Document kY8yJnYrEMzwrQoj3kGj04Zb

SEP-26-1995 10=39 P.01/04 02253 UJ University of Illinois at Chicago School of Public Health Epidemiology-Biostatistics 2121 W. Taylor St-Room 503 (M/C 922) Chicago, IL 60612 Tel: (312) 996-8860 Fax: 996-0064 DATE; TO: ^ ,rX b / ^3 No. of Pages: (including cover sheet) 'JIM fontJ/3____________ fax. FROM: -I i ________ 17 iClc-i___ f /tsl-. I? I. ^ ) (pP/ Vy// TEL: MESSAGE: -4 fYlP^T fnclaJtA IS /f I. A a Ara'ff' Q-& GOr* ffcA /fo enclosed ASTHMA BETS BCL CBTRUS CDCMB cdcnh CDC RISK CPPV SENDER: Please check fV) the area to be charged: _ DASA AUSTIN _ DASA _ DIABETES _EBA _ EBLAB __ EBBS __ EBES EBF . ERC.ERIE _ HRM . IDPH FLOOD " IDPH MOBILE . I.S. ORUPE . JBT NBLIC Have a nice day !!! __NIDA R01 __NODP _ OVARIAN __PERSONAL __ SCPA __ STEROIDS _ WIHS __ OTHERS: DSW 476038.0996 STLCOPCB4043156 SEP-26-1995 10:39 P.02/04 THYROID FUNCTION IN WORKERS EXPOSED TO CHLORINATED PHENOLS AND PHENOXY ACID ESTERS. VW Fersky1, DO Hryhorczuk1, W Wallace2, S Fumer1, JR Webster*, DM Oleske3, B Hazlehorst. `University of Illinois School of Public Health, Northwestern University, 'Rush Presbyterian St. Luke's, Chicago, Illinois In 1986 we compared the health status of 473 workers previously engaged in the manufacture of chlorophenols and chlorphenoxy acid esters with that of 303 unexposed persons who had worked at the same plant. A total 260 persons had worked with pentachlorophenol (PCP), 55 with lower chlorinated phenols (LCP), and 31 with esters of 2,4,5-T (EST). A total of 82 exposed workers had either a history of chloracne or physical evidence of chloracne at the time of medical examination. Thyroxine (T4) levels in 1986 were significantly higher among all exposed persons and exposed persons with chloracne on univariate analysis (8.00 and 8.23 vs 7.71 ug/dl). The differences remained significant, however, only for those with chloracne after control for confounders (age, gender, race, diabetes, pregnancy, cirrhosis, lymphoma, throat cancer, and selected medications). Mean free thyroxine index (FTI) was also significantly higher among all exposed persons with chloracne after control for confounders. Persons who worked with PCP and EST tended to have higher levels of T4, but differences were only of borderline significance. Persons who workers with LCP had only slightly higher levels of T4 than unexposed persons while those who worked with LCP who also had chloracne had significantly higher levels of T4 after control for confounders. There were no significant differences in TSH among any of the exposure groups- DSW 476038.0997 STLCOPCB4043157 SEP-26-1995 10=40 P.03/04 Announcement/Call for Papers THIRTEENTH INTERNATIONAL NEUROTOXJCOLOGY CONFERENCE Developmental Neurotoxicity of Endocrine Disrupters Dioxins, PCBs, Pesticides, Metals, Psychoactive 8l Therapeutic Drugs October 29 - November 1,1995 The Arlington Hotel & Spa HOT SPRINGS, ARKANSAS USA For information please contact: Dr. Joan M. Cranmer, Conference Chair Department of Pediatrics - #512 University of Arkansas for Medical Sciences 4301 West Markham Little Rock, Arkansas 72205 USA (501)320-2986 / FAX: (501) 320-4978 Affix Postage Here Sponsors: Agency for Toxic Substances and Disease Registry U. S. Environmental Protection Agency University of Arkansas for Medical Sciences National Center for Toxicological Research / FDA Arkansas Children's Hospital Dr,.Victoria Persky University of Illinois School of Pub. Mea 2121 Taylor Street Room 508 Chicago, IL ABSTRACT DEADLINE: \ JOCTOBER 1, 1995 DSW 476038.0998 STLCOPCB4043158 SEP-26-1995 10:40 P.04/04 DEVELOPMENTAL NEUROTOXICITY OF ENDOCRINE DISRUPTERS * HOT SPRINGS, ARKANSAS USA PRELIMINARY PROGRAM Sunday Afternoon - Oct. 29, 1995 (2:00 - 5:30 pm) |A. OPENING, WELCOME AND OVERVIEW