Document kQrJ6mqa1MqXpkOvkm7d961b

DownloadSearchable PDFRandom document
. The Shanghai Health Study Patsy Clegg 0IaIJ. ()oe!1Ignt CCmmItl.. SiIoII~1J' May 2004 What is the Shanghai Health Study? !II AIong-telm dinlcal study to investigate the potential causes and development of Iympho-hematopoietlc diseases (diseases of the lymphoid organs, blood and bone marrow) as related II! benzene . o A projett of Fudan University MedlCllI Center; University of Colorado Health Sderu::es Center; Applied Health Sciences - an independent U.s. researdl firm; Chinese publi~ healtil agen<:leS; and Shanghai hospitals Benefits to Industry ~ Set sdence-based standards to protect worl<:ers and general population from benzene-induced disease II Mobile source air toxlcsstandards II Water quality standards . G Site remediation deanup standards '0 Corporate responsibility and product stewardship A , .. Shanghai Health Study Purpose 0To gain a Quantlflable understanding of the relatlonshlp between benzene exposure and potential. associated cancer risks Path to developing the study: o ~97: .. 97: o 98-110: .. 0.: o 01: Benzene ~ IIS$OdaI<ld WIth AMl mNO J)I.tlIlshed ~ 0lIna study that: ...."""""""--..,. 8INIMelII' CIUR! NIiL :.;...,~-- . __.......__It;_Ni:JIIettto(IoIOgyo1IIdled fOSll:lillty lIIUdleS In SIlar9ha1 Auslnlilan Il\stltuIl! oIl'eoc1eum', {AlP) .... ..- """""*..,...........,.,.Health Walc!1 Study 1io_wIIIHHL .. ......,"'IlenzeIle Health Reseatth COnsoroum formed W: -lNi"MII'qUl'lSt::k::lMf1I~~I'tSSXln_~ Benzene exposure and canQf!r Conclusions from pre-J997 Epidemiology ~ Only acute myelogenous leukemia (AML.) associated with benzene ~ No ri9; at expo$IIres < 1 ppm " aear risk at expos~res :> 20 ppm " Insufficient data at 1-20 ppm to assess list; HAZ-SHA-000279 ; ~i _ The Shanghai Health Study 1. pse Conlrn! Slu!N Traclltmal, prospet\:IYe epidemiology stI.dy 10 delBmlne risk or~!., NHL among benzene I!>qXJSEd wori<ers - 450 ~L and 450 NHL pi!!leOts --'10 stIJdy 2. DI<eag Prrm:ssJro 5lI!dy I>ro>pettIve sb.dy on reIotianshlp d non<anrer bone """""" dIoe.al;e and benr.... Irlduced AML Uniqueness ofShanghai Study o prospective research ~ Patients at participating hospitals suspected of . having a lymphoid, blood or bone marrow disease wlU be referred to the SHS . = Patients' diets, environmental exposures and fi\mlty histories wlU be recorded ~ Patient disease progression followed at supporting hospitalS Uniqueness ofShanghai Study c Study will be able to examine primary diagnOstic and medical data in real time q) First-hand exposure reports are more reliable than second-hand or reconstructed Information Q) State-owned databases document worker histories Uniqueness ofShanghai Study o Robust data set = State-maintained benzene exposure and health effects databases documented from 1970s " senzene related health effects are II 2 II reported chronic occupational health hazards in Olina In 2001 (SoINre: JiIN..rryIfpub/c-_IIh) " Large range of exposure levels from a variety of occupational sources C Regulatory authorities Interest in improving benzene exposure regulation and . enforcement Quality, Independent Science I) All protocols reviewed and approved by external Institutional Review Boards (IRB's) Govem use 01 human S>iecI$ U.s. m 0I1na Irdepetodentty o SIIangnal Heelth Study independent review panels IntJ:miltlona! Ethlc:5 _ Panel Intemallonal Sdendflc _ IZ members . PiIneI 6 SClend!