Document kXQqNBo3nRMGazpNL8oKvdbO

Guidance Note EH 15/80 from the Health and Safety Executive Environmentaf hygiene 15/80 Threshold Limit Values 1980 Introduction 2 Threshold Limit Values for chemical substances in workroom air adopted by ACGSH for 1980 Preface: chemical contaminants 6 _________ Adopted values 9 _________ ______________________ Notice of intended changes 15_____________ _______ _________________ _____________________ Appendices____________ __________________________________________ A Carcinogens 17 B Substances of variable composition 19 C Mixtures 19 Q (See Introduction)___________ ________________________________ _ E Some nuisance particulates 21 F Some simple asphyxiants 21 G__Conversion of mppcf ?o mass concentration 21___________________ --^--Hi-- References 22 ....... ------------ Publications 23 The list of threshold limit values (TIVs) in this Guidance Note was adopted by the American Conference of Governmental Industrial Hygienists IACGIH) at its annual meeting in 1980, and is reproduced with'its permission. It is*a condition of this permission that the list is published in its entirety. Some^of the substances listed may not be available or used in Great Britain, There are also a few substances for which the values used in Great Britain differ from those quoted in the list. Details of these are given in the Introduction, and they are indicated in the main list and the Appendices. WV-15714 This guidance net8 eH 1$ 8C revises and ..m, n, 5r*. vious documents in this series. It reprodiiLo i,S{5f threshold limit values {TlVs! published annuls, Dy th4 Amsncjr Conference of Governmental indi^i,^, H'i^ienistSiACGtH') and si$0 lists these 3Ui)Sl-M<> iQt which the ACGiH proposes changes to the aau.,,^ vetoes or for which is proposes to introduce av.n,,,, f0f the first time. in addition the guidance note gives information those substances for which different values have been agreed ir> Great Britain wr -n .v plain* the underlying philosophy. The following cc>nrs ,v-t of yjrricular importance' la! TLVssrA not sharp dividing lines between 'safe' and 'dangerous' concentrations (but s^sspeciat comments for suosianceswith a 'ceiling' (Cr limit). (b! The best working practice is to reduce concentrations of an airborne contaminants as far below the Tiv asis reasonably practicable. In the case of substances not quoted In the list or where there erg no known toxic affects. expo$ure shoutd be kept a$ Icw asis reasonably practicable*, All these vaftreegive guidanceon levels to which exposure to toxic substances should be controlled in order to protect ihs heaIth of persons amployed.. These levels form pan of the criteria which are used by the Health and Safety Executive 5n assessing compliance (c) The absence of a particular substance from the list does not necessarily indicate that h is 'safe'. {dl The application of any TlV in relation to particular circumstances should be interpreted by a trained occu pational hygienist. v#ith the Health and Safety at Work etc. A 1974 and other relevant statutory provisions. Threshold Limit Values ftlVs) The avaluation af limits to which exposure to toxic suostences should be controlled in order to protect the hecitn of persons employed requires consideration of a number of factors. Further information for indiv idual substances is contained in Documentation ofThreshold Ur.it Values for Substances in Workroom Air published by th3 ACGIH. This gives relevant sciantifre info rmation, references to the literature sources which were used to errive at each value and also states the type of response auuinst which the value is intended to protect the worker. tv'uiries concerning the availabslity of this publicstlon should be directed to the Publications Qffic*. American Conference of Governmental Industrial Hyg-enists, PO Box 1337, Cincinnati. Ohio 45201, USA. Past experience ho# yhcwrt that the documentation foran entry in the 'Notice of Intended Changes' list may not be always immediately available. long hours ofwork Threshold limit values are generally based on work schedules involving five shifts of eight hours duration in a working week of40 hours. Where working times greatly exceed this, the simplest approach in assessing relevant permissible concentrations in the atmosohera would be to make a pro rata reduction in the published TIV, but this method should be used with caution, due account being taken ofthe properties of the material being handled, the biological balf-Si/e within the body and the effect of reduced recovery time. Notice of Intended changes Attention is particularly drawn to the list of Intended changes on page 15. The proposals usually remain on the list for two years to allow time for comment and for the presentation of evidence to the ACGiH. If, after two years, no contradictoryevidence has been out tonverb, the values are normally adopted by the ACGIH at its annual meeting and transferred to the Adopted List. The major changes introduced in 1376 {Short Term Exposure limit {STfiU values andgradlng ofcarci nogens! are continued in the 1930 list. The ST$L values are derived from a number of sources and users of the 11st are advised to interpret them cautiously, beanng in mind Iheir Urnitations as set 0ut in the Prsface so We ACGIH list. in this issue the ACGIH has omitted Appendix D, which had given permissible excursions forTime Weighted Average {TWA! limits, and all references to it. The remaining Appendices however have not been redesig nated to take account of this. For a betterunderstanding ofthe use made ofTlVstn the provision of healthy working conditions, careful atten* tion should be given to the Preface to theACGiH list. Control limits The term TLV should not be confuasd with that of 'control limit', which is being adopted in Great Britain to indicate those levels of airborne contaminants, averaged over a specified time period, above which personal exposure Is constdered to be onacceptable and if eantinued might merit enforcement action. An essential Feature of the derivation of control (imits >s that they are agreed by the Health and Safety Commission after consideration of all the relevant data by the Advisory Committee on Toxic Substances (ACTS), which consists ofrepresentatives of the Confederation of British Indus try, the Trades Union Congress, the local authority associations and independent experts. See Guicer.ee Nota EH18. Toxic substances, a o'ecauoorwy 2 SC-UK-MS-000107 Safa systems of work Thg wisdom of ensuring that exposure to any substance iskept as low as Is reasonably practicable, whetheror not n is known Ior. present informat/on) ir be hazardous. has bean shown by the discovery of previously unsus pected and senous long-term health hazards associated with substances which have been used for many years and hitherto had been assumed to be comparatively safe. All substances should be handled w*th care, whatever their nature, iest future experience shows them to present a hazard which could have been prevented or limited by the application of sensible control measures. The policy adopted by the Health and Safety Com mis sion* is therefore (a) that exposure should be kept as low as is reasonably practicable by the application of occupational hygiene principles and techniques appropriate to the route of entry into the body (inhalation, ingestion or absorption through the skin}. Ibl that in any case exposure should be keptwithin the published standards, e.g. TlVs. control limits agreed by the Health and Safety Commission etc, by the application of engineering controls or other suitable control techni ques. (c) and that, where necessary, suitable respiratory and other protective equipment should be provided and used. The provision and use of personal protective equipment should normally be regarded as providing a beck-up for other techniques which aim Co control the risk at source, rather than aa a Rcat line of defence. In certain circumstances however, personal protection may be the only reasonably practicable measure, in which case caremust be taken to avoid exposure of others who may be in tha vicinity. Sampling and analysis Where the atmosphere ofa workpface is ftfcefy to be contsminated.sampling ofthe atmosphere and subse quent analysis should be carried out on a periodic basis with a frequency determined by conditions, in Greet Britain there are specific legal requirements for the regular measurement of airborne eontomination in the Chromium Plating Regulations 1331 (SR and 01931, No. 455 as amended by St 1973, No. 91, in the Coal Mines ffiespirabie Dust) flegulations 1975 (St 1975, No. 1433 as amended by Si 1978, No. 8075 and in the Control of Uad atWork Regulations 1980 (S11980. No. 1248}. There are also detailed recommendations on such measurement in Vinyl Chloride: Code ofPractice for Health Precautions end in the Code ofPractice for ControlofDust from Portable Power Operated Grinding Machines. Aov'zs cn. :n? sampling of asoasios ,s given in Guidance Note EH to?. Details of methods of tamc^g ard analysis of certain substances is given ,n ;rs sen*? of bock'ets, Methods for the Getset/on of To>-c Suostances (n Air, listed 0" page 23, These are currano'y 6emg replaced by a new series enMied Methods forthe determination ofhazardous substances (sea p 23). Advice may also be obtained from or through inspectors of tn& Health and Safety Zxesviive. Where appropriate, the performance of control equip ment, such as local exhaust ventilation appliances, should be checked on a regular basis us>no suitable instruments. Tyneif tight beams are parpcularlyuseful in tha qualitative assessment of the operation of local exhaust equipment used in containing sources of air borne dust. Detailed advice on the legal requirements concerning the safety of me atmosphere of workplaces, which are contained in the Health and Safety st Work ate. Act 1974 (HSWAct}, the Factories Act 1961 and various sets of regulations made thereunder, may be obtained from inspectors of the Health and Safety Executive. Substances forwhich additional or alternative standards apply in Great Britain* Acrylonitrile Following advice from the Advisory Committee on Toxic Substances (ACTS) based on consideration of the toxico logical and epidemiological evidence, the Health and Safety Commission (HSC) issued a policy statement in 1979 to the effect that scrylonitrileshould be regarded as a potential human carcinogen. The policy of the HSC is that exposure should be reduced tq a level as low as Is reasonably practicable, with the objective of working within a control limit f2 ppm,8-hour time-weighted average (TWA), by 1981, in otder to aIlow time to carry out any necessary alterations to plant and operating procedures an imerim !imit of4 ppm, 8-hour TVVA, was applied in certain circumstances, Anyplants which were capable ofworking within the control limit of 2 ppm, 8-hour TWA, were expected to do so. Asbestos Hygiene standards applying in Great Britain are pub lished in Guidance Note EHlOT.and are abstracted below. (a) Exposure to all farms of asbestos dust should be reduced to die minimum that is reasonably practicable: and (b5 in any case, occupational exposure to asbestos dust should never exceed: for crocidoiite 0*2 fibres/mi when mea sured over any ?0>rmnute period: 'Guidance Note SH18, Toxic substances' a precautionary guticy. tGuidsnca .Vore >0. Jstestos.' hyciaoa standards and measurements of airborne dust concentrations. HMSO. *inalced by a 'double dagger <*l. n the tut of Adopted Vaiges SC-UK-MS-000108 fcjrotfic' tycss c1 .