Document kYY9D8N6rKgYpq9gwy4x801B

TN Ags 3M gene | Foo 3CMopMeedicTa DepgartmenY t P S AR 226- 0950 = iNAY 2 0F00- 373 ~ = aFnludoFriolcmhePmliacnatlEEmxpploosyuerees(Serum) Assessment of Decatur Chemical E Historically, employees a the 3M Decatur chemical plant have voluntarily participated in & biennial fluorochemical medical surveillance program: Total organic fluorine was measured until 1994 when perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) were assayed. However, the voluntary natureof the medical surveillance. program does not necessarily provide for an adequate understandingofthe distribution of fiyorochemical serum levels in the Decatur workforce. Therefore, the purpose ofthis assessment was 10 randomly sample employees at the Decatur chemical plant in orderto determine the distribution ofemployee serum fluorochemical levels according to jobs, building locations and years worked. The overall geometric meanof serum PFOS in g chemical plant employees was 0.944 ppm. (95% C1 0.787-1.126). The highest serum 88 PFOS value measured was 10.600 ppm. Among film plant employees, the overall = zz seometric meanofserum PFOS was 0136 ppm (95% CI 0.114-0.161). Approximately F 1/3 ofthese film plant employees had past work history experience in the chemical plant, The distributionofserum PFOS levels in this random sample assessment were similar to those observed through the voluntary medical surveillance program. Because of analytical chemistry method development, th study also assayed five fluorochemicals that had not been previously assayed. Results from this assessment will be used to consinict an exposure mix i the updated retrospective cohort mortality study ofthe 3M Decatur employee population. The data will also be used to rationalize subcohort $ EPA-oTE RGRAY 000811787u 001249 Pe------------------ - oo comparisons in the ongoing analysisofhealth claims data between chemical and film plant employees from 1993-1998. Both the study protocol and final report are submitted. 001250 3M Company EPL-0006 Page 1 of 29 PROTOCOL Epidemiology, 220-3W-05 Medical Department 3M Company St. Paul, MN 55144 Date: September 3, 1998 Title: Fluorochemical Employees Exposure Assessment of Decatur Chemical and Film Plant Study . Start Date: September 3, 1998 Estimated Date of Final Report: December31, 1998 IRB Approval Date: September 3, 1998 Protocol Number IRB Approval Exempt Expedited x Principal Investigator: Co-investigators: Geary W. Olsen, DVM, PhD' Perry W. Logan, MS? Cathy A. Simpson, RN Jean M. Burris, RN, MPH' Michele M. Burlew, M.S." John C. Schumpert, MD, MPH' Jeffrey H. Mandel, MD, MPH' Study Director: Jeffrey H. Mandel, MD, MPH 1. Medical Department, 3M Company, 220-3W-0S, St. Paul, MN 55144. 2. 3MEHS&R P.O. Box 2206,Decatur, Alabama 35609-2206 001251 ABSTRACT 3M Company EPL-0006 Page 2029 Employees at the 3MDecatur chemical plant have in the past voluntarily participated in a fluorochemical medical surveillance program. Analysis of the surveillance data has not shown significant associations between the employees' clinical chemistry and hematology tests and either total serum organic fluorine or serum PFOS levels. However, the voluntary nature of the medical surveillance program does not allow for a complete understandingofthe distributionof employee fluorochemical serum Tevels. In order to address this issue, we propose to randomly sample, for statistical purposes, 80 film plant and 125 chemical plant employees to determine their serum levels for perfluorooctane sulfonate, perfluorooctane sulfonate amide, glycine derivative of perfluorooctane sulfonate, perfluorohexane sulfonate, perfluorooctanoic acid, N-ethyl perfluorooctanesulfonamido ethanol and N-methyl perfluorooctanesulfonamido ethanol. A sub-sampleofemployees (N = 30) will also be tested for total serum organic fluorine. Abrief questionnaire will also be administered to each employee inquiring about current and past work history as well as possible routesoforal ingestion. In addition to those. chosen for the random sample, all other chemical and film plant employees will be offered the opportunity to have their blood tested for these fluorochemicals and respond to the questionnaire. Upon completion of this study, the results will serve as a reference regarding fluorochemical exposure reduction efforts in the chemical plant and allow for adequate characterization of the film plant population who will serve as a reference Population in health-based studiesof chemical plant employees. 001252 ' INTRODUCTION 3M Company EPI0006 Page 3 of 29 Employees at the 3M Decatur chemical plant have in the past voluntarily participated in a fluorochemical medical surveillance program. The surveillance program measured for total serum organic fluorine levels until themid-1990's when serum perfluorooctanoate sulfonate (PFOS) determination, quantifiable by high performance liquid chromatograph mass spectrometry, became incorporated in the biennial medical surveillance examinations. Analysis of the surveillance data has not shown significant associations between the employees" clinical chemistry and hematology tests and either total serum organic fluorine levels [Roach, 1982; Schuman, 1982] or serum PFOS levels [Olsen et al. 1998]. However, the voluntary nature of the medical surveillance program does not lend itself to an appropriate characterization of the distribution of fluorochemical serum levels. For example, presented in Table 1 is the distribution of fluorochemical serum levels by the numberof employees who voluntarily participated in the last two `medical surveillance examinations (Fall of 1994 and Spring of 1997). Ninety percent of the serum PFOS measurements were below 6 ppm. Nevertheless, it is possible that this distribution may be higher or lower as a result of unknown selection factors that make employees decide to participate, or not participate, in the medical surveillance program. `Therefore, the purpose of this proposal is to randomly examine, based on appropriate statistical methods, employees in the Decatur chemical plant in order to determine the distribution of their serum fluorochemical levels. Conducting a random sample analysis will also allow researchers to better understand serum fluorochemical levels in context with the employees' current and past work history. In addition, a random 001253 : 3M Company EPL0006 sample of the neighboring 3M Decatur film plant employee population, Page 4 0f located at the 20 same site. will also be tested for their fluorochemical serum levels. The film plant employees have served as a comparison population in prior health studies due to their nonoecupational exposure to fluorochemicals. However, their actual serum fluorochemical levels have not been discemed. Health studies can be more fully appreciatedif the distributions of employee serum fluorochemical levels at both the chemical and film plants are known. METHODS Overall Summary of Methods `We propose to randomly sample, for statistical purposes, 80 film plant and 125 chemical plant employees to determinetheirserum levels for perfluorooctane sulfonate, perfluorooctane sulfonate amide, the glycine derivative of perfluorooctane sulfonate (i.c., the acetate anion), perfluorohexane sulfonate, perfluorooctanoic acid, N-ethyl perfluorooctanesulfonamido ethanol and N-methyl perfluorooctanesulfonamido ethanol, A sub-sample of employees (N = 30) will also be tested for total serum organic fluorine. No other serum tests will be performed. A brief questionnaire will also be administered to cach employee inquiring about current and past work history as well as possible routes of oral ingestion. In addition to those chosen for the random sample, al other chemical and film plant employees will be offered the opportunity to have their blood tested for these fluorochemicals and respond to the questionnaire. `+ 001254 SampleSize Issues 3M Company EPL0006 Page Sof 29 Four critical factors were considered to decide the sample size for ths study. First, itis important that such a sample be randomly chosen from the employee populations of both the chemical and film plans. Second, the sample size is driven by the need to provide confidence that the exposure in the film plant is very small relative to that of the chemical plant. Third, the sample size should adequately characterize the exposure levels within the chemical plant workplace. Fourth, employees in the chemical and film plant shouldbeoffered the opportunity to know what their luorochemical serum levels are To address the first two points in the above paragraph, we need to determine the. lower 95% confidence bound on the mean of the difference between the serum fluorochemical levels ofthe chemical plant and the film plant. Provided in Appendix A are the details of the methods used by Dr. Timothy Church, associate professor at the University of Minnesota, who served as a consultant statistician for this protocol development. Briefly, we assumed, based on past medical surveillance data, that the mean serum PFOS levels of the chemical plant employee population is 1.85 ppm. We do not know what the mean serum POS level isoffilm plant employees. However, pooled serum data suggests that the US. general population serum PFOS level is in the range of 20 pb 10 40 ppb. Therefore, we assumed theDecaturfilm plant population will have a mean higher than the general population because of its physical proximity to the chemical plant. If the mean serum PFOS level for the film plant population was assumed to be: 200 ppb. the mean difference between the chemical and film plant population would be 001255 3M Company EPL-0006 1.65 ppm (1.85 ppm minus 0.2 ppm). Presented below is the sample size Page needed 6 of from 29 both the chemical and film plant populations to calculate a lower 95% confidence bound on this mean difference. L`oTowtealrs9a5mp%lecoSnifziedneenecdeebdofurnodmobnotdihffpelranetnsc:e: 12 16 13 21 14 32 15 66 155 16 121 365 Thus, to obtain a lower 95% confidence bound of 1.50 ppm, based on a mean difference. of 1.65 ppm, 33 employees in the film plant and 33 employees in the chemical plant will have to have their serum PFOS levels determined. As canbe seen from the above chart, the sample size becomes increasingly large as the lower 95% confidence bound becomes closer to the actual mean difference of 1.65 ppm. Data in Appendix A also provide sample size calculations if the film plant employee population is assumed to have a higher mean serum PFOS level (300 ppb). In this case, to obtain a lower 95% confidence bound of 1.50 ppm, based on a mean difference of 1.55 ppm (1.85 ppm minus 300 ppb), a total sample size of 760 employees is required from both plants.If this is reduced to a lower 95% confidence bound of 1.4 for a mean difference of 1.55 ppm, a much smaller sample size is required (a total of 125 employees from both plants). There is a degree of uncertainty in estimating, for statistical sample size consideration, what the mean serum PFOS level of the film plant population is because approximately 10 percent of the film plant employees may have prior work experience in the chemical plant. In order to address the third issue (sample size should adequately characterize the exposure levels within the chemical plant workplace), we propose to stratify the random 001256 ' 3M Company EPL-0006 sample by building location within the chemical plant. To prevent misclassificPaatgieon7of0f 29 potential workplace exposure experience, we will analyze samples from film plant employees by those who have and have not ever worked in the chemical plant. This is necessary because of the suspected long half-life of serum PFOS (estimated to be at 1000 days). An important caveat that must be considered is that the above sample size calculations have used serum POS levels from previous voluntary samples to estimate mean and standard deviation values for serum levels of this chemical. However, in this study we will measure for five specific fluorochemicals (perfluorooctane sulfonate amide, the glycine derivative of perfluorooctane sulfonate, N-ethyl perfluorooctanesulfonamido ethanol and N-methyl perfluorooctanesulfonamido ethanol) about which we have no. information, at this time, as to serum levels. It is suspected that these chemicals are not persistent as theyare metabolized to PFOS; thus any difference between serum levels in employees in the film and chemical plants may be quite small, Study Design `With the above issues considered, the study investigators propose the following research design: 1. Randomly sample 80 film plant employees. We will assume 80% participation which will provide a study population of approximately 65 employees of which we estimate 50 1055 will have worked only in the film plant. The remainder will have worked in both the 001257 ' 3M Company EPL-0006 chemical and film plants. (This is based on the assumption that 10 percent of Page 8 of Decatur 20 employees have worked in both plants as mentioned by Decatur Human Resources personnel.) The random sample will be chosen by the following means: a) determine all full-time current film plant employees; b) using a random number generator algorithm, select a sample size of 80 film plant employees. 2. Randomly sample 125 chemical plant employees who are proportionately stratified by the following building locations: 1, 2/48, 3,4 and 38/51. We will assume 80% participation which will provide a sample size of approximately 100 employees. The random sample will be chosen by the following means: a) determine all full-time current chemical plant employees; b) usinag random number generator algorithm, select a sample size of 125 employees proportionately to the number of employees who work in the five building locations (1, 2/48, 3,4 and 38/51). This random sample of 80 film plant and 125 chemical plant employees, if 0% participation is obtained, should provide 295% lower bound confidence interval of, atleast, 1.5 ppmif the mean PFOS difference is 1.65 ppm based on assuming the mean employee serum levels are 1.85 ppm for the chemical plant and 0.2 ppm for the film plant. 3. In addition, to the above random samples; we propose to sample all employees (n = 68) who are assigned to the wastewater treatment plant (buildings 36 and 57). 001258 3M Company EPL-0006 4. Because of concems that may be raised by this study, we will also offer to Page 9 test all of 29 full- time chemical or film plant employees who desire to know their serum levels of these seven fluorochemicals. S. Study participation will require the following: a. Venipuncture with the collectionofone vialof blood (approximately 10 cc) for the determinationofihe seven fluorochemicals. Its anticipated that total serum organic fluorine can also be determined from the same one vial of blood for the 30 individuals who are asked to participate in this analysis. b. Written response to abrief questionnaire that inquires about current and past work history along with the frequency of hand washing and use of gum, chew (tobacco) and cigarette habits of the employee while at work (see Appendix B). c. A signed consent form by the employee (see Appendix C). 6. Each randomly chosen employee (film and chemical) wil receive a leer of invitation to participate by plant management. A copy of this letter will be sent to the employee's immediate supervisor. There will also be plant-wide communication which will describe the purpose of this blood collection program (i.e. to determine the distributionof employee serumlevelsof these fluorochemicals and allow employees to 001259 i ' 3M Company EPI-0006 know their own individual values should they so desire). ~All study Page 10.0 participants who 29 are randomly chosen as well as those who volunteer will be informed of their own individual results by a letter sent to them from the 3M Medical Department. Aggregate results of the study will be communicated to plant management and employees. Eluorochemical Analyses All blood wil be collected at the Decatur plant by MedAccess (an occupational health clinic located in Decaiur, Alabama) under the direction of Cathy Simpson, RN. Based on this study design and the four employee shifts at the Decatur location, it is estimated that blood collection will take approximately four days. MedAccess will centrifuge the blood to obtain the serum. MedAccess will provide the serumtoCathy Simpson, RN who will ship the samples to the 3M Medical Department (St. Paul, MN). Samples will be catalogued and then sent to the 3M Environmental Laboratory for determination of serum perfluorooctane sulfonate, perfluorooctane sulfonate amide, glycine derivative of perfluorooctane sulfonate, perfluorohexane sulfonate, perfluorooctanoic acid, N-ethyl perfluorooctanesulfonamido ethanol and N-methyl perfluorooctanesulfonamido ethanol, via high performance liquid chromatography mass spectrometry, under the direction of Dr. Kris Hansen. Total serum organic fluorine will be determined by the 3M SMD chemical analytical laboratory under the direction of Dr. Venkateswarlu Pothapragada. 001260 Data Analysis 3M Company PageEP1I1-00f02096 Through the use of appropriate statistical techniques (c.g. student t-tests, multivariable regression analysis) using SAS software, we will conduct the following analyses: 1. Compare responders and nonresponders from those chosen in the random sample as to their demographic characteristics (e.g. age, gender, years worked) 2. Compare mean serum fluorochemical levels between the film and chemical plant random samples. Determine the lower 95% confidence bound of the mean difference between these populations. 3. Compare the mean value between the film plant and the chemical plant population Who participated (random sample plus those who are not part of the random sample). Determine the lower 95% confidence bound of the mean difference between these populations. 4. Characterize and compare the mean fluorochemical serum measurements within the chemical plant by building location. : S. Compare serum levelsby questionnaire items (e.g., examine mean serum fluorochemical levels of those who may have frequent hand to mouth contact via the ' 001261 ' 3M Company EPL0006 compilation of their use of gum, chew and cigarettes to those who do not Page 12 0f have frequent 29 use). It should be noted that this study is purely an exposure assessment exercise; medical surveillance information (e.g. serum chemistries, hematology, health questionnaires) is not a component of this study. This information is voluntarily collected on a biennial basis and will be next offered, voluntarily, to Decatur chemical plant employees in the Spring of 1999. StudyTimeFrame ProStp udyoTis meFerad me Task. Estimated Time Frame 1. Obtain current employee list fromDecaturHR August, 1998 2. Determine random samples August, 1998 3. Send invitation letter to participate to random sample September, 1998 4. Blood collection Sept/Oct. 1998 5. Serum analyses under direction by 3M Env. Lab Serum analyses under direction of Dr. "V* Oct. - Nov., 1998 Oct. - Nov. 1998 6. Data Analyses Nov. - Dec., 1998 2. Final report Dec. 1998 001262 DISCUSSION 3M Company EPL0006 Page 13 0f 29 `The objectiveof this proposed research study is to characterize , via appropriate statistical techniques using random sampling, the distribution of employee serum levels of serum perfluorooctane sulfonate, perfluorooctane sulfonate amide, glycine derivative of perfluorooctane sulfonate, perfluorohexane sulfonate, perfluorooctanoic acid, N-cthyl perfluorooctanesulfonamido ethanol and N-methyl perfluorooctanesulfonamido ethanol at the 3M Decatur chemical and film plants. In addition, for30 employees the percentage ofserum total organic fluorine that is represented by these seven fluorochemicals will be calculated. `The data obtained from this exposure assessment investigation will be important for several reasons. This information will allow for a better understanding of the exposure distribution of serum fluorochemical levels in both the chemical and film plant populations. Second, these data may serve as future reference regarding human exposure assessment for the film as well as the chemical plant in the area of health studies and exposure reduction. Third, the datamaybe used for the constructionofan exposure matrix for the anticipated update of the retrospective cohort mortality study of the Decatur employee population. Fourth, this information may provide further insight regarding understanding current fluorochemical serum levels with past and present employee work history data as well as possible routes of oral ingestion. Finally, this study will allow for the opportunity for chemical plant employees to know their own serum levels for these seven fluorochemicals should they so desire. 001263 i 3M Company EPI-0006 The greatest limitation to the success of this study is employee Page 14 participation of 29 Because random sampling is critical to the ultimate interpretation of the results from this study, it is important that there be high (i.c., 80%) participation levels from those chosen 0 participate. It must be emphasized that data analyses will be dependent upon high participation of those chosen in the random sample; nonparticipants will decrease the sample size. Although other employees may volunteer to have their blood drawn, they cannot replace a nonparticipant in the random sample within the data analyses devoted to the random sample component of this study. In order to obtain high participation rates of those employees chosen in the random sample, letters of invitation will be sent to those: chosen to participate by 3M Decatur plant managementandthe 3M Medical Department. Supervisors will be asked to strongly encourage participation of those randomly chosen employees who report to them. Individual data are considered confidential information and will not be disclosed to anyoneoutsidethe 3M Medical Department without the employee's written consent. Individual results will be communicated, by letter, to the employee from the 3M Medical Department. Aggregate findings will be communicated to employees and may be used in publications or public presentations. `The proposed study must obtain 3M IRB approval. The protocol, any addenda to the protocol, data analyses, and a copy of the final report will undergo a Quality Assurance audit according to the Standard Operating Procedure entitled, "Procedure for the Creation, Auditing, and Review and Approval of 3M Epidemiology Final Reports. Permanent records of all other data generated during the course of this study are subject 001264 3M Company EPL-0006 to privacy and confidentiality considerations. All data gathered or generatedPiangcelu1d5inogf 29 protocol addenda and the final report will be archived by the Medical Department, 3M Company, St. Paul, Minnesota, according to the Standard Operating Procedure entitled, "Procedure for the Archiving ofa 3M Epidemiology Study." 001265 3M Company EPL-0006 Page 16 0f 29 REFERENCES Roach DE (1982). Company:St. Paul, Fluorochemical Control MN May 25, 1982. Study. 3M Unpublished Report. 3M FSlcuhourmocahnemLiMcal(1C9o8n2t).rLoletStteurdty.o Dr. Frank April 29, Ubel 1982. (3M Medical Director) concerning OcllisneicnalGcWh,emBisutrrriiessJ,Mh,eMmaantdeollJoaHg,nydZohboerlmLonRes(1i9n98r)e.latAinonetpoisdeemriuomlloegvieclsinovfestigation of pUenrpfulbuloirsohoecdtaRneepsourltf.ona3tMe iCnommaplaenyf:lSuto.roPcahuelm.i,cMaNl.p,roAdpurcitli2o2n,em1p99l8o.yees. 3M 001266 TABLE | 3M Company EPI-0006 Page 17 of 29 Distribution of Serum PFOS Levels by Year, 3M Decatur Male Employees, Medical Surveillance Results PFOS Level 0-<1ppm 1-<3ppm N 1994 Data % i 2 59 66 3-<6ppm "16 18 >=6ppm Total 4 4 8 100 * see reference Olsen et al (1998) 1997 Data N % 29 35 38 45 12 14 5 6 84 100 001267 APPENDIX A 3M Company EPI-0006 Page 18 of 20 001268 3M Company EPI-0006 Page 19 of 29 Sample size calculation for the study of PFOS levels in the blood of workers Authored by Dr. Timothy Church Introduction The sample size calculations are based on the analysis of data from a non-random voluntary sample from the chemical plant in Decatur. There was a total of96 observations on PFOS levels and 95 on PFOA levels. Table 1 gives the summary statistics on each distribution. Table 2 gives the summary of the log distribution. Figures 1 and 2 are the smoothed natural distributions for PFOS and PFOA,respectively, and Figures 3 and 4 are for the logarithmic counterparts. Note that the log distributions are more symmetric that the natural scale variables. The sample size focused on the. PFOS levels. Method `The sample size is driven by the need to provide confidence that the exposure in the film plant is very small relative to that of the chemical plant. As shown in Table 1, the mean PFOS level in the voluntary samples is 1.855ppm and the acceptable level for the film `plant is below that and expected to be in the range 200-300ppb. The statistic of interest for the sample size is the difference between the chemical plant (assumed to have a mean of 1.855ppm) and the film plant (assumed to have a meanof 0.2-0.3ppm). The object is 10 compute the sample size necessary to produce 95% confidence that the difference is at least delta, in order to place the film plant mean exposure well below that of the chemical plant. If such confidence does not result, then further study of the film plant exposures is `warranted. `The sample size calculations were carried out by assuming that the log of the concentration was normally distributed, based on Figure 3, and that the standard deviation oanndthPeFlOoAg,scwahlielewassho1w,irneggadridflfeesrsenotfmteheanmevaanl,uebsa,sbeodthonhaTvaeblaes2t.anNdoatred dtehavtiabtoitohn PofFOabSout 1, even though the means and medians are quite different In order to perform the analysis on the log scale, the means had to be transformed to the log scale, by solving the formula E(O=exp(mutsigma'l2), for mu where E(X) is the mean on the original scale, and mu and sigma = 1 are the mean and standard deviation on the log scale. For example, under the assumption that the natural meanis 0.2ppm the mean for the log PFOS level in the film plant would be In(0.2) - sigma'/2 = -2.10944. `Transforming the means to the log scale allows computation of the expected difference in the lon erate and a lnwer 95% confidence bound on the difference. The difference on the 001269 3M Company EP1-0006 Page 20 of 29 log scale centers on mu, -- muy and the variance of the difference is simply 2/n, where mu, and muy are the means for the chemical and film plants, respectively, and is the number ofobservations per plant. Under the null hypothesis, the mean on the natural scalefor the film plant is the observed mean of the chemical plant (1.855ppm) minus the minimum desired difference (e.g., delta = ppm). Under the altemative hypothesis it is simply either 0.2ppm or 0.3ppm. The mean for the chemical plant is fixed at 1.855ppm for both the null and altemative hypotheses. By this formulation, the altemative hypothesis is the difference of the tranformed altemative-hypothesis means (.g., 1.855ppm and 0.2ppm) and the null hypothesis is the difference of the transformed null hypothesis means (i.., 1.855ppm and (1.855-- delta)ppm). From this formulation, a standard single-sample, two-sided, normal-theory sample size can be calculated, using alpha = 0.5 and beta = 0.05. If the minimum difference is rejected in favor of the alternative, the confidence coefficient on the `minimum difference delta wil be at least 95%. `Standard sample size calculations were performed using S-Plus 4.5 and the transformed `means, and sigma = 1. Results `Table 3 gives sample sizes based on the lower 95% confidence bound for the difference in mean PFOS level between the chemical plant and the film plant being at least dela. Sample sizes were calculated assuming means of 200ppb and 300ppb for the film plant. For 300ppb the sample sizes are given with delra equal to 1.0 through 1.5ppm in 0.1ppm steps, and for 200ppb, with delra equal to 1.2 through 1.6 and to 1.55. Sample sizes given are the sum from both plants assuming equal samples from each, i.c., the table gives N `where N=2n;=2n;, where n; is the sample from planti = film or chemical. So, for example,if the film plant has a true level of 200ppb, then the expected lower confidence bound on the difference would be 1.55if the total sample size were 122, 61 from each plant. Recommendation A lower confidence bound of 1.55ppm, which would assure that the film plant has an upper bound of 300ppb (or about 0.5ppm)if the true concentration were 200ppb, is achievable with 125 from both plants. Ifthe true concentration were 300ppb, a lower bound of 455ppb could be attained with a similar sample size. Given that nearly 100 volunteers were obtained previously, this also seems like a feasible number of employees in whom to focus solicitation efforts. 001270 Table 1. "** Summary Statistics for data in: Min: 0.10p0r0o0s 0.05p0r0o0a 1stMQeaun:: 01..8659510215 0.38900 1.32894 3MreddQiua.n:: 21..4382255000 11..8076000000 TotalMaxN:: 969..0903000000 965..0301000000 StdDWAe'vs.:: 01..0703070203 11..0008050705 DecExp97 e+ Table 2. + Sumary Statistics for data in: Min: L-o2g..30P2R5O9S Lo-2g..9P95F7O3A 1stMQeua.n:: -00..2326896380 --00..9142411286 3MreddQiuan.:: 00.3208912365 00..6025588217 TotalMaxN:: 926..209050506 91..0606090509 StdWDAe'vs.:: 00..0503031000 11..0000900020 DecExp9? e+ 3MCompany EPI-0006 Pa21gofe29 001271 3M Company EPI-0006 Page 23 of 29 Table 3. Sample size table for Decatur Plant Study Assumingfilm plant concentration = 300ppb Lower 95% Confidence Bound on Difference: ~~ 10 1.1 12 13 Total sample size for both groups (N=2ny=2n;): 20 26 36 58 Assuming film plant concentration = 200ppb Lower 95% Confidence Bound on Difference: 12 13 14 15 Total sample size for both groups (N=2n,=2nz): 16 22 32 66 14 1S 126 760 155 16 122 366 001273 ! APPENDIX B 3M Company EPI-0006 Page 24 of 29 001274 3M Company EPI-0006 Page 25 0f 20 DECATUR EMPLOYEE QUESTIONNAIRE aTnhankinytohuefaorpppraorptirciiaptaetibnogr.in this research study. Please respond to each question with either a shortansweror nae EMPLOYEE NUMBER. 1. Have you verworked in the Chemical Plant? Yes O No OJ If no, please go to question 2 yes a. How many years haveyouworked inthe chemical plant? Years=. b. What year did you startworking inthechemical plant? Year = 2. Please indicate if you have ever worked in the following areas. Mark an in al boxes that apptolyoyu. O a Building 1 0 b. Buidings 2 andlor 49 Oc. Buiding 3 (OSCLIOSF area) 0. Buiking3s (besides OSCLIOSF area) 0 e. Buiin4g North Ot. Biking 4 milloom/extruder Oo. Building 42 (Packaging FC inertsJ) h. Film Plant Oi. Wa(Bsutielwdiantgesr3t6reaantdme5n7t)plant C1}. Other (Please specify) 3. `Tahnisnwkeirngthaebofoultlotwhienjgoqbtuehsattiyoonsu.worked for the lopnerigodofetimsewhtile employed at 3M Decatur, please a dobre 000000 b. When did you work there: From___(year) to___(year) .. Average number of hours per week on tis ob? Hours =. d. When you worked overtime, what was your usual job assigament?_______ 001275 3M Company EPL-0006 Page 26 of 20 4. Please answer the folowing questions regarding your current ob. Current plant: Current job tie Chemical [J Fim 0 What year did you start working in this current job: Year= ______ `Average number of hours per wok on this job: Hours = When you work overtime, whatisyour usual ob assignment? 5. Pleas indicate in which area(s)youwork inyourcurrentjob. Mark an * in all boxesthatapply to you. OJ a. Buidin1g [0 b. Build2ianndglosr 49 0 c. Buiding 3 (OSCLIOSF area) 00d. Building3s (besides OSCLIOSF area) OJ e. Buiding 4 North O01. Building4s milroom/extruder 0 g. Bui42d(Paicknagigng FC inertsJ) h. Fim Plant Oi Wa(sButiolwdaintgesr3t6reaantdme5n7t)plant J. Other (Please specify) 6. While at work, do you chew gum? Damas O frequenty [J sometimes [J rarely [1 never 7. While atwork, Go youchew tobacco? O aways [Jtrequenty [J sometimes [J rarely [J never 8. While at work, do you smoke cigarettes? Oaways OO frequenty [J sometimes [J rarely [J never 9. How frequentlydoyou wash you hands before eating while in the workplace? Mark only one box. DO aways [J trequenty [1 sometimes [J raraly [J never 10. Whats your height? 11. Whatis your weight? Foot= Pounds = Inches =____ 001276 APPENDIX C 3M Company EPL-0006 Page 27 of 29 001277 : 3M Company EPI-0006 Page 28 of 29 CONSENT FORM FOR COLLECTION OF BLOOD FOR SERUM FLUOROCHEMICAL LEVEL DETERMINATION INTRODUCTION You are being invited donating one test tube to of participate in blood. Your a research blood will study. Your participation involves only be tested for the amount and kind orfevfileuwortohicshecmoincsaelnst iftocronmtcaairnesf.ulNlyoaontdhebretessutrsewyiollurbqeupeestrifoonrsmeadreoannysowuerrebdloboedf.orePlyeoause amnaskweera adnecyiqsuieosnttioonpsarttihcaitpyatoeu. mTahyehpalvaentanbuoruste,thCisatshtuydyS.impson, RN, will be available to PURPOSE OF STUDY `fTohuenpduirnpowsoerkoefrtshaetstthuedyDeicsattoudreptlearnmt.ineThhioswimnfuocrhmaatniodnwwhialtl tasyspiessto3fMfltuoorbeotctheermicals are understand. fluorochemicals and how to reduce such exposures in the workplace. SYToUurDbYlPooRdOwiCllEbDeUdRraEwSn with a needle stick and require one tube (10 ml) of blood. The pbelrofolducwirlolocbteanaenasluylfzoendaftoerasmeivdeen, ftlhueogrloycchienmeicdaelrsi:vapteirvfelouforpoeorcftlaunoersouolcftoannaetes,ulfonate, eptehrafnlouloraonhdexNa-nmeetsuhlyflonpaetref,lpueorrfoloucotraonoecstualnfooincaamciidd,o Net-heatnhoyll.pAerfsluubo-rsoaomcptlaenoefsuelmfpolnaomyiedeos wyiolulrabllsooodb.e tAestleetdtefrorwitloltablesseernutmtoorygoauniicnfflouromriinneg.yoNuoooftyhoeurrtbesltosowdilllebveelspeurpfoonrmed on `ceommpplloeyteieonionqfuitrhienagnaalbyosuets.cuArrberniteafnqdupeassttiownonraikrheiwsitlolryalassowbeellaadsmipnoissstiebrleedrtoouteeascohf oral ingestion. PTOhTeEoNnlTyIdAiLscRomIfSoKrtS/yBoEuNmEaFyIfTeeSl is from the needle stick. You may also have some temporary redness/bruising/swelling in this area after blood collection. BENEFITS iTnhfeorremawtililonbeganioneddirfecrtombetnheifsitstfurdoymwiylolurfupratrhtirchipealtpiouns iunndtehrsssttaunddy.huHmoawneveexrp,ostuhrees to fluorochemicals. overall findings, wYitohuorutinadniyvisdpueaclifriecsuelmtsplwoilyleebeidceonmtmifuyniincgaitnefdortmoatyiooun,onwliyl.l The be study's communicated to all Decatur employes. 