\c disciplines Involved dtn1ng ....tInl projeCt jRedacted : 'j :...j HAZ-SHA-000280 2 Benzene Health R.esearch Consortium Organization OVersight Comm'tt~ /"" t I'~ Tectr1C!111Budget commutation Recruitment Legal Sdent!flc ~ PaM! Shies RaIIIeW Panel N'CO Shanghai Health Study StudY partldpa!JlS Poindpll "'~ tDrr.. _"".,.,wtiomnoid. _. u.. __ _...... _ _ CeoUf CCIh......_ , Q. Fu HIWI, hOI" U"iIItr5I1 _ _..........., -_Un..-....,S<-bm>Id_OI_Pa1tidpllllls: 2(, .... ~_k MIIftI<lpoICaIIa''''' _ _ SN~ sn.!1QIWI"""""_"" _ _ Su~ Un_."'"~--....... tntImIll\eIoM -.Is UdCOi>oodo. __ . Shanghai Health Study Study lime Une Aug 01 31'1Q01 2002 3Q03 Aug 03 4QOJ Aug 04 2007/8 Consortium F~ Protix::cls Reviewed Lab constructed, equIpped at Fudan; t:edlnldans trained !!\!gao acaulng cases Arst Annual Meeting Open\rlg Ceremony In Shanghai Setond Annual Meeting Report Shanghai Health Study Redacted Shanghai Health Study SUmmary .. '~to obtain a better underst3n<1ng, eI the medlanlsm 01 beNene Induced dlsease In hUllliWlS. or\I Signlflalnllmpi'tt on tJenZ...... ~!l< U"'<IUJ!'!'!h HIg!lesI DlJalllll Stinlc!!' empIo\' sQte...,Hhei\I't bIcIogk:aI and ~I scler<:e rep-esenl SOlI1d ~ steward>tdp ~ ~11y I>c5t ptlI(tI:es In research e\IlIcs deI>eM 'UI:>OO partnership 01 tndusUy. 9O"emmenlS. 1<:3dem1. and publIC 3 . The Shanghai Health Study Patsy Clegg ChoIr, o..er>I9hl ~.. _~LP May 2004 What is the ShanghaiHealth Study? G A Iong-tem\ clinical study to investigate the potential causes and development of Iympho-hematopoletlc diseases (diseases of the lymphoid organs, blood and bone millTOW) as related to benzene o A project of Fudan University Medical Center; . UniversitY of Colorado Health Sciences Center; non;Applied Heahtl ScIences an in!lependent U.S. research Chinese pUblic health agencies; and Shanghai hospitals e~l~~!~~~~~ Benefits to Industry :;) Set science-based standards to protect workers and general population from benzene-induced disease ~ Mobile source air toxlcs standards 1/ Water quality standards ~l Site remediation clean.up standards o Corporate responsibility and product stewardship Shanghai Health Study Purpose eTo gain a quantifiable understanding of the relationship between benzene exposure and potential assodated cancer riSks Path to developing the study: "_97: " 97: o 9&<)0: .. 01: " 01: 110m..... eqlO5I.Ire lIS'Odated ...1Il AMl -A-ML-_" _ _ _ ..NO pIAlIlshed a>ndvsIon5 fnlrn OliN! slUdy !hat: - It:t'nnt raw J;:Ma Htf,. ~_- 110 ~ CJIIId>ed fuSlblllty sludleS 11\ ~ AllSIraIlan 10$l!1IJte of _ .. (AlP) ................tieiI/tb WlIId> Study - 100_ --~-- - ... ~_NHL ........ ..,...,.. ..fbIIJr"''''''-Iletuene 1iU!III-.:n ConsortlUm!tnne<l tn: - Ml'WCfq~fI"'JI"OIiJ~"I'lId~ Benzene exposure and cancer Conclusions from pre-1997 Epidemiology r:J Only acute myelogenous leukemia (AML) associated with benzene ~ No risk at exposures < 1 ppm " Oear risk: at exp05!Jres ;. 20 ppm !l Insufficient data at 1-20 ppm tIl assess risk HAZ-SHA-000279 The Shanghai Health Study 1. WCpn!rol~ Traditional, prospecIMo ~ 5II.