*i324s:o5 2 hbretmVvihen measure ments are averaged over a 4'ho^r period; short-term expoaureshouid notexeeed 12 fibres/ml when measured over any 10-minute period. Note: Fibres means particies of length greater than 5 ^m, a diameter of less than 3 m and having a length to breadth ratio of at least 3:1, observed by transmit* ted light under phase contrast conditions at a magnification of approximately 00x. Benzene Senzene is listed as a suspect carcinogen at Appendix A, paragraph A2. Epidemiological data however, show that the chronic effects of exposure to benzene are those on the blood-forming tissues leading to disorders ofthe blood and bone marrow. The condition, known as leukaemia, is a form ofcancer. Since the informations far avaiiaW e Indicates that such chronic effects usually result from exposure to concentrations significantty>n excess of 10 ppm, 8-hour TWA (the listed TtV) it was concluded by the ACTS in the light of current knowledge that a change in the control limit could not be recom mended at present. The situation is being kept under review, but benzene should De regarded as a proven human carcinogen, and exposure kept as low es reason ably practicable end in any casewithin 10 ppm, 8-Hour Chromium metalandchromium compounds Mdny entries for chromium and chromium compounds epceer under Adopted Values, Notice of intended Changes and in the Appendices, and these may cause some confusion, In general, whenever exposure to airborne chromium in the hexavalent state occurs e.g. welding of stainless steels, the preparation and use of chromate solutions and handling of chromate pigments, a TLV yf i 1 mg/m3 (determined as CrOjf or 0.05 mg/m3 fd&terr '-d asCr) should be applied in respect of the hexavalent chromium content ofthe aIrborne material. The list of values as applied in Great Britain is as follows: tsm-Bur/i chromate -- Skm Chromium metal Chromium divalent andtrivaism compounds Ch. omium havalsnt compounds 0.05 mg'm* (determined as CH, ceiling 0.6 mg/m3 (determined as Crt, B-hour TWA 0.5 mg/m3 (determined esCr), B*hour TWA 0,05 mg/m* (determined asCr>, 8-hour TWA Guidance Note Ccrron Oust sampling. HMSO. Conon dust The hygiene standard adopted in Great Britain, 10 be applied to she preparatory stages of spinning raw cotton up to and including winding and beaming, is 0.5 mg/m3 of total cotton dust, less fly, 8-hour TWA. Guidance Note H 25* deals with methods of measurement for cotton dust. Dust in coalmines Petmined levels of respirabie 0ust in cc A minas are 1aid down in the Coal Mines (Respirable Dusil Regulations 1975 and the Amendment Regulations of 1979. These limits are th ones which apply in Great Britain, Lead An Approved Code of Practice supporting the Control of Lead at Work Regulations i960, hos been published. The 8-Hour TWA standards set out in the Code are: Ttrsethyl lead: 0.10 mg/m3 of air \es Pb) Lead (except Tetraethyl lead}: 0,15 mg/m3 of atr (as Pb} 4,4'`Methyiene-bfS~{2'Chloroeniline) Following th publication in 1978 of the TLV of 0.02 ppm (220 g/m3}, 8-hour TWA. further evidence emerged suggesting the need for e lower limit. After consideration ofthe epidemiological end toxicological data tna H5S in 1978 recommended a figure of 60 ug/m1, B-hour TWA, and this was first published in theIntroduction to Guidanee Note EH 15/77. The matter was subsequantiy discussed by the ACTS which decided to endorse the recommendation that a figure of 50 ,ug/m3 should be adopted, adding that it must be bom in mind that skin absorption could a?so be an important route of entry into the body. Mice andtele Thestandard of roglm5,3-hour TWA, of tots* airborne dust applies to talc and mica, with a qualifying limit of 1 mg/m3,8-hour TWA, for tha 'respifabie' portion. Measurements are based on samplingearried out using a C f Casells ske-selective cyclone sampler and the 'respirable' portion, to which the limit of 1 mg/m3,8-hour TWA, applies, is defined as that fraction of the dust which passes the cyclone and is collected on the filter mem brane. Other non-siTfcaous mineral dusts The value adopted In Great Britain for such dusts containing less than 1% quartz, is 10 mg/m1 tots! Gust, or 5 mg/m3 respirabl dust, Perchioroethyfene The ACTS reviewed the avaiJabfemedical and scientific evidence and accepted the view that the existing TLV of 4 SC-UK-MS-000109 100 pom, B-hour T,VA. provided adsousis prelection in the light of existing information. Since ?hn the ACGIH has published, in the 'Niticeof intended Changes' (pT5) 3 oroposai 10 >ow*r vjb T4V 10 50 ppm, S-nour TWA. This will be kept under review. Pesticides There are a number of entries for pesticides which appear either under the trade name ofa proprietory formulation or under the common cherries! name of the active component, It should be noted that in every case theTIV given is that for the active component, Rubber sofvertr This entry refers to the American product. A product by the same name mavbe faund on the marketh Greet Britain, but the composition may differ from the Amer* Span product end information on safe handling should be obtained from the suppliers, Trich/oroethyiene Although a TLV of SO ppm, 0-hour TWA, is proposed in the NoofIntended Changes {page 15), the ACTS after reviewing the available medical and scientific evidence, recommended retention of the current TLV of 100 ppm, 3-hour TWA, which will continue to apdly. The matter, however. Is being kept under review. Vinyl chloride The standard published in the Code of PracticeH a ceiling value of 30 ppm and an 3-hour TWA of 10 ppm, allowing the! wherever practicable exposure should be brought as near as possible to tero corcentradons {see Vinyl Chloride: Code ofPractice forHealth Precautions). An SBCdirective on the control of occupationat expo sures hss been adopted by the Council of Ministers and consideration is being given to any consequential amendments to the Code ofPractice which may be necessary. The directive seta a Song term limitvalue of 3 ppm jmean annual value) and this is the standard which is now being applied. Substances which ere prohibitedin GreetBritain Manufact'ire and use of thefollowing substances is prohibited >n GreatBritain undertheCarcinogenicSub stances 3 ulations 1367: beta-naphihyiamine 4-aminodiphanvl Oanncins 4-nttfOblpbenYl also the salts ofthese substances, and any substance tontain!ng any one 0r more ofthese compounds, except where present as a by-product of s chemical reaction in any other substance in e total concentration not exceed ing 19V. Tbsirimportation into the United Kingdom is also prohibited under the Carcinogenic Substances {Prohibition of Importation) Order 1967. Threshold Limit Values for chemical substances in workroom air adopted by ACGIH for 1980 PREFACE: CHEMICAL CONTAvsnANTS Th?osho!b Itmit vailes refer to airborne concentrations of substances and represent conditions under which it is believed that nearly ail workers may be repeatedly exposed c/ay after day without adverse effect. Because of wide variation in individual susceptibility, however, a smail percentage ofworkers may experrence discornfort from some substances at concentrations at or beJowth threshold limit; a smaller percentage may be affected more seriously by aggravation of a pre-existing condi tion or by development of an occupational illness. Tests B'a available W. Occup. Med, 15:564,1973; Ann. N.Y. Acad. ScL, IS!, Art. 2:968.19681 that maybe used to detect those individuals hypersusceptible to a variety of industrial chemicals (respiratory irritants, hemolytic chemicals, organic isocyanates, carbon disulfide). Three categories of Threshold limit Values fTIVs} are specified herein, as follows: (a) Threshold Li-nit Value- Time WeightedAverage {TL V7W'.4^--thvm"-weighted sverage concentratior* for a norma18-itbut '>orkdsy or 40-hour workweek, to which nearly ail workarj may be repeatedly exposed, day after day, vricbnu? ad"wse effect. lb) Threshold Limit1/ehe-Short Term Exposure Limit mV-STSih--xhi maximal concentration to which work* er*. r an be expusad for a period up to 15 minutes coo.inupu&ly without suffering from {1) irritation, 12} ch r?n*c qr i.*reversible tissue change, or (3) narcosis of su f>ci*m decree to increase accident proneness, Impair Sfc'f rascue, or materially reduce work efficiency, pravtd*d :h at no more ?han four excursions per day are knitted, with at least 60 minutes between exposure pu< iods, s<"3 provided that the daily TIV-TWA also is not exceeded. The STEl should be considered a maximat allowable concentration, or ceiling, not to bs exceeded at any time during the 15-mlnute excursion period. STSIs are based on one or more cf the foilowing criteria: ID Adopted TiV* including those with a 'C or 'ceiling' limit. {2} Penn<yivania Short-Term Limits for Exposure to Airborne Contaminants (Penna. Dept, of HUh,, Chapter 4, Art 432. Pev. Jan. 25.1368). (3) OSHA Occupational Safety and Health Standards. 40 FR 23073, May 28.1975, (41 NiOSH criteria for recommended standards for oecu* p-*'ona? exposure to specific substances- The TWA*STl should not be used as an engineering design criterion or considered as an emergency exposure level (EEL), fei Threshold Lirmt Value-Ceiiing (TL V-O--theconcern tMro-> th at should not be exceeded even Instan ts *eovsiy. For some substances, e.g,, irritant gases, only one category, the TlV-Ceiling, may be relevant. For other substances, either two or three categories may be relevant, depending upon their physiologic action. It is important to observe that if any oneaf these three TLVs is exceeded, s potential hazard from tha* substance ts presumed to exist. The TLV-TWAs should be used as guides in the control of health hazards ana should not Paused as fine lines between safe and dangerous concentrations. Time-weighted averages permit excursions above she limit provided they are compensated by equivalent excursions below the limit during the workday. In some instances it may be permissible to calculate the average concentration for a workweek rathe? than fgr a workday. The relationship between threshold limit and permissible excursion is a rule of thumb and in certaincases may not apply. Th amount by which threshold limits may be exceeded for short periods without injury to health dependsupona number offactors such as the nature of the contaminant, whether very high concentrations-- even for short periods--produce acute poisoning, whether the effects are cumulative, the frequency with which high concentrations occur, and the duration of such periods. All factors must be taken into considers* tion In arriving at a decision as to whether a hazardous condition exists. Threshold limits are based on the best available informa tion from industrial experience, from experimental human and animal studies, and, when possible, from a combination of the three. The basts on which she values are established may differ from substance to substance; protectionagainstimpairmantof health may be ^ guiding factnr for some, whereas reasonable freedom from irritation, narcosis, nuisance or other forms of stress may form the basis for others. The amount and nature ofthe information available for establishing a TLVvaries from substance to substance; consequently, the precision ofthe estimated TLV is also subject to vsrlation and the 1stest Documentation shouid be consulted in order to assess the extent of the data available for a given substance. The Committee holds to the opinion that limits based on physical irritation shoufd be considered no less binding than those basui on physical impairment. There is increasing evidence that physical irritation may initiate, promote or accelerate physical impairment through interaction with other chemical or biologic agents. ^Copyright 5979 and reprinted vwm the parrmss'cn of die American Conia/enca of Governmental Hygierxsts. 6 SC-UK-MS-000111 In sore of th? !sct trst ser'ous ;niury >s not belie'"** iikfiiy mixtures of two or more sucsisncss. A ariefd.s-uss.-n as j rtsu><C'> exposure fo Lbg ifl/esholct limit concentrations, tbs best pract'ce <s to maintain concentratiorisof of basicccnsiderat:nns involved in developing threshold limit values for mixtures, and methods for therr develop all atmospheriCContaminarHsesiow as ispracticas. These limits are intended tor use in the practice of ment, amplified by soecific examples are given rn Appendix C. industrial hygiene and should be interpreted and applied only by a person trailed in this discipline. They ar* not intended for use, orfor modification forusa.fi) as a reJ.fr/vtf index of hesarO or toxicity, 12) in the evaluation or control of community air pollution nuisances. 