001278 3M Company PageE2P9-0of00269 ICfOyMouPEsuNffSerATinIjuOryNor a medical condition that appears to be the result of participating in tthhiesesvteundty,ofyoaurewislelarbceh rreefleartreedditnojuarny,otchoemrpheenaslatthicoanrewiplrlofbeessdieotnearlmaitnendoocnosatctaosyeoub,y cIanse basis 8670, by of 3M. The contact for medical the 3M Medical Department. compensation is Jeffrey Mandel, M.D., 612.733. CONFIDENTIALITY p`Trheeseonvteartailoln.resYuolutsrcnoallmeectweidllinnothtisbestruedvyeamlaedy ibneaunsyedpuibnlipcuabtliiocnatoironosthoerr pduobcluicments yinotueonndleyd.fYooruprubilnidciavtiidounaelxraemsiunlatstiwoinll. bYeoucornisniddievriedduaclonrfeisduelntstiwailllinbfeorcmoamtmiuonniacnadtewidlltonot bedisclosed to anyone outside the 3M Medical Department without your written consent. ISfUyBouJEhCavTeRaInGyHqTueSs/tAioVnAsIaLbAouBtItLhIeTsYtudOyFnIowN,FoOrRlMatAerT,IoOr Nin the event of a research Mrealnadteedli(n6j1ur2y-7o3r3e-m8e6r70g)e.ncyF,orcoanntsawcetrCsattohqyuSeistmiposnosn,abRouNt (y5o5u2r-r6i3g4h1ts)oirnDrre.garJedftforetyhis research, you 733-5181. may contact Dr. Larry Zobel, Chair, 3M Institutional Review Board at 612- VOLUNTARY Participation in PARTICIPATION AND WITHDRAWAL this study is voluntary. Refusal to participate will involve no penalty or sltosusdyofatbeanneyfittismteofwohriacnhy yreoausaorne. otherwise entitled. You are free to withdraw from the SUBJECT CONSENT rBeyadsitghnisincgontsheenctonfsoernmt, faonrdm,thIacterhtaifvyetbhaeteInagmiveatnlaedaestqu1a8teyeoaprpsoorltdu.niItcyotnofaisrkmatnhayt I have u`qnudeesrtsitonasndI tmhaeyschoapvee oafbomuyt tphairsticcoinpsaetniotnfionrtmhiosrstthuedys,tuadyn.d tIhaatlsaollcoofnfmiyrmqutehasttiIons have 0beepnaratincsiwpeatreedinttohmeystsuadtyi.sfaIcutniodne.rs1taanmd stihagtniInagmthnisotcownasievnitngfoorrrmelveolausnitnagrialyn,yaonfdmIydelseigrael wriilglhtrsebceyisvieganicnogptyhiosfctohnissesnitgnfeodrmc,onosrebnyt participation form. in this study. I understand that 1 Signature Printed Name Date 001279 i -- FINAL REPORT Epidemiology, 220-3W-05 Medical Department 3M Company StPaSu 544lMN Title: Fluorochemical Employees Exposure Assessment of Decatur Chemical and Film Plant Final Report Date: August 11, 1999 Study Start Date: September 3, 1998 Protocol Number: EPI-0006 IRB Approval (#98082) Exempt: Expedited: X IRB Approval Date: Sepiembe3r, 1998 Study Archive Number: ARCH-021 Principal Investigator: Co-investigators: Geary W. Olsen, DVM, PhD! Perry W. Logan, MS* Cathy A. Simpson, RN? Kristen J. Hansen, PhD Jean M. Burris, RN, MPH' Michele M. Burlew, MS' John C. Schumpert, MD, MPH' Jeffrey H. Mandel, MD, MPH' Study Director: Jeffrey H. Mandel, MD, MPH 1. 3M Medical Department, 220-3W-05, St. Paul, MN 55144-1000 2. 3M Decatur, EHS&R, P.O. Box 2206, Decatur, Alabama 35609-2206 3. 3M Environmental Laboratory, 2-3E-01St,. Paul, MN 55144-1000 001280 EpLooa0ms Page 20185 QUALITY ASSURANCE STATEMENT FTiIlTmLPElaOnFt ESmTpUlDoYy:eesFluorochemical Exposure Assessment of Decatur Chemical and GTuhiedealbionvees sftourdGyowoadsEepxiadmeimnieodlofgoyr qPuraalcittiyceasssfuorraOnccceupinatkieoenpailnganwditEhntvhiersopmireinttoaflThe EEppiiddeemmiioollooggiycTRaesskeaGrrcohupa.s pTuhbelifsihneadl rbeypotrhte wCahsemdiectaelrmMianneudfatcotbuerearnsaAcscsuorcaitaetrieofnlection boefltohwe. data obtained. The dates of Quality Assurance activities on this study are listed Study Initiation Date: 09/03/98 Study Completion Date: 08/11/99 TYPE OF AUDIT: | DAAUTDEIOTF|| DRAETPEOFRITNEDDINTGOS| FIDNADITNEGS INPVREISNTCIIGPAATLOR| REPOR3TMED TO ADNIDRSECTTUODRY | MANAGEMENT APrdodteoncdola,,DDraatfat PFirloet,oDcroalft 06728159 06728795 06728759 Final Report (EinalRepon | 08/09/99 | 08/0999 | soo eAprcihdievmiinog:logAylarrcahwivdeastyasatnedm.the final report will be fled in the Occupational Medicine Signatures (and date) ofQA Audit Team Fpusse dlink lil17 Loire APopsy. 8/ajag 001281 EPLO03OmG Page 3 of85 ABSTRACT In the past, employees at the 3M Decatur chemical plant have voluntarily participated in a fluorochemical medical surveillance program. ~ Analysis of the. surveillance data has not shown significant associations between the employees' clinical chemistry and hematology tests and either total serum organic fluorine or serum PFOS (perfluorooctane sulfonate) levels. However, the voluntary nature of the historical `medical surveillance program did not provide for a complete understanding of the distribution of fluorochemical serum levels in the Decatur workforce. Therefore, the purpose of this study was to collect data by randomly sampling employees in the Decatur chemical plant inorderto determine the distribution of employee serum fluorochemical levels according to demographics, current and longest heldjobs, years worked and building locations. In addition, a random sample of the neighboring 3M Decatur film plant employee population, located at the same site, was tested to determine fluorochemical serum levels in order to characterize the differences between the two. plant populations. A total of 232 employees was randomly selected for serum sampling: 186 (80%) participated in the blood collection which occurred in the Fall, 1998. An additional 77 employees requested blood testing for the determination of fluorochemical levels. Of the. random sample of employees who participated, 126 were from the chemical plant and 60 from the film plant. There were 61 volunteers from chemical and 16 volunteers from film; thus, all chemical participants numbered 187 employees and all film participants numbered 76 employees. At the time of blood collection, employees responded to a twopage questionnaire that inquired about their current and longest heldjobs, the buildings 001282 EPLO03OMG Page 40785 they had worked in(if chemical employees). and possible routes of oral ingestion of fluorochemicals through cigarette smoking, chewing gum, chewing tobacco and hand washing practices. Sera samples were extracted using an ion-pairing extraction procedure. The extracts were quantitatively analyzed for PFOS (perfluorooctane sulfonate), PFHS (perfluorohexane sulfonate), POAA (perfluorooctanoic acid), PFOSAA (N-ethyl perfluorooctanesulfonamido acetate) PFOSA (perfluorooctane sulfonate amide), MS70 (N-methyl perfluorooctanesulfonamido acetate) and M556 (perfluorooctanesulfonamido acetate) using high-pressure liquid chromatography/electrospray tandem mass spectrometry (HPLC/ESMSMS) and evaluated versus an extracted curve. PFOS, PHS, POAA, PFOSAA and PFOSA levels were determined by Northwest Bioanalytical Laboratory. M570 and M556 levels were determined by the 3M Environmental Laboratory. The overall arithmetic means (and range) and the geometric means and ( 95% confidence interval) of the random sample of chemical employees (n = 126) for the seven fluorochemicals are presented below (in ppm): Chemical Plant Arithmetic Mean (and Range) Geometric Mean (and 95% CI) PFOS PFHS POAA PFOSAA M570 PFOSA M556 1.505 (0.091-10.600) PFOS 0.345 (0.005 -1.880) PFHS 1536 (0.021 -6.760) POAA 0.023 (0.001 -0.269) PFOSAA 0.151 (0.008 -0.992) M570 0062 (0.0005-0612) ~~ PFOSA 0052 (0.001 - 0.406) M56 0941 (0.787 1.126) 0.180 (0145-0223) 0899 (0.722 1.120) 0.008 (0.006-0011) 0.081 (0.067 - 0.098) 00I3 (0.009-0018) 0022 (0018-0029) 001283 EPLO03OmG `The overall arithmetic means (and range) and geometric means ( 95% Page 5 of 85 confidence interval) of the random sampleoffilm plant employees (n = 60) for the seven fluorochemicals are presented below: Arithmetic Mean (and Range) Film Plant Geometric Mean (and 95% CI) PFOS 0.172 (0015-0946) PFOS 0.136 (0.114-0.161) PFHS 0023 (0001-0210) PFHS 0014 (0011-0018) POAA 0071 (0.006 -0.298) POAA 0.049 (0.039 -0.062) PFOSAA 0004 (0001-0038) PFOSAA 0.003 (0.002-0.003) M570 0020 (0.001-0454) M570 0.008 (0.006 -0.011) PFOSA 85% of samples <LLOQ* PFOSA 85% of samples < LLOQ* M556 0008 (0.0001-0307) _ M556 0.003 (0.002 -0.004) LLOQ = lower limit of quantitation for PFOSA ranged from 0.001 - 0.010 ppm. `The above values showed high variability according to the employees' demographics, work history and building locations. Among the random sample (n = 126) of chemical employees, cell operators had the highest serum levels of PFOS. (geometric mean = 1.970 ppm) and PFHS (geometric mean = 0.697 ppm). However, sera from chemical operators and maintenance workers had the highest levels of other fluorochemical analytes (PFOSAA, M570, PFOSA and M556) a characteristic likely due to their work in Buildings 3 and 4N with fluorochemical alcohols, amides and acrylates. For example, chemical operators had a geometric mean levelof0.131 ppm for M570 compared to 0.033 ppm for cell operators, 0.042 for mill operators and 0.079 ppm for waste operators. POAA levels were above the geometric mean of 1.000 ppm for employees with current jobs of cell operators (1.428 ppm), chemical operators (1.887 ppm), maintenance workers (1.095 ppm) , mill operators (1.26 ppm) and waste operators (1.542 ppm). Employees with the job categories of engineer/lab and secretary 001284 EPLO03OMG Page 608f5 had the lowest serum fluorochemical levels. PHS, andto a lesser extent PFOS, were positively associated with years worked in the chemical plant. The remaining fluorochemical analytes were not routinely associated with years worked in the chemical plant by job categories. We did not observe an association between hand-to-mouth usage or hand cleanliness (frequency of washing hands) and serum fluorochemical levels. Like their male counterparts, female chemical operators appeared to have increased PFHS levels with years worked. However, unlike their male counterparts, there was no apparent modest linear association between PFOS and years worked among female chemical operators. Whether this is due to different work practices, exposure `pattems or pharmacokinetics once absorbed, remains to be determined. The sample size itself (n = 10 female chemical operators in random sample), is an important, limiting factor in the interpretation of these data The data also indicate significantly lower serum fluorochemical levels among, employees who have only worked in the film plant Gi.., defined as those employees in the random sample who have worked only in the film plant with no prior work on the D-1 `maker located in the film plant or previous work history in chemical. The D-1 maker uses FX-1801, a methyl FOSE amide). There were significantly lower serum fluorochemical levels among these employees who have only worked in the film plant when compared to those who are current chemical plant employees. Comparing the geometric means for each fluorochemical from the random sampleof chemical operators and those employees. who only have worked in the film plant, we observed the following ratios (in ppm): PFOS (1.481/0.110); PFHS (0.428/0.015); POAA (1.887/0.052); PFOSAA (0.011/0.002); M570 (0.229/0.022); and M556 (0.044/0.003). Except for PFOSAA, these ratios suggest a 10-fold or greater difference between chemical operators and film plant employees who 001285 EPLO030MS Page 7 of85 work several hundred yards away from Building 3. This only film plant employee group had a geometric mean value for PFOS that is approximately 3-4 times higher than the pooled geometric mean (0.029 ppm) from 64 samples obtained from 18 U.S. blood banks. Thus, we suspect that occupational exposure to PFOS does occur within the film plant although at much lower levels than among employees working at the chemical plant. Additionally employees who worked on the D-1 maker have serum PFOS levels approximately 3 times higher than those employees who have never worked on the D-1 `maker nor have worked in the chemical plant i.c., the only film plant employees). `We did not observe an association between hand-to-mouth usage or hand cleanliness (frequency of washing hands) and serum fluorochemical levels. Itis possible an association might have been masked because industrial hygiene had instituted an aggressive educational campaign several months prior to the collection of blood samples in this study; thus current practices may not be indicative of past practices. Because the half-life of PFOS is estimated to be 1000 days or more, such an association may not be discoverable with this study design. A limitation to this study design which must be considered in the interpretation of the data was our inability to more accurately quantify an employee's work history experience. Decatur work history records provide department numbers and job titles but they do not provide information regarding where someone worked (e.g., what building(s) orwith what specific fluorochemicals). Self-reported work history information obtained by questionnaire was highly correlated with Decatur work history record information; nevertheless, the specificity of where someone worked and with what chemicals was not known. Because many operations are in batch mode, the likelihood of determining specificity of historical workload fluorochemical exposure among chemical operators 001286 was not possible. EPLO03OMS Page 8085 The present study's sera fluorochemical levels, observed by job categories and building locations, strongly support the recommendations borne from recently conducted industrial hygiene assessments. These recommendations include specific engineering controls to reduce inhalation exposure, appropriate personal protective equipment to prevent overexposure and appropriate personal hygiene practices among employees to remove skin concentrations. Finally, PFOS and POAA serum levels measured in this study are similar to those: that have been previously reported via past biennial medical surveillance activites. Results of previous epidemiologic studies have not associated the serum PFOSor POAA levels observed in this study population with hepatic, lipid or hormone abnormalities. 001287 INTRODUCTION EPLO0MGmS Page 9.0 85 In the past, employees at the 3M Decatur chemical plant have voluntarily participated in a fluorochemical medical surveillance program. The surveillance program analyzed for total serum organic fluorine levels until the mid-1990's when serum perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (POAA) determination, quantifiable by high performance liquid chromatography mass spectrometry, became incorporated in the biennial medical surveillance examinations. Analysis of the. surveillance data has not shown significant associations between the employees" clinical chemistry and hematology tests and either total serum organic fluorine levels (Roach, 1982; Schuman, 1982)or serum PFOS levels [Olsen et al, 1999]. However, the Voluntary nature of the medical surveillance program may not lend itself to an appropriate characterization of the distribution of fluorochemical serum levels as itis not based on random sampling methods. Therefore, the purpose of this study was to collect data from the necessary distribution by randomly sampling employees in the Decatur chemical plant in order to determine the distribution of employee serum fluorochemical levels according to demographics, current and longest heldjobs, years worked and building locations. In addition, a random sample of the neighboring 3M Decatur film plant employee population, located at the same site, was tested to determine fluorochemical serum levels in order to characterize the differences between the two plant populations. The film plant employees have served as a comparison population in a prior health study (Mandel and Johnson, 1995) due to their (assumed) nonoccupational exposure to fluorochemicals. However, their actual serum fluorochemical levels had not been discerned. Epidemiologic studies at the Decatur plan can be more fully appreciated 001288 EPLO0MDmS if the distributionsof employee serum fluorochemical levels at both the Page 100f85 chemical and film plants are better understood. METHODS Description of Decatur Facility `The 3M Decatur site is located in Decatur, Alabama which started production in the early 1960's. The site consists of two plants, Specialty Film "film plant" and Specialty Materials "chemical plant". Both plants are in the Specialty Materials Manufacturing Division (SMMD). The chemical plant is located several hundred yards directly east of the Film Plant. The main buildings located on the site are Buildings 1,2, 3,5,14,15,17,19, 31, 36, 38, 40, 42, 48, 49, 51, 57, 59 and 61 (see Appendix A). Buildings 14, 15 and 19 are considered film plant buildings. Buildings 1,2, 3, 31, 38, 40, 42,48,49, 51 and 61 are considered chemical plant buildings. Building is the boiler house that controls site utilities such as chilled water, plant steam, plant nitrogen and breathing air. Building 5 is located southwest of the chemical plant. Building 17 serves as the maintenance and stockroom building located just west of Building 5 servicing `mainly the chemical plant. Buildings 36 and 57 are site wastewater treatment buildings located east of the chemical plant. `The major production buildings in Decatur film plant are Buildings 14, 15 and 19. Polyester and non-polyester films are produced in Building 14. Maintenance, locker rooms, and dining facilities are all located in areas of Building 14. Resin used in film production is manufactured in Buildings 15 and 19. The only process in the film plant using fluorochemicals is run on the D-1 film line (called the D-1 maker). The process 001289 EPLO03OMS Page 11 0f85 uses FX-1801 in the production of film used foar limited number of products. Currently, no other processes in the film plant use fluorochemicals in production. The three major products produced in the chemical plant are protective chemicals, performance chemicals, and fluoroelastomers. The three product groups are referred to as focus factories. Fluorochemicals identified in this study are used in all focus factory groups to some extent. Production for all focus factories takes place in Buildings 2, 3,4, 38,40,42, 49, 51 and 61. The chemical plant's main office areas, warchouse and quality control labs are located in Building 1. The chemical plant's dining facility and locker rooms are located in Building 31. Raw materials and intermediates for each product group may flow through many different production buildings before they are packaged for shipping. The flow of protective chemicals follow a path starting at Building 3 to Buildings 2 or 49 to Buildings 3,4,38 or 51. The protective chemicals group is the primary producer of perfluorooctane sulfonyl fluoride (POSF) and perfluorohexane sulfonyl fluoride (PHSF) based chemistry. Octyl mercaptan or hexyl mercaptan is reacted with chlorine and ammonium fluoride to produce octane sulfonyl fluoride (OSF) or hexane sulfonyl fluoride (HSF) in Building 3 and is referredto as the "cell feed". The cell feed is sent to Buildings 2 and 49 where it is reacted in electrochemical cell systems to produce POSF or PHSF. POSE is the major sulfonate based fluorochemical produced at Decatur. PHSF is produced mainlyfor fire suppression liquids. Most of the POSF produced is piped to Building 3 where amides, alcohols, acrylates and other fluorochemical polymers arc produced. These fluorochemical polymers are then used in all production buildings to produce intermediates and finished goods. 001290 EPLO0mOG Page 120185 The performance chemicals are mostly made up of inert liquids and fire suppression liquids. The inert liquids follow a path starting at Buildings 2 or 49 to Buildings 40 or 42. Inert liquids consist of mostly perfluoronated alkanes and do not contain sulfonate or carboxylic acid compounds. Fire suppression liquids are primarily based on sulfonate chemistries starting with POSF and PHSF. Fire suppression products are made in Building 3 and packaged in Buildin4g. Fluorochemicals are used in the productionoffluoroelastomer products. The first part of the fluoroelastomers is called latex, which is produced in Buildings 4, 38 and 51. `The latex is then coagulated, washed and milled in Building4s and 61. POSF based compounds are the primary fluorochemicals of interest used in the majority of fluoroelastomer products. POAA is also used in a limited numberoffluoroelastomer product runs. POAA is used in the production of latex that is eventually coagulated, washed, and milled in Buildings 4and 61. This POAA containing product is run infrequently, only several times per year. POAA is also a by-product within the electrolytic cells and is carried through up to product. It is believed to be a result o f increased oxidation within the cells. POAA was produced in Building 2 and subsequently worked up in Building 3 more than 20 years ago and had not been produced. in Decatur since the time of this study. POAA production is expected to resume in Buildings 2 and 49 in the near future. 001291 Sample Size Determination EPLOO3DMS Page 13 0f85 Three critical factors were considered to decide the sample size for this study. First, it was important that a sample be randomly chosen from the employee populations of both the chemical and film plants. Second, the sample size was driven by the need to provide confidence that the exposure in the film plant is small relative to that of the chemical plant. Third, the sample size had to adequately characterize the exposure levels within the chemical plant workplace. In addition, all employees in the chemical and film plant had to be offered the opportunity to know their fluorochemical levels via blood testing, although they may not be part of the random sample. The random sample size in this study of more than 200 subjects was based on: 1) the lower 95% confidence bound of the hypothesized mean difference between the serum fluorochemical levels of the chemical plant; and 2) to allow for adequate characterization of serum fluorochemical differences by job and building within the chemical plant (see study protocol for details). There was an added degree of uncertainty in estimating sample size because approximately 10 percent of the film plant employees may have had prior work experience in the chemical plant. Also, an unknown number of film plant workers had worked on the D-1 maker where a PFOS-based fluorochemical (FX 1801, a methyl FOSE amide) has been used. `The random sample was chosen by the following methods: a) all full-time current chemical and film plant employees were identified via a current plant roster that listed departments and supervisors; b) using a random number generator algorithm, a sample of `employees was chosen which was proportionate to the number of employees who worked in the various chemical departments, auto and chemical markets group, Decatur EHS&R, Dyneon, and the film plant. We included in the random sample all identified Decatur 001292 EPL0030MS Page 140785 site employees who were assigned to the wastewater treatment plant (Buildings 36 and 57). Altogether, there were 232 employees randomly chosen to participate in the study (Table 1).A total of 186 (80%) participated and 46 (20%) refused. The film plant random sample had the lowest participation rate (71%). In addition to the 186 random sample participants, there were77 employees from the chemical (n = 61) and film (n = 16) plants who requested their serum be tested for fluorochemical levels. Hereafter, these individuals will be called the "volunteers." Employee Study Participation Study participation required the following: 1) a signed consent form by the employee; 2) a written response to a brief questionnaire (Appendix B) that inquired about current and past work history along with the frequency of hand washing and use of gum, chew (tobacco) and cigarette habits of the employee while at work; and 3) a venipuncture with the collection of two vials of blood (approximately 20 ce) for the determination of the seven fluorochemicals. The study protocol was approved by the 3M Institutional Review Board (IRB). Each randomly chosen employee (film and chemical) received a letter of invitation to participate that was jointly signed by the plant manager (Mr. Jim King) and the 3M Medical Department director (Dr. Larry Zobel). There was plant-wide communication which described the purpose of this study and encouraged employee participation. All study participants, who were either randomly chosen or who volunteered, were informed of their own individual results by a letter sent to them from the 3M Medical Department in July, 1999. Aggregate results of the study were also communicated at that time to the employees. 001293 EPL0030M6 Page 15 of 85 Fluorochemical Analyses All blood was collected in the months of October and November, 1998 at the Decatur plant by MedAccess (an occupational health clinic located in Decatur, Alabama) under the direction of Cathy Simpson, RN who centrifuged the bloodto obtain the serum and then shipped the samples to the 3M Medical Department (St. Paul, MN). Split samples were catalogued by Diane Madsen and Jean Burris and then senttoeither Northwest Bioanalytical (Dr. David Vollmer) for determination of perfluorooctane sulfonate (PFOS), perfluorooctane sulfonate amide (PFOSA), perfluorohexane sulfonate (PFHS), perfluorooctanoic acid (POAA) and N-ethyl perfluorooctanesulfonamido acetate (PFOSAA)orto 3M Environmental Laboratory (Dr. Kris Hansen) for determination of N-methyl perfluorooctanesulfonamido acetate (M570) and `perfluorooctanesulfonamido acetate (M556). In both laboratories, sera samples were extracted using an ion-pairing extraction procedure. The extracts were quantitatively analyzed for PFOS, PFHS, POAA, PFOSAA, PFOSA, M570 and M556 using high-pressure liquid chromatography/electrospray tandem mass spectrometry (HPLC/ESMSMS) and evaluated versus an extracted curve, There were minor differences between the analytical methods used at Northwest Bioanalytical and 3M Environmental Laboratory. Most notably, Northwest Bioanalytical evaluated analyte levels versus a curve extracted from human sera. Endogenous levels of certain fluorochemicals were determined in the standard matrix and additional fluroochemical was spiked into the matrix. The total `amount of each specific fluorochemical (endogenous + spiked) was used to construct an extracted standard curve. For the analysis conducted at the 3M Environmental 001294 EPL00m0M6 Page 16 of 85 Laboratory, the difficulties presented by the endogenous levels of fluorochemical in samples of "blank" test matrix were circumvented by utilizing rabbit sera as a surrogate matrix. Previous research had shown that rabbit sera contains the lowest level of endogenous fluorochemicals when compared to sera from bovine, rat, monkey and human. `Asa quality control check, the 3M Environmental Laboratory screened PFOS levels in approximately 10% of the sera analyzed at Northwest Bioanalytical. While most of the results agreed to within 25%, 14 of the 40 samples checked showed lower (>% 25%) values when analyzed at 3M. It is expected that these discrepancies are due to differences in curve slope and intercepts arising from the analytical differences described above. Given that Northwest Bioanalytical satisfactorily completed a method validation for PFOS using human sera and given that most values were in close agreement with those obtained by the 3M Environmental Laboratory using a rabbit sera curve, data from both laboratories were considered accurate to within the parameters defined by their methods. Details of both laboratories' methods and final reports are reported elsewhere (Vollmer, 1999; Hansen, 1999]. Data Analysis Each employee's questionnaire data and computerized work history records were reviewed to determine whether the employee was: a) a current chemical employee (regardless of any work experience in the film plant); b) a film plant employee with no history in chemical;or ) a film plant employee with prior history in chemical. Employees who were considered Decatur `site' employees (e.g., safety, industrial 001295 EPLO0mOS Page 170785 hygiene) and who stated they currently worked in one or more chemical buildings were considered to be chemical employees in the data analyses. Employees were asked to provide their current and longest-heldjob. A review of these job titles by an industrial hygienist (PWL), epidemiologists (GWO, JMB) and occupational health nurse (CAS) categorized the entries into eight job classifications for the chemical plant: cell operators, chemical operators, engineers/laboratory, maintenance, mill operators, secretaries, supervisors/management and waste operators. Film plant current jobs (and longest held jobs) were categorized into fourjob classifications: engineers/laboratory, film processors, maintenance and administrative. These classifications were done prior to any data analyses. The individual's usual job assignment when he/she worked overtime was not analyzed as most persons reported this was the same as their current (or longest held)job. Employees were asked on the study questionnaire to indicate the number of years they have worked in chemical. This information correlated with a review of records from the epidemiology unit's Decatur work history database for those employees with 7000 level department codes; thus these self-reported data were used to assess years worked in chemical. On the other hand, years worked in film were calculated from the epidemiology unit's Decatur work history database because this information was not requested on the study questionnaire. Chemical employees who had worked previously in the film plant were identified and classified as to their time of service in the film plant (< 1980, 1980-1989 and 1990-1998). Age was calculated from the employee's date of birth from the epidemiology unit's Decatur work history database. Body mass index (kg/m?) was calculated based on the information provided by the employee on the questionnaire. An index of hand-tomouth contact was calculated based on whether the person smoked cigarettes, chewed 001296 EPLO03OMG Page 180f 85 tobacco or chewed gum. An index of hand washing was based on whether or not the employee said they always washed their hands before cating while at work. Through the use of SAS and JMP and employing standard statistical techniques (student's t test, chi square, ANOVA, single and multivariable regression using linear and nonlinear analyses), data analyses concentrated on the following issues: 1) compare: responders and nonresponders in the random sample bytheirdemographic characteristics (e.g, age, gender, years worked); 2) compare mean serum fluorochemical levels within the chemical plant by 2) employee demographics, b) self-reported work history data based from the study questionnaire including current job, longest-heldjob, years worked in chemical and in which chemical buildings; ) work history information supplemented with data from the 3M epidemiology unit's computerized comprehensive work history record database for the Decatur site, and d) personal habits (also identified on the study questionnaire) that were hypothesized to increase the likelihood of oral ingestion of fluorochemicals (e.g., hand washing, cigarette smoking, chewing tobacco and chewing gum); and 3) likewise, compare mean serum fluorochemical levels within the film plant by similar factors. To prevent misclassification of potential workplace exposure experience to fluorochemicals within the film plant, we analyzed samples from film plant employees according to those who have and have never worked in the chemical plant as well as those who were identified as having worked on the D-1 maker located in the film plant. Film plant employees who had never worked on the D-1 maker nor ever worked in chemical are hereafter referred to as "only film plant employees." Because the serum distributions for PFOS, PHS, POAA, PFOSAA, MS70, PFOSA and M556 appeared log normallydistributed (a skewed distribution), natural log transformations of the fluorochemicals were performed to calculate geometric means 001297 am ge100185 (TM "9) and statistical calculations regarding central tendency were primarily based on the geometric mean. The random variable X is said to have a log normal distribution if log X is normally distributed, that is, if X is of the form " where Y is normal (i.c., the normal bell shaped curve). The pertinent properties oaf log normal distribution can then be derived from properties of the normal distribution. The mean and variance are of the `normally distributed Y, that is, of log X. The log normal distribution finds applications in a wide variety of fields including exposure assessments in nature (whether of humans, `mammals, etc). Provided in Appendices C and D are the histograms of the seven fluorochemicals as measured for employees in the chemical and film plants, respectively, using statistics derived from the normal distribution along with the natural log transformation of the distribution. The Shapiro-Wilk W test suggests the necessity of the log transformation. Measuresofcentral tendency routinely presented throughout this report will include the arithmetic mean and range, and the geometric mean and associated 95% confidence interval. Comparisons of geometric means were conducted using the student'st test with statistical significance considered atp < 05. All fluorochemical measurements were reported in parts per million (ppm) to the third decimal point. For statistical purposes, serum fluorochemical values that were less than the lower limit of quantitation (LLOQ) were assumed the midpoint between zero and the LLOQ. Of the total number (n = 186) of employees considered to be currently working in chemical who participated in the study (126 from the random sample and 60 volunteers), the following numbers (in parentheses with percentage) had reported LLOQ's by the measured fluorochemical: PFOS (1, 0.5%); PHS (1, 0.5%); POAA (0, 0%); PFOSAA (49, 26%); MST0 (0, 0%); PFOSA (36, 19%); and M556 (8, 4%).Ofthe 001298 EPLO0MOG Page 200f 85 total number (n = 76)of employees considered to be current film plant (60 in the random sample and 16 volunteers), the following numbers (in parentheses) had reported LLOQ's by the measured fluorochemical: PFOS (1, 1%); PFHS (2, 2%): POAA (0, 0%); PFOSAA (29, 38%); M570 (0, 0%); PFOSA (65, 86%) and M556 (32, 42%). We chose not to analyze PFOSA among the film plant employees because 85% of them had serum PFOSA measured at less than LLOQ which resulted in minimum variability for statistical considerations. The LLOQ for PFOSA ranged, between analyses, from 0.001 10 0.010 ppm. Analyses focused on the random sample but aggregate data analyses were also `conducted for all participants (random sample and volunteers) stratified by the two plants. RESULTS Comparison of random sample responders and nonresponders Responders (n = 186) and nonresponders (n = 46) from the random sample were. compared by age, gender and years worked and found to be alike. Among the chemical random sample, the average age was 42 years compared 0 43 for nonresponders. Responders and nonresponders have worked, on average, 16 years. There wasa simila5r 0 1 ratio of male to female employees for the responders and nonresponders among chemical employees. Film plant employees who responded were, on average, 46 years of age, had worked 19 years and the ratio of male to female was 5 to 1. Nonresponders were 48 years of age, had worked 25 years and had a 7 to 1 male to female ratio. Thus, nonresponders in the film plant random sample were slightly older, worked longer and a greater percentage were males. 