<!y 1 0 _ risk d AMI, NHLal!lQfl9i>euone ~ ~ 450 AMI. ~ 4SO ~Hl pa!Ietlts Ir1ID swd)I Uniqueness ofShanghai Study o pmspect;ye research " Patients at participating hospitals SQSpetted of . ha'/lng a lymphoid, blood or bone martow disease wiD be referred to the SHS ~ Patients' diets, env/rOllmelltal exposllres and Iilmlty histories wiD be reamled It Patient disease progression followed at supporting hospitals Uniqueness ofShanghai Study c Study will be able to examine primary diagnostic and medical data in real time q) First-hand exposure reports are more reliable than second-hand or reconstructed Information Q) State-owned databaSes document worker hl>tories Uniqueness ofShanghai Study c. Robust data set II StlIte-l'I\iIIntllined benzene exposure and health effeds databases documented from 19705 ~ \lenzene related health effec:t:s are #2 In reported chronic occupational hellltl1 hazards in Olina In1.001 ($wrQr:-,ci_HelIIR) ~ Large range of exposure levels from II variety 1)( oo::upational sources o Regulatory authorities Interest in improving benzene exposure regulation and enforcement Quality, Independent Science II All pro\OCOIs revIeWed and approved by external Ire;titut:ionaI Review Boards (IRS's) GcMom \Jse 01 human subjeds u.s. """ 011"" IndopondEntIy " Shanghai Healtl1 Study independent review panels Intemallonill allIeS IieYIow Pand Intemo!fonal SdmtlIIc _ PaIleI 12 membets . Ii SCIeI>1IftC; disciplines In"""'" durInu entire I""Ject iRedacted HAZ-SHA-000280 2 Benzene Health Research Consortium Organization ~OVersigh.\t ICommlttett..... ~ Techficai/Bud9et Commutcation Recruitment legal SclentII\C ReVoeoi Panel .Ethlcs RevIeW Panel APCO Shanghai Health Study studY partidDan~ PrindpollnoreotiplDrs: .... _ .. '"'"" u.. CokncIo ...... """"" ce.~ Dr. CIllO wong, ~ I1eIaJIh Sdeftca Df.FU~,Fu\S.lnun~ CGIIoboq....., _ _............ aw..PolIidpontsr ...... ""-S<IIoOI .._ .. ..n. .g,.N_I-__. . ..,.'. .""_50_..2.6..._......._I\QIIcO.Io~ID""a.-_1loO --~ , .[ J 1 .~ I Shanghai Health Study I Study lime Uoe e. Shanghai Health Study' Aug 01 3/4Q01 2002 3Q03 Aug 03 4Q03 Aug [)4 2007/8 Consortium Fonned . Protocols Reviewed llIb constnJc:ted, equipped at Fudan; technldans trained Began accruing cases First Annual Meeting Opening Ceremony In Shang hal Second Annual Meeting Report Redacted Shanghai Health Study Summary a Q.omI!lImIl)! to obli>ln a bette< undemllrdlng 01 the mec.IlanIsITI of boruI!ne indUced disease In humans. a Signlftalnt Imi<1 on """ene rtst ~ .~~: employ sGlte-<II-the-art biological and ~I 5den<e u ~ 5OO.I1d product stewanlship ~ty be5t practx:es In research eIhk:s .,.",.,..., upon partnerVo'p of irodustry, governments, iK3defn1. and pUJlk: HAZ-SHA-000281 3 _-i _ _ The Shanghai Health Study Patsy Oegg ChBk", ~ CDmmlt1ee Sho!J 0enICi>15, LP .May 2004 What is the Shanghai Health Study? e A long-term dlnlcal study to investigate the potential causes and development of Iympho-hernatopoletic diseases (diseil5e5 of the lymphoid organs, blood and bone marrow) as related to benzene o A project of Fudan University Medical Center; university of COlorado Health Sciences Center; Applied Health ScienteS - an independent U.S, research firm; Chinese publIC health agehcies; and Shanghai hospitals Benefits to Industry ~ Set science-based standards to protect workers and general population from benzene-Induced disease . ): Mobile source air toxies