13) in estimating the toxic potential o? continuous, uninjer. rupted exposures or other extended wort; periods, (4) as proof or disproof of 3ft existing disease or physical condition, or (5) for adoption by countrieswhose work ing conditions differ from those in the United States of America and where substances and processes differ. Nuisanceparried*tes in contrast to fibregenic dusts which cause scar tissue to be formed in lungs when inhaled in excessive amounts, so-called 'nuisance' dusls have a long history of little adverse effect on luRgs and do notproduce significant organic disease or toxic effect when exposures are kept under reasonable control. The nuisance dusts have also been called (biologically) 'inert1 dusts, but the latter term is inappropriate to the extent that there Is no dust which does not evoke some cellular response in the lung when inhaled in sufficient amount. However, the lung-tissue reactioncaused byinhatation Ceiling us Time-WeightedAverage Limits Although the time.weighted average concentration provides the most satisfactory, practical way of monitoring airborne agents for compliance with the limits, there are certain Sub of nuisance dusts has the following characteristics; (1) The architecture of the air spaces remains intact. (2) Collagen (scar tissue) is not formed to a significant extent (3) The tissue reaction is patentia)ly reversale. stances for which it is inappropriate. In the latter group Excessive concentrations of nuisance dusts irt the work are substances which are predominantly fast-acting and room air may seriously reduce visibility, may cause whose threshold limit is more appropriately based on unpleasant deposits in the eyes, ears snd nasai passages this particular response. Substances with this type of (Portland Cement dust), or cause injury to the skin or response are best controlled by a celling 'C' limit that mucous membranes by chemical or mechanical action * should not be exceeded. It is implicit in these definitions per $e or by the rigorous skin cleansing procedures that the manner of sampling to .fetermine noncom necessary for their removal, pliance with the limits for each group must differ; a A threshold limit of 10 mg/m3, or 30 mppcf, of total dust y single brief sample, that is applicable to a `C limit, is not <1% Quart*, or, 5 mg/m5 respirable dust is recomappropriate to She time-weightedlimit; here, a sufficient mended torsubstances in these categories and for which number of samples are needed to permit a time* no specific threshold limits have been assigned. This weighted average concentration throughputs complete cycle of operations orthroughout the work shift. limit, for a normal workday, does not apply to brief exposures at higher concentrations. Neither does it apply Whereas the ceiling limit places a definite boundary which concentration . -hould not be permitted to exceed, tha ?ime*w.f>ohted average limit requires an explicit limit to theexcursions thatare permissibleabove We listed to those substances which may cause physiologic imp airment at lower concentrations but for which a threshold limit has notyet been adopted. Some nuisance particulates are given in Appendix 6. values. It should be noted that the same factors are used by the Committee in determining the magnitude of the velue of the STELs, orwhether to inciude or exclude a substance for a 'C listing, Simple asphyxiants--Inert'gases or vapors A number ofgases andvapors, when present in high concentra tions in air, act primarily as simple asphyxiants without othersignificant physiologic effects, A ?IV may not be 'Shin`notation listed substances followed by the de signation 'Skin' refer to the potential contribute n to the overall exposure by the Cutaneous route Including mucous membranes and eye, either by airborne, or more particularly, by direct contactwith the substance. Vehi cles can alter skin absorption.This attention-calling designation is intended to suggest appropriate measures for the prevention of cutaneous absorption so that the threshold limit is not invalidated. recommended for each simple asphyxiant because the limiting factor is the available oxygen. The minimal oxygen content should be byvofume undernorma/ atmospheric pressure (epuivalenuo a partial pressure, pQ, of 135 mm Hg), Atmospheres deficient In 0? do not provide adequate warning and mps? simple asohyxiants are odorless. Several simple asphyxiants pre -r.' an explosion hetard, Aceount should be taken of this factor in limiting the concentration of the asphyxiant. Specific examples are listed in Appendix P. Mixtures Special consideration should be given also to th application ofiheTIVs in assessing the health hazards which may be associated with exposure to Physic*/factors It is recognized that such physical factors as heat, ultraviolet and ionizing radiation, humid. 7 SC-UK-MS-000112 fly. atno^oi prsss-'s latitude) a^o theiike rnay place added st'sss on the body so tti^i the effects from exposure dt a threshold limit may be altered. Mo st of these stresses act adversely to increase ihe toxic re* sponteof a substance. Although most threshold limits h3ve built-in safety factors to guard against adverse offsets to moderate deviations from normal environ ments, the safety factors of most substances are not of such amagnituos as to take care of gross deviations, for example, continuous work at temperatures above 90"F, or overtime extending the workweek more than 25%, t Hjht be considered gross deviations, tn such instances judgment must be exercised in the proper adjustments of the Threshold Limit Values, Biologic Limit Values (8L VsJ Other means exist and may be necessary for monitoring worker exposure other then reliance on the Threshold Limit Values for industrial air, namely, the Biologic LimitValues, These values represent limiting amounts of substances {or their effects) to which the worker may be exposed without hazard to health or well-being as determined in his tissues and fluids or in his exhaled breath. The biologic measurements on which the BLVs are based can furnish two kinds of information usefuI in the control of worker exposure: (1) measure of the individual worker's over-all exposure; (2) measure of the worker's individual and characteristic response. Measurements? response fur nish a superior estimate ofthe physiologic status of the worker, and maybe made of (a) changes tn smountof some critical biochemical constituent, (b) changes in activity of a critical enzyme, ic) changes In some physiologic function. Measurement of exposure may be made by (1) determining in blood, urine, hair.naiis, in body cissues and f?uids, the amount of substance to which the worker was exposed; (2) determination ofthe amount of the metebolite(s) ofthe substance in tissues and fluids; {3} determination of the amount of die substance in the exhaled brash' The biologic limits may be used as an adjunct to the TLVs for air. or in place of tham. The BLVs. and their associated proceduresfor determining compliance with them, should thus be regarded as an effective means of providing health surveillance oftheworker. VrhstsO ic/bslances Many subs':rces ciessr.t c- ha<%% led m industrial process*sdo not aocseif ori the 7|_V iist. in a number c( instances ine macenai is rarely present gs a paniculate, vapor or other airborne contaminant, and a TLV is not necessary, in uther cases sufficient informa tion to warrant development of o TLV, even on a tentative basis, is not available to the Committee. Other subst ances, of low toxicity, could be included in Appendix 6 pertaining to nuisance particulates. This list {as well as Appendix P) isnot meant to be ail inclusive; the substances serve only as examples. In additiomher are some substances of not inconsider able toxicity, which have been ommed primarily because only a iimired number of woricers (e.g.. employees ot a single plant) are known to have potential exposure to possibly harmful concentrations. 'Notice ofIntent' At th beginning of each year, proposed actions of the Committee for the forthcoming year are issued in the form of a 'Notice of Intended Changes', This Notice provides not only an opportunity for com ment, but solicits suggestions of substances to be added to th list Th suggestions should be accompanled by substantiating evidence. The list of Intended Changes follows theAdopted Values in the TLV booklet. Values listed in parentheses in the 'Adopted* list are to be used during the period in which a proposed change for that Value is listed in the Notice of Intended Changes. Legalstatus TheThr&shoid Limit Values, as issued by ACGIH. are recommendations and should be used as guidelines for good practices. Wherever these values (of whatever year) have beers used or included by reference in federal and/or State statutes and registers, the TLVs do have the force and effects of law. Reprintpermission This book is fully protected by copyright and no part of it may be reproduced m any form, by print, photoprint, microfilm or any other means withoutwritten permission from the American Confer ence of Governmental Industrial Hygienists. Inc,, P.O, Box 1937, Cincinnati, OH 45201. 3 SC-UK-MS-000113 ADOPTED VALUES " ~~ '" ' '--p< A J- -IVTT* VC- * .. T* ^ * *-"i > . -- ----- At3ie Acsi-'d^vcs A;-:-cJcct........... C A4ft' c anhycrce . . r Ac;one . .. Acd'2nilAI .......... Acetylene ........... ICO )p s <1.0001 AO ? to 130 25 20 2.4CQ1 70 _ 150 15 _.. 1.2501 50 -- 20 270 37 .._ I3.CCCI 105 Acetylene c-c^or-ds. see l.2*Ocn:cfcri^yin* 200 780 250 1COO Acetylene tstra-romide 1 t5 1 5 20 * AcetylSS'iC/l'C 9ca CASDinnJ ................... ._ s-- _ Acrolfin ...................... 01 0 25 03 03 Acrylamide--Stan .......... _ 03 -- 06 rj J-crytori.tnle--Stan ........ (Albi (Alb) -- Aiacn --Start ................. -- 025 -- 0 75 AiM jicphO*--Stan ........ 2 5 4 10 Allyt enter'd*................. 1 3 2 6 AiM glyc>Sv1 ether UGSL-Skm............... AJMsropvtCrSgiFICe ....... 5 22 10 2 t2 3 44 IS Aiumsrvym metal and Oxide ....................... . -- 10 _ AJyrrunium pyropowders -- 5 -- 20 -- filuirurwm wtfgivgftjmss Aluminum, soluble salts Atumsirum, a^ryis (NOGS Aluminium oxideiAl*Oj) S --Stan .. -- 5-- -- _ 2_ -- _ 2-- -- -- E -- 20 -- Alb -- Alb 2-AmihoeM`ianol. see Etnanosamine ............ 3 3 6 2*Aminopyndine............. 05 2 2 3'Amino-1. 2 4*uioie A2 A2 -- Ammonia...................... 25 13 35 15 4 -- 27 Ammonium Chsonde-furne............ -- 10 _ 20 Ammonium Sylfamact (Ammatel ................. -- to -- r-Amyl acecstt ............. 100 530 150 seeuVnyr acetate .......... t25 670 150 20 600 eco * A-line & rgmolc^uas-- Sta*......................... 2 10 s 20 AniSiC'f* !>. C-iSOm#r$>_SWrt ....... 01 05 -- -- Antimony i compounds (Sbl ..................... _ 05 -- -- Antjmcny tnoxid* hanidmaf*5ys.......... -- 0.5 -- -- Antimony tnotaCe crcovcucn -- A2 _ -- ANTU tai**#oftffiyf thiourea).................. Ajgoo................... -...... -- 0.3 f_ -- F 09 P Ars?rvC & solute axrpcoAQilasAS) -- --, 02 __ -- A/3r*te tnotad* production.............,... -- 62 Arsine ..................... . oos 02 -- -- -- -- *t Asbestos. see Mineral dusts........... Asphalt ipeuoleum fumes) Awrine .................... 4iinpnos<<netfTYt--Skin -- Are --5 -- to -- 0.2 __ AH -- 50 ---- -- 06 Sarum (sofu-Pfe comwunda), (as 8*1. . 9avson <prCK3ourt........ * Saytex. see Fenthkm ... Bancmryl .................... i 3enzena ..................... -- -v 1QA2 &5 05 01 to X.A2 -- _ -- _ 25.A2 -- 2 03 15 7S.A2 fj Beniidin* Production-- Stan ...................... -- (AIM -- lATW p>5eo2uqyincne. see au-ftwe.................. SenatM peroxide...... . O.t 04 0.3 5-- 12 -- $?':;,3iov>ene .. Benzy. cni^* ................ 3'prery* .................. S smuth telluric ..... &smutn tgwufde. Sedccod.................. Sorates, ?*y. sodium safes. AiViydffjS ............... Decelerate............. Penutiyo/ate ............ SAVo/tCtfOe ............. Boron tnbfwnide........... C 0omn fritigoride ........... Sfomec^ ................... . Bromine....................... Bromine pemaHuoride... Sromccbloiomeffiane (see chtorofcgmomethane Bfomofom--Sdn .......... Suaaene ft. Sautatfenej t Butane........................ Sutanethol, see Butyl mercaptan................. 2-flu43ncoe see Metfiyiethylkstone ^E........................ ! X'duToxvetnanoUSutyt ceSceotye*>--Ston...... n-Sutv^ Wetite.............. see-Butyl acetate .......... terX'Butyt acetate.......... BurylacP^ata................. C n-Butyl ateotvst--SXin ..... T sec>0ury?8icohG*........... mi*8uw alcc^ci........... C Butyiamine--Sltin......... SC cfrwmts 1st CiOj)--Skm............... 1 r-Sutyl gvccM e&>ar(0(3i nBur^ lactate............... BuM mercaptan ............ * o-sec Buryi ghenol --Skin................. p-tsrt^utyitfftjene......... CaomiHjrn, dust & salts (as caj.......................... C Cadmium oxide furne las Cdi ......................... t Caorraumoxideproduction bsCtS...................... Cadum cartwnatetrnaftfe Calcium cyanamtde........ Cateumhydwi'de......... CaMum oxide................ Camphor, synthetic........ Caprolactam Oust......................... Vapcr........................ CspaTof fOiWecen f-- Sten.......................... Captan ........................ CartanrffSevn*) .......... Cartc<ursn IPuradan^... Ciftxsn obcR.................. Caraerdiode.............. * Carton esuL'ide--Sun... Cahcon mcnex*ia......... Carbon teuaWomice...... t Carton tstncWoride--Stan...... Carbonyl chiomie ('pMjjerref................ r Cartonyi ftjonde........... i --C 02 .... -- -- _ -- -- 1 1 1 0.1 Ot 2CO 05 1.000 (ECO 05 200 rso> 150 200 200 10 SO (T50I ICO 5 _ iso; s OS 5 10 _ _ _ _ _ -- _ 2 __ 5 -- -- _ -- 3.0TO 10 50 U.r m a (5) A2 l -- 2 A2 -- 15 05 IS _ 5-- T 5-- 1-- 10 -- 10 3 3-- 10 2 07 03 07 03 A2 _ ...i X 10 -- -- -- 20 30 -- 20 2 2 ,030 250 1.300 ---- .200 1.250 2.7SO 430) (750) (1.780) i5 -- -- sso 300 965 (24Q) 710 5S0 550 55 esa (450) 3 IS 01 1270 25 '5 20 63 OOo ocs IA2J E 05 5 2 12 1 20 (1501 200 250 250 _ _ 150 _ -- -- -- _ 20 -- --. -- -s. -- -- 3 -- 10 [7201 950 1,133 1 IX _ -- -- 450 _ -- -- .-- -- 120 02 -- -- 20 1 -- -- IS 1 40 0.1 S 5 0.1 35 S.COO X 55 -- -- -- -- 1 S.COO -- 4CO 03 -- 15 10 -- 7 27 .COO 4 m i20l itOOl 0.4 -- (155 -- -- Capita* letters retar Appendices. Reference*lal to Ipl. 2 rc 5 SNa otherwise aass^ed. i g 22. *i90 Adamon. lSee Nonceof intended cmr-ges jSsernttedgCtco. oo t*mm '*iiiii`iiii.iii`ii>WT^. SC-UK`MS-000114 S.;; j^v -. ;-r . , \f -5 -- r ....... :r~ -c -- :.. ..i C^ecrci '^"jcj'-jc-iod 5 <v _. Ceivcsa ts'j -- -- CoS'um hyC'3*~e --2 Cr,r53'*i?--S<." -- 06 -- Cn'or.'.red ca . 5km -- 05 -- Cmcrm-ated dpf'er&l o:de -- 05 -- Cfrm* .................. 5 0 3 CMorne d'OxiCe . ... 01 02 03 C Cmorne "fluoride .... 01 04 -- C C*ior030?f39"V"a 53 _ 20 _ 2 C.cicne^and .......... ? C.fo,'e*3i'ir" C,cchaxene ................. Cyc'o^eiry!intino--Skm . 2ZO '2Ci '2CC1 3CO 1 0'S JO 40 % $ 2 C'r?t=nite_S:n ....... 15 3 Cvcicceruadiene . . 75 200 150 4C0 2.4-D (2.4.0ichJorcoheno*y 9 acetic acvB ............... 10 29 09 ODT (Oichtoro&Ohenyl' _ tr^t^oafnap^ ....... _ DOvP. see D'CNar/os-- 1 3 a-Chiprceee'.cph.e'icne |Ph9naCYl cniorde) .... * Ch'-proacetyi cnlonde . . Chiorobencere CCS 005 03 02 _ _ ,, Skm................ Oecatorane--Stan ........ Cemeicn *--Sdn ........ O'acatone alcohol 01 0 05 00) 1 03 03 0 15 0 1 0 03 3 09 03 (Mcroch/oroceraene).. 75 350 _ _ l^-hydrd/V'A'fnethy^ t o-Chiorcb9n?yi.cene meloncniirla--Skm .... (0 05) (0 4) -- _ 2*pentanori8l ............. 50 20 75 360 1. 2-Oiamince(han9 see CNorcbromomethane .... 200 T.05O 250 1.300 Ethyienedtemine........ 10 25 * 2-Chior>i, 3-0utadier. Cistmon--SWo............... 01 see &-Chfcrcprene-Skin 10 35 _ _ Ciacemethene............... 02 0.4 OKorodif'uoromethsne ... 1.000 3.500 1 250 4.375 C'borane...................... 01 0 t CJiiofcd'Chenvi (42% r i. 2-Cnbrcmoeihane see Chicrmei--Skin .......... _ 1_ 2 Eihyiene dibrcmide 03 Chlorodiphenyf (64% Oiicrme)--Skin ......... v-- 05 -- --Skin.................... (Alb) WISH 1 Oibrom*...................... 3 $ 1-Cnloro-2, 3*ecc*y* 2-n>Dinuty1aminoeth3ncd propane (SoicNorohydr.nl --Ston ....................... 2 e$ C 2-OiiorcecnancJ (Ethylene cteorohydnnl--Skin..... 1 3-- *t Chioroethylece see Yiny4 cwonde............. 5Aia -- --Skm ...................... 2 14 A 28 20 D*uV choidhate.......... t 5 2 10 0'butyt c^it^tete............ _ 5 -- C DidniQrscetyfena........... ot 0.4 _ 10 c CXcNorcaenjene......... 50 300 rrfr L._l. _ frOichtorcoenzare........- 75 450 110 575 Chloroform 3. 3'-CJChioneri2:dine (Tr.chionjme'.nane)..... 1CA2 SD.A2 50 225 --Skm....................... _ A2 A2 Bis-CWorpmetnyl ether ... 0001 Ale _ Ala CchiorDdiduoromethane 1.0C0 4.950 1.250 5.20G r 1-Ch*or>t*0(trooroc'ane ... (201 (100) -- __ 1, 3^ichJon>5, CMoropicrn ................. 0.1 0.7 03 2 5-d;rnethytfiydenTs3m.... _ 02 -- 94 * S-Chicrcprene--Skm .... to 36 _ _ 1,1-C*h$oroethane........ 200 0TO 250 1.010 o-Cflioroscyfera............. 50 285 75 430 i 2>C4ch)orQethane, see o-CNorotoiuene--Skin .... 50 250 75 375 2 --*..oro S-i(rchioofrs^.vi| pynSmelN-Serve ).... -- 10 _ 20 ChJWDyTifOS (Oureban Skin...... _ (Ji _ 06 Ethyienetfchior-de..... 1. 2'0'cn(dnoeihviene .... O'Chloroethyi ether --Skm ...................... D'CNcrofiuerorretnene................... 10 200 5 10 40 rso 30 4C 15 60 1.000 10 50 --_ ?t Chromates, certain r C'Ctiorcmethene. see m.icfycie 'arms ......... --(0 05-Alal -- (Alai Merhyiene chicrde.... (2C0! (700) (2501 (3701 `7 Cn.x.r' c ^c:d and CrrcTriBS^ntf...... _ (0.09) __ c i, lEfchJortM- ._ miroethane............... 10 60 _ _ Chromite ire proceamg 1. 2-0*ch!wcorcoane. Icnw e.:^f (as O) ..... 3.05.Ala _ _ see Propylene ; Chror:i\,m, Sol. chromic. chrcrrous safes (asO) 05 dicNonde................... _ QichJorcflr^aene--Skin ... 75 3SO 110 t i !0 5>Q 50 Clopdoi tCoyden)......... Coal car ph volatiles (as Serwer.e solubles)...... t Cobalt metal. dust and fyme las Co).............. Copper fume................. Cysts & miststea Cu) Corundum (AI?Oal.......... t Cottondust raw ........... Crag * herbreide, see -- to _ 0.2.A1* -- (O.tl _ 0.2 _t _c -- 02* -- 20 2, 20<chteropn?onorac e&d.......................... t 6 -- -- Ala 0%h)croteua^uoroethane 1.CC0 7.CC0 1.250 3,750 0<ch(orvjCOVPl--Skin 0.1 T 03 3 _ Osrotoohos (Bidnn ^ _ --Skin....................... -- 0 25 _ __ 2 OevcIopeMaOiene......... 5 30 _ -- _ E Oicvclocentadienyl iron ... 10 -- 20 -- 06 Oit^dnn--Stan............... -- 0 25 _ 0 75 t Oethylarmrre................. (2S) (75) -- -- Sodium. 2, Oiethyterrdrwetfiartol 4-3ic."itcrooh9nory --Sfen .................... . 10 50 _ -- ethyl sulphate ............ _ 10 _ 20 Dtethyiene tnvnine--Skin 1 4-- _ Oesol, aii isomerv--Skin 5 22 w. Diethyl ether, see Ethyl Crotoraieahyde............. 2 6 5 16 ethW ........................ 4C0 1.200 500 1.2C0 Cr-*orri^ * ................. _. _ 20 Dethyi ohmaiate ........... _ 10 Curnen^--Skin .............. Cvanarri'de.................... S_O 2*5 2 75 ___ 36_5 Dil'ourocSjromometharie tC Dietvodvl etherI0C5).... ICO (0 5) sect (3) ISO 1,230 -- ,~ Cyanides (as Cttk--Ska>... _ 5 -- Dihydroxydenzene. see I Cyanocan ...................... 10 20 *C Cyanogen chloride......... 03 06 -- _ -- _ Hydrodumcne...... ..... Diisotxjtv* ketone .......... _2 25 150 -- -- A -- Cyc&oekane................. 300 1.050 375 1.300 Dnsopropytemihe--Skin 5 20 -- -- Casual tetws :e`.>r ia Appendices. References (a) to (pi. see 3 22. * 1960 A*i<i'ort ?$ee Notice of intended charges tSee in 2 to a otherwise classified. s 10 SC-UK-MS-00011S D ?i*st"cry~*,t'isre sc Me:-y* Ch'**et'*yl SCtvtam.Cd-$**n D'^tinvwr.rs . Oime th.yiji~i"*|C'2(`.icris i COO :0 50 3 ICO 35 19 J.250 15 -. see Xyi.d.ne--Stan 3 25 10 Omsiny'ani'ne (N. N-D-mothyianiiir,*^ Sfc.n Omeyvdeivgrie see Xylene--Stan . . 5 25 '0 ICO 435 150 OimaiKyicarpamyi chlonee ................ A2 A2 -- ChmetPyi-i, 2-d:brom>2* dxtMorpethy^ phosphate. jeeD.prcm 9 ..... ...... _ 3-- Dimeyry^onriamicJ*--Skirt 10 30 20 2. 6-0rrrethyv^heptanens. seeDiisocufyi ketone 25 ISO 1.1 'C"rretnviKyorine -- --5tan ...................... 05A2 Oimetnyiphthaiate......... _ 1.A2 5 Oynechyi sjipKste--S^'n Q.IA2 0.5.A2 1.A2 _ -- Dtrujctanxe^e CaU isomers^--...... 0.15 1 05 Dinitroo-eesol--Sion<*... -- 02 -- 3, 5<]iitfCH>>toio*^-3e (Zoalene*)................. D/nnmoi'jM--Su*?...... Oioxane, tech, grade --4tan ...................... ._ <K) s 15 090 _ -- _ Oiothort iOefnav *) Skin........................... _ 02 _ O.ohsrryl. see B'Shenyi... 02 1.3 0.8 Oidi-enyrsm>ne ............. _ 10 -- C o.-eny^mathane Crjocymate. see Methane t>sprt0fiyi drsoc.?ite(MDI)..... 0 02 0.2 -- Dipropy^wde 8!rtOl Ocver......................... ;co 600 ISO ,, 05 Oaec-cctyi phtr-ettfe 10-2ethyihe<yl- ththaiate) ............... it --> DiuKursm.................... _ 2 -N. Oisjifotsn iOisvston*) -- 0.1 ,,_ 1 ^tert-our/HxieMt _ . TO ro -- --1, Oi'.nyt 2gn:?e............. 10 so Oy*onats Sjn........... _ 0.1 Emery.......................... _ * --. -- SnCosvJfen (Thicdart *) --5*n....................... fno'rwv--SJwrt ................ _ 0.1 _ 05 _. , E&cbWOhydrifw-Skin.... EPN--Sw................... 26 -- 0.5 -- t. Z-Epoxypropane, see Fmpysneoxide.......... ncct am (150) 2. 3-Eso*y-i -p/enct seeGNcidoi............... Ethane......................... Ethanstr.oi. see Ethyl mercaptan................. SthicKHN'elats')--S*jn .. 2"S,JYd,'*0ofc"lStan ... ISO) f os 3 _ {MS [TW 8 0.4 4370) (7S) F 2 8 -- (150t ^ecnoxvWV *r* (Ceitas-ive acscata)-- Skin............... ......... Ethyl acetate................ Etryi actviate--Stan..... "-./ aiconoi (SthanoB... C;>V4frjr,................... {too* fiCO (25) 1.000 10 (5401 1,400 (100) 1500 IB (ISO) -- _ -- 1: -,i em^ ketone )5 M*tf\yihpU*ooe)... 25 130. --> 3 875 SO -- SO 50 6K _ 8 SO _ 2M 10 -- 3 08 10 s -- _ 4 20 -- SCO 1 to 5 0.3 20 _ -- 20 03 03 20 2 (360) (225) _ 3 15 _ 15601 i810) -- _ _ -- -- ?:'^;eri2re .... ICO 203 katone C-r-Mianoner .. .. 50 Ethyl chfcnde. 1.000 Ethylene..................... F C E;n-,iene cNprohyenrv-- Stan......................... fi,."iyiene d'amine * 5tV##d*W!cw ... 1 10 (Ally * rmylar* d-cr-jorce. see 1.2'Dcrioroerhane ctnyiene glycol P&ticutate.................. 10 -- t vapor ....................... Itco) rC Ethylene glycol dinitrate ar<aw Nitrogtycenn --Skin ...................... Etnytsne giyccJ methvf ether acetate (0 21 (Methyl cefioacrwe * acecatei--S`on............ t &frifet*eaxice ............. 25 m Slh>$enir*ine--Stan....... EWiyi ether................... OS 4( Ethyl formate................ 100 Etnyf.cene chtaHcie. sea 1. vDicNOMUhan*.... 200 C SttiyiidenenoiComene... Ethyl mercaptan............ t N-Ethytmorphoftne-- 5 G5 Jdn ......................... Ethvl siScata................. Feosuifothion (Oasann!.... {* to _ Fentmon....................... -- faraarn... .................... Few-anedium dc...... FlucndstaeF)................ -- -- -- Puenne ........................ t t fiuoTptnchforomethene. see Tnch'ofcRvoro- methane................... {1.00 C Formaldehyde............... 2 Fonriam:fle................... 20 Focri(c*6d................... r Pj.-f.Ls*--Stan............... T- Furtur^ alcohcd--Start. ... 5 151 (5) t Gas3':e....... .............. -- CcrTnanyum tecrahydskW Glass, fibrousordost* ... 02 __ C Glutarattehyda............. Gccemmsst ............... 02 -- 1 GtydO^ (2. 3^poxy^ 1-twpanoOv.............. > GMxi mwicetfty* ether. (50) see 2-Ethox'^ethano)-- S'tn.......................... Graphite (Syntheec)....... Guthion * see Aamphos-methyi--Stan (100) -- -- Gypsum....................... Hafrytam....................... Keium............ ............. Heorechwf--Sttn.......... -- -- r -- Heptane In-Heptane)...... dCO f Kaxachtorobotadiene..... KeochlorocvWoasnt^ A2) dtane....... ................ f Hexachiorcethene--Star, 001 111 nexachtcrpnaphthelene --Stan....................... -- Hexafljoroaoetone....... o.t t Hexane (n-nexane)......... (ICO) Knamethyt pnosphor> irnije--Stan............... A2 425 890 2*J0 2.SCC _ 3 25 {Aial 40 10 (2SO! 125 250 75 1.250 F _ _ IS _ 1125! 12) -- 120 35 ;S 1751 1 .203 500 200 163 910 250 25 -- i2 iS5) -- 35 30 3.1 _. 01 -- '0 -- 1_ IS 22 5,600) 3 30 9 (20) -20) IB2] 08 10 0.7 E H 250) __ 30 . ITS) noi -- 0.6 -- -- -- (ISO) (75) 1370) E 02 5 OS -- 05 1.600 (All 01 (10) 02 0.7 zsa 42 1150) -- _ -- _ F -- 500 -- D 03 !3; -- 03 1T2S) -- j-5 1.1*0 2<i 3.250 _ ... _ 50 20 (325) -- 170 |133 -- 1.500 450 WO -- 3 -- 255 -- 03 20 3 -- 4 (7.000) -- 45 _ (SO) (0) (62) -- -- c (225) (SSO) 06 20 }S >- 2 2,000 -- UJ 1301 09 2 (650) -- Capital :8?:8fs x*fi to Attendees. References is) to ip). m p.22 >930 Addwn fSee Notice orwuneed changes. tSea iwreducw. (M 2 to S. (Not oihenM&s clashed. V SC-UK-MS-000116 v,.S J"T# j*..,1,: +r.-4"r k* --...---- ---------------i . . - . ---- * see Methyl n*p-j?yi .ercna--Sk./i ' He*ors. see v*:hyi scPutyt ketone-- S'cn sc-r-iefyi acetate . .. . i- "S'^r'lef'95lvC0l Hydraair.s--5'iin . Wydrig-an Hydrogenated ttfphenvia Hydrogen b'O^sJg . C Hyphen chloride C Hydrogen cyornae--Skin Hydrogen fierce ( r| Hydrogen pe/cwce . .. . Hydrogen setervee las Se[ Hydrogen syifsSe .......... HycL'CQuiirorie................ Z-HyCwyOfODVl severe Skin .......................... indene .......................... indium 4 Compounds fasJn? ....................... C koine ........................... Iodoform.................... Iron oxide fume 're Qj) (Fe)........................ f Iron onuearbonyl (as F*j iron salts, soiutfetas Fe) Isoamylecstaia.............. laoamyi aidonol............. isoDutyl acetate............. Sscthitylakohd ............. C too^tvcr.e ............ Isophorone drsocvanate --Sim....................... Isopropylscerote ........ iscsropyl alcohol--Skin... isoproDylamine............... ' N-scpropyi andr.e - Skin....................... Isopropyl ether............. Tsopro*) ed'w (IQS).......................... Xa&ui ........................... Kec-e ....................... Lead, '.-.erg. fumes & dus;j(as Pbi............... r Uadarsewo'3t.`..... 5 Laid chromate (as Cr?.... Lm^stone .................... bri*Oiv--Gicn ............... lithsum hydride.............. IPG U-yuefied petroleum gas)......... - Magnesia..................... Magnejtum oxide fume (as Mg?....................... Waiathr.-u-Skjn............ Maleic,yihydro*............ C Mango. .eae & co^oQuiiOslee Mr) ... Manganese fume (as Mn) Mrv^nese cycdpentedienyl wcarbonyl !as Mn) --Sfcn ....................... Manganese tetrox-de..... calcium ootCcnate.................. Mercury (Alkyl com- pounds)--5fcn (as Hg} r Ma'Cury (Alt forms except aflcyi; <js Hg).... f Me*rvl oxide................. Mstnan*....................... (25) (ICO! (ICO! 50 25 0? A2 F 05 3 5 10 3 1 0 05 10 _ |10) 300 125 0 1 A2 -- 5 TO 7 10 25 15 02 14 2 05 3 10 45 _ 0.1 0.1 1 06 10 33 {0QT1 ICO ICO ISO 50 6 5 10 031 T 525 360 700 T5<J 25 0.01 0.09 250 950 400 380 5 T2 2 10 250 1.050 50 240 _E 05 0.9 _ 0.T5 --> ioia _ 005.A2 _ 03 --- 0.02S 1.000 -- _ __ 0 25 _ _ 1,800 E TO 10 1 5 f rL 0.1 1 f.L _ 0.01 -- 10.06! (251 (1001 P-- ,*C) (125! ... -- _ F _ _ -- -- 6 2 15 _ -- 15 __ -- t _ _ 125 125 T97 75 _ _ 310 500 10 5 31O 75 _ 15 _ -- _ _ _ '.250 _ __ _ _ TT/1 _ __ ? ;; cS.1 i5!0! -- -- _ -- 5 3 -- 21 A 70 03 -- 20 10 't 553 450 875 22S _ t,185 1.225 24 20 1.320 360 20 3 0 45 (C i3J 20 13 2.250 20 __ _. 3 03 20 0.03 (0J5J -- Sea MeU-iyi meroaotan . . . Meti'o^y) tlannjte *j --^Sk.fj .. Methorychkir .............. 2-Msthoxyetf'jnou--S<m 05 ... 1 23 ro (M*i/j cefissoive 9!. . Mthyi acetate............... MetnyH acetytene IpropryneJ Methyl acetylene- 25 2CO 1CCO 80 510 1 650 prapMiene mixture (MAPPJ ............. Mediyi acrytare--Sbrt .... Methyl acrytonitfiie--Skm Methyl (<Jimethoxyn*'ethefie!.... Methyl idnhoi 1.COD 10 1 uxn ?aco 33 3 3.100 {meihav30--Sbn........ 200 260 Metn/amme................. TO 12 Methyt smyt ^conoL see Methyl isobutyl caromol--Sim............ f Methyl fremyf ketone 25 ICC l2<Hept9rtCM5) ............ t Methylbaowe--Sk*n ... t fcfettiyf butyl MW*. (ICO! ('51 (465) (604 (25) (1001 Methyl celtosgM *-- Sw.iaJ. Methcwyethanol........ Methyl cetoso've * acetate--Sod see ethylene gl>cof monomtvyte?rvfef weta'A ... t Methyfchfande ............. Methyl chtorofotm 25 75 HC0I 60 '70 1210? i. 1. 1TncMlOrfr ethane)................ ..... Mediyl 2-^a>acryl0te... Merhyicrcbbexane........ Methy*cyctohexan....... dMethytcyciahexanone 350 T.3CO 2a 400 1.600 50 235 --Sinn....................... MettiyKydopehtadierTyl SO 730 manganese tncsrtonyi {as Mn)--Skin............. Me&iyidemens'--Skin.... _ 02 -- OS C Methylene brsphenyf dnsocyarate IMOI) ..... t 4, 4'-Methy4?ne Bs OC2 02 (2-ch4ofara4ne!, MbOCA --5Vm....................... 0 02^2 022A2 C Methylene bis (4<ycl> hexyKsccyar^te)......... 001 OH t Methylene eWanae IdicWcromertiane)...... * 4 4' Methylene dianiline..................... Methyt ectM keicaie (MEW C Methyl ethyl ketone peroxide..............-..... Methyl TaTnate.............. C Methyl hydrate --Skin...... ................. f Methyl odide--Skin....... f Methvfisoamylkotone .... Methyl iscdutyt cartund --Skirt ...................... (200) 01 200 0.2 TOO OZA2 151 000) 25 (7001 08 z&j 15 250 035.42 (28) (475) ICO t xtewyl ^sobutyf ketene --5Wn....................... (1O0) (4>0J Methyl isocyanate--Skm 002 O.K MethyJ memapon......... 0.5 1 Methyl n eftacryfate...... ICO 410 Methyl caraffiicuv--Skm ... _ 02 Methyl propylketone .... 200 700 ?C Methyl sdioate............... IS) (30? 25 250 1 2SO ! 250 2 T.250 250 40 (150) _ (40) 35 35 1125) 450 d 500 75 75 _ _ -- -- _ (250) 05 300 -- ISO _ (10) (TSOI 40 (125) -- -- 125 -- 2SO -- 120 760 2.0*10 ?250 s 3 875 310 ISO ('10) I f 63) 120 '.70 r>i 2.450 16 2.0CO 350 34o 05 15 -- -- -- 1870 4 ses _ 375 _ (58) 17 TO ieo (510? -- -- 510 0.6 875 " S3 'ettere -V*r :o Appendices. Pefatencts (a? w (pJ, see p 22 * 1*80 Aodfion. tSee Notice of intended changes. tSee (ntrcouccco. CO to 5 UNot ocnenMse classified 12 SC-UK-MS-000117 iy-j .. s y * - >' < * ~.'r 1 ~a-!" I-'&Iyy> 1... ^ rC stv'er'o MciYCdsnu-m '.as Mo? HOW idSO! Phenyl gJycCyl atri*r )7 so 'JO Sci.Cie comcunCS InaduCe CCmcoyncis _5 10 Pns-^fryCrsrns--Si^i . 5 20 !C ... 10 _ 20 Phenyl metcaetan 05 2 .... _ Mcmccnj'cpros !AiOdtin*l _ 0 25 -- ___ C PhenylahMohir.e ... DOS C 25 --. _ r Mor'crnei'tyi ar-hne--Skm 12! 191 (4) 08) Pncrate (TV/net !--Skin _ -0C5 _ 02 McrphCl'ne--Sin * 20 70 30 105 Phosdnn (Mawinonos *i Machih|3|ep................. t S'NscKnv'afr.y-e ?o 50 _ Alb ?5 75 _ A!b --Skm...................... Phosgene (carecnyf 005 ftJ DD3 02 Neon ........... F _ f __ c,*iio3e) ................... 01 04 -- _ N.Cka) CarhonyMas Ni) 0 05 0 35 _ Prtostihine ................... 03 04 1 1 Nckeimetai ... _1 __ PhcSDhoric acid ............ 1-- 3 N'.cker. sd-decompounds Phcschomusiyeiiovv) .... -- 01 -- 03 CasW ....................... or _ 0.3 Awsohc*;s Nickel suiWe roaseng. pefnachJQnde............ 01 1-- -- <umearic! Oust las Ni).. _ iAta _ _ Phosphorus ctmasulfiQe _ 1-- 3 Nicowie--Sn............. _ 05 -- 1 5 t FhoscMrusvichdMe ... (0.5! (3) -- -- Niincacid...................... 2 s4 10 Phitr^ficarihvCrde.......... ! 6 4 24 Ntoc o*kle.............. \... 25 30 35 45 m^hwaiodirutrile .......... _ 5_ _ D-SitroanrSne--Skin '...... l S 2 T2 Ploar?/7Often 9}........ )0 -- 20 1 5 2 10 Rakacid--^Skin............ -- 0.1 '-- 03 p-N>ttWiiorcenzrie-- Pwa^(jflvayM.3- Skin .......................... t 4-NitrWis>honyi.............. r . Aib 2 _ Ale indanfianet............... Paste*of Paris ............. 0.1 --E 03 20 Niuoethene................... ICO 310 ISO tC Nitrogen dioaifie............ ffJ 191 -- 458 __ Fkatnum (Scftjde sails) tasPQ....................... -- oaw -- Nitrogen tnfluond........ 10 30 ts tC NitrcgMJenrv--Skin........ (0.2) (2) -- 4S _ PoVwfembi(^en>ls. see ChtooCgKen.yts--8km __ -- Niiromethen*............... 100 250 150 275 r i-Nitropropane.............. (25) m (35J 035) PoiylH'afHiorgettryiane dacomposlfeon Dfoduds -- B1 __ 8) *C 2*NiCM0'OC8ne .............. 2SA2 9QA2 r^iiceodmethyterTyne -- _ C Potissumhydro*do..... Aooane................ -- A 2-- c -- IdimettryiniKcsoamifte) Ptopergyl alcohot--Swi... I 2 3 6 Skin .................... _L/ A2 _ A2 t &-Prtspiacrane ............ -- M) -- CA2) r N;iroioJuane- Skin........ (51 1301 (101' 180) PrtOfomc aw)............... TO 30 15 45 N<trotncwefem,,,han. see Chftrcpcnn ...... Nonane ....................... 0.1 0.7 2CO 1.050 0.3 2 m (,303 rvPropyl aceiate............ 200 840 250 1.0SO PfOBylatohcd-ASkin...... 200 500 250 625 r'-Ph^fftrCtSW.............. 25 40 470 Qctacn4cionapd\alene --Skin ...................... _L_n O.t 3CC 1.450 _ 0.3 375 1.500 Propylene..................... Prooyiene dichionde (i. MNchlcrocracane)..... P-- p 75 350 HO -- 510 Oil mist mineral ........... 5'" Osmium teiroxide (as Os) 0 0002 0.CC2 OOOC5 50 rC Prcoyfene ^ycol dinitrate 0006 -Skin ...................... (0.2) (2) -- Oxa'cac.d ................... 1-- Z PfOtm#*9 g>YC3f 0*yg"d'hL>or?de ....... 0 05 01 015 0.3 moneTiethyletMT___ 100 360 150 0 1 02 03 0.8 t Pic&ytene imme--Skin .... (2) (5) -- 540 -- Parson wa* fyme.......... 2 6 t Prr4ene ode........ . (1001 1240! (1501 (360! Parapuat respirable sires 0.1 __ _ Pn^yne, see Parethion--Skin............ _ 01 -- 0.3 Methylacetyene........ 1,000 1,550 1.250 1040 Psrticdace ootvcydic arrjmacic hydrocarbons ftwsswr.................... fVkhne........................ 5_ 10 5 15 10 30 IPPAHi see Coi tar pitcr vdattce......... Pentaborwie.................. Penacnloronaohihatene --0.2, 0 005 Ala 0.01 0.015 05 _ Ala 0.03 2 Qurnone....................... 01 04 0.3 ROX^sae CycWite --Sun....................... -- 15 - Resorcinol.................... 10 45 20 1.2 3 SO PentacWctophenol--Sktrt Periae/yiMiw............... Pentane........................ 2'Pnntanone. see Methyl fA-- C.S E eoo I.8CO _ ?5 t Ftecriw*, meuJ sr>G 20 ?so 2,250 dusts (as flh).............. SolublesaltslasRh) .... ftohnei......................... _ 10.1) -- (OCOU __ to -- (0 3) -- (0023) ---- propyl ketone.............. 200 700 250 875 Rosin core solder pyrolysis _t Perr'foroetnytene--Stort (100! (870) (150) It 000) products (as Percntoromethy* *wwaftbyde}........... marcaptan................. at <k6 Rotenone (commercial)... PercMorytfluonde.......... 3 14 6 28 S^ouoe.......................... Phenot--Skin................. 5 19 10 38 t Pubbar solvent (Nashua) 0.1 Ie 6 OQ 1,600 _ -- -- 0.3 10 20 -- Phenoth-atin*--Stan...... S __ 10 Selenium compound! (as N-PhenY^betd-naphshvleT'ne ........................ A2 A2 D*Phor*yl4"e diamine-- 0.1 St)........................... Se*vum hwanuonde i)iSei....................... >''nn#(seeCarOarvl)..... _ 0 05 02 02 5 " 10 Phenyl ether (vapor!....... 1 7 2 r Phenyf ethe-&pbeny( m'Khxeiv^pwt.......... (1) m 12} f Pheoytethylene. see Styrene monomer...... (100} (420) (125) Id ltd] 1525) r . seisesSGcon laoetiyttnde).............. S>..... .................... Scpn ca.rpide................ f Slicon teuahyOnde tSitana)...................... 05 -- -- (OS) 0.7 6 8 10.75 1 15 -- -- 20 m 11 5) C&5-S lateen reler to Appendices. Penances (al ipi. see p.22. i930 Adeton rSee None* ofiniaided change *See[nvoew-w so 2 to 5. Wot otherwise deasifiea. 13 "I )| TIi ' I ' l.i. i----------------------- SC-UK-MS^000118 * S..vr THAI * S..vet _ 01 _ CG*r-ZC-~*32 (4S Agj . c Scd".~ ''J .......... Scd..m 2. ' sICr^POCMorvs^V* __ 0i -- toon 03 o _ _ sity s- *.ne . *........ Sodium r-..*xcscetate (1060)--Stan . . . c Sodium m,dioxide ......... Sodium meUJbsSoitite .. . Suren Stib'^e ............... t ptcddera solvent ......... Strychn'f'e.................... r Styrene monomer -- __ _ -- -- 01 (1001 -- 10 0 05 2 5 s OS (575) 0 15 -- .._ 03 (1253 _ (Ptienyiethyiene) ....... (1001 1420) (125? c Suacl'i.ris (PratecNiic enrymee as 500% pure crystalline enzyme)..... Sucrose....................... SuMur dioxide................. Sutfur rexeflucnde ........ $uunc acd................... -- 0 00003"* -- _ e __ 2 5S T.OCO s.coo 1.250 _ 1_ Sulfur monocTJcnde....... 1 6 3 Sulfur peoafiuoride........ Sulfur atraftuonde......... SulfuryJ fluonoe ............ Systo*, see Oameroo *-- 0 02S 0.1 5 0.25 0.075 0.4 03 20 IQ Stan........................... 2,4,5-T ........................ Tantalum....................... TgDP--Stan................... 0.01 lsri _ 0.1 0.03 10 -w 5 __ 02 _ Teflon * decomposition presets ................... _ Bl _ Teflurnim & compounds (agTe) ....................... 01 . ... Tellumjm hexaituonde (aaT#) .................... 0 02 0.2 ^w TSPP--Stan ................ -c y.--...... 1, 1, 1. 2-7cri.ro/o-2, 2<<rtiuorot'''ine ........ 1, 1, 2, 2'Te& ichioro-i. 2-ditfuorcvhine ... . t 1. 1,2. 2<r`i'nchloro 0.M4 05 KO see O.OS 5 4.170 1170 0 01 625 S2S emane-v 'ft................. p Tet'acnioroe'nyiene, see PeraHiomethylene-- (51 (35) (103 Stan ......................... ? TB,'-c.-(crc.-.ethene. see C i `on :a"'icPiioride-- (1001 1670) 1150) Te'<?cflioronacnthsiene TewMthyfle^S 'as Pb) --Sfcn............................. Teira.-v-rofuren.............. TetrrK-iechyf lead (as Pb) --Skin............................. Tetrame'ryi succmonifnle -Stan ................... Tetrer-iromepiane........... TeTiesaTnjn p/rcchaschafe Tatty (2 4>&tnratf& c#io,i*mefhy1riufamin| Stan ....................... Than'um. sc^.ibi* CCrrpnunds '*1) S' -........................... 4.4*Tr-'^'i ,o.Jart' bur.' -- < r-^ai)............ Tlv^-. ._:caea................ Tfcryn* ...................... t Tin `''Ajenic compounds. ev:,vt SnH,and SnOj (as r>l....................... 2 _ 0.1'* 200 590 __ o.is1" OS 3 1S s 15 ...u 01 __ 10 15 5 -- (2) __ 2SO 2 _ . __ -- _ 10 031 _ .... 20 0 13 _ 20 1S (7201 0 45 (525) _ 20 13 7.5CO _ Id 0.75 1 40 0.3 20 10 oe ei . 0.2 5.250 S.210 (70) (1.000) 4 0.3 735 0.5 9 _ 3 . 20 . 10 (45 " O'lpn.c COmpourdS iSSSni--Stan . ' > no-.deiasSnt -- 01 -- !5) 7.:p^.Trd.odeijsTit .. -- To-usne (tciucO--Stan.... 100 375 tC Toiuan^. d-dnsocyanaie (?0... t o-TolU'&ne ... Toxa-hene. sse Chlorine. (0 02) (5) (0 td| l22i ted campKene--Skin -H 05 T TrbuTvlpncspha'9 ...... -- (5) Trichloroacetic acid ....... 