001299 EPL00m0MG Page 21 of 85 Overall Findings `The arithmetic mean (and range) of the random sample as well as the geometric: mean and ( 95% confidence interval) of chemical employees (n = 126) for the seven fluorochemicals are presented below (in ppm): Chemical Plant Arithmetic Mean (and Range) Geometric Mean (and 95% CI) PFOS PPOFAHSA PFOSAA M570 PFOSA M556 1505 (0.091-10.600) PFOS 0345 (0.005 -1.880) PFHS 1536 (0.021 -6.760) POAA 0023 (0.001-0269) PFOSAA 0.151 (0.008 - 0.992) M570 0062 (00005-0612) ~ PFOSA 0052 (0.001 - 0.406 M56 0941 (0.787 - 1.126) 0.180 (0.145 -0.223) 0899 (0.722- 1.122) 0.008 (0.006-0011) 0081 (0.067 -0.098) 0013 0022 ((00..001089--00.001289)) `The arithmetic mean (and range) of the random sample as well as the geometric mean and ( 95% confidence interval)of the film plant employees (n = 60) for the six fluorochemicals are presented below: Film Plan Arithmetic Mean (and Range) Geometric Mean (and 95% CI) PFOS 0.172 (0.015-0.946) PFOS 0.136 (0.114-0.161) PFHS 0023 (0001-0210) PFHS 0014 (0.011-0.018) POAA 0.071 (0.006 -0.298) POAA 0.049 (0.039 -0.062) PFOSAA 0.004 (0.001 -0.038) PFOSAA 0.003 (0.002 -0.003) M570 0020 (0.001 -0454) M570 0.008 (0.006-0.011) PFOSA 85% of samples <LLOQ* PFOSA 85% of samples < LLOQ* M556 0008 (0.0001 -0307) _MsS6 0.003 (0.002 -0.004) LLOQ = lower limit of quantitation for PFOSA ranged from 0.001 - 0.010 ppm. Because the above values may be highly variable by employees' demographics, work history and personal habits, subsequent analyses will focus on cach plant separately 601300 EPLO03OMG Tables 1 - 21 provide the results from the chemical plant. Tables 22 - 20 Page 220f provide the 85 results from the film plant Chemical Plant Provided in tables 2 and 3 are the demographic characteristics by the number of chemical employees (and percent) from the random sample (n = 126), volunteers (n = 60) and all chemical participants (both random sample and volunteer, n = 186). The distribution ofdemographic characteristics between the random sample and volunteers were comparable although the random sample had a higher percentageof chemical operators (37%) than did the volunteers (28%). `The mean, median, range and geometric mean of the random sample, volunteers and all chemical participants, is provided in Tabl4e for the seven fluorochemicals. The range of PFOS was from 0.091 - 10.600 ppm. Although the geometric means were consistently higher in the random sample than volunteers, only with PFOSA did the `geometric mean differ significantly between the random sample (0.013 ppm) and the volunteers (0.006 ppm). It should also be noted that among the random sample, five employees had serum PFOS levels > $ ppm compared to none among the volunteers. Because the demographic characteristics and geometric means did not substantially differ between the random sample and volunteers, subsequent tables wil report on cither the random sample and/or all chemical participants. The volunteers will not be presented separately. Presented in Table S are the demographic characteristics of the random sample of chemical employees by current job category (cell operator, chemical operator, engineer/lab, maintenance, mill operator, secretary, supervisor/management and waste: 001301 EPL00m0M6 Page 23 of 85 operator). Supervisors/imanagement (mgmt) and waste operators were the oldest with mill operators the youngest. Mill operators have worked considerably less years, on average, than all otherjob categories. This is to be expected since mill operator is an entry level position for new employees. The number (and proportioonf) female: `employees were similar between the chemical operators and the engineer/lab group. Provided in table 6 is the mean, median and geometric mean for each of the seven fluorochemical levels by gender, hand-to-mouth contact, wash hands and whether the individual had worked only in the chemical plant. Geometric mean levels for males were significantly higher than females for PFOS, PFHS, POAA and MS70. We did not observe, as hypothesized, that hand-to-mouth contact (via use of cigarettes, chewing tobaccoor chewing gum) and less frequent hand washing resulted in higher fluorochemical serum levels. Also, having worked only in chemical did not result in higher serum fluorochemical levels. We did observe that the further back in time that chemical employees worked in the film plant, the larger their geometric mean values were, as measured in this study. For example, the geometric mean values for chemical employees who last worked in the film plant prior to 1980, between 1980-1989, 19901998 and never worked in the film plant were 1.656 ppm, 1.551 ppm, 0.786 ppm and 0.700 ppm, respectively. Of course, this is also a reflection of the number of years worked in the chemical plant (to be presented later in this section). That s, the employees who worked in the film plant prior to 1980 had subsequently the longest continuous work history in chemical since 1980. Fluorochemical levels by current job category are presented in Table 7. Several observations were noteworthy. First, the distributionofhigh-to-low geometric mean values varies by current job categories. Cell operators have the highest geometric mean 001302 EPL00m0M6 level of PFOS. The next group are the chemical operators, maintenance and Page waste 24 of 85 operators. Supervisor/memt is next, followed by the group consisting of mill operators, engincerflab and secretary. For PFHS, cell operators have the highest geometric mean level. The next highest group appears to be chemical operators, waste operators, supervisor/mgmt and maintenance. For POAA, chemical operators appear to have the highest levels followed by the group consistingofcell operators, maintenance, mill operators and waste operators. Chemical operators and maintenance have significantly higher levels of M570 than all other currentjob categories. Chemical operators, maintenance and mill operators have the highest geometric mean values for PEOSAA. PFOSA and M556 values were significantly higher for chemical operators than for most otherjob categories. Fluorochemical ratios (PFOS/PFHS, PFOS/POAA, PFOS/(PFOSSA+MST0+PFOSA+MSS6), MST0/MSS6, PROSAA/MSS6 and PFOSA/MSS6) are presented by current job category in Table 8. The cell operators had the lowest PFOS/PFHS ratio and the mill operators had the lowest PFOS/POAA ratio. `The largest PFOS/metabolite ratio was for the cell operators. Tables 9-11 are identical to Tables 7-9, respectively, except that the employees" longestjob is analyzed instead of the current job category. Cell operators are not included as there was only one cell operator who stated this was his longest job held. The highest PFOS, PFHS and POAA levels were observed among chemical operators. Maintenance and chemical operators had higher M570 and PFOSAA levels. Overall, results did not vary substantially between current job and longest heldjob. Table 12 is restricted to only those chemical employees who stated on the questionnaire that they currently work in just one location (building). Because building 0601303 EPLO0MOmS Tocation is synonymous with job category for cell operators, Buildings 2/49 hadPatghee25 0f 85 highest PFOS and PFHS levels. Building 3 and Building 4N represented the areas with the highest POAA levels although only one building, Building 1, had substantially lower POAA levels when compared to the other locations. M570, PFOSAA and MSS6 levels were highest in Buildin3g. Buildings 3 and 4MX (MX = mixer/extruder area) appeared to have comparable levels of PFOSA. Among the 5 employees who only worked in Building 4N, there was a wide range of PFOSA levels. Because employees may currently work in only one building but have had a past history of working in several buildings, we further restricted the analyses to only those employees who said they have only worked in one building throughout their employment. This restricted the number of subjects to just 21 individuals (17% of the random sample) with representation in these Buildings: 1,3 and 4MX. Table 13 shows that PFOS levels were more than 5 times higher in the sera of Building 3 workers than in the sera of Building 1 or Building 4MX workers. PFHS levels were almost 10 fold higher. POAA levels were twice as high in sera of Building 3 workers compared to Building 4MX workers and more than 15 times higher than Building 1 workers. MS70 and M5S6 levels were times higher in Building 3 workers than Buildings 1 or 4MX. PFOSAA and PFOSA levels were comparable between Building 3 and Building 4MX workers and lowest in Building 1. Tables 14 through 21 provide similar data analyses as the previous tables but now represent the 187 total (random sample and volunteers) chemical participants. There were no substantial differences between the analyses of the random sample and of all chemical participants. For example, among all chemical participants, mill operators were the youngest employees (Tables 14, 17); most female employees were either in the 001304 EPLO03OMG current and longest job category of chemical operators or engineer/lab Page (excluding 26 of 85 secretary) (Tables 15, 18); cell operators had the highest PFOS and PFHS serum levels and engineer/lab, secretary and mill operators had the lowest PFOS and PFHS serum levels (Tables 16, 19); and chemical operators and maintenance workers had the highest levels of M570 and tended to also have the highest serum levels of PFOSAA, PFOSA and M56. Fluorochemical levels stratified by where employees only currently work. (Table 20), or have only ever worked (Table 21), were also comparable with the results. from the random sample. All chemical participants who have only worked in Building 1 had lower fluorochemical levels than Building 3 workers for all seven fluorochemicals (Table 21). Building | workers had lower PFOS, POAA, PFOSAA and PFOSA levels than Building 4MX employees. PFHS, M556 and MS70 levels were similar in Building 1 workers and Building 4MX workers. A series of multivariable analyses (data not shown) examining each fluorochemical by several independent variables (c.g. age, body mass index, gender, current job, longest-held job, whether employed only in the chemical plant, years worked in the chemical plant) suggested there may be up to three important explanatory variables. These were current (or longest) job, years worked within the chemical plant and gender. To better visualize the influence of years worked within chemical on serum fluorochemical levels, we stratified the analyses by current job categories. In other words, the dependent variable (i.c., each specific fluorochemical) was regressed on years worked in chemical for each separate job category. These linear regression analyses employed the untransformed as well as transformed (natural log) dependent variable. Analyses were conducted for the random sample (n = 126) as well as for all chemical 001305 EPLO03OmS participants (n = 187). Presented in Appendix E are the analyses for cach Page 27 0f 85 fluorochemical for the random sample (n = 126) and then separately for chemical operators, engineer/lab, maintenance, mill operators and supervisors/mgmt. Cell operators and secretaries are not presented becauseof their insufficient population. From the scatterplots and models presented in Appendix E, the following were. observed. (Note: in Appendices fluorochemicals are presented in the following order PFOS, PFHS, POAA, PFOSAA, M570, PFOSA and M56. For the scatterplots, upper and lower 95% confidence curves are provided of the fitted line. First, for the entire: random sample, only the PFHS model fit the data well with 22 percent of the variation of PFHS explained by an increase in years worked in chemical. PFOS levels increased modestly with years worked in chemical although the variance explained remained small (*=.10). Although intercepts may have been significant for other fluorochemical models for the entire random sample, the variance explained was consistently quite small (i. less than 3 percent); thus such models have minimum prediction. Among chemical operators the most significant observation was the findingof a linear increase of PFHS levels with increasing years worked in chemical. Thirty-four percent of the variation in PFHS was explained. There were weaker positive linear associations between POAA or PFOS and years worked in chemical. On the other hand, there appeared to be a suggestion that the highest levels of the fluorochemical analytes (PFOSAA, M570, PFOSA and M556) were most often observed among chemical operators with just one or two years of experience. Among the engineerflab group, there was a weak association between scrum PFOS levels and years worked in chemical. The strongest association observed among maintenance workers was the linear increase of PFHS levels with years worked in chemical. Like the chemical operators,a significant amount of variation was 001306 EPLO30mG explained (26 percent) although the data were sparse. Among the supervisor/Pmaggmet28 of 85 group, PFOS, PFHS and POAA increased with years worked in chemical. Approximately 15 percent of the variation was explained in each model. Model fit was poor for the mill operators because all but two had worked for 5 years or less; thus only scatterplots are presented (not regression models). The natural log transformations are presented in AppendixF for all chemical `employees (n = 126) in the random sample as well as for the two current job categories with the most numbers (chemical operators and engineer/lab). For the entire random sample, a weak association (r" = 08) is observed for PFOS and years worked in chemical and a stronger association (= .23) for PFHS. For chemical operators the strongest association (= 34) is with PFHS and years worked in chemical. Although the latter association was not observed among the engineer/lab category with the nontransformed variable (see Appendix E), the natural log transformation of PFHS was significantly associated (r=* .19) with years worked in chemical (see Appendix F). Presented in Appendix G are similar scatterplots and regression models for all chemical participants by currentjob category. There remained a positive association between PFHS or PFOS serum levels and years worked in chemical, with the stronger of these two associations for PHS. Because of more subjects, scatterplots are also now shown for cell operators. These plots suggest, again, an increase in PFOS, PFHS and now also POAA levels among current cell operators with years worked in chemical, Among chemical operators the strongest association remained with PFHS, with weaker linear associations observed for PFOS and POAA with years worked in chemical. Among the engincer/lab group, there remained apositive linear association between either PHSorPFOS with years worked in chemical. There were positive linear 001307 EPL00a0mS associations for PFOS, PFHS and POAA with years worked in chemical Page 29.0785 among both the maintenance and supervisor/memt groups. Too few mill operators with 5 or more work years in chemical were sampled to conduct a meaningful analysis. The scatterplot data do show a wide range of serum POAA levels among mill operators with just one year of work experience in chemical. `The scatterplots in Appendix H represent the log transformations for all chemical participants and the two most numerous job categories: chemical operators and engineer/lab. Again, the scatterplots suggest a consistently strong positive association between serum PFHS levels and years worked in chemical and a lesser association with PFOS and years worked in chemical. Presented earlier in Table 6 was the observation that serum fluorochemical levels were lower among female workers. Whether this was due to a smaller proportion of female workers in job categories where exposure would be the highest, younger female workers and/or female employees with less work experience in chemical remained to be resolved. To address this issue we focused on those two job categories that had the most female subjects within the random sample as well as all chemical participants: chemical `operators and the engineer/lab group. Presented in Tables 22 and 23, by gender, are the demographic characteristics and serum fluorochemical levels for the random sample of chemical operators and the engineer/lab group. Female employees had significantly lower geometric mean serum levels of POS, PFHS and POAA. Multivariable analyses of chemical operators ofeach fluorochemical level regressed on gender, years worked in chemical and with and without age are presented in Appendix I for the random sample. For purposes of brevity, only the transformed (natural log) dependent models are presented. Gender appeared to be the best predictor of PFOS level (ic., lower levels 001308 EPL00m0G among female chemical operators) with years worked in chemical not Page significantly 300f 85 associated with PFOS. Gender was also significantly associated with POAA levels (lower POAA levels among female workers) adjusting for years worked in chemical and age. Both gender and years worked in chemical appeared to be important predictors of PFHS levels among chemical operators. Among the random sampleof engincer/lab `workers, gender was the most important predictor of PFOS, PHS, POAA and PFOSAA levels after adjusting for years worked in chemical and age (Appendix J). Data for chemical operators and the engineer/lab group from the all chemical participants showed comparable results (Appendices K and L). To further clarify this issue, regression analyses were stratified by gender as well as byjob category. With male chemical operators as well as with the male engincer/lab `group, there was a consistent association of increasing levels of PFOS and PFHS (and POAA for chemical operators only) with increasing years worked, at least for the first several years of work. Scatterplots are found in Appendix M. More questionable is whether such an association remains linear or is polynomial (quadratic) over time. Among female chemical operators the only association observed was for PHS and years worked. Scaterplots are found in Appendix N. Neither PFOSor POAA levels appeared to increase with years worked in chemical among female chemical operators. `The data for the female engineer/lab group are difficult o interpret since 6 of the 9 individuals had less than years of work in chemical. Use of an interaction term (gender x years worked in chemical) in multivariable models was not an important predictor of fluorochemical levels 001309 Film Plant EPLO03DMG Page 31 0f 85 Altogether there were 60 current employees who responded to the film plant random sampling. A total of 36 employees had worked only in the film plant (i.c., `only in the film plant' refers to film plant workers with no known experience on the D-1 maker or have had no previous work experience in the chemical plant), 6 film plant employees were known to have worked on the D-1 maker and 18 employees had worked, at some time previously, in the chemical plant but were not on the D-1 maker (Table 24). For all film participants (n = 76, random sample and volunteers), a totalof 49 had worked only in the film plant, 7 were known to have worked on the D-1 maker and 20 had worked, at some time previously, in the chemical plant. Among the 60 employees of the random sample, there were no substantial demographic differences (Table 25) between the only film, the D-1 maker and prior chemical history groups. However, there were significant differences in serum fluorochemical levels among these three groupsoffilm plant workers. Those employees who have only worked in the film plant (but not on D-1 makeror previous chemical plant history) had significantly lower mean PFOS levels (Table 26). The geometric mean of PFOS for only film plant workers was 0.110 ppm (95% CI 0.094-0.129) compared to 0.289 ppm (95% C1 0.159-0.527) for employees known to have worked on the D-1 maker and the geometric mean was 0.178 ppm (0.137-0.233) for film plant employees with prior history in chemical. A similar significant association, albeit at a lower ppm level, was observed for POAA. The only film plant employees had significantly lower 'PFHS levels when compared to film plant workers with a previous history in chemical; their PFHS levels were nonsignificantly lower than those who worked on the D-1 maker. `There were no significant differences in sera levels of the remaining fluorochemical 001310 EPLO030MG levels among the three groups of film employees. Interestingly. all film plant wPoargkee3r2s0f 85 with a previous history of having worked in the chemical plant had MSS6 values that were below the LLOQ. We do note that the D-I maker group had comparable levels of MS70 to the only film or film with previous history in chemical groups (see Table 26). `We had hypothesized the D-1 maker group may have had higher levels because of their use of methyl FOSE amide which may metabolize to the analyte MS70. Provided in Table 27 are ratios of fluorochemicals. The median ratios were comparablefor these groups of film plant workers in the random sample. Restricting the analyses to film employees with no D-1 maker or chemical plant experience, there were no significant differences by age for the four current job categories analyzed: engineer/lab, film processor, maintenance and administrative (Table 28). Although their serum levels were substantially below their counterparts in chemical, maintenance employees working in the film plant had significantly higher PFOS, POAA and MS70 levels than the engineer/lab group within the film plant (Table 29). Engineer/lab, film processors and administrative workers had comparable fluorochemical serum levels. Median fluorochemical ratios were comparable among. these job categories of the random sample of film plant workers (Table 30). Similar findings were observed when all film plant participants were analyzed for demographics and serum fluorochemical levels (Tables 31-33). Located in Appendix O are scatterplots of the only film group for each fluorochemical regressed on years worked in film. Because maintenance workers had higher levels, on average, than the other three job groups among the only film employees, they are numbered on the graphs. From these analyses there is some suggestion that PFOS and POAA levels may increase within the first few years of working at the Decatur 001311 EPL0030mS film plant and then subsequently plateau. However, unlike chemical workers, Ptahgeere33i0s7n8o5 linear (or quadratic) association observed for PHS. The remaining fluorochemicals showed no association with years worked in film. DISCUSSION The goal of this research effort was to quantify, based on random sampling, the relationship of employee serum levels of seven fluorochemicals at the Decatur chemical and film plants. In that regard, the data collected and analyzed present a convincing picture of significantly lower serum fluorochemical levels among employees who have only worked in the film plant when compared to those who are current chemical plant employees. For example, comparing the geometric means for each fluorochemical between chemical operators and those employees who only have worked in film, we observed the following ratios: PFOS (1.481/0.110); PFHS (0.428/0.015); POAA (1.887/0.052); PFOSAA (0.011/0.002); M570 (0.229/0.022); and M556 (0.044/0.003). `These ratios, except for PFOSAA, suggest a 10-fold or greater difference between chemical operators and film plant employees who work several hundred yards away from Buildin3g. These only film plant workers appeatro have a geometric mean value for PFOS that is approximately 3-4 times higher than the pooled geometric mean (0.029 ppm) from 64 samples obtained from 18 U.S. blood banks; thus, we suspect that `occupational exposure to PFOS occurs within the film plant although at much lower levels than among employees working at the chemical plant. Among filmplant employees we also established the fact that workers on the D-1 maker have serum PFOS levels approximately 3 times higher than those who have never 001312 EPLO0MGmG Page 34 of 85 worked on the D-1 maker nor have worked in the chemical plant. Unexplained is the. POAA levels of these workers on the D-1 maker as well as the levels observed among other film plant employees. We confirmed several hypotheses for the chemical plant employees. First, cell `operators have the highest serum levels of PFOS and PHS although their serum levels for other fluorochemical analytes were similar to other chemical employees who were involved with the chemical reactors (i.c., chemical operators and maintenance workers). Second, chemical operators and maintenance workers had comparable serum fluorochemical levels. Besides their higher levels of PFOS and PFHS, they both had significantly higher levels of M570 (the methyl FOSE alcohol metabolite) and to a lesser degree to POSAA which is the ethyl FOSE alcohol metabolite (as well as an FC product itself, FC-129). Chemical operators, but not maintenance workers, had higher levels of PFOSA. Both chemical operators and maintenance workers had moderately higher levels of M556 than the other job categories. These data suggest that, beyond general plantbased environmental exposure to POSF and PHSF (which we assume is primarily through inhalation and conversion to PFOS and PHS, respectively), the chemical operators and maintenance workers have higher serum levels as a result of their occupational exposure to the fluorochemical products. These occupational exposures `may be from the FC alcohols, FC amides, and FC acrylates. Because these fluorochemicals have much lower vapor pressure than POSF and PHSF, these data may indicate that the exposure to these chemical products within the chemical plant is relatively limited to within Building 3 and Building 4N. Third, waste operators were comparable to chemical operators for serum levels of POS and PFHS bu, like the cell operators, did not have higher levels of the fluorochemical analytes. Fourth, mill 0601313 EPL00a0m6 operators were generally much younger employees and their highest Page 35.0185 fluorochemical serum level was to POAA. Yet, the mill operators' POAA levels were lower than those of cell operators, chemical operators and maintenance workers. This suggests there is plant-based exposure of POAA well beyond the Buildin4g area which may be due to the fact that POAA is a by-product of the electrolytic cell production. Finally, the data support the hypothesis that those individuals (.g., engineers and secretaries) who are. much less likely to have routine occupational exposure within the chemical plant, do, indeed have lower serum fluorochemical levels. Employees who have only worked in Building 1 which is immediately across the walkway from Building 3, have serum fluorochemical levels that range between 7 (PFOS, PFHS) and 15 times (PFOSAA) lower than employees who have only worked in Building 3. Our analyses of fluorochemical levels in serum from randomly selected employees strengthen the recommendations that were recently made in a Decatur industrial hygiene assessment analysis [Logan, 1998]. There is a strong correlation between the higher employee serum levels in the present study and air, surface and personal monitoring measurements which occurred during the industrial hygiene assessment. In the industrial hygiene assessment, Building 3 had the highest average airbomne total fluorochemical levels with each value derived from the total mass of detected target analytes in each sample (POSF, PHSF, FC amides, FC alcohols, FC acrylates) (see below): BldgNo. 