standards " Water quality standards ~l Site remediation dean-up standards ~ Corporate responsibility and product stewardship Shanghai Health Study Purpose eTo gain a quantifiable understanding of the relationship between benzene exposure and potential associated. cancer risks ;.; Path to developing the study: o Pn>-97: " 97: 98oW: 01: o 01: - -Benz""" e><poSUre assodated With AML NO JIl.tilsMd conclusIonS '""" OlIna stJdy that: - Be:nl'llneUlnCMaNI1L - AMl~.'ea:pas&u"tS~lI'in~Wlwn-r,a HO Metl'oodology oIIIdzed FeaSibility studIeS In SIlangllal AustJallan lnstltul 01 Petroleum's (AlP) Health W.td1 Study .. ~"IDIJI~lnOudIf'IIdITonIC.tvm~ -~- ""'~ttonwt:hNHlO"mu,,*,*~ I\enzene Health Researm ConsortIUm formed \Il' - do.audy ..... _ - IIfI5M:f quc:stionlrJ d5tIaSt pl'"ClgressiDn and ~ Benzene exposure anq cancer Conclusions froni pre-1997 Epidemiology o Only acute myelogenous leukemia (AML) associated with benzene ~ No rlsk at exposures < 1 ppm ~ Oear risk at exposures> 20 ppm ~ Insuffident data <It 1-20 ppm to assess risk HAZ-SHA-000279 The Shanghai Health Study 1. 0.... Cpotm/ sliA' Tradltla1al, prospet1M! epidomIoIogy swc!y to del2lmlne risk of AJoIl, NHl omong benzene ~ wori<ers - 450 AJoIl and 450 NHl pl>llents ~IO study Uniqueness ofShanghai Study o Prospective research Patients at participating hospitalS suspeOed of " having a lymphoid, blood or bone marrow disease wlU be referred to the SHS = Patients' diets, environmental exposures and family histories will berecorded ~ Patient disease progression followed at supporting hospitals Uniqueness ofShanghai Study o Study will be able to examine primary diagnostic and medical data in real time o first-hand exposure reports are more reliable than second-hand or reconstructed Infonnation e State-owned databases document worker histories Uniqueness ofShanghai Study G Robust data set ~ State-maintained benzene exposure and health effects databases docUmented from 19705 ~ Benzene related health effects are "In In reported chronic occupational health hazards in China In 2001 (SDu=-"dPulkHcoaIth) " Large range of exposure levels from a variety of occupational sources <> Regulatory authorities interest in improving benzene exposure regulation and enforcement ,i Quality, Independent Science .. All protocols revIeWed and approved by external Institutional Rev~w Boanls (IRS's) GaIIem .'" 01 human wbjeds m U.s. ;r,d OIIna Independentjy I) Shanghai Health Study independent review panels Intomallonal EIIlIes R.vtew PollOi Internatlonal Sdendflc RevIew Panel lZ members 6 odentlflc disciplines Involved dU11rQ enllle p-oject jRedacted HAZ-SHA-000280 2 Benzene Health Research Consortium Organization /'" 1 1 ____OVersight Commltt~ Tjlcai/Bud9et Commutation Recruitment Legal SdentIIIC _ Panel EthICS RevIew PanEl APCO Shanghai Health Study Study Partfcipants P!lncipol.,,~ D<. _"' ...... u oI~""" _ e o n... Df. 0It0 wong, ApplIed ~ ~ Colo............ _ _ _01'. Fut1U1,fvG.lnUn~ OI_Port/dponts: _-'5aooDIoI_ "_eon. . ,."