1 5 C 1.2, iTr^cfiio/cdenzena 5 40 1,1.1*Triph(0PO8^an. see Methyl cMore-form 350 1.000 1, 1. Z-Tnchlorcethane --Stan ..................... 10 45 tl Trchtoroetiylefie........... (ICO) 351 T T^ofitorolkioramethane ... (1.000) 15.600) Trchloromethane. see Chloroform................ 10. A2 50.13 Tn^iioronatSijhalene..... -- 5 5. 2,3-Tnchroropropene ... 1.1. 2-TncWoro-- 2. 50 3CO 2'idhuonoethane........ 1,000 7.600 Tncyc)oh#vil(n hytJrowja (PWran *) ,,,, __ 5 TrictP>ylarftne ..... . 25 ICO TnftuoroPramo- methane_________ _ 1,000 6.100 Tnmetftyl benzene ... . 25 125 f TnmetfWKiospfute....... (0.5) Z 1 >7RnitroDhenol, (2 Si see Picricaed--Skin ... -- 0 1 2,1 O-TfiniwcDhenyt- mecbylrritramine. see T&<rvk-5jn............... -- 1 5 ?C 2, 4. S-TrinitraToluene (TTfT?................... ..... _ 10 5) Trwrthocresy^ c^osp^l ' tr,D"ienylamine.............. -- 01 c TnpnenH phospfate___ Tungsten & compounds __ 3 (asVVI Soa-jb'e........................... irvioMjle........................ _ _ 9 5 Turpentine.................... 100 8C Ura^um fnaturel) sc(uble& rnsdubie compounds (as U) ..... t VanacSum, (ViOsJ las V) Oust.......................... C fume........................... -- 02 _ (0 5) _ iCGS> VakraWehyde................... 50 175 Vinyl acetate.................. 10 30 f Vinyl benzene, seeStyrene 1K30! (420 Vinyl brorrade............ 5A2 20J-2 *5 Vnyi cnlonCe,.............. . 5A1e. 10-Aia 11 Vln* cyanide, see Aciyfcrtitnie......... ...... lAtw lAlbl Virv cydchexene tSowje 10 60 Virv'denedrtonde........... 10 40 r vinyl toluene.................. VW&P Naphtha............ Warfarin............................. (100) 3C0 -- (4301 1.350 0.1 Wefdints fumes (NOO8.... __ 5. 93 f Wood dust Wonairergenic) Xylene, (o>, nv. p^somers) -- 3) --SNn ................... ...... ICO 433 C m-X,(ane q, a'Oiamme -- C! t XyWene--Skui ............. Yr^..,m................. .............. 2nn cnWde fume........... i ZirKchramatelasCr)..... Zinc oxide fume_______ 2nc stearate.................. 5 25 _1 --1 _ OCS. A2 --5 _S __ ISO (501 ._ -- 450 20 (150> (1.2501 _ _ 7S T.250 --m 40 1.200 35 -- -- -- -- J 50 _ _ 20 (125) __ _ __ 20 (1501 4CO _ __ -- ISO __ -,Q __ __ _ _ 02 i?0! 20 5c0 (44i 1 r -- 2,450 90 (BOOt 17.0001 10 4&3 9.5C0 10 160 7.3CO 170 -- 03 3.0 _ 03 s 3 10 $40 06 (1 5) _ 60 (5251 _ -- _ __ * SO (720) 1.600 0.3 63 not 650 -- 50 3 2 _ 10 20 Cental letters refer lo 4en<ce8. References (al to Ip) see p 22. *1980 Addition fSee Notie* of intended cnarsss :Se '-i'ce.cicon so 2 to 5 INvc a?netv.ise classfied 14 SC-UK-MS-000119 ~.u <>.< ,-'lit's* >;y P 3 --^ /'isn" NOTICE OF INTENDED CHANGES FOR 1330 liters -cmeouncs iasZ;! These substances, with therr corresponding values, Mineral dusts comprise those for which either a limit has been proposed for the first time, or for which a change in the Silica, StO/ CaYSTALLSNE Quara TUV 'ft mppcf ,m `Adopted' listing has been proposed, (n both cases, the proposed limits should be considered trial limits that will remain in the listing for a period of at leas? twovears. If. after two ytats no evidence comes to tight that questions % cua/u*lO TLV for respirable dust in m^nr*' IQmgrm3^___ the appropriateness of the values herein, the values will be reconsidered for the 'Adopted' list. Documentation is available for each of these substances, % resprabie quara*>2 TW for ''total dust'*, respraWe and nonrespirable: SttOstwca TWA STSl "com "rr&m3 3flmtyma Acetone...................... 750 1,730 1,000 2.37S Cdssobaiite Tnbymife %quenz-*-3 Use coo-half thevaluecalculated from thecount ormass formulae forquem Useone-halfthevaluecalculated from Acrylic acid................... *S AcryWiitnle.................. Ssnjidine--Skin............ Butane......................... Z-ButoxyetharcMSuM tO 30 1 Ala AS. Ata -- Ala SCO 1900 .. -- -- _ _ -- _ ... Siia. fused Thpcfi 'ormulaa for cjuwn Use quartz formulae Use respirable1*' massquart: formula Csilwolvs*}--Sea .... 25 120 75 360 sec-Butvl aicobet........... 100 2CS ISO 465 N-BuM gtyckMether tAMORPHOUS (20mppcW (BGEJ....................... 25 135 Cadmiumoxide Silkies!<1% <fvarctl production ....... ........ -- 0 06 _ _ I jAsoestos. Amosite Cnrvsotde Croeooiire Other fcrms SMqa M^eratwocf fiber Petite Porjand Cement Soapstone rttaic inonasbestform) ts'Vc{`.Breus!, use Asbestos*mit 0 5 fiber >55*irrVcc. ATa 2 fjbers>5rsvcs. Ala 0 2 fibers-Sttw/cc, Ala 2 fibflrs>5Mm/cc. Ate ZOmopcf lOmgfn3 30mcf 30 mppet 20 mppef (20 mppcfl Cartcrt tetrachlorde-- Sfcn................-........ Cerbonyf fluonde ........... *C o-Chlorobenpfkfene mateowumte.............. Chtoromethy*methyl other............. ,,......... t<hioro-t-nitrcpropane Chlorcpentaftuaroethane t Cnromiummeti........... t Chromium ill} compounds, lasCrt.... t Civqmigm (l*l) 5, A3 2 0 05 3D, A2 5 04 20. A2 5 _ 125. A2 15 _ A2 2 1 .COO -- A2 10 5,320 0.5 _ _. -- -- _ _ _ -- 05 -- tCoalDust compounds, (asCr)__ t C2vomiym(Vi) -- 05 -- -- 2 mg mJ Uesoirabie dust fraction <5% queraJ. compounds, as Cr if >5%ffjira, use respirablemass formula. Water soluble CrVt - compounds.............. -- 0C5 -- -- t Certain wetefinscfuWe Nuisanceparticulates (seeAppendix E) 30 mppef or to irngim314 oftotal dust <1% quarts, or, Srog/m* CrVI compounds........ -0 05, Ala Chremyl cftlecd*........... 0025 0.15 Clwsene........... ,,........ A2 A2 _ -- -- -- _ _ respirable dust. Conversion 'actors: Cobahmetal. dustji fume, lasCol ........... -- OC5 -- 0.1 .tippet x 353 MiSice*sartiCea percuCw: meter - particles Cyclohexanone............. 25 ICO 100 400 C*r* 2 Cvcropeniane................ SCO ?,720 SCO 2.580 - 2-Cfomcethane. see EB^ene flibramkle-- Skin.......................... AS A2 _ -- t. l-Oichforo?<nivoethane.............. 2 to 10 SO OethySamine................. 10 30 Diethyl ketone............... 200 7C5 25 -- 75 -- OglycicM ether GEJ.... O.t O.S -- -- Dtoxans, tech. grade-- Skin.......................... 25 SO ICO 360 Dipropyl ketone ............ SO 225 -- -- SnRurane...............-..... 75 575 -- -- 2<e-oxyatharot--Skirt 50 1S5 too 370 2-StnoxYethyi acetate (Ceitoscwe* acetate! --Sfcr...................... Etfiyt senate--Skin____ 50 270 5 20 ICO 25 540 too Capital letters refer to Appenices. References (a) to !ol. see p 22. i930Add'Can. rSe# Notice ofIntended cnange*. zSee 'ntrcdi.ct.cn. pp 2 5 iNo: otnerwise classified. . M 15 SC-UK-MS-000120 XiS'^'P _____ 'j_.A >i:-- ,J .,t 3.;, .T J- ` i "r- = orgn-'ce-- $.n A2 A2 2!nyr?:,ccl. -nOOr g ;j<vco! tr;j oO 0 02 Severeoide ......... ;o ! 2S 02 20 N ;^.>mo/pnoiin^''- Ski-' 5 23 F^rrvtjL-Skin 2a rortyV gicCncU -Skirt .... 10 40 hiasei'i-.a . 3C0 900 Siytdoi (2. 3*?cc*v- 1-Ci"CCsr4*J............ 25 75 Halcyon................. 50 4C0 Hexechforobutadiene.... 0 02. A2 0 24. A2 ^^sscrioto^^arrs-- SkKI .. .... 10 ICO hexane (ivHexars) ..... 50 190 (other isomer)........ 500 1.600 Hexene, see Methvt ijchutyt ketone-- Skin .................... 50 205 iron wntacflt'30fvl asPe CM OB iscccrjt alcowy............ 50 270 iwjiropoxyeihsnoi ...... 25 105 usad arsenate, as PbafAsOa!,............ . 0.15 Mercury (Au forms sxeset aikyJI--Skin, as Hg Vapor ................... 006 Ary inorganic compounds ............ _ Ot Mes'Voxde............. 15 6Q Metfieerys: aerf ........ 20 70 i'MeihOxvpftencJ........ .. 5 Methylrvarr.yiwtone (2'Hecijrtonel.......... 50 235 N-h/ethy aniline_"Skin .. 05 2 Wethy dromide-^^h 5 20 Metnyin-duryl ketone .... 5 20 M.'titvf --'Wide........... N(%:ry^ena chJonde 50 TG5 'd,ii:'rrl,oiorr*M'^.... 350 Metiv-tictfae--Skin .... 2. A2 10. A2 N'ethyt .soamyl ketone .. 50 240 Meshy* .i6g?y xetsna Skin ................. 50 205 Mutnyiisopropyl ketone 200 705 Mein/I plicate ........... 1 6 a-toefti'' sven?........ p-N troan^nes^Skifi ..... 93 240 --3 P'N.trcchrorcoe/uene-- Sk>n..................... 05 3 Nitrogen dioxide ......... 3 5 Mrrcglycerin ............. 002 02 t'Nitroaropane .......... 15 55 Nitrotciyere--Skift...... 2 11 ^eechtoroethyene'-- Skin..................... 50 335 Per-jilates. eik metal 43 5,0,................. 2 P*eny( ether--0'Of'sny< mixture (vaoofl........ Phany: giycoyi eter 05 4 'Pi Z-......... ......... 1 6 Phosp-ortjsaxychWnde 01 0.6 Phcsononjs (nchtonda ... 0.2 1 5 Piyerat'ne C'rtvdrocnloride....... >-5:.* ,m msrAi ....... 5 1 |3<Prc^ici&ctcne......... . 05.A2 1 5. A2 Pico/ er.e ofveotsrutfette 0 02 0.2 Prco'/ene *mifte--Skin 2. A2 5.A2 Propylene oxide......... 20 50 Shcoiym. metef.......... t InscWjQle compounds, ................. o.\ __ 0 04 __ 20 10 (5 5CO TOO -- __ i.OGO 76 0.2 -- 75 __ 25 -- -- 100 1 55 __ 100 5,A2 -- 76 -- 6 100 -- 5 0 0A 25 2 o.s 0.5 _ I. A2 0.04 --- ___ _ 04 -- 95 40 60 1.SC0 300 -- _ -- 3.6CO 300 0.16 -- 320 046 TTTI to_o _ 465 5 60 205 uw 30, A_2_ 300 _ 30 465 __ _ to 0.4 SO _ _ _ 16 3 3 __ _ 3.A2 0.4 _ -- _ <5i ' 3 'Ccr. --{V^lVi' S'lver. sol.cis Cftrr-|,,-I<s. las Agj . * S'CCdsro soi'/QiM . . Scyr^n-e. rrorc^e' teneny'eti-ysne) . . .. s -- too 50 2'Tsi'&inlofo0^are -Sfan....................... ' Tn. ?m o*,Ce & 'norggruc compounds. exctp: SnK4. (as $nt ......... ' O-ToJiCaie......................... Tuuene-J, d-dnsoeyarats fTO . ' 5-Toiuid<ne ..................... "nfiufytchcgphate ......... *S TVicniorpethviere ...... *C Tnoiiorofluofomwhene . Tficienit`canh,l^nce........ * TnmemyJpjiospf'ii ' 2,4.&.TnriitfOKituene OW-sta........... * Varedium. (asV?Ojk dust & fume....................... V-nyttofuene.................... W<xd dust, hardwcod las in furniture making)........................ * Xyi;diae--S*dn ................. 1 _ A2 0 005 2 02 50 1.CC0 0CC5 2 -- 50 2 7 0 01 =25 215 7 2 A2 OCd 5 2.5 270 5.603 0 04 10 0.5 OC5 240 1 to _ .ICO 100 5 _ 0 02 _ 04 i50 ___ _ S -- ___ ICO -- ___ 1.050 J25 35 4 -- 0 15 5 60S ._ 25 3 _ <65 -- Mineral dusts C-aitmacwwrtsanti, natural.......................... 1 5-mg'm3. respraoiedus: S.i'ca, amorphoirs...........6 n-yrn*. toraldust (afl sen-glee 3 mgr'm3, resoirsfile dust! <5rr.[ Ta'c {containing ro f*ers) >5 mocd or 2 mg/m3, resoirsbJe ffjst Ta'c |fiber<on.ningJ . ..3 PCrs;CC, A-Sum :n length Cs&tei letters refer to Appendices. Hef&rsncss (a? to (oh se 022. *1960 ACC.ccn. tSee in'/cductfla w 2 to 5 SNot .'issued. IS SC4JK-MS-0G0121 Appendices Appendix A CARCINOGENS The Committee lists below those substances in Industrie! use that have proven carcinogenic in man, or have induced cancer in animals under appropriate experi mental conditions. Present listing of those substances carcinogenic for man takes two forms: Thos* for which a TLV has bean assigned (la) and those forwhich environ ments) conditions have not been sufficiently defined to assign a TIV (lb). A1a Human carcinogens. SuInstances, or substances associated with industrial processes, recognized to have carcinogenicorcoearclncgenic potential with an assigned TIV; SoOsunca TIV Acrytonitnl.......................................2 ppm Asaestoa, artforms ......................... Amosrte........................................ 0.5 fiber>5^nvcc Oirysofts.......................................2 fibers>5ttirVce CnxiO&rts.........................,..........0 2 f3sefS>5#*flVce Other forms................................... 2 fiCers>5i*trVcc fcss (Chtaromethyil ether....................0 COT pom Chromiteore processingitfirqmatel OOSr"g,rr'g,{asCd tt:Mtsu^*omg,taTW4dusr 1.0fngvn3(asNti Coal tar pitchvefatiles .................... 0 2 mgfm3 (as benzene tokiWas) vtnytchlodde .................................... 5 warn 3 Anvc-l, 2. &.',rasc\e................ _ *!* A-5rrc,T''/tr'Cx^eorotlct.&r* . _ * Arjir-c ino* de production ..............-- T Berber's......................................... lOcom Bsruciiipyrene ................................-- BeiyiUjm ........................................... 2.0*g'm3 f| CjCmium oxrie p.'cducaort.............-- Carbon wracnioftde.......... -............5ppm CNcratorm ..................................... lOppm C*nloromethy< ether..........................-- i Chromates cf lead ardzmc(asCf| ...0 0$ mum1 3 3,-Cnlorweritdine.....................-- Oimeihylcafhemvl chtonde...............-- 1, '.Dimethyl hydrazine--Skin.........0 5 ppm Dimethyl suffaee--Si/n 0,1 ppm Sthyiene c&Cromtfe--SkJrt............... -- 4 HesachWiobuudlene.......................O.G2ppm Ke*ametfiyi phosphcramkJe--Skin -- Hydrasne................. ............... ........Q.t ppm t 4,4'-Methylene b*. I2<hl0fcani&ie)--Skin --............. 0.02 ppm Metfty hydrabne........... ............... 0 2 ppm Metfiyrioffitfe................................... 