1 3 4 Outside air *mg/m Results of Fluorochemical Tube Air Samples No. Samples Average Low" 19 00145 0.000 66 1.6884 0.0070 10 0.1269 0.0047 3 0.0861 0.580 High 0.0601 38.0583 05216 0.1247 0601314 EPLO03OMG Surface wipe sampling was also conducted throughout the chemical plant Page 36.0f (Buildings 1, 85 2, 3.4,17,38,49, 51 and 57). Sample results indicated that fluorochemicals were found in nearly all samples with large variations in concentration. Building 3 had the highest surface fluorochemical contamination with the average surface concentration greater than 100 ug/100cm'. Also, methyl FOSE alcohol was the largest contributor of fluorochemicals found throughout surface wipes in Building 3. Hand-wipe samplings indicated that employees who had washed their hands had very low levels of fluorochemicals detected. Methyl FOSE alcohol and POAA were the compounds found `most often on employees' hands. Thus, the present study's sera fluorochemical levels, observed byjob categories and building locations, strongly support the recommendations `bome from industrial hygiene assessments. These recommendations include specific engineering controls to reduce inhalation exposure, appropriate personal protective equipment to prevent overexposure and appropriate personal hygiene practices among. employees to remove skin concentrations. For the first time we have shown a relationship between serum PFHS levels and the number of years worked in chemical. This finding was observed across various currentjob categories within chemical which suggests PHSF, duc to its high vapor pressure, is likely present throughout the chemical plant premises. The pharmacokinetics of PFHS are unknown, although due to the shorter chain length, we suspect the biological half-life may be less than PFOS, We observed only a modest association between years worked in the chemical plant and serum PFOS, and to a lesser extent POAA, levels. These associations appear to be more evident among employees within their first five years as demonstrated by significant quadratic associations found with both male chemical operators and 001315 engineers/laboratory personnel EPL00m0MG Page 37 of 85 Like their male counterparts, female chemical operators appear to have increased PFHS levels with years worked. However, unlike their male counterparts, there was no apparent linear association between PFOS and years worked. Whether this is due to different work practices, exposure patterns or pharmacokinetics once absorbed, remains 0 be determined. Gender-related differences in the toxicokinetics of POAA have been reported for rats although the mechanismof excretion may be species dependent since these gender differences were not observed in mice, rabbits or dogs [Griffith and Long, 1980; Hanhijarvi and Ylinen, 1988]. The half-life of POAA was estimated to be 7 times higher (7 days) in male rats than female rats. Alimitation to this study design which must be considered in the interpretation of the data was our inability to more accurately quantify an employee's work history experience. Decatur work history records provide department numbers and job titles but they do not provide information regarding where someone worked (e.g., what building(s) or with what specific fluorochemicals). Self-reported work history information obtained by questionnaire was highly correlated with Decatur work history record information; nevertheless, the specificity of where someone worked and with what chemicals was not known. Because many operations are in batch mode, the likelihood of determining specificity of workload fluorochemical exposure among chemical operators is not possible. Furthermore, such records do not exist back in time. Nevertheless, with use of the employees current (or longest) job along with additional surrogate variable exposures. (years worked in chemical, building number) we were able to compare and contrast fluorochemical levels. The least predictive of these three variables (job type, building and years worked) was years worked with the exception of PFHS where a strong linear 001316 association existed across job categories for PFHS with years worked. EPLO03OMG Page 38 of85 We did not observe an association between hand-to-mouth usage or hand cleanliness (frequency of washing hands) and serum fluorochemical levels. It is possible an association might have been masked because industrial hygiene had instituted an aggressive educational campaign several months prior to the collection of blood samples in this study; thus, current practices may not be indicative of past practices. Because the. half-life of PFOS is estimated to be 1000 days or more, such an association may not be discoverable with this study design. `The serum levels observed in this study for PFOS and POAA are not different than those that have been previously reported for this study and other 3M occupational populations [Olsen et al., 19983, 1998b, 1999]. Olsen et al. [1999] have not associated hepatic or lipid abnormalities with PFOS levels in the Decatur and Antwerp plant populations that underwent voluntary medical surveillance in 1995 and 1997. Hepatic lipid or hormone levels have not been associated with serum POAA levels among 3M Cottage Grove male workers who have experienced higher serum fluorochemical levels than those determined in the present study for these Decatur employees [Gilliland and Mandel 1996; Olsen et al. 19983; 1998b]. In summary, the objective of this proposed research study was to characterize , via random sampling, the distribution of employee serum levels of PFOS, PHS, POAA, PFOSAA, M570, PFOSA and M556 at the 3M Decatur chemical and film plants. The data obtained from this exposure assessment investigation are important for several reasons. First, these data allow for a better understanding of the exposure distribution of serum fluorochemical levels in both the chemical and film plant employee populations. Second, these data may serve as future reference regarding human exposure assessment 601317 EPL00a0m6 for the film as well as the chemical plant in the area of health studies and exposPuargee 39of 85 reduction. Third, the data may be used for the construction of an exposure matrix for the anticipated update of the retrospective cohort mortality study of the Decatur employee population. Finally, this study will allow for the opportunity for employees to know their own serum levels for these seven fluorochemicals and encourage further practices leading toa reduction in their serum fluorochemical levels by the variety of exposure-reduction `methods recommended in the Decatur industrial hygiene exposure assessment report (Logan, 1998]. 001318 EPLO03DMS Page 400185 REFERENCES Griffith F, Long J. Animal toxicity studies with Hyg Assoc 1980;41:5760583. ammonium perfluorooctanoate. Am Ind Hanhijarvi H, Ylinen M. perfluorooctanoic acid in A proposed species difference in the renal excretion of the beagle dog and rat. In: Beynen A, Solleveld H, eds. New Developments in Biosciences: their Implications for Laboratory Animal Sciences. Dordrecht: Martinus Nijhoff. 1988:409-412. EHamnpsleonyeKe.s aLtab3oMraDteocraytuRre.porStt.: PAanuall:y3sMisEonfviFrCosnmiennStearluLmabSoarmaptolreys.CoJlunlee,ct1e9d9F9.rom Logan PW. 3M Decatur Fluorochemical Industrial (Unpublished report.) September 15, 1998. Hygiene Exposure Assessment. Gilliland FD, Mandel JS. Serum perfluorooctanoic acid and hepatic enzymes, lipoproteins 568. and cholesterol: a study of occupationally exposed men. AJIM 1996;26:560- OeplisdeenmGioWl,ogiGiclliinlvaensdtiFgDat,ioBnurolferwepMroMd,uctBiuvrreihsoJrMm,onMeasndinelmeJSn,wMiatnhdoeclcuJpHa.tiAonnal exposure 0 perfluorooctanoic acid. J Occup Env Med 19982;40:614-622. OpllsaesnmaGcWh,oleBcuryrsitsokJiMn,inBaunrdlehwepMatMi,c fMuancntdieoln JiHn.perAfnlueopriodoecmtiaonloiocgiacciidnvpersotdiguacttiioonnof workers. (3M unpublished report; 1998b. hOelpsaetnicGaWn,d BluiprirdisclJinMi,caMlacnhdeemlisJtHr,y ZteosbteslinLRf.luoSreorchuemmipcearlflpuroordouoccttiaonne esumlpfloonyaeteesa.ndJ Occup Env Med (1999, in press). Roach DE. Fluorochemical Control Study. Paul, MN May 25, 1982 3M Unpublished Report. 3M Company:St. Schuman LM (1982). Letter to Fluorochemical Control Study. Dr. Frank April 29, Ubel 1982. (3M Medical Director) concerning VinolHlummearnD.SeQruuamntibtyaLtiCv/eMDSe/tMerSm.inSaatlitonLaokfePCFiOtSy,:NPoFrtOhSwAe,stPBFiOoaSnaAlAyt,icPalO.AAJulaynd19P9F9.HS 001319 EPLO0aOmG Pag4e1 of85 ACKNOWLEDGEMENT The investigators greatly appreciate the contributions of Kim Young to this final report, 001320 FaEaheirooors Tabl1e. Randomspe sestonbyDect departs withpercent aticipsion Deptumbsr Dep Name Empwilth 0o90loysstioen cosdes ToulN Semplesize YPeauricipu0ed) ky MDyemReDeecd 112 30 s@ san 7a6t20 DBelcdagtu4rOBpedrat2iOonpsersions 2i 1 1m sao "60 Deca Bldg3Operstions 113 0 sE san 0 DecBldgaiNtOeurtorns 60 is Ben 209 a9 DeScMaDMatimuSArRC 54 is wey 10 aaos5s7 Ta04 PMrSioupgcpleSyCehIiaisnnRPersoncoeusrseeEUnr8igrOcN Deca SMD Chem FactoryAd 2 1 x 4i Bey sa 77661065 id DDDeeecccaaatttuuurrr SSChMMeDDLmCoShghiimp RcQesvuhasAeys+s. 2245 1] 7522 DecaturPCPD FFAdmin B s910 Decatur EHSER Employesrgariessof090or 190 ocion a 5 5000 ow 22 as5ss 20 & i254 ``oAAttooo&&&CCCrhheeemm MMTiiNssPEEInnRggD. to&Chem T Mig Quali 5s00o) ns 41(0110500)) we ian 8 es A ChemTo CMGMiE (150) WaosttewatereatmentDeempclaoyeeWsaste Trsiment ` 5 sam 00) Ta1bconltinueed) Depthumber Dept Name [snr------Deca Heving Plot Film plnemployes Allremi1n90iocaniogn Departmentcodes Dineen TTR [-- FwEahmieoo0osfss ToulN SumpleSize 10 4 VPeasnicipu0ed)Ne 509 ie - say nes 2s 5 Tesdo 209 g8 88 EspLioooeens "Tabl2e. Number (nd pec)ofandor sl, luce dl ican chemical plbyedemogrsaphic harris sump v= 126 Volar 1) Al Paris8 = 187) Genter N 6) Ne Female 2a4 a9 oinn CyThWeoomrikeed a Yo $ @ GuCCaalteimoen rOopser 47s on ENNiinlmgOperessr 5i5 do SWSeienrreceOnypeera i": a N 6) N ) 29 5as) IH33 218) n3 6" 0w @ ii. ao "55 aco isi ii@o u7s a i0 @ 2%s a oLgoEnCigeemOsocbptirOeprmor 97, @o 02 a & EFtirimicenrns ai3 I@ fi} i2 : i ao 8SSicGprreyeennt i7s a pi| s @@@ Wane Opera 3 @ o nEt5 Pb@io 0%s aio is57 @ wEhmioo0s Fa 353s Table2, (contaued) Sunple N=126) Volunteers (=16) AlParicip8as= 187) Chew Gum ~ S`oAmbevtayismFersequenty 52 2) -- x o aa9o u eoyy x 62 oan Rarer % Go % @ 5% CheVwerTobaen No 1015 a5s 85 oao0 1525 a09 SmoYkeeuCigars No 8a o@y iw [a2y 2sss on HanYdeto Mouth Contact No 5 o 21 aonn E1F} &" WasYhesHands --MNeo e 0o3 5r aas w is2 aaIoy, owwa oaeom n S8 88 woPtwssoss Table. VPearcdtaDge ofelyreboihem random spe, vhsallsiba s sponded ty sureswokad ver CiumnntygWok sN unpevE =120 VN olee (N=6 AN PNatl i 04-18) 3: 5 Ros 22 @0oy FO a2 GaGyo9 3 oy o5 on& "oy pIv i-- sisi n5Bo oGe x Gy 52wo G9 a oy 5 ano a0y Bo Gn F2iim Vanover aB5 o may Wom uu 5 o a 9Gy wo annooo aydg FI EivnbeiunWnogrgk.e.d Nxso upeoon owN Vooy ren WM N paiE T ns S2'o0s sx0s a2no &oGwy 2 oo n s rRw w: ao 0 5 na G w wo g&g 8 wiNie ahe a2m6 x@ B Fs I m y a oy m 6[A lGo 5 a 61 @ Bo a SF[B ierlwmeewe a2b1 a0 y603) 7 12"Tm a6 0n)9 a6xn0 G6a0h2h) FwEanen7aar3s Tabled. Seam fuochnicl ees pmofan)dor spl,solesdll peticipn hia ples Raton sample Voters Alc Mem GomMaormic Nebo Ruse Mem -- ew Men Rage an ["ve--e vei rue FOS IS 0% LM 060 129 07% 08m Gom-ss0 Le osm ams 0. teee HES 0s 00 om ams 0m am ems oom om am 0 ocor-ime TOM IS6 0B LW Ome 106 0s ows oms-4sw Les ows 120 oars--gme FOAL 0G OMS OMS OMI-00 002 007 owe GoN-036 0m 0005 oo oaoroae MT 0m GO 06 Gom-0sn 0m 0 ow eom-am ou 00% 00m omer HOSA 0m G05 om: oos-aez 0m9 ows ovr aso 00st 000 000 omor om --M_--ON 02 ome Goi-a% 7OM T0mTTGon T GoR ne T oom m om taomn sooeore-omse a. senifany iin p<.09)geomet mean anvoles, senscs g 888 wEFnarcaests Table. Demogptic cohcmraeistsofOouummmeel Jb G5 WH ccobrUiEas of of nd sample mEeTne 1o26a)otf chicscelyes WEN SdpG iete m awaye axf deen r w 4 B= woo oww "lie e w"hi epa3a Wei5Ne Waof Wip S% pbi5 mabSe) nn fe 25u01s whw SW ehom n pe w5m ow7om WS B a3e moowle ao3n Ymo yVaata wie als eitee wit alts aie bTBS=eS n wpi2we iS In Si;5 h "%: hIP|n a a "o FHw5e e obWiws -- f=ae M0 wie Nee xe xe Ne wpme asEw deme 4iBm ne 1380 wes nog IaaWy womo, Aoy(5sVaan sinton i d Mo owme wSeE sSe EMwa Ewma m sm u,en 2 Bow 8 wants w Wo owwe mNeE wSmH w8 m m0 ewee sgee SM Chee 3W6"w em wMeBr e4eGn nw e a0mbey se Cto inyidm epp<< 5dep eeail aEPMLooos Page 9013s Table. Mcheeamni,cagleeommeptlroiycemees.an and media ofserum uorochbeydmemiogcraaphlic charctrsis ofrandom samp(lN=e 126) of GeFnedmearle Male pros Men GeMoemeatrnic:Median 0166876 004m9 0143102 Pris oar Men GeMoemeatnric Medi Men GMeoemenwic Median J 0O3n8s 00020s 002032 0m6s1 0i3l6a --0r--osve HYeasTonmoudth 136 LOE No 1810 06M 0L9O5 002d% 00118 o01l6l8 1lesne 0o9e iisast WYaeshshands No LML700487 0LmI 0023%0 0o1n 00112% 11s2;6 o0ms s13w0 cWhoermkiecdalonly in YNeos 1M9B2071m2s7 32S 83 0I7S 0o2s6s7 o02n1s0 0o3u0l6 1139077 oLmuee LLoese Table. (continued) PROSAA Men GMeoementric Medion GenFdeemrale Male Q00O6 00000130 00000029 HYeaTronMoudth 006 0009 0008 No 0019 0007 0M8 WYaeshshands 0s 0009 0009 No 007 0005 0003 inWochrekmeidcoanlly YNeor 000024 00000060 00000088 2 &rrru--es 2 Ms70 PrOSA Men GMeoemeatrnic:Medin Mean GeoMmeetmric Medi 00017675 0000K5" 000027 000083 000023 0000HM 0O11533 000805 000861 00005K0 0000132 0000M2 008152 00005 00662 000065 000030 000039 0011620 00005 0000%8 0000569 00001M2 000013 mEPMLaoos PageS0orss sss Mem MGeoemetnric Modis 00005s% 000031%4 oooorm 00008% 0000%2 Oooom 0000%0 000036 0g0e2r%s 0000568 0000179 oooor3 fwBowcs Tabl7e teetrnenssshso mreandommea palnd(915-51o3)fcremcoemeticmsnof em rcels bya caretjo og oWcra ET omeml EaUtEah MmEem ofammm sweyy SlGOei we oe No GSdm oaiee onume moiwe ole oT te odT e eer 0d ommaaee eolmm omoeen oontn oglne ongse eegel Sn GSeEm onwee osTm oobmo aoTwen oeiees oomlen aCiTe eon adm 00th onthe otohse ooomden oodmiene enpteir aaede? vouMoo oanne osulaie ooime ao le n oe aadsa om ne e ont%e Gweelm onalrin Ta oowlen euTme odene ogeTes opleer eilse moos eomme aenm' ooomn ami oamtrwom oneens ouomar GSEmL oolocomon oono'imon oooCeton anoiowhten ogousnt aohmea ogmnp aseeleSens fo 2SS RaMnegme. 88 WgEm 040-003s0% otemh ooolb adsem 000092-29099 000080-704.410 aolme oodut GGM02-608T0 O00S4-5O.NS 00000-30907 00otmeh 001o0a-053 oo0s0y87piss ognet eneeed Table. (continued) eroNses Rage M6CMLe.n 0000I0-0G3OI 000o1m-04 OMI0-00708 001o-0m05 007g-m00s5 002o-0g0o10 00o-00ss5% 00o3-s0200 00o0u0sS 00oIGn-eaMO neseVRiuesne 00oMo-n0NE o0MIo-ON0 OMoZo-017 OIoGn-s0M6 ooood-00s --OMCIGMLeC_nL_ON00-0o50-0oN21S8 O0U03aR2-g0O0u61s 6000006g-g00g15 OO00M4Io1--01o335 00o0o6ngi-o0ao0n1is5 ah)comparisonsfo cach currentjobcategoryusingstudents p<0.5 WoSus0t00 00o-a00% 05o-oi6s 00 0_0o0og3s-ogo0o6m aEPMLoons Page20185 0oooosisue omouset busooorn 000osboe ooo00wne oot00h7iss 0oos0yo7o-ioasomno oooiottoagneoss 328 88 sErmLooss Page S3of 5 "Table. Fluorochemical stios bycurtenjob cateforgranodormsaimpeles(N = 126ofchemical employees PMreaons RaMnedgiean PrMOSeBnOAA RaMnegdeia PrMOSe/aAaniytes RMaendgiaen MMTeOnM RaMnedgiean PFMOSeAwAMSSS o RMeudiean 2 rroMswennssss Medan Range GeCel? O59) 3530 139 i15o0 S6216% 490933 233s 2075 0o3s OISI3 0014 004-12 OChepmiceal Od) 5s2 L-MS 0099% a774 13-6IS 3307 0S-as 0029 00-85 3003 083-307 EengLiinbe)er! s52ot 16S 2i72m 3a5m 05-368 s5a7 MeSMA 0131 04s 0235 003-183 Mien! Opnrilot Ne) Me) Saray Swopner Neh ei oWpanep ee 10s3ave 376s 43g5s-e9e ogss anna 5s3o aeons 6n6e sens A1132FF0os sY u Y2g 0PRgPCgisPL 11400 5a2 LHI ao3r 250s 9or 32097 1607 1aiiuz 29530 os oes 2373% 12787 saa3 v 3322 tas 224 s23 leses io3534s o0s1 001-3 2230m 02-57 0g2p 005e0s 0L5ie ocean 003s orow 0o1ar 2716 2275 002-27 08-823 09-37 043 002-641 0236 003-118 wePnreaSohoosrss x Table. Deamoganrnpiitc charte[rseofilnongsjob a oltm ctggiriemsofeadosamploe(ae3m- 126) wn a of hSeaiyplesSFwai ey aT Owpeas Te a"nl&Soenn l-"Wa oa"l2a o"Iu n23tIss oa"6Tus ala= whEi2Nn rSe5ewanm W2aahss a aau1s o0moh Erudid 2wa%1 w32iih =5uins vmjarnees 5 uwhh en Pi a7: u:to i ETsn u5x uao f= Got Niw N3n N1on ini Nn 2a5 wow fia) Ww =: aw Taoe ony Wakes 5safw WsGa Wo a wonTaae co am o1a &3 oo ebVmya a nEI ow sion ua HoR w LTaw same c3o8 ow ok3my 2PmE won ow Wanitos sPwe trea dswe rsmm aom P2gyw a5 a si a u? a6 HLyEEdE ETE wEE1g 3) Sicgomnpayniodnisfioerncsapcehrcleonngaegstoabmotnegoonessinogbcseernisc,po0i5 s, <05 aEPMLoos PagesSorss "Table 10. cMaetaeng,ormieesdiaamno,ngg reanodommmseeaamtnplaern(diN95=c%1con2officdh6eenmciec)ianlteervmapllsooyfgeeseommeeatnorf siercum fluorochemicl levels bylongestjob OCpheemrical ey EnLgainreer ove MiiNnieenancs' Opweiraltor Secrery SupMegrmston! Ne Neg ot) Opwaesrtoen -3) PrMoesan Range ON2E0-87840 0o0-s1740 0229215-010600 020o0n-s2000 0oI9s-sLUD 0009313-6120 025263-848840 GSHMMaCnL LMLO-e19t% 021g9-e04s96 0LIiMs-p239 0MoIs-0sB2 DI2G9-05Ss3 0o2Bs-0007s64 02415-3766s00 PrNisew Rage OoOTsIe-LBO 00o0i5l-s00 0302-9712 0080-1017744 00Mo-on017 00o1s0-03 00s025e6se GSMCaLn 031o4-s048t0 00g-e0e1n0 0100117-g0307 00o-o012 00o8-s007 00o-or0193 00os0s m PMoaen Rog OIE2Z-96760 OS0-2m1000 02L16-647680 045L0n-230 005a-r0y261 00041017 90 093262-119680 GIMCaLn L4L-2o2m9b5 0IgN-o0u29s5 0-1212900 L0OL-e16tH 007on6p-e0t3s 00o2-r05s10 088L-o4i16s6 PrOMseAaAn Rage 00010-2029 000o1o-007 00010-00 00o0o4-00 000010-002604 00o0on-009 oom000c8ols GSSeCnL 007o-0n016 00o-0s0t10 0OoMi-00 000o9i-002 000o1-o00r2 0g0oMo-g007 0003000s60l6 228 wmMem Ram 0M0921-309 0000B6-00I6 0002-60971 00050-60MS 001o0o-n007 0o0lo6n-021 00%01-0asisy 8A GSMCeLn OUHo-0n16el 008g-u0e06 0o16a-03t15 00o-o002 00o4n-s004 00000-s0096 003000-905177 Table10 (continued) ProMseaan Range OoIom A OW00I0-16006 0000109-5062 SGAMCaLn O0IZo6-m00M0 00020-000 OO0-0100GE MssMeean Rage OWIo-oOn3M0 00o2o-0BS 001o5-n0406 --RLCSGLMAe_CaLnOIDOM-090-00m04M O0M6-g-O0pO0Ma4 00008g--0g1g3 (wh)comparisonsforcachcurrent jobcategoryusingstudents, p<.05 0020-0102204 O0oIoB-00M 000020-03045 00o0m600-100m0i1s5 0090-00080 00o0o5r-003 000o3on-000 0o0o3o-0o00r017 000002701 00000-0002 000-010909 0o0o4ooo-ino0e0r sEPmLooos Page Sof35 oseoeoer 00es00r12am oom006a7isr oooo-0g0ni3sme 82 8& ohfomie Table. RalfBroce by og cigs amen reo se 3-126) hic clos oni Engng wi Spi ase Operator* N=57) Lab N=21) Maintenance" N=14) Operator' N=14) LL Secretary (N=6) LL;NY1 Mgmt N=7) Operator N=3) --NMe eeat--n e i5048 fEiea f5ead B3aeger 0i5h64 W650M 492 NMe eeana at5Lobes wi23e0a a1Lsh. a5oe3ghed W32B6% B332656M,ete 9ot,eer ojeosn m 1i54 53 ate elle f55n oaaJths $2 P 35s W, 252 Misuse PjrMooesaanuNss es338ts fS4ep t335nM w536f a337h db5a3hr 03320 ogm MNeiank a5n093e* s ow5Llts a05t7a at523hhees a50e32 s dIH1l4 a oo0tf2h 8 wosnsss & MReMheaeatnwtea oopm2Hp6i"mrroomn23ot2mwss eem0oaof54ar eobsty74hhs oosr32hs6 sr (0)comparfiosrxohn longest ciety wing den p< 05 oaddoiFlueel r oomd3Lleasr EFaaeaSwsorss Table 12. rMaedaonnresnieec(=o13m6)em cahneamdiec3a5l6cconlfideoncewheercaelmosfsgaenyowmomkeeactorrfnicrcdToor(choehssong ros oBtls, Bdne" obeys B"RteAntK B0e) Weser NRee omolsim om2eauo o2w7 iehouen a 20m owdeie Go9vecelm rus oommioss om13i0lsim e2r0sie osocsasrs aLomn onIi NReee on0ion oooimemo oooss m omoimem ooesom omoissiae GHCeL ron onotnsom omoimiem oomaenase o0m0sem oowmbem oomimlime NReewe oomsistim oniine0 eaem e od10ie oa20mth osstohme Gaceln rosan om0t0om 1o2m5 m 2amen odLiiiner i2aam onLtmhe NReuwe omiolmomt oomuicsoms o0o05mslom ooomaoaon oswosiaon ooinoban 2- HGCeLm omomolmomo oolooonms aoobmeon oooo n orooen s oomren rg 8o e M70mm oaonm oo0oTmoms oowmen orodmTem ooime oiolmers 6HCveLm osdoToonnls 0oomoms oomimcoms oomomion ooonmtmis oatmtows FaEweneoSpsarss Tabl12e (ontined) rNosTeaamw OoWuSSs0N 00ao3n06 0o0i x eaoloonemn a0on1ewr oioohon GHCvL wise omooem n owioocmoms ooosscom ooolososen saoosiws oomnse Vfeen oomonen oowooms aonmsiom onoiomons omaenens otoosie s aHvCiaLn oNo0oSrow Vesinchemit ooioommi aoosoimoons owooimoon soaloees osoaom Menem ww uw s s o5 ws u g 58& 3M EPaPgIe-060006of 85 Table 13. oMfeasne,rurmanfgleu,orgoecohmeemtirciaclmsefaorntahnodse9e5m%plcooynefeisdeinncreainndteormvasloamfpgleeo(mNet=ri1c2m6)ean `who said they have only worked in one building/area PFOS Mean Range G. Mean 95% CL PFHS RMaenagne Bldg. | --ON=6H ) 0.474 0.129-1.700 0302 0114-0797 0010.31-107420 Bldg. 3 oN=e7) 2561 1450-5.120 2293 1453-3619 0.1501.8315.860 Bldg. 4MX o(Ne=3s) 023005-201838 0.554 0340-0904 0.030.80-603.152 G. Mean 95% CL POMAeAan Range 0.064 0018-0223 0.164 0053-0386 0519 0.185- 1.450 3021 0366-6760 0.0309.0-604.103 0.415.00821.850 G. Mean 95% CLL PFOSAA Mean Range 0.125 0053-0294 0001 0.001-0.003 077230-353351 0.030 0.005-0.118 07119.-0310476 0.020 0.008-0037 G9.5%MeCaLn. Ms70 Mean Range G. Mean 95%CL PFOSA Mean Range 0000.100-10.002 0082 0015-0201 0.053 0018-0159 0.023 0009-0060 0.00050-106.047 0.06033-108.480 0274 0145-0520 0.158 0003-0569 0.00080-105.027 00206.-0400053 0.0208.-0408.081 0.00010043204 9G5.%MCeIaLn MsMs6ean Range 0000.90-190037 0.022 0.003-0.585 0.00090-505.324 0030.30-907213 00110-.00.31408 00040-0010019 9G.%CMIeLan YeaMresainnchemical 0000041-40045 2 0.004.20-709.150 1s 0.0050.-001.3034 16 001339 nEPMLooss Pagelofas "Table 14. Age, BMI andyearsworkedinchemicalamongcurrentjob categoroifelslparticipa(nNts= 1i8nch7emi)cal Ocpaerltol OChepmiecsrl O0-N 9) COeen) EngLinaeer! oeei)m MMaoeneiemns! OpMeiraltor Seer' M(hee20) (eNeSs SpMenmiseorl oevae AreMean Mesdeian 2a1 " aa1r2o @a1o5 a1vse s13as g1q3 a1g2a Range ss Bw Bem mem x2s wi"e ute BaMean Mesdeian 5183 76 a073 [243 23 23 2063 a1r1 n03r m1e1 Range 15-30 om 16om B26o6 2w6e5s al2k0 2w7e6e YCehaermsiWcoalrked In sMeean RaMnedgiean a1524 i1e1ne 10 1292 Ww 2% =a in 2i6e 5 op s sp59 ' 2a10 24 --_--_-- 3 1m 225 -36 TT (4) comparison forcachcurentjob categoryusingstudents, p < 05 OWpaestrea eesss g07g we50n 5ia a2s53t 3is i1m 2 Q 3 sEMooos PugeG2ofss "Table 15. Number(nd percentage)ofdemographic characteristics amongcurentjob categories ofall participants (N = 187) in chrical OpCelelr 0) COhpeemriacoarl vey EngLianbeer! Mumewne OMpiemlior vn eerie S0e-5c) u Subpeermson o-26) OpWaesnteer Nes) GendeFresm Male 3a6y9 snea)y 290069 n0a0w a3E0)) s00ao B3E0 esmao COhnleymiWcoarlked in NYoer G5699 aeen insne) w2ae)) 220 416000)) n[eCyC oo HCoannsdetot Mouth YeNuo 0@9 wuoen) wweaey B10oo w0e)y 326000 sneeyy 236600 WasAhlwHaanydss 389) way Lessfoqunty 101) 519 nBeoym s2a0y9 nsea)n 230600 B0E0 230600 -_-- Sinica ifrnt(p <0) proportions betweenjobcstegoriesh,i quae test 282 2ig aEPmLooss Pageaiorss "Table 16. Maemaonn,graalnep,argetoimceitrpia(cnmNt=esan1a87n)dof9c5h%emcioncfaildence intervalofgeomet Ocpeaned OChpemeicra] EnLgibneer Mime! pros &=) Ney acy) om MReaagne 0-2266680 0191-5379260 000-61110 02911m-40 GSMCaLn 09L14e-n2s93 125L5-O17O0 020-3000M 09L0-a1p9 prMiesan Rage O00B7LS0 0oGa-n10 00r05y-0905 0050-3019200 SGMCaLn 0MO6-g12e1e4 023g9-0a35a7 00g0-o0s11s1 010g7p-0g2e97 PoMaean Rime DI16s-360 012510-96760 00043-62330 02s-n460 GSCMLa.n 061192-g257 LSLWT-2e14 014r1o-0p2e7s OMgBIg-LER PrMoesaanA Range 000o1-o0051 0010-0102269 0000101-0003 0000103-70125 FGAMCeIaLn OMIo-o0m08 00oM-0hMD 002g-a0r05 000070-1s002 S&msMReem 000012s -0 00092-83810 000M0-s0t410 0002-307701 GKMCaLn 00o20o-m005 00or7g -01 00g30o-n005 010o-0i36e7 meanofserum luorolevselsbhyceurremntjiobccateagorlies OMpeinler Nee 0So-s200 OIgH-o0r6Te 00[-303 00g3o5g-e0a0s 00I1S2-1283M0 068o-g1r45e7 000030-2005 00o2o-r003 0OB00-s0NS 00%g-0g047 Seca' SwMpeginstor/ OpWaesnteed o-5) 6-2 Mes) 02040st-10 00911-m1060 020206a18sso 02g0a6-g0e6s8 0510g-10e88 e04s95 seess 000N0-706172 00g-g0g13 0h0391%a0 001o0-u00 oomosis2i0 000gaapmes 00051-607261 0021i28u9so 09m16a63mo 0106I-0s23s6 0ge3pp1acmtes Lo gepss 000010-002008 0000-01002 0000I000905% 000s00a0o9is 00000s0ses 0000s00e6ons 0000013-6007 0010100-05 oss008m7ise 00o15o-0057 oot00060%% 00soomma Table 16. (continued) ProMseaan Range CGMLan 00000005g-0015 0Mo2o-n0M5 00-oo0s4s87 001o3o-005 000o-on0063 000o2-n00e05 MsMsean Rage 000030-30035 0o00o1-n030 00o0a2-0033 --OPAMGCMCaLLn_QO0G00o-6-n00i0017 00M0-3o40-s000s5 00007g7-o-00i00g114 (ah) comparisonforeachcurrentjobcstegoryusingstudents 00010-0065s69 0o00o5-0027 000o8o-s0s406 000334o4--s0008s858 00050-00s204 001o-or0035 0020-010s045 00O0M0g8-o-00n00eM14 aEPMLoots Page6i0f 5 00o03o-s0080 0000050-520612 000so3osl 0OoMo-002 0000}0-00701s 00oosnoi 00oMoi-s000 00000-s036 00m00i87ss 00004o4-o-n00027 00o1i0os-oo00ur2d0 oaoorl,0a-0o7smess_ 82 a8 sEPmLooos Pa65gofe85 "Table 17. Age, BMI and yearsworkedinchemicalby longestjobcategorieofall participants N =187) inchemical OpCeplo OChepmiecall EngLianeber! Maen' N=) ONT) mesh Ne) AseMew Mesedan 2"5 is a10 a20e a" a ais Range atv 38-46 Be Bem mes sMeean Median 25148 20 200s 215 8009 27 n077 27 Range WB mew 2% wn YeCahermsiWcaolrked SMEew Median in57 1i1e2 2i3e 5 2y5e6 Range 225 ft} a} 1-3 (0h)comparisonforeachlongestjobcategoryusingstudents, p< 05. OMpielr' e200 s14as n2s 311 w2i65m oPseas 1'a Seecrnecy yg17 at"s 2112 at51h g5g7 2@3 Sunpiegrsmotn, (ver ape1t7 r masos 3io e2w1 E33d 2} g2S 2= OWpaestnes es s23e w5s2 6294 no25m3 u68 a5n wEPmLoons Page 66of35 "Table 18. Number and perocfdeemongratph)ic charactbyelronigesstjobcategoriesofalpartcpant employ(eNe=s 147) inchemical GenMdaetres Fensle Ocapre N=) OCMhpeemeioc)all EngLinaeer! Mamennce' Owpieln' eid) oe) (ean Seernen! Swbegnston ois OWapstne ee NJeGo) 8Ne6o ow sa2) 5N0YH 39 00Ne0o00 oes 2NeGd) S49 0N0eMo) 700000) DNeigy 30 N3e0o0) ow iOnnClhyemWiocraklesd NYoer 216679 BwisEn AeEy 006)0 u20e) 3 an 3766)) 3oa0o00n0) CHaonndteMouth NYoes 3o0w00 1s9e2cs5)) u1a) w66o0n) Wa"sAhlwHaayndss 267) LtesesPrfogelny 11003)) 2120068) NwGOesY 3e3009y9) * Significantly diferent percenbtylaogngesstob categocrhiisqcuasre,p <.05 naess 3166)7 SS06600) a00o) 4n400es8y) 334@607h)) sR a06n0) iT o26)w Sg h&y a ies TR 1.Mr sn, ns, oTme ec ennd35 one lo metmen Bsry ges bcc ang ws oE com W gGmatEEfeteh eCuem ogtmhe swyy CTEE wie am RHee WGeEn owame oanme oadwe otaee atwBne 0omm ooew 0ohm ani ofarte tplohs daTe oedeee oolmeen egSe eid wybee aLlEe oeomf lome oedwe aalm oehnm otoms onodme WGlEen | lodacth waTws lsamnt GgmWs eglm a gg egTga aoad voME oo on em wdafme owlee oluese mlame oame oetee oiome WGEl eh ae e oe oodm ome er aml aolme 0 ga woE Vmo we em ealmee ewtnn aeom ouem oadme ow od o oud 8SWGElen oo n a foe wedw oomte osott oomne elamie oand EEBOweyE wmeeowP awee oeen owne oeoen 00aem onowt GWlEen aeamt ae aolede oonwlt wsalte ogthme nlgee aoato? EFaacaoverss Tabi. ond) mosNRseewe omoimos amoime owoems omiocween ooenomem oaomm oohmm aodotnheen GNCeLn omow' aoowc owimtoMms ompittew dooomms omigouumes owlguemes omohmen wiYseoRenw oiolonms omeimim ooolomme omoiomews amboowios osecinhmo sowobna ontgunier lCSehCmL oomogo"oGwe s_eooolnwGooenmn oomina%ioowmnn_ooomueeoaosowst_ow_aioConhzoormsm_o_mhoimioosuoen oawosg woriumm orvteoouomgem a)comparisonfo cach ontjo cig using sens, < 05 gg2 82 FaaEhweisoooers Table20p.riMceinp,arnatnsg(eNge=om18e7t) wmheoacnumaendnl5yw%orckonfnildeynceanneebullodfinggmeeohmeemamnioefsetrumforseeofall ros aBig)1 BaiUnS a Ba BoAanX BoEs)N WaFseywssr RVoimne GosOsL on29es 02036 0 moosts6er es20om s on2i76ree GSCMeLw ous 0oMns0 L1mI s2e00am omaieess m1i97m on136s0 NRaee WOaBiSsOTI eooes-m im0 a0sI6B7iM0 aomoicome ioais m ooisi GTHeCLm roa 00o9n-0 0omstsm osoaarse oo0w0seoom ow0soam oodrmin RVaege 2onM s ne1i3en 02d0i6c5en0 ow1S6amo Le2ase aoLmhme GHEaLm rosa OxO0M o1m2e0n s2aam m oasaociss n2s0ams onLdehes RiVnegne OOoIonSOH 0a0o00S 0000020026 0o0o0d aaomooeos oo000hor B8 OSoCvLe 2 wn oo0m0-0o2ms oami0-om aooom-noms aooowsvems ooanontems od000e7 m & Reane O-a0orAID 00r0s-01 00om630 mai0cas aoasmcsems aoanohnuss GIMeCmL 0I0I0-00US 000-002 0xooa-aks ovawmosoow osonomries orooMnoms aEPMLooss Page00135 Ta20.b(clonneed) prMoesaan Rage 005oo-i0s161 00M0I0S06-001 0000310-9035 000oo-z0e204 00032-51048 oss0007pon GSMCeaLn 0000M0-5000 0020-0003006 00-o0o066 001001-07028 O000E519HS oo00m0w6is MMssen Range 00o-o0n17 003oo-r037 00o4i-03M 0o0o-n000 0m0S07-60ns ooroossis SG MMCeaLn 000-010300 Yeianchremiscal 0000601-0007 000T0905I5 000001003 000l0o5m7ie oo00a33i --b NMewe__2 0 Inw 0s3 s n m i g33 23 aEPmioons Page 710185 Table 21. nMoesn,ebaungielcdoimenitgn/cmhaeerminecasalnd 5% confidence nevaofemetmeia fco all paicipa(ts= 47)who sidtheyhave only worke aBiiosn1 oBitsy3 Bi[gg ihx broNses Range ooam n Lo26s3s ooosrseom SGevl o10o-m0s9 Leo20i7ies osmoiicrosm pNenes w Range on010o oosxcoil aoousa SeMerm oomo-ssom oomeslmies ouo0isos roNairen Range omio-s0sM6 o2s007e ooossemism s6 everm omosn-s0m o2l00e9 s ouoranies ProMseanw Range OW0I0-0030I oesoamus oodo-mo0e S SCMLe omi0-002on oowsooms oil00a7ns 3as snRMaenge om00a2 ooos0sm 002o5-u0061 6 Me oon oz oois Table2l, (continued) scl proMseaw Range s0mMcen wsRMaenagne e6Melm ea omi-oow oim-o@ oms-oes ooooson-om0 omo-o0m0le o00t0007ss omeo-ono2on o0iosBt0%5 0030-0s0946 005om0s21s 0000000n6 n 00oso0t 0s 0e0o9o-i0sms 006o00ism oooorn-ao i aEPmLoons Page 20185 32 aa Teomn AE eMnnlebf eri ponmd te gy ct ro hm pen oe rome rita se booeon u3ahs ut2aa a3w'o ow3ao i.i. xmn a a 2n YForoNot fFeo) bia us Ai hii s 522 ETMPMLoons Pagersorss `Table 23. Mcehaenmi,caralngpel,antgemeplooymeemseewahtnoasrnedci9ur5tc%entcoonbfiwdaensccehienmtiecrvaalloofpgeraetoroocamgmieencatenrorTfashiercum luorochemicablsy gender for random sample PROS Female (=Ch1e0m)ical OperatMoarsle(N=37) rats Female(N= 6)EnginectLabM.ale(N= ea SENA rereMS 17) RMaenagne oanL-i2s3s 80 049019-673260 010101-607281 009057-919740 95%MCela.n 076410-5114047 1345L6-215962 011051-507214 033065-400368 PrMiesan Range. 00710-1094004 01304-412860 00005-002081 001082025005 G.5%MeCaln 011091-602735 028503-60465 001o1-o0048 006091-201210 PoaMrean Range 010-132012100 074524-967760 00305-100300 008014-723320 oG. wMealn 070011-2198018 182201-628570 0083oo-r0141 018602905.468 PROMSeAanA gS Rem 000o1o-102109 000100-401265 000010-004018 000100-107073 a5 eMsecm 000020-006016 000o8o-r002 0001o-o0n005 000o4-n0s084 msMenan Range 00o29u-s0357 00090-2600992 002000-406093 000800-804410 6o.s%MCela.n 005o5-s0?139 009091-406217 002400-309064 003300503.084 Tables. (continued) PrMOeSaAn Range osG.%CMela.n MsS6M.ean Range GscMlea.n EE -- "p<00s 000030-603315 000070-20062 000o7-o0n118 001040-207050 000011-009487 001060-300055 000010-803380 003050-800073 MEmPs Page 50085 0000oo5r-?0063 000010-005024 000030-100027 000040-007014 00oo0r-?00.0560 000020-004010 000[ 2-0127 000060-100019 3s 2&a MEPL0006 Page 76of85 `Table 24. Distribution of film plant participants: random sample, volunteers and all participants Have worked only in film plant RRaannddoommSSaammppllee a2 Film Plant VVoolluunntteeeerrss 14 AAlllPPaarrttiicciippaannttss 56 (Have worked on D-1 maker) [0] @ (Have not worked on D-1 maker) [5 a3) "9) `Work in film plant with previous work in chemical --_--18t 22 220 Total 6 16 76 001355 aM EPaPgLe-07070o6f 85 Table 25. sDuebmsoetgsr:aepmhpilcocyheaersacwteirtihstoinclsyoffirlmanpdlaonmt seaxpmeprlieen(cNe;=e6m0p)loofyfeielsmkpnlaonwtnetmoplhoayveeewsoirnkcelduding on D-1 Maker; and employees with prior chemical history Age Mean SE Median Range All N=60) 46 Li 47 23-59 Only Film N=36) 4" 15 46 23-59 D-1 Maker N=6) 46 3.6 48 30-55 Film w/ history of chemical TMN=18) 43 21 51 28-58 BMI Mean SE Median Range 280 06 278 180-418 282 08 278 180-418 269 19 27.5 217-317 280 Ll 27.6 200-379 Years worked In film Mean SE 137 137 100 17 92 41 154 24 Median Range 14 01-360 14 01-29 6 1-21 16 1-36 Gender Female Male nas) 9 ) 6 an 0 @) oan 5@) 4@ "8 Current job Engineer/Lab Film processor 16 @) 23 (8 10 @8) 2 (3) [IO) 5@) 6 (3) 6 (3) Maintenance Administrative 10 a7 nay 7319 719) [ER 2 ap 4@ Longest job Engineer/Lab Film processor B@ 26 @) 719 15 @) [IO] 5 @) 6 (3) 6 (3) Maintenance Administrative ns 0 an 8@ 6 (an [Ei 2 an 4" @ Hand to mouth contact Yes No 7 23 G8 6 (1) 0 ey 46) 2 Gy) 7 G9 non Wash hands Yes No S083) 0 an 23 18 5@ 6 (100) oo 16 (9) 2 ay --_--m---- 0061356 Mm PEaPgLe-070806of85 Table 26. PROS Mean Range Mreaanndo,mrasnagmep,lgeeoofmfeitlrmicpmlaenatnemapnldo9ye5e%scboynfwiodrekncheisitnotreyr:vaolnolyf gfeilomm,etDr-i1c Mmaekaenrfor or film with prior chemical work history Only Film" D-1 Maker" Film with previous history in chemical -- O N=35) NN==6O 69) = NN==118y) 0.122 0032-0250 0.367 0.122-0.946 0212 0.080-0.692 9G.5%MeCaLn. 0.009.01.110%29 0.15092-809."527 0.178" 0137-0233 PFHS Mean Range 0015 0.001-0075 0.023 0.005 -0.030 0.038 0007-0210 G. Mean 95% C1. 0.010 0.008-0.014 0.020 0.011-0.034 0.023 0015-0036 POAA Mean Range 0.052 0.006-0.298 0.122 0.020-0.197 0.090 0012-0246 G. Mean 95% C1. 0.037> 0.028-0.049 0.093* 0.044-0.19 0.067" 0.044-0.100 PFOSAA Mean Range G. Mean 95% C1. 0.003 0.001 -0.009 0.002 0.002-0.003 0.006 0.001-0.022 0.004 0.022-0.009 0.005 0.001 -0.038 0.003 0.002-0.005 M570 Mean Range G. Mean 95% CL. M36 Mean Range 0.022 0.0008 - 0.454 0.007 0005-0010 0.022 0.0001 -0307 0.018 0.0021 -0.083 0010 0.006-0.017 0.005 0.001-0.014 0.018 0.0014 0.069 0.010 0.004 -0.026 All values <LOQ G. Mean _--95% C.I 0.003 0.001 0.006 0.003 0.002-0.004 (a-<) comparison for each current job category using student's, p<.0s ~~ 001357 aM EPaPgLe-07090o6f 85 Table 27. sRuabtsieotosf:felmuporloocyheeemsiocnallylweivtehlsfbilymrpalnandtomexpsearmipelnecoef; feimlpmloeymepelsoykeneoswinnctlouhdainvge worked on D-1" Maker;and employees with prior chemical history Only Film N=36) D-1 Maker N=6) Film With Previous History In Chemical N=18) PFOS/PFHS Mean Median Range 149 104 18-1076 18.8 12.7 50-466 93 74 33-320 PFOS/POAA Mean Median Range 33 28 07-92 57 24 09-210 32 23 12-101 PFOS/Analytes Mean Median Range 100 78 02-376 256 1s 21-918 126 103 30-407 PFOSAAMSS6 Mean Median Range 19 1.0 0003-140 28 13 03-109 21 12 04-151 MS70/M556 Mean Median 50 69 23 34 7.1 45 Range 03-450 08-282 06-276 _--Pm------ 001358 Table 28. 3EPMI-0006 Page 80of85 cDaetmeogogrriaepshwihcochhaarvacetewroirstkiecdsoofnrlyanidn othmesfaimlmplpelaonft f(ii.lem.,pnloatntonemtphleoDy-e1esMbaykecrurorrenptrjioorb work in chemical) Age Mean SE Median Range BMI Mean SE Median Range Years worked In film Mean SE Median Range Gender Female Male Hand to mouth Contact Yes No Wash hands Yes --fNoo Engineer/Lab -- (N=10) -- 46 28 4 23-58 2638 15 213 216-317 148 29 1s 01-29 2 Qo 8 (80) 8 G0) 2 Qo) 8 80) 22 QQoO Film Processor N=12) 4" 25 47 27-59 286 14 278 180-418 14.1 26 17 05-29 2 an 0 ) 108) 2 an 10 83) 22aomn Maintenance N=7) 40 33 40 31-51 287 18 295 241-329 Administrative -- N=7) -- 48 33 50 40-55 202 13 27.9 244-418 46 34 3 05-12 [) 7 (100) 204 34 25 5-28 2) 5a 46 3 @) 6 (36) 11a4y 46 3@ 4 67 33 @@)) 001359 `Table 29. EMPmL000G Page 81 of 85 sMeeraunm, frlaunoger,ocgheeommiectarliscfmoreraannadnodm9s5am%pcloenoffideemnpcleoyineteesrvawlhoofhgaevoemeotnrliycwmoeraknedof in the film plant (i.., not on the D-1 Maker or prior work in chemical) PFOS Mean Range Engineer/Lab -(N=10) 0.097 0.055-0.140 Film Processor" N=12) 0.127 0032-0250 Maintenance N=7) 0.159 0137-0216 G. Mean 9S%CL 0.093 0074-0.116 0.106 0.074-0.154 0.157 0.139-0.177 PFHS Mean Range 0.016 0.001-0.075 0.015 0.004-0.047 0.016 0.001-0.034 G. Mean 0.009 95%CL 0005-0018 0011 0.007-0.017 0011 0.005-0.026 POAA Mean Range 0.030 0.006005 0.055 0.007-0.154 0.098 0.021-0.298 G. Mean 0.022 95%CL 0014-0036 0.041 0.024-0.068 0071 0.038-0.132 PFOSAA Mean Range 0.002 0.001-0.005 0.002 0.001 -0.009 0.002 0.001-0.006 G. Mean 0.002 95% CI 0.001-0.003 0.002 0.001 -0.003 0.002 0.001-0.003 M570 Mean Range 0.006 0002-0017 0.048 0.003 -0.454 0.018 0.006-0.046 G. Mean 95%CL 0.005 0004-0007 0.010 0.004 -0.022 0.014% 0.009-0.024 M36 Mean Range 0.002 00001-0003 0.029 0.003 -0307 0.005 0.001-0.016 G9.5%MeCaLn 0.0001.-000.1003 0.0002.-000.50"11 0.0002.-000.4007 em (ad) comparisons for each currentjob category using student's t Administrative? N=7) ol 0.054-0.166 0.104 0077-0140 0.012 0.006-0033 0.010 0.006-0.016 0.039 0017-0063 0.035 0.024-0.051 0.004 0.001 -0.006 0.004 0.002-0.006 0.005 0.001 -0.009 0.004 0.002-0.007 0.002 0.001-0003 0.002 0.e00e2-0.003 001360 3M EPaPgLe-08020o6f 85 Table 30. Ratiooffluorochemical levels by employees who only have worked currentjob among in film and not on random the D-1 sampleof Maker film PFOS/PFHS Mean Median Range Engineer/Lab --EN=1100) 13.0 75 18-616 Film Processor ~~ Maintenance ~~ Administrative NTMN==12)) NTMN==7) NN==77) 130 28 49-290 2.6 122 43-1076 1.1 104 51-165 PFOS/POAA Mean Median Range 40 30 13-92 32 32 12-63 27 21 07-67 30 28 22-42 PFOS/Analytes Mean Median Range 104 105 21-178 100 43 02-312 7.1 70 40-116 124 9.5 52-376 PFOSAA/MSS6 Mean Median Range 36 11 05-140 07 0.5 0003-15 13 05 01-61 2.1 23 05-44 MS70/M556 Mean Median Range -_-- 86 25 10-450 31 16 06-184 56 59 04-105 26 28 03-55 001361 Table 31. 