~""Shongl1ol_. Shlft9MI 00... _ .... -.5<1...........5Iooo1QI\Ij~- Sho....1PltIloI:r_ to< Publl< Shollghll PubIc HtoiIII\e..... u" \10_.Intenol RftIew IIOOnIs COI>oOo....... AIlS Shanghai Health Study Study Time Une Aug 01 3/4Q01 2002 3Q03 Aug 03 <iQ03 Aug 04 2007/8 Consortium Formed . l'I'otocols Reviewed Lab constructed, eqUipped at Fudan; tedlRidans trained Began accruing cases Rrst Annual Meeting Opening Ceremony In Shanghai Second. Annual Meeting Report Shanghai Health Study" Redacted Shanghai Health Study Summary .. ~ Ix> obtain better undentilncllr.g 01 the med1anlsm 01 beNI!ne Induca:l disease In huma05. .. Significant Imp;><1 DO benzene ns!< ~ .~: ~ stallHJl-lhe-art biological .00 epidemiological 5deIlIE repre;en\ $OU1d produ:t stewardship ~Ify best ~es In oesoord1 ethlcs cIep<nIl4)OI1 par1net>hlp 01 Industry, 11"""",",",,15, ac;odemla .00 P\bIIt HAZ-SHA-000281 3 . The Shanghai Health Study Patsy Cle<]g 0.... ~ Canmla: SI'IOIl~ll' May 2004 What is the Shanghai Health Study? II AIong-tenn dinical study to investigate the potential ClIIl5eS and development of lympOO-hematopole1ic diseases (d"wease5 of the lymphoid organs, blQod and bone marrow) as rel~ to beraene o A, projea of FuOiIIl University MedICilI Center; . UnlversltV of Colorado I-IeaIth ScIences Center; Applied Health Stiences - an mdepeOOent U.S, research firm; O1inese public health agenCies; and Shanghai hospll:als Benefits to Industry ~ set sciencebased standards to protect workers and general population from benzene-induced disease ~ Mobile source air taxies standards a Water quality standards I'l Site remediation clean-up standards 10 Corporate responsibility and product stewardship Shanghai Health Study Purpose eTo gain a quantifiable understanding of the relationship between benzene exposure and potential associated cancer risks Path to developing the study: "Pre-97: " 97: " !l6-OO: .. 01: .. 01: - -~ene ~ assodaled woth AMl NO ~~ fnlm Oil'lll SUJdy IIlat: -~t.bttQURNHl AHl~.t~~tINtI-~~ .. m FNoOastM>ieIlItIyIo_:loIo!1f CJ1Ild7ed In Shanghill ~n InstlWte 01 Pe!roIeum's (AlP) H...I\)l~SNcIy ....-_-It" -~-""' ............... wIlI""L.. _..,..,.... -_._<l_""",_MCl_-dO._"'....Benzene11eat111 Reseilrcn ConSQl1lum lCmted 11): ~ Benzene eKQOsure ~nd cancer Conclusions from pre-J997 Epidemiology o Only acute myelogenous leukemia (AML) a~iated with benzene . " No risk at exposures < 1 ppm :: Oear risk at exposures > 20 ppm :I tosulfident datil at 1-20 ppm to assess risk HAZ-SHA-000279 1 The Shanghai Health Study case1. (min!! 5~ TIiIdItIcna~ ~"pIdemIoIogy stue!y II> determine "51< of AML, NHL arncno benzene exposed wori<ers : 450 AHL and 450 NHL pabI!nIS Inlo stLdy 2. DkrW /'rog!!:Wro Stud\! Pn>speclNe m.dy 011 reialion5l11p ril1DlH3NZr booe manow disease ancl benzonelndua!d AHL -... . .. ..... c". . , .. ..~:~t".l:'~;. . .,-,'I.'!.-,I.\l1r!r> ;.."...'""''cl-'";.'it'.;:';~-~.,'V.,,.~.. . .";A. :\ toio, , ., ~. 0:'. ',... ' . . . '....... !. ': ., Uniqueness ofShanghai Study 0'o prospective research Patients at participating hospitals suspec;ted having iI lymphOid, blood or bone marrow disease wlU be referred to the SHS c Patients' diets, environmental exposures and !amity histories wlU be recorded ~ Patient disease progression followed at supporting hospitals _ ....~fJJ~m~~~W': _ ~f.~'v.'