2own 1C 2-Nitropropane......... .......................25 ppm rtfvJg*odinietfryt*rnine--Skin____ -- r^hehvet^AhthsQmin8.......... -- Propane suitor..... ......................... ftPropictectone....... ................. " Propylene inline--Skin..................... 2ppm * o-ToMine.......................................... Vmyi bremda........ ................. ......... Spent Vnytcyclohexane dioxide................. 10ppm For the above, workerexposure by ail routes should be carefullycontrolled to levels consistent with the animal and human experience data (sea Documentation!, in cluding those substances with a listed TIV. Alb Human carcinogens, Substances, orsubstance* associated with industrial processes, recognized to have carcinogenic potential without an assigned TLV: tt AcrylOhatnt S 4-Ananodionenyttp-XenylaminW *? Bendeine--Ston r GitotometM metric ether t t, 2-Ofcwmoeihan* lEttrfiwaibcemidei t fr^achTryiamme J ANitrc^Phertyi A3 The Committee guidelines forclassification ofexp* erimsntafAf*(MAL catufoogens. The fcffowog guidetines are offered in the present state of knowledge as an aid in classifying substances in the occupational environ ment found to be carcinogenic in experimental animsls. A need was fait by the Threshold limits Committee far such a classification in orderto take die firstseep rrr developing an appropriateTIVforoccupational expo sure. For tha substances In 1b, no exposure or contact by any route--respiratory, $Mn or oral, as detected by the most sensitive methods--shall be permitted.Theworkershould be property equippedto ensure virtually no contact with the carcinogen. A2 Industrialsubstances suspect ofcarcinogenicpcttno'af for MAN. Chemical substances or substances associated with industrial processes, which are suspect of inducing ceneer, based on either (1) limited epidemiologic evidence, exclusive of clinical reports of single cases, or (2) demon* ttretioncfcarcinogenesisin one or moreanimal spades by appropriate methods. Determination ofapproximate threshold ofresponse requirement, in order to determine In which category to classify an experimental carcinogen for the purpose of assigning an industrial air limit (TIV}, an approximate threshold of neoplastic response must be determined. Because of praeticai experimental difficulties, a precisely defined threshold cannot be attained. Forthe purposes of standard-setting, this is of tittle .moment, as an appropriate risk, or safety, factorcan be applied to the approximate threshold, the magnitude of which Is de pendent on the degree of potency of the carcinogenic response. * 5 930 Revision or Addition fNonce of intended changes, S$e* introduction, op 2 to 5, SCgarett* smoiong tan ecrence rre .nccence of resonator/ cancers from this or others of these substances or processes. 11530 Adcpocn )7 . *a iatntatm>im^., t ................... . SC-UK-MS-000122 ?OOS'i ora'f.cai'tnresncidof^eooia&t.c rasponse. cosoge c seremarts sncuJd he less man logar- uhmic. This oaccmas particularly importanratievels greater than 10 pom !or corresponalng rng m3). Accordingly, afters range-finding gstermination has been made by logarithmic decreases, two additional dosage tenets ate required 'wnhin ihe1eveie of'affecV and 'no effect' to approximate the true threshold of neoclastic response. The second step should attempt to establish a metabolic relationship between animal and man fortheparticular substance found carcinogenic in animals. !f the metabo lic pathways are found comparable, the substance should be classed highly suspect as a carcinogen for man. tf no such relation is found, the substance should remgin listed 39 art experimental animal carcinogen until evidence to the contrary is fund. Proposed classification ofexperimental animalcardnogens. Substances occurring in the occupational en* vironmerit found carcinogenic for animals may be grouped into three classes, those of high, intermediate and low potency, in evaluating the incidence of animal cancers, significant incidence of cancer is defined as a neopiastre response which represents, in the judgement of the Committee, a significant excess of cancers above :ttal occurring in negalive controls. Exceptions. No Substanr,e is to be considered an occupa* tional carcinogen of am, practical significance which reacts by the respiratory ,*oute at or above 1000 mg/ma for the mouse, 2000 mg/m3 for the rat,' by the dermal route, at or above 1500 mg/kg forth mouse, 3000 mg/kg for tne rat: by the gastrointestinal route at or above 500 mg.kg/d for a lifetime, equivalent to about 100 g TD for the rat, 10 g TD for the mouse. These dosage limitations exclude such substances ss dit'xane smS tticMo'oethyiene ftoroconsideration a* carcinogens. Examples Dearie--rats, hepatocellular and nasal tumors from 1015 mg/kg/d, oral. Tnchioroethyien#--female mice, tumors (30/30 @ 900 mijkg/bi. oral. A3a Industrial substances ofhigh carcinogenicpotency in experiments! animals1 1 A substanceto qualify as a carcinogen of high potency must fulfill one ofthe three foliowing conditions in two animal species: la Respiratory. Elicit cancer from {tj dosages be low 1 m$/m3 (or equivalent ppm? via the respiratory tract In 6-7-hour daily repeated inhalation exposures throughout lifenms; or (2) from $ single intra- "*acheifiy stored ccsa n~i ; r-- carncui.'.te, Qf )iQi,;:d, per 100 mi sss of amm*: minute resoirator/vciume, Examples b-s-CbioromethY`e?h!r--malignant ^mors. rats. @ C 47 mg/m3 i0 1 ppm) >n 2 years, Hexamethyi phcspho/a/r.ioe--nssai squamous cell corcinoma. rats. @ 0 05 ppm. in \ 3 montrs Oft 1b Derma/. Elicit cpncer withjn 20 weeks by skinpainting, twice weekly a? 2 mg/kg body weigm or less per application for a total dose equal to or less then 1,5 mg, in a biologically inert vehicle: Examples 7.12-Dfmethyiben2(aJamhraceri&--skin tumors @0 ?2< 0.3 mg TO in four weeks; Banzotalpyrene--mice I2^g. 3X/wk for 18 months, TO 2 6 mg, 30.9% skin tumors. Oft 1c Gastrointestinal. Elicit cancer by daily intflka via foe gastrointestinaltract, within six months, with a six-month holding period, st a dosage below 1 mg/Vg body weight per day; tot*) dose, rat. st50mg; mouse, 3*5 mg; Examples 7.12-Oimsthylbenr{aJanthfacene--mammary ijrners irem : D mg5X; S-Wethyicholarithrene--tumors 3 j.tts from S mg in *, W^i'. SentofaJpyren*--mrce. S.9% leukemias, hem 30 bays TO 128 2 Elicit cancer by ail three routes in at lea? ;wo snimal species at dose levels prescribed for high or nvermeo ? potency. A3b Industrialsubstances ofIntermediate carcinogenic potencyin experimental animals. To qualify aa a carci nogen ofIntermediate potency, a substance should elicit cancer In two animal species at dosages intermediate between those described inA3e and A3c by two routes of administration. Example Csrbsmic add ethyl ester-- Derma*, mammary tumors, mice, 100%, S3 weeks. 5CQ1400 mgTD Gastrointestinal, various type tumors, mice 42 weeks, 320 mg TD Gastrointestinal, various type tumors, rats. 50 weeks. 110-930 mg TD, A3c industrial substances oflaw carcinogenicpotency in experimental animals. To qualify as a carcinogen of tow potency, a substance should elicit esneer in one anlmaf species by any oneof three routes of administra tion at thefoliowing prescribed dosagas and conditions: 9 13 SC-UK-MS-000123 ta Respiratory. El-cit cancer from (IS dosagesgreater than 10mg/cn*3 (orequivalent opmi "is {he respiratory tract in 6-7-hour, daily repeated inhala tion exposures, for 12 months' exposure and 12 months' observation period; or (2) from intratracheally administered dosages totaling more than 10 mg of particuiate or tiquid per \CO mI or more of animal minute respiratory volume: steels, also creating a 'elatively iow level of (vnu Ferrous shays also areart-we)dedin oxidi/i"? an ments which generate considerable fume, and c.;. produce carbon monoxide instead of ozone, Sue generally are composed of discrete parties of asphous slags containing iron, manganese, silicon r other metalIic constituents bependlog cm the aito*, system involved. Examples Beryl (beryllium aluminum sweats)--malignant lung tumors, rats. @ 15 mg/m3 @17 months: Bemidine--venous tumors, rats, 10-20 mgr'nr,@>l3 months. OR 1 b Dermal. Elicit cancerby skin-painting of mice in twice weekly dosages of>10 mg/kg body weight in a biologicallyinert vehicle lorstleast 7S weeks. i.e,, *1.5 gTO. Examples Shale Car--mouse. 0. T mfx50g5g TO S&dQsidn tumors: Arsenic trioxjde--man. dose unknown, but estimated to behigh. Chromium and nickel compounds are found in fu when stainless steels are arc-welded. Some coate f!ux*cored electrodes ere formulated with fluorid4 the fumes associated with them can contain sign: more fluorides than oxides, Seeause of the abova factors, erc-weldIng fumesfrequently must be te;individual constituents vvhrch acelikely to Se pees determine whether speciflcTiVs are exceeded, C sions based on total fume concentration are gene adequate If no toxic elements are present in weld: metal, ormataJ coating and conditions are not co, to the formation oftoxic gases. Meet weblng, even with prknldve ventilation, do produce exposures inside the welding helmet abc 5 mg/m3; thatwhich does, should be controlled. 1c Gastrointestinal. Elicit cancer From daily oral dosages of 50 mg/kg/day Or greater dunng the Appendix C MIXTURES ------ ----------- ---------------------------- -------------- ------- - lifetime of the animal. C1 rbrashe/d Limit Values for mixtures. When r.. Appendix S SUSSTANCES OPVARIABLE COMPOSmON B1 Polytatraftuoroelbylene * decompqsft/on products. Thermal decomposition of the fluorocarbonchain In air leads to the formation of oxidized products containing carbon, fluorine and oxygen. Because these products decompose in pan by hydrolysis in alkaline solution, they can be quantitatively determined in air asfluoride ta provide an 1ndex ofexpoaure. No TUV is recommended pending determination of the toxicity of the products, but air concentrations should be minima). 82 Gasoline. See Notice of Intended Changes. 03 Welding fume*--'Totalparticulate (NOCff TLV.S mg/m3. Welding fumescannot be classified simply. The composition and quantity are dependent both on die alloy being weldedend the process and electrodes used. Reliabie analysis of fumes cannot be made without considering the nature of the welding processand system being examined; reactive metals and alloys such as aluminium and titanium are arc-welded in e protec tive, inert atmosphere such as ergon. These arcs create relatively little fume, but an intense radiation which can produce ozone. Similar processes era used to arewefd more hazardous substances are present, their co effect, rather than that of either individually, sho given primary consideration, in the absence of fnJ tlon to the contrary, the effects ofthe different h? should beconsidered es additive. That is, ifthe su the fcihwlng fractions. exceeds unity, then the threshold limit ofthe miv should be considered as being exceeded. Cr Inbi the observed atmospheric concentration, and T, corresponding threshold limit (see Examples 1.lAb}. Exceptions to the above rule may be mad there Is a good reason to believethatthe chief a * * the different harmful substances are not in fact v but independentas whan purelyfocaleffects on. organs ofthe body are prbduced by the various c centsofthe mlxture. 1n such cases die thresho` ' ordinarily is exceeded only when st least one c' series, T? T* itself has a value exceeding unity (see Example Synergistic action or potentiation may occurwi' combinations of atmospheric So 'Trace Names: Aagofluon. fkjon, Haioix T$ft-n. Teiran. tNot otherwise classified, tv*i.j................... SC-UK-MS-dOO^d 3! ''"Li! Of .