3EPML000G Page 83 of 85 Demographic D-1 Maker or characteristics ofall film plant participants (N film plant with previous history in chemical = 76) by only film plant, Age Mean MeSdEian Range All (N=176) 45 471.0 23-59 Only Film (N=49) 44 43.6 23-59 D-1 Maker N=7) 44 47 12 30-55 Film w/ history of chemical i (N=20) 47 512.1 28-58 BMI Mean SE Median Range 283 0.5 279 18.0-41.8 285 0.6 279 18.0-41.8 26.6 15 265 217-317 285 10 28.0 20.0-37.9 Years worked In film Mean SE Median Range Gender Female Male 144 12 16.0 0.1-36.0 16 (21) 60 (79) 152 14 17.0 0.1-30 8 (16) 41 (84) 81 35 20 1-21 2 29) 5 (7) 146 25 15.0 1-36 6 (30) 14 (70) Current job Engineer/Lab Film processor Maintenance Administrative Longest job EnFgiilnmeperro/ceLsasbor Maintenance Administrative 18 (24) 34 (45) 11 (14) 13 (an 3184 ((5108)) 12 (16) 12 (16) 12 5) 20 (1) 8 (16) 9 (18) 28 @(1)6) 9 (18) 8 (16) 0 (0) 6 (86) 1 (14) 0 () 60 (86)) 1 (14) 0 (0) 6 (30) 8 (40) 2 (10) 4 0) 68 ((300)) 2 (10) 4 (20) cHoanntadctto mouth Yes No `Wash hands Yes No 49 (64) 27 (36) 65 (86) 1 (14) 36 (73) 13 @n 40 (82) 9 18) 51 2 29) 8 (40) 12 (60) 7 (100) 18 (90) 0 (0) 2 (10) 001362-------- Table 32. PFOS Mean Range Mm EPaPgLe008406of85 Mfleuaonr,ocrhaenmgiec,aglseofmoertarlilcfmilemapnlaanntdp9ar5ti%cicpoannftiedmenpcleoyienteesrvbaylowfogrekomheisttroiryc: meanofserum only film plant, D-1 Maker or film plant with previous history in chemical Only Film* (N=49) =0.129 -- 0032-0264 D-I Maker" -- N=7) -- 0347 0.122-0946 Film with previous history in chemical -- N=20) 0220 0.080-0.692 9G.5%MCeLaLn PFHS Mean Range G. Mean 95%CLL POAA Mean Range 0.1010-.01.1163"3 0.016 0.001-0.075 0011 0.009-0.014 0.057 0.006-0.298 0.1680-207.94"61 0.022 0.005 -0.030 0019 0012-0030 0.146 0020-0290 01440-.108253* 8 0.038 0.007-0210 0.024" 0.016-0.036 0.146 0012-1220 9G.5%MeCa1n. PFOSAA Mean Range G. Mean 95% Cl. M570 Mean Range G. Mean 95% CL. M556 Mean Range G. Mean -_--95% C.I 0.0301.-0040051 0.003 0.001-0.020 0.004 0.002-0.003 0.018 0.001 0.454 0.007 0.005 -0.009 0.009 0.0001 -0.307 0.003 0.002-0.004 00540-.010292"1 0.006 0.001 -0.022 0.004 0.002-0.009 0.039 0.002-0.164 0015 0.005 0.046 0.006 0.001-0.015 0.004 0.002-0.008 0.0490-.007.81"24 0.006 0.001-0.038 0.003 0.002-0.005 0.017 0.001 -0.069 0.010 0.006-0.016 All values <LOQ (a-c) comparison for each current job category using student's t, p <.05 001363 aM EPaPgLe00850Gof85 `Table 33. Mfleuaonr,ocrhaenmgiec,aglesofmoertarlilcfimlemapnlaanntdp9ar5ti%cicpoannftiedmepncleoyienteesrvwahloofogneloymweotrrkicedmeinanfiolfm splearnutm (ie., not on the D-1 Maker or worked previously in chemical) PFOS Mean Range Engineer/Lab TMN=12) -- - 0.108 0.055-0.170 Film Processor" N=20) -- 0.133 0032-0264 Maintenance N=8) -- 0.168 0137-0237 Administrative' N=-- 9) 0.108 0.054-0.166 G. Mean 95% C1. PFHS Mean Range G. Mean 95% C1. POAA Mean Range G. Mean 95% CLL PFOSAA Mean Range G. Mean 95% CL. Ms70 Mean Range G. Mean 95% C.L Mss6 Mean Range 0.102 0.082-0.127 0018 0.001-0.075 0.011 0.006-0.012 0.049 0.006-0.188 0.0316 0017-0054 0.002 0.001 -0.005 0.002 0.001-0.003 0.006 0.002-0.017 0.005 0.003 -0.007 0.002 00001-0007 0.114 0.080.148 0.016 0.004-0.052 0.012 0.009-0017 0.05 0.007-0.154 0.040 0.027-0.060 0.005 0.001 -0.020 0.003 0.002-0.005 0.031 0002-0454 0.008 0.005-0.013 0.019 0.001 -0307 0.165% 0.143-0.191 0.016 0.001 -0.034 0.011 0.006-0.023 0.095 0.021-0298 0.072 0.042-0.124 0.004 0.001-0.017 0.002 0.001-0.005 0.017 0.006 -0.046 0.014 0.009-0.022 0.005 0.001-0.016 0.103 0.081-0.129 0012 0.006-0.033 0010 0.007-0.015 0.037 0.017-0.063 0.033 0.025 -0.046 0.004 0.001 -0.006 0.003 0.002-0.005 0.005 0.001-0.009 0.004 0.002-0.006 0.003 0.001 -0.006 : r eG9.e5%MeCa1n. -- r0m.0010.-000.100-- 3 0.0002.-00-- 04."006 meee 0.0-- s0020-1r04.007rae r 0.0002.-000.2003 (ac) comparisons for each current job category using student's t, p <.05 001364 AppendiAx Decatur Plant Maps APapgpeend1ix A 001365 5M DecatRuresAleab1a6ma9P7lant Layout a ad a ml Br AE EigD en] DeSnm BE| Sl Ea = | |D aaad No 5"B8E:"| BInnEn, 077=9 Ee E mrv p EE=oR lo Q iopREo]|.= \ | i(Er Ed a=t 2) i " 3 BE CiYg & ~ re 4 ww He! L/h. wa) Le i 3M Decatur Chemical Plant oT i) Loi "-- TTT -- = HBE] aFe]get= oe 8 ; a oF - ON 3 ue = rr i@ Ea ; BF ~ [ee] Dyneon % i Appendix B Study Questionnaire APapgpeend1ix B 001368 DECATUR EMPLOYEE QUESTIONNAIRE APapgpeend2ix B a`Tnhankinyotuheoarpppraorptriciiaptaetibnogx.in this research study. Please respond to each question with either a short answer or NAVE. 1. Have youeverworked in the Chemical Plant? 1f ng, please goto question 2 EMPLOYEE NUMBER, Yes O No O if yes' a. How many years haveyou worked inthe chemical plant? Years=_______ b. Whatyeardid you start working in the chemical plant? Yea=r 2. Please indicateifyou have ever. workedinthe following areas. Mark an in all boxes thatapplyto you. O suiding 1 0 Buildings 2 andlor 49 0 Building 3 (OSCLIOSF ares) C1 Building 3 (besides OSCLIOSF area) O sidin4g North 0 uiking 4 milloomvextruder O suing 17 O Buildings 38 and/or 51 0 Building42 (Packaging FG inerts) 0 suiding 61 [J] Film Plant al buiklings) 1 Wast(euwialtdeirngtsr3e6atamnednt5p7l)ant 0 POtlheearse specify) _ 3. `Tahnisnwkeirngthaebofoultlotwhienjgoqbutehsattioynos.u workedfo thelonpegrioedosftitme while employed at 3M Decatur, please a Jabiite; b. When did you work there: From (_ year to, (year) Average number of hours per week on this job? Hours = 4 When you worked overtime, what was your usual ob assignment? 4. Please answer thefollowing questions regardingyour currentjob Current plant: Chemical Fim 0 Curent ob tte What year did you start working in this current job: Year = oer 0 001369 APpapgeend3ix B `Average number of hours per week on this job: Hour=s When you work overtime, whatis your usual job assignment? 5. Please indicate in which area(s) you woriknyour current job. Mark an * in all bothxataepplysto you. 0 suidin1g 0 Buildings 38 andlo5r1 0 Buidings 2 andlor 49. 0 Bui3d(OiSCUnOSgF area) 0 Building 42 (Packaging FC inerls) 0 suiding s1 0 Buiding 3 (besides OSCLIOSF area) [J Fim Plant al buiklings) 0 Buiding 4 North 0 Bi4kmillioomyn extrg uder O suiting 17 [0 Was(tBeuwialtdienrgstr3o6atamnednt57p)lant 0 other Clessospeaty 6. While at work, do youchew gum? O aways [OJ frequently [J sometimes (J rarely [J never 7. While at work, do you chew tobacco? O a aways OJ requenty [J sometimes (J rarely [J never 8. While at work, do you smoke cigarettes? Oavays O frequenty [J sometimes [J rarely [J never 9. How frequently do you wash your hands before eating while at work? Markonly one box. O aways OJ frequently [J sometimes [J rarely [J never 10. What is yourheight? 11. Whatisyourweight Feet= Inche=s Pound=s 001370 PAapgpeend1ix Appendix C DistrAimbuotniognCohfeFmliucoarlocEhmepmliocaylesesa(nNd T=he1i2r6)NaintutrhaelRLaongdTormanSsafmoprlmeation 001374 CRhaenmdiocmalSPalmapnlto PEOSpom W 3 5TEfi _| maximum Qu1a0n0t.i0o%s 10.600 9997.55%% 10.600 7.187 quirile 200% 75.0% 3132 1.925 median 500% quartile 25.0% 1.140 0.440 100% 25% 00120125 minimum 05% 00% 0091 0091 Mean Moments. StdDev USptpdeErr9ro5r%MeMaenan NLower 95% Mean Sum Weights 11.65102427 01..17483960 1.2204 1260000 126.0000 `S`hTaopsitfroo-rWNiolrkmWaliTteyst 073439W9o P0r0o0b0e0w APpapgeend2ix C 001372 ACemrnenraa, i IfmE |] ]|: 1 j win [wsS--Hrn.R u2n3e0e0 wie n BE mebo wRoaB FhwAE eaoinae wn 008 2006 YEiinfn ons oftureso fSreenatsNs osSoemamo BTeoookommiaes nro"noaat AppendiCx Page 3 001373 FGahnPodmFioScmalSpaPpmlmpanlte TM wgJ ". L=i | musi Qu1a0nt0t0o%s 995% 1188850000 qui 90705%% 750% o17s36m5 04200 mqeduiaen 525000%% 00017780s0 21500%% 0000313347 minimum 0005%% 0000005ss Mean Moments SiDev o0a3i4r570 USptdpEerrr9o5r%MeMaenan 0004316776 LoNwer 955% Mean 1206.20702040 Sum Weights 126.0000 ShTaopsitrooWriNokrmWatTyest 072990W6 P0a03s0a0 APpapgeend4ix 001374 RCahnodmoicmalSaPmlpanlte In PFHS ppm T JE JI ia 4i a 7} | . maximum Qu1a0n0t.i0o%s 013 9979.55%5% 0056830123 quite 7250.00%% 01307 "08675 median 50.0% 17720 quite 215000%% 23.54406017 0255%% 43022 52269 minimum 0.0% 52269 Mean Moments SSttdd EDrervor Mean LUopwpeerr 9955%% MMeeaann NSum Weights ams 01.21202859 11.94390976 112266.00000000 ShTaepsitrofo-rWiNlokrmWalTleyst 097528W3 P0r2o3b0e2 APapgpeend5ix C 001375 ChRoaPnmdiOocAmaSlapPpmlpalne Bl] : 7 31fle i, "he _- [ ) maximum Qu1a0nt0i0o%s 6760 9979.355%% 6S7e6s0s qurile 01500%% median 500% 23.04732050 13000 que 120500%% 0013288610 2055%% 000021048 minimum 00% 00208 Mean Moments Std Dev 1153336539 USipdpeErrr9o5r%MeMaenan Lower 955 Mean 0117171580 13007 NSum Weights 11226600000000 ShToastpoirrNoo-mWaiiTtelyskt 087536W6o P<r0o0b1e APpapgeen6dix 001376 RCarnhdooaSsmulmsaapn Ja |. 4 i] +1f8 5} JJ .. maximum Qu1a0n0ie%s 05% 1139111100 7050%% 1127331080 qmeduiaen 7S0500%% 0072268284 que 120500%% 220553510 2a5s%n rSeayo minimum 00% Sacto Mean Moments Sev 011205641s SUippEerr9r5M%eaenan oauitsst Loxver 95% Mean Sum Weighs 12p60r000 1260000 ShTaopsitrooWriNkorWmTaat ososWy ab<aomnl AppendiCx Pag7e 001377vo RCahnodmiocmalSaPmlapnlte PFOSAA ppm w . us . w 3 wg & on se maximum Qu1a0n0t.i0e%s 026900 9979..55%% 001246991050 qurile 9750.00%% 000062383112 qmuerdiialne 2550.00%% 000000820786 21500%% 000000111122 minimum 0005%% 000000111122 Mean Moments SStdd DErervor Mean LUopwpeerr9955%% MMeeaann NSum Weights 000000023339536 0000310633 112266..00000000 ShaTpoisrtof-orWiNlokrmWaliTteyst 060078W9o P0r.0o00b0 APpapgeend8ix C 001378 RCahnomdiocmalSaPmlpalnet. In PFOSAR ppm 1s BE 42 a : maximum Qu1a0n0t.i0o%s "13130 997.55%% ""1193018350 quale 970500%% 23577610219 mqeudailaen 5250.00%% 4588198146 21500%% 6677994444 minimum 00.50%% 6677994444 Mean Moments SSttdd EDrervor Mean ULpopweerr 9955%% MMeeaann NSum Weights 4L7a8s1932 40..5132000 1256..00308060 126.0000 `SThoasptirfoo-rWNilokmWnalTeyst 092952W7o P<r0o0b0a1w APpapgeend9ix 001379 ChRaenmSdi7ocm0aSlaPmlpoaprnlse , 5 . u . : w5gi 3 ug EE " L maximam Gu1a0nt0ie%s 099200 997953%% 006999210003 qurile 07500%% median 500% 001491652750 0068s que 215000%% 000032717733 2053%% 000000894605 minimum 00% 000840 Moments MSSetdaaDnneovrMean Upper 955Mean 00o.0111s5e602s5 01833 Lower 955%Mean 01176 NSum Weights 112266.00000000 ShTaopsitrooWriNlokmaWitTeyst 071285W3o P0r0o0b0a0w Appendix Page 10 001380 RCpahenmroieSyaprango Lig = a li] [i mmm Qwulasornhtgs 0o00o80 que S0o5o8%n Soa5es70ws0 eadlne 33T0o00o%%r SSS0oo5m minimum G02505%% pLprrr Womens Mean 25145 LSSiUitnddepeDrnreovs5r.5s%M%eacneann 2ip151tr11e7d6d67 SxumWeighs f26i0r0e0d0 ShTaoptrtooriNoWrWmatTyeBonen assis "oor AppendiCx Page 11 001388% `CRhaonmdiocmalSaPmlapnlto PFOSA pp 5 . os . 0 i) - - 5 ol maximum quale mqeudaiialn minimum Qu1a0n0t.i0e%s 9979.55%% 970500%% 520500%% 100% 0255%% 0.0% 006611220000 0.47948 000253612850 00.0010129659 000000015202 00..0000005500 Mean Moments Std Dev SUtpdpeErrr9or5%MeMaenan LNower 95% Mean Sum Weights 00.01611685 00104 00.00842132 126.0000 1260000 ShTaopsitrofo-rWNiolrkmWaliTteyst 056092W9o P0r.o00b0e0 APpapgeen1d2ix 001382 SCpaharmcav opmana ; a;2 iEE I=E | | = N mmm cmlusoeeos o01w0 oe aoSoosnn aadnemy Ghanne 3soo0oxnn dsaamsm minim s0250a% oTSooaoorr vSeer aman a3s0siiso JSUrippiEsr0rb5%teoaennatn Sioosirseey SuN mWeighs 123600000000 PTotcoNiomWaeoo asi ooo AppendiCx Page 13 001383 RCanhdoo3mmaaSouplmralnto wo . : " , wg : ws 4 wl oT w L meinen C5u1s0%t0o%s o04u06s00 quriie 07s500n%% 00oo15s51s06n0ss0 nfaelde 35l5o00o0%s% a0d0o0a03rs1s05s0 minimum 200550%%% 00000104s0 aii SMeuaeny Moments 0oa0si3s LUopSvpdeenrro99e55M%%eMMaenaann 00000005ssi NSum Weighs 11226600000000 ShTaopsitroorWNiokrmWaliTteytProva oss "000 APpapgeend1i4x C 001384 eCisresanem ii 3 aiE) [ J F I a4 masini I w00s% a aso wie on 00i8 m aaee w--n hoooxar adaimeo minimum roG0eo8 o"poimmd jSoer Vora 36Boer sn aofiinst LoxCovveero555k%ienn 13pS60i50t050 -- eon S [e -- A anan osartt eons Hes AppendiCx 001385 APpapgeend1ix D Appendix D DistrAimbuotniogn FoiflFmluPloarnotchEemmpilcoayleseasn(dNTh=ei6r0)NaitnutrhaelRLaongdTormanSsafmoprlmaetion 001386 RanidmompSiamnple proesm "" . " w= ffe : a[ ; maxim PPnCosnwon o09b40i0 que aS70o3%x oo0amm0mees wheaiem smoooonvr ooootneme minimum a05s0s% QGGoooissr0 SViebner Womens SirenMen aGGoilmiooss jNUprpeerod5e5i%dNoannd 0p00i20e00d% SomWeighs Goo Sh-- ape WH hn oon oo eos AppendiDx 001387 RLaFnnidPomrmPOlSSaanomopmle wwp 5 ng 15 by. 35 F o rr maim Qu0a0n0to%s 95% 000s5s5ss qurie 0775050%%% "A22as1s9me7 umerdiain 520500%% 100% 22`7o40s01t2 minimum 0255%% 00% Lsooles Zion SMiedaDnev Moments 5a9a6r2on2 SUirdpeErno9n5%MeMaenan Lover 95% Mean 8P002r80a778t8 SNum Weighs 00000000000 StTaosptrfoorWNorWWmatTtiytProny or ods APpapgeend3ix D 001388 RanFdilommPSlaanmtple PFHS ppm wn wm b : [CR | i w maximom mqueadritialne quire minimum Qu1a0n0t.i0e%s 9979..55%% 9750.00%% 2550.00%% 2150%0% 00.50%% 002211000000 00..0144666700 00002161690 000718 00.0000153615 00.0000113311 Mean Moments SSttdd EDrervor Mean LUopwpeerr9955%% MMeeaann SNum Weights 002258 000003309573 003053 5090.10406020 59.0000 ShTaepsitrofo-rWiNlokrmWaliTteyst 057807W9o P0r.o0b0e0w0 APpapgeend4ix D 001389 . RaUFnnidPomFm SSpaanm5tpp le ; 1 shi am ISE fi = a:4b I o maximum Qu1a00n0t%o "15606 997955%% 2"L0eo8s mqeduiain 725000%% 500% e30266682 San que 120300%% S"3e6ls 2o5s%% minimum 00% sperm Sem Mean Moments StDev 402965728500 USpipdeErro9r5M%eMaenan o0l1o2s0s1 LoNwer95% Mean 5i5.s00i00n0 SumWeights 59.0000 SThalooWrpiNlsokimWatrtTyoost oss:W Porosbasr PAapgpeen5dix D 001390 RanFdiommSpaarmtple TM 3 wg i 1 JB a [ w N maim Qu1a0ni0o%s 029800 9955%% 002257820000 qmeduiaen 07500%% 500% 00.1105840000 00ss20 que 215000%% 000012546000 minimum 2055%% 00% 00000056s018 000598 Mean Moments 007084 SSUtippEDererv9r5%MeMaenan 000006820070 008700 LoNver 95% Mean Sum Weighs 509000500i0 59.0000 SThafooWrpNIsoimattrTteyot ose%Ws ab<a00n01 APapgpee6ndix 001391 R(Fan1idPmoOmPSlAaamnBpptle wp 20 EE 3 ET ent 35 "mg 1; 15 E Es 5 5 maximum Qu1a0n0t.i0e%s 12107 99795.5%% 2"11300675 qurile 795000%% "2r2s27058 qmeudiaen 520500%% m289968 21500%% 6so037s7 minimum 0050%% S1119933 Mean Moments SSideErvror Mean LoUpwpeerr 9955%%MMeeaann SNumWeights 300921039375 20718129915 5392.50809090 5900000 ShTaopisrtofoWriNokmWaiTteyst og1s2W3o p0r5o1b2a2w Appendix D Page 7 001392 RPaFRniGdomSmApSlaapmnotpmle om ws ws ws oe : ws wg ww tc maim Qu0a0n0t%o 00s 9595%% 00% r000e7s 000635 qmeduiaen nile 570500%% 250% 0000004807 oii 2f5ir%s 05% rrea 000112 minimum 00% ooo Moments SMSeuaaEbnerro Mean Upper55%Mean 00G.0o00s003s79a27 precy Lower95%Mean 0002s N-- 5559..00000000 ShTapoisrtofoWNiorkmWattTiys osuesWs P0r0o0b0 APpapgee8ndiDx 001393 LnRPaFnFidOmoSmPSAlaaAmnptpplmo 3 5 " 1 55 ETE 3 5s 13 _ maximum Qu1a0nt0i0o%s 2754 999735%% Ssamss que 07500%% median 500% 5S032973 Sms qurile 215000%% "`5e7799444 0235%% ""6617090%4 minimum 00% "67044 Mean Moments 5958s SStidd DEemvorMean Upper55% Mean 008141707575 573751 LoNwer95% Mean Sum Weights 5691070903060 5900000 ShToastpfiorrNoo-mWaWliTtelysk osW P<oobol APpapgeen9dix D 001394 RaFniSd7om0mbSpalpamnple " b i on |. mesimam Qu1a0n0ie%s 595% 00.4455440000 qurie so0r05%% 750% 000245s109s3 00120 umerdiain 152005000%%% 00000000026359210 0255%% minimum 00% 000000101820 000080 Mean Moments SidDev 00005290014 USpipdeErro9r5M%eMaenan Lover 95%Mean 00000736s2 000199 SNum Weighs "6000000000000 ShTaosptifooWriNokmaWttTeyst 0200W9o P000b00 AppendiDx Page 10 001395 ran A: J mm | a7i win amCvoeEer aanne nuee BR0omr29a8me nn 03 0 amen mYSA eeen,rmeeenn dSa iainem 3Yves paemcet BTeoosrieimttseTyraSoR fps AppendiDx 001396 RaFnidlommPSlaamntple M556 ppm os w 3 us m us on S-- maximum qmueidniialne quinile minimum Qu1a0n0t.i0e%s 9979..55%% 2705.00%% 2550..00%% 100% 0255%% 0.0% 003300770000 00..1005549037 000250 000000225500 00.0000101217 000010 000010 Mean Moments SStiddEDrervor Mean LUopwpeerr 9955%% MMeeaann NSum Weights 0.00816 000003590382 000001280302 6600.0000000000 `STheasptirfoo-rWNiolrkmWaliTteyst 016226W6o P0r.o00b0e0 APpapgeen1d2ixD 001397 RanFdilommPSlaanmtple Ln M56 pp TF 3 Ffr-- a + . + . in maximum Qu1a0n0t.i0e%s 11809 99.5% 975% "217.4181089 quire 2750.00%% 55.91921854 qmueidniialne 500% 250% 59915 59915 102.50%% 6876633326 minimum 00.50%% 9922110033 Mean Moments Std Dev SUtpdpeErrr9or5%MeMaenan Lover N 95% Mean Sum Weights 509935079972 0.12367 56.6187385412 6600.0000000000 ShTaapsitrofo-rWiNlokmaWltTyest 068287W4 P<r0o0b0e1 APapgpeend1i3x D 001398 APpapgeend1ix Sc(aYttReSrpClHotEsMa)ndforregrreasnsdioonmesqaumaptlieon(snf=or1f2l6u)oaroncdhefomriccaulrsrebnyt jyoebarcsatweoorgrkieeds i(ncchhemeimciaclal operators, engineer/lab, maintenance, supervisor/mgmt and mill operators) 001399 Th PFOSRpanpdmoBmySaYmRpSlCeHEM ns w fo Em patio " Somn 8ws s wa PAapgpeen2 diEx SoMuordecle EnCeTrou InTeormeept YRSCHEM PFO=0SS.Lu8i9nm1de7ma8ra+o0Fiirf.tF0y4t7p8 YRpSCHmEM RSRqquuuarree Adj 0.01.0100888078 MReoaont MoefaRnesSpqounasree Ector Observations (orSumWets) 11550248678566 126 oF1 A"nSuancloifSyVqasuraiimanssce 3511712 MesnSSqIuaTre 1r5.a0t06o0 121s4 228499719697664 233 P00w00r2 OSEsOiImTslEe 0P2oS0rW8aE6mm8e2rerEstiRma4at2le7s Pr<oO0b0l0]l 007029 0032 388 00 LOoAwTeErEdSST% 0023363 1Up3po0roiss 00n2ile 001400 aio aro Page 3 one En E tn oo sar uid sS01ia e oooro ns vem scrEoJ m z A ene t we ooizgee soshes m orEee CLsUtRe SvEorSes rn Tim come was Bam sem faTSolml Cochfooftmse wSEugmmo'iTnn SsEiaatls eomatNn rmolomnwmns Ucurmhpumio 001401 POARanppdmom8,SaYnAgSlGeHEM 5 : sw -. . go Lo ESwL LLL [ET Te en -WET el . rel+ Sn wEowa sw PApapgee4ndix SEMoomudrercle Coal YInTRtoeSmrCceHpEt M POAApP= LSu2Umn5oma43rao0ifr0t51Fyi899 YRSCHEM RRSsRqoquoutarrMeeeaAndSquare Eror 0103012640763s34 OMbesaenrvoaftRioensspoonrsSeum Wet 1536217216 or| AMneaomfSVioaiorrisiasonce MemSSwime Furimo 11254 n213765s772848 175466 P0r0o7b9a4r 1Es9mu%o OPaSBruaEEmemStrerEtmRat7ao1os6 P<uobmll L0ow9er%s ole 0010885 177 ooms oom UTopepsioesrbnoess 001402 Ww PEOSRAaAndppommSBaymYpRlSeCHEM w Z3 w C - h -- E eeS n r SS wnwonms naw Aopendi&x Page 5 PFOS=SA0.u0nm3aA2am1r5aoF-dfru0F.yt0f0069pYRpSCHmEM RRSsqquuaireeAd RootMeanSquareEr oa0s03i7s3 003898 OMbesearnvoatfiRoensspo(norsSeum Wet 002322963 NSooduers or| AMsSsmoooSouvamromasnco Mem0s0w0amn aFrsuioo EnCloorut 112s4 O01I9B57H09O3E6 0O0ISIS P0r0o0b3e TIonemreept YRSCHEM 0E0oi2maie oPaSorGamEmemterEstPmaa6tl0oo4s P<ro0bl Loowoerdmst eUpponrdsw 0006 000M 219 00303 00013 Doone 001403 srasconRSarSgleE ww d w"i - Bef -L HITwE f So "re .. w J rEE er Ta E 5d AppendiEx NSTmpm= S1a7J 1m0a0n2F2at3 YRSCHEM RRoRosgqsuureeenagSqr Ee NefRepos Gcoooluremrrneisss Gist Ctveaion oxSum Wis) fi EfSrorueeee Chow m orTo Ad EnaRTloe fiyVascOriikansce we"atsooewss mies pFSeoitme ive TnRoeemceh CEoosfmmSe doSPaoiorraeaanarCtitR7dem0sseamPooobmill GGlrooowsrwsssn aCUphcpmeooown 001404 ww prosxpoRmbayndo SamVpRlBeGHEM wl . 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" " TE e wm ne a e ane t nA wou Page7 AppendiEx PFO=SS00uA6Um73nm1daoo0rfF0ty0t04p3YRpSCHmEM RoRRqoouwMueaeAndSquareError Oo"mo1ioeer6sss NOihcaenrovttReosnpoonrsSeum Wi) Qosir2o6n VSEooutrrece 1o4F| AMniamlOoGofoyoVatassmriisiaaznesce Mem"oC0Soiwoewseeas PoFrarasnto Coal 135 Lo Senn YTRormSeCnHtEM 0E0w0a6 OPSDaurIatsmesetrserEsiRma4at3els3 P<obm LoGwrodsswn Uopppaearsoessw 00003 000093 04s oa oom omiea: 001405 w M555RappnmdomBySaVmRpSlCeHEM wo, - PAapgpeen8diEx Fog, . v.. = weuv tfJ : + JE EpA r AEACe EC EA wa SMooudrecle ErCrooar l Totemreept YRSCHEM MSS=06 S.L0ui59nmd5em3ar-ao0Fi i.frt0Fy0i0tp59 YRpSCHmEM RsRqquuuurreeAg 000.000901088 ROMobesoaetnrvoMafetRaieonnsSspquo(anorrseeSEurmrWoret) 00005713974116 126 OF1 A"Snum0o0soi0fS5Vq5auy7ra7ir7aesn6sce Mea0n0S0q5u3a7r8e r0a9t8o% 11s4 006677358220978117 0008638 P0r3o2b1o8r 0E0w9im5s2e 0P0SarU1aE0mM0eot6rerEsti(mFa5tael%se Pr<0o0b0lI L0o0w3e0r6s0s8% 000052 000055 099 03218 000176 0U0pp7o4rdss 00005854 001406 PGEhGaFSmaipncodamolmBOySpaYamrRpsSloCerHsEM mn m : in sw . $e . Em ee w --_-- wee EAE wCoRE REAL BE PAapgpee9ndiEx SMooudrecle [Caoal TIotmrcept YRSCHEM PROSGipp=m 1SLui.mnema+ra4Fo0irf0tF3y1t3126YRS4CH6EM RRSSqquuirreeAd Root Mean SquareEon 00003650640886 1237904 OMbesaenrovfaRieonssp(oonrsSeum Wt) 17811a06 ofi ASnuamoloifSyVqasurimiasnsce 4439524 MeswnSaauere 2Fr6amio a%s 6783935987289270 15241 P0r0o9b5a6r LAEGsItSaSsL PaSrWamEemterr 02081 Etm(aFtaelse 506 P<u0b0l0li LoOswsearusass%s OBIE 0019957 170 00956 000607 Ulpapeewrmoesr ores 001407 ChReamnicdaolmOSpaermaptloers wm PHS ppm By YRSCHEM APapgpeend1i0x E ee :w| Le] Pos ons mos nox wo MSooudrecle ECrTmoorul InTtoermcept YRSCHEM 'PFHSdip=p0m.1L4i8n1e3ar+0Fi.t0254YRSCHEM RSquare Summary of Fit 0342256 RSquare Adj Root Mean SquareError 0.32764 0333897 `MOebasenrovfatRieosnpso(norseSum Wis) 0427751 a OF AnSaluymsiosloSfqVuaraieasnce MoanSquare 1 4s 26105644 50169158 261056 01149 46 76274602 23F.R4a1t5i7o ProbsF <0001 0E1s4t8im1a2t9e 00253956 SPaWrEammoetrer Est(imRaateos Prob 007573 0005248 19 00562 484 <000l 0L0ow0e4r0d8s2% OOM48254 0U.p0p0e3r39955% 00359659 001408 PORGRhAaapmonimdcoalmBSOypaYemrAapStloOerHsEM Tw : on - su IB) : , | 2 wf wT . w S 8an sas woo PaAgpepe1n1diEx SMaoudreclo EmCoorl InTeormcept YRSCHEM POAAPP= 173n3e8+a7r0F.it04702YRSCHEM RSquire SummaofrFyit RSquareAdj 0000799933576 RMoeoatnMoefRaensSpqounasree ror 21235412557048 Observations(or Sum Wats) a oF1 A"aSusmooiifSVqyauraiimasnsca 894563) Me5m9S4a8e6 F49r6i5o0 a%s 981010054379630 150233 P0r0o3b0e9 LE7si3ma6to ParSadmEemtoerr Esti(mRataeso 03067 571 P<roo0boll Lowie2rS1s8% 000188 0G2Il0l 223 00X9 0064SIET 2U3p6p5er8o6s8k 0omSIS 001409 ChReamnicdaolmOSpaemraptloers PFOSAA ppm By YRSCHEM we APpapgeend1i2x E -1) t= Cosom woo sWs K ws Source Model CErmToorul InTtoermcept YRSCHEM PFOSAAdfppm =0L.i0ne4a9r4Fi0t.00118 YRSCHEM RSquare: `Summary of Fit 003628 RRoSoqtuaMreeaAndSjquareError 0014864 0057519 `MOebasenrvoaftiRoenssp(oonrsSeum Wats) 0036447 a OF AnSaluysmiosfofSVqauriaasnce MeanSquare Ratio 1 45 000560458 0.14887811 0.005605 0003308 1.6940 Prob>F 46 0.15448269 0.1997 Estimate SPtarWaEmmeotrer Est(imRaatels Probsf| 0000409L4I0T2T8 00001030091094 133709 00.01090947 0L0o2w3or19852% 0002998 U00p7p5e62r3s3 00006442 001410 = uPiarnttasratregsoeon w oo : . gone ~~ ww em I PE CT wa ree 13 AppendiEx pune RRRooaMenn5e7e0apgpSmp=e0.ES3r02co4r4 -m0.0a50s666YRSCHEMSpogroriienodn NreofvReeson Sio0n YSsooews osroTo R"ERsMoSTtviLmEssaRns dune sUdmonmnee eFSrunae oa oo bi Soon TTThonmcheem oCcioomtmoaoe oPSuHimEiaSsEs3sH om se pwooten vobmorensne uompaesreoessn 001411 PECGhSaFmAainocdmaolmOBSpyaemVrpAsliSreCsHEM mn 0 fq? El 3 _ aw SS w-os won mda 8 AppendiEx Page 14 PRO=0S.L1i2n3Ae9a1r-F0fi0t02o14Yp RSCm HEM RSqure SummaofrFye RSquare Ad 00000213415675 MReoaontoMfeRaensSpqounasree Bor 00019391351539 Observaions (orSum Ws) a SMooudrecle or| A"SnumooaifSVqiauraimassnco 001843661 MeOaonissaiusrTe 1F6ra7iio EnCooral 4is 0O76T756M61 00TSE 0P3i0ob7s1F TInotemrcept YRSCHEM 0IEZsiSmIa0l5o Pa0rSa9GmEeM6toerrEstim(a4Rta1els3o P0r0o0b2l LGooweorsdse% Uapipomredsew 0002035 000067 103 03071 0006299 Oooz0es 001412 oT scCaRhaapnmodmoBmyCSpvaaamrptSolGreHsEM Appendix Page 15 go . 2k : on+Vi w5oan + Es s MSS6fppm = 0S0u5r7m75moao0r.fF0y0t212YRSCHEM RSRRqoquouatMrreeeaAnGSquare or 00a000rs3s4i7s8ss6 ObMsieeravnaotfiRoensspo(norseSum Wigs) ogresas SoVuirdcee! or1 AMSomOosorfiSVtaaaruaasnca Me0ms0wu1e F3r5a% C--row ss o02z99s78 00si0 roerre IYnTRcoSrmCeHetEM mEstiTmate PacSrGoaEmlretoeerrEsti{maRStaeIsi P<oobomiil 0RUT ORS Am 00% G0Lo0wor0sssnx aU0dp0p0es0r0s 001413 Pros[ EopranBay-- aviAaSporEM Im AppendiEx Page 16 0-- !i VI dese ww PFOSAtppm = S0.u4m0Um4na4or6ya+ro0ir01t564YRSCHEM RoRKoqotuvrieeaAndSquareBor 00010528703492063833 ObMsienrvoattiRoensspo(nosreSum Wet) frie=n SNoiuos or| Aa"sSQioofmmiVeoaiesasn|MemOoSmweassr F20r9a8 TBoaral 2a CSotEsssGrs 0307 b[re5we4r YITRnoeSmrcehpEtm oCuomia OGPaurkaEmnsetaer Es(tR3ao3is6s P0ob0lMl GLoownroossx Uopmpmeorroessw 00is8 Goons 173 Ooo Dood oor 001414 RaEnngdionmeeSraLmapble PEHS pom By YRSCHEM. TM w 2Z 0 a w-- I. : ra' oS wos mon on oB ow wow APpapgeend1i7x E MSooudrecle. ErCrToorul TInotemrcept YRSCHEM 'PFHSdfppm = 0.L1i0n6o57ar+F0i.t00439 YRSCHEM RSquire Summary of Ft 0065012 RRSoqoutaMreeaAndjSquare Error 0.002230047879 `ObMseearnvofatRieosnpso(norseSum Wats) 0.1709233 OF AnaSluysmiosfofSVqauriaasnce MeanSquare Ratio 1 21 00777620 11183544 00776 0053255 La6oz ProboF 2 11961164 02403 Esimalo PSardaEmmeotrer EstitmRaatioos Probl 000.01403635663% 0000701738613 112418 0012542053 L0o0w4e2r79056% 0003162 0U5p5p8er4s5s8k 0011935 001415 RaEnndgoinmoSaraimLpalbe TM POAA ppm By YRSCHEM w Ew - JA | SS wos a8 wo NB 0 APapgpee1n6di&x MSooduercle ErCrooru InTtoermcept YRSCHEM POAApPM =0.3L4i9n07ea+rF0i.t00185YRSCHEM RSquare SummaofrFyt 0002389 RRoqoutaMreeaAndSjquare Error 0050245571172 OMbesearnvaotfiRoensspo(norsSeum Wgts) 037627E8d OF AsnunaolioSfyqVursiiaeinscse MeanSausre ' 0138962 001389 FR00a50o3 22 5588013798339568 0276378 P0r8o2b6o7F 03E4si9m0a6l9o PaSrUaEmmeotrerEstimtaRtaleos 0163524 213 P0r0o4b7l 000IBS2 000869 022 0847 L0o00w9e0r094%6 -00ISM2 0U6p8p0e1r5s4s7% 00190509 001416 PFOSRAaREnndpopomnmeSBayanmRapsSleCrEM w AppendiEx Page 19 . Ba1 Vis ] Ea Ee won PFOS=0SAL0uo1am7A8nm5aFodrft0F0yif002y7YRpSCHmEM RqRRououtrMeeeaAndSquare ror 00"001005161s4274 MeOearnvatiRoensspoorsSem Wes) Qoi3sa=y SVoiuerr orTo A"nmCToaoofwrVoyassinseacse Mem"SOuommos Fonrsieot ECmorat 32 oOMoIOmNS o00ue P035r46 IYnTRoamSrCaHEM OEOnMa POSaOrWGaEmImeIotTrerEs1tPo2a9ls5e PGo0b0l GLOoSwrIoSsEk OUppberossw 0006 0009 OF 036 00001 ooo0s7er 001417 -- Ee n-- Trr le "w = -- e--n RSEBEqeuRatrEe oene Rp0s.0ir0i0m0o2s47 w pN mm,oon t TaRiEsE wea AnalofyVasriiansce =oe BHie,m occmomee SsDHeEnmEE eERsEOBmEw gOeEs mspmre 001418 RaEnngdionmooSraiLmaphle PFOSA pom By YRSCHEM r) a . " a E wg B [=-- a EEE REE wo Arpapgeend2i1x E SMooudrecle ErCrooarl InTteormcept YRSCHEM PFOSAdfppm = 0.0L1i4n7e5ar+Fi0t.00015 YRSCHEM Rquire `Summary of Fit 0007656 RRoqoutaMreeaAndSjquare Error 0.00.203304976 MOebasenrvoaftRieosnspo(norseSum Ws) 0016839 OF AnaSluymsoisiSofquVaarrieasnce MoanSqume 1 000008605 000086 F0.R1a6t2o0 221 000011112145040094 0000531 P0r6ob9osF Estimate PSaWrEammeotrer EstitmRaatieos Prova 0000010417445895 00000007316639 024006 0060951243 L-o0w0e0r0dISS% 0000608 0U0p2p9o6r5o6s3k 0.0008998 001419 wo 558RaEgnondoanonmBsyaSraYimHapSnlCeHEM nm : " wu Fol m7 JON Vi woaEn Ee Appendi&x Page 22 ESVoiouorcle Crom TYoRSmrCeHptEM MSS=0S60Lu1in8nmce8aar0n0Fylu0oF0ft0p1YRpSCHmEM RRosRoqqtuuMareeeaAndjSquare Err a0"0o00o0a07as476 ObMseeravnaotfiRoensspoonrseSum Wigs) ois=s Aas ofVariance OaFli 2 Sum0O0o00f10S5Iq70u90aL2r06e74s MeaO"n"0oSoqoou0a0:r1e P0Fro5oRoaw7ateli%too OEIinEe PaS0rUa0Emr0eot8rerEsti(mRa2ta2el0s P0o0boNlSl LOoowoleosrssE 0000013 000031 003 0975: 009i UpGupsoirosrsess oosesmae 001420 smaege mrAppendiEx ErE ooyet-- nt Eo CC i = CA`Source OF ww SumofSquares TRTT MeanSquare wm wm%FRatio wm 001421 PHSRpaMonadmionmoBSnyaaYnmRcpSalCeHEM w . "w ww -- :w C5 ns a 8 wn PAapgpee2n4diEx SMooudreclo ECroou TIonemrcept YRSCHEM PFH=0S S.L1ui2nm6Ao7+mara0oFi 0ifrt1Fyi1t9p4 YRpSCHmEM RSRqquuaarreeAdj 00216719555022 RMoeoatnMoefRaensSpqounasree.Eror Observations (or Sum Wa) 00223174405958 i OF1 A"snuncosifVSayuraimassnce 014611866 MemOSlauiaoe F3r1i8mo 05 005451826545191717 0045838 P0r1o0b7o8F 01E2s6i6m9a7t4o ParSaWmEeMotrorEsti(mRataels 0088 142 P0r1o0b7l Lo0w0e7rSdE5R% 00LI%4 0006 170 01078 0008 0U.p3p3o9r26s3s 002708 001422 RanMadionmteSnaanmcpela POAppm By YASCHEM BE] m _ g2 m mw AF wtCs -- wos om o85 nse APpapgeen2d5ix E MSooudrecle ErCrToorul ITntoermcept YRSCHEM POAApP = 1246Li5n1ea+r0Fi.t02555 YRSCHEM RSquire SummaofrFyit 0.039706 RoRSoqtuaMreeanAdSjquare Error 10..30460659399 `OMbesaernvoaftRioenssp(oonrsSeum Wats) Lag34ss 1 OF ASnumaolfofSyVqausraieianssce MeanSquare Ratio 91 106..16783743014 016769877034 P0r3o7b2o1F 10 16842135 05569 Esimale PaSrdaEmmootror EstitmRaatleos Probsll 0L0224565S5IL2L7 00506401586878 02262 0050556292 0L0ow2o1r89951% 0.069206 U2p5p1o4r6o1s3t 0.120311 001423 Pro[ mtrrm-- Sea t eu srepeenaix m1" go _-- 2Fiol ; wd w TTT we + Es RParerO=--00J 5S43--0A006oYRSm CHsEoNon: RRNeoomtoeehageSnuee Er Chumaion to SumWee aSiiossse % J-- EESSroEurrr.ce OoF5oTS dcoemmm SumofSquares o"noama MeanSquare eFhfRiaeote?iado fTTronm e oCcosowressse PcoSumoHmomEmasSs com43a08 bwoommyle Leloesreetsn umSpbpeseoeroms 001424 570RaVpnoamdionBmoySnaaYnmRcpSelCeHEM Ww fo _ EA -- w w+$5 nhwowWa 8 a APapgpee2n7diEx SMooudreclo ErCrooru TImoemrcept YRSCHEM MS70ppm = 02S6Lu0i7nm6ema+ra0Fo.rif00Fyi0t79YRSCHEM RRSSqquuiirreeAdj RootMeanSquare Eror 000.0110971479 0201468 OMbseearnvaotfiRoensspo(onsSeum Wets) 02680911 of1 A"nSuamlooifySVamsraiaminscse 000064018 Mo0m0S0e0u6a4o0 F0Ro1asoH 15 003366559304332319 0008 p0r5o0v2o8r 02E6s0i7r5a9t8e Pa0r0Sa8Wm2Ee4mt7arrEsti(maR3ta1esl0 POro0b8l LOowero9s% 0000706 0006295 O13 0028 00145 GUpepiorsdssw 00150317 001425 TE proRpsaemisasre i" rscepesngis '- TTT wa A AFgu rO=0SS0wu0amraeagnonudsstYtRSCmHEoMot RROSMohqouoimasoriilenoAFendSsjqtor Ec um Wi) So0.0o6s2n5i1 ESsrooueco or 5 hS"TEitoRfVIasEr omit mGbsoomseEs mFGrehe oa 0 en pect TTromscahe aTcooommnmse PoSuimHsasEEsimNaxes cms om poooxnaiy lsSooewwemes uompoemnp 001426 = I [ a!-- AppendiEx Page 29 " _ i w=ee l TTTear wo 6=.p 1nn3a6ar+y0wo00o4m 8 YRSCHEM RRoRoqotuneeeanfqr Ee Sooooaon CNtevcnmaioenot norsSam Wes) orei fsowu orEfMrEar RcEvLarYa san rai HEro 05 oOfieer oo eoao TTroamectei oCfufria oSJ vHe Ta3em Poowohl Goo Gomes a3 ose Lchoovmwos UoUppmoereomerx 001427 RSaunpdeormSvaimspolre we PEOS go By YASCHEM us : " Ew oo La : : w ERC- ACAEAEAret EA) ww APaogpee3n0di&x SMooudrecle ErCooral TInotemrcept YRSCHEM PROSdippm = 0.L2i6n8e8-a+rF0t10578 YRSCHEM Rsqure SummaofrFyt 0197186 RRSoqoutuMreeaAndSjquareEror 203.64678021 ObMseearnvaotfiRoensspo(norsSeum Wet) 18790712 OF1 1n6v 2E6s8ti7m8at7e 0105769 ASunmoiosSfqVayuraimasnsce 29.0612496551 116416 SPaGrEammaotrerEsim(aRtaolso 0l20l5s63sS2 01928 Moa2mS0a1u4a6o F3R9a2t9i9o 56018 P0r0o6b4F9 P0ubmslml Lo2we8rd2S% 006 000733 2U3p1pe4r6o7s3s 02188905 001428 fJ rm AppendiEx Page 31 br -- - EX on e R t=te,er sSSiuiuesits BA porao J CEpREmSA eTnim OaEe EBomew,e ocfumtm oSESmgEEoREsWewE tm R iummsm ooumsme 001429 = PRSaonnsdo omsSaarra ege " " FApepend " -"" TT wu - R + POAApp Rsque =03a08mn4e1en+ ro5s23 YRSCHEM osss NRReonotoefeRaegSpooesEc Craton orSum Wi) Srfaoteemds sHSooueeco o6r' [ CERS-- NeE sem denememsm eFSroeee Sou Bone Sos fTTronmee Goocwomminmse ooS[eUmmE--RT--o1Eh% pGooolyn LoTohewmeesns poTplesse 001430 SRuapnedrovmisSoarmopmlte PFOSAA ppm By YASCHEM TM TM APpapgeend3i3x E -wm Pos ows nono o8 ow wow SoMoudrecle ErCrToorul InTtoermcept 'YRSCHEM 'PFOSAAdppm = 0.L0i0n5e9a5r+Fit0.00023 YRSCHEM Rquire `Summary of Fit 0036993 RRSoqoutaMreeaAndjSquare Error 000102293227 MObesaenrvoaftRieonsspo(onrsSeum Wats) 001058168 OF AnalSyusmisofofSqVauraieasnce MeanSauare Ratio 161 00.0000021607237712 000000006073 P0r6o1b4s6F 1" 000277643 0.4485 Estimate SPadrEammootror EstimtaRtaeiso. Probl 000000052426835 0000000626961 007889 0043484459 L0o0w0o8r196s4% 0000389 0U0p2p0o0r5o6s2w 0.008463 001431 W MrSTinmivrahe.e "w : fo _-- 2m = w TT w T+ n-- e wu as+ e PAaogpee3n4dix MSTopm =0S05un3ro3+mu0oar0f0Fn3i41 YRSCHEM RRoRooqo:uMmeanAd SquareEro oGGoos0so0ss6itsssss ObNsearnvaotiRoensspoormeSum Wei) Sais AnofaVarasrce VoSoovuioreace DF 016 `SumSOo>lf Ssoqwua1eeress a comes Mean Square F Ratio memese TTTRosmtcHEM iCosimnase PoaSnaeaEosrr otimRt0sel6se oPowbiel om Wms lol os aLoomweoirsoesw oWUphpoeermsesw 001432 PrRoSaonordeoemBmnSyraovrtino . " , CT "w HAEwCnAACC:ArAarCar Aopendix Page 35 RqPuRrOSeAdam =SamL-aoru0os0i0t0P04833YR5SCH8EoMnan RNRooeovnt eaaARndeSqugarse ror Ohiration tor Sum Wet) cGioossirstsss fA EsoVrouoireo o6rTo AMnnTesooftvnyamrsrnsce Oda MnCoSoummmeees mFhreaireo Ero 0 ous oe nTRoemsnctEm ooGmmoiEneane PuosSmuEeortoorrEsimiaRDiaanlsse ome La Poorreimm oaLomwoeerommsk oUUsmpnoereaos:w 001433 RSaunpodrovmisSoarmMpglmei [0] M556pom By YRSCHEM ~ i" " fuwm . =m Los . . w Ss on os om os on oB ow wo PApapgeend3i6xE MSooudrecle ErCrToorul ITnotemrcept YRSCHEM MSS6dppm = 0.L0i0n7ea+r0F.it00261 YRSCHEM Rquire `SummaofrFiyt 0.105382 RoRSoqtuuMreeanAdSjquare Error 00.004894436692 MOebasenrvoaftiRoenssp(oonrsSeum Wats) 004168 OF1 ASnumaofloSfqyVuaasriiieanssce 001341369 Mes0n0S1q3u4a1r4e F1R8a8t4i7o 71"6 001121732887527067 0007117 P0r.o1b8o8F7 Esimtlo ParSaUmEemtoerrEstiRmaateos Probl) 0000027601118 00000413940327 011367 0018875377 L-o0w0e9r99106l% 0001421 0U0p8p5e0r64o4s 00066428 001434 RMainldOopmeSraatmoprlse PFOS ppm By YRSCHEM TM m )w DRE ACA wo Appendix E Page 37 001435 RMainldOopmeSraatmoprlse PFHS ppmBy YRSCHEM Te Eo wo, 1) eos ws wow wx AppendiEx Page 38 001436 rom[ pCeanBry-- eamsscrEn i. :Zim w TTT we AppendiEx Page 39 001437 PFOSRAaAOndopomomrBySatmVpoAlSeCHEM py w w Ew Ce wow e y APpapge4ne0diEx 001438 Saadeh W670bMiolrOspBeyractores n Eu 2 w " TTT win AppendiEx Page41 001439 PFOSRAMainlppdOmpoeBmryaStaYomRrpSslCeHEM. I) Em o " Bo B vos own o8 on ET APpapgeend4i2x E 001440 RaMinldOopmerSaatmoprsle M556 ppmBy YRSCHEM I) as ow aw 2m " ow LC AE wo Appendix E Page 43 001441 APpapgeend1ix F AppendiFx Scyatetaerrsplwootrskaenddirnegcrheesmsiicoanle(quYaRtiSoCnHs EfoMr)flfuororaollchreamnicdaolms s(anamtpulreal(nlo=g t1r2a6n)safonrdmfaotritonw)oby current job cateogries (chemical operators and engineer/lab) 001442 rsaarge AppendiFx Page 2 wl el nh Egho. . am - Lo. Trei o er EROS spe osrSoeamrsopest ves J SSoa eomtreitimereeree ooHaHz]t i S=r oos.e o3m ; AC naBlorfyVamsrrim ians ceS a aiil 2 rfomy hSteissm ccaShomamamtEEsiEmH1te7s mfsd toleowesms tSuihppuonno 001443 InPFHRSanppdmomBySaYmpRlSeCHEM Ir . "w wl wli an et : Teor Emr0 -r ct . . ns vs hnwons ssw AppendiFx Page 3 SMooudrecle EnCeTroul TInoermeept YRSCHEM In PFHSdipp=m -L2i4n0e3a2rF+i0t.05366 YRSCHEM RSquue SummaofrFyil 0236894 RRoSoqutuMreeaAndjSquareEror MeanofResponse 0L203027339 1752 Observations(orSum Wyts) 126 OF1 A"snumosoiSfqVueyarriaesnsco 425612 MeawnaS2qsuerse 3R8a0t3i7o 11254 1148265.61394868 L197 PprorvF 2E4s0i0ma4t8e PaSrWaEmmeotrerEsti(maRtaesl 0146366 1642 P<ro0bl Lo2w6o9r299s5% 0053664 000864 620 <000l 0036S? 3Uplp1e3rsodssw 0.070783 001444 In PfOAaAndpopmBmSyamYpRlSeCHEM Sra . I By ah gl LE Sr . : "+ Vinhonass. PaAgppeen4 diFx SMooduerle ECmrorat Tormeepe YRSCHEM 1nP=02O0Un0o7aA r+F0it00A738 YDRSCpHEM SummaofrFyi RRRoSSoqqutuarMreeeaAndjSquare ror 0L".ao0so04ea2rs5)s2 MObesaernvoatfiRoenspoonrsSeum Wet) 010610256 oF1 A"SnimoaioSfaVuaiarrieasnsce 03365 MemmSeqsuse F0R5a9t 11254 1199657528472659 1598 Pfrreed 0C2o0i0n8s PSOaErlarmoeytrer Esti(m1Faat1el7se P0ro2bl Loowserms OTT 0001 073 ods oles Uopmpmeores obaradss 001445 = In FORRanpAdpommSaBympYlReSCHEM ES fu Se TaJu eeTELreTaT Tin wEens aw AFapgpee'sndiFx In PROSS=Au4nm.a4amAr7a8Fo-rtfd0F0yt2i366pYRpSCHmEM RRoSRqoqutuaMrreee.aAngSquare Error 0oL.ga0as3ei2si3ts21yr ObMseearnvoafiRoenspsoonrseSumWis) Sa1m SoNuordece or A"nSamoiiofSyVqasurieiasnsce MemSur | Sharzs sens Fsnralae EnCeoru 11254 2265671555426060 20708 P0r0o0m TIYmoRrmSeCHEM aEdsminoa%o POSarWiaEmsmeotererEsim(maMtaeelse P<roombll Loawseerrssse% aUppoordssk Domes ooues 204 ooo 00weT 000 001446 nM 57R0anpdomomSByamYpRlSeCHEM EEN wipe 20 {3s a Swine, and" .