~~h~~~f4~:]i Uniqueness ofShanghai Study c Study will be able to examine primary diagnostic and medical data in real time o First-hand exposure reports are more reliable than second-hand or reconstructed Infonnation D State-owned databases document worker histories Uniqueness ofShanghai Study o Robust data set z State-maintained benzene exposure and health effects databases documented from 1970s " Benzene related health effects are 112 In reported chroniC occupational health hazards in Olina in 200 1 (Sou= MJntstry d Putk Heollh) " Larg e range of exposure levelS from a variety of occupational SOUrtes . o Regulatory authorities interest in improving benzene exposure regulation and enforcement Quality, Independent Science Q All protocols revIeWed and approved by external Inst1tutional ReVieW Boards (IRS's) _ use of human SlJbjocIs " U.s. a'ld Ollna Inde\lUldently " Shangnal Health Study independent review panels Intemiltlonal Etnlcs R _ Ponel 1_1lona1 StlenUIic RevIeW Pone! 12 members 6 soentlllc dlsdplines e InwM<i during ,,"lin! project jRedacted HAZ-SHA-000280 2 Benzene Health Research Consortium Organization / 1OVersight Comml~ 1 _____ TjlcallBud9et Commutcation Recnlltment Legal SCIentific RevIew Panel APeO EthICS _ Panel APJ Administrative Support Shanghai Health Study Study partldpants Prindpol~ DDoo..__Wn.l...-. _'U"~.."..".."..S..c..."..""Cen'" OoIIobora.,., or, Fu H&a,. F\IdI,. UntcsKy _ __ _S<ftllalrI_au-Portidponts: ......... 5'_..,_ "_",,,,I<:< _ _S16IIi._....._..nQ_NI'-~ 5ShIoOIOoh_Ol'"'*h_~_I.<..:...<. "''''''_s.~ Shanghai Health Study Study Time Une Aug 01 3/4QOl 2002 3Q03 Aug 03 4Q03 Aug 04 2007/8 Consortium Formed Protocols Reviewed Lab constructed, eqUipped at Fudanj tedlnldans trained B4)gan ilCOlllng cases Arst Annual Meeting Opentng Ceremony In Shanghai second Annual Meeting Report Shanghai Health Study Redacted Shanghai Health Study ,j .~ Summary o ~ 10 ctllaIn beIIer unders1ardlng ~ the medlanlsm of benzene Induced ell_51: 10 humans. a Signl/lcant Impact on benzene risk ;'5secs[DPOl HIgbes! Duality <t Sd!m:: employ st!\IHlI-Ihe-art bIoIaglcilland epldemldlo!/b' sderu ~t 5Ot.fld product mwardShlp ~ txemIlIlfy best p1Ittices In researd1 eIhI<:s depend upon partner>hlp 01 Industry, govemmenlS, ~Io ond public HAZ-SHA-000281 3 The Shanghai Health Study Patsy Clegg Ololr, ~I Ceo",,""''' Shell Q-emIcaIs, I.P May 2004 What is the Shanghai Health Study? e A long-term dlnical study to investigate the potential causes and deVelopment of lympho-hemiltopoIeIic diseases (OISease5 of tile lymphoid Df9a1lS, blood and bone marrow) as related to benzene o A project or Fudan University Medical Center; UniversitY of CoIorildo Health Sdences Centl!r; Applied Health SCIences - an independent U.S. r\!$!!art:h firm; Chin\!$!! public health agencies; and Shanghai hospitals Benefits to Industry ~ Set science-based standards to protect workers and general population from benzene-Induced disease ~ Mobile source air taxies standards II Water quality standards I': Site remediation dean-up standards 10 Corporate responsibility and product stewardship Shanghai Health Study Purpose eTo gain a quantifiable understanding of the"relatlonshlp between benzene exposure and potential associated cancer risks Path to developing the study: p Pre-97: .. 97: " 98-00: .. 