-d:V'di;2l'v Pbll'nriaLng or syndfQ'Si-c agens are no! n^csssarily harmful by themselves. Potentiating effects c* exposure to such agents bv touiss other than that cf inhalation is also possible, e g. (mijioed alcohol and inhaled narcotic (trichloroethylene) Potentiation is characteristically exhi bited at high concentrations, less probably at low. When a given operation orprocesscharacleristically emits e num'osr of harmful dusts, !umes, vapors or gases, (twill frequently be only feasible to attemptro evaluate the hazard by measurement of a single sub stance. in such cases, the threshold limit used far this suSstance shouId be reduced by a suitable factor, the magnitude ofwhich will depend on the number, toxicity and relative quantity ofthe other contaminants ordinarily present. Examples of processes which ate typically associated with two or more harmful atmospheric contaminants are welding, automobile repair, blasting, painting, lacquer ing, certain foundry operations, diesel exhausts, etc, ClA Examples of Threshold Limit Values formixtures. The following formulae apply only when the compo nents in a mixture have similar toxicologic effects; they should not be used for mixtures with widely differing reactivities, e.g. hydrogen cyanide and sulfur dioxide. In such case the formula for independent effects 11Ac) snould be used. 1Aa General case, where air is analyzedfor each component: Additive effects. (Note: It is essential that the atmosphere be analyzed both qualitatively end quamHatively (or each tompow* pment. In order to evaluate compliance or noncompitance with this calculated TLV). . 1 Example lAa Air contains 400 ppm 0? acetone (TLVs 1000 ppm) T50 ppm of sec-butyl acetate ffl,V=2Q0 ppm) and ICO ppm of 2*butenonefTLV"200 ppm}. Atmospheric concentration of mixture *400* tSG+100=650 ppm of mixture. 400 ISO 100 10O0 * 200 + =04+075+0.5=1.55 200 Thrasnold lim.t is exceeded. v>hC'!>/9f>usc:s iappmxsrrats sc . iu~; T** pe-csn' composition (by weign?) o' C.e Nqu..: m.xturo is known. thgTLVs of th constituents nvjs? be lis:ed in mg/m3. (Note: Inorcsrio evaluate compliance with tnisTLV, field sampling instruments should be collated, in the laboratory, for response to this specific quantita tive and qualitative air-vapor mixture, and also to fractional concentrations^this mixture; e.g,, 1-'2 the TIV; 1/10 the TLV, 2 x the TLV; 10 x theTLV;etc.) TLV 0f mixture = ,L______________________________ f_ + *6 + *c + TLV, TLV* TLVC " TLV, Example 1Ab liquid contains (by weight) 50% heptane' TLV=4C0 Rpm or 1600 mg/m3 t mg/m3s*0 25 ppm 30% methylchloraform. TLV=350 ppm or 1900 mg/m3 1 mg/m3O.20 ppm 20% perchloroethylene' TLV=100 ppm or 670 mg/m3 1 mg/m3s0 15 ppm 1 TLVof mixture 0,5 0.3 02 1600 * 1SC0 + 570 _____________ 1_ 0.00031 + 0.0C0S6 1- OOCOCO \ 1300 mg/m3 0 00077 Of this mixture 60% or (1300) (0.5) = 650mg'm3is heptane 30% or {1300} (0.3) - 390 ng/m3 is methyl chloroform 20% or (1300! (0.2! 260 mg/m3 is perchlcroethylene. These vafoes can be convened to ppm as follows' heptane: 650 mg/m3 x 0.25 = 152 opm methyl chloroform: 390 mg/m3 x 0 18 = 70 ppm perchloroethytene: 26Q mg/m3 x 0,15 * 39 ppm TLV of mixture * 182 + 70 + 39 = 271 ppm or 1300 mg/rn3 1Ab Special case where the source of contaminant is a liquid mixture and the atmosphericcomposition is lAc Independent effects, toreontgins 0,15 mg/m3 of lead (TLV, 0.15! and 0-7 mg/m3 of suIfu?ic acid (TLV, 1h assumedto be similar to that of the original material; a.g. on a time-weighted average exposure basis, all of the Sd2.v 0.15 0,7 1 0,7 liquid (solvent) mixture avantuany evaporates. \ r Threshold limit is not exceeded. SC-UK-MS-000125 C1B TLV tor mixtures o/minera/tfusts. For mixtures of biologically active mineral dusts me general formula for mixtures may be used. Appendix G CONVERSION Of MPPCF TO MASS CONCENTRATION For rrnxture con tajning go% nonasbesri form talc and 20% quartz, the TLV for 100% of tha mixture is given byr 1 2 + 2? 9 mppcf TiV of nonasbestiform talc ipure)*20 mppcf 300 300 TLVof avsnzteurerk 'loOmTo'= T7o *2'7mpocf Essential!y the same resuIt wilt be obtainetf If the limit of the more (most) toxic component is used provided the effects are additive. In the above example the limitfar 20% quartz is 10 mppcf. For another mixture of 25% quarts 25% amorphous silice and 50% talc: 25% quartz--TIV (pure)2.7 mppcf 25% amorphous siiic*--TLV (pure)=20mppcf 50% talc--TLV {pure)=20 mppcf TLV--------------------------- - 3 mppcf 025 025 05 2.7 + 20 * 20 The limit for 25% quartz approximates 9 mppcf. Appendix B SOME NUISANCE PARTICULATES laJ TuV, 30 mppcf or 10 mg/ms oftotal dust< 1%quartz or 5 mg/m3 rs ,3ireble dusL Ajvrnmivm oxide{AI.Oj) Caieum carbonate Caicum sibcata Cellulose (paper fibed Portend Cement Emery Glycerin rtssi Graphite IsyncheBc) Gypsum Vegetableoi mists (except castor, coshewcut. orsimda? irritant oils) Kaoim Umestone Magnesite Marble MsienawooffiDer Pentaervthmtf Plaster ct Pans SiKoxi SiRxncerbde Stare* Sucnne Tinoodo4 Titanium doxide Cnecxitfedust Zincsieaete Appendix F SOME SIMPLE ASPHYXIANTS!?) Acetylene Argon 6'v^ne tnane Etn/ene He&um Hydrogen Mein** Keen Prepana PrtSMen* Calculations for Conversion of Particle Count Concentra tion Iby Standard Light Field--Midget Impinger Techni ques), in mppcf to Respirable Mass Concentration (by Respirable Sampler) in mg/m3? 1 to 1587, Jacobson and Tombt derived an empirical retationship af 5.6 mppcf to 1 milligram of respirable dust per cubic meter of sir, based on 22 sets ofsamples, mostly coal dust. The following calculation results in an equivalence of 6.37 mppcfto t mg/m3 of respirable dust. Tnusf sn approximate raf/P of $ mppcfto j mg/m3 of respirable dust is suggested for conversion of TLVsfrom a count to a mass basis when the density and moss median diameter have not been determined, 2 Basie sssumptions: fa)Average density forsilica containing dusts * 2.5 gm/cm312500 mgftm5}. Pulmonary significant dust de* nsitles may vary from 1.2 gm/cm3 for coal dust to 3.1 gm/cm5 for Portland Cement. Silica densities vary from 2.2 {amorphous) to 2,3 (eristobatite and tridymite) to 2.5 (alpha-quartz) gm/cm3. (b) The mass median diameter fmmd) of particles collected in midget impinge?samplers and counted by the standard light field technique, andcollected in a respirable sampler is epproximately 1.5 ntn or 1,5 * 10"4 cm. This assumption is. ofcourse, quite arbitrary since the mmd of all dust clouds Is quite variable, depending Oft manyindependent parameters, strcA assourceof dus?, ageofdusteroud, meteorological conditions. ate. 3 Calculation: {a) vol, per particle-A/arrf3; r-O,75xl0~4cm s*d/3i?IO,75x 1C'4}3 -L77x10",lcxn (6) wt. per paniclevolx density =1.77x 10',3cm3x2.5x1O'mg/cm3 =4.425x 10** mg/penicta (c) 1 pew/e'/73=35.5 pert/m3 {since 38.5cu ft=t cu m) tC part/ft3-mppcf35.5x 10 part/m3 wt.cfl mppcf35.5x 10pan/m5x4.425xlO-9 mg/part. 1 mppcf"0.157 mg/m3 or 637mppdf*t mg/m3 of approximately 6 mppcf"1 m.g/m3. See Noece of intended cnsnges. tfi'efttbnsWp getv*een GrewTrecx ResoYaWe Oust Conesneaiw? antf M&get Impinger Numb*# Co/icenffsicn, by Mwr^y Jacobson ana T F Tomb. AiKAJ. 29. NcvOec 1987. fte/erences la) (, see p 22. 21 SC-UK'MS-000126 - ?Cf 'T.-Oi'}'. -J.SiS ,<es{*?ac-$ r*.r^Si sgi V' '^tis ol pai*i^clcs pe cubic i o' e< :as*0 on tmpinger samples counted by light.f;ia Techniques. 5vii:src# J.! CS iS'Qjl rpc."nojS G'StObSi'tt Ruseo i.i.ca Cvanz TrpymitS SCcai dust D.stomaceous earth. Inaturail G,'3Chiie irafuiaft ;M<a Mineral voci fber Nuisance particulates Fcnlaod Cement Soaostcoe Trpoir Cccn? no?MJM fa'*1 Vi*3' "`Ccc* m?*"1 70 13)f 161 1 5 005 0:5 3 01 03 3 0 1 03 1.5 0 05 015 (12) 2 Ml ! 5___ ..... 15 B.S) \%) 20 131 (6) _ 15) 10 30 (5) 10 30 (51 m 30 (5) 110) 20 (3) {& (31 0.1 {CHj (h) The parcentageof qoarinn the formula Is jho amount determined from airborne samples, exceot m thoselnstances in which other methods have been shown to be applicable. li} Both concentration and percent quarti for the acohca tton of this limit are to be determined from the fraction pasting a size-selector with the following characteristics: AerotiVranvc d.ameter ImM fun'tdens/rysgnare/se.'estor 2 25 3S 50 10 % cussrng 30 75 SO 25 0 unless otherwise speeded, respirable mass * presumed to equal approximately 50% of total mass. t AjI values :n parentheses represent newly calculated values based an *2w3lStt6a? 6 ft'Sptf*1 mgim, rescueWemass and /eso-aWe massS0% total mass i Seeliti\ttd\xtoripp1xo5. fj> Containing <1% quartz; ifquartz content >1%, use formulae forquartz. (k) Lint-free dust es measured by the verticil-elutriatori cotton-duat sampler described in the Transactions of the National Conference on Cotton Oust, J R Lynch, p 33, May 2.1370. References 0) As determined by the membrane filter method at 400-450X magnification (A mm objective! phase contrast illumination. Cal Parts ofvapor or gas per milllan parts ofcontamina;-5d air by volume at25'C and 760 mm Hg. pressure. IP! Approx!mi!* milligrams of substance percutsic ma:ar of air, {cl An atmospheric concentration of not more th an 0.02 ppm. or personal protection may be necessary to1 avoid headache for intermittent exposure. fb> <7 in diameter. {el As sampled Py method that does not collect v'apor. (m) Based ort'high volume'sampling, (nl `Resoirsble' dust as defined by the British Medical Research Council Criteria (1) and as sampled by a device producing equtveient results (2). ill T E Hatch, and P Gross, Pulmonary Deposition ana Reten tion of Innsied Aerosols, p 149. Academic Press, New York, New York, 1964, 12) interim Guide for Respirable Mass Sampling, A!HA As/osol Technology Committee, AIMA J, 37:2. *970, p 132. (o) When toxic impurities are no? present, e.g. quarre<l%. (f) For control ofgeneral room air, biologic monitoring is tp) As defined on p 6> essential for personnel control. Dacumennation of ThresholdLimit Values forSubstances in WorkroomAir9 A separate companion piece to the Chemical TlVs is issued by ACGIH under this title. This publication gives the pertinent scientific information and data with reference to literature sources thatvvere used to base each limit Each documentation also contains e statement defining the type of response againstwhieh the limit is safeguarding the worker. Fora tetter understanding ofthe TLV'sitfS essential that the Documentation be consulted when me TL^s are being used. 6nquiries concernsng the eveilabilrty of copies of Documentation ofThresholdLimit Values >or Substances >rr Workroom Airshould be directed to the Secretarv*Treasurer, American Conference of Governments! Industrial Hygienists.PQ Box 1937,Cincinnati, Ohio 452G1. 22 SC-UK-MS-000127 HSE publications Guidance Notes in the Environmental Hygiene Series Methods forth* Detection ofToxic Substances in Air' H2 Chromium - health ano salary precaulions IH4 Aniline-- hestth and safety precautions EH 5 Trichloroethylene EH 6 Chromic acid concentrations in air EH 7 Petroleum based adhesives in building operations EH 3 Arsenic - health and safety precautions H 9 Spraying of highly flammaaie liquids SK1Q Asbestos - hygiene standards and measurements of airborne dust concentration EH 11 Arsine- health and safety precautions EH *2 Stibine- health and safety precautions 6M13 Beryllium - health and safery precautions SH14 Level oftraining for technicians making noise sutveys H 15;B0 Threshold limitvalues SHIS Isocyanates: toxic hazards and precautions EH 1? Mercury- health and safety precautions EH 18 Toxic substances: a precautionary policy EH 19 Antimony- health and safety precautions EH 20 Phosphine - health and safety precautions EH21 SH22 Carbon dust: health and safety precautions Ventilation, of buildings: fresh air requirements 6H23 Anthrax: health hazards EH 24 Oust and accidents in melthouses SH 2S Conon dust sampling Booklets describing simple and rapid means of measur ing low concentrations in the atmosphere 1 Hydrogen Sulpivda 2 Hydrogen Cyanide Vapour 3 Sulphur Dioxide A Benzene: Toluene and Xylene. Styrene 5 Nitrous Fumes 9 Phosgene 11 Aniiine Vapour 13 Mercury and Compounds of Mercury 17 CfvomicAcid Mist 18 Ozone in the Presence of Nitrous Furnas 19 Hydrogen Fluoride and Other Inorganic Fluorides 20 Aromatic Isocyanates 21 Iron Oxide Fume 22 Copper Fume and Dust 23 Acetone 24 Ssopherane 25 Zinc Oxide Fume 26 Cyclohexanone end Methyicyclohexanom The above booklets are obtainable from any branch of Her Majesty's Stationery Office or through any bookseller. Methods for the Determination of Hazardous Substaneest MDMS 1/30 V"HS2'8t MDHS3'81 MOHS 4.31 MDHSS'Bt Acrylonitrile in air, laboratory method using char coal adsorption tubes and gas chromatography Ac'v':-*-!'e i n air. Laboratory method usi ng porous polymer adsorption tubes with gee chromatography Generation of test atmospheres oforganic vapours by the syringe injection technique. Portable apparatus for laboratory and field use. Generation of test atmospheres of o'gan-icvapours ty ihe permeation tube method. Apparatus for labors'cryuse.t Omsise validation of sampling methods.3 See p3 under'SemaUng and analysis' fOniy available from me Health arc Safety Execvtrve. Jin preparation 23 t,rtri "rriin-x^^^f .............. SC-UK-MS-000128