- ees ; "50 Vin% s - as nsw woo In$70ppm =-23U5n3oa-r0Fi0t126YRSCHEM Summaryof Fit RSquare 0015641 RMRoSeoqautnaMroeefaRAnedSsjqpuoanrsee Error Observations (or Sum Weis) 0"L.i20t50217i4712502t326 Source oF A"nSiamololfySVqasuraiimanssco MemnSqure EMondoerl 124| 15234.34871676 212a58 Col 1s 155.8583 IrYTRceSremCpHtEM Parameter Estimates 20E31s52ti05m39at66e ~~ 00SI0tSd0IE8Bm7So4Ir 1t15Ra45ti00o 1F9R7a0i3o p0r1o6b2o9r <0Pr0.o06bs02l19t AppendiFx Page 6 . 001447 w ineRroaRndoommSoaymvpleescrEw wml a ae . faowld o, mee--s EI P an Je oo TT w wn s Aopen Page 7 tnprosaatem=S4ro1a5m6sat"oFnrtto vasciz RRosqtuee ag oproeosmtaosns NRaCoonhtaoMeiaFnnesSsqputoaorrSeesEurmrWores) ipr 1.899215 SEsahruacrse or' [RreSRnr-- WenMsuem Fra ni wm am met Croat 5 sine an fruToiem aScoamhmbnaamaoS`rmGEeocEnwomsriiugsnse oSovoeermes UoSpoepenmr 001448 inM55R6anpdoommBSyamYpRlSeCHEM wd . FE EE En i Ta oen SUT ER I . "an CS ns an woo APpapgeend8ix F SMooudrecle EoCTroul TInoemreept YRSCHEM In MSS6dfppm = 3L.i6n3e6a5r-Fi0t01244 YRSCHEM. Rsquire `SummoafrFyit 0010236 RoRqouturMeeaAnSjquareError 0103062229574 MOebasnervoaftRieosnspo(norseSum Weis) "379610236 or A"nSailomfyVoasreiiasncse MemSao FRaio 141 230213250806 2L3E0S0S p1ro2b8o2r 1s 23250588 025% Esimels PaSrdaEmmeotrerEsti(mFaatelso Pobsl 6003164459 000110899869 19-L5163 0<020906l L4o0w04e5r3s9 001% 3Up2p6o8rs3s5k 00093062 001449 J_, -- AppendiFx Page 9 1" : So : z Se - eHoe w--k" "i SBaEy . Root Mean Square Error 320589163 2pZTr %i:: J YE wEn X2 "GBre. ZB y TA E EaT Ew Z wn 3 --um 001450 Random envio In CPhEeSmipcpamlOByperYaRtSorOsHEM us . "w PE " 3 5 Rs 2 59. Vindwi 8 2s APapgpeen10diFx InPHS pm =S1Lu7i1nr7e6raorf0yF.t0.491 YRSCHEM RNRSiSRqcoquaoutnaaMorrifeeaARnedsjSpqounasree ror 0f0o3.3341r5s053758 Observation or Sum Ws) pl SNoouace ori A"Snimoso5ifS7sVqyeau0ra0aensrsca MemTSqsaoe aRaeo ECoral "ss 21582478818005 04068 Pprorbear TIonempt 0Gi6mae OPSaMruaEsmreowtrerEstiilmRatahees P<oomwi LosworSwsnx rUpeposrssss YRSCHEM nS 0002 4% <ool 0mesiE 00a 001451 PE[-- Co Chemical Operators Foe ti AppendiFx zEw dT.: . z Tan TT AE wn In POMS = S031n0ao08u4rn5F01t132 YRSCHEM RRRoostwaenAgSar Er oooeososnceitee NOehvnrvaaonssr(oor Sm Wes) Seine SVHooorieeen or: n"Baelotvreairtna Wem"sSwwhn Ffuoee 5 Bina owen meer oat @ I870ases es TTrosmcahe oSGtuonmases cSJ uitrna -- Ci3Ra%s Poooonl COB Comms 13 oss GoLoowowredosnx CcUphpooaroemsn 001452 In PCEhGReSamAnNidcpoaomlmSOpaBaymrpYgloRorSsCHEM TT a f eo ant . .. El . AppendiFx Page 12 Tame Ped : on Lee ee t C508SCH a8 Ws SoMuodrecle ECmTorul ITnoemrept YRSCHEM InPFO=`SS4Uu.n3omA6amr7Foa9A-ifrF0ydt019f59YpRSpCHmEM RRSeqquuairreeAdj RootMeanSquare ror 000.010286617 1603004 MObesaernvoaftiRoensspo(onrsSeum Wt) "4453a6 OF1 ASunmoisoSfVuayarrieasnsce 155397 Memm1S5a5u3w97e Foagoo 5i 117151683730014 25662 P0r4ob0a8r 4E2s6i8ma6l7o 0PS3aGraEamlmoe6rtrEsti(1mRa7at6ols P<r0o0b0il Lo4wsooradcsl%s 001954 OUSI% 078 04408 007034 nUppeerovss ooo 001453 Random Sample Chemical Operators Beg AppendiFx JL == Hg p P ae R=S J. FE TIwo-E sqnmSLo6Hmoaun0toP2vescrm ois RNROeannoiemcoeansqsrErWeg oEVaowrrss Fi Eesooame o$r; JVoRRssvSoLiwaEsEe esiVbEemD F&I rr5ease pres feTTam na dSfiaarramse [SooSorwmE--sRE--S2DhE vToolmy odSwohenensn uarpwcohsme 001454 FandomSargla In PEChGeSmicpoam lOBpyerYatRoSrCsHEM me. to an EE wie + EN *3 and Lo In Vn w8o a8 8+ s Aeotpeandix In PEO=SS-u3mn2mAa1er7ya4dr-o0F0i321p7 YRpSCmHEM RRRoquouttrMeeeAangSquare Er aoVo3u3asaisnsoin MOebasenrvoaftiRoenspoornSeum Wat) SSa SVoiurer ori An"sSinoefSSVaaasrsasrca Men"swUwTe h0al5o ErCroorat i 15R53s18s26 3 paezr YnTRoSrenCeHEM AE2ui0nd8o oPSursaEnmotrCaiUn1Re7as6l P<on0i ommm om Ll omw0 Laoowomerses Uo3ppoersomsw 001455 arco Sania nuCshempiocmal OypeYraRtSorCsHEM a wl .. i" --_-- fn EE Zn HU a a Sn 8s 8 aa oo APaegpeen15dix In Map =S2u7n7mo6m7uaorrf0.4y03141YRSCHEM RRRooaukreeaAngSuse ror GaTosaissiieszms MObesaenrovaftRieonspoormeum Wig) Sina fSoCNouroroacwe: Ou"sFi VTnRoimSeCHtEM aDEsominieae AnalofyVasriiansce SumoSsfoSSshqsouoeamrsneets oPaSrEaammeetrer EaRumseass oo 47 MeanilSoaqunwarsne mFfaRenartreio Foaoooklbos oSLoawvrmsessx oHUpepoesrmsssn 001456 mprre AppendiFx Page 16 io0o -- , 25 + ' WS Bepeee , InPFOSdfppm 0 cr SpuEm =-1.4007+0.03146YRSCHEM LBptaN tn Scpis2 B Bpm,oI onorT 0 ACnaE mEloRfyVamSsrEiiansce LE wrenn afoow IjB~lh oSwmamyes MITrmCEemTDamR wqoetRn mmEmme uSvnep 001457 J pense fT BITE id . . AppendiFx Page 17 rBoe 2r2r rmse EREte u2n co oEmRIeEn E BoEd gumA = iBE.o,m afcioomne B0-- EmEEESROEeRma i SmEeR muSp 001458 prs-- roee esix F onow . Saw Eawd a8 7 - : 1 : mR . 91 5 ano W--E sJom miEEttE eoe sia% wo om resL FE a i. ire EuEEsr re 001459 RandomSample AppendiFx Page 19 EfgEoaousl~ ) ~ 1 Ban, Fal . | am + 5 i + . rEooeEnerEoS s eeenr esr. oomhy A etme i: pcmoo J RUREIL weg, en Eiom, GoEr E-- REE-- IES HEOWrmeE umreEs 001460 RaEnngdionmaoSraLmapble LnM570ppm By YRSCHEM " : wf : APpapgeend2i0x F wn : sn ee] tS mBo oBos uo8 st SMooudrecle. ErCrToorul TInotemrcept YRSCHEM In5=7-3.L00i5n98ep+ar0Fp.i0t0m297 YRSCHEM Rquire `SummoafrFiyt 0.002026 RoRSoqtuaMreeaAndSjquareError 0901.50643575 Mean ofResponse Observations (or Sum Wes) 20161223 DF ASnumaofloSfqyVuasarriieasnsco MeanSquae FRatio 21 107..063056724179 0008335870417 P0r0o4b2o6F 2 17641966 0.8384 Estmele PaSruamEemtoerrEsti(maRtaeso Probsf 03000520776329 0002184448092 1007214 0<8030804 3L6o5we2r09551% 0026977 2U4pp6o7r4o7s3t 00329252 001461 RaEnngdionmeSoarmipable InPFOSA ppm ByVRSCHEM mq" . ot an _--] i SE Bon i : Elan an Cosmos non 88 wo PAapgpeen21diFx ITneormeept YRSCHEM SMooudrecle EnCToorul In PROSAfppm =L5i.n5e2a0r2F+it0.00865 YRSCHEM Rsquire SummaofrFyt 0004124 RoRoqturMeeaAndSjquare Etor 1806.40644383 OMbesearnvoaftRioensspo(norsSeum Weis) 53932253 OF ASunmolosSfVqayuraieassnce MeanSquare Ffato 211 703031052135540 03437062013 P0r0o8b7oF0 2 73317544 07710 5.E5s2i0m1s7t3s ParSaGmEeMtoerr Esi(mRaatloos 058 952 Pr<ob0o0lli 0008649 002933 020 0770 L6o7w26e3r3s9 0052345 : U4p3p1e4r0o0s7w 00696438 001462 rieSan frig AppendiFx ER Fool ane" 550 . w+n Jr wRite poST In MS56dfpp=m -4.7931 + 0.00973 YRSCHoEpuoMtstuas ee wg Lan S2souoss oAr: J CUSuAm me LWaeenmggeme wrfamwe 3 De pred Tromdtin CJfuahrvae Ga[ Eebnn-- T-- EioWR oekalyll llaiomesinr Utpemerstmatn 001463 APapgpeend1ix G AppendiGx Scatterplots and regression equations for fluorochemicals chemical(YRSCHEM) for all chemical participants (n = 187) for by years worked in current job categories (cell operators, chemical operators, engincer/lab, maintenance, mill operators and supervisor/mgmt) 001464 = er-- ode ev ns : " . fo Eq nhl PAapgpeen2 diGx Ta wn RoqPueRO= 0pr.Sei8hni0ian5d0i4np433YpRSCmHEaMxes NRReoowotteeaaRgbeseEre Laaaetarosom Cent enum) to SYsooou t 1o5r5: AMnRaoSfVirIhacse oa enMSeoskn SFhreae Choa we mem oon TfToammso QoCoufnsae o[ iSsueTwrsa -- C'R3Se Goons in Peeuabell Lomowmwaeass Ubwppieersessx 001465 TM PEHSAlpPpamrBiycpVaAnStsCHEM APapgpeen3 dix 3En Ltepn 1. 0h, wn r HA e ihe CS nswoansaow SMooudrecle ECoorl TInoemrcept YRSCHEM PFH= 0SS.1Lu2i4m6da3m+raF0ofif0rt1Fyi5tp54YRpSCHmEM RRsSqquuurreeAd 00220160588617 MReoaontoMfeaRneSsqpuoanrsee Eror 0033427182416 Observations (or Sum Ws) 15 OF1 ASnuamoliofSyVuasarimiasnsco MemmSauws s9%0711 S871 4Ro.aasoe 115556 228338645416734 ORI P<roo0v0o1r OEsMireGlo PaSrGamEemtrer Esti(mFaatelse OOM 330 P0u0b0sllzl 0L0ow5e0r8SS8% 001547 000268 705 <oMl 001603 0U1p9p9or0o7s1k 002041 001466 POApMarians PAopepedndi6x g ESN udoPE wm ww Le gs 1" Tor: toa. " T wo T A POAApp=m 1e20i60nn9ar0io9t1788 YRSCHEM RRsoqvueeAd to oGforoteoemwd NOeherovsiRonesptoo sSum Wats Cni SoVursce or' A"eEgSeiiees Me"nisea FGrau ECrhooa i5e Swoiirreees reno moerenn TSoamIchem hGmraee oSPabameerlnorEsimvaeees nPoubl Com owns 317 oo LOoooswoes UbCppaereomss 001467 w rosAirpnurcsoymhnsscren w Zi w I. Cb T raS a n a aw wo reespens noses [PFOSAAfppm KRqiuirse ag Sona = 0.03463 Roe an SeEo iF-0.00084 YRSCHGoEoiMsrzseoss oon ONbensottRepoorsSeum Wit) omewn Anaiscrvarance EfSCromulreocwe. DaIFTS `SumOoofmxSEqeuNarnSes MeaMon eSeqtuasare bPFfReaerteio VTJRousmcikem aafoommcme FoSaomHoa EEximSs7e5s omme A} poooonoot Looowwmrosysn Gouhpepoesremoss 001468 = wordAspacase " = " on TO i EA wou AppenGd Page 6 spp Re = 0E16s8Ra5r60eE267vRSCHEM comin RpKoorka ocnabgSeuse Ee Chaos SumWit fSSir2te0iao5ds 5 spSooors woor' AVEsootRviesEere dis dm"SsOeahewmne mFoamaie Tha mises fired onmmsce Sccuhomiimsme moSPUaimEmseSa Eo3nesl poonyms oodamwe UsEpneareoes:s 001469 rosl_ias-- Page 7 : TY oo CN onSO. Sa rseoeenSe ososwoaessoetss I 7 STsoceee orTo sUeLrgSTvEeameSmems L mwiens n ocoe =rioml. ORCBocmEm SSaErHErsmC MsS TmT emoem uupmoesn 001470 M5A8ipopmaBryicVpRaSnCsHEM ws we gon w =" vo JH| Do = rr Su oEaun saw AppendiGx Page 8 SVoiudre!o EnCeorat ITnoermcept YRSCHEM MSS=0S605u4mn8de]mar-ao0iirf.tF0y0t0o53 YRpSCHmEM Rsqure 0007159 RSquareAdj 0.001763 ORbMoseeoartvnaoMtefiaRonenSssqpouonarsreSeEurmroWret r0.0o7108264 or| A"nSamoloifyVSasaririasnsce Ooticos Mem0S0a0ass F13r26a8 118854 009510473840825530 0003 P0i2o5b0s9r 0SEMsEiImSaSs 0PaS0rUaE0mme6otrerEsti(mMa7at1le3os P<u00b0lI Lo0w0r6sssk 00028 000045 5 0259 000M UOpupsesrnoiset 00003767 001471 rrses mesi . Fw . Lt wm . ERSe5EqEuE aEr.te eeCnQn E izsi a:023418 EBpprmLe=% pCTpETnhoHEEeEE Lwaoemg Miomoe - a i" 001472 CAolllPOarpteircaitpaonrtss PEHS pom By YRSCHEM TM APpapgeend1i0x G 3En < . . wm LE E = E I so SMooudrecle. ErCTroourl InTteormcept YRSCHEM "PFHSdfppm = 0.L0i6n7o3ar+F0i.t05293 YRSCHEM RSquire `SummoafrFiyt 0573083 RRoSoqtuaMreeanAdSjquare Error 0512095 0.464481 MOebasenrvoaftRioensspo(norseS:um Wgts) 09266119 OF ASnumaofloSfqyVuasarriieasnsce MeanSquare Ratio 1 7 2105017021593835 0220151754 P9r.o3b9o6F 3 35374519 00182 Esimalo ParSadmEemtrorEsti(maRtaeso Probl 006734 0052932 0359316 007268 0.19 307 08567 00182 L0o9w1e6r99857% 00121003 0U7p8p2o3r19954% 00937637 001473 AtPartcpants IF] POACoplplmOpBeyraYtRorSsCHEM 7 " Ew . wn "w Cs W o~ aA B ws wou POAAppm = 025L7i9n4ea+rF0i.t08268YRSCHEM Rsquire `SummoafrFyit 023489 RRSoqoutuMreeaAndSjquare Eror 0508304811193 OMbesearnvoatfiRoenssp(oonrsSeum Wgts) 18105556 SMooudrecle. ErCrooru AnalofyVasriiansce OF71 Sum of46S79q34u46a06r43e23s Mean04S99q64u26a06r13e 8 11680674 TInotemrcept YRSCHEM ParaEmsetitmearloEstimateSsWEmor tRaio 00022567893453 00073568416437 202314 PF5r.Roa4tv2io0o oos77 P0r7o4b%l 00577 APapgpeen11diGx 001474 AClolllPaOrpteircaiptaonrtss.. PFOSAA ppm By YRSCHEM ws APpapgeend1i2x G -w [EE we PFOSA=A0.0Ldi3n0ef3a1r-Fpi0t.p001m12 YRSCHEM RSquare `Summaroyf Fit 0418421 RRSoqoutaMreeaAndjSquare Error 0335339 0013461 `MeanofResponse: `Observations (or Sum Wis) 0009223 9 MSooudrecle Emor C Toul OF AnaSluymsoisfSofquVaarrieasnce MeanSquaie 71 000000102961824549 00000000198113 8 000218103 InTtoerrncept YRSCHEM ParEasmteitmaetreEstimaSteWsEmor tRato 00303118 0010413 0001123 00005 291 224 5.R0a3t6i2o P0r.o0b59>7F P0r0o2b2l]6 00597 001475 ACalllPaOrptoircaitpoarnst.s M570 ppm By YASCHEM 3 us Eo HS us N= . "w vs wos mos nos wo APapgpeend1i3x G SoMuordecle. ErCrToorul TInotemrcept YRSCHEM 'MS70p=pm 0.Lin1-oa0r03F.i0t703614 YRSCHEM Rquire `Summary of Fit 0380736 RRoSoqtuaMreeaAndjSquare Error 0292260 0.040686 MeanofResponse Observations (or Sum Wgts) 0.044833 OF AnSaluymsoisfSofquVaarraensco MeanSquare F Ratio 71 000010175182747326 0007124 0001655 43037 ProbsF 8 001871208 0.0767 Estimate PSadrEammeotrer EstRimaatoes Probsll 01037558 0003138 0000301I4S7I43 230370 0000176372 Lo0w0e2r99353% 0006715 Up0p1e78r19851%6 00004388 001476 All Participants. AppendiGx Page 14 .Z E-BHeireaenpremHtBo =moyo TTVEEEE ewmm om e Be mEEBicEaETl Ewm mEe Wam 001477 An partpans 0 sssCelrlsOpBeyraYtRorEsC.HEM w No nn -- A V ew8TS Ndsa won MSS=0tS01uL8m3do6mwaos6ifr.F0y0A0p25 YRpSCHmEM RRsRooqouvtMreeaAndSquats ror dDooolasiersnes:y ONbisenrvfatRioenpoorsSum Wis) Gorse5 SoNuoricre orTo A"nm"TsoofooVbayirmetsassnca Mem"Sowowoe Foriast EnCeorat 7 oomommmy oon psemre ITnoempt [ oEbriattso--oSoHmE (hoalso Poroobml YRSCHEM Owmse 00 os aso APaogpee1n5di6x 001478 PEGGSrAopnmppmabryiOpcespraAanStsoGrHsEM Ww in : sa . . 3Enf.e " . . w= wn wt w+Vw woRu ad ss AoperdiGx Page 16 PROSUfp=m LS4uSU1mn0o5m4aaro0iri03y765 YRSCHEM RRsoRqoquutirMreeeaAngSquare ror a00osmssss9e6 125103 OMbiseearnvoafiRoensspoornsSeum Wits) 153906"2 SNoiuors or1 ASnimof7av3o6a5r5sas0nco MemS3aa%re Ranaois JCoym a@ 105474003142755 Is6s08 oProoar VTnoRmrSCgHEM LEsSimaIte oPaaSrGsaEmemeotsrer Eti(mRaoatilolisa PcOoDm LoowoersrSk Unpepsosreoss oosess oom 2; oom oon o0raais 001479 = P i apr r ap srepyendix En . : }Lo ana TIVEwo AE Bq[E aJ ryytoS 1S --oasesis NfEerpnaraeRAdo-- os frSriaionened CronoSum Wi) & Anastars SSHoEoourrace: OS@Fsi `Sum soScf Shaqouemarmwies eMse Mean Square AmoF Roeeatoeio TTormsocain Gocoumbmwie CSPaoHraeEmesSterCiNmE aE o boy oom is Cowl ombwonense pompeeorronae 001480 PORGNrAopmoipcmaarBCycppoSaaAniSosCrHsEM 0 : i - sw . g" . 2Swm,o Ln ea wm . Vn w8o nd as Aopendix Page 18 POAApPM = S7L1ui4n5me6ma+r0aoF0rft4Fy6t74YRSCHEM RRSRSqooutrMeeaAndSjquare Eror 0010.2806710399088337 OMbesaenrvoaftRieosnpso(nosrSeum Wes) 215623a4 SENorouorarce of| ASunmoslo1fS1Vu5ya5mr6mn6ss6co MemsSswass R7a0o3 a 555717 1629 promr Crow @ 13s Solon oYTRroSmeCHsEM [EEsrmeee eSPadrEarmmeotrerEsti(mFaatelse Pobi 0075 00USls 265 aol vLOoolwirvssasdxsBR Upporos oosissas 001481 = erCorSaaPnmermhooyrn wd. i, Lot " TT wo S AppendiGx Page19 RPoRqOuSeAAdfpm 0-- 08e55a-- 1r000136YRSCHoEoMsass NRReoowo ateaRegbpoes Ere Ohirvatin to Sam Wes) SSSooomeaemn SEoornr orTo As"oBloonoveamtta oom Mmohsagegaesse AFhaoTswToe Eva a nem on fnTseomnt ODeSn6Ee cPSHaoEsiSo EtRaitEses Goon ie pwdounmo Lmeowmsen sSppuoenroeas 001482 ChAemlicPaarltiOcpiepranattsors Ts MS70 pom By YASCHEM w w Lsw 2w 09 1p i Jr C5 woo no58 s k we APapgpeen2d0ix G MSoodurecle ECrTroorul InTtoermcept YRSCHEM 'MS=70.3L07i2n6ep6-ar0pF.i0t0m856 YRSCHEM Rquire Summaroyf Ft 0031978 RRSoqoutaMreeaAndSjquareEro 00403116430644 M`eObasnerovaftRieosnspo(nosreS:um Wet) 028442 Pl OF `'ASnumaooflfSqVyuaarsiraeinscse MeanSqua 1 0381171 038171 F2.a048l1 a 1111951398987032 0186110 ProboF 01574 03E7st2i6ma6t2e 000856 PSaWrEammeotrer EstitmRaatteos Probl O0G0B0I5O9I4S 144535 <00I0S0Tl4 Lo0w2s0r899159% 0020525 0U3p3pe4r0o9s5k 00033979 001483 _ Chemical Operators ow . : AppendiGx Page21 Be moghoaEoemrsnermEa oESE=VsEErEE nwam~Cmaymmom wm Source OF `SumofSquares. Mean Square F Ratio 001484 w oom T y mrAppendiGx . 2 mn = t : ow x Fat corre mSEsqemE,t eyt o sooommueses M55 =0.6 0970d 3-0f .002p 22YRp SCHm EM ES irae " m o2e 2g} Source OF umSemmmEmeR Sum of Squares. w"nEma Mean Square aioluF Ratio WrWoimmE outfmifrsie SoSSmHmErEaOIMBE rSmm olSoimen yuolameoas 001485 tome " : AppendiGx oEBoemmC,E Hb-Fe RootMean SquareError 0.504597 mem EEE mp me umm 001486 PEASpEtrnpooanhnoBceyprHainSainCsHEM TM w " -- wo -- " -- ot Vs nswo8 888 AppendiGx Page 24 PFH=S0.U08U0n5pg6a+Fp0it.0m0441 YRSCHEM RsRqquuraeeAdj Summa oft 00009615992749 RMoeoanoMfaRnesSpqounarseeEr Oervaion or Sum Wigs) 0011846005831 7 SNoouarce ori A"mnaoofnmavasers.snca Meonsuawne aFRssieo EnCeorw %3 1132735650542 00M PSrooeostf TInotemrcept 0EoiBnde PoarSouaEmmmtreEstIat1eR7s1 oPoboil oLowordls% CUphpeeromsx YRSCHEM 00oss 0032 ss ooesl coms 0oomida 001487 POAAAGlEDnPmgaiBrnyiccoiYrpLaAnaStbsCHEM IF i Ww Bo Emo 29 {= on C Hh rs m t ns Nsw woo rAapgpee2n5dix MSoodurecle ErCroorl ITntoermcept YRSCHEM 'POAApp = 030L3i4ne4a+rF0i.t00257YRSCHEM Rquure SummaorfFyi 0005873 RoRqoutuMreeaAndSjquareError 000.245205932 MOebasenrvoaftRieosnp(oonrsSe:um Wgts) 03427635 OF ASnumaolioSfyVqausraiieasnsce MeanSquae 1 00420387 0020 FER02a0i6o8 336s 77.11115685540893 0203329 P0r6o52o1f 03E0s3im4a4l3o PaSrGaEmemtoerr EsiRmaatoos Ol02 266 P0u0b6s 00025682 0005648 045 0652 L0o0w7s2r19151% 0008898 U0p5p3er6d7s6w 00140344 001488 PEOSAAREPoanrmgircBypaaVmnRsSCHEM PAapgpee2n6diGx wt ws, Eun . fa fog--0 w=_. "w CE waarngo e ' So RPquaOe SA=S0uA0Um1n2mo7daw1a-1rrtF0iy0t00p2 YRpSCHmoEmMsses RsMRqeooautnrMoeefsARneqsSpqounasree Bor od"oos0l0eiszss Observation orSamWi) 7 ESVoomutrrece ori A"nSOiwaocfmiVtaosrcasasrca MemGSOwNwEs 3 oom: Ooms pFbastso Coal Boomer 031 YITRnoSemCrHtEM oEoszaetso PoaGorEdanimosoirtr EstiImsa3tl0ee7s Poroobol 00001 0005 0% 03351 LG0oow0eormnssgs% oeUppesersoisw 001489 L Actpoucnr oasns w-= . fow] ------ 2wdl. .: ouf l . , Toa T AppendiGx Page27 RsMquse p =0f06nre0a0ra16RSCHEMcoos RNReomooeilaRegSsuose Er CraiontoSum Wit Sc"oSoonasrsiess S sBSoooureee o3rTO -- ERTLmE Obmm voMseoUmasmne mGFheruentee Ena than es TTJohimc oCfsouhmmeuse OoS[ Mueirne --U0SSa poooswnmlt lmdowaermsksex opUeeraoes 001490 aproerscahoemss sppeon wt . wr --_ wo -- oo Ere sS qm OY acso. ero..ote Ho[0reyae we sa porsz =s o2s orISr Ae CnaESilofe EAyV=asrSTiiansce wTeupimm rome oomt rTromlhe Gorhofgn SNsEOMTRrEoER MS p vFrN rlo%nmme sedwpeEns 001491 ssAEprPonmurBgy pevaAnnSsCHEM 3 fu. Be Pe " C~rI wanW s= aS e APapgpee2n9diGx MsS=060S5u1U3mnd1omaa0roi0irfF0y0Up49YRpSCHmEM MRReoSRqoqauutnaMureeeaARendsSpqounasree rox o000.00a05116r342389s5443 Observations (or Sum Wet) E] VSiorle ofi ASunmoooaooifiSVoiaeirniassinca |Me0m0S0miashe F0r4a7t7 ErCoorw 56 oOwBaIsT 00031 Porsest TIYnoRSemCrHtEM oEiumswa PuSoraWomoEltrCaiMna2el2se2 P00b% LGoowreossk oUpdpoerrossw 0004S OOS 069 049% 0001 oowmes 001492 ProsAbNioapmaatnBciypnyacRnisSsCHEM w= 2 w CZ igw. 1; ws . HEwR a AE CArC ar Appendix Page 30 PFO=LSS03uU9mn0Ae5maa0ro0iirl7y69p5 YRpSCHmEM RRooRoqqtuuMrieeaAndSquareEr 0o122xs0s3ei1s0ne4 ObMsiearvnaotfiRoensp(oonrsSeumWits) jE7 Ansof Vyarsa fSErourerce Coat iOissFI SumTo52ofwsS6thquii1asr%sest. lToaks Mean Square rGFhoReaartsrimos. YTRorSmCeHpEM LEoowuonitse oPaSrkuaEmavetoerEsi\mRa2st6lo3es P0ob0ol3l OLowwewrsns% Uepepemresns ome OBS 27 ols ooloTs oisie: 001493 AMlaiPnarttoincainpcaen'ts PEHS pom By YRSCHEM TM APpapgeend3i1x w _ Sos on o] wo os ws os wo MSooduercle ECTmoourl ITnotmercept YRSCHEM PFHSdfppm = 0.L0i7n2e57ar+Fi0t.02482 YRSCHEM Rquire SummaofrFyit 0551529 RRSoqoutiMreeaAndSjquare Error 00522417603515 MOebsaenrvaotfRioensspoonrseSum Wats) 030905n3 OF ASnumaolioSfyqVausraiwiasnsce MesnSquae 1s1 019.1125559435537 112594 006104 i 20414810 F1R8a.4t4i7o0 ProbsF 0.0006 Esimale ParSaUmEemtoorr EstitmRaatloos Probsll 0000274285166652 00000B7I7386 4032899 00.30806066 0L1o0wo0r89852% 002501 Up0p2e4r609154%5 0037132 001494 EyiE m Appendix Page 32 ; - oronvsporsgSpoms _ BEFhiE. RSquareAdj 7oyE0.169404 for rEEe ne on ww T spE re mn mi mm 001495 -- oes oy AppendiGx mq mq" TaEon ol Eo TT win Hrruseyeo5s5%aossssescnSsJannz SEoTmme Be5 BgBoEs40or CyeEmmRvmEmreS emmeem cmoeu ERomm a oCchoSomme DnSciEmanE mneSEooRmyl oommneer tSwhnmeeas 001496 1570AVptoapmrairBainycaYonHacnSssCHEM we. " I. fof --. wT : wm TT "w+Vi w8oadn as PaApgpee3n4di6x MS70ppm =02`1S0L6un8moa+mr0oaF0far0F2y173YRSCHEM RoRRoqqutuubreieeAndjSquare ror o0a0l3oe34ss3 OMbesearnvoafiRoenspoonrsSeum Wits) 023670w6v SoMuordcee or| A"nSaOuoyfmovsaariiasnsce Mem0S0aass 0Fru4io ECmorw 1165 o0ss4sseSor oom Parosoomr TInonmere YRSCHEM 02S1s0i6m2s6e Pa0rSa0GmEemStoerrEsm(aFt3ao8ls0e P0r0o0b1l Looowmreossrsk oUppmaroesw 0079 oom 06 0am 000s oom 001497 ProSAAMtpaaDorrmbtacypnaYraatSsCHEM oT " $i Zin_ OD ---- ow S - o w8oau s PRO=S0S.u0AG5nm9a5am1dra+Fo0trf.Ff0y0t06p9 YRpSCHmEM RRoSRqoqutuaMrreeaAndjSquare ror o2100609680901s7 ObMscearnvaotfiRoensspo(norsSeumWis) 00ssoswsv Ansof Vyarasnco ESSnCoiuororaorc!we D1F1s5| `Sumo0of3Soq6ua0or0es 033750082 00002 MeanSquare Tomrept [ oCmaemars--oSWbErior R1a20 YRSCHEM O01 00004 020 pFoRawotrimo fre P0ro3b0] osaes Appendix Page35 001498 AlMlaPianrttiecniapnanctes. M56 ppmBy YRSCHEM 5) " - [} 2 ma | -- vos moo a 8s 85 nS APpapgeen3d6ix MSooduerlce Error Cou InTteormcept YRSCHEM 'MSS6dippm = 0L.i0n7e8a14rF+it0.001 YRSCHEM RSquure `SummoafrFiyt 0011725 RRoSoqtuaMreeaAndjSquare Error 0-.010051461566 ObMseearnvoaftiRoensspo(onrsSeum Wats) 0.0877 1" OF AnaSluymsoisfSofquVaarrieasnce MeanSquare Ratio 1s1 00.0105158030899788 00001001383349 P0r.o7b8oF0 16 0.15684876. 06791 Estimate PaSrWaEmmeotrer Esti{mRaatteiso Probsli 0000071801042296 00000323347874 203432 0060739315 Lower95% 000000647076355 U01p4p9e51r1s8 0.0060704 001499 POASSbtlopmpoanriBtyscoYpraHanSsmGtHEM 0 ne w fe Ein ws : = pl w Vinuswonad= s+ de PAapgpee3n7diGx PFO=`0S.S-- 3u1m84mi+oaf0r.Fp 0yi9.4 YpRSCmHEM RRRSosqoquturMreseaAnlS)qureError 00.116s1u0s2s9s 2073295 OMbseearvnaotfiRoensspo(norsSeum Wt) imat2e SMooduerls OFi ASirmooiifSVsauraiaesnce 2452678 MesSnSurme rsoaoon ECnToorul zxs 112063016950206 9% pora Tomret YRSCHEM NEDviEa 0PS9air0Ea6mre0ot6rerEsti(m0aRt2ee4sl P0ro8bl6] 000% 003038 241 om L2oowswro3n5s% oon rUpepsariossw Orns 001500 E15StAppaorPmavriBtsycoYirpHhaniGtgsnHtEM TM Appendix Page 38 En . w Sinn Eond de wow TIonrmcept YRSCHEM SaMuodreclo EmCoTorul PRH=S0.S0Lu4di4m3a6mri+aoF0if0rtf1Fyi6t6p3YRpSCHmEM RRSSqquuirree Adj RootMean SquareError ooulsssiolnlts 037828 MeObasnerovaftRioenssp(oonrsSeum Wits) 0369124 oF| A"Snumo0osi7fS7Vq5ayur9ai7mas5snce MeoTmSen RSaasool 22 231443434969 01100 P00r2o8f3 ODEMsStSaItSe 0SP1aWr6aE5mme7tr3er Esti(mFa0at2els7e POub7l6i L0o%wseraodss% 00l629 0007123 233 00m 0018s Uopmpeerrs 003d 001501 SuAlplePravritiscoirpaMngtms! POAA ppm By YRSCHEM TM APapgpeend3i9x G wm Zw 7 m. = " I EEEEREEE so MSooudrecle. ErCrToorul InTtoermcept YRSCHEM POAApp=m 0Li.ne1+ar70F.i80t573562 YRSCHEM RSquire `Summaroyf Fit 0.193600 RSquireAdj Root Mean Square Error 01.118680201089 MOebasenrvoaftRioensspo(onrsSeum Wats) 12894 2 OF ASnumaolfoSfyqVausraieiasnsce MeanSquare FRatio 21 383..068560983050 810480023870 P5r7ob6o2F 2 41737735 0.0245 Esimalo ParSaWmEemtorer Esti(mRaatteiso Probl O00I5T385621487 000521279689 023450 0007234259 L0o8we8r99659% 0007505 1U2p4p7e2r29051% 00995444 001502 ASulpePnairstocirpuaingtsmt PEOSAA ppmBy YRSCHEM Tw w i wm -- . " Foo SSB as wos ow ws AppendiGx Page40 MSooudrecle Error CToul InTtoermcept YRSCHEM 'PFO=S0L.i0An0e5a6A4rF+i0td.00f016pYRSpCHmEM RSquare SummaofrFyit 0023751 RRSoqoutarMeeaAndSjquareError 0-001011460983 `OMbseearnvoaftiRoensspo(norseS:um Wgts) 0.009045 2 OF A'nSuamolofSfyqVuasarriieasnsce MeanSquare Ratio 1 2 000007599 000312335 0000076 0000130 0.5839 Prob>F 2 000319934 04522 Estimate PSaWraEmmeotror EstimtaRtaeiso Probsf 00056392 0000641 0O0G87 0002IS LI3 02693 076 0452 Lowor95% 0.00465 0000279 0U0p1p5o9r391s9t 0.006075 001503 ASulpePnairsicoirpaaMngtsmt M570 pom By YRSCHEM w " : APpapgeen4d1ixG 'oe EtE r EpEtEE nso SMooudrecle ECmToorul TInotemrcept YRSCHEM MS70ppm = 0.0L3i7n2e8a+r0F.it00349 YRSCHEM RSquire `SummoafrFiyt 0.081466 RoRSoqtuaMreeaAndSjquare Error 00.014237129054 MOebasenrvoaftiRoensspo(onrsSeum Wyss) 0.1097288 OF AnSuamlooffySVaqsruiaiasnsce MeanSquae FRatio 21 000338484344394661 00001364148413 P2r.o1b2o8F6 2 042279307 01575 Estimate PSadraEmmeotrerEstimtaRatlelso Probsll 002783 00034945 00000525369059 016476 0O510S970S 0L0ow7e7r4S9S3% 0001449 U0p.p15e2r09455%2 00084378 001504 au parcpants w PEOSSuApperovmisBoyrYsRMBgmOtHEM " : bo g . SI "w twa uosy ssw APapgpee4n2diGx SoMoudrecle ErCToorut TIontmercept YRSCHEM PRO=S0SU0un1Ao6ma5mrd+aof0ifrt0fFy0i33p3YRpSCHmEM RRSSqquurreeAlj RootMeanSqure Error 0o0o3s67s533 0126700 MOebsaernvaotfioRnesp(oonrseSum Wet) 00522627 oF| A"Sru0mo0ofi3aVSa0rq0iasa8snce Me0m0S3a3u0e R19a5o3 22 0O41I663E639 00ST P0r1o7v5o0F 0E0s1r63a 0SPaUr0aEmsomtrEstiPm0aa3tle1os P0o7bo6l5l 0Lo1we3rs%sn 000M) 0003 La 01S 0008 OUopoprearnesss Ooomass 001505 7 ueSAaFPoounrtcvaunens e [r-- Page 43 i 4 w_ . . wo E +rEwE n EEE Rqureitm = 0p0n0re6u7err0e0a0235YRSCHEaMsoi007 RNRoeoqaouioefeARedsSpqrEee Cheon orSum Wig) SGSooeoriroasant = EsSrourrs oBroTo S"maMaaofriovtnasanee Olnues MeomoSowmuwme mhFeoresmieea Croat no bee fir TVTaRosmmcehsEm GgEoioondss oE[ mnr -- UoiRs Omi Lei Pooosbilmel LSooomwmeeernss USopphooreonsen 001506 TM PrOSai1pPrOarbpyipuvaAsnSsorEM " zE w " vw 4 a a wa AppendiGx Page 44 001507 Aparicpans rvsMpilolmOpbeyravtioSrsOrHEM En z: we " Cin 7 8 a ww AppendiGx Page 45 001508 Aipatcons romMpialnOpyeravtores.re " , " TT we 7 7. ie AppendiGx 001509 AMiPlaOrpiecriaptaonrtss PEOSAA ppm ByYASCHEM 3 " w wn I:w BN HEE EEE sta PaAgpepe4n7dix 001510 AMlilPaOrpiecriaptaonrtss MS70ppBmy YRSCHEM ow I) ow -mn - Cos om oo8 ow 8 wo APapgpeen4d8ix G 001511 CsEeers go : iv AppendiGx 001512 ssaAioutpmapnBaycpiYarRntsSsCHEM I " 5 m " v3 ww 7 + AppendiGx Page 50 001513 Appendix H Page 1 Appendix H Scyaetatresrpwloortskeadndinrecghreemsisciaoln e(qYuRatSiConHsEfMo)r fflouroarlolcchheemmiiccaalls (pnaarttuircailpalnotgs t(rna=nsf1o8r7m)aatinodn)fobry two current job categories (chemcial operators and engineer/lab) 001514 : 1PEOAS PppmariBcy pYaAnsSCHEM - i: NE J a Lal = oN qn, i. 3 . J an SINE ns sw won PAapgpee2ndi1x InPFOSdfppm =S0u.4nm5am3ar+aoi0fri0y2935 YRSCHEM RRSSRqoquotauMreeaAngSquce Error 00009983310748 1002959 OMbesaenrvoaftRioensspo(onrsSeum Wet) "013112873 SMoouders oF1 ASunm2o0aio2fSV5qai9ru6iea8ssnce Me0m259e7 2F01a40o3 CETmorut 118865 2016836059660378 10059 P<ro0o0m1F ITYnoeRrmSiCeHptEM aEsti0mate 0SPa0ur9aEm9me1trer EstRim4aate5ls P<o00s0il Loowreors905e% Upapsosrosrssw mes 0006 44D <0 oolewss o00irass 001515 In PEWSAplppm aBcy YaRsSCHEM 4 eeh e, ERLoEh mp m Eo 2,06. IE Taanm. Teo an, ee . . . on V+ ins ase wo PAapgpee3ndix SoMouderle CBToorul TInoemrept YRSCHEM In PFHSUfppm =S2u.5nm3e1am1ra+Foirf0tF.y0t5519 YRSCHEM RSRqSuqaurreeAd 00222262328075 RoMeoatnoMfeRaensSpqounasree Bor Observations or Sum Wet) Lissoi3osnss 187 oF1 A"nSaumloofiyVSaswrieiasnsco Trent MemTSaGuaAre 54F1R3a7i6o 1h85 2Sl2e4d5s1s4i1l0 125 P<oob01 2Es9ta1te PSaWrEarmeotrerEsi(maRtaols OLN 20 <Poobmslll aLorweerdss% 00%SISS 00075 736 <0Ml Oise aUpvpoergssw oom 001516 InPOAAlpPoamrtBcypaYnRtsSCHEM ms Cpe Cle tpl on I {JE 2 -- Erg tL Tar EE So. 0 17 ECAAEC ACEC A woo PAapgpee4ndiHx SoMuodrecle EnColrow InTeormcept YRSCHEM InPOAAppTM = 0L.i3n2e8a9r+F0i.t00943 YRSCHEM Rsquire `SummaofrFyit 0006732 RRoqouturMeeaAnSjquare Eror Mean ofResponse 01020911386832 "021266 Observations (or Sum Wt) 15 OF1 118856 03E2s8i5m4s3s 0009318 A"SnunocsfiVSayqruieasnsce 3082705077625 3108503 PaSrUaEmmeotrerEstim(aRtaelso 0O0L02A3 213142 Mean2Sq0uwme P12a5o% 66896 p0r2o6v8e3r 0Pro0bsmll 0Lo6we1rS3S% 02643 000718 0Up0p5e1ro0s7k 00260493 001517 -- AppendiHx Page 5 mE Eo ga... Sa. aad DET Te FETHh, TER sIn PeEO=SSTaAeaot 0tA023M47YpRSCnHoEoMuss RNRoootaehagque Err opLneos Orato sum Wes fsrioumco woor: J"ER--SR-- ER ame MmsMSwesawowen feFreea Cha on TTohoimceh STCiRlroEem SveonEm SomTmEaeSn owen Da potowonnmt Laloommwaeism Uupsmmeoewssnk 001518 ae ET ERIS pol wh CLT Te sw. tt io AppendiHx _ BLs oL, a---Se pe esrcsfoonmaee Eig anes La2 rr or oCEn re rn on r--r -- we. EE TSE EEE 001519 eJ l wea wd], | See AppendiH x Page 7 Eg Somn E JqJ i Tl TT ean am J sent EX, --reS=Ts a t scvmars EEae RSquareAdj ish 0.002314 gEoTra evOEeERORRsEE , w"Egm irme `Observations (orSum Wits) 187 oEI rr frewr Ha SEEUEESR rer man men 001520 rio = AppendiHx mE he [TA FR EAE PR . eo onscJreveescrnmn fRsqueie wir Sombie Se paootoo ae Semel ee 2 Som or J CREE ee oYooa wo oamn em ofimvoeA foomm. SSfoHammRee CoStbhEowiEenSmarme:em amwme odlrooiwoeons uivppeowsne 001521 noewfmreS,E A PAapgpeen9 dix amt STaITT fespuenoesdstem= p0 -- 5aThose esc svioen SS5EnoyT we Ssmm% EB Er aEd o T5 cCEtgRSaemNeveErm new eUenRnEg uewmndoee TjWamotS lofobehiea SSSrHaEmEEsEmuRisno rTomhme i Sahmorw iuhmaeenns 001522 In PCFrSAoipPmaoeriomOycppuvaaAnisSrOsHEM AppendiHx Page 10 " go a 3a ", iy [ =. EET 259 a 35 STWRwou ad ea In PFS=S17udU3mn8oma2rat+oi0rl.F0yt4o820YpRSCmHEM RoRRoqqtuuunMeeetAnqSquare Bor 00270702318004565160 ObMseearvnaotfiRoenspoornSseumWis) "230a5o ESVoruiroocle oF| A"Snum2soo1fS2Vya0ar0ua7msnca Mem1S2w1w2o0 a 30472555 OBIS aPFisaomeor Croat a 25oue "oon TIYonRemSrCtHEM oAEouTmniEa OPaSrEaInmeotrer Gai[(mPaat9olso 09s 43 cSPoooobooilll rLOoowoewrmossSx GeUpoeperssrss 001523 melsral nesanso I' | . tL + | oepelndi&x TT or T RfIsonmsPe 0u-- 4nBa5ors5vmsc8reSonuseizs S S ReeT mabe rwea SSoon2 SEGsooomrwe or 8a sCisUdtSRTvAmEiRRr name i owemnn ocScaoueoe fTaam s COoSBsoIemEre wSEaHumEEanNnERarET1nR bommyMe wSlegEmLnE uoUmpuossn 001524 JCrraaePmaenimcptsuinysa,iWoE 1 | Je | . 5 = afer Te wor Feet Appendix In PRO=SSJ 008A00d2268fYRsm crEM [RRrouetrseieaog Newof Regis oSYoooimcsmiorsmye ey Cheatin orm Wig) A fsiauoce or: A"nUoRfp aVSaaRsn twey msum Fra Coat Ee es TTsanm he dmEorm6mia dSPaouanrmosotr EsUnmRhSe baob ome Tol ones LSaoweresssnx opppoernessn 001525 1 res mm __InBMyYSAS7 CHE0M ppm 1 2 1] 5 - Ts ~ OR re 5Di, rine Sooe oe eEEeE LL i. rt EEE wer om AppendiHx Page 13 001526 ner earogonSnen - | AppendiHx Page 14 IF * Zi i, : sod, Lo In wo ~ : NEFnnkrea-- BNRosqtaeai re Orme oSsSomteraeennnn " osreo MUgRoraRrvncInss eMnem eGnme fBToamcehi oSCnoammEne RGSpSmuErEs1TDesROrdoTmt aaommmoeess uoupmnoen 001527 7| :IGnraAmpiioMcPmaarlBiOScypiepYraaAn5ttSosrCsH6EM 1 i Lo. tt || AppendiHx Page 15 2:00 0. 