01: " 01: - -Benzene """"""'" associated WIlli AML NO ~ mndU$lQnS from 01108 5IuIty 1Ilat: -- ' 1AJeNH'ente~_" c.a.u.s.e.H.I.1.I.... _ ..... _ _ c .,. NO MeIl'ol<llo!1r' CIIIIdled "----..fea5li;lllllysludleslll5/l;l1gllal ~Ilan InstilU!e 01 PeIroIe!Jm'$ (All') Ileaill> Walch StudY --.,-~ - ... _ _ _ NHl ... """""'..,..... ---"'--'''''-IIeru8!le_ill> -.:IICMsoriIUm ftlrmod!D; -110 ....,"' .... _ Benzene exposure and cancer Conclusions from pre-1997 Epidemiology C Only acute myelogenous leukemia (AML) associated with benzene No risk at exposures <: 1 ppm " Dear risk at eKPOSUres > 20 ppm ~ (nsufficient data at 1-20 ppm to assess risk HAZ-SHA-000279 J_ . The Shanghai Health Study I. a... em"", SIu!W Tradlllonill, prv:;pectIve epidemiology study to detennlne rlsk d AML, HHl.mcng ~ ~-'<... 450 AMl and 450 NHl pIIIlenlS Into stLdy 2. DI<ease """""""'" study ~bone marnSrwIl.d_y M relationship d and beN... .IIIOnIcHIu3la1CdeAI"MI. Uniqueness ofShanghai Study c prospective research " Patients at participating hospitals suspected of . having a lymphoid, blood or bone marrow dISease wi. be referred to the SHS = Pallents' diets, environmental exposures and family histories will be recorded " Patient disease progression fonowed at supporting hospitals Uniqueness ofShanghai Study c Study will be able to examine primary diagnOstic and medical data in real time o First-hand exposure reports are more reliable than second-hand or reconstructed Infonnation . OJ State-owned databases document worker histories Uniqueness ofShanghai Study o Robust data set z State-maintained benzene exposure and health effects databases documented from 19705 ~ BellZene related health effects are 112 In reported chronic occupational health hazards in China In 2001 (SD<Jtrz:~dPutic_lh) ~ liIrge range of exposure levels from a vartety of occupational SOUrtes ' o Regulatory authorities interest in Improving benzene exposure regulation and enforcement Quality, Independent Science o All protocols revlewed and approved by external InstitUtional Review Boards (IRS's) G<M!rn use at human subjeds us. rod Olinalrodepenclallly D Shanghai Health Study independent review panels Intl:mallonal EItlIcs Ii....... Pond Inrematlanal Sdentiflc RevIew Pond 12 memberl 6 5Qen1lt\c dlsdpllnes " Involved cIurIng ..,tIn! projeCt jRedacted HAZ-SHA-000280 2 Benzene Health Research Consortium Organization OVersight Commltt~ / , 1 _____ . I"11ca1/Bud9et Communication Recruitment Legal Sdenllllc ,'\""""" Panel Ethics RevIew Panel APeO Shanghai Health Study "'nd" Study PartidDants Jn~ c.. _ ........ u" ' _ ....'" ScJonas eon... 1131""""eo...........: 0Dr... .ru ,Hu., F.vd.,iIn ,u,~- - - - __ _ScIIoot._Dlr-Portidl*ll5! ......, ... " " a . . . _s.._l i ......._ ' - . ..._ ..~c.n... S..N.r_IoIYI P~o",,*,5W0d_etr.... "'''''' _ 5IIonghoJ _ _ Buoeou . Shanghai Health Study Study lime Une Aug 01 3/4QOl 2002 3Q03 Aug 03 4Q03 Aug 0'1 2007/8 Consortium Fonned Protocols Reviewed lab constructed, equipped at Fudanj tedlnJdans trained Began acOlJlng cases FIrst Annual Meeting Opening Ceremooy In Shanghai Second Annual Meeting Report Shanghai Health Study ~ Redacted Shanghai Health Study Summary .. ~ to obtain belter undestandlng 01 the mechanism of benzene Indlla!d disease In humans. .. Sigl>fbnll/npod on bwuene d!k MSf'imJ'lll. .~~: employ stI_ _art bIoIagklll arid epidemiological Sdence " repeent 50ISld prWur;t stEwllrdshlp " e><eI11lIlfy best IQctkeS In rese;.rtil ethic; depen,1upon parmer.nlp 0( Industry, gQ\'emments, acaIemla _I'd publIC HAZ-SHA-000281 3