Opening and Overview of the Conference DR. JOAN CRANMER university ofArkansas for Medical Sciences Welcome Representatives of the Sponsor and Host Institutions IB. EMERGING ISSUES: PUBLIC HEALTH & SCIENCE Neurobehavioral Effects Arising from Environmentally Relevant Chemical Exposures DR- THEO COLBORN World Wildlife Fund Toxicological Issues Provoked by Environmental Estrogens DR. STEVEN SAFE Texas A&M University Early Development: The Sensitive Stage for Environmental Endocrine Disrupters DR. LINDA BIRNBAUM US epa WeCcomng `Reception: 5:30 - 8:00pm Monday Morning- Oct. 30,1995 (8:30-11:30am) II. TUTORIALS & REVIEW Chairs: Drs. Bernard Weiss and Babasaheb Sonawane The Course of Neuroendocrine Development DR- THOMAS BADGER Univ of Arkansas tor Medical Sciences Behavioral Markers of Neuroendocrine Development DR, ELAINE HULL University of Buffalo Actions of Environmental Agents Linked to Neuroendocrine Function DR. THOMAS GASIEWICZ university of Rochester Environmental Endocrine Disrupters, Sexual Development and Risk Assessment DR. BERNARD WEISS University of Rochester Monday Afternoon - Oct. 30,1995 (1:00 - 4:45 pm) III. PCBs & DIOXINS: ANIMAL STUDIES Chairs: Dr. Deborah Rice and Dr. Hugh Tilson PCBs and Related Compounds: An Overview of Animal Research DR. HUGH TIL50N us spa Role of the Thyroid in PCB-Induced Cognitive Dysfunction DR. SUSAN PORTERFIELD Medical College of Georgia Behavioral Effects of Postnatal Exposure to an Environmentally-Relevant PCB Congener Mixture in Monkeys DR. DEBORAH RICE Health Canada Neurobehavioral Effects of Developmental Exposure to Orthosubstituted Versus Coplanar PCB Congeners DR. SUSAN 5CHANTZ University of Illinois Structure Activity Relationships of Potentially Neurotoxic PCB Congeners in the Rat DR. PRASADA KODAVANTI us epa Sunset Dinner Cruise andDance Tuesday Morning - Ocl 31,1995 (9:00 am -12:30 pm) IV. PCBs & DIOXINS; HUMAN STUDIES Chairs: Dr. George Lambert and Dr. Walter Rogan Human PCB Toxicity Studies; An Overview DR. WALTER ROGAN niehs Evidence for PCBs as Neurodeveiopmental Toxicants in Children DR- JOSEPH JACOBSON Wayne state University Results of the Dutch Study on PCB-Induced Neurotoxicity in Children DR. CORINE KOOPMAN-ESSEBOOM Sophid Children'* Hospital, The Netherlands Neuroendocrine Developmental Effects in Children Exposed In Utero to PCBs: Studies in Taiwan DR. LEON GUO National Chenh Rung University, Taiwan Evidence for the Role of the Ah Receptor/P450 in PCB-Induced Toxicity, Neurotoxicity and Endocrine Disruption in Humans DR, GEORGE LAMBERT Rutgers University Tuesday Afternoon - Oct. 31, 1995 (2:30 - 5.00 pmj V. POSTER PRESENTATIONS - All Papers Welcome! (Student Award winners wiR be selected during this Session) Wednesday Morning - Nov. 1,1995 (8:30 -11:0Q arn) VI. PESTICIDES/METALS/DRUGS Chairs: Dr. William Slikker Jr. and Dr. RobertJoy Pesticides as Neuroendocrine Disrupters DR. PENELOPE FENNER-CRISP us EPA Organochlorine and Pyrethroid Insecticides as Neurobehavioral and Neurochemicai Disrupters DR. ROBERT JOY uc Paris Behavioral Effects of Environmental Exposure to Lead Using an Avian Model: Field and Laboratory Studies DR. JOANNA BURGER Rutgers University Methods for Assessing Adverse Neurodeveiopmental Effects in Children Exposed to Cocaine, Ethanol or PCBs DR. SANDRA JACOBSON Wayne State University Wednesday Afternoon - Nov. 1, 1995 (11:15 -1:00 pm) VII. RISK ASSESSMENT & RESEARCH NEEDS Chair: Dr. Hugh Tilson Report of EPA Endocrine Disrupter Symposium: Neurotoxicology Research Needs DR, HUGH TILSON us epa Panel Discussion: Risk Assessment & Research Needs DRS. AMLER, BIRNBAUM, FENNER-CRISP, LAMBERT, SEEGAL AND SHANTZ 1:00 pm Adjourn Conference Optional fours of NOTH, UAMS or ACH (TOO- 5:00 pm) TOTAL P.04 DSW 476038.0999 STLCOPCB4043159