5 , Sn 8 a8 ax wo SoMuodrecle ECmoral TInormcept YRSCHEM In MSS6dfpp=mS2Lu7i8nm9ema1ra-oFfri0.Fy0i3t042 YRSCHEM RRSSqquuirree Ad Root Mean Square Error 0000643s327658 1070608 MObesaenrovfiRoenssp(oonrseSum Wats) 3.102648 OF1 ASnuamolfofSyVuasarimiasnsce 4808428 Mem4S8a0u8w5e3 aFlroaiso &@ 7715086742456986 11620 P0r0o4b4o8r 2E7st0im5a7te 0PS2aWr0aE0mMe8tr6erEsti3(mFa7atle2es P<uobmll Loaweorss% 003415 00S 205 00s "00601 oUpapesresssw Oooo 001528 ero[drermnseson EE : pl 1 LH fi . am pep : wa AppendiHx Page16 RsIquenp=r-- 15n5Oa73a{nSBostsvoascrmmontzs fRNooostages Choate Sum Wit SpSieemodsn 1 SFsoooe Tow o3r: [ ERSL-- iE mam ne owe fhroeee nes Toe THToommess OdcIoamGeme PSoSamoEnmoEenaSs sims TSha oTomyRe ocmwoiemmss uoeroeess 001529 rate (oisemBy vRSCHEM wm 2 rx xd wo fPBose OE retJsht atesve, scrmJ obnezas RSoesrs ven oa7 F=e oon o etmy TtsemaRstes i Lan VoumlE mSbeannw aa-- ImeEes -- SUECRha mcam Sehemn TuEEeS 001530 ayopopacee : i i128 a si er Kal AppendiHx AN L . F araR raar rar InPOARegm sue 5 Sc0o8eSrupe vec ores ERTotoeumSe meteen Sofanresiss u y5Czome Sa o4r[sSMmEmmiSEttmSe E00 ple duesmmaen arceoee pro rjHoumll CScuomrhsae oCS-- EhEESmS a eeraom onlomisos uwuppsoan 001531 In PESAEpraesormcByta:RsSCHEM [me 1 . || Appendix Page19 3[3 I PY ------ : =n I Tnwan was EVSCroouorrcae VyIRonsmcehtEm near RRsoInqqPuFurOeeSAAAldfppm Roo Mea Square Sana = -5.5422 - 0.00745 Emr YRSCHEM oLco"as0u0stss Cfhurevaoon mor SumWat) Fr5 Anctavariasnce O55F%| SumPGorfoaeSqveuairse)s ollos Mean Square FpeooRsiaotoerio DsoFwmiiumsmoi oSPauwrtmaertsaer etmMltaeeilsa oo oss Poasoosono Looowomemres U"spPpeeemaress 001532 ner htore - | Fey AppendiHx EEfIe er] ELE : TIwoES RsRquIrnegia 3e8o8ur r5ssvaseoSaatrs RNeomotReeemwora SDieor=s Stasoetre o3rTOeSCsUTNtvLEeiERmrEe eweeinm oUeeamo Toa BBW oe TSRomSeS CSCwoemmwme S[diomEm--E--UDoatTvcEohnet ogowbnmos uovppwwmoeon 001533 AElnPganrotocrptaantns aT TInPt FOSApom.By YRSCHET M = l oq - Ef Bop frm mf - an HAE CAERCC ERE ws AppendiHx Page 21 ESMroooudrrecle CTou TInoemreept YRSCHEM In PFOSAdipp=m-5Un3o6a8r8Fi+t0.0086 YRSCHEM RSqure `SummaofrFyit RquareAdj 0000025330482 RMoeoatnMoefaRneSsqpuonasree Err 15S832n97 Observations (or Sum Wets) 3 AnalofyVasriiansce 3O5F1 Sum o7f0.S47q73u19a10r81e76s Mean20S54q01ua61r89e PF0r.Roaw8tei%Fo 36 88210203 06673 SEEstiSmaSte SPaGrEammtrerEstim(aRtaelso Probl 0394 a6) <00l L6o6we0r7S65)% OOORSOSI 001932 043 06673 0031663 aUoppseerosrssw 004fass 001534 In --55p8AEtpgarnBcmaypannisYASGHEM 1 | Appendix Page22 Fo ES f4i,n . Two8s ns ESMmooeuord Clow YiTRnoSmeCpHtEM InMS56dom =S4u7G3imn6e8ma+raFortf0F0y0i765 RsRRoqqouutarMreeeaAndjSquare Er OMbasenrvoaftiRoensspo(nosrSeum Wye) ori A"Snm0e3olf7sSv3aa0rmi3eamnce H3 sS0o2s1i3s0i3ss SEs7in6ss 0Pa3SraE6mmestrerEstis(mPaetaelsso 0076503 00105 0S YRSCHEM L00i00s02s70i39s7 Sisise5s Me0mLs3w%sw:e PoFrarsoueitse 0813s Pc0uo6bnl1ti Laoawuaernns UcTpopemoariowns 001535 APapgpeend1ix 1 Appendix I Regression of regression Random sample luorochemical on cguernrdeenrt,joyebacrshewmoirckaledopienrcahteormsic(anl=a4n7d):age: followed equationoffluorochemical on gender and years worked in chemical: by 001536 MSooudrecle. ErCrToorul `GRhoamnidcaolmOSpaarmaptloers SIun mPmFaOrSy pofoFmit RRSSqquuaarree Adj RMoeoatnoMfeRaenspSqounasree Error Observations (or Sum Wats) OF AnSaluymsoisfSofquVaarrieasnce a3 128020402200719 Pa 16262370 000.16213917583 00359725752050 a Mea0n6S6q6u7a6r6e 033211 SLoaucrkcoef Fit: TPuorle EErrrroorr 0Ma9x7R9Sq OF LSaucmkooffSqFiutares MoanSquare a2 10339311804253 0031369529724 a 14242071 TIontemrcept `GYERNSDCEHR(EFM-M] AGE ParamEosttoirmsElsotimatesSWEmor tRaio 00464337 020812 00.411022484828 200.121 0000002992683841 0000100891194 008257 GSoEuNrcDeE.R AYGRESCHEM Neam DF EffectSuTomsotfSquams |" 13553627 4F0R9a2l1o LLo oa 002032948865027 0070274520 20R1at3i1o Probar 0.1263 20R4at4i8o ProboF 03833 P0r91o0b9 0030949953 07855 0P0r4ob9s3F 00738959s5 APapgpeen2dix 3 001537 MSooudrecle ErCrToorul LSaocurkcoef.Fit TPoutrael EErrrroorr 0M8a1x2R2Sq ITnotemrcept GYERNSDCEHRE(FM-M] GSEouNrDceE.R YRSCHEM ChReamincdaolmOSpearmaptloers SIun mPmFaOrSy pofpFmit RRSsqquuaarree Adj MRoeoatnMoefaRnesSpqounasree Error `Observations (or Sum Wats) OF AnaSluymsiosfoSfqVuaarieasnce "2 141296765942418 % 16262370 OF LSaucmkooffSqFiutares 123 131025105998356 " 18266921 00..102811662937 00.359629742258 rl Mea0n9S8q7u7a2r4e 0324248 Mea0nS8qu1ar8e 0169499 3F.R0a4t6i2o P0r0o8b7>7F R2a5t4i50o P0r0o2b1F 0E1st2i7m0at5e 00021007999449 ParSatmdeEtmeorrEstimatteRsalo 001.081478923 210140 0008978 122 Npam DF Effect STuesmtofSquares [1 ET 0L48I22S50T6 P0r2o7b6l2 0020249711 4F1Ra7ti3o 1487 L0o1w2e6r3S8S7% 00040173104958 0P.r0ob7s1F 02201 APpapgeend3ix I Up0p4e3r197597% 00209.00403288 001538 ChReamnicdaolmOSpearmaptloers SoMoudrecle ErCrToorul `ISnuPmmFaHrSy pofpmFit RRSSqquuairree Adj MRoeoatnoMfeaRnesSpqounasree Error Observations (or Sum Wes) OF AnSaluymsiosloSfqVuaarieasnce a3 1143659406706530 46 28236813 040.4437493723 0~.L51874750085 a Mean4S5q1u5a3r5e 034165 SoLuacrkcoefFit PTuoruelErErrroorr 0M9a8x8R4Sq OaF LSaucmkooffSqFiuterss 14362568 Mea0n3S5q0u3a0r7e a2 104362980179653 0164098 TInotemrcept GYERNSDCEHR(EFM-M] AGE SGoEuNrcDeER Neam[a AYRGSECHEM LFoE ParamEesttoirmeElsetimatesSWEmor L03E47S84T7 004.118084994 00000407508063 0000110i908885 OF EffoctSuTomsotfSquaws 631748266139405 0009719 taRdaiso 343234 005 1F0r2ai2o 10709072985 1F32Ra1t6i5o P<r0o0b0o1F 2.R1a3t4i7o P0r3o7b0a7r P<r0o0b0slt 0000000118 0577 0P0r0ob1s8F 0009050717 PAapgpeen4dix I 001539 SMooudrecle ErCrToorul Lsaocukrcoef Fit PTuortealEErmroorr 0M8a9x3R3Sq TInoemrcept Y`RGESNCDEHRE(MF-M) SGoEuNrDceER YRSCHEM ChReamnidcoalmOSpaermaptloers Rsquare ISnuPmFHmSaopfrpFmyit RSRoqoutaMreeaAndjSquare Error OMbesaenrvoaftiRoenssp(oonrseSum Wes) OF ASnumaoiloSqyVuaasrrieiasncse pr2t 1143659315703758 pl 28236813 OF LSaucmkooifSqFiutares 2is 13.061737980332 Pl 14691735 LEsStimTate ParaSmUeElmoorrEstimaRtoas l 014029 1345 00O46767844 00.010032197 3S3172 Neam OFEftctSuTomsotfSquares 1 [ET 8377620005507 00.345769064966 0"5L7177874034 a Mea6nS7q7u5a4e 03330 Me0a4n4S9q1u4a7e 0167439 2R02a82o9 P<r0o0b0a1r R26a82o5 P0r0o1b7r0 P<r0o0b01l Lo2wiorrdS0S14% <0000001l6 000525863016226 13FR4a1tl8o oPorooblssF 26210 <0001 PAapgpeen5 di1x Uppeeorraessu 006.s309n6e9s9 001540 ChReamnicdaolmOpSearmaptlores. MSoodurecle Error CToul `ISnuPmmOaArAy pofpFmit RRSSqquuaarree Adj MRoeoatnMoefaRnesSpqounasree Error Observations (or Sum Weis) OF `AnSaulmysoifsSofquVaarrieasnce a3 135.061838985896 Pa 18702845 0.197237 0.05.9104819293 0635094 Fd Mean1S2q9u6w3e 034916 SLoaucrkcoef Fit PTuoruelEErrrmoorr M09a9x5R0Sq OF LSaucmkooifSqFiutares MeanSquare a2 104099149272318 00034673L8IL9 "a 15013059 TIontrerncept GYERNSDCEHRE(FM-M) AGE ParamEestteirmeElsotimatesSiWEmor tRato 003331988390331 00.41205367373 300810 0000000383%993 0000111120086 080 003 GSEouNrDceER YRSCHEM AGE Noam DF EffoctSuTomsotfSquares FRaio L[oI 0321270063851675 90799 06320 [I 00003258 00009 3F5R2a1i7 P0r0o2n28k 7F.R72a4i3o P0r.o1b21a1r P0r.4o2s6i6 00.04034130 09758 0P0r0ob4s3F 0094735180 APpapgeend6ix I 001541 MSoodurecle. Error CToul SLoaucrkcoefFit TPoutraelEErrrroorr 0M8a7x5R8Sq ITnotemrcept GYERNSDCEHRE(FM-M] SGoEuNrDceER YRSCHEM `CRheamnidcaolmOSpoarmaptloers `ISnuPmmOarAy pofpFmit RRSSqquuaarree Adj RMoeoatnMoefaRneSsqpuoanrsee Error Observations (or Sum Wats) OF AnSaluymsoisfSofquVaarrieasnce a2 135.061848256805 4% 18702845 OF LSaucmkooffSFqituaes 26is 122362912936159 a" 15014285 00.119670271209 00653854019542 a Mean1S84q4u2a8e 034123 Mea0n4S8q8u1a6r6e 0.128998 sRaatoio P0r.o0b0s8F0 R3a7t84i3o P0r0o0b2o5F 03E5s0m6a1l6o 00030198029833 ParaSmUoEtfoorrEstima(tReastio 00.11044202653 320458 000921 099 Neam1DF EffoctSuTomsotfSquaies 31700833 [-- 03330469 0P0ro1b7s1l 0030208369 9F2R9a0i1o 09760 0L0ow6s5r7SS2% 00050298476337 0P0r0ob3s9F 03286 APpapgeend7ix I UpOpeearsoarsoxs 000130776863190 001542 SMooudrecle ErCrToorul ChReamnicdaolmOpSearmaptloras. ISn uPmFmOaSrAyAofpFpitm RRSSqquuaarree Adj RMoeoatnoMfeRaenspSqounasree Error Observations (or Sum Wes) OF AnaSluymsoisfSofquVaarrieasnce 83 10161.1026069057 Pa 117.18701 00003914755939 1.45470853568 a Moan3S7q0u6a9r8e 246665 SoLaucrkcoef.Fit PuTortealErErrroorr 0M9a2x9R7Sq OaF SLuamcokfoSfqFuitares 9782374 Mean2S3q8u5a9r4e a2 1068.2046263037 41216 TInotemrcept Y`GRESNCDEHRE(MF-M) AGE ParamEestiemraEtsetimatesStEmor tate S0I44S1I567T5 0L21820S7S663S 1S5u7l 00003252473635 00002299572855 41129 GSEouNrDceER AYRGSECHEM Neam[a OF EffectSuTomsotfSquaes 61015043 2F4r7a3o LJ o 355020163231416 2L0402966 15R0at2i8o P0r2o2b7s4F F0E 5R7at8i9o P0r5o0b9o5F r<o00b0sl 00..621351 02387 0P.r2ob3o1F 0o.2l36l7s APpapgeend8ix I 001543 SMooudrecle ErCrToorul SoLaucrkcoefFit TPoutraelEErrrroorr 0M.a6x36R6Sq TInotemrcept GENDER(F-M), 'YRSCHEM SGoEurNcDeER YRSCHEM ChReamnicdaolmOSpaermaptloers I`nSPuFmmOaSrAyAofpFpitm RRSSqquuaarree Adj MRoeoatnoMfeRaensSpqounasree: Error Observations (or Sum Wgts) DF AnSaluymsiosfoSfqVuaraieansce. a2 1079.3589794601 P 178701 OF SLuacmkooffSFiqtuas 123 46265999070346 a" 10958740 0002026344835 Ls"7a8a187316 a Mea3n7S9q9u8a1e 249062 Mean2S5q7u6a8r2e 236611 1F5R2a5t6o ProbaF 02288 F1E.R0a8t9i1o P0r.o4b33s5F 44Es8t6i6ma3t7e 0439541 0022657 ParSadmEemteorrEstima(tResao 0023832810149 1S16e9 0024883 091 Npam OF EffectSuTomsotfSquaes 1[a a 2600644596343059 P<r0o0b0ll 0031627654 2F4R2a7l4o 0891 5L2o6we0r1S4s1% 0L0o7o288I036 0P.r1o2b6o4F 03675 APpapgeen9dix I 3Up1pe3r3sssw 000.217249931068 001544 `CRhaemnidcoalmOpSearmaptolras. MSoodurecle. Error CToul SInuMmS7m0aporpfFmyit RRSSqquuaarreeAdj MeRoaont oMefaRensSpoqnusaer.e Error Observations (or Sum Wes) OF ASnumaofloSfqyVuasarriieanssce a3 5287.03545557873 46 61060161 00..017366682412 1.107108 203122 a Mean2S7q8u5a1r9e 122569 Source Lack of Fit PTuoruelEErrrroorr Ma05x92Sq OF LaScukmooffSFqiutares 41 2 52472382 0232195 "a 52704577 MeanSquae 127981 011610 ITnotemrcept YGRENSDCEHRE(FM-M] AGE ParamEestteirmEastteimatesSWEror tRatio 1709276 0793426 029462 0.1914 205 149 0000031875588 00002200891926 1-08038 SGoEurNcDeER YRSCHEM AGE Noam OF EffectSTuomstofSquas FRaio JrEo 4207010693559015 323231727 roa 00087486 0.0071 R2a2t72i0o ProboF 00937 FRatio 11.0236 ProbsF 0.0865 0Pr0o3bs7i4y 00.01744379 09331 P0r1o4o3f 00747 09331 Appendi1x Page 10 001545 MSooudrecle. ErCrToorul LSaocukrcoefFit PTuoruelEErrrroorr 0M7a1x3f2iSq TInotemrcept GYERNSDCEHRE(FM-M] `SoGuErNcDeER 'YRSCHEM ChReamnicdaolmOSpaermaptloers `SInumMm5a7r0y pofpmFit RRSsaquuairree Adj MRoeoatnoMfeRaenspSqounasree Error Observations (or Sum Wets) OF AnaSluymsoisfSofquVaarrieasnce a"2 582374163833256 a6 61060161 2O6F LSaucmkooffSqFiutares 35199258 a1"8 5127751134302668 00..019376465989 12.00391452426 a Moa4nSq2uwe 11903 Moan1S3q5u3a8r2e 097300 sFRaatsio P0r0o3b9a4r F1R3a9t1i4o P0r2o3b6o5F L7Es6t7i3m3sl1e 0020934973343 NeamTo ro ParaSmWoEtmoorrEstima(tResao 00129656616859 664 LSI 00ITS8 228 DOF EffoctSuTemsotlSquaes 6227616802704 P<r0ob0s0fll 0010329715 2F2Ra6l0o 5197 2L3ow0e3r739s7% 00.067849102658 0P.r3ob9s1F 0027s APpapgeend11ix I 1Up3p3o0rg6s4w 000090946306133 001546 ChReamnicdaolmOSpaermaptloers MSoodurecle. ECrToorul S10uPmmFaOrSyAopfpFmit RRSsqquuaarree Ad) MRoeoatnoMfeRaenspSqounasree Error Observations (or Sum Wes) OF AnSaluymsiosfoSfqVuaarieasnce a3 1469.0265166597 Ea 15531826 000.4002268627 1861868 3.5716a7 Mea2nS0q8u5a2e 346655 SoLaucrkcoef.Fit PTuortaelErErrroorr 0M9a7x6R3Sq OF SLuacmkooffSFiqtuas MeanSquwe a 2 14538604 3.67565 354600 183782 a 149.06169 ITnotemrcept GYENRDSECRH(EFM-M] AGE ParamEestteirmaEtsetimatesSUEWor Ratio 02169978198015 1033342387 025092 0023905 001721 000305303011 004698 GSoEuNrcDeE.R YRSCHEM AGE Noam OF EffetSTuomstofSquas FRaio I [a L1S2B186S66264)5 0043558130 io 08381204 02418 0F 6R0at1i6o Prob>F 06175 1F 9Ra2t9i5o P0r.4o0b0F6 0Pr0o4bs9i4y 05567 005205240 0P5r5ob6s7F 0065205240 APapgpeend1i2x I 001547 MSooduercle. CErrToorul SoLaucrkcoefFit TPoutraelEErrrroorr 0M.a5x68R6Sq InTteormcept GYERNSDCEHRE(FM-M) GSEouNrDceER YRSCHEM `CRheamnidcaolmOSpaermaptloers Rsquire ISnuPmFmaOrSyAopfoFmit RRoSoqtuaMreeaAndjSquare Error OMbesaernvoaftRieosnpso(norseSum Wes) OF AnaSluymsoisfSofquVaarrieasnce a"2 1495..8491988415 P 15531826 OF SLuamcokfoSfqFuitarss 123 6872.8090184383 a" 149.8981 000.3040888968 3185475176576 a Mea2nS7q0u2a3e 340681 Mean3S1q8u8a1r3e 37268 oRatsio ProbsF 04579 0F8R5at6i4o P0r6o4v8osr Fsimate ParamSeGtEemrorEstima(tResao O3I391B6I0T734 0034294985838 076309 003353 0029102 LIS Npam OFEtoctSuTomsotfSquaes [La oa 4L528581603 P<r0o00bll 00255122 0F3r60a7o 13293 L4o2w2e0r192s8% 00.806932124058 0P5r5ob1o2F 0252 APpapgeend1i3x 1 aUprpiesrsessw O004265e0s9o8l7s 001548 MSoodurecle. ErCrToorul LSaocukrcoefFit TPuoruelEErrrroorr 0M9a9x7S3 q `ChRoamnnidcoalmOSpaermaptloers S0umMm5a5r5ypofomFit RRSqquuiarree Adj MRoeoatnMoefaRnesSpqounasree Error Observations (or Sum Weis) OF AnaSluymsoisfSoqfuVaarreansca a3 27..867933036855 kg 60566451 OF SLuamcokfoSfqFuitires a 2 520.711603002378 a 52873065 00.016267101294 31..11028285736 a Mea2nS5q6u4a6o 122961 Moan1S2q8u5a6r1e 00812 TIontrerncept GYERNSDCEHR(EFM-M) AGE ParamEostioirmeElsotimatesSWEmor tRaio 02374607989782 007.9149689243 137512 0000034143214 0000220180436 102419 SGouErNcDeE.R AYRGSECHEM Noam OF EfoctSuTomsotfSquaies (-- 36385764 2F9R9ai1o LFoE 027025556367390 0202415607 2F0R8at5i6o P0r1o1b6a2r 15F 7Ra7t0i7o P0r0o6b1a3r P0r0o0blll 0010493286 08329 0P0ro9bo6F 00.81342398 PAapgpeend1i4x 1 001549 MSooudrecle CErTroorut Source PLuarcekoErfrFoirt TMoatxalREsrqror 07329 TInotmercept YGERNSDCEHRE(FM-M] SGoEuNrcDeER YRSCHEM `CRheamnidcaolmOSpaermaptloers SIunmMm5a5r6ypofpmFit RRSSqquuaarree:Adj RMoeoatnoMfeaRnesSpqounaser:e Error `Observations (or Sum Wats) OF AnaSluymsoisfSofquVaarrieasnce 2 7.638006 44 4 6502596268445415 OF LSaucmkooffSFqituaes 1286 36751620 16.176825 a" 52928445 0.00.8162361817 13..01926275737 a Mean3S8a1u9a0r0e 120292 Mean1S4q1u3a5r2e 089871 F3.R1a7t4i8o ProboF 00515 F1.R5a7t2i8o Prob>F 0.1616 29Es4t6i5ma1t7e 0341253 003379 ParSaWmEemteorrEstima{tReastio 0266731 0.196063 1.05 174 0017293 -195 Npam DF Effect Tost SumofSquares rro oa 4356944217536050 <Pr0o0b0sl1i 0000587818 3.F0R2a0o4 38180 3L4ow8o4r09757% 007036683622 0P.r0o8b8s8F 00571 Appendix I Page 15 U2p.4p0e89r5s7 0000051308681572 001550 PAapgpeen1dix J Appendix | Regression of Random sample fluorochemical on current job engineer/lab gender, years worked in group (n = 23): chemical and age; followed by regression equationoffluorochemical on gender and years worked in chemical: 001551 MSooudrecel. ErCrToorul SoLaucrkcoefFit PuTortealErErrroorr 0M9a8x1R0Sq InTteormcept YGRENSDCEHRE(FM-M) AGE GSEouNrDceER AYRGSECHEM RaEnngdionmeeSriaLmapble SIunmPmFaOrSy pofoFmit RRSsqquuairree Adj MRoeoatnMoefRaenspSoqunasree Error Observations (or Sum Wets) OF AnaSluymsiosfoSfqVuaarieasnce 13 194.310897338110 2 23496691 OF SLuamckofofSqFiut aes 131 013.3484662671683 19 14309381 002.30941804074 0089637889288 23 Mea3n0S6q2u4a4e 075313 Mea0n7S7qu0a5r8e 0446618 R4.a0t6i6o3 P0r0o2b1s7F 1F 7Ra2t4i4o P0r5o4b3s8F PAappgeend2ix J DE6sIti6m8el6o 0(004S6671563626 O03 Neam[a [IoI ParaSmGeEtweorrEstimaRteas.l 01241345705847 026423 00004378643237 016252 OF EffectSTuomstofSuats 511154186508007 03226016 P0ro6b7ol2l 002031806 05206 6F8R4al0l3o 0144288083 3Lo6we0r4SS7% 01003131617458 0.30872 0P0r1ob7s0F 0052230866 Upp2aosresorsrss 0-.02M7l128i0s0s 00685214 001552 MSooduercle ErCrToorul LSaocurkcoefFit: TPoutraelEErrrroorr 0M8a4x1R8Sq ITntoemrcept GYERNSDCEHRE(FM-M] SGoEuNrcDeE.R YRSCHEM RaEnngdionmaoSraLmapble SIunmPmFaOrSy pofpFmit RsRqSquuaarree Adj RMoeoatnMofeRaenspSqounasree Error Observations (or Sum Wgts) OF AnaSluymsiosfoSfqVuaraieasnce 220 184.683614978038 2 23496691 OF LSaucmkooffSFqituaes E2l 103971183276157 2 14631983 LSEsItBiEmsIl9o 000523373737714 ParaSmUeEtmoorrEstimaRtaetsio 00220781538728 2S5687 0013818 169 Noam DF EffoctSuTomsotfSquates [{I -- 4280683616675358 0377275 00835155303062 0.93898 5 Mean4S4q3u2a3r5e 073160 Mea0n5S0q9u4a7r6e 0464783 P<r0o0b0sll 0010016880 6F6R4a7i3o 2822 R6a0t58i4o ProboF 0.0088 1.R9a5t6i8o ProboF 0173s 2Lo1w0e4r9659% 00.907025846857 0P0r1ob8s0F 0.1068 APapgpeend3ix J 0Up0pe1r2os0w 000.15022166813 001553 MSooduerlce ErCrToorul LSaocukrcoef.Fit TPoutraelEErrrmoorr 0M9a8x4R9Sq ITnotemrcept YGERNSDCEHRE(MF-M) AGE GSEouNrDceER YARGSECHEM RaEnngdionmaoSraLmapble Rsquare SIunmPmHarSy pofpFmit RRoSoqtuaMreeaAnQ)Square Error OMbesaenrvoaftRieosnpso(norseSum Wats) OF AnSaluymsoisfSofquVaarrieasnce 13 2116932763497106 2 38.300386 OF SLuamcokfoSfqFuitares 131 201537488045164 19 21926470 0043237751123 L2o574a722s1s 2 Mea5n4S5q7u9w7e LISO2 Moan1S18q6u0w2e 057806 4F7Ra0t5o 0P0r1ob2s5F 2F0R5at1i7o P0r.o5b0o60F 24Fo6i2m0a1l6e 000754416850059 0030306 ParaSmWeEtmeorrEstimattoRselo 0127675684377 217399 00005487956637 OLSIIS Neam[a OF EffectSTuomstofSquas 89859716 I Lo 013S02438352614s P0r1o8b1l7 002061478 0612 F77r8a6c6 0123628020 L6o.w1e8r098535% 10.209484290038 0.153717 P0r0o1b1a7r 0062163428 PApapgeend4ix J 1Uapepseirosrssw -00.115a4s2d0e0r7 009300 001554 SMooudrecle CEmoourr LSoaucrkcoefFit PuTorteal EErmroorr M08a5x4R3Sq TIontmercept YGERNSDCEHRE(MF-M) SoGuErNcDeER YRSCHEM RaEnngdionmeeSraimapnle RSquare ISnuPEmHmSaopofrmFyit 041955) RRoSoqtuaMreeaAngjSquare Error Meanof Response 01306514350080 250721 Observation (o Sum Wyts) 23 OF AnSaluymsoisfSoqfuVaarrieasnca MemSauare 2 16069059 s0Ms3 F72a28t0 22 3282.33010332866 LIST P0r0o04n3k IOiF LSaucmkooffSFqituies 18182976 Mean1S51q5u2i5e 2F9R9a4l3o 25 24203418332560 050604 P00r6o3b8 JEsIimeSlo ParaSmWeEtMeorrEstimatteRsaio 03ST ODE OOTOTSO 0002157700333 217897 Noam1OFEflotSuTomsotBfSqSuaBws roa 3899557 P<u0b0ls 0000729 7F8Ra1iso 3509 Lo4w0o%r39653% 0l0a0sss OProobisF 007s PAapgpeen5 diJx eUpspeorgssi 0o6serss 001555 SMooudrecle Error CToul SLoaucrkcoefFit PTuortaelEErrrroorr M0a9x45R3Sq TInotenrcept `GENDER(F-M] AYGRESCHEM GSEouNrcDeER YRSCHEM AGE RaEnndgnoemaSraimLpable `ISn uPOmAmAoaBfPrFMyit RRSSqquuaarree:Adj Root Mean Square Meanof Response Error Observations (or Sum Was) OF ASnumaofloSfqyVuasarriieasnsce 3 19 8.441730 17263008 2 25704738 OF LSaucmkooffSqFiutares 18 1 15.855759 1407248 19 17.263008 00232228347111 0953194 156794 2 MeanSquare 281391 090858 F3R.a0t9i7o0 P0r0o5b1s4F MeanSquare 018480072858 F0R6a2t6i0o ProbsF 07776 LEOstImaSle 0006362337312976 00271 Npam To ro r ParaSmWeEtmeorrEstima(tResao Ls76253 0235879 065 281 00004S2321097 006737 DF EffectSuTmesotfSquares 71953670 3 05318 03551409 Probal| 05252 00405311 0513 FRalo 7.9194 03868 03909 Lower3S% 4319296 0-0L5I6S040%72 0042213 ProbsF oil 04s3l 05393 PaAgppee6ndiJx Upperosw 22789001 00..1127006079199 00767938 001556 MSoodurecle. ErCtToorul SoLaucrkcoef.Fit PTuoruelEErrrroorr 0M.a5x98R4Sq TInotemrcept YGRESNCDHERE(MF-M) SGouErNcDeER 'YRSCHEM RaEnngdionmoaSriaLmapble SIunmPmOaArAy pofpFmit RRsSqquuuarree Adj MRoeoatnMoefaRnesSpqounasree Error Observations (or Sum Weis) OF An'alSyusmisolofSqVuaraieasnce 22 187068168519409 2 25704738 OF SLuamcokoifSFqiutares 2 3 125601025293135 20 17618149 00321446509555 019.3586579647 23 Mean4S0q4ua2r9e 08891 Mean1S2qu5a0r9e 032653 F45a89o9 P0r0ob2a9r F3R8at0i7o P0r0o3b2a6r PAapgpeend7ix J CELsOiTmaHlSo 00603087772674 ParSaimWeEtweorrEstima(tResao 00229278788759 267697 00ISI63 OSI Noam{--DF EftSuTomsotfSquaes 68604184 [E 02309580 P<r0o0b0sll 00601U432 7F7R8a7i5o 02622 2L6ow0e8r5S1S3% 0-0L2l368I6s56 0P0r1ob1s3F 0642 Up1peaersoissss 000.319631923918 001557 MSooudrecle Ermor C Toul SoLaucrkcoefFit TPoutraelEErrrroorr 0M9a9x9R7Sq ITnotemrcept `YGRESNDCEHRE(MF-M) AGE GSoEuNrcDeE.R AYRGSECHEM RaEnngdionmaeSraLmapble ISn uPmFmOaSrAyAofpFpitm RSRqSuquaarree Adj RMoeoatnMoefaRnesSpqounaser:e Error Observations (or Sum Wes) OF AnaSluymsiosloSfqVuaarieasnce It]3 3121283663671933 2 4.100406 DF SLuamckolofSFqiut aes 13 1 32.220887 0013726 19 32236613 0206.91051368 1.302561 520328 Mean3S9q5u4a6r0e 169666 Mean1S7qu9a0r6e 001373 23R3at0i8o P0r.o1b0s6F7 130F.R4a2t1i1o P0r.o06b8o8F 2IEs4t2i2ma7t8o O007606B5I6E57 0107688 NeamTo Lo ParaSmGeEtmeorrEstima(tResao 2013523393838 203999 00007517469757 L1S1I6 DF EffectSTuomstofSquas 2926797517567154 oa 3849343 P0ro3b3s2l4| 0020621703 01484 5F7R1at4i6o 13421 22688 6L.o6w5e0r5S8%6 10404553182% 0257327 r00o2b7s3 02610 014g APapgpeend8ix J 2U3p6p6o0r0s0s1w 00..1081955382 00419505 001558 SMooudrecle. Error C Toul SLoaucrkcoefFit PTuortaelErErrroorr 0M5a2x3R0Sq TIontmercept YGRENSDCEHRE[FM-M) GSoEuNrcDeE.R YRSCHEM RaEnngdionmeeSraLmapble RSquare InSuPmFmOaSrAyAofpFpitm RRoSoqtuaMreeaAndjSquare Error OMbesaenrvoaftiRoensspo(onrsSeum Wis) OF AnSaluymsoisfSofquVaarrieasnce 202 36800845494597 2 4.100406 1O2F SLuamcokoftSFqiutares 15048236 28 362.1008357975271 00..019891970352 153.423023482 2 Moan4S0q0ua2r2e L830 Mean1S2q5ua6r2e 26972 2F2R2a0i9o P0r.o1b34o6r F0E 4R7a6t9o P0r.o3b8s05k SSmRaMle ODeO0IMS NoamIo Lo ParSadmEemteorrEstima(tResal 003476516139 1221500 0021701 065 DF EffoctSuTomsotfSquaws 0779568020331880 P<r0o0bll 000542825 4F4R1a1l7e 0402 Lo6waeirsdasls% 010397313943 P0r0o4p8e6r os22 APpapgeen9dix J rUpeperraesw oooosmiiaeasy 001559 MSooudrecle ErCTroorul SoLaucrkcoef.Fit PToutraelEErrrroorr 0M9a9x4R6Sq TInotemrcept GENDER(F-M) AYRGSECHEM SGoEurNcDeE.R AYGRESCHEM RaEnngdionemarSiaLmapble RSquure SIunmMm5a7r0ypofpFmit RRoSoqtuaMreeaAndjSquare Error OMbesaenrvoaftRieosnpso(norseSum Wts) OF AnaSluymsoisfSofquVaarrieasnce It3 106785847092450 2 17641966 OF SLuamcokfoSfqFuitares 18 1 106079961174937 19 16887940 00.0140287441 0"934021671823 23 Moa0n2S5a1u3a4r2e 0888839 Mo0a9n3S2q8u7a8w 0096143 0F2R8a2i8o Probar 08m 9F 7R0al3i0o ProboF 02481 20Ed4i1ma2l4e 000027507057244 0033236 NeaTo [LIo ParaSmWeEtmoorrEstima(tReastio 0125539300326 017336 00005411774476 006642 DF EffoctSTuomstolSquas 003437822344666248 03666614 P0r1o9v1a0 00457496 05284 0F5R3a1i4o 00431820s5 LoSw3er7S7% 006056836727 0.141543 OP4rroabdF 005s2s8ds6 APpapgeend1i0x J 1U1p4p8e9r592s7s 003.118i321320678 00750014 001560 MSooudrecel. ErCrToorul SoLaucrkcoefFit PToutraelEErrrroorr 0M.a4x85R9Sq TIontmercept GYERNSDCERH[EFM-M] SGoEuNrcDeER YRSCHEM RaEnngdionmasSiiaLmapble Rquire SuInmMma5r7y0popf mFit RRoSoqtuaMreeaAngSquare Error MOebasenrvoaftRieosnspo(norseSum Wes) OF AnSaluymsoisfSofquVaarrieasnce 22 107328574630624 2 17641966 OF SLuamcokfoStqFuitares I]3 98..017804057293 Ed 17254602 000.2017955875 0390218681323 23 Mea0n1S9q%ua8r2e 0862730 Mean0S6q8u2a0r6e LISS 02R2a4o5 P0.r8o00b9F0 F06a01i6 P0r7o9b3o9F 3E0si9m6a8l5e 000104047680824 NoamLo [I ParaSmUeEtmeorrEstimatteRsa.lio 00222064560957 -1006S4I 0015006 005 DF EffectSuTomsotfSquaes 000305213681177459 P<r0ob0o0lIi 0095538065 0F4R0a7o6 00028 L3o7w1e1rsS752% 0.006310750138 0P5r3ob0s5F 09586 PApapgeend11ix J Uappmoarraesss 003023728078591 001561 MSooduercle ErCrToorul LSaoucrkcoef.Fit TPoutraelEErrrroorr 0M9a9x5R0Sq ITnotemrcept `YGRESNDCEHRE(MF-M) AGE SGoEuNrcDeE.R AYRGSECHEM RaEnngdnoemeSraLmapble SInumPmFaOrSyAopfpFimt RsRqSquuiarree Adj MRoeoatnoMefaRensSpoqnusaer.e Error Observations (or Sum Wets) OF AnSaluymsiosloSfqVuaraieasnce 3 1 0.846121 7.471423 2 73317544 DF SLuamcokfoSfqFuitares i]1 720130674305730 19 7471423 o0.o11414s5s3 5.13995332052 23 Mean0S2q8u2a0r6e 381429 Mea4n0S0q5u7a8e 036735 R0a0t73i9o P0r9o7b32e 10F 9Ra0t4i4o Probar 02345 SOEsBtSiImaEtTe O0I07060736327 0017139 ParSaWmEomtoorrEstima(tReastio 329618 0483297 18S 036 00100876149778 000126 Neam DF EffectSuTomsotfSquaos [LIJ o 000050900761505038513522533 0Pr0o7bs9l4l 007918907 08747 0F1R3a2l7o 000002064 1L2ow7e4r4s7s0% 0018837s6S2U 020725 0P7r1ob9s7F 009784470 APapgpeend1i2x J 0U7p7p4o4r5o9s8w 01Li7g9798378831 02413001 001562 SMooudrecle ErCrToorul SoLaucrkcoef Fit PTuortaelErErrororr 0M8a3x8R1Sq ITnotemrcept `'GEYNRDSECRH(EFM.M) GSEouNrDceER YRSCHEM RaEnngdionmaeSraLmapble Rsquare SInuPmFmaOrSyAopfoFimt RRoSoqtuaMreeaAndjSquare Error OMbesaenrvoaftRieosnpso(norseSum Wes) OF AnSaluymsoisfSoqfuVaarrieasnce 202 702.576488962105 2 73317544 OF SLuamcokoftSqFiut aes 2s 6101689771360290 2 72568929 000.1008281717 51..93094382458 3 Mea0n3S7q4u3a1e 362845 MeanSSOqSu8aIrLe 148395 F01a0l3c2o P0r9o0v2s5r F34a08t5 P0r0o4b5>2r SSiimomns |PaSradmEemteorrEstimaRtoaso 060M36E 906 OOOpLlLlLaIRSs | 0O0d3e0i7si764 0033%5 NoamTo DF EffectsuTomsotfSquaes 044622510 Lo 04730607 P<r0o0bo0ill 007m2e1s8 0F1R2al3l0o 01304 6L7o3ws9r0s6s8% oosmosss P0r7o2p0e5r 07218 PAapgpeend1i3x J Uipapievrems cjaoirmee 001563 MSoodurecle ErCrToorul LSaoucrkcoef.Fit PTuoruelEErrrroorr 0M9a9x9R1sq TInotemrcept YGERNSDCEHRE[MF-M] AGE SGoEuNrDceER AYGRESCHEM RaEnngdionmeeSraLmapble Rsquare SIunmMm5a5r6ypofpmFit RRoSoqtuaMreeanAdSyquare Error OMbesaernvoaftRieosnpso(norseSum Wats) OF AnSaluymsiosfoSfqVuaarieasnce 13 28L1i9678990168 2 20362824 OF LSaucmkooffSFqituaes 181 20.0725175515 19 28197906 000.319161793 14.26158023377 2 Mean0S3q8u8a3r1e 143410 MeanLSS6q5u1a2e 002575 R0a2t61i6o P0r8o5b2e1F 6R0a7t69i7o P0r.o1b00a6r SS3um4el3e 0D0u18k28m7 003428 Noam[a [[Ia ParSWaEmeter Estima(tReasbo 0200144686 024920 00006563896463 0O3SI4 OF EffoctSuTomsotfSquares 00126720558661498 038865284 P0u0b8l2 0073683 06147 F0.R176c9 002164199 L1ow0er0s605 0011351109 0105734 P0r.o6b78s7F 0067l34873 PApapgeend1i4x J Urppeosroesrs 0o0s9e4s6i1e5n6 o.17arees 001564 Source ErMrooderl C Toul LSaoucrkcoefFit TPoutraelEErrrroorr M0.a4x85R1sq InTtoermcept YGRESNCDEHRE(MF-M] GSoEuNrcDeER YRSCHEM RaEnngdionmerSiaLmapble SIunmMm5a5r6ypofpFmit RRSSqquuaarree Adj Root Mean Square MeanofResponse Error Observations (or Sum Wats) OF AnaSluymsiosfoSfqVuaarieasnce Ea2 280..578766525695 2 29362824 OF LSaucmkooffSFqituaes 2 3 13.4606 15.119953 20 28586559 0026437 1010975059425 4.65037 2 MeanSquae 038813 142933 Mean1S1q2u2a2r2e 188999 Ratio P0r2o7b1o5F 0.7650 R0.a5t9i3o8 ProboF 0.7996 48E3i2m3a6t4e 00050374013417 ParaSmGeEtmeorrEstima(tResao 00239719534158 1274 052 009315 038 Near OF EffectSuTomsotfSquares ron [E 0.39380354 021064617 Probl <0.060005I4 07051 0F2R7a5l5o 0.1474 Lower35% 5.623603 0007362181784 0P.r6o0b5o4F 0.7051 APapgpeen1di5x J Upporosw 04a0s4s1l1T226 0.047703 001565 APapgpeend1ix K Appendix K RegrersesgiroesnsoifonfelquAuolarltopicaohrnetmioicfciapfallnuotonrcuogrcerhneednmetircj,aoylbeoacnrhsegmweioncrdakelreodapneidrnacytheoaerrmssi(cwnaol=rak6n4e)dd:aignec;hfeomlilcoawled by 001566 Source ErMtoodrel CToul LSaocukrcoef Fit Pure Error MTaotxalRESrqror 09661 InTtoemrcept GENDER(F-M) AYGRESCHEM SGoEuNrDceER AYGRESCHEM CAhelmiPcaarltiOcpiepraanttsors ISnuPmFOmSaopfroFymit RRSSqquuaarree Adj MReoaont oMfeRaensSpqounasree Error Observations (or Sum Wes) OF ASnumaofloSfqyVuasariraienscse. 603 244.845030198614 6 29254145 OF LaScukmooffFSiqruaws 573 230896911563475 60 24853181 0.150430 0.107961 0643599 0.392284 64 MeanSquare 1.46699 041422 MeanSquare 0043138065293 FRatio P3r5o4o1f6 00198 R1a.2t6i6o4 ProboF 04953 Fsimate ParaSmWeEtmeorrEstima(tResa.o 0062633 JDasodes 0401961 010427 016 240 OO7II46 0000079 00001L0I609S82 0L0S1S Noam OF EffectSuTemsotfSquares ro ro 23900299 09933570 Loa 00000227 P0r8o7b6s7| 00.01129647 041 SF7Ra7ti0o 2030908011 L-o0w7e4r194508% 000.40549909325 0021478 0P.r0o1b9s4F 00.91924617 PAapgpeen2 dikx 0U8p6p6o6r7g4s3w 00-03.90241231943 00213193 001567 MSooudrecel. ErCrToorul LSaoucrkcoefFit TPoutraelEErrrroorr 0M6a9x1R8Sq ITnotemrcept `'GYERNDSECRH(EFM-M] GSoEuNrcDeE.R YRSCHEM CheAmlicPaarltiGcpiepraanttsors Rquire SInuPmFmOaSraylopfpFimt RRoSoqtuaMreeaAndjSquare Error OMbesaenrvoaftRieosnpso(norseSum Weis) OF AnaSluymsoisfSofquVaarrieasnce 612 244.845030290414 6 20254145 OF LSaucmkoolfSFqituaes 330 91.5081358012804 61 24853204 00..112520548348 00.633982320824 6 Mea2nS2q0u0a7e 040743 Mea0n5S1q0u9ar0e9 0300501 F5E.R4a0t0i9o ProbaF 0.0069 1F.R7a0t0i2o P0r.o0b74>8F 00E5s9ti8m2a4t8e 0020570056473 ParSaGmEemtoorrEstima(tReas.tio 0.132618 0.1088 045 244 0008912 192 Noam OF EffectSTuomstofSquas L[a oa 214491423963113 P0r6ob5s3l5| 0000610728 5F9r3Ra0i6o 36678 0L2ow0e5r39652% 00040506725635 0P0ro1b7o8F 00602 APapgpeend3ix K U0p3p3or5s0s1w 003-40084846882 001568 SoMoudrecle ECrmToorul SoLaucrkcoefFit TPoutraelEErrrroorr 0M9a8x4R2Sq TInotemrcept `YGRESNDCEHRE(MF-M] AGE SGoEuNrcDeE.R AYGRESCHEM ChaAmliPcaarliOcppearnattosrs. SIunmPmFaHrSy pofpFmit RRSsqquuaarree Adj Root Mean MoefaRneSsqpuoanrsee Error Observations (or Sum Wats) OF AnSaluymsiosfoSfqVuaarieasnce 3 2147869967961847 a 4259460 OF LSaucmkofofSqFiutares E 3 200627233355577 3 24896914 00431856429616 01..62434018645 6 Mea5n8S9q9u2w3e 041495 Mea0n4S2q4u9a7r5e 024452 1F42Ra1t6i8o P<r0o0b0o1F R1a.8t9i3o4 P0r3o3b5s3F -LEs7i2m0a8l2e 000347800823638 00ST ParaSmGeEtmoorrEstimatteRsalo 0014004331642 345258 0000U1I0O760I7 045344 Noam DF EffoctSuTomsotfSquaes F1 E 75283290380496 ro 01191450 P<roo0b0ll <000007 05940 12F6R2a6l6o 10828857110 L2o5w2e6r654% 00052959509031 0.027155 r0.o0b00s7 0<.05090410 APpapgeend4ix K 0U9pp1e7r1s4s4w 000176021058235 001568 001569 SMooudrecle ErCtToorul SLoaucrkcoef.Fit TPoutraelEErrrroorr M0.a5x06R8Sq TIontrenrcept YGERNSDCEHRE(FM-M) SGoEuNrDceER YRSCHEM CheAmliPcaarliGcippaarnattsors RSquure SIunmPmFaHrSypofpFmit RRoSoqtuaMreeaAnd)Square Error OMbesaenrvoaftRieosnpso(norseSum Wets) OF AnaSluymsoisfoSquVaarrieasnca ol2 2157051768055492 a 42594602 OF SLuamcokfofSqFiut aes 3301 186273805096909 61 25016059 00..349132463984 10..2634005349 6 Mea8n7S8q9u2a7e 041010 Mea0n5S4q1u4a8r4e 0274335 21F 4R3at2i1o Probar <0001 F1R.a9t7i38o P0r0o3b2o9F LEOsStiIm9at3e 0040435776554 PaSraWmEomtoorrEstimatteRsaio 00110333201572 1346457 0008941 499 Noam OF EftoctSuTomsotfSquaws [(E -- 15014955573367 r<o0b0s0I] <00000005 13F3Ra0i4o 248568 2L1ow9e0r2s4S7% 000528626899735 0P.r0o0b0o5F <0001 Appendix K Page 5 rUpepserossnw 00..016720415035 001570 MSooudrecle ECrTroul LSaocukrcoefFit TPoutraelEErrrroorr 0M9a8x0R7Sq InTtoermcept YGERNSDCEHRE(MF-M] AGE GSoEuNrcDeER AYRGSECHEM CheAmlicPaarltiOcpiepraanttsors `ISnuPmmOaArAy pofpFmit RSRqSuquaarree Adj MReoaont oMfeRaensSpqounasree Error Observations (or Sum Wats) OF AnSaluysmiosfofSuVaarriasnce 63 159..23124503597 6 24530453 OF SLuamcokfoSfqFuitares 57 3 180845713190570 60 19.325057 021249 00516m7i5l2s5 06145263 Mean1S7q3u8a1r3e 032208 Mea0n3S3q0u7a2r1e 0157986 5F.R3a9i6i5o Prob>F 0.0024 2F 0Ra9ti3o P03r0o0b9 04E3s7m0a6l37o O[0003I1S302S2215 0004228 ParaSmWeEtmeorrEstima(tResao 00039516944458 123 341 00000099473435 154 045 Near OF EffectSuTomsotfSquares ro oa 0377638738574097 roa 00647015 0Pr2o2b>2l4i 00.01021727 065% 11F.R6a0t53o 23856 02009 0L2ow7e1r9s3S9% 00.409074144832 0.023007 0P0r0ob1s2F 0.1277 06556 Appendix K Page 6 1Uplpaogr0csesrw 00.013240s340s7s 00146413 001571 SMooudrecle Error CToul SLoaucrkcofeFit TPoutraelErErrroorr Ma03x815R0iSq ITnotemrcept GYERNSDCEHR(EFM.M) GSEouNrDceER YRSCHEM ChAelmicPaarltOipceipraanttosrs ISnuPmOAmAaopfrpFmyit RRSSqquuairree Adj MeRoaont MoefRaensSpqounasree Error Observations (or Sum Wets) OF ASnumaofloSfqyVuaasrriiaenssce 612 1953.81949765985 8 24539453 OF LaScukmooffFSitquas 330 144584409338709 61 19389758 Cstmale ParamSoUtoErMEstimaRtaetsio 002381772349779 00019107817328 324495 002509 0007871 159 Neam OF EffetSTuomsotfSquaes 1 roa 038807778184 0209854 005.16833799457 0614523 6 MoanSquie 023517748865 Mea0n4Sq7u1ar2e 0ISI346 FRatio P8r.o1b0s0F8 0.0008 F3R.a1t6i5o ProboF 00011 P0r0ob1s7l1i L00o5wWo0r195%2 000107029 00.040939213016 1R20a99o7 P0r0o0b0o0F 25355 oun PAapgpeen7 diKx UOpspre1r4s8s0w6 00.0123s5d6s8s8 001572 MSooudrecle Eror CTout SLoaucrkcoefFit Pure Error MToatxalAEsrqror 05025 ITnoterrncept YGRESNDCEHRE(MF-M) AGE GSoEuNrcDeER AYGRESCHEM CheAmlicPaarltiOcpiepraanttsors RSquare I`nSPuFmmOaSrAyAofpFoitm RRoSoqtuaMreeaAndjSquare Error OMbesaenrvaoftiRoensspo(nosreS:um Wgts) OF AnSaluymsoisfSofquVaarrieasnce 63 15140.5635086052 6 165.1867 OF SLuamcokloSfqFuitares 531 134164.210458832 60 150.53065 00004838177325 14..52883699343 64 Mean4S8q8u6a0r1e 250884 Mean2S.q3u5a83r3e 536861 1F .R9a4t7i5o ProboF 01316 0F 4R3at9i3o ProboF 09106 52Es5i2m8a1l3e 00024132573 00265422 ParaSmWeEteorrEstima(tRosao 00295869264184 523013 00002267312989 116001 Near OF EffectSuTomsotfSquaes [ro ET 160432562222976 oa 2549914 P<r0o00b1l 0010144687 03174 4.F1R2a6l3o 2Lo5166144 TLo2ws3r6954% 0-L0093749s3T6s 0026121 r0.o0b46s7 00.31117448 AppendixK Page 8 3U2pp7e4r0s2s3w 000010078976545 00792083 001573 Source Model Ermor C Toul LSaocurkcoefFit ToPturaelEErrrroorr 0M5a8x5R8sq TInotemrcept YGRESNCDEHRE(MF-M) SGoEuNrcDeER YRSCHEM CheAmlicPaarltiOcpiepraanttsors RSquare ISnuPmFmOaSrAyAofpFpimt RRoSoqtuaMreeaAndjSquare Error MeanofResponse: Observations (or Sum Wats) OF AnaSluymsiosfoSfqVuaarisasnce 2 61 12.10810 15308056 6 165.18867 OF LSaucmkooffSFqituaes 3 30 84.6080 63.41976 6 15308056 43Es1t2i3ma0t4e 00042975506766 ParSaWmEeWteorrEstima(tResao 0329134 025533 -1310 194 002117 125 Noam DF EffectSuTomsotfSquares rLo oa 934.384978540416 0073299 01058823911456 4.28694 64 MeanSquare 605405 250952 MeanSquae 273099 228066 F24R1at2i4o ProboF 0.0981 1F.R1a9t7i5o ProboF 03117 Probsfi <0001 Lowor95% 497049 0002517714 0-0L70107S9624 3F7R5a9o r0.o0b57s1 15535 02174 APpapgeen9dix K Upper95% 030615544185810 00166594 001574 MSoodurecle ErCrToorul LSaocukrcoef Fit TPoutraelEErrrroorr 0M9a9x6A2Sq ITnotemrcept YGRESNCDEHRE(MF-M) AGE SGoEuNrcDeER AYGRSECHEM CheAlmliPcaarliOcppearnattsors `SInumMm5a7r0ypofpmFit RRSqquuiarree Adj RMoeoatnMoefaRneSsqpuoanrseeError Observations (or Sum Weis) OF AnSaluymsoisfSofquVaarrieasnce 3 7154483203609155 a 90253710 OF LSaucmkooffSqFiutares 573 705304864333596 75.430695 00..112624023397 1L94251644 6 Mea4n9S3q1u0a0e 125718 Mean1S3q1u7a2e7 01isss R39a30o2 P0r0o1b2s6F 1R1a4t0i2o 0P0r3ob3o5F laEsnti4mdat6e 0030330747769 0012926 ParSaUmEewtoorrEstima(tResat 00178010625732 117852 00001189623574 200619 Noam OF EffectSuTomsotfSquaes 1 FE 5401969100710793 Lo 06047597 P0r0o8b0l 00004780S 04906 3FR3a9ti8o 0440851600 2Lo6w2e3r9159% 0006797328839 0050205 0P0r7ob3s9F 00.40940865 PAappgeend1i0x K 0U1p7p8e3r0o6s5w 0-003.020802861s 00243593 001575 Source Model Error C Tol SLoaucrkcoefFit Pure Error TMoatxalRESrqror 0.5860 ITnotemrcept GENDER(F-M) YRSCHEM GSoEuNrDceE.R 'YRSCHEM CheAmlicPaarltiOcpiepraanttsors RSquare SIunmMm5a7r0y pofpmFit RSquare Adj Root Mean Square Error Mean of Response Observations (or Sum Wes) OF AnaSluymsoisfSofquVaarrieasnce 2 [1 14218255 76035455 6 90253710 OF SLuamcokfoSfqFuitares 31 38667300 30 6 37368155 6.035455 0.157537 0.129915 L166 1.94564 64 Mean Square 7.10913 124648 Mean Square 1.24733 124561 F Ratio 5.7033 Prov>F 0.0054 F Ratio 1.0014 Prob>F 0.4993 LE6sBtMmaTl4o 0343235 004655 Parameter Estimates 02S3W1E9M6o4r tRatio 724 0.179949 00ISSET 191 299" Nparm DF Effect Test Sum of Squares. J ro 4.534934 11117067 Probsf| <0001 00612 0.0041 F Ratio 3.6382 8.9187 Lower95% 2148315 0.703066 007719 Prob>F 0.0612 0.0041 APpapgeend11ix K Upper 95% 1216632 0.0165953 0015382 001576 MSooduercle. ErCrToorul SLoaucrkcofe Fit TPoutraelEErrrroorr 0M9a8x2R3Sq TInotemrcept YGERNSDCEHR(EFM-M] AGE SGoEuNrcDeE.R AYRGSECHEM CheAmlicPaarltiGcpiepraanttsors SInuPmFmaOrSyAopfoFimt RRSqquuiarree Adj MReoaont oMfeRaenspSqounasree Error Observations (or Sum Wes) OF AnSaluymsoisfSofquVaarrieasnce 3 21170988155336 & 219.0689 OF LSaucmkooftSqFiutares 57 3 2073.827093213 20108153 0000316147532 13887651674 6 Moan2S6q6u1a7r9e 350803 Mean3S6qu3a1r3e 129308 R0a7t5i66o p0r5ob2s9F F2E 8Ra1t1i2o P0r2o1b4o8r 3E0sti8ma2te O0018261 0013 Noam[a [[aI ParSadmEemteorrEstimatteRsalo 0L3I03T87A4 023693 0000331210786 004930 DF EftoctSuTomsotfSquaes 2085346568106907 06625603 0Pr0o1bs0i8| 00635718 06659 F0IRSScI 00.81086833 5L4ow2e6r79655% 00702973533417 007582 0P9ro5bs1F 0063675298 PAapgpeen1d2ixK 0U7pp4e0rnsessw 0004385851044669 00488320 001577 SoMuordecle. ErCrToorul SoLaucrkcoef.Fit TPoutraelEErrrroorr M09a8x2R3Sq TInotemrcept GYERNSDCEHRE(FM-M) AGE SGoEuNrDceER AYGRESCHEM `ChAelmiPcaarltiGcpiapraantlsors ISnuPmmFaOrSyAopfoFmi RsRqSuquaarree Adj MReooatnoMfeRaenspSqounasree Error Observations (or Sum Wes) OF AnSaluymsoisfSofquVaarrieasnce 63 21170988155336 & 219.0689 OF LSaucnkooflFSiqtuaws 57 3 207.2031 3.87923 3 21108153 0000316117532 31.887651671 6 Mean2S6q6u1a7r9e 351803 Mean3S6q3u5a1r3e 129308 R0a7t56i6o probsk 0529 2F8R1a1t2o p0r2o1b4o8F 30f8st3m5a5l2o 00012189261 0013 Nparm[a [LIo ParSaWmGeEtmeorrEstima(tResao 0L3I073I847Z44 023693 0000332U2T068 004530 OF EffectSuTomsotfSquares 2085346568106907 06625603 P0r0o1b0l8 0036195218 0665 0FIRsaStIo 00.81086833 L5o4w2e6r7s6s6% 0721531 000079538427 OPgroobssF 0063675398 APpapgeend1i3x K 0Urppaeornorssw ossides 000034535809926 001578 MSooduercle ErCrToorul SLoaucrkocefFit TPoutraelEErrrroorr 0M5a2x4R0Sq TInotemrcept GYERNSDCEHRE(FM-M) GSoEuNrDceER YRSCHEM CheAmliPcaarltiOcpiepraanttsors SInuPmFmaOrSyAopfpFmit RRSSqquuairree Adj MRoeoatnMoefaRneSsqpuoanrsee Error Observations (or Sum Wes) OF AnSaluymsoisfSofquVaarrieasnce 612 21177328248009 & 219.0668 3O1F LSaucmkooffSqFiutares 107.46461 6310 2110147247490498 00.000313743267 13886631172 6 Mea3n6S6q1u4w0e 347121 Mea3n4S6q6u6w0e 34758 R1a0t5i48o P0r3o5b4s5F R0a9t97i3o P0r5o0b3o7r 35Es6t2i9ma6t8e 0001337300549 NeamTo [I ParSaWmEemtoorrEstima(tResao 0033080720094 094240 0026012 42 DF EffectSTuomstofSuaes 706081S36T08 P<r0o0b0slf 0016559933 0F1R9a6i3o 2098 4Lo3w1e0r91S5% 000783037532 0P6r5ob9s3F 0.503 PAapgpeend1i4x K U3pp3eirssosrss 004061744935242 001579 `SMooudrecle Emo CTotal LSoaucrkcoefFit PTuoruelEErrrroorr 0M9a9x7R4Sq InTtoermcept YGERNSDCEHRE(FM-M) AGE SGoEuNrcDeER AYGRESCHEM CheAlmliPcaarltiOcpiepraanttsors RSquare `SInuMmm5a8r6ypofpmFit RRoSoqtuaMreeaAndjSquare Error Mean of Response Observations (or Sum Wats) OF AnSaluysmiosfo SVqauriaasnce 3 6 10282420 65590476 6 5.87289 OF LSaucmkooffSFqituaes 57 3 65396881 0.19359 6 65590476 00.019325259282 1.04555 "3.10248 6 MeanSquae 342747 L937 MeanLSIqAuaLo 006453 3F.R1a3t5i3o ProbsF 00319 F17R.a7t7i9o0 P0r0o1b7s7F 27Es6t5i8ma7t3e 000336063298 0006153 Npam [rIo [a PaSraWmEemteorrEstima(tResao 0653 016939 424 216 0017954 0017379 169 035 DF EffectSuTomsotfSquares 3S.211317681 0137028 Prob <o00l 0000935476 0.7245 4F6R7at5i7o 0218265532 Lower95% 4072068 00700656131014 0040916 0P.r0o3b4s6F 0070294557 AppendixK Page 15 Uppers 1.459679 0.027448 0005523 00286099 001580 MSoodurecle ErCrToorul SLoaucrkcoefFit TPoutraelEErrrroorr 0M6a1x9R9Sq ITnotemrcept YGRESNCDEHRE(MF-M) SGouErNcDeER YRSCHEM CheAmliPcaarliOcpiepraanttosrs. Rsquire SIunmMm5a5r5ypofoFmit RRSoqoutaMreeaAndjSquare Error OMbesaenrvoaftRieosnpso(norseSum Wits) OF AnSaluymsiosfoSfqVuaraieansce. 