367 2448 TE-IV 2692 3307 3688 2638 2525 2310 2616 3203 1752 3149 2281 2569 1754 2573 1612 2528 2460 _ _ 2525 1576 2231 2306 2388 2306 2725 2457 2506 2428 - 2503 - 2328 2448 URL 17074 J+iduAt'ual B I O - T E S T J!&kyi&vue4; Due. TABLE continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Exposure Number 71 72 73* 74* 75 76* 77* 78 79 80 81 82* 83 84 85* 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 Mean Chamber Concentration Data TE-I Chamber Concentration (ppm) TE-II TE-III 29 277 36 256 -- -- 51 203 -- -- 46 247 43 235 44 201 42 211 -- 47 201 47 200 -- 45 199 44 184 54 173 44 295 46 175 47 197 51 200 50 230 53 201 53 220 68 230 38 186 41 172 50 222 35 187 46 189 49 202 48 222 51 205 49 196 3185 2499 - - 2585 - - 2397 2409 1448 2306 - 2385 2393 - 2565 2513 2664 3090 2396 2414 2191 2145 2883 2259 2624 2983 2410 2745 2354 2346 3100 2580 2546 2408 TE-IV 3516 2578 - - 2470 - - 2633 2464 2400 - - 2006 2176 2529 2390 1083 2377 2236 - - 2900 2333 2180 3513 2170 2875 2352 2046 2676 2306 2494 2542 * No exposure. URL 17075 J`rtduii^ueti B I O T E S T $nc. TABLE continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Expos ure Number 106 107 108 109 no 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131* 132 133 134 135 136 137 138 139 140 Mean Chamber Concentration Data TE-I Chamber Concentration (ppm) TE-II TE-III 30 193 50 220 49 200 44 193 59 198 52 216 50 198 54 222 58 200 54 195 57 203 46 202 49 197 50 184 53 187 48 213 49 192 48 197 38 198 49 197 54 211 53 195 48 195 53 210 50 198 -- 53 196 52 206 50 209 51 194 48 201 48 202 50 197 49 187 54 205 2393 2614 2566 2349 2497 2683 2573 2519 2392 2538 2592 2535 2922 2428 2529 2543 246 1 2708 2488 2505 2787 2739 2512 2671 2467 - 2452 2551 2419 2515 2575 2512 2462 2424 2537 TE-IV 2245 1946 2534 2529 2357 2700 2706 2467 2502 2408 2642 2360 2455 2361 2428 2564 2355 2347 2640 2543 3080 2551 2644 2657 2500 - 2453 2434 2480 2472 2753 2445 2440 2343 2590 * No exposure. URL 17076 y*tdtuifAiai B I O - T E S T ab&\atiyu&i. Doc, TABLE continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Exposure Number 141 142 143* 144 145 146 147 148 149 150 151 152 153 154 155* 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 Mean Chamber Concentration Data TE-I C hamb e r Concentration (ppm) TE-II TE-III 45 196 57 177 -- 49 223 48 197 51 218 47 207 49 223 52 193 51 200 47 189 48 194 48 197 52 206 -- 47 202 50 184 45 192 49 134 45 196 53 179 58 181 52 195 52 187 49 200 52 201 48 199 49 193 48 207 54 205 49 191 49 209 50 197 48 194 51 199 2535 2594 - 2561 2500 2552 2541 2613 2444 2627 2413 2583 2467 2459 - 2554 2457 2240 2540 2687 2384 2484 2580 2488 2583 2520 2479 2472 2932 2528 2487 2478 2468 2367 2487 TE-IV 2391 2440 _ 2480 2551 2352 2523 2352 2524 2654 2441 2435 2409 2493 - 2231 2294 2760 2600 2264 2664 2456 2815 2669 2755 2353 2667 2545 2729 2668 2488 2339 2532 2512 2496 * No exposure. URL 17077 {/.uhtdfrual B I O **T* E S T Jta&QSuziosii&i., 9*tc. TABLE continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhatation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Mean Chamber Concentration Data Exposure Number 176 177 178 179 180 * 181 182 183 184 185 186 187 188 189* 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 * 207 208 209 210* TE-I 49 51 51 49 - 51 50 57 51 48 49 50 47 - 48 50 51 51 50 47 48 50 49 50 48 48 48 50 53 50 - 49 46 49 _ Chamber Concentration (ppm) TE-IX TE-III 198 - 203 201 - 204 193 171 203 199 209 202 205 - 198 196 200 215 204 200 202 19-8 199 201 200 204 202 206 194 199 - 200 209 203 _ 2534 2618 2573 2645 - 2347 2396 2364 2501 2328 2397 2537 2400 - 2431 2350 2452 2633 2447 2439 2377 2386 2457 2585 2473 2515 2459 2550 2620 2504 - 2593 2482 2521 _ TE-IV 2536 2673 2640 ** - 2347 2464 2580 2355 2380 2392 2545 2524 - ** 2272 2400 2540 2270 2408 2440 2440 2564 2656 2672 2600 2413 2640 2478 2397 - 2528 2424 2516 - * No exposure ** No sample. URL 17078 ^ruiudi/Uai B I O T E S T ^aJuviat&ued, 9*tc. TABLE continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Exposure N utnb e r 211 2 12 21L3* 214* 215* 2 lb * 217* 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 Mean Chamber Concentration Data TE-I Chamber Concentration (ppm) TE-II TE-III 48 207 49 205 -_ 2577 2613 _ _ _ 48 218 49 204 42 203 46 185 51 193 51 184 43 160 44 174 54 208 51 205 49 192 49 201 52 210 55 208 51 204 50 196 54 202 -- 58 202 56 191 56 208 51 202 43 168 46 184 50 190 49 203 51 199 51 203 2288 2565 2481 2258 2380 2280* 1920 2073 2473 2558 2022 2542 2699 2475 2405 2597 2576 - 2540 2376 2300 2556 2481 2685 2366 2607 2420 2638 TE-IV 2428 2585 _ 2480 2445 2440 2410 2364 2440* 2800 2680 2480 * 2400 2640 2460 2333 2348 2 370 2576 - ** ** 2420 2084 2584 - 2380 2413 2428 2536 * No exposure. ** No sample. URL 17079 B I O T E S T JjaltaAal&iiM., !)*&. TABLE continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Mean Chamber Concentration Data Exposure N umb e r 246 247 248 249 250 251 252 253 254 255* 256 257 258 259 260 261 TE-I 48 50 50 51 - 40 44 59 59 - 44 56 51 50 47 52 Chamber Concentration (ppm) TE-II TE-III 195 203 200 197 213 228 219 207 199 - 225 206 202 206 204 197 2458 2525 2528 2422 2800 2783 2680 2490 2635 - 2654 2487 2602 2480 2597 2718 TE-IV 2467 2436 243.5 2375 2240 2176 2395 2372 2447 - 2460 2350 2512 2440 2730 2484 URL 17080 * No exposure.