2 6l 6150712475530951 6 75872896 3O1F SLuamcokfoSfqFuitares 36884521 3610 6258782472590854 00..110353371136 130.3180204287 6 Mea5n0S7a2u1w0e LO7750 Mean1.S1q8u9w8e2 096143 4F 7R0at7i8o 0P0r1ob2s6F F1R.a2t3i76o P0r2o8b0s7F 29Es8i3ma9l8o 00023430921 Neam[a [E ParaSmUoElmoorrEstimattReaslio 00126175360678 -2123834 0014492 235 DF EffectsuTomsotfSquaes 55936649463313 P<ro0b0s0lll o002a98 4F9R5a3i1o 5536 L3o4w1esrl9sss% 00.0066390078 0P0r2o0b8F 0219 PAappgeend1i6x K Up3pSorroesew 000005317182 001581 APpapgeen1dix L Appendix L Regression equaAtlilopnaortfifcilpuaonrtocchuermreinctaljoobn engineer/lab group (n gender, years worked = 37) in chemical and age; followed by regression equation of fluorochemical chemical on gender and years worked in 001582 MSooduercle CETrroour l SoLaucrkcoefFit PTuortaelErErrroorr 0M9a8x7R8Sq ITnotemrcept YGERNSDCEHR(EFM-M) AGE GSEouNrDceER YARGSECHEM AlElngPianrteiecriipLaanbts `ISnuPmmFaOrSy pofpFmit RRSSqquuaarree Adj MRoeoatnoMfeRaenspSqounasree Error Observations (or Sum Wets) OF AnaSluymsiosfoSfqVuairieasnce n3 21.4417613768508 3 36635438 OF LSaucmkooffSFqituies 2 1 20.04546166128 3 2471780 00..338360681418 0089245023035 37 MeaanSqnuwe 06896 Mea0n6S8qu8a2r8e 0446618 F6R9a3lm P0r.o0b0a1r0 1F 5R4a11l P0r5o7b3o5F 20Es7t1i3ma4l2o 0004I3849246366 0046474 ParSaimGeEtmeorrEstima(tResao 0018655900128 226424 0000221664932 005857 Noam DFEffectSuTomsotfSquaes L[o It 046561692365779 Lo 02089349 P0r0o2b0l4 0003183338 05834 6F8R5at2i5o 0037066287 3L8ow0e1r0S3s5% 00072M581I8S8 0039152 0P0r1ob3o3F 00358888 Appendix L Page 2 U0papdeiresrssw 000069360775573 006844es 001583 MSooudrecle Ermor CToul LSaocurkcoefFit PureError TMoataxlRESrqror 07264 InTtoermcept GENDER[F-M] 'YRSCHEM SGoEuNrDceER YRSCHEM AlEngPairnteiscirpiaLnatbs. ISnuPmFOmSaopfrpFmyit RRSSqquuaarree:Adj MReoaont oMfeRaensSpqounasree:Error Observations (or Sum Wgts) OF ASnumaofloSfqyVuaasrriieasnsce 42 2123698504771253 3 36635438 OF SLuamocfkSoqFutitares 11s9 112060528161022 3 22680715 003.34840499018 081675 -094033 3 MeanSquare 606967770386 Me0a.n6S6q6u2a4r2e 0668141 1F0.Ra4t5i9o ProbsF 0.0003 F09R9at7i2o ProboF 05100 LEestilmaate 0439047 00293537 NeaFI [I ParaSmGeEtmerorEstima(teRsao 0012630998228 276782 0010721 274 OFEffectSuTmesotfSquares 47819718 SO008180 P<r0o00bIl 003 00098 7.F1R6a8o5 7.4966 L2o0w4e0r591s6% 0772296 00075663 0P0r1ob1o3F 0.0098 PAapgpeen3 diLx U-p11p3e99r0s6 0105797 00SII41 001584 MSoodurecle. ErCrToorul SLoaucrkcoefFit TPoutraelEErrrroorr M09a8x9R5Sq TInotemrcept YGRESNCDEHRE(MF-M) AGE SGoEurNcDeER A'GYRESCHEM EAnllgnPaerotircLiapabnts Rsquire `ISnumPmFaHrSy pofpFmit RRoSoqtuaMreeaAnjSquare Error OMbesaenrvoaftRieosnpso(norseSum Weis) OF AnSaluymsoisfSoqf uVaarrieansce. 33 2340562519787883 36 5.181656 OF LSaucmkoolfSFqituaes 32 1 300054738701586 5 30621774 00..340445602753 092653927953 37 Mean8S1q8u6a6r3e 092793 Mea0n9S3q8u8a6r6e 057806 8F 8R2at0i4o P0r.o0b0o02F F1R.a6i2i6o2 P0r5o6b1s6F AEiOmaSle 0C0O2S5666007S5S 0018228 Neam[a rLoo ParaSmWeEtmeorrEstima(tResao 00.919923464674 42912 00002350382618 016011 DF EffoctSuTomsotfSquaes 709924704197341 03487090 P0r0o0b0l2 000301622 0541 8F5R4al2o 013072578 6L0ow9s7r19257% 00906205096059 0043879 0P0r0o6b2o 0053414912 APpapgeend4ix L U5poSpooaessry 00.017712103445 00817245 001585 SVoEiudrnec!e Toa LSaocukrocreFi FVTuaorxlREEsrnoer os GTIEonNrmDeEepRt(EM) RSCHEM SGoERuNScDCeEHREM AEtnpaarniocrpiaanins Rsqure SIunmPmHaSpfoFm ors MRReoqontuoMaefeaARnedSsjqpounasree Er 003o304r347s049 Observations (or Sum Wats 3 oF2 ASnuamPolorrfyvSiaasrnimiassnsce MeanlSouswee a 30570483 05100 iPFrsroowisnor % Ss.s16s6 Soon OWFs LSaicmkoTtiSFaeqimms Mean2S0u5a1r5e F2r5i6o i3s [20r9a70r485 05813 rGeosr SEsiumme |PaorSaEmaevteonrrEstimaRlteeas xi Pcuobll O06 oie 299 om Laoweorsesk aoe OURS 00228 312 oan core NoamToOFCEtoctSTuomstosrsiwesms io SEs osForRamoloe OoProooovor Appendi1x, Page 5 TUppomrasn oermm 001586 Source Model Error C Toul SoLaucrkcoef Fit Pure Error Total Error 0M9a6x4R2Sq Torm Intercept GENDER(F-M] YRSCHEM AGE Source GENDER YRSCHEM AGE AElnlgPianretaicriipLaantbs, In POAA ppm RSquare. `Summary of Fit RoRSoqtuaMreeaAndjSquare Error MeanofResponse. Observations (or Sum Wats) OF AnaSluymsoisfSofquVaarrieasnce 3 3 12.006567 27333536 36 39.340103 OF Lack of Fit SumofSquares 2 1 25.926287 1.407248 33 27333536 0305199 0242035 0910104 "162112 37 Mean Square 4.00219 082829 MeanSquare 081020 1.40725 FRatio 4.8319 Prob>F 0.0068 FRatio 0.5757 Prob>F 0.8031 Estimate 2930403 0521939 0002985 00256936 ParSaWmEemteorrEstima(tReasll 0937648 0.182971 3.13 289 0023923 0.029164 0.12 088 Npamn DF EffectSTuomstof Squares To J 68958131 00129048 [I 06428967 Probslii 00037 00068 09014 03847 F Ratio 8.3254 00156 07762 Lower95% 4838141 0900194 0051658 003364 Prob>F 0.0068 09014 0.3847 Appendix L Page 6 Uppor 95% 1022846 0.155684 00456859 00850277 001587 Appendix L Page 7 SMooudrecle Error C Toul SoLaucrkcoefFit TPoutraelEErrrroorr 0M7a2x6R9Sq ITnotemrcept GYERNSDCEHRE(FM-M) GSoEuNrcDeER YRSCHEM AlElnPgairniocoiraLnatbs SIunmPmOaArAy pofpFmit RSRqSquuaarree Adj MeRoaontoMfeaRnesSpqounasree Error Observations (or Sum Wes) OF AnSaluymsoislSofquVaarrieasnce 32 21.1937663467312 36 39340103 OF SLuamckolofSFqiut ass 19 Is 1107724341592048 u 2.976432 0.288857 00920477100235 "Lez 37 Mean5S6q8ua1r8e 08228 Me0a.n9S0q6u9a43e 071632 6F 9R0a5i2o Probar 00030 F1R.a2t6i61o P0r3o2b4o9F ZEIsiTmaAlo 000I5S32672496 NeamTo [I ParSaImGeEtmoorrEstimaRteas o 00128231223431920974 00107 128 DF EffectSuTomsotfSquaes 7L133448589 P<r0o0b0ll] 002000882 8F6R7a1l1o0 Lets 2L6ow0e2r1S259% 00.900068490236 0P0ro0b5s8F 020m Ueppsesreossw 00-30.91467612715 001588 MSooudrecle Error CToul LSaocukrcoefFit PuTortealEErrrroorr M0a99x9R8Sq ITnotemrcept GENDER(F-M] YRSCHEM AGE SGoEuNrDceER YRSCHEM AGE AlEngPianroiecriipLaantbs InSPuFmOSmAaAorfpFpyimt RRSSqquuaarree:Adj RMoeoatnoMfeRaensSpqounasree Error Observations (or Sum Wets) OF ASnumaolloSfyqVausraisianscse 3 3 11836056 53456962 36 65293017 OF LSaucmkooffSFqutares 2 1 53443235 0013726 n 53.456962 0.181276 0.106847 15..26752672586 37 MeanSquare 394535 L6I9OL MeanSquae LET0I0 001373 2F4R3at5i5o ProboF 00822 12F1R.6a7i4o2 Prob 00717 Estimate ParSaWmEetmeorrEstima(teRsao O3S67711894393 1311276 025588 222830 00270165 0063657 0033456 0040785 081 156 Npam DF EffectSTuomsotfSquaes J Lo 80905950 10563257 [It 3546258 P0r0o0b8l4 00323 0.4251 0.1281 4F9R9at4i5o 0264532611 L-o6w3e4r5d7S27% 1092437 -004105 0.146634 r00o3b2s3 00.14228511 APapgpeen8 diLx U-p1p0olr0o1s3w8 -00Si26l 000.105935109893 001589 Source ErMroodrel C Toul LSaoucrkcoef.Fit PToutraelEErrrroorr 0M.a6x09R7Sq ITnotemrcept `YGRENSDCEHRE(FM-M] SGoEuNrcDeE.R YRSCHEM AEllngPairniccairpLaantbs Rquire ISnuPmFmOaSrAyAofpFpimt RRSoqoutaMreeaAndjSquare Error OMbesaernvoaftRieonsspo(norseSum Wets) OF AnaSluymsiosfoSfqVuaarieasnce u2 577..488093729270 3 65293017 OF SLuamcokfoSfqFuitares 1is9 3251.94281102946 3 7.403220 0.120837 010.26999132518 5.65628 3 Mea3nS9q4ua9e L683) MeanLS6qSuOaIrIe L697 2F3R3a6i6o ProboF 01120 0F 9R8at9i0o P0r5o1b6o6F APpapgeendix L EE6s0tm6at6e 0OS0S8L2I2S58 ParaSmUeEtmoorrEstimatteRasllo 00323620984717 1271010 0017056 LOT Nam OF EffoctSuTomsotfSquaes 1 [I 7159325708404460 P<r0o0b0Il 0020942280 4FdRsallso 11418 L6o.w3s3r698s79% 108121 0052886 0P0r4ob2s0F 02928 Upopegrasgessw 0020995 0oloass 001590 Source ErMroodrel CToul LSaocukrcoefFit PTuortaelErErrroorr 0M9a9x7R1Sq InTtoemrcept YGRESNDCEHRE(MF-M] AGE GSEouNrDceER AYGRESCHEM AEnlgPianreteirciiLpaanbts RSquare: ISnuMm57m0paopfrmFyit RRoSoqtuaMreeaAndjSquare Error MObesaenrvoaftRieosnpso(norseSum Wyts) OF AnaSluymsoisfSofquVaarrieasnce 33 320374697560338 36 BTA OF SLumaofocSfqFkiutares 32 1 32253360 0096143 32349503 2F4s8i2ma5l7e 0125208 0O00004I7S33678 Noam F[Ea ro ParaSmWeEtmeOrrEstima(tResa.o 0.L1O9X90563 304613 00.003216702276 001056 OF EflectSTuemsotfSquares 000308374816941017 002185078 0023179 02.090960506925 "3.19558 37 Mea0n2S5q5u8a7r9e 0980288 MeanSquare 0L0O9O69124 R0a2t6i1o0 ProboF 08529 F10R4a8t3i5o ProboF 0.2406 P0r0o0b1l7 SLoSweer9S5% 009553373 00.503501148113 0882 0059812 FRalio 03957 ProboF 05337 00035 00223 09533 08822 APapgpeen10diLx pUpapoemroossw 002.709474635639 0069285 001591 Source Model Error C Total Source LackofFit Pure Error ToMtaaxlRESrqror 03233 Tom Intercept GENDER(F-M] YRSCHEM Source GENDER YRSCHEM AEllngPianrteiacri/pLaanbts SuInmMma7r0ypopfmFit RSquare. RSquare Adj Root Mean Square Error MeanofResponse. `Observations (or Sum Wats) OF AnSaluymsoisfSofquVaarrieasnce 2 34 0.745787 32371354 36 3.117141 OF SLuamcokfoSfqFuitares 19 9.959941 15 2411413 34 32371354 002252 0.03498 0975755 3.19558 3 Mean Square 0.372894. 0952099 Mean0S.5q2u4a2r1e 1.49409 F Ratio 0.3917 Prob>F 06789 F0.R3a5t0i9o Prob>F 09833 Estimate 3335748 "0.126747 00049036 Noam ro PSarUamEetreorrEstimatteRastio 0250023 0.195906 -1334 065 0.012608 038 DF Effect Test Sum of Squares oa 039853117 013955278 Prob>l| <0001 05220 07042 F Ratio 04186 0.1466 3L8ow4e3r89552% 0524874 0021125 Prob>F 05220 0.7042 APapgpeend11ix L 2U.p8p2e7r694s4% 02713797 00309325 001592 MSoodurecle Ero C Toul SoLaucrkcoefFit TPoutraelEErrrroorr 0M9a9x5R8Sq TInotemrcept YGRESNCDEHRE(MF-M) AGE SGoEuNrcDeER AYGRSECHEM AlElnPgairntoiecri/paLnatbs RSquire SInuPmFmaOrSyAopfpFimt RRoSoqtuaMreeaAndjSquare Error `MOebsaenrvoaftiRoensspo(nosreS:um Weis) OF AnaSluymsiosfoSfqVuaarieasnce 33 8612.59652395467 36 88210203 OF SLuamcokfoSfqFuitares 2 1 85.888903 0.367353 3 86256256 0022151 10.06616677343 57372 3 MeanSquare 026615318332 MoanSquare 268403 036735 0F 2R4at9i2o Prob>F 08613 F7.R3a0t6i4o ProboF 02861 55Es2t3i4ma5t6e 0002139491517189 000946 ParaSmWeEtweorrEstima(tReastio 0136625560634 332 072 0042498 00SI808 047 0.18 Neam OF EffectSuTomsotfSquares [I Lo 13560164 05764525 [Et 00871452 Probslil 0002 Lower95% 891253 0064471678 00402676157014 08562 0.114862 0F5R1a8i8o r0.o4b76s4 0002230353 00.68451672 APpapgeend1i2x L Uppergss 0.18935436955 0.00.9150962692 001593 MSoodurecle. Error CToul LSaocukrcoefFit TPoutraelEErrrroorr M07a3x6R9Sq InTtoemrcept GENDER(F-M] YRSCHEM SGoEuNrcDeE.R YRSCHEM AElnlgPnaretoirciipLaantbs. Rsquare ISnuPmFmOaSryAofpoFimt RRSoqoutaMreeaAndjSquare Error OMbesaenrvoaftRieosnpson(osreS:um Wits) OF AnaSluymsiosfoSfqVuaraieansce. 32 8613.84636480022 3% 88210203 OF SLuamckofofSFqiut aes 1I9s 2362.10309211911 * 86343102 0000231614623 1.s59m35n85 3 Mea0n9S3q3u4a0e 253951 MeanaSqmuaere 154695 R0a3t6i7o6 P0r6o9b5o1F R2a0ti4o P0r.0o6b8r9 SEBsiIm0al3o 0237186 0012347 NpamTo [I ParaSmdeEtreorrEstimatteRsaio 0043018939152 1402754 000918 063 DF Efoct STousmtofSquaes L13O9I5G6S14465 P<r0o0b0ll L6o6w4e7r89653% 0054361326 00.401239022775 0F4Ra9li%o 0P.r4ob6s3F 04003 0.5312 APpapgeen1d3ixL 4U9pp8o8r2o1s2w 00.0857537949476 001594 MSoodurecle ErCToorul SLoaucrkcoefFit TPoutraelEErrrroorr 0M9a9x9R5Sq ITnotrenrcept 'GYERNSDCEHRE(MF-M] AGE SGoEuNrcDeE.R AYGRESCHEM AElngPianroiscripiaLnatbs Rsquare SIunmMm5a5r6ypopfmFit RRoSoqtuaMreeaAndjSquare Error OMbesaenrvoaftRieosnpson(osre:Sum Wets) OF AnSaluymsiosloSfqVuaarieasnce 33 445880170770636 36 50618468 OF LSaucmkoolfSqFiutares 21 404072851795458 n 44807703 0.114795 0L01364s325212 4.6196376 Mean1S9q36u9w2e [EET Mea1n3S9q9u44e 002575 1F .R4a2t6i5o 025% 54F 3R3at6i6o ProboF 0.1071 TE0st0im3el9e 0001405399425 00719096 ParaSmUeEtmeorrEstimatteRasllo 01223040256177 S08434 000033703643 115903 Npam OF EftoctSuTomsotfSquares 1 [a 0302565701194714 [I 50357474 <Pr0o0bs0llll L9o.w44esr85M%4 0016463012 00.518008523682 00628 0004059 0F1R9a6i8o 0P6ro6b0o2F 2372058070 00.01642381 APpapgeen1d4ix L 4Up5p6e0r9d2s4w 000316732762934 0.147879 001595 SMooudrecle CErmToorul SoLaucrkcoef.Fit TPoutraelEErrrroorr 0M3a7x3R2Sq TInotemrcept YGERNSDCEHRE[FM-M) GSoEuNrcDeE.R YRSCHEM AEllngPairntaiocirpLaanbts `SInumMmSarsy pofpmFit RsRqSuquaarree AQ) MRoeoatnMoefaRnesSpqounaser:e Error Observations (or Sum Wts) OF AnaSluymsoisfSofquVaarrieasnco u2 490874753041580 3 50618468 OF SLuacmkooffSFiqtuas i1s9 3118712193589582 3 49843450 000.1054321611 14.62110976768 37 Moan0S3q8u7a5r1e 146598 Mean0S9q5u3a3r6e 21531 F0R2a6t4i3o P0r7o6b9o3F 0FaRsat0i7o P0r9o4b8o6F AETsGtiAm6atLe 000102S7I269159 Noam[I Lo PaSraGmEemteorrEstimatteRsaio 00234130029434 1055326 001893 032 DF EffoctSuTomsotfSquares O04I0S1i9A62T2I3 P<r0o0b0l1 007640733 0F2R7al4l2o 01055 5Lo3w0e4r5S4s8% 000223711366 0P6ro0b3s0F 07473 PAapgpeen1d5ix L U4p1pe3r35s7s4s 0003367647620509 001596 APpapgeend1ix 1 AppendiMx Scatterplots`m(aalnedcrheegmriecsaslioonpse)roaftofrlsu(onro=ch5e2m)icaanld leenvgeilnseoefrfallalbch(nem=ic2a8l) participant with years worked in chemical 001597 w foetssH psas,cos hnseeng 1 . Lt w nwdd pZ . :T s E . AppendiMx Page 2 Ean 2sam] TT wo T w-- enit RiIsnqpureoSdem -S03o6s8n5roymboai vRSCHEM omen RReoomtoo hagenre Err Cronosum Wg fSrroenoesd FH EsSootme or; rPsEta RvaUra alms sooS meem G eeare TH Ho Sn TTeoemsn oCcltuoimasse PGoSaovrTpemSinarTEUmRu30E03s boonenaysl iooommwreiusosn uTbpoeownn 001598 In PFOSdippm = 0.07855P+ol0y.n0o8mi7a1l3 FYitRdSeCgrHoEe=M2- 0.00255 YRSCHEMA2 Require `Summary of Fit 0.152148 RSquare AQ) Root Mean Square Error o117se2 0630532 MObesaenrvoaftiRoensspoonrseS:um Wats) 0.49465528 SMooudrecle. Error C Toul OF AnaSluymsiosfoSfqVuaarieasnco MoanSquae F Ratio 92 139..449850896384 174793 039757 4.395 Prob>F st 2.976802 0017s TInotemrcept YRSCHEM YRSCHEM"2 Estimate PaSrEamreoterr Estim(aRtaetsio Probsli 000087781535421 000313685739 205478 0060133682 0002546 000129 207 00436 L0ow2e5r39751% 000.10005502166 APpapgeen3dix M 0U4p1p0e8r194s1w 001050502017567 001599 wao irsnco, mns 5 w aa 05 . * . : = 2 vr : AppendiMx Page 4 an" TTT- TR rhnie sKP qo N. EAL F-- oJm BAT)bSoncdrewee Swee2 oSsouoe o5rTS J VERSES alm LMMeemsmme furomawee Sa Bo uu a yT2omn SrCHoEimRe OpSSEESREeSonNM Tm olvemn puriese 001600 In PFHSdfpp=m -1.7114P+ol0y.n1o0m0i7a8l YFitRdSoCgrHoEe=M2- 0.00215 YRSCHEMA2 Rsquare `Summary of Fit 033383 RRoSoqtuaMreeaAnd)Square Emor 00.360460673759 `MOebasenrovaftRieosnpso(nosreS:um Wis) "1.06736 52 SoMuordecle ErCrToorul OF AnaSluymsiosfoSfqVuarwieasnce MeanSquwre Ratio 2 9 10082003 20119012 504100 04109 122774 ProboF st 30201015 <0001 TInotemrcept YRSCHEM YRSCHEM"2 Estmalo ParSaUmEemtoerr EstimRaattoiso Probl 0T10U07T79 0010638402296 -1019 293 0<000002l 0002155 0001240 173 00908 L2o0w4e9r19056% 00000436625 APpapgeend5ix M 1U3p7p1o3r7S8s7w 00..10609093657]4 001601 MaielooCAhAaAomaamr!ic5ppaaRsntosCrs E = APapgpee'sndiMx SVoidee! ECmoeur Tneormept VRSCHEM E wo,ST FER te =i an C3 w8ou886 8s m-- Ftit? InP=0OS55uU7mnA1em5a+aorA0fFr0Py1t6P91YpRSCmHEM RRSsqquuaarree AG o00o50r6 RoMoetanitaRneSsqpuoanriee Err Observations (orSum Wis) 0o7s3i9s771s9e 2 os0ir1 0EoSin o0lOmI A"nSiamleolfyVSoaussrmieieanssce 13r3a00t52)2 GPSadrIEammReotrer Esti(maaStl1ee3s 00075 224 MemLSq5u0w8s 020 Fsaoao Probor 002% Pcrooobll L0o3weprldss% 00s 000IISI oUppseroess cos 001602 Term Intercept YRSCHEM YRSCHEM~2 InPOAAppm = 0.30559 Polynomial + 0.10002 Fit dogroe=2 YRSCHEM - 0.00313 YRSCHEM"2 RSquare `Summary of Fit 0.26762 RSquare Adj Root Mean Square Error 0237727 0467638 MeanofResponse: `Observations (or Sum Wats) 0739719 52 Source Model Error CToul OF Analysis of Variance SumofSquares Mean Square F Ratio 2 o 3.915590 10715579 1.95779 8.9526 021869 ProbF 51 14631169 0.0005 Estimate PaSriaEmemtoerr Estim(aRtaetsio Probl 03055886 0122625 0I000IS7 0025126 249 00161 398 00002 0003133 0000911 344 00012 LowerS5% 00591644 000.04094592665 Appendix 4 Page 7 Uppor9s% 05520129 00.010510350028 001603 AppendiMx Page 8 JI i ram anf P ES ia ETT "an TT -- T HIn PieOS=TAI leA0ns2I57oYRSCmaHErMa SRoeoaeteoagnqoeuneSuEmrWeet Srtionne 2 smtp vases pF=oM `Source O30F: SumofLmSSqimuaar]mens aMiele MeanSquare apFfReahoteiedo [Tomi en GSfoioisgmasee cr SuHm EauEe oom Ae iasnetdn Lalonaarmomon Uoupppoweornss 001604 pr Page 9 whcell, "w . EE] oo 50 ot JZ . : gmwrei,mg A "rs esrosrmn pSo R ee Root MeanSquareError es2 1.189837 m p pmeo7 gr EmTVEREaEEE AnalofyVasriiansce eTAmR OwwE=m wwfommal. fdveosmm STBETEtErEcROrT wvOoDnnE owTHnmE oWumRm 001605 ar s Hrow -- e,, mR, oo > So -- Endl wT el, nm TT wo~ TS rls AppendiMx RIioPqueroSSoSmw3Aa0nndaotttespRmSCH=E-M NoetohlaogeEe Chain tum Wee) oYEorvoeon] 2 fHsoocso o0r: tVieASrIhvSas aes eMieim srSeaheee Ena 3 nae eed Tiaodmcll GSfoumwEsne SoSamnSHamtEnerStnh 1e%n e pcoeon ooemmlece Ucppoemrmeenesn 001606 worn aetee ---- AppendiMx Page 11 TT va T rKogeuem, wesa rosis In M55 =-6 2.63d 95-0f .03p 15YRp SCHm EM Bomn AeTSa--s aieh" E sm we T go3r SwCRaEamLvmEso ues crwuelenms oewoneooa iEo SA coerwse SScEEEtEsR omyy smmenm gvomr 001607 J, ww 2 s 2 29 " `AppendiMx Page 12 sre nEpomEa) a te Fn aEopeaEnt Er pr 3 SE Sa w LBEa aBlumm Source: OF `Sum of Squares. kEey Mean Square eiy F Ratio. i. Gumse EA SE py re wren 001608 In PFOSdfppm = -1.6361 Polynomial + 0.13222 Fit degroo=2 YRSCHEM - 0.00282 YRSCHEM2 RSquare `Summary of Fit 0307474 RSquare Adj Root Mean Square Error 0252072 0.845086 M`eOabsnerovfatRieosnpso(norseSum Wats) 066143 2% SMooudrecle Emor CToul OF Analysis of Variance SumofSquaes MeanSquare F Ratio 2 25 7.927078 17854250 396354 071417 55499 ProboF 2 25781328 00101 TInotemrcept YYRRSSCCHHEEMM~2 Estmale ParSaWmEemtoerr EstimattRaetsio Probst L663 0.132248 0336297 005379 487 <0001 247 00206 0002819 0001489 189 00699 2Lo3w2o8r7S253% 000.02025088835 APpapgeend1i3x M -U0p9p4e3r5903s 0020402032646646 001609 AppendiMx Page 14 MalAolPEanrgtiincoieparnitLsab InPFHS pom By YRSCHEM 9 : asd, " EEER PA E: af . . aN . "9 Pos om oH BoB Bw wo MSooudrecle ErCrToorul TInotemrcept YRSCHEM -- lit -- Fad La? InPFHSdfppm = 2.L9i5n2ea2r+F0it.04106 YRSCHEM RSquire SummaofrFyit 0243114 `RRSoqotuaMreeaAndjSquare Error 00927184005083 Mean ofResponse: Observations (orSum Wis) 22324 28 OF ASnumaofloSfqyVuaasriraienscse MeanSquare FRatio 2| 278.79188571961 079958686709 P8r3o5b1>3F 7 32.860307 00077 Estimate PSardaEmmeoterrEstitmRaatleso Probl 0024910552821 00031104221098 925829 <0000007I7 3Lo5w8e9r9857% 00LISSAL -U2p3plo4rs96slt 0.070262 001610 PotmFiodrogsooa=2 In PFHSdfppm = -3.57+13 RsRqquiureeAdj S0.19o973 YmRoSaCFHiEM - 0.00454 YRSCHEMA2 o04s0s0s0o8n8 RMoeoaMnetaRnesSpqounasree Eror Oervaions (or Sum Wits) fExrtioen EF] NSoodurece or> AMeamoyoifvSasarimaesnce oss MemTSwawee lRoaoos EnCreorat n5 5123836304757097 079% paaonst ITnamept SEsSme [ oSusEmsor--1R0asli Po<onnil Lowsorrssss YYRRSSCGHHEEMN2 0010907%4 a00u0ss 330720 00000H8 00000M% AppendiMx Page 15 Uopaperrss Goanoon 001611 `Appendix 4 Page 16 MaAlloPEanrgtiincoieparnitLsab In POAAppTMBy YRSCHEM = z mo : = En 3> g = Ne Fam .. . an Cos onn onows E wo SMooudrecle Error CToul TInotemrcept YRSCHEM -- mit --Paw ae? InP=-O1L.i6n4A o2a9+r FA i0t.018p06YRpSCHmEM RSquare SummaofrFyt 0063628 RSquare Adj Root Mean Square Error 00.903257260123 MOebsaenrvoaftiRoensspo(onrsSeum Wats) 1326223 OF AnSuamololfSyVqasuraiieasnsce MeanSquaro Ratio 21 227153495617951 0L8s74s6109 P1r7o6b6>7F 2 24284865 0.1953 Estimslo PaSrGaEmrootrorEstiRmaatoos Probl 060482087729 0020916365286 515343 <0.010905l3 2L2ow5s2r59057% 0.009867 U1p0pe3r39156% 00459816 001612 Appendix M Page 17 TInotemrcept YYRRSSCCHHEEMM"2 In POAApp = 2.1643 P+o0ly.n1o5m1i6a9lYFiRtSdoCgHroEeM=2Rsquare `Summary of Fit RRoSoqtuaMreeaAndjSquare Error OMbesaenrvofatRieosnpson(osreS:um Wats) MSooudrecle. ECrTroorul OF AnSaluymsiosfoSfqVuawrieasnce 22 168205322620614 2 24284865 21Es6t4i2me8l7o O0I0S0I3G8E2T1s ParSaWmEomtoorr Estim(aRteast 0331972 00S746 640 282 0001496 255 0.00382 YRSCHEM~2 00.21597805552 0".183429622936 2% Mean3S0a2u6a1e3 R4a3t3i0o 072130 Prob 000 P<r0o0b0l1 2Lo8w6e0rS4S8% 0000721 000040069990712 1Up4p6e8r29256% 002.602030774717 001613 noalAroppaEoraripBgyaonvsPnCHEM ad : i" El hPaogpee1n8di1x J Lo TI A waRs Ee InPFOSAAAfzpSmUa3n.e1ra4r1a1oii0nF0a164 YRSCHEM RoRRoqokuvreeeaAnd uae ror oo"oGma2niusezosrs NeOtavamrovattiRoensspoonrseumWet) San4 SVFoiouyee or| A"SnhfosorfrVsyiaur]msa MenTsuhr Resatos 2 son Lenn per Shoat 7 $2 tious Gen TVaRmmSeCnHtEM SEImSo oPSaursatmemetrer EstiIimRLaatSels P<ohal Doles 0oms Oa oar celooowsmrtmssee oTUpspemrmas 001614 In MVSaTAloiopEPnapgrBmiiycepoYarnRitiSsaObHEM "mn : mF : :Podwgew. ----Tt t <n : PS 08woAs bE Appendi4x Page 19 In $70p=p3m.`1S8n0ue4ma+mr0oaF.if0rt0Fyi328YRSCHEM RRsSqquurreeAd 000030615836 RoMeoatnoMfeRaensSpqounasreeError Observaions(or Sum Wats) 1"0223440915 2 SoMuodrecle OF1 A'nSuanolfoSfyqVuasarriieanssce 0050840 Mea0nS5a0u8r4o 0F0r4a8iso ECroral 72 2213248093135 108959 P0r8o2s7e5 TIonemrcept SEIstiMmaSte PaSrUamEeMtrer Esim(aRtaeso 03% 970 P<r0o0b0ll L3ows8r9Ss% aUpspiosroissk YRSCHEM 00st ous 02 ofrs 00s oomsee 001615 In PEiOlASopoAErnas gByciYsnHSeCHEM in . - .t A : go- fof BL).-- Vin woass. AppendiMx Page 20 InPR=OSLu6iS.nm0e7ma9Ar8aF+oirit0dF0yi14f64pYRSpCHmEM RSRRqoquouaMrraeeAndjSquare Er 0"00016243612549 NhisearnvoafioRnessp(oonrsSeum Wee) Sei=s SNoiuocse ori AMenimaoSofirvsiaSzrminseoco MenoSuiise Floassoes CBorw %7 sGaa2s3a0r5e2r8 20 P1o3o:4t ITnRoesmpctEm SEooMimm0d6o OPSasruaEimreostrerEtm1iaRt1ao8is Pcoololl Lmoweroosws eUproress Cols oma Oa 034 00m oosion 001616 TE nfidrspEo--nry --nviw i" . of JRaf TT wd N TTToTo E Aroepeandix InM56 =S43a5a5r5 ryF00y057 YRSCHEM RoRqtuee dy o"mSoesnstss NOReotomrt aMoeiaRonensSqpourarSeaEmrrWores) Fr3 1.297208 Hsoourier or" AnneaoSttveiaannsce Menoswswe FoRomc 6 anim ems pee Eval Srna fied TTJosum chm EGmTs CC[hEm---- Thare Poubnl Goo oss 0m oom Lmooeowmms p"aomrdeems 001617 APpapgeend1ix N Appendix N Scatterplotsfe(maanldercehgeremsisciaolnso)peorfatfolrusor(onch=em1i2c)aalndleevenlgsinocferal/llcabhe(mni=ca9l)participant with years worked in chemical 001618 onsAEE rE os AppendiNx .: "1 RN rNoepe 2 ertbe spornes BreEN rie acoope w=oma or tTErhEEeR Tian oFhs oRremo Ste SroEtEi pt GEE mE ETE iHonEs uowa 001619 sgn Page 3 = 1" - n -- z 17 . 15 ++ Se fsinoEurersaS3o0ea8rspsesovcrmsoasmis SSorbTieSgSeonwg SraommAes osoocze o6rToSnmEutsduL vaaarmna rTwemeos 8 jm aefcnossuee i jroamd CSCoiomnhaoSammmEetETsmSeTeen Psoa rglhooaweesms tuppmresnn 001620 FomaAlaiChPaermiceiapaOnptesrators TM InPOAA pom By YRSCHEM 0"" TF . = Eo Eon as 20 ; wWo u+ PaAgpepe4ndiNx In POAAppm =`0.LS3i2un1em4a8mr-oFa0if.rt0Fyi3t055YRSCHEM RRSSqquuuirreeAdj RootMeanSquare Eror o"o0m0s22is 0715366 OMbesaernvoaftRieonssp(oonrseSum Wt) 007200182 SMooudrecle oF1 ASnumaolioSfyqVuasraimiaansco adsui MeCasuurse Fsreinos ECrTroul 1i0 53s611734680298 sis P0r3o7b3o6r TInoermcept YRSCHEM 03E2s1in4e1t9o PaSrGamEomtrar Esti(mFaatlees OBI 095 P0r3o6v oLowwelrdss% Uvpepresrioos 003058 00328 09 036 0l036n 00ssa 001621 rm, 2 "am + : . 0 + + - AppendiNx Page 5 001622 Fama AC1rpoamriecpaOpnesrators 1 0570oom gy= vse 1 Ne ia . 5 > a) v | 5 wou Appendix Page 6 ESoVnuierercre Cou IYTnoRrSeCtHEM Unoari In570ppm= 2S.1u0m09m-a0o.rl0P3y7t1 YRSCHEM RSquare 0.111759 ROboMRsoeSeqartuvnaMaortefeiaARonednsSjpqoounrrsSeeuEmrWoi) a0T0m2a2i9w3n4 iH oF| A"sSusmoooraSVsaamreamsneca Mem"OSswtween 10 S095 050305 PFhorwoieuor 1 frie [34 2E0m0a00n oSPMaEriarsmoietrserEstiimRGaatlelsso Poroobml 0S 00M I 0:2 LoSowaoeorommssk oeUpmpeoerorsw 001623 ---- Page 7 re m - | J or sn ss rss RsoEoue. RSHEyogrevis eter fo=rma RB oteeSe ve ro B toocse noBrnaamU neaspatnevs"rse sTeoemsaanw eepeenlwcudete Wwwomoh wSCoeommemee eSECenEIrn EEaREnte omwml lDowde Hupeon 001624 Fama aCuhpaarmiaciGapnsoatrs _mM7sssopmeyvasCHEM APpapgee8ndix n; tS o. e Eo : 2 . 20d sq. "50 : & wa .5 EVSmoiueerrc!e Cow YTooRemSreCpHtEM InMSS6opm =S3u.U1mn4o5ma4raoFirf0tF.y0t5942YRSCHEM RRSSRqoquotauMrieeeAndjSquare ror o0o1r9s6e7n3 o54olss MObesaemrvoaftRieonsspo(noreSum Ws) Serie2s o1r| hi DS0EUssisSmeaEllo A"nSailo\f5myoV3ra6osor59i37isas5nsce wsis50 oPasSrGuaEmsmeothrer Estiim7aRte0as 008107 13% Mem0iS3wo9es0e pF1r9ro0un0 aise <Poombli oul Loawwees oussl Urppeeronsw Goes 001625 FoAmalloPEanrgticnpcaanrtisLab In PFOS ppm By YASCHEM ] oT APpapgeend9ix N Ee . : $05 Tt-- wos Bos nox sow TIontrenrcept YRSCHEM MSooudrecle. ErCrToorul In PFOSdfpp=m -L1i.n8o93a9rF+it001024 YRSCHEM RSquire `SummaofrFiyt 0058759 RRSoqoutaMreeaAndSjquareError 050005745777 MOebasenrvoaftRioensspo(onrsSeum Wets) -1.80801 9 OF ASnumaofloSfyqVuasarriieanssce MeanSquare Ratio 71 o1.71818156550844 0021515l56087 P0r4o3b7o0F 8 19002048 05297 Estimate PaSrWaEmmeotrer Esti(mRataeos Probf 0L08190293I937 00210257749 809606 0<50209071 2L3ow9e7r09559% 0026388 -U1p3p9e0r796s6w 00463678 001626 JruCsI s A ---- AppendiNx Page 10 TT wa T drones RaiInqeP umeegFH r=eF-S 3r.9e8l6d 8+t0f .030p 15YRp SCHm SeoEMromaoes eeemeSoe ge i) Bsi=e a or7To oCEnSRmEsaS She sMeamSmwrmyes orroawmee Ve frToui mit SCchoomemmmee CS CsomwmCmeH oeuTE sne E Calwln saloemnmna rguomeseses 001627 FoAmlalPoaErnigcipnaonatrsLab W In POAApomBy YRSCHEM 19 w Fw) amd 19 HER AE BE EBEC IF wow PAapgpe1en1diNx SMooudrecle ErCrooru TIonemrcept YRSCHEM In POAApPm = 2Li.ne5ar+6F0i0t202889 YRSCHEM Rsquire SummaofrFyit 0001765 RoRoqtuMreeaAndSjquare Error 008.4154205874 OMbesearnvaotfiRoensspo(onrseS.um Ws) 25%) OF1 AsnumaolioSfyqVuasraiiwasnsco 00089035 Mea0n0S0q8u9a0r4e 0F0R1a2i4o 87 550043576775961 0719539 P0r3o1b4o5r 2E5s2ti7n8at5e PaaSmWEemtoorr Esti(mRataels 03STOTL US P0r0o0b0l2 00028915 0025994 OL 09145 Lo3w4sr0S7s3% 0058575 1Up7p1e8r4d3s9i 0064384 001628 FomAalloPaErnicginpoaanrtsiab TE In PFOSAA ppm By YRSCHEM 5 5 f go. al--l Zan Tan an VS n w8s as8w PAapgpeen12dix SMooudrecle CEooarl Tnoirmcept YRSCHEM In PROS=SLAu6i.nme1mAa4r3ao4i-frdt0Fyi.t0.I2633pYRpSCHmEM RSRqSuqaurreeAdj Root Mean Square ror 00..10023428646 0957088 ObMseearnvoaftRieosnspoonrseSum We) "6364315 OF1 ASnuamoliofSyVuasarimiasnsca O77 Me0m7m3S8a4u0w7e Roadeb)o 87 7614510251229285 0916018 P0r3o9v9o1r CEsIirMate SParUameEtor 04S Esti(mFaatelse 1525 P<r0o0b0ll LTowoercdso% 0026333 00929 0% 0399 0095686 sUpoperroesw 00430209 001629 FemAalllePaErntigciinpoanatrsLab In MS70 ppmBy YRSCHEM m . Som an TT Et Es wos nos nok st APpapgeen1d3ix N TInetrermcept YRSCHEM Source EMmodoerl C Toul In 57=03.52p L3in3e+ap r0.Fi0t1m215 YRSCHEM RSquare SummaofrFyit 0030399 RoRSoqtuaMreeanAdSjquare Error 00..81406821028 MeanofResponse: Observations (or Sum Wis) 342136 9 OF AnSuamoloffSyVqausraitiaenssce MoeanSquare 1 7 01571845 50135469 0.157185 0716221 8 51707315 F0R2a1t9i5o P0r6o5b3o7F Estimate PSaWrEammeotrer EstitmRaatteso Probs 3523219 00121493 0356247 0025934 989 047 <0001 06537 4L.o3w6e5r69756% 0049176 2U.p6p8e0r8983s 00734743 001630 FemAallloPaErntgiciinpeaanrtisLab In PFOSA ppm By YRSCHEM an Zin =an an SS . . moo w 8w s g sow APapgpeend14i.xN TIontrerncept YRSCHEM SMooudrecle. ECrTroul In PFOSAdfppm = -Li5n.e5a2r85Fi+t 0.007 YRSCHEM RSquare `Summary of Fit 0.002879 RRoSoqtuaMreeaAndjSquare Error 10..61035995372 OMbesaernvoaftRioensspo(onrsSeum Wes) 5.46983 9 OF AnaSluymsiosfoSfqVuaruieasnce MeanSquare 71 108005523112137 02507291022 8 18105239 FR0a0t20i2o ProboF 08910 Estimate SPadrEammoetrer EstitmRaatleos Probsil 0S00S69S96I2 0060746201122 801184 <0o80901l0 7L1ow2e7r0S8S4% 010978 U3pp9e7r99058%5 0.123366 001631 FamAallloPaErnigciinpoaanrtisLab * In M556 ppm By YRSCHEM ge " 2 . 9 TT :0 CS woo wo8m s s so PAapgpeen1d5ixN MSooudrecle ECrTroourl ITnotemrcept YRSCHEM In MS56dfppm = -5L.i0n7e0a1r+Fi0t.02647 YRSCHEM RSRqSquuiarree Adj `Summary of Fit 00..10109643716 MRoeoatnMoefaRnesSpqounasree Error 04..88846530852 `Observations (or Sum Wes) 9 OF1 AnSaluymsoisfSofquVaarrieasnce 07482412 Mea0n7S4q6u2a4r1e 0F 9R4at9i8o 7 3 5624495997516553 0785674 P0r3ob6s2F SEsOtimIate SPaGrEammeotrer EstimtaRtaeiso. 0312-1359 <P0ro0b0sll 0026472 027162 097 03622 5L9ow5s2r491S5% 003757 4Up1p8e7r9358% 0.090701 001632 APpapgeend1ix 0 Appendix O wShcaottweorrplkoetds w(aenrderoenglryesisniotnhse)foiflfmlpuloarnotc(hnem=ic3a6)l wlietvehlsyeoafrsrawnodrokmedsaimnplfei:lm 001633 (MaintOornRlayanncFodioWmmorESkmaeprmlsopyNleueemsbered) 0PFOS ppm 8y YsFim 19 ES 2 it a 5. Zand = a5 . an S93 ot wet. ee "& a Sian so. * ws vie a 8 a PAapgpeen2 diOx IRPF=S2uLO3mi0nm2Se4aaor+fr0lPy0t0p313pYrsFmilm RRsSqquuiarreeAdj RootMean Square Er 0"000022964388 038965 OMbseearnvoatfiRoenssp(oorrseSum Wets) 2259346 SMooudrecle OF AraSlumooffVSaraiasnce | 0034516 Memon0S%qsulaeo F0.r100a5 ECmoral 34 U117E085S95 033s P0r7o5b3s1F TIomemrcept 2Es3i0m2a3l7o SPaUrEammerterEst(iRmaitoes Ol 1379 P<ro0bl L2oewiesrsss% eUppeerosst YrFilm 0003336 00083 032 07531 Ooi ooamisr 001634 Appendix Page 3 ITnotemrcept YrsFilm YrsFilm'2 InPFOSdfppm = 2.5P1o1l7yn+om0i.a0l62Fi0t9dYergsrFeiel=m2 ~ 0.0021 YrsFilm2 RSquare Summary of Fit 0083482 RRoSoqtuaMreeaAndjSquare Error 0027935 0570251 OMbesaenrvoaftiRoensspo(nosreS: um Wats) 22594366 SoMoudrecle ErCrToorul OF AnSaluymsoisfSofquVaarrieasnce MeanSquare Ratio 2 3 100977371415832 00.342858178266 1.5029 ProboF 35 11708595 02373 2E5s1ti7m0at2e 00000622009879 SPWaWrEarmoorlar EsRtiamtaitoes Probsl 00023053970313 1213733 <0000903I4 0001231 170 00980 2L9ow2e6r193s2% 0000014061072 2U0pp9e7r297s2s 00..305010098445 001635 FoFoaynsdFoipmmosmEmayolraeesn . - gar ard m . Fw {7 TN sependi0x Page 4 ZL] , * TTR wr38 3 a i -- tat RSquFreSp=S4nu7a5m1saePn00y0958 Yimcons NRoReowtgboefaRaneSpqosre Ero oiSsoerzntniite Onsen orSamWet) s NEsaraurece ori An"aEsaovtmansece we"nsOammee srs OTR pForesares Coat 0 oe 5a TnYoocmren GaEoninsne SGPeaanwmtsEsilimhayoes PCoobill ool 06 oss LG`oSohweassn Uohogpueuerdoinosss 001636 Appendix Page 5 ITmoemrcept YYrrssFFiillmm'2 InPFHSdfppm = 5.30P1o9ly+no0m.i1a6l5F2i3t dYergsrFeiel=m2- 0.00548 YrsFilms2 RSquare: Summary of Fit 025279 RRoSoqtuaMreeaAndjSquare Error 007.7290469069 OMbesaernvoaftiRoenssp(oonrsSeum Weis) 45868335 MSooudrecle Eror C Toul OF AnalSyusmiosfoSfqVuaarrieasnce MeanSquaw Ratio 22 19.6454738627305 036208796112 P5r4o1b3o2F 3 26021905 00094 53Es0t1i8ma6t4e 001060552438313 SPWaErmamoerter Est{iAmsatoes Prob>| 00209520929896 183.2100 <000000215 0001706 321 00030 5L8ow0e8r69754% 0062798 -0008957 4U.p7p0o5r0o5s3s 02676682 -0.002006 001637 (MaiionOarRnyacFnoidWmoomrESkmaepmrlspolgReousmbsored) In POA pomy Vstim i a a wt Gm a bp Els > 3 nT : FN Appendi0x Page 6 4st 55 PS w 8a 8 vn Tmoemrcpt Yiskim SVoiuecro EmCerorat f-- hrit? 1EP=SO3u5nm3Ae3ma6a+oFrAirf0Fy0t1p719pYrsTMFim RsRqauurme Adj 000o0l9i2s3s ROoMheoeatrnvMoaefiaoRnneSssqpuo(anorsreSeEormrWoir s) 0S.a83s8o538l4 or| A"BnneoatfSVwaiarimasence 0sbore MemoSmuomrew Fsoreu: xn B2416965656 own P02e0t3 AESsmHe 0SPua2trae8merterEstRliamaaets.es Pcuoblmi Laoowwemres 0071s 0019 Lis 024 oo oUppsarossk obese 001638 InPOAAppM = 3.95P8o5ly+no0m.i1a3l11F5itYdrosgFrialem=2- 0.00401 YrsFilmn2 Rsquare Summary of Fit 0.179823 RRoSoqtuaMreeaAndjSquare Error 00.718278550602 Mean of Response Observations (or Sum Was) 329191 3s MSoodurecle ErCrToorul OF AnaSluysmiosiofSVqauriaasnce MeanSquare Ratio 22 149385415046915 20612705157 P3r5o0b8s0F 3 24.196556 0.0419 TInotemrcept YrYrssFFiillm.m2 PaErsatmiemtaetre EstimSatUeEsror 03.915381540647 00025906800068 000013 000124 -R1a3t3i7o Pr<0o0b0l1 223538 0000216446 PAapgpeend7ix 001639 (MaitaOFrlaaynnFcdoioWmmoErmSkpaelmrospylNeeuemsbered) Ww In PFOSAA ppm By Yrsiim dlb a 49 . L.. =. F2 anez n : 25 an Nate ee --. VS 6 vin8 a8 a PAapgpee8ndi0x TInoemcept YrsFilm MoSoduerlce ErCoorl InPFOSAAAfpSp=muLm6i.nm1e1a4ao3irrf.t+Fyt000041 YrsFilm RSRqsuqaurree Ad 00.00300002371 OMRbeosoaetnrvMoafetiaRonenssSp(qoounrasrSeeuEmrrWorats) 0".67.319058375s46 oF| ASnuamolo0if0ySV0a0usr5eii5as3nsco Mom00S0qu0a5r5e3 F00r0i1o0 M5 1188005500051614 0546970 P0r9o7v4o8F 6E4s2ta6t0e 0PSa2Ur1aEm8me8rtor Es2i(m7Ra9atl3oes P<r0o0b0ll L6ow5e9rd9s9% 00004063 0012779 003 098 0025593 USppeewr0ssrs 003640 001640 (MainaOnaRynacnFadiWomamrESkmaapmrlpsolyNaeucmsbered) Ir InM68yV7sFi0im 1 m " gun To " an a v5 wn win8s 8s NSoaudreco ECmorl M570 = 4.8U0n4o6ar F0.u00844 YF RRSSqquuauree Ag `SummaofrPyi o"0000s2t360r6 RoOMeosatenrMovefaatRneiSsoqp(unooasnrrsSeeuEmrrWoeris) F1.0e895oi33 oF| A"Snumoao0ff2SV5aia0rr1ie5ass8nce MemonxSa0uie 32 "40036610288256 LIE08 InTcorrncept YeFim 4PaSCr0aaMm6metlae2rEsim0aSt3o1os03r4 RSa4t5o Do0sul 00 04s F02r11a0 POroobie <P0roooblo 06a PApapgeendi0x 001641 wJn, 50 Te 2 . 2m J . : tBELoot,aenf,LpEa-E --iiozs InM556dfp=pm -6.0381 +0.00926